BLASTX nr result
ID: Zingiber24_contig00043246
seq
BLASTX 2.2.25 [Feb-01-2011]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Zingiber24_contig00043246
(301 letters)
Database: ./nr
37,332,560 sequences; 13,225,080,153 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
ref|XP_006476216.1| PREDICTED: pleiotropic drug resistance prote... 175 5e-42
ref|XP_006476215.1| PREDICTED: pleiotropic drug resistance prote... 175 5e-42
ref|XP_006476214.1| PREDICTED: pleiotropic drug resistance prote... 175 5e-42
ref|XP_006476213.1| PREDICTED: pleiotropic drug resistance prote... 175 5e-42
ref|XP_006450535.1| hypothetical protein CICLE_v10010431mg [Citr... 175 5e-42
gb|EOY26604.1| Pleiotropic drug resistance 12 [Theobroma cacao] 174 1e-41
gb|EXC25846.1| ABC transporter G family member 40 [Morus notabilis] 174 1e-41
gb|EXB80183.1| Pleiotropic drug resistance protein 1 [Morus nota... 174 1e-41
ref|XP_002297806.2| hypothetical protein POPTR_0001s14620g [Popu... 174 1e-41
ref|XP_006465411.1| PREDICTED: pleiotropic drug resistance prote... 173 2e-41
ref|XP_002512728.1| ATP-binding cassette transporter, putative [... 173 2e-41
ref|XP_002303856.2| hypothetical protein POPTR_0003s18140g [Popu... 173 2e-41
ref|XP_002297805.2| hypothetical protein POPTR_0001s14630g [Popu... 172 4e-41
gb|EMJ28283.1| hypothetical protein PRUPE_ppa000234mg [Prunus pe... 172 4e-41
ref|XP_003632800.1| PREDICTED: pleiotropic drug resistance prote... 172 4e-41
ref|XP_003632798.1| PREDICTED: pleiotropic drug resistance prote... 172 4e-41
ref|XP_002285020.2| PREDICTED: pleiotropic drug resistance prote... 172 4e-41
emb|CBI36221.3| unnamed protein product [Vitis vinifera] 172 4e-41
emb|CBI36212.3| unnamed protein product [Vitis vinifera] 172 4e-41
emb|CBI36210.3| unnamed protein product [Vitis vinifera] 172 4e-41
>ref|XP_006476216.1| PREDICTED: pleiotropic drug resistance protein 1-like isoform X4
[Citrus sinensis]
Length = 1446
Score = 175 bits (444), Expect = 5e-42
Identities = 90/100 (90%), Positives = 95/100 (95%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
LVYSAWLRLP EV S+ KMF+EEVMELVEL+P+REALVGLPGVSGLSTEQRKRLTIAVE
Sbjct: 955 LVYSAWLRLPPEVDSDTRKMFVEEVMELVELNPIREALVGLPGVSGLSTEQRKRLTIAVE 1014
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 1015 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1054
>ref|XP_006476215.1| PREDICTED: pleiotropic drug resistance protein 1-like isoform X3
[Citrus sinensis]
Length = 1450
Score = 175 bits (444), Expect = 5e-42
Identities = 90/100 (90%), Positives = 95/100 (95%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
LVYSAWLRLP EV S+ KMF+EEVMELVEL+P+REALVGLPGVSGLSTEQRKRLTIAVE
Sbjct: 959 LVYSAWLRLPPEVDSDTRKMFVEEVMELVELNPIREALVGLPGVSGLSTEQRKRLTIAVE 1018
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 1019 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1058
>ref|XP_006476214.1| PREDICTED: pleiotropic drug resistance protein 1-like isoform X2
[Citrus sinensis]
Length = 1452
Score = 175 bits (444), Expect = 5e-42
Identities = 90/100 (90%), Positives = 95/100 (95%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
LVYSAWLRLP EV S+ KMF+EEVMELVEL+P+REALVGLPGVSGLSTEQRKRLTIAVE
Sbjct: 961 LVYSAWLRLPPEVDSDTRKMFVEEVMELVELNPIREALVGLPGVSGLSTEQRKRLTIAVE 1020
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 1021 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1060
>ref|XP_006476213.1| PREDICTED: pleiotropic drug resistance protein 1-like isoform X1
[Citrus sinensis]
Length = 1463
Score = 175 bits (444), Expect = 5e-42
Identities = 90/100 (90%), Positives = 95/100 (95%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
LVYSAWLRLP EV S+ KMF+EEVMELVEL+P+REALVGLPGVSGLSTEQRKRLTIAVE
Sbjct: 972 LVYSAWLRLPPEVDSDTRKMFVEEVMELVELNPIREALVGLPGVSGLSTEQRKRLTIAVE 1031
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 1032 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1071
>ref|XP_006450535.1| hypothetical protein CICLE_v10010431mg [Citrus clementina]
gi|557553761|gb|ESR63775.1| hypothetical protein
CICLE_v10010431mg [Citrus clementina]
Length = 1452
Score = 175 bits (444), Expect = 5e-42
Identities = 90/100 (90%), Positives = 95/100 (95%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
LVYSAWLRLP EV S+ KMF+EEVMELVEL+P+REALVGLPGVSGLSTEQRKRLTIAVE
Sbjct: 961 LVYSAWLRLPPEVDSDTRKMFVEEVMELVELNPIREALVGLPGVSGLSTEQRKRLTIAVE 1020
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 1021 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1060
>gb|EOY26604.1| Pleiotropic drug resistance 12 [Theobroma cacao]
Length = 1463
Score = 174 bits (441), Expect = 1e-41
Identities = 89/100 (89%), Positives = 95/100 (95%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
L+YSAWLRLP EV +E KMFIEEVMELVEL+PLR+ALVGLPGV+GLSTEQRKRLTIAVE
Sbjct: 969 LLYSAWLRLPAEVNAETRKMFIEEVMELVELNPLRQALVGLPGVNGLSTEQRKRLTIAVE 1028
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 1029 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1068
>gb|EXC25846.1| ABC transporter G family member 40 [Morus notabilis]
Length = 555
Score = 174 bits (440), Expect = 1e-41
Identities = 90/100 (90%), Positives = 94/100 (94%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
L+YSAWLRLP EV SE KMFIEEVMELVEL PLR+ALVGLPGV+GLSTEQRKRLTIAVE
Sbjct: 63 LLYSAWLRLPAEVDSETRKMFIEEVMELVELAPLRQALVGLPGVNGLSTEQRKRLTIAVE 122
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 123 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 162
>gb|EXB80183.1| Pleiotropic drug resistance protein 1 [Morus notabilis]
Length = 1423
Score = 174 bits (440), Expect = 1e-41
Identities = 90/100 (90%), Positives = 94/100 (94%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
L+YSAWLRLP EV SE KMFIEEVMELVEL PLR+ALVGLPGV+GLSTEQRKRLTIAVE
Sbjct: 931 LLYSAWLRLPAEVDSETRKMFIEEVMELVELAPLRQALVGLPGVNGLSTEQRKRLTIAVE 990
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 991 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1030
>ref|XP_002297806.2| hypothetical protein POPTR_0001s14620g [Populus trichocarpa]
gi|550347257|gb|EEE82611.2| hypothetical protein
POPTR_0001s14620g [Populus trichocarpa]
Length = 1215
Score = 174 bits (440), Expect = 1e-41
Identities = 89/100 (89%), Positives = 95/100 (95%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
L+YSAWLRLP+EV SE KMFIEEVM+LVEL+PLR ALVGLPGV+GLSTEQRKRLTIAVE
Sbjct: 933 LLYSAWLRLPLEVDSESRKMFIEEVMDLVELNPLRHALVGLPGVNGLSTEQRKRLTIAVE 992
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 993 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1032
>ref|XP_006465411.1| PREDICTED: pleiotropic drug resistance protein 1-like [Citrus
sinensis]
Length = 1445
Score = 173 bits (439), Expect = 2e-41
Identities = 90/100 (90%), Positives = 94/100 (94%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
L+YSAWLRLP+EV S KMFIEEVMELVEL PLR+ALVGLPGVSGLSTEQRKRLTIAVE
Sbjct: 954 LLYSAWLRLPLEVDSPTQKMFIEEVMELVELKPLRQALVGLPGVSGLSTEQRKRLTIAVE 1013
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 1014 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1053
>ref|XP_002512728.1| ATP-binding cassette transporter, putative [Ricinus communis]
gi|223547739|gb|EEF49231.1| ATP-binding cassette
transporter, putative [Ricinus communis]
Length = 1429
Score = 173 bits (439), Expect = 2e-41
Identities = 90/100 (90%), Positives = 94/100 (94%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
L+YS+WLRLP EV SE KMFIEEVMELVEL PLR+ALVGLPGVSGLSTEQRKRLTIAVE
Sbjct: 938 LLYSSWLRLPPEVNSETRKMFIEEVMELVELTPLRQALVGLPGVSGLSTEQRKRLTIAVE 997
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 998 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1037
>ref|XP_002303856.2| hypothetical protein POPTR_0003s18140g [Populus trichocarpa]
gi|550343433|gb|EEE78835.2| hypothetical protein
POPTR_0003s18140g [Populus trichocarpa]
Length = 1400
Score = 173 bits (438), Expect = 2e-41
Identities = 89/100 (89%), Positives = 94/100 (94%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
L+YS WLRLP EV +E KMFIEEVMELVEL+PLR+ALVGLPGVSGLSTEQRKRLTIAVE
Sbjct: 937 LLYSGWLRLPPEVNAETRKMFIEEVMELVELNPLRQALVGLPGVSGLSTEQRKRLTIAVE 996
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 997 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1036
>ref|XP_002297805.2| hypothetical protein POPTR_0001s14630g [Populus trichocarpa]
gi|550347258|gb|EEE82610.2| hypothetical protein
POPTR_0001s14630g [Populus trichocarpa]
Length = 1407
Score = 172 bits (436), Expect = 4e-41
Identities = 89/100 (89%), Positives = 94/100 (94%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
L+YSAWLRLP EV SE KMFIEEVM+LVEL+PLR ALVGLPGV+GLSTEQRKRLTIAVE
Sbjct: 916 LLYSAWLRLPSEVDSETRKMFIEEVMDLVELNPLRSALVGLPGVNGLSTEQRKRLTIAVE 975
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 976 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1015
>gb|EMJ28283.1| hypothetical protein PRUPE_ppa000234mg [Prunus persica]
Length = 1421
Score = 172 bits (436), Expect = 4e-41
Identities = 89/100 (89%), Positives = 93/100 (93%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
LVYSAWLRLP EV S KMF+EEVMELVEL P+REALVGLPGV+GLSTEQRKRLTIAVE
Sbjct: 926 LVYSAWLRLPPEVDSSTRKMFVEEVMELVELTPIREALVGLPGVNGLSTEQRKRLTIAVE 985
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 986 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1025
>ref|XP_003632800.1| PREDICTED: pleiotropic drug resistance protein 1-like [Vitis
vinifera]
Length = 1769
Score = 172 bits (436), Expect = 4e-41
Identities = 89/100 (89%), Positives = 94/100 (94%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
L+YSAWLRLP +V SE KMFIEEVMELVEL PLR+ALVGLPGV+GLSTEQRKRLTIAVE
Sbjct: 1277 LLYSAWLRLPSDVNSETRKMFIEEVMELVELTPLRDALVGLPGVNGLSTEQRKRLTIAVE 1336
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 1337 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1376
Score = 130 bits (326), Expect = 2e-28
Identities = 67/84 (79%), Positives = 74/84 (88%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
L+YS WLRL +V ++ MFIEEVMELVEL PLR+ALVGLPGV+ LSTEQRKRLTIAVE
Sbjct: 382 LLYSGWLRLSPDVDAKTKMMFIEEVMELVELTPLRDALVGLPGVNSLSTEQRKRLTIAVE 441
Query: 181 LVANPCILFMDEPTSGLDARAAAI 252
LVANP I+FMDEPTSGLDARAAAI
Sbjct: 442 LVANPSIIFMDEPTSGLDARAAAI 465
>ref|XP_003632798.1| PREDICTED: pleiotropic drug resistance protein 1-like [Vitis
vinifera]
Length = 1437
Score = 172 bits (436), Expect = 4e-41
Identities = 89/100 (89%), Positives = 94/100 (94%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
L+YSAWLRLP +V SE KMFIEEVMELVEL PLR+ALVGLPGV+GLSTEQRKRLTIAVE
Sbjct: 945 LLYSAWLRLPSDVNSETRKMFIEEVMELVELTPLRDALVGLPGVNGLSTEQRKRLTIAVE 1004
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 1005 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1044
>ref|XP_002285020.2| PREDICTED: pleiotropic drug resistance protein 1-like [Vitis
vinifera]
Length = 1429
Score = 172 bits (436), Expect = 4e-41
Identities = 89/100 (89%), Positives = 94/100 (94%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
L+YSAWLRLP +V SE KMFIEEVMELVEL PLR+ALVGLPGV+GLSTEQRKRLTIAVE
Sbjct: 937 LLYSAWLRLPSDVNSETRKMFIEEVMELVELTPLRDALVGLPGVNGLSTEQRKRLTIAVE 996
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 997 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1036
>emb|CBI36221.3| unnamed protein product [Vitis vinifera]
Length = 1362
Score = 172 bits (436), Expect = 4e-41
Identities = 89/100 (89%), Positives = 94/100 (94%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
L+YSAWLRLP +V SE KMFIEEVMELVEL PLR+ALVGLPGV+GLSTEQRKRLTIAVE
Sbjct: 870 LLYSAWLRLPSDVNSETRKMFIEEVMELVELTPLRDALVGLPGVNGLSTEQRKRLTIAVE 929
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 930 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 969
>emb|CBI36212.3| unnamed protein product [Vitis vinifera]
Length = 1770
Score = 172 bits (436), Expect = 4e-41
Identities = 89/100 (89%), Positives = 94/100 (94%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
L+YSAWLRLP +V SE KMFIEEVMELVEL PLR+ALVGLPGV+GLSTEQRKRLTIAVE
Sbjct: 1278 LLYSAWLRLPSDVNSETRKMFIEEVMELVELTPLRDALVGLPGVNGLSTEQRKRLTIAVE 1337
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 1338 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1377
>emb|CBI36210.3| unnamed protein product [Vitis vinifera]
Length = 1642
Score = 172 bits (436), Expect = 4e-41
Identities = 89/100 (89%), Positives = 94/100 (94%)
Frame = +1
Query: 1 LVYSAWLRLPVEVGSEKTKMFIEEVMELVELHPLREALVGLPGVSGLSTEQRKRLTIAVE 180
L+YSAWLRLP +V SE KMFIEEVMELVEL PLR+ALVGLPGV+GLSTEQRKRLTIAVE
Sbjct: 1150 LLYSAWLRLPSDVNSETRKMFIEEVMELVELTPLRDALVGLPGVNGLSTEQRKRLTIAVE 1209
Query: 181 LVANPCILFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 300
LVANP I+FMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV
Sbjct: 1210 LVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVV 1249