BLASTX 2.2.26 [Sep-21-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Rehmannia30_contig00006262
         (2979 letters)

Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects 
           149,584,005 sequences; 54,822,741,787 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

ref|XP_011100133.1| DNA topoisomerase 3-alpha [Sesamum indicum]      1607   0.0  
ref|XP_012857604.1| PREDICTED: DNA topoisomerase 3-alpha [Erythr...  1588   0.0  
ref|XP_006341743.1| PREDICTED: DNA topoisomerase 3-alpha [Solanu...  1478   0.0  
ref|XP_015074855.1| PREDICTED: DNA topoisomerase 3-alpha isoform...  1473   0.0  
ref|XP_016547510.1| PREDICTED: DNA topoisomerase 3-alpha isoform...  1461   0.0  
ref|XP_009622049.1| PREDICTED: DNA topoisomerase 3-alpha isoform...  1459   0.0  
gb|PHT68423.1| DNA topoisomerase 3-alpha [Capsicum annuum]           1458   0.0  
ref|XP_010320982.1| PREDICTED: DNA topoisomerase 3-alpha isoform...  1457   0.0  
ref|XP_009622050.1| PREDICTED: DNA topoisomerase 3-alpha isoform...  1421   0.0  
ref|XP_010649354.1| PREDICTED: DNA topoisomerase 3-alpha isoform...  1417   0.0  
ref|XP_010649353.1| PREDICTED: DNA topoisomerase 3-alpha isoform...  1417   0.0  
gb|OVA03617.1| DNA topoisomerase [Macleaya cordata]                  1409   0.0  
ref|XP_023917748.1| DNA topoisomerase 3-alpha isoform X2 [Quercu...  1406   0.0  
ref|XP_023917747.1| DNA topoisomerase 3-alpha isoform X1 [Quercu...  1397   0.0  
ref|XP_010270299.1| PREDICTED: DNA topoisomerase 3-alpha [Nelumb...  1395   0.0  
gb|EOX92637.1| Topoisomerase 3alpha isoform 1 [Theobroma cacao]      1393   0.0  
ref|XP_024025914.1| DNA topoisomerase 3-alpha [Morus notabilis]      1392   0.0  
ref|XP_007048480.2| PREDICTED: DNA topoisomerase 3-alpha isoform...  1391   0.0  
ref|XP_017969682.1| PREDICTED: DNA topoisomerase 3-alpha isoform...  1390   0.0  
ref|XP_021274352.1| DNA topoisomerase 3-alpha isoform X2 [Herran...  1386   0.0  

>ref|XP_011100133.1| DNA topoisomerase 3-alpha [Sesamum indicum]
          Length = 906

 Score = 1607 bits (4160), Expect = 0.0
 Identities = 776/919 (84%), Positives = 823/919 (89%), Gaps = 4/919 (0%)
 Frame = -2

Query: 2930 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2751
            MAGGGGRPLRALNVAEKPSVAKAVSGIL++ PSSGGLRVR+GRSRYN+IFEFNY IQNQQ
Sbjct: 1    MAGGGGRPLRALNVAEKPSVAKAVSGILARNPSSGGLRVREGRSRYNKIFEFNYAIQNQQ 60

Query: 2750 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2571
             HM+FTSVTGHLME++FEDRYRKWHSCDPVDLYHAPVKK+VP DKS+IEKTLEEEARK Q
Sbjct: 61   FHMAFTSVTGHLMEVEFEDRYRKWHSCDPVDLYHAPVKKHVPHDKSDIEKTLEEEARKSQ 120

Query: 2570 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFS 2391
            WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRAR SALIDREIHY+ QHL+RPNQLF+
Sbjct: 121  WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYAAQHLIRPNQLFA 180

Query: 2390 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFW 2211
            DAVD RQEIDLRIGASFTRFQTMLLRDAFVLDF TD+ NVILSYGPCQF          W
Sbjct: 181  DAVDVRQEIDLRIGASFTRFQTMLLRDAFVLDFTTDDKNVILSYGPCQF----------W 230

Query: 2210 EVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQ 2031
            E+QSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCA I+YEMCVQEPTATVTNVRQQ
Sbjct: 231  EIQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCATILYEMCVQEPTATVTNVRQQ 290

Query: 2030 EKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLH 1851
            EK KYPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQAGFISYPRTETDCFS RTDLH
Sbjct: 291  EKPKYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQAGFISYPRTETDCFSERTDLH 350

Query: 1850 TIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHH 1671
             IVQ+QQ HP+WGSYAQRLLDPE+ LWRNPSGGGHDDKAHPPIHPTKFS+GESGWS DHH
Sbjct: 351  RIVQDQQAHPIWGSYAQRLLDPESGLWRNPSGGGHDDKAHPPIHPTKFSSGESGWSQDHH 410

Query: 1670 KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMI 1491
            KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGS+I
Sbjct: 411  KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSVI 470

Query: 1490 PTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 1311
            PTY YGQQFTPTTLTLD+GVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA
Sbjct: 471  PTYTYGQQFTPTTLTLDSGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 530

Query: 1310 TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQ 1131
            TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRA MESDMKAVSMGTK KAEVLEACLQ
Sbjct: 531  TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAAMESDMKAVSMGTKSKAEVLEACLQ 590

Query: 1130 QMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPD 951
            QMKACF+DARLNKGKLFEAMAVFFERSNRSN NE +AIG+V+R+CGLCQESDMVLR+KPD
Sbjct: 591  QMKACFLDARLNKGKLFEAMAVFFERSNRSNGNEPYAIGDVLRRCGLCQESDMVLRRKPD 650

Query: 950  GNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVN 771
            GNFMVGCLG+PQCRNVVWLPGSVSEA VT+NICSTCSPGPVY+IQFKFRRLEIPPNYNV+
Sbjct: 651  GNFMVGCLGYPQCRNVVWLPGSVSEAAVTSNICSTCSPGPVYMIQFKFRRLEIPPNYNVD 710

Query: 770  HLGCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSS 591
            HLGCIGGCD+ LRQLVE+CGTGSRNNS++                       AW T HSS
Sbjct: 711  HLGCIGGCDNTLRQLVEICGTGSRNNSNM-PGRGQGHTQSSSSAQSNSRSQGAWHTAHSS 769

Query: 590  GSYANAPESSRGRNSRSQEA----GESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQG 423
             SY +  +SSRGR++++Q+A    GESSIPC+SCGAPCNLRTANTPANRGRKFYSCQAQG
Sbjct: 770  SSYTS--QSSRGRSAQTQDAAGEDGESSIPCASCGAPCNLRTANTPANRGRKFYSCQAQG 827

Query: 422  CNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPISGR 243
            CNFF+WEDNA+SGGTVPRGS                           +F+SATGEPISGR
Sbjct: 828  CNFFIWEDNANSGGTVPRGSTSRSASTSSRRGGRGRSNQSRGRANDVAFVSATGEPISGR 887

Query: 242  CFVCGDPGHFANACPNRGR 186
            CFVCGDP HFANACPNRGR
Sbjct: 888  CFVCGDPSHFANACPNRGR 906


>ref|XP_012857604.1| PREDICTED: DNA topoisomerase 3-alpha [Erythranthe guttata]
 gb|EYU20574.1| hypothetical protein MIMGU_mgv1a000984mg [Erythranthe guttata]
          Length = 923

 Score = 1588 bits (4113), Expect = 0.0
 Identities = 772/923 (83%), Positives = 813/923 (88%), Gaps = 8/923 (0%)
 Frame = -2

Query: 2930 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2751
            MAGGGGRPLRALNVAEKPSVAKAVSGILSK PSSGGLRVR+GRSRYN+IFEFNY IQNQQ
Sbjct: 1    MAGGGGRPLRALNVAEKPSVAKAVSGILSKNPSSGGLRVREGRSRYNKIFEFNYAIQNQQ 60

Query: 2750 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2571
              MSFTSVTGHLMEL+FEDRYRKWHSCDPVDLYHAPV+K+VP+DKS+IEKTLEEEARKCQ
Sbjct: 61   FQMSFTSVTGHLMELEFEDRYRKWHSCDPVDLYHAPVRKHVPQDKSDIEKTLEEEARKCQ 120

Query: 2570 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFS 2391
            WLILWLDCDREGENIAFEVVE C R NRNLNIWRAR SALIDREIH +VQHLVRPNQLF+
Sbjct: 121  WLILWLDCDREGENIAFEVVEACLRTNRNLNIWRARFSALIDREIHDAVQHLVRPNQLFA 180

Query: 2390 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFW 2211
            DAVD RQEIDLRIGASFTRFQTMLL+DAFVLDFAT+  NVILSYGPCQFPTLGF+VERFW
Sbjct: 181  DAVDVRQEIDLRIGASFTRFQTMLLKDAFVLDFATEERNVILSYGPCQFPTLGFVVERFW 240

Query: 2210 EVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQ 2031
            E+QSHEPEEFWTINCTHNSEEGTATF+WMRGHLFDYTCA IIYEMCV EP ATVTNVR Q
Sbjct: 241  EIQSHEPEEFWTINCTHNSEEGTATFSWMRGHLFDYTCATIIYEMCVLEPNATVTNVRNQ 300

Query: 2030 EKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLH 1851
            EK +YPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQAGFISYPRTETD FSVRTDLH
Sbjct: 301  EKPRYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQAGFISYPRTETDSFSVRTDLH 360

Query: 1850 TIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHH 1671
            TIVQEQQGHP WGSYAQRLLDPEA LWRNPS GGHDDKAHPPIHPTKFSAGESGWS DHH
Sbjct: 361  TIVQEQQGHPTWGSYAQRLLDPEAGLWRNPSSGGHDDKAHPPIHPTKFSAGESGWSQDHH 420

Query: 1670 KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMI 1491
            KVYELVVRHFLACVSQPAIGA TTV+IDIAGEQFSASG VI+AKNYLDVYRFETWGGSMI
Sbjct: 421  KVYELVVRHFLACVSQPAIGAVTTVDIDIAGEQFSASGTVILAKNYLDVYRFETWGGSMI 480

Query: 1490 PTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 1311
            PTYNYGQQFTPTTLTLD+GVTRPPPLLSEADLLSCMD AGIGTDATMHDHIKKLLDRFYA
Sbjct: 481  PTYNYGQQFTPTTLTLDSGVTRPPPLLSEADLLSCMDNAGIGTDATMHDHIKKLLDRFYA 540

Query: 1310 TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQ 1131
            TKDS+MRFSPTKLGEALV GYDDMGYELWKP LRAMMESDMKAVSMGTKRK+EVL++CLQ
Sbjct: 541  TKDSNMRFSPTKLGEALVKGYDDMGYELWKPNLRAMMESDMKAVSMGTKRKSEVLDSCLQ 600

Query: 1130 QMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPD 951
            QMKACFVDARLNK KLFEAM VFFERSNR+N NEQ AIGEVVRKCGLCQESDMVLRKKPD
Sbjct: 601  QMKACFVDARLNKEKLFEAMDVFFERSNRANGNEQQAIGEVVRKCGLCQESDMVLRKKPD 660

Query: 950  GNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVN 771
            GNFMVGCLG+PQCRNVVWLPGSVSEA VTT ICSTCSPGPVY+IQFKFRRLEIPPNYNV+
Sbjct: 661  GNFMVGCLGYPQCRNVVWLPGSVSEATVTTTICSTCSPGPVYMIQFKFRRLEIPPNYNVD 720

Query: 770  HLGCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHS- 594
            HLGCIGGCDD LRQLVE+CGTGSR  SSV                       AWQT  S 
Sbjct: 721  HLGCIGGCDDTLRQLVEICGTGSRTTSSVPGRGQGHTSSSSSAQQSNYRDQGAWQTASSA 780

Query: 593  --SGSYANAPESSRGRNSRSQEA-----GESSIPCSSCGAPCNLRTANTPANRGRKFYSC 435
              + S ++  +SSRGR++RSQ A     GESSIPC+SCGA CNLRTANT AN+GRKFYSC
Sbjct: 781  WQTASGSHPSQSSRGRSARSQRAGGAPDGESSIPCTSCGASCNLRTANTEANKGRKFYSC 840

Query: 434  QAQGCNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEP 255
            QAQGC+FFVWEDN +SGGT  RG                            +F+SATGEP
Sbjct: 841  QAQGCSFFVWEDNINSGGTAARGGGGRSASTTSRRGGRGRGSRGGGRTNDVAFVSATGEP 900

Query: 254  ISGRCFVCGDPGHFANACPNRGR 186
            ISGRCFVCG+PGHF+N CP RGR
Sbjct: 901  ISGRCFVCGEPGHFSNVCPCRGR 923


>ref|XP_006341743.1| PREDICTED: DNA topoisomerase 3-alpha [Solanum tuberosum]
          Length = 915

 Score = 1478 bits (3827), Expect = 0.0
 Identities = 712/920 (77%), Positives = 787/920 (85%), Gaps = 6/920 (0%)
 Frame = -2

Query: 2930 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2751
            MAGGGGR +R LNVAEKPSVAKAVSGILSK    GG+RVRDGRSRYN+IFEFNYTI+NQ 
Sbjct: 1    MAGGGGRVIRVLNVAEKPSVAKAVSGILSKN-QPGGMRVRDGRSRYNKIFEFNYTIRNQP 59

Query: 2750 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2571
              M FTSVTGHLMEL+F++RYRKWHSCDP+DLY+APV+K+VPEDK +I++TLE EAR CQ
Sbjct: 60   CQMLFTSVTGHLMELEFDERYRKWHSCDPLDLYNAPVRKFVPEDKLDIKRTLEAEARSCQ 119

Query: 2570 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFS 2391
            W++LWLDCDREGENIAFEV++VC +AN NLN+WRAR SALIDREIH SVQ LV+PNQLFS
Sbjct: 120  WIVLWLDCDREGENIAFEVLDVCRQANHNLNVWRARFSALIDREIHQSVQTLVQPNQLFS 179

Query: 2390 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFW 2211
            DAVD RQEIDLRIGASFTRFQTMLLR AFVLDFATD+ N++LSYGPCQFPTLGF+VER+W
Sbjct: 180  DAVDVRQEIDLRIGASFTRFQTMLLRGAFVLDFATDDRNIVLSYGPCQFPTLGFVVERYW 239

Query: 2210 EVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQ 2031
            E+Q+HEPEEFWTINCTHNS+EGTATFNWMRGHLFDYTC + IYEMC+QEP ATVT V+QQ
Sbjct: 240  EIQAHEPEEFWTINCTHNSDEGTATFNWMRGHLFDYTCGVTIYEMCIQEPIATVTKVKQQ 299

Query: 2030 EKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLH 1851
            EKLKYPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQ GFISYPRTETD FS +TDL 
Sbjct: 300  EKLKYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQNGFISYPRTETDSFSEKTDLR 359

Query: 1850 TIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHH 1671
            T+VQEQ+GHPVWG YAQRLLDP++ LWRNPSGGGHDDKAHPPIHPTKFSAGE+ WS DHH
Sbjct: 360  TMVQEQEGHPVWGIYAQRLLDPQSGLWRNPSGGGHDDKAHPPIHPTKFSAGETRWSQDHH 419

Query: 1670 KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMI 1491
            +VYELVVRHFLACVSQPA+GAET VEIDIAGE FSA GRVI+AKNYLDVYRFE+WGGS+I
Sbjct: 420  RVYELVVRHFLACVSQPAVGAETIVEIDIAGESFSACGRVILAKNYLDVYRFESWGGSVI 479

Query: 1490 PTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 1311
            PTY++GQQFTPTTLTLD+GVTRPPPLLSEADLL CMDKAGIGTDATMHDHIKKLLDRFYA
Sbjct: 480  PTYSFGQQFTPTTLTLDSGVTRPPPLLSEADLLGCMDKAGIGTDATMHDHIKKLLDRFYA 539

Query: 1310 TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQ 1131
             KDS+ RFSPTKLGEALVMGYDDMGYELWKPYLRAMME DMKAVS+GTKRKAEVLE CLQ
Sbjct: 540  IKDSNTRFSPTKLGEALVMGYDDMGYELWKPYLRAMMECDMKAVSIGTKRKAEVLETCLQ 599

Query: 1130 QMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPD 951
            QMKACF DAR NKGKL EAMA+FFERSNRS+  EQ A+G+VVR+CGLC ESDMVLR+KPD
Sbjct: 600  QMKACFSDARTNKGKLLEAMAIFFERSNRSSGGEQQAVGDVVRRCGLCLESDMVLRQKPD 659

Query: 950  GNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVN 771
            GNFMVGCLG+PQCRNVVWLPGSVSEA VT N C++CSPGPV+ IQFKFRRLEIPPNY+V 
Sbjct: 660  GNFMVGCLGYPQCRNVVWLPGSVSEASVTENTCTSCSPGPVFKIQFKFRRLEIPPNYSVQ 719

Query: 770  HLGCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAW----QT 603
            HLGCIGGCDDILRQLVE+CGTGSRNNS+                        +     QT
Sbjct: 720  HLGCIGGCDDILRQLVEICGTGSRNNSNTSGRGRGNPTASSSAQRGNSRAQSSCAYCRQT 779

Query: 602  GHSSGSYANAPESSRGRNSRSQEA--GESSIPCSSCGAPCNLRTANTPANRGRKFYSCQA 429
            GH S    +  ++SRGR +R+QE   GESSIPC+SCGAPC LRTANT  NRGRKF+SCQ+
Sbjct: 780  GHLSNDCPS--QASRGRTARAQEVDNGESSIPCNSCGAPCILRTANTANNRGRKFFSCQS 837

Query: 428  QGCNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPIS 249
            Q CNFFVWEDN  +GG   R +                           SF+SATGEPI+
Sbjct: 838  QECNFFVWEDNL-NGGRAERAN-TSASTSSGRGGRGRGRGQSGAHSSNVSFVSATGEPIT 895

Query: 248  GRCFVCGDPGHFANACPNRG 189
            GRCF+CGDPGHFAN CP RG
Sbjct: 896  GRCFICGDPGHFANVCPRRG 915


>ref|XP_015074855.1| PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Solanum pennellii]
          Length = 917

 Score = 1473 bits (3814), Expect = 0.0
 Identities = 708/920 (76%), Positives = 782/920 (85%), Gaps = 6/920 (0%)
 Frame = -2

Query: 2930 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2751
            MAGGGGR +R LNVAEKPSVAKAVSGILSK    GG+RVRDGRSRYN+IFEFNYTI+NQ 
Sbjct: 1    MAGGGGRVIRVLNVAEKPSVAKAVSGILSKN-QPGGIRVRDGRSRYNKIFEFNYTIRNQP 59

Query: 2750 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2571
              M FTSVTGHLME++F +RYRKWHSCDP+DLY+APV+K+VPEDK +I++TLE EAR CQ
Sbjct: 60   CQMLFTSVTGHLMEIEFHERYRKWHSCDPLDLYNAPVRKFVPEDKLDIKRTLEAEARSCQ 119

Query: 2570 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFS 2391
            W+ILWLDCDREGENIAFEV++VC +AN NL +WRAR SALIDREIH SVQ LV+PNQLFS
Sbjct: 120  WIILWLDCDREGENIAFEVLDVCRQANHNLTVWRARFSALIDREIHQSVQTLVQPNQLFS 179

Query: 2390 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFW 2211
            DAVD RQEIDLRIGASFTRFQTMLLR AFVLDFATD+ N++LSYGPCQFPTLGF+VER+W
Sbjct: 180  DAVDVRQEIDLRIGASFTRFQTMLLRGAFVLDFATDDRNLVLSYGPCQFPTLGFVVERYW 239

Query: 2210 EVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQ 2031
            E+Q+HEPEEFWTINCTHNS+EGTATFNWMRGHLFDYTC ++IYEMC+QEP ATVT V+QQ
Sbjct: 240  EIQAHEPEEFWTINCTHNSDEGTATFNWMRGHLFDYTCGVMIYEMCIQEPIATVTKVKQQ 299

Query: 2030 EKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLH 1851
            EKLKYPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQ GFISYPRTETDCFS +TDL 
Sbjct: 300  EKLKYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQNGFISYPRTETDCFSDKTDLR 359

Query: 1850 TIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHH 1671
            T+VQEQ+GHPVWG+YAQRLLDP++ LWRNPSGGGHDDKAHPPIHPTKFSAGE+ WS DHH
Sbjct: 360  TMVQEQEGHPVWGTYAQRLLDPQSGLWRNPSGGGHDDKAHPPIHPTKFSAGETRWSQDHH 419

Query: 1670 KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMI 1491
            +VYELVVRHFLACVSQPA+GAET VEIDIAGE FSA GRVI+AKNYLDVYRFE+WGGS+I
Sbjct: 420  RVYELVVRHFLACVSQPAVGAETIVEIDIAGESFSACGRVILAKNYLDVYRFESWGGSVI 479

Query: 1490 PTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 1311
            PTY++GQQFTPTTLTLD+GVTRPPPLLSEADLL CMDKAGIGTDATMHDHIKKLLDRFYA
Sbjct: 480  PTYSFGQQFTPTTLTLDSGVTRPPPLLSEADLLGCMDKAGIGTDATMHDHIKKLLDRFYA 539

Query: 1310 TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQ 1131
             KDS+ RFSPTKLGEALVMGYDDMGYELWKPYLRAMME DMKAVS GTKRKAEVLE CLQ
Sbjct: 540  IKDSNTRFSPTKLGEALVMGYDDMGYELWKPYLRAMMECDMKAVSTGTKRKAEVLETCLQ 599

Query: 1130 QMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPD 951
            QMKACF DAR NKGKL EAMA+FFERSNRS+S EQ A+G VVR+CGLC ESDMVLR+KPD
Sbjct: 600  QMKACFSDARTNKGKLLEAMAIFFERSNRSSSGEQQAVGAVVRRCGLCLESDMVLRQKPD 659

Query: 950  GNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVN 771
            GNFMVGCLG+PQCRNVVWLPGSVSEA VT N C TCSPGPV+ IQFKFR+ EIPP+Y+V 
Sbjct: 660  GNFMVGCLGYPQCRNVVWLPGSVSEASVTENTCITCSPGPVFKIQFKFRQQEIPPDYSVQ 719

Query: 770  HLGCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAW----QT 603
            HLGCIGGCDDILRQLVE+CGTGSRN+S+                        +     QT
Sbjct: 720  HLGCIGGCDDILRQLVEICGTGSRNSSNTSGRGRGNPTASSSAQRDNSRAQISCAYCRQT 779

Query: 602  GHSSGSYANAPESSRGRNSRSQEA--GESSIPCSSCGAPCNLRTANTPANRGRKFYSCQA 429
            GH S    +  ++SRGR +R+QE   GESSIPC+SCGAPC LRTANT  NRGRKF+SCQ+
Sbjct: 780  GHLSNDCPS--QASRGRTARAQEVDNGESSIPCNSCGAPCILRTANTANNRGRKFFSCQS 837

Query: 428  QGCNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPIS 249
              CNFFVWEDN S G      +                           SF+SATGEPI+
Sbjct: 838  SECNFFVWEDNLSGGRAERANTSASTSSGRGGRGRGRGCGQSGAHSSNVSFVSATGEPIT 897

Query: 248  GRCFVCGDPGHFANACPNRG 189
            GRCF+CGDPGHFAN CP RG
Sbjct: 898  GRCFICGDPGHFANVCPRRG 917


>ref|XP_016547510.1| PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Capsicum annuum]
          Length = 916

 Score = 1461 bits (3783), Expect = 0.0
 Identities = 705/920 (76%), Positives = 777/920 (84%), Gaps = 6/920 (0%)
 Frame = -2

Query: 2930 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2751
            MAGG GR +R LNVAEKPSVAKAVSGILSK    GG+RVRDGRSRYN+IFEFNYTI+NQ 
Sbjct: 1    MAGGRGRTIRVLNVAEKPSVAKAVSGILSKN-QPGGMRVRDGRSRYNKIFEFNYTIRNQP 59

Query: 2750 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2571
              M FTSVTGHLMEL+F+DRYRKWHSCDPVDLY+APV+KYVPEDK +I++TLE EAR CQ
Sbjct: 60   CQMLFTSVTGHLMELEFDDRYRKWHSCDPVDLYNAPVRKYVPEDKLDIKRTLEAEARSCQ 119

Query: 2570 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFS 2391
            W+ILWLDCDREGENIAFEV++VC +AN NLN+WRAR SALIDREIH SVQ LV+PNQLFS
Sbjct: 120  WIILWLDCDREGENIAFEVLDVCRQANNNLNVWRARFSALIDREIHQSVQTLVQPNQLFS 179

Query: 2390 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFW 2211
            DAVD RQEIDLRIGASFTRFQTMLLR+AFVLD A D+ NV+LSYGPCQFPTLGF+VER+W
Sbjct: 180  DAVDVRQEIDLRIGASFTRFQTMLLRNAFVLDVAMDDRNVVLSYGPCQFPTLGFVVERYW 239

Query: 2210 EVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQ 2031
            E+Q+HEPEEFWTINCTHNS+EG ATFNWMRGHLFDY+C +IIYEMC+QEPTATVT V+QQ
Sbjct: 240  EIQAHEPEEFWTINCTHNSDEGIATFNWMRGHLFDYSCGVIIYEMCIQEPTATVTKVKQQ 299

Query: 2030 EKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLH 1851
            EKLKYPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQ GFISYPRTETDCFS +TDL 
Sbjct: 300  EKLKYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQNGFISYPRTETDCFSEKTDLC 359

Query: 1850 TIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHH 1671
            T+VQEQ GHPVWGSYAQRLLDPE  LW+NPSGGGHDDKAHPPIHPTKFSAGES WS DHH
Sbjct: 360  TMVQEQGGHPVWGSYAQRLLDPELGLWKNPSGGGHDDKAHPPIHPTKFSAGESRWSQDHH 419

Query: 1670 KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMI 1491
            +VYELVVRHFLACVSQPA+GAET VEIDIAGE FSA GRVI+AKNYLDVYRFE+WGGS+I
Sbjct: 420  RVYELVVRHFLACVSQPAVGAETIVEIDIAGESFSACGRVILAKNYLDVYRFESWGGSVI 479

Query: 1490 PTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 1311
            PTY++GQQFTPTTLTLD+GVTRPPPLLSEADLL CMDKAGIGTDATMHDHIKKLLDRFYA
Sbjct: 480  PTYSFGQQFTPTTLTLDSGVTRPPPLLSEADLLGCMDKAGIGTDATMHDHIKKLLDRFYA 539

Query: 1310 TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQ 1131
             KDS+ RFSPTKLGEALVMGYDDMGYELWKPYLRAMME DMKAVS+GTKRKAEVLE CLQ
Sbjct: 540  IKDSNTRFSPTKLGEALVMGYDDMGYELWKPYLRAMMECDMKAVSIGTKRKAEVLETCLQ 599

Query: 1130 QMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPD 951
            QMKACF+DAR N+GKLFEAMA+FFE SNRS+  E  A+G VVR+CGLC ESDMVLR+K D
Sbjct: 600  QMKACFLDARTNRGKLFEAMAIFFESSNRSSGGELQAVGGVVRRCGLCLESDMVLRQKSD 659

Query: 950  GNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVN 771
            G+FMVGCLG+PQCRN VWLPGSVSEA VT N C++CSPGPV+ IQFKFRRLEIPPNY+V 
Sbjct: 660  GSFMVGCLGYPQCRNAVWLPGSVSEAFVTENTCTSCSPGPVFKIQFKFRRLEIPPNYSVQ 719

Query: 770  HLGCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSS 591
            HLGCIGGCDDILRQLVE+CGTGSR++S+                        +      +
Sbjct: 720  HLGCIGGCDDILRQLVEICGTGSRSSSNPLGRGRGNPTSSSSAQRGNSRAQSSCAYCRQA 779

Query: 590  GSYAN--APESSRGRNSRSQEA----GESSIPCSSCGAPCNLRTANTPANRGRKFYSCQA 429
            G  +N    + SRGR + SQE     GE SIPC+SCGAPC LRTANT  NRGRKF+SCQ+
Sbjct: 780  GHLSNDCPSQGSRGRTALSQEVDLQNGEPSIPCNSCGAPCILRTANTANNRGRKFFSCQS 839

Query: 428  QGCNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPIS 249
            QGCNFFVWEDN + G    R                             SF++ATGEPI+
Sbjct: 840  QGCNFFVWEDNLTRG----RAERANTSASTSSGRGGRGRGQGGAYPSSVSFVAATGEPIT 895

Query: 248  GRCFVCGDPGHFANACPNRG 189
            GRCF+CGDPGHFAN CP RG
Sbjct: 896  GRCFICGDPGHFANVCPRRG 915


>ref|XP_009622049.1| PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Nicotiana
            tomentosiformis]
 ref|XP_016447097.1| PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Nicotiana tabacum]
          Length = 913

 Score = 1459 bits (3776), Expect = 0.0
 Identities = 699/920 (75%), Positives = 777/920 (84%), Gaps = 8/920 (0%)
 Frame = -2

Query: 2924 GGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVH 2745
            GGGGR +R LNVAEKPSVAKAVSGILS+    GG+RVRDGRSRYN+IFEFNYTI+NQ   
Sbjct: 5    GGGGRVIRVLNVAEKPSVAKAVSGILSRN-QGGGMRVRDGRSRYNKIFEFNYTIRNQPCQ 63

Query: 2744 MSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWL 2565
            M FTSVTGHLMEL+F+DR+RKWHSCDP+ LY APV+KYVP+DK +I++TLEEEA +CQW+
Sbjct: 64   MLFTSVTGHLMELEFDDRFRKWHSCDPLHLYDAPVRKYVPQDKLDIKRTLEEEASRCQWI 123

Query: 2564 ILWLDCDREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFSDA 2385
            ILWLDCDREGENIAFEV+EVC +AN NLN+WRAR SALIDREIH S Q LV+PNQLFSDA
Sbjct: 124  ILWLDCDREGENIAFEVLEVCRQANHNLNVWRARFSALIDREIHQSAQTLVQPNQLFSDA 183

Query: 2384 VDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEV 2205
            VD RQEIDLRIGASFTRFQTMLLRDAFVLDFATD+ N++LSYGPCQFPTLGF+VER+WE+
Sbjct: 184  VDVRQEIDLRIGASFTRFQTMLLRDAFVLDFATDDRNLVLSYGPCQFPTLGFVVERYWEI 243

Query: 2204 QSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEK 2025
            Q+HEPEEFWTINCTHN +EG+ATFNWMRGHLFDYTCA+ IYEMC+QEPTATV+ V+QQEK
Sbjct: 244  QAHEPEEFWTINCTHNFDEGSATFNWMRGHLFDYTCAVTIYEMCIQEPTATVSKVKQQEK 303

Query: 2024 LKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTI 1845
            LKYPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQ GFISYPRTETDCFS +TDL T+
Sbjct: 304  LKYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQNGFISYPRTETDCFSEKTDLRTM 363

Query: 1844 VQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKV 1665
            VQEQ GHPVWGSYAQRLLDP++ LWRNPSGGGHDDKAHPPIHPTKFSAGES WS DHH+V
Sbjct: 364  VQEQGGHPVWGSYAQRLLDPQSGLWRNPSGGGHDDKAHPPIHPTKFSAGESRWSQDHHRV 423

Query: 1664 YELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPT 1485
            YELVVRHFLACVS+PA+GAETTVEIDIAGE F A GRVI+AKNYLDVYRFE+WGGS+IPT
Sbjct: 424  YELVVRHFLACVSKPAVGAETTVEIDIAGESFFACGRVILAKNYLDVYRFESWGGSVIPT 483

Query: 1484 YNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATK 1305
            Y +GQQF PT+LTLD+GVTRPPPLLSEADLL CMDKAGIGTDATMHDHIKKLLDRFYA K
Sbjct: 484  YTFGQQFIPTSLTLDSGVTRPPPLLSEADLLGCMDKAGIGTDATMHDHIKKLLDRFYAIK 543

Query: 1304 DSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQM 1125
            DSS RFSPTKLGEALVMGYDDMGYELWKPYLRAMME DMKAVSMGTKRK EVLE CLQQM
Sbjct: 544  DSSTRFSPTKLGEALVMGYDDMGYELWKPYLRAMMECDMKAVSMGTKRKTEVLETCLQQM 603

Query: 1124 KACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGN 945
            KACF+DAR NKGKLFEAMA+FFERSNRS+  EQ A+G+VVR+CGLC ESDMVLR+KPDGN
Sbjct: 604  KACFLDARANKGKLFEAMAIFFERSNRSSGGEQQAVGDVVRRCGLCLESDMVLRQKPDGN 663

Query: 944  FMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHL 765
            FMVGCLG+PQCRNVVWLPGS+SEA VT N C++C PGPVY IQF+FRRLEIPPNY+  H+
Sbjct: 664  FMVGCLGYPQCRNVVWLPGSLSEASVTENTCTSCGPGPVYKIQFRFRRLEIPPNYSAQHI 723

Query: 764  GCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAW----QTGH 597
            GCIGGCDDILRQLVE+CGTGSR++S+                        +     QTGH
Sbjct: 724  GCIGGCDDILRQLVEICGTGSRSSSNTFGRGRGNPRASSSAQRGNSRAQGSCAYCRQTGH 783

Query: 596  SSGSYANAPESSRGRNSRSQEA----GESSIPCSSCGAPCNLRTANTPANRGRKFYSCQA 429
             S    +  ++SR R +RSQE     GE  IPC+SCG PCNLRTANT  NRGRKF+SCQ+
Sbjct: 784  LSNDCPS--QASRSRTARSQEVDLQNGEPLIPCNSCGEPCNLRTANTANNRGRKFFSCQS 841

Query: 428  QGCNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPIS 249
            + CNFFVWED  + G      +                           SF+SATGEPI+
Sbjct: 842  RECNFFVWEDTLNGGERTNTSA--------STSSRRGGRGQGGPNTSGVSFVSATGEPIT 893

Query: 248  GRCFVCGDPGHFANACPNRG 189
            GRCF+CGDPGHFAN CP RG
Sbjct: 894  GRCFICGDPGHFANVCPRRG 913


>gb|PHT68423.1| DNA topoisomerase 3-alpha [Capsicum annuum]
          Length = 916

 Score = 1458 bits (3775), Expect = 0.0
 Identities = 704/920 (76%), Positives = 776/920 (84%), Gaps = 6/920 (0%)
 Frame = -2

Query: 2930 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2751
            MAGG GR +R LNVAEKPSVAKAVSGILSK    GG+RVRDGRSRYN+IFEFNYTI+NQ 
Sbjct: 1    MAGGRGRTIRVLNVAEKPSVAKAVSGILSKN-QPGGMRVRDGRSRYNKIFEFNYTIRNQP 59

Query: 2750 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2571
              M FTSVTGHLMEL+F+DRYRKWHSCDPVDLY+APV+KYVPEDK +I++TLE EAR CQ
Sbjct: 60   CQMLFTSVTGHLMELEFDDRYRKWHSCDPVDLYNAPVRKYVPEDKLDIKRTLEAEARSCQ 119

Query: 2570 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFS 2391
            W+ILWLDCDREGENIAFEV++VC +AN NLN+WRAR SALIDREIH SVQ LV+PNQLFS
Sbjct: 120  WIILWLDCDREGENIAFEVLDVCRQANNNLNVWRARFSALIDREIHQSVQTLVQPNQLFS 179

Query: 2390 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFW 2211
            DAVD RQEIDLRIGASFTRFQTMLLR+AFVLD A D+ NV+LSYGPCQFPTLGF+VER+W
Sbjct: 180  DAVDVRQEIDLRIGASFTRFQTMLLRNAFVLDVAMDDRNVVLSYGPCQFPTLGFVVERYW 239

Query: 2210 EVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQ 2031
            E+Q+HEPEEFWTINCTHNS+EG ATFNWMRGHLFDY+C +IIYEMC+QEPTATVT V+QQ
Sbjct: 240  EIQAHEPEEFWTINCTHNSDEGIATFNWMRGHLFDYSCGVIIYEMCIQEPTATVTKVKQQ 299

Query: 2030 EKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLH 1851
            EKLKYPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQ GFISYPRTETDCFS +TDL 
Sbjct: 300  EKLKYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQNGFISYPRTETDCFSEKTDLC 359

Query: 1850 TIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHH 1671
            T+VQEQ GHPVWGSYAQRLLDPE  LW+NPSGGGHDDKAHPPIHPTKFSAGES WS DHH
Sbjct: 360  TMVQEQGGHPVWGSYAQRLLDPELGLWKNPSGGGHDDKAHPPIHPTKFSAGESRWSQDHH 419

Query: 1670 KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMI 1491
            +VYELVVRHFLACVSQPA+GAET VEIDIAGE FSA GRVI+AKNYLDVYRFE+WGGS+I
Sbjct: 420  RVYELVVRHFLACVSQPAVGAETIVEIDIAGESFSACGRVILAKNYLDVYRFESWGGSVI 479

Query: 1490 PTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 1311
            PTY++GQQFTPTTLTLD+GVTRPPPLLSEADLL CMDKAGIGTDATMHDHIKKLLDRFYA
Sbjct: 480  PTYSFGQQFTPTTLTLDSGVTRPPPLLSEADLLGCMDKAGIGTDATMHDHIKKLLDRFYA 539

Query: 1310 TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQ 1131
             KDS+ RFSPTKLGEALVMGYDDMGYELWKPYLRAMME DMKAVS+GTKRKAEVLE CLQ
Sbjct: 540  IKDSNTRFSPTKLGEALVMGYDDMGYELWKPYLRAMMECDMKAVSIGTKRKAEVLETCLQ 599

Query: 1130 QMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPD 951
            QMKACF+DAR N+GKLFEAMA+FFE SNRS+  E  A+G VVR+CGLC ESDMVLR+K D
Sbjct: 600  QMKACFLDARTNRGKLFEAMAIFFESSNRSSGGELQAVGGVVRRCGLCLESDMVLRQKSD 659

Query: 950  GNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVN 771
            G+FMVGCLG+PQCRN VWLPGSVSEA VT N C++CSPGPV+ IQFKFRRLEIPPNY+V 
Sbjct: 660  GSFMVGCLGYPQCRNAVWLPGSVSEAFVTENTCTSCSPGPVFKIQFKFRRLEIPPNYSVQ 719

Query: 770  HLGCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSS 591
            HLGCIGGCDDILRQLVE+CGTGSR++S+                        +      +
Sbjct: 720  HLGCIGGCDDILRQLVEICGTGSRSSSNPLGRGRGNPTSSSSAQRGNSRAQSSCAYCRQA 779

Query: 590  GSYAN--APESSRGRNSRSQEA----GESSIPCSSCGAPCNLRTANTPANRGRKFYSCQA 429
            G  +N    + S GR + SQE     GE SIPC+SCGAPC LRTANT  NRGRKF+SCQ+
Sbjct: 780  GHLSNDCPSQGSCGRTALSQEVDLQNGEPSIPCNSCGAPCILRTANTANNRGRKFFSCQS 839

Query: 428  QGCNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPIS 249
            QGCNFFVWEDN + G    R                             SF++ATGEPI+
Sbjct: 840  QGCNFFVWEDNLTRG----RAERANTSASTSSGRGGRGRGQGGAYPSSVSFVAATGEPIT 895

Query: 248  GRCFVCGDPGHFANACPNRG 189
            GRCF+CGDPGHFAN CP RG
Sbjct: 896  GRCFICGDPGHFANVCPRRG 915


>ref|XP_010320982.1| PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Solanum
            lycopersicum]
          Length = 915

 Score = 1457 bits (3772), Expect = 0.0
 Identities = 704/920 (76%), Positives = 780/920 (84%), Gaps = 6/920 (0%)
 Frame = -2

Query: 2930 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2751
            MAGGGGR +R LNVAEKPSVAKAVSGILSK    GG+RVRDGRSRYN+IFEFNYTI+NQ 
Sbjct: 1    MAGGGGRVIRVLNVAEKPSVAKAVSGILSKN-QPGGIRVRDGRSRYNKIFEFNYTIRNQP 59

Query: 2750 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2571
              M FTSVTGHLME++F +RYRKWHSCDP+DLY+AP++K+VPEDK +I++TLE EAR CQ
Sbjct: 60   CQMLFTSVTGHLMEIEFHERYRKWHSCDPLDLYNAPIRKFVPEDKLDIKRTLEAEARSCQ 119

Query: 2570 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFS 2391
            W+ILWLDCDREGENIAFEV++VC +AN NL +WRAR SALIDREIH SVQ LV+PNQLFS
Sbjct: 120  WIILWLDCDREGENIAFEVLDVCRQANHNLTVWRARFSALIDREIHQSVQTLVQPNQLFS 179

Query: 2390 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFW 2211
            DAVD RQEIDLRIGASFTRFQTMLLR AFVLDFATD+ N++LSYGPCQFPTLGF+VER+W
Sbjct: 180  DAVDVRQEIDLRIGASFTRFQTMLLRGAFVLDFATDDRNLVLSYGPCQFPTLGFVVERYW 239

Query: 2210 EVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQ 2031
            E+Q+HEPEEFWTINCTHNS+EGTATFNWMRGHLFDYTC ++IYEMC+QEP ATVT V+QQ
Sbjct: 240  EIQAHEPEEFWTINCTHNSDEGTATFNWMRGHLFDYTCGVMIYEMCIQEPIATVTKVKQQ 299

Query: 2030 EKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLH 1851
            EKLKYPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQ GFISYPRTETDCFS +TDL 
Sbjct: 300  EKLKYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQNGFISYPRTETDCFSDKTDLR 359

Query: 1850 TIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHH 1671
            T+VQEQ+GHPVWG+YAQRLLDP++ LWRNPSGGGHDDKAHPPIHPTKFSAGE+ WS DHH
Sbjct: 360  TMVQEQEGHPVWGTYAQRLLDPQSGLWRNPSGGGHDDKAHPPIHPTKFSAGETRWSQDHH 419

Query: 1670 KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMI 1491
            +VYELVVRHFLACVSQPA+GAET VEIDIAGE FSA GRVI+AKNYLDVYRFE+WGGS+I
Sbjct: 420  RVYELVVRHFLACVSQPAVGAETIVEIDIAGESFSACGRVILAKNYLDVYRFESWGGSVI 479

Query: 1490 PTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 1311
            PTY++GQQFTPTTLTLD+GV RPPPLLSEADLL CMDKAGIGTDATMHDHIKKLLDRFYA
Sbjct: 480  PTYSFGQQFTPTTLTLDSGVIRPPPLLSEADLLGCMDKAGIGTDATMHDHIKKLLDRFYA 539

Query: 1310 TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQ 1131
             KDS+ RFSPTKLGEALVMGYDDMGYELWKPYLRAMME DMKAVS GTKRKAEVLE CLQ
Sbjct: 540  IKDSNTRFSPTKLGEALVMGYDDMGYELWKPYLRAMMECDMKAVSTGTKRKAEVLETCLQ 599

Query: 1130 QMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPD 951
            QMKACF DAR NK KL EAMA+FFERSNRS+S EQ A+G VVR+CGLC ESDMVLR+KPD
Sbjct: 600  QMKACFSDARTNKEKLLEAMAIFFERSNRSSSGEQQAVGAVVRRCGLCLESDMVLRQKPD 659

Query: 950  GNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVN 771
            GNFMVGCLG+PQCRNVVWLPGSVSEA VT N C TCSPGPV+ IQFKFR+ EIPP+Y+V 
Sbjct: 660  GNFMVGCLGYPQCRNVVWLPGSVSEASVTENTCITCSPGPVFKIQFKFRQQEIPPDYSVQ 719

Query: 770  HLGCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAW----QT 603
            HLGCIGGCDDILRQLVE+CGTGSRN+S+                        +     QT
Sbjct: 720  HLGCIGGCDDILRQLVEICGTGSRNSSNPSGRGRGNPTAFSSAQRDNSRAQSSCAYCRQT 779

Query: 602  GHSSGSYANAPESSRGRNSRSQEA--GESSIPCSSCGAPCNLRTANTPANRGRKFYSCQA 429
            GH S    +  ++SR R +R+QE   GESS+PC+SCGAPC LRTANT  NRGRKF+SCQ+
Sbjct: 780  GHLSNDCPS--QASRDRTARAQEVDNGESSMPCNSCGAPCILRTANTANNRGRKFFSCQS 837

Query: 428  QGCNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPIS 249
              CNFFVWEDN  SGG   R +                           SF+SATGEPI+
Sbjct: 838  SECNFFVWEDNL-SGGRAERAN-TSASTSSGRGGRGRGRGQSGAHSSNVSFVSATGEPIT 895

Query: 248  GRCFVCGDPGHFANACPNRG 189
             RCF+CGDPGHFAN CP RG
Sbjct: 896  VRCFICGDPGHFANVCPRRG 915


>ref|XP_009622050.1| PREDICTED: DNA topoisomerase 3-alpha isoform X2 [Nicotiana
            tomentosiformis]
          Length = 900

 Score = 1421 bits (3679), Expect = 0.0
 Identities = 687/920 (74%), Positives = 764/920 (83%), Gaps = 8/920 (0%)
 Frame = -2

Query: 2924 GGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVH 2745
            GGGGR +R LNVAEKPSVAKAVSGILS+    GG+RVRDGRSRYN+IFEFNYTI+NQ   
Sbjct: 5    GGGGRVIRVLNVAEKPSVAKAVSGILSRN-QGGGMRVRDGRSRYNKIFEFNYTIRNQPCQ 63

Query: 2744 MSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWL 2565
            M FTSVTGHLMEL+F+DR+RKWHSCDP+ LY APV+KYVP+DK +I++TLEEEA +CQW+
Sbjct: 64   MLFTSVTGHLMELEFDDRFRKWHSCDPLHLYDAPVRKYVPQDKLDIKRTLEEEASRCQWI 123

Query: 2564 ILWLDCDREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFSDA 2385
            ILWLDCDREGENIAFEV+EVC +AN NLN+WRAR SALIDREIH S Q LV+PNQLFSDA
Sbjct: 124  ILWLDCDREGENIAFEVLEVCRQANHNLNVWRARFSALIDREIHQSAQTLVQPNQLFSDA 183

Query: 2384 VDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEV 2205
            VD RQEIDLRIGASFTRFQTMLLRDAFVLDFATD+ N++LSYGPCQFPTLGF+VER+WE+
Sbjct: 184  VDVRQEIDLRIGASFTRFQTMLLRDAFVLDFATDDRNLVLSYGPCQFPTLGFVVERYWEI 243

Query: 2204 QSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEK 2025
            Q+HEPEEFWTINCTHN +EG+ATFNWMRGHLFDYTCA+ IYEMC+QEPTATV+ V+QQEK
Sbjct: 244  QAHEPEEFWTINCTHNFDEGSATFNWMRGHLFDYTCAVTIYEMCIQEPTATVSKVKQQEK 303

Query: 2024 LKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTI 1845
            LKYPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQ GFISYPRTETDCFS +TDL T+
Sbjct: 304  LKYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQNGFISYPRTETDCFSEKTDLRTM 363

Query: 1844 VQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKV 1665
            VQEQ GHPVWGSYAQRLLDP++ LWRNPSGGGHDDKAHPPIHPTKFSAGES WS DHH+V
Sbjct: 364  VQEQGGHPVWGSYAQRLLDPQSGLWRNPSGGGHDDKAHPPIHPTKFSAGESRWSQDHHRV 423

Query: 1664 YELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPT 1485
            YELVVRHFLACVS+PA+GAETTVEIDIAGE F A GRVI+AKNYLDVYRFE+WGGS+IPT
Sbjct: 424  YELVVRHFLACVSKPAVGAETTVEIDIAGESFFACGRVILAKNYLDVYRFESWGGSVIPT 483

Query: 1484 YNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATK 1305
            Y +GQQF PT+LTLD+GVTRPPPLLSEADLL CMDKAGIGTDATMHDHIKKLLDRFYA K
Sbjct: 484  YTFGQQFIPTSLTLDSGVTRPPPLLSEADLLGCMDKAGIGTDATMHDHIKKLLDRFYAIK 543

Query: 1304 DSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQM 1125
            DSS RFSPTKLGEALVMGYDDMGYELWKPYLRAMME DMKAVSMGTKRK EVLE CLQQM
Sbjct: 544  DSSTRFSPTKLGEALVMGYDDMGYELWKPYLRAMMECDMKAVSMGTKRKTEVLETCLQQM 603

Query: 1124 KACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGN 945
            KACF+DAR NKGKLFEAMA+FFERSNRS+  EQ A+G+VVR+CGLC ESDMVLR+KP   
Sbjct: 604  KACFLDARANKGKLFEAMAIFFERSNRSSGGEQQAVGDVVRRCGLCLESDMVLRQKP--- 660

Query: 944  FMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHL 765
                      CRNVVWLPGS+SEA VT N C++C PGPVY IQF+FRRLEIPPNY+  H+
Sbjct: 661  ----------CRNVVWLPGSLSEASVTENTCTSCGPGPVYKIQFRFRRLEIPPNYSAQHI 710

Query: 764  GCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAW----QTGH 597
            GCIGGCDDILRQLVE+CGTGSR++S+                        +     QTGH
Sbjct: 711  GCIGGCDDILRQLVEICGTGSRSSSNTFGRGRGNPRASSSAQRGNSRAQGSCAYCRQTGH 770

Query: 596  SSGSYANAPESSRGRNSRSQEA----GESSIPCSSCGAPCNLRTANTPANRGRKFYSCQA 429
             S    +  ++SR R +RSQE     GE  IPC+SCG PCNLRTANT  NRGRKF+SCQ+
Sbjct: 771  LSNDCPS--QASRSRTARSQEVDLQNGEPLIPCNSCGEPCNLRTANTANNRGRKFFSCQS 828

Query: 428  QGCNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPIS 249
            + CNFFVWED  + G      +                           SF+SATGEPI+
Sbjct: 829  RECNFFVWEDTLNGGERTNTSA--------STSSRRGGRGQGGPNTSGVSFVSATGEPIT 880

Query: 248  GRCFVCGDPGHFANACPNRG 189
            GRCF+CGDPGHFAN CP RG
Sbjct: 881  GRCFICGDPGHFANVCPRRG 900


>ref|XP_010649354.1| PREDICTED: DNA topoisomerase 3-alpha isoform X2 [Vitis vinifera]
          Length = 918

 Score = 1417 bits (3669), Expect = 0.0
 Identities = 685/920 (74%), Positives = 766/920 (83%), Gaps = 14/920 (1%)
 Frame = -2

Query: 2906 LRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHMSFTSV 2727
            ++ LNVAEKPSVAKAV+ ILS+     GLRVR+GRSRYN++FEFNY+I+ Q   M  TSV
Sbjct: 1    MKVLNVAEKPSVAKAVATILSRNQ---GLRVREGRSRYNKLFEFNYSIRGQHCQMVVTSV 57

Query: 2726 TGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLILWLDC 2547
             GHLMEL+FEDR+RKWHSCDP  LYHAPV+K+VPEDK +I++TLEEEARKCQWL+LWLDC
Sbjct: 58   IGHLMELEFEDRFRKWHSCDPAHLYHAPVRKFVPEDKLDIKRTLEEEARKCQWLVLWLDC 117

Query: 2546 DREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFSDAVDARQE 2367
            DREGENIAFEV+EVC + NR++++WRAR SALIDREIH SVQ+LVRPNQLF+DAVD RQE
Sbjct: 118  DREGENIAFEVLEVCAQVNRHIDVWRARFSALIDREIHESVQNLVRPNQLFADAVDVRQE 177

Query: 2366 IDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEVQSHEPE 2187
            IDLRIGASFTRFQTMLLRDAFVLDFA D+ N++LSYGPCQFPTLGF+VER+WE+QSHEPE
Sbjct: 178  IDLRIGASFTRFQTMLLRDAFVLDFAADDRNLVLSYGPCQFPTLGFVVERYWEIQSHEPE 237

Query: 2186 EFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEKLKYPPH 2007
            EFWTINC+H S+EGT+TFNWMR HLFDYTCA+IIYEMC+QEPTATVT VRQQEKLKYPPH
Sbjct: 238  EFWTINCSHKSDEGTSTFNWMRAHLFDYTCAVIIYEMCIQEPTATVTKVRQQEKLKYPPH 297

Query: 2006 PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTIVQEQQG 1827
            PL+TIELEKRASRYF MSSEHTMKVAEDLYQ GFISYPRTETD FS RTDLH IVQEQ G
Sbjct: 298  PLNTIELEKRASRYFHMSSEHTMKVAEDLYQTGFISYPRTETDYFSERTDLHGIVQEQLG 357

Query: 1826 HPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKVYELVVR 1647
            HP+WGSYAQRLLDP A LWRNPS GGHDDKAHPPIHPTKFSAGESGWS DH ++YELVVR
Sbjct: 358  HPIWGSYAQRLLDPGAGLWRNPSNGGHDDKAHPPIHPTKFSAGESGWSQDHQRLYELVVR 417

Query: 1646 HFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPTYNYGQQ 1467
            HFLACVSQPA+GAET VEIDIAGE FS+SGRVIIAKNYLDVYRFE+WGGSMIPTY +GQQ
Sbjct: 418  HFLACVSQPAVGAETIVEIDIAGESFSSSGRVIIAKNYLDVYRFESWGGSMIPTYVFGQQ 477

Query: 1466 FTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSSMRF 1287
            F PTTLTLD+GVTRPPPLLSEADLL+CMDKAGIGTDATMHDHIKKLLDRFYATKDS+ RF
Sbjct: 478  FIPTTLTLDSGVTRPPPLLSEADLLNCMDKAGIGTDATMHDHIKKLLDRFYATKDSNTRF 537

Query: 1286 SPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQMKACFVD 1107
            SPT LGEALVMGYDDMGYELWKPYLR+MME DMKAVS+GTKR+ EVL  CL+QMKACF+D
Sbjct: 538  SPTNLGEALVMGYDDMGYELWKPYLRSMMECDMKAVSIGTKRRNEVLTTCLEQMKACFLD 597

Query: 1106 ARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGNFMVGCL 927
            ARLNK KL EAMA+FFERSNRS+ +EQH +G+VVR+C LCQESDMVLR+KPDGNFMVGCL
Sbjct: 598  ARLNKVKLLEAMALFFERSNRSSGDEQHEVGDVVRQCTLCQESDMVLRRKPDGNFMVGCL 657

Query: 926  GFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHLGCIGGC 747
            G+PQCRNVVWLPGS+SEA +TT  C+ C+PGPVY IQFKFRRLEIPPNYN++HLGC+ GC
Sbjct: 658  GYPQCRNVVWLPGSISEAAITTISCNHCTPGPVYKIQFKFRRLEIPPNYNIDHLGCVCGC 717

Query: 746  DDILRQLVEVCGTGSRNNSSV---XXXXXXXXXXXXXXXXXXXXXXXAWQTGHSSGSYAN 576
            D+ILRQL E+CGTGSR  S+V                            QTGHSS    +
Sbjct: 718  DEILRQLTEICGTGSRICSTVPARGRGSNASSTNAQRSNTRQTACIHCSQTGHSSNDCPS 777

Query: 575  APESSRGRNSR--SQEAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGCNFFVWE 402
                SR   S   +  +GESSIPC+ CG PC LRTANT  NRGRKFYSCQ+Q CNFFVWE
Sbjct: 778  RVPRSRNSQSHRTNMPSGESSIPCNVCGTPCILRTANTENNRGRKFYSCQSQECNFFVWE 837

Query: 401  D--NASSGG------TVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPISG 246
            D  N+SSGG      T    +                           +F+SATG+P+SG
Sbjct: 838  DSLNSSSGGRSAQPATARSSASNPSRRGGRGRGDRGRGRQSGARTSDTTFVSATGDPVSG 897

Query: 245  -RCFVCGDPGHFANACPNRG 189
             RCFVCGDP HFAN CPNRG
Sbjct: 898  RRCFVCGDPSHFANVCPNRG 917


>ref|XP_010649353.1| PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Vitis vinifera]
          Length = 919

 Score = 1417 bits (3669), Expect = 0.0
 Identities = 686/921 (74%), Positives = 767/921 (83%), Gaps = 15/921 (1%)
 Frame = -2

Query: 2906 LRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHMSFTSV 2727
            ++ LNVAEKPSVAKAV+ ILS+     GLRVR+GRSRYN++FEFNY+I+ Q   M  TSV
Sbjct: 1    MKVLNVAEKPSVAKAVATILSRNQ---GLRVREGRSRYNKLFEFNYSIRGQHCQMVVTSV 57

Query: 2726 TGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLILWLDC 2547
             GHLMEL+FEDR+RKWHSCDP  LYHAPV+K+VPEDK +I++TLEEEARKCQWL+LWLDC
Sbjct: 58   IGHLMELEFEDRFRKWHSCDPAHLYHAPVRKFVPEDKLDIKRTLEEEARKCQWLVLWLDC 117

Query: 2546 DREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFSDAVDARQE 2367
            DREGENIAFEV+EVC + NR++++WRAR SALIDREIH SVQ+LVRPNQLF+DAVD RQE
Sbjct: 118  DREGENIAFEVLEVCAQVNRHIDVWRARFSALIDREIHESVQNLVRPNQLFADAVDVRQE 177

Query: 2366 IDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEVQSHEPE 2187
            IDLRIGASFTRFQTMLLRDAFVLDFA D+ N++LSYGPCQFPTLGF+VER+WE+QSHEPE
Sbjct: 178  IDLRIGASFTRFQTMLLRDAFVLDFAADDRNLVLSYGPCQFPTLGFVVERYWEIQSHEPE 237

Query: 2186 EFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEKLKYPPH 2007
            EFWTINC+H S+EGT+TFNWMR HLFDYTCA+IIYEMC+QEPTATVT VRQQEKLKYPPH
Sbjct: 238  EFWTINCSHKSDEGTSTFNWMRAHLFDYTCAVIIYEMCIQEPTATVTKVRQQEKLKYPPH 297

Query: 2006 PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTIVQEQQG 1827
            PL+TIELEKRASRYF MSSEHTMKVAEDLYQ GFISYPRTETD FS RTDLH IVQEQ G
Sbjct: 298  PLNTIELEKRASRYFHMSSEHTMKVAEDLYQTGFISYPRTETDYFSERTDLHGIVQEQLG 357

Query: 1826 HPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKVYELVVR 1647
            HP+WGSYAQRLLDP A LWRNPS GGHDDKAHPPIHPTKFSAGESGWS DH ++YELVVR
Sbjct: 358  HPIWGSYAQRLLDPGAGLWRNPSNGGHDDKAHPPIHPTKFSAGESGWSQDHQRLYELVVR 417

Query: 1646 HFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPTYNYGQQ 1467
            HFLACVSQPA+GAET VEIDIAGE FS+SGRVIIAKNYLDVYRFE+WGGSMIPTY +GQQ
Sbjct: 418  HFLACVSQPAVGAETIVEIDIAGESFSSSGRVIIAKNYLDVYRFESWGGSMIPTYVFGQQ 477

Query: 1466 FTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSSMRF 1287
            F PTTLTLD+GVTRPPPLLSEADLL+CMDKAGIGTDATMHDHIKKLLDRFYATKDS+ RF
Sbjct: 478  FIPTTLTLDSGVTRPPPLLSEADLLNCMDKAGIGTDATMHDHIKKLLDRFYATKDSNTRF 537

Query: 1286 SPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQMKACFVD 1107
            SPT LGEALVMGYDDMGYELWKPYLR+MME DMKAVS+GTKR+ EVL  CL+QMKACF+D
Sbjct: 538  SPTNLGEALVMGYDDMGYELWKPYLRSMMECDMKAVSIGTKRRNEVLTTCLEQMKACFLD 597

Query: 1106 ARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGNFMVGCL 927
            ARLNK KL EAMA+FFERSNRS+ +EQH +G+VVR+C LCQESDMVLR+KPDGNFMVGCL
Sbjct: 598  ARLNKVKLLEAMALFFERSNRSSGDEQHEVGDVVRQCTLCQESDMVLRRKPDGNFMVGCL 657

Query: 926  GFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHLGCIGGC 747
            G+PQCRNVVWLPGS+SEA +TT  C+ C+PGPVY IQFKFRRLEIPPNYN++HLGC+ GC
Sbjct: 658  GYPQCRNVVWLPGSISEAAITTISCNHCTPGPVYKIQFKFRRLEIPPNYNIDHLGCVCGC 717

Query: 746  DDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAW----QTGHSSGSYA 579
            D+ILRQL E+CGTGSR  S+V                       A     QTGHSS    
Sbjct: 718  DEILRQLTEICGTGSRICSTVPAARGRGSNASSTNAQRSNTRQTACIHCSQTGHSSNDCP 777

Query: 578  NAPESSRGRNSR--SQEAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGCNFFVW 405
            +    SR   S   +  +GESSIPC+ CG PC LRTANT  NRGRKFYSCQ+Q CNFFVW
Sbjct: 778  SRVPRSRNSQSHRTNMPSGESSIPCNVCGTPCILRTANTENNRGRKFYSCQSQECNFFVW 837

Query: 404  ED--NASSGG------TVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPIS 249
            ED  N+SSGG      T    +                           +F+SATG+P+S
Sbjct: 838  EDSLNSSSGGRSAQPATARSSASNPSRRGGRGRGDRGRGRQSGARTSDTTFVSATGDPVS 897

Query: 248  G-RCFVCGDPGHFANACPNRG 189
            G RCFVCGDP HFAN CPNRG
Sbjct: 898  GRRCFVCGDPSHFANVCPNRG 918


>gb|OVA03617.1| DNA topoisomerase [Macleaya cordata]
          Length = 936

 Score = 1409 bits (3646), Expect = 0.0
 Identities = 684/935 (73%), Positives = 776/935 (82%), Gaps = 24/935 (2%)
 Frame = -2

Query: 2921 GGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHM 2742
            GGGR +R LNVAEKPSVAKAVSGILS+     GLRVR+GRSRYN+IFEF YTI+ Q  +M
Sbjct: 3    GGGRTIRVLNVAEKPSVAKAVSGILSRNQ---GLRVREGRSRYNKIFEFEYTIRGQPCNM 59

Query: 2741 SFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLI 2562
            + TSVTGHLMEL+FEDRYRKW+SCDPVDLY A V+K VP+DK +I++TLEEEAR+CQWL+
Sbjct: 60   AVTSVTGHLMELEFEDRYRKWNSCDPVDLYQAVVRKLVPQDKLDIKRTLEEEARRCQWLV 119

Query: 2561 LWLDCDREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFSDAV 2382
            LWLDCDREGENIAFEV+EVCT  N NLNIWRAR SALI+R+IH SVQ+LVRPNQLF+DAV
Sbjct: 120  LWLDCDREGENIAFEVIEVCTAVNPNLNIWRARFSALIERDIHESVQNLVRPNQLFADAV 179

Query: 2381 DARQEIDLRIGASFTRFQTMLLRDAFVLDFA-TDNTNVILSYGPCQFPTLGFIVERFWEV 2205
            DARQEIDLRIGASFTRFQTMLL+DAFVLD +  D  N++LSYGPCQFPTLGFIVER+WE+
Sbjct: 180  DARQEIDLRIGASFTRFQTMLLKDAFVLDGSGNDVRNMVLSYGPCQFPTLGFIVERYWEI 239

Query: 2204 QSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEK 2025
            Q+HEPEEFWTINCTH SE+GTATFNWMRGH+FDY+CA+IIYEMCVQEPTATVT VR Q+K
Sbjct: 240  QAHEPEEFWTINCTHTSEDGTATFNWMRGHMFDYSCAVIIYEMCVQEPTATVTKVRDQQK 299

Query: 2024 LKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTI 1845
            LK PP+PL+TIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETD FS RTDLH I
Sbjct: 300  LKQPPYPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDSFSERTDLHAI 359

Query: 1844 VQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKV 1665
            VQEQQGHPVWGSYAQ+LLDP A LWRNPS GGHDDKAHPPIHPTKFSAGESGWS DH++V
Sbjct: 360  VQEQQGHPVWGSYAQQLLDPGAGLWRNPSNGGHDDKAHPPIHPTKFSAGESGWSQDHNRV 419

Query: 1664 YELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPT 1485
            YELVVRHFLACVSQPA+GAETTVEIDIAGE FS SGR+IIA+NYLDVYRFE+WGGS+IP 
Sbjct: 420  YELVVRHFLACVSQPAVGAETTVEIDIAGELFSVSGRMIIARNYLDVYRFESWGGSVIPK 479

Query: 1484 YNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATK 1305
            Y +GQQFTPTTLTLD+GVTRPPPLLSEADLL+CMDKAGIGTDATMHDHIKKLLDRFYATK
Sbjct: 480  YLFGQQFTPTTLTLDSGVTRPPPLLSEADLLTCMDKAGIGTDATMHDHIKKLLDRFYATK 539

Query: 1304 DSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQM 1125
            D++ RFSPT LGEALVMGYDDMGY+LWKPYLR+MME DMKAVS+GTKRK+EVLE CLQQM
Sbjct: 540  DANTRFSPTNLGEALVMGYDDMGYKLWKPYLRSMMECDMKAVSLGTKRKSEVLETCLQQM 599

Query: 1124 KACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGN 945
            KACF+DARL K KL EAMA+FF+RSNRS+ +EQH  GEVVR+C +CQESDMVL++KPDGN
Sbjct: 600  KACFLDARLQKVKLLEAMAIFFDRSNRSSGDEQHVGGEVVRQCAVCQESDMVLKRKPDGN 659

Query: 944  FMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHL 765
            FMVGCLG+PQCRNVVWLP S+SEA VTT +C++C+PGPV++IQFKFR++EIPPNYNVNHL
Sbjct: 660  FMVGCLGYPQCRNVVWLPASISEATVTTQVCNSCNPGPVFMIQFKFRQMEIPPNYNVNHL 719

Query: 764  GCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAW---QTGHS 594
            GCIGGCD+ LRQL E+CGTGSR++SS+                            QTGHS
Sbjct: 720  GCIGGCDETLRQLREICGTGSRSSSSIPARGHGPTASSNTTQRPSTRQGTCTHCRQTGHS 779

Query: 593  SGSYANAPESSRGRNSRSQ--EAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGC 420
            S    +    S+   SR++  ++GE S+ C++CGA C LR ANT  NRGRKFYSCQ++ C
Sbjct: 780  SNDCPSQTLHSQSVQSRARNFQSGEPSVMCTTCGAACPLREANTTNNRGRKFYSCQSRDC 839

Query: 419  NFFVWEDN-----------------ASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXX 291
            NFFVW DN                 ++S     RGS                        
Sbjct: 840  NFFVWADNVNSSTGAEDMSSSRPATSNSSSGARRGSRGRGRSSGRGGGRSSRAAAGRAST 899

Query: 290  XXXSFMSATGEPISGR-CFVCGDPGHFANACPNRG 189
               +F+SATGEPISGR CFVCGDP HFAN CP+RG
Sbjct: 900  TGGTFVSATGEPISGRRCFVCGDPSHFANNCPSRG 934


>ref|XP_023917748.1| DNA topoisomerase 3-alpha isoform X2 [Quercus suber]
 gb|POF03697.1| dna topoisomerase 3-alpha [Quercus suber]
          Length = 924

 Score = 1406 bits (3640), Expect = 0.0
 Identities = 680/925 (73%), Positives = 762/925 (82%), Gaps = 11/925 (1%)
 Frame = -2

Query: 2930 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2751
            M+GGG   ++ L+VAEKPSVAK+V+ ILS+  ++GGLR R+GRSRYN+IFEF+Y+I  + 
Sbjct: 1    MSGGGRGGMKVLHVAEKPSVAKSVATILSR--NNGGLRTREGRSRYNKIFEFSYSINGRP 58

Query: 2750 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2571
             HM  TSVTGHLMEL+F+DRYRKWHSCDP DL+HAPV K+VPEDK +I++TLEEEAR CQ
Sbjct: 59   CHMLVTSVTGHLMELEFQDRYRKWHSCDPADLFHAPVHKFVPEDKLDIKRTLEEEARWCQ 118

Query: 2570 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFS 2391
            WL+LWLDCDREGENIAFEV+EVCT  N +L I RA  SALIDREIH +VQ LV PN+ F+
Sbjct: 119  WLVLWLDCDREGENIAFEVIEVCTAVNPHLTIKRAHFSALIDREIHEAVQCLVEPNKCFA 178

Query: 2390 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFW 2211
            DAVDARQEIDLRIGASFTRFQTMLLRDAFV+DF TD+ N++LSYGPCQFPTLGF+VER+W
Sbjct: 179  DAVDARQEIDLRIGASFTRFQTMLLRDAFVIDFTTDDRNLVLSYGPCQFPTLGFVVERYW 238

Query: 2210 EVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQ 2031
            E+Q+HEPEEFWTINC+H S+EG ATFNWMRGHLFDYTCA+IIYEMCVQEP ATVT VRQQ
Sbjct: 239  EIQAHEPEEFWTINCSHKSDEGIATFNWMRGHLFDYTCAVIIYEMCVQEPIATVTKVRQQ 298

Query: 2030 EKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLH 1851
            EKLKYPP+PL+TIELEKRASR+FRMSSEHTMKVAEDLYQAGFISYPRTETD FS RTDLH
Sbjct: 299  EKLKYPPYPLNTIELEKRASRFFRMSSEHTMKVAEDLYQAGFISYPRTETDSFSQRTDLH 358

Query: 1850 TIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHH 1671
             IVQEQQ HPVWG YAQ+LL+P + LWRNP  GGHDDKAHPPIHPTKFS+GESGWS DHH
Sbjct: 359  AIVQEQQRHPVWGPYAQQLLEPGSGLWRNPGNGGHDDKAHPPIHPTKFSSGESGWSQDHH 418

Query: 1670 KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMI 1491
            ++YELVVRHFLACVSQPA+GAET VEIDIAGE FSASGR I+AKNYLDVYRFE+WG S I
Sbjct: 419  RLYELVVRHFLACVSQPAVGAETNVEIDIAGELFSASGRAILAKNYLDVYRFESWGSSTI 478

Query: 1490 PTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 1311
            PTY  GQQF PT+LTLD+GVTRPPPLLSEADLLSCMDK GIGTDATMHDHIKKLLDRFYA
Sbjct: 479  PTYVSGQQFVPTSLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYA 538

Query: 1310 TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQ 1131
            TKD +MRFSPT LGEALVMGYDDMGY+LWKPYLRA+ME DMKAVS GTK KAEVL   LQ
Sbjct: 539  TKDPNMRFSPTNLGEALVMGYDDMGYKLWKPYLRAVMERDMKAVSEGTKSKAEVLTTSLQ 598

Query: 1130 QMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPD 951
            QMKACFVDARLNK KLFEAMAVFFERSNRS  +EQHA GEVVR CGLCQESDMVLR+  D
Sbjct: 599  QMKACFVDARLNKVKLFEAMAVFFERSNRSGGDEQHAAGEVVRPCGLCQESDMVLRRNRD 658

Query: 950  GNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVN 771
            GNFMVGC+G+PQCRN VWLPGS+SEA+VTTNIC+TC+PGPVY+IQFKFR LEIPPNYN +
Sbjct: 659  GNFMVGCMGYPQCRNAVWLPGSLSEAVVTTNICNTCTPGPVYMIQFKFRPLEIPPNYNAS 718

Query: 770  HLGCIGGCDDILRQLVEVCGTGSR----NNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQT 603
            HLGCIGGCD+ILRQL+E+CGTGSR       S                          QT
Sbjct: 719  HLGCIGGCDEILRQLIEICGTGSRIPARGRGSSAPASNVQQSNSRHGEARHSACIYCHQT 778

Query: 602  GHSSGSYANAPESSRGRNSRSQ--EAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQA 429
            GHSS    +    SR    R    ++GE S+PCS+CG PC LRTANT  NRGRKFYSCQ+
Sbjct: 779  GHSSSDCPSQVSGSRSSRHRGMNPQSGEPSVPCSTCGTPCILRTANTANNRGRKFYSCQS 838

Query: 428  QGCNFFVWEDNAS--SGGTVPRG--SIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATG 261
            Q CNFFVWEDN +  +GG V RG  S+                          +F+SATG
Sbjct: 839  QECNFFVWEDNLNNVTGGNVQRGRTSVSASNTSRSGGRGRGGRGGSRAATATATFVSATG 898

Query: 260  EPISG-RCFVCGDPGHFANACPNRG 189
            +P++G RCFVCGDP HFAN CPNRG
Sbjct: 899  DPVTGRRCFVCGDPSHFANVCPNRG 923


>ref|XP_023917747.1| DNA topoisomerase 3-alpha isoform X1 [Quercus suber]
          Length = 937

 Score = 1397 bits (3616), Expect = 0.0
 Identities = 680/938 (72%), Positives = 762/938 (81%), Gaps = 24/938 (2%)
 Frame = -2

Query: 2930 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2751
            M+GGG   ++ L+VAEKPSVAK+V+ ILS+  ++GGLR R+GRSRYN+IFEF+Y+I  + 
Sbjct: 1    MSGGGRGGMKVLHVAEKPSVAKSVATILSR--NNGGLRTREGRSRYNKIFEFSYSINGRP 58

Query: 2750 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2571
             HM  TSVTGHLMEL+F+DRYRKWHSCDP DL+HAPV K+VPEDK +I++TLEEEAR CQ
Sbjct: 59   CHMLVTSVTGHLMELEFQDRYRKWHSCDPADLFHAPVHKFVPEDKLDIKRTLEEEARWCQ 118

Query: 2570 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFS 2391
            WL+LWLDCDREGENIAFEV+EVCT  N +L I RA  SALIDREIH +VQ LV PN+ F+
Sbjct: 119  WLVLWLDCDREGENIAFEVIEVCTAVNPHLTIKRAHFSALIDREIHEAVQCLVEPNKCFA 178

Query: 2390 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQ------------ 2247
            DAVDARQEIDLRIGASFTRFQTMLLRDAFV+DF TD+ N++LSYGPCQ            
Sbjct: 179  DAVDARQEIDLRIGASFTRFQTMLLRDAFVIDFTTDDRNLVLSYGPCQRDASLLHLSPYV 238

Query: 2246 -FPTLGFIVERFWEVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCV 2070
             FPTLGF+VER+WE+Q+HEPEEFWTINC+H S+EG ATFNWMRGHLFDYTCA+IIYEMCV
Sbjct: 239  QFPTLGFVVERYWEIQAHEPEEFWTINCSHKSDEGIATFNWMRGHLFDYTCAVIIYEMCV 298

Query: 2069 QEPTATVTNVRQQEKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPR 1890
            QEP ATVT VRQQEKLKYPP+PL+TIELEKRASR+FRMSSEHTMKVAEDLYQAGFISYPR
Sbjct: 299  QEPIATVTKVRQQEKLKYPPYPLNTIELEKRASRFFRMSSEHTMKVAEDLYQAGFISYPR 358

Query: 1889 TETDCFSVRTDLHTIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTK 1710
            TETD FS RTDLH IVQEQQ HPVWG YAQ+LL+P + LWRNP  GGHDDKAHPPIHPTK
Sbjct: 359  TETDSFSQRTDLHAIVQEQQRHPVWGPYAQQLLEPGSGLWRNPGNGGHDDKAHPPIHPTK 418

Query: 1709 FSAGESGWSPDHHKVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYL 1530
            FS+GESGWS DHH++YELVVRHFLACVSQPA+GAET VEIDIAGE FSASGR I+AKNYL
Sbjct: 419  FSSGESGWSQDHHRLYELVVRHFLACVSQPAVGAETNVEIDIAGELFSASGRAILAKNYL 478

Query: 1529 DVYRFETWGGSMIPTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATM 1350
            DVYRFE+WG S IPTY  GQQF PT+LTLD+GVTRPPPLLSEADLLSCMDK GIGTDATM
Sbjct: 479  DVYRFESWGSSTIPTYVSGQQFVPTSLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATM 538

Query: 1349 HDHIKKLLDRFYATKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMG 1170
            HDHIKKLLDRFYATKD +MRFSPT LGEALVMGYDDMGY+LWKPYLRA+ME DMKAVS G
Sbjct: 539  HDHIKKLLDRFYATKDPNMRFSPTNLGEALVMGYDDMGYKLWKPYLRAVMERDMKAVSEG 598

Query: 1169 TKRKAEVLEACLQQMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGL 990
            TK KAEVL   LQQMKACFVDARLNK KLFEAMAVFFERSNRS  +EQHA GEVVR CGL
Sbjct: 599  TKSKAEVLTTSLQQMKACFVDARLNKVKLFEAMAVFFERSNRSGGDEQHAAGEVVRPCGL 658

Query: 989  CQESDMVLRKKPDGNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFK 810
            CQESDMVLR+  DGNFMVGC+G+PQCRN VWLPGS+SEA+VTTNIC+TC+PGPVY+IQFK
Sbjct: 659  CQESDMVLRRNRDGNFMVGCMGYPQCRNAVWLPGSLSEAVVTTNICNTCTPGPVYMIQFK 718

Query: 809  FRRLEIPPNYNVNHLGCIGGCDDILRQLVEVCGTGSR----NNSSVXXXXXXXXXXXXXX 642
            FR LEIPPNYN +HLGCIGGCD+ILRQL+E+CGTGSR       S               
Sbjct: 719  FRPLEIPPNYNASHLGCIGGCDEILRQLIEICGTGSRIPARGRGSSAPASNVQQSNSRHG 778

Query: 641  XXXXXXXXXAWQTGHSSGSYANAPESSRGRNSRSQ--EAGESSIPCSSCGAPCNLRTANT 468
                       QTGHSS    +    SR    R    ++GE S+PCS+CG PC LRTANT
Sbjct: 779  EARHSACIYCHQTGHSSSDCPSQVSGSRSSRHRGMNPQSGEPSVPCSTCGTPCILRTANT 838

Query: 467  PANRGRKFYSCQAQGCNFFVWEDNAS--SGGTVPRG--SIXXXXXXXXXXXXXXXXXXXX 300
              NRGRKFYSCQ+Q CNFFVWEDN +  +GG V RG  S+                    
Sbjct: 839  ANNRGRKFYSCQSQECNFFVWEDNLNNVTGGNVQRGRTSVSASNTSRSGGRGRGGRGGSR 898

Query: 299  XXXXXXSFMSATGEPISG-RCFVCGDPGHFANACPNRG 189
                  +F+SATG+P++G RCFVCGDP HFAN CPNRG
Sbjct: 899  AATATATFVSATGDPVTGRRCFVCGDPSHFANVCPNRG 936


>ref|XP_010270299.1| PREDICTED: DNA topoisomerase 3-alpha [Nelumbo nucifera]
          Length = 921

 Score = 1395 bits (3612), Expect = 0.0
 Identities = 677/922 (73%), Positives = 761/922 (82%), Gaps = 14/922 (1%)
 Frame = -2

Query: 2915 GRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHMSF 2736
            GR +R LNVAEKPSVAKAV+GILS+     GLRVR+GRSR+NRIFEF+Y+I+ Q  HM F
Sbjct: 4    GRTVRVLNVAEKPSVAKAVAGILSRNQ---GLRVRNGRSRFNRIFEFDYSIRGQHCHMLF 60

Query: 2735 TSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLILW 2556
            TSVTGHLMEL+FE+RYRKWHSCDP DLYHAPV+K+VP+DK +I++TLEEEARKCQWL+LW
Sbjct: 61   TSVTGHLMELEFEERYRKWHSCDPADLYHAPVRKFVPQDKLDIKRTLEEEARKCQWLVLW 120

Query: 2555 LDCDREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFSDAVDA 2376
            LDCDREGENIAFEVVE+C+ AN +LNIWRAR SALIDREIH SVQ+LVRPNQLF+DAVDA
Sbjct: 121  LDCDREGENIAFEVVEICSAANNHLNIWRARFSALIDREIHESVQNLVRPNQLFADAVDA 180

Query: 2375 RQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEVQSH 2196
            RQEIDLRIGASFTRFQTMLL+DAFV+DFATD+ N++LSYGPCQFPTLGF+VER+WE+Q+H
Sbjct: 181  RQEIDLRIGASFTRFQTMLLKDAFVIDFATDDRNLVLSYGPCQFPTLGFVVERYWEIQAH 240

Query: 2195 EPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEKLKY 2016
            EPEEFWTINC+H  +EG ATFNWMRGH+FDYT A+IIYEMC  EPTATVT V+ QEKLKY
Sbjct: 241  EPEEFWTINCSHTLDEGIATFNWMRGHIFDYTYAVIIYEMCTLEPTATVTKVKNQEKLKY 300

Query: 2015 PPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTIVQE 1836
            PPHPL+TIELEKRASRYFRMSSEHTMKVAE+LYQ+GFISYPRTETDCFS RTDLH +VQE
Sbjct: 301  PPHPLNTIELEKRASRYFRMSSEHTMKVAEELYQSGFISYPRTETDCFSARTDLHAMVQE 360

Query: 1835 QQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKVYEL 1656
            QQGHP+WGSYAQRLLDPEA LWR+PS GGHDDKAHPPIHPTK+SAGESGWS DHH++YEL
Sbjct: 361  QQGHPLWGSYAQRLLDPEARLWRSPSNGGHDDKAHPPIHPTKYSAGESGWSQDHHRLYEL 420

Query: 1655 VVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPTYNY 1476
            VVRHFLACVSQPAIGAET VEIDIAGEQFS SGRVI+ KNYLDVYRFE+WGGSMIPTY+ 
Sbjct: 421  VVRHFLACVSQPAIGAETIVEIDIAGEQFSVSGRVILQKNYLDVYRFESWGGSMIPTYSV 480

Query: 1475 GQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSS 1296
            GQQF PT LTLD+GVTRPPPLLSEADLL+CMDKAGIGTDATMHDHIKKLLDR YATKDS+
Sbjct: 481  GQQFIPTALTLDSGVTRPPPLLSEADLLNCMDKAGIGTDATMHDHIKKLLDRCYATKDSN 540

Query: 1295 MRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQMKAC 1116
             RFSPT LGEALVMGYDDMGYELWKPYLR+MME DMKAVS+GTKRKAEVLE CLQQMKAC
Sbjct: 541  TRFSPTNLGEALVMGYDDMGYELWKPYLRSMMECDMKAVSIGTKRKAEVLETCLQQMKAC 600

Query: 1115 FVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGNFMV 936
            F+DARLNK KL EAMA+FFER NR  +NEQ    ++VR C  CQES+MVL++KPDGNFMV
Sbjct: 601  FLDARLNKVKLLEAMAIFFERCNRPGTNEQQGAVDIVRPCSACQESNMVLKRKPDGNFMV 660

Query: 935  GCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHLGCI 756
            GCLGFPQCRNVVWLPGS+S A VT +IC +CSPGPV+ IQFKFRRLEIP +Y+V+HLGCI
Sbjct: 661  GCLGFPQCRNVVWLPGSISTATVTNHICDSCSPGPVFKIQFKFRRLEIPSDYDVDHLGCI 720

Query: 755  GGCDDILRQLVEVCGTGSRN---NSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSSG- 588
            GGCD+ L+QL E+CGTGSRN    S+                          QTGHSS  
Sbjct: 721  GGCDETLKQLTEICGTGSRNPPSTSARGRGTTASSTNAQRVSTMQGVCEHCRQTGHSSND 780

Query: 587  --SYANAPESSRGRNSRSQEAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGCNF 414
              +  +  +S R R   SQ  G SS+ C+SCG  C LRTANT  NRGRKFYSCQ   CNF
Sbjct: 781  CPTQVSRRQSVRPRGRNSQRGG-SSVSCNSCGTLCALRTANTANNRGRKFYSCQE--CNF 837

Query: 413  FVWED----NASSGGTVPRGS---IXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEP 255
            FVWED    N + G +VP  S                               F+SATGEP
Sbjct: 838  FVWEDSVNGNNTQGQSVPHASYRRAANSGSNSSRRGRRGRGGRSGASTTNTRFVSATGEP 897

Query: 254  ISG-RCFVCGDPGHFANACPNR 192
            +SG  C++CGDP HFAN CP+R
Sbjct: 898  VSGMSCYICGDPSHFANVCPDR 919


>gb|EOX92637.1| Topoisomerase 3alpha isoform 1 [Theobroma cacao]
          Length = 914

 Score = 1393 bits (3606), Expect = 0.0
 Identities = 674/913 (73%), Positives = 750/913 (82%), Gaps = 7/913 (0%)
 Frame = -2

Query: 2906 LRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHMSFTSV 2727
            ++ LNVAEKPSVAK+VSGILS+     GLRVRDGRSR+NRIFEFNY+++ Q  HM FTSV
Sbjct: 5    IKVLNVAEKPSVAKSVSGILSRNQ---GLRVRDGRSRFNRIFEFNYSVRGQPCHMLFTSV 61

Query: 2726 TGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLILWLDC 2547
            TGHLMEL+FEDR+RKWHSCDP DLYHAPV+K+VPEDK +I++TLEEEAR+CQWL+LWLDC
Sbjct: 62   TGHLMELEFEDRFRKWHSCDPADLYHAPVRKHVPEDKMDIKRTLEEEARRCQWLVLWLDC 121

Query: 2546 DREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFSDAVDARQE 2367
            DREGENIAFEV++VC   N +L I RAR SALI+REIH++ Q+LV PN  FSDAVDARQE
Sbjct: 122  DREGENIAFEVIDVCRAVNCHLTIRRARFSALIEREIHHATQNLVDPNPWFSDAVDARQE 181

Query: 2366 IDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEVQSHEPE 2187
            IDLRIGASFTRFQTM+LRD FV+D ATD+ N++LSYGPCQFPTLGF+VER+WEVQSHEPE
Sbjct: 182  IDLRIGASFTRFQTMMLRDKFVIDSATDDRNLVLSYGPCQFPTLGFVVERYWEVQSHEPE 241

Query: 2186 EFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEKLKYPPH 2007
            EFWTINC+H  +EG ATFNWMRGHLFD+TCA+I+YEMCVQEP ATVT VR QEKLKYPP+
Sbjct: 242  EFWTINCSHKLDEGVATFNWMRGHLFDHTCAVIVYEMCVQEPNATVTKVRHQEKLKYPPY 301

Query: 2006 PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTIVQEQQG 1827
            PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFS RTDLH IVQEQQ 
Sbjct: 302  PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSSRTDLHAIVQEQQD 361

Query: 1826 HPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKVYELVVR 1647
            HP WGSYAQRLLDP  SLWRNPS GGHDDKAHPPIHPTKFSAGE  WS DH K+YELVVR
Sbjct: 362  HPEWGSYAQRLLDPGTSLWRNPSSGGHDDKAHPPIHPTKFSAGEHNWSQDHRKLYELVVR 421

Query: 1646 HFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPTYNYGQQ 1467
            HFLACVSQPA+GAETTVEIDIA EQFS SGRVI+ +NYLDVYR+E+WGGSMIPTY  GQQ
Sbjct: 422  HFLACVSQPAVGAETTVEIDIADEQFSTSGRVILERNYLDVYRYESWGGSMIPTYTLGQQ 481

Query: 1466 FTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSSMRF 1287
            F PT+LTLD GVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDS+ RF
Sbjct: 482  FIPTSLTLDTGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSNTRF 541

Query: 1286 SPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQMKACFVD 1107
            SPTKLGEALVMGYDDMGYELWKP LR+MME DMK VS+G KRK EVL  CLQQMKACF+D
Sbjct: 542  SPTKLGEALVMGYDDMGYELWKPNLRSMMEFDMKEVSVGNKRKDEVLATCLQQMKACFLD 601

Query: 1106 ARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGNFMVGCL 927
            ARLNK KL EAMAVFFERSN+S  ++ H  GEVVR+CGLC+ES MVL+K  DGNFMVGCL
Sbjct: 602  ARLNKVKLLEAMAVFFERSNQSAGDDNHVAGEVVRQCGLCRESSMVLKKNRDGNFMVGCL 661

Query: 926  GFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHLGCIGGC 747
            GFPQCRN +WLPGSV EA VT+NIC +C+PGPVYLIQFKFR+LEIPP +N NHLGCIGGC
Sbjct: 662  GFPQCRNAIWLPGSVLEAAVTSNICGSCNPGPVYLIQFKFRQLEIPPGFNANHLGCIGGC 721

Query: 746  DDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSSGSYANAPE 567
            DDILRQL+E+CGTGSR  S+                          QTGHSS    +   
Sbjct: 722  DDILRQLIEICGTGSR-MSARGRGPTTTSSNVQRNSSRQGACLYCQQTGHSSNDCPSQFS 780

Query: 566  SSRGRNSR-SQEAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGCNFFVWED--- 399
             SR   SR S + GE S+ CS+CG PC LRTANT  NRGRKFYSC +Q CNFF+WED   
Sbjct: 781  GSRNSRSRTSSQNGEPSVSCSTCGTPCVLRTANTANNRGRKFYSCPSQECNFFIWEDEHN 840

Query: 398  NASSGGTVPRGSI--XXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPISG-RCFVCG 228
            N + G ++PR  I                            +F+SATG+PISG RC+VCG
Sbjct: 841  NGTGGRSIPRAGINGSASNSSRGGGRGRGRFGQNGARAADVTFVSATGDPISGRRCYVCG 900

Query: 227  DPGHFANACPNRG 189
            DP HFAN CPNRG
Sbjct: 901  DPSHFANVCPNRG 913


>ref|XP_024025914.1| DNA topoisomerase 3-alpha [Morus notabilis]
          Length = 913

 Score = 1392 bits (3603), Expect = 0.0
 Identities = 669/915 (73%), Positives = 760/915 (83%), Gaps = 6/915 (0%)
 Frame = -2

Query: 2921 GGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHM 2742
            GGGR + ALNVAEKPSVAK+V+ ILS+     G RVR+GRSRYN+IFEF Y+I    V M
Sbjct: 3    GGGRSITALNVAEKPSVAKSVATILSRNHQ--GFRVREGRSRYNKIFEFPYSINGVAVQM 60

Query: 2741 SFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLI 2562
              TSVTGHLME++FEDR+RKWHSCDP  L+ AP++K VP+DK +I++TLE+EAR+CQWLI
Sbjct: 61   LVTSVTGHLMEIEFEDRFRKWHSCDPAHLFQAPIRKSVPDDKLDIKRTLEDEARRCQWLI 120

Query: 2561 LWLDCDREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFSDAV 2382
            LWLDCDREGENIAFEV+ VCT AN +L + RAR SALIDREIH + Q+LV+PN+ F+DAV
Sbjct: 121  LWLDCDREGENIAFEVINVCTAANPHLTLRRARFSALIDREIHEAAQNLVQPNKFFADAV 180

Query: 2381 DARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEVQ 2202
            DARQEIDLRIGASFTRFQTMLLRDAFV+D ATD+ N++LSYGPCQFPTLGF+VER+WEVQ
Sbjct: 181  DARQEIDLRIGASFTRFQTMLLRDAFVIDSATDDRNLVLSYGPCQFPTLGFVVERYWEVQ 240

Query: 2201 SHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEKL 2022
            SHEPEEFW INC+H S+E  ATFNWMRGHLFDYTCA++IYEMCV+EPTATVTNVR+QEKL
Sbjct: 241  SHEPEEFWAINCSHRSDEVIATFNWMRGHLFDYTCAVVIYEMCVEEPTATVTNVRKQEKL 300

Query: 2021 KYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTIV 1842
            KYPP+PL+TIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFS RT+LH IV
Sbjct: 301  KYPPYPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTNLHAIV 360

Query: 1841 QEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKVY 1662
            +EQQGHP+WGSYAQRLLDP + LWRNP  GGHDDKAHPPIHPTKFSAGE  WS DH ++Y
Sbjct: 361  EEQQGHPIWGSYAQRLLDPGSGLWRNPGNGGHDDKAHPPIHPTKFSAGEPAWSQDHLRLY 420

Query: 1661 ELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPTY 1482
            ELVVRHFLACVSQPA+GAETTVEIDIAGE FSASGRV++AKNYLD+YRFE+WGGS+IPTY
Sbjct: 421  ELVVRHFLACVSQPAVGAETTVEIDIAGELFSASGRVVLAKNYLDIYRFESWGGSLIPTY 480

Query: 1481 NYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKD 1302
              GQQF PTTLTLD+GVTRPPPLLSEADLLSCMDK GIGTDATMHDHIKKLLDR YATKD
Sbjct: 481  VLGQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRCYATKD 540

Query: 1301 SSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQMK 1122
            ++ RFSPT LGEALVMGYDDMGY+LWKPYLRA+ME DMKAVS G K KAE+LE CLQQMK
Sbjct: 541  ANTRFSPTNLGEALVMGYDDMGYKLWKPYLRAVMERDMKAVSEGAKSKAELLETCLQQMK 600

Query: 1121 ACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGNF 942
            ACF+DARLNK KL E MA+FFERSNRS+ +EQH   EVVR CGLC ESDMVL++  DGNF
Sbjct: 601  ACFLDARLNKAKLLETMAIFFERSNRSSGDEQHGPVEVVRPCGLCHESDMVLKQNRDGNF 660

Query: 941  MVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHLG 762
            MVGC+G+PQCRNVVWLPGSVSEA VT+NIC++C+PGPV+LIQFKFRRLEIPP+YN +HLG
Sbjct: 661  MVGCMGYPQCRNVVWLPGSVSEAAVTSNICNSCTPGPVHLIQFKFRRLEIPPDYNASHLG 720

Query: 761  CIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSSG-- 588
            CIGGCD ILRQL+E+CGTG+R  S+                          QTGHSS   
Sbjct: 721  CIGGCDAILRQLIEICGTGTR-MSARGRGPTASSGSAQQTNTRQGVCIYCHQTGHSSSDC 779

Query: 587  -SYANAPESSRGRNSRSQEAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGCNFF 411
             S  +AP+S+R R +  Q +G+SSIPC +CGAPC LRTANT  NRGRKFYSCQ+Q CNFF
Sbjct: 780  PSQVSAPQSTRSRRANVQ-SGDSSIPCGTCGAPCPLRTANTANNRGRKFYSCQSQECNFF 838

Query: 410  VWED---NASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPISGRC 240
            VWED   N S G +VPR +                           +F+SATG+P SGRC
Sbjct: 839  VWEDSLSNGSGGRSVPRANTRAPASNSSRNGGHGRGGRGTTRGAGATFVSATGDPASGRC 898

Query: 239  FVCGDPGHFANACPN 195
            FVCGDP HFAN CPN
Sbjct: 899  FVCGDPSHFANVCPN 913


>ref|XP_007048480.2| PREDICTED: DNA topoisomerase 3-alpha isoform X2 [Theobroma cacao]
          Length = 916

 Score = 1391 bits (3600), Expect = 0.0
 Identities = 673/915 (73%), Positives = 751/915 (82%), Gaps = 9/915 (0%)
 Frame = -2

Query: 2906 LRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHMSFTSV 2727
            ++ LNVAEKPSVAK+VSGILS+     GLRVRDGRSR+NRIFEFNY+++ Q  HM FTSV
Sbjct: 5    IKVLNVAEKPSVAKSVSGILSRNQ---GLRVRDGRSRFNRIFEFNYSVRGQPCHMLFTSV 61

Query: 2726 TGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLILWLDC 2547
            TGHLMEL+FEDR+RKWHSCDP DLYHAPV+K+VPEDK +I++TLEEEAR+CQWL+LWLDC
Sbjct: 62   TGHLMELEFEDRFRKWHSCDPADLYHAPVRKHVPEDKMDIKRTLEEEARRCQWLVLWLDC 121

Query: 2546 DREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFSDAVDARQE 2367
            DREGENIAFEV++VC   N +L I RAR SALI+REIH++ Q+LV PN  FSDAVDARQE
Sbjct: 122  DREGENIAFEVIDVCRAVNCHLTIRRARFSALIEREIHHATQNLVDPNPWFSDAVDARQE 181

Query: 2366 IDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEVQSHEPE 2187
            IDLRIGASFTRFQTM+LRD FV+D ATD+ N++LSYGPCQFPTLGF+VER+WEVQSHEPE
Sbjct: 182  IDLRIGASFTRFQTMMLRDKFVIDSATDDRNLVLSYGPCQFPTLGFVVERYWEVQSHEPE 241

Query: 2186 EFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEKLKYPPH 2007
            EFWTINC+H  +EG ATFNWMRGHLFD+TCA+I+YEMCVQEP ATVT VR QEKLKYPP+
Sbjct: 242  EFWTINCSHKLDEGVATFNWMRGHLFDHTCAVIVYEMCVQEPNATVTKVRHQEKLKYPPY 301

Query: 2006 PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTIVQEQQG 1827
            PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFS RTDLH IVQEQQ 
Sbjct: 302  PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSSRTDLHAIVQEQQD 361

Query: 1826 HPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKVYELVVR 1647
            HP WGSYAQRLLDP  SLWRNPS GGHDDKAHPPIHPTKFSAGE  WS DH K+YELVVR
Sbjct: 362  HPEWGSYAQRLLDPGTSLWRNPSSGGHDDKAHPPIHPTKFSAGEHNWSQDHRKLYELVVR 421

Query: 1646 HFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPTYNYGQQ 1467
            HFLACVSQPA+GAETTVEIDIA EQFS SGRVI+ +NYLDVYR+E+WGGSMIPTY  GQQ
Sbjct: 422  HFLACVSQPAVGAETTVEIDIADEQFSTSGRVILERNYLDVYRYESWGGSMIPTYTLGQQ 481

Query: 1466 FTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSSMRF 1287
            F P +LTLD GVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDS+ RF
Sbjct: 482  FIPASLTLDTGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSNTRF 541

Query: 1286 SPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQMKACFVD 1107
            SPTKLGEALVMGYDDMGYELWKP LR+MME DMK VS+G KRK EVL  CLQQMKACF+D
Sbjct: 542  SPTKLGEALVMGYDDMGYELWKPNLRSMMEFDMKEVSVGNKRKDEVLATCLQQMKACFLD 601

Query: 1106 ARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGNFMVGCL 927
            ARLNK KL EAMAVFFERSN++  ++ HA GEVVR+CGLC+ES MVL+K  DGNFMVGCL
Sbjct: 602  ARLNKVKLLEAMAVFFERSNQAAGDDNHAAGEVVRQCGLCRESSMVLKKNRDGNFMVGCL 661

Query: 926  GFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHLGCIGGC 747
            GFPQCRN +WLPGSV EA VT+NIC +C+PGPVYLIQFKFR+LEIPP +N NHLGCIGGC
Sbjct: 662  GFPQCRNAIWLPGSVLEAAVTSNICGSCNPGPVYLIQFKFRQLEIPPGFNANHLGCIGGC 721

Query: 746  DDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSSGSYANAPE 567
            DDILRQL+E+CGTGSR  S+                          QTGHSS    +   
Sbjct: 722  DDILRQLIEICGTGSR-MSARGRGPTTTSSNVQRNSSRQGACLYCQQTGHSSNDCPSQFS 780

Query: 566  SSRGRNSR-SQEAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGCNFFVWED--- 399
             SR   SR + + GE S+ CS+CG PC LRTANT  NRGRKFYSC +Q CNFF+WED   
Sbjct: 781  GSRNSRSRTNSQNGEPSVLCSTCGTPCVLRTANTANNRGRKFYSCPSQECNFFIWEDEHN 840

Query: 398  NASSGGTVPR----GSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPISG-RCFV 234
            N + G ++PR    GS                           +F+SATG+PISG RC+V
Sbjct: 841  NGTGGRSIPRAGINGSASNSSRGGGRGRGRGRFGQNGARAADVTFVSATGDPISGRRCYV 900

Query: 233  CGDPGHFANACPNRG 189
            CGDP HFAN CPNRG
Sbjct: 901  CGDPSHFANVCPNRG 915


>ref|XP_017969682.1| PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Theobroma cacao]
          Length = 919

 Score = 1390 bits (3598), Expect = 0.0
 Identities = 675/918 (73%), Positives = 754/918 (82%), Gaps = 12/918 (1%)
 Frame = -2

Query: 2906 LRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHMSFTSV 2727
            ++ LNVAEKPSVAK+VSGILS+     GLRVRDGRSR+NRIFEFNY+++ Q  HM FTSV
Sbjct: 5    IKVLNVAEKPSVAKSVSGILSRNQ---GLRVRDGRSRFNRIFEFNYSVRGQPCHMLFTSV 61

Query: 2726 TGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLILWLDC 2547
            TGHLMEL+FEDR+RKWHSCDP DLYHAPV+K+VPEDK +I++TLEEEAR+CQWL+LWLDC
Sbjct: 62   TGHLMELEFEDRFRKWHSCDPADLYHAPVRKHVPEDKMDIKRTLEEEARRCQWLVLWLDC 121

Query: 2546 DREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFSDAVDARQE 2367
            DREGENIAFEV++VC   N +L I RAR SALI+REIH++ Q+LV PN  FSDAVDARQE
Sbjct: 122  DREGENIAFEVIDVCRAVNCHLTIRRARFSALIEREIHHATQNLVDPNPWFSDAVDARQE 181

Query: 2366 IDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEVQSHEPE 2187
            IDLRIGASFTRFQTM+LRD FV+D ATD+ N++LSYGPCQFPTLGF+VER+WEVQSHEPE
Sbjct: 182  IDLRIGASFTRFQTMMLRDKFVIDSATDDRNLVLSYGPCQFPTLGFVVERYWEVQSHEPE 241

Query: 2186 EFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEKLKYPPH 2007
            EFWTINC+H  +EG ATFNWMRGHLFD+TCA+I+YEMCVQEP ATVT VR QEKLKYPP+
Sbjct: 242  EFWTINCSHKLDEGVATFNWMRGHLFDHTCAVIVYEMCVQEPNATVTKVRHQEKLKYPPY 301

Query: 2006 PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTIVQEQQG 1827
            PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFS RTDLH IVQEQQ 
Sbjct: 302  PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSSRTDLHAIVQEQQD 361

Query: 1826 HPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKVYELVVR 1647
            HP WGSYAQRLLDP  SLWRNPS GGHDDKAHPPIHPTKFSAGE  WS DH K+YELVVR
Sbjct: 362  HPEWGSYAQRLLDPGTSLWRNPSSGGHDDKAHPPIHPTKFSAGEHNWSQDHRKLYELVVR 421

Query: 1646 HFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPTYNYGQQ 1467
            HFLACVSQPA+GAETTVEIDIA EQFS SGRVI+ +NYLDVYR+E+WGGSMIPTY  GQQ
Sbjct: 422  HFLACVSQPAVGAETTVEIDIADEQFSTSGRVILERNYLDVYRYESWGGSMIPTYTLGQQ 481

Query: 1466 FTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSSMRF 1287
            F P +LTLD GVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDS+ RF
Sbjct: 482  FIPASLTLDTGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSNTRF 541

Query: 1286 SPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQMKACFVD 1107
            SPTKLGEALVMGYDDMGYELWKP LR+MME DMK VS+G KRK EVL  CLQQMKACF+D
Sbjct: 542  SPTKLGEALVMGYDDMGYELWKPNLRSMMEFDMKEVSVGNKRKDEVLATCLQQMKACFLD 601

Query: 1106 ARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGNFMVGCL 927
            ARLNK KL EAMAVFFERSN++  ++ HA GEVVR+CGLC+ES MVL+K  DGNFMVGCL
Sbjct: 602  ARLNKVKLLEAMAVFFERSNQAAGDDNHAAGEVVRQCGLCRESSMVLKKNRDGNFMVGCL 661

Query: 926  GFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHLGCIGGC 747
            GFPQCRN +WLPGSV EA VT+NIC +C+PGPVYLIQFKFR+LEIPP +N NHLGCIGGC
Sbjct: 662  GFPQCRNAIWLPGSVLEAAVTSNICGSCNPGPVYLIQFKFRQLEIPPGFNANHLGCIGGC 721

Query: 746  DDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSSG---SYAN 576
            DDILRQL+E+CGTGSR  S+                          QTGHSS    S  +
Sbjct: 722  DDILRQLIEICGTGSR-MSARGRGPTTTSSNVQRNSSRQGACLYCQQTGHSSNDCPSQFS 780

Query: 575  APESSRGR-NSRSQEAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGCNFFVWED 399
               +SR R NS++   GE S+ CS+CG PC LRTANT  NRGRKFYSC +Q CNFF+WED
Sbjct: 781  GSRNSRSRTNSQNGMQGEPSVLCSTCGTPCVLRTANTANNRGRKFYSCPSQECNFFIWED 840

Query: 398  ---NASSGGTVPR----GSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPISG-R 243
               N + G ++PR    GS                           +F+SATG+PISG R
Sbjct: 841  EHNNGTGGRSIPRAGINGSASNSSRGGGRGRGRGRFGQNGARAADVTFVSATGDPISGRR 900

Query: 242  CFVCGDPGHFANACPNRG 189
            C+VCGDP HFAN CPNRG
Sbjct: 901  CYVCGDPSHFANVCPNRG 918


>ref|XP_021274352.1| DNA topoisomerase 3-alpha isoform X2 [Herrania umbratica]
          Length = 913

 Score = 1386 bits (3588), Expect = 0.0
 Identities = 669/912 (73%), Positives = 748/912 (82%), Gaps = 6/912 (0%)
 Frame = -2

Query: 2906 LRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHMSFTSV 2727
            ++ LNVAEKPSVAK+VSGILS+     GLRVRDGRSR+NRIFEFNY+++ Q  HM FTSV
Sbjct: 5    IKVLNVAEKPSVAKSVSGILSRNQ---GLRVRDGRSRFNRIFEFNYSVRGQPCHMLFTSV 61

Query: 2726 TGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLILWLDC 2547
            TGHLMEL+FEDR+RKWHSCDP DLYHAPV+K+VPEDK +I++TLEEEAR+CQWL+LWLDC
Sbjct: 62   TGHLMELEFEDRFRKWHSCDPADLYHAPVRKHVPEDKMDIKRTLEEEARRCQWLVLWLDC 121

Query: 2546 DREGENIAFEVVEVCTRANRNLNIWRARLSALIDREIHYSVQHLVRPNQLFSDAVDARQE 2367
            DREGENIAFEV++VC   N +L   RAR SALI+REIH+++Q+LV PNQ FSDAVDARQE
Sbjct: 122  DREGENIAFEVIDVCRAVNCHLTTRRARFSALIEREIHHAMQNLVDPNQWFSDAVDARQE 181

Query: 2366 IDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEVQSHEPE 2187
            IDLRIGASFTRFQTM+LRD FV+D ATD+ N++LSYGPCQFPTLGF+VER+WEVQSHEPE
Sbjct: 182  IDLRIGASFTRFQTMMLRDKFVIDSATDDRNLVLSYGPCQFPTLGFVVERYWEVQSHEPE 241

Query: 2186 EFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEKLKYPPH 2007
            EFWTINC+H  +EG ATFNWMRGHLFD+TC +IIYEMCVQEPTATVT VR QEK KYPP+
Sbjct: 242  EFWTINCSHKLDEGVATFNWMRGHLFDHTCVVIIYEMCVQEPTATVTAVRHQEKRKYPPY 301

Query: 2006 PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTIVQEQQG 1827
            PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFS RTDLH IVQEQQ 
Sbjct: 302  PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSSRTDLHAIVQEQQE 361

Query: 1826 HPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKVYELVVR 1647
            HP WGSYAQRLLDP  SLWRNPS GGHDDKAHPPIHPTKFS GE  WS DH K+Y+LVVR
Sbjct: 362  HPEWGSYAQRLLDPRTSLWRNPSSGGHDDKAHPPIHPTKFSTGEHNWSQDHRKLYDLVVR 421

Query: 1646 HFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPTYNYGQQ 1467
            HFLACVSQPA+GAETTVEIDIAGE FS SGRVI+ +NYLDVYR+E+WGGSMIPTY  GQQ
Sbjct: 422  HFLACVSQPAVGAETTVEIDIAGELFSTSGRVILERNYLDVYRYESWGGSMIPTYTLGQQ 481

Query: 1466 FTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSSMRF 1287
            F PT+LTLD GVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDS+ RF
Sbjct: 482  FIPTSLTLDTGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSNTRF 541

Query: 1286 SPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQMKACFVD 1107
            SPTKLGEALVMGYDDMG+ELWKP LR+MME DMK VS+G KRK EVL  CLQQMKACF+D
Sbjct: 542  SPTKLGEALVMGYDDMGHELWKPNLRSMMEFDMKEVSVGNKRKDEVLATCLQQMKACFLD 601

Query: 1106 ARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGNFMVGCL 927
            ARLNK KL EA+AVFFERSN++  ++ HA GEVVR+CGLC+ES MVL+K  DGNFMVGCL
Sbjct: 602  ARLNKVKLLEALAVFFERSNQAAGDDNHAAGEVVRQCGLCRESSMVLKKNRDGNFMVGCL 661

Query: 926  GFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHLGCIGGC 747
            GFPQCRN +WLPGSV EA VT+NIC +C+PGPVYLIQFKFR+LEIPP +N NHLGCIGGC
Sbjct: 662  GFPQCRNAIWLPGSVLEAAVTSNICGSCNPGPVYLIQFKFRQLEIPPGFNANHLGCIGGC 721

Query: 746  DDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSSGSYANAPE 567
            DD LRQL+E+CGTGSR  S+                          QTGH S    +   
Sbjct: 722  DDTLRQLIEICGTGSRM-SARGRGPTTTSSNVQRSSSRQGACLYCQQTGHFSNDCPSQFS 780

Query: 566  SSRGRNSRSQ-EAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGCNFFVWED--- 399
             SR   SR+  + GE S+PCS+CG PC LRTANT  NRGRKFYSC +Q CNFF+WED   
Sbjct: 781  GSRNSRSRTNSQNGEPSVPCSTCGTPCVLRTANTANNRGRKFYSCPSQDCNFFIWEDDHN 840

Query: 398  NASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXS-FMSATGEPISGR-CFVCGD 225
            N S G ++PR  I                            F+SATG+PISGR C+VCGD
Sbjct: 841  NGSGGRSIPRAGINGSASNSSRGGGGRGRFGQNGARAADVTFVSATGDPISGRRCYVCGD 900

Query: 224  PGHFANACPNRG 189
            P HFAN CPNRG
Sbjct: 901  PSHFANVCPNRG 912