BLASTX 2.2.26 [Sep-21-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Rehmannia29_contig00005609
         (3131 letters)

Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects 
           149,584,005 sequences; 54,822,741,787 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

ref|XP_011100133.1| DNA topoisomerase 3-alpha [Sesamum indicum]      1609   0.0  
ref|XP_012857604.1| PREDICTED: DNA topoisomerase 3-alpha [Erythr...  1591   0.0  
ref|XP_006341743.1| PREDICTED: DNA topoisomerase 3-alpha [Solanu...  1481   0.0  
ref|XP_015074855.1| PREDICTED: DNA topoisomerase 3-alpha isoform...  1476   0.0  
ref|XP_016547510.1| PREDICTED: DNA topoisomerase 3-alpha isoform...  1464   0.0  
ref|XP_009622049.1| PREDICTED: DNA topoisomerase 3-alpha isoform...  1461   0.0  
gb|PHT68423.1| DNA topoisomerase 3-alpha [Capsicum annuum]           1461   0.0  
ref|XP_010320982.1| PREDICTED: DNA topoisomerase 3-alpha isoform...  1459   0.0  
ref|XP_009622050.1| PREDICTED: DNA topoisomerase 3-alpha isoform...  1424   0.0  
ref|XP_010649354.1| PREDICTED: DNA topoisomerase 3-alpha isoform...  1420   0.0  
ref|XP_010649353.1| PREDICTED: DNA topoisomerase 3-alpha isoform...  1420   0.0  
gb|OVA03617.1| DNA topoisomerase [Macleaya cordata]                  1411   0.0  
ref|XP_023917748.1| DNA topoisomerase 3-alpha isoform X2 [Quercu...  1409   0.0  
ref|XP_023917747.1| DNA topoisomerase 3-alpha isoform X1 [Quercu...  1399   0.0  
ref|XP_010270299.1| PREDICTED: DNA topoisomerase 3-alpha [Nelumb...  1398   0.0  
gb|EOX92637.1| Topoisomerase 3alpha isoform 1 [Theobroma cacao]      1395   0.0  
ref|XP_024025914.1| DNA topoisomerase 3-alpha [Morus notabilis]      1394   0.0  
ref|XP_007048480.2| PREDICTED: DNA topoisomerase 3-alpha isoform...  1393   0.0  
ref|XP_017969682.1| PREDICTED: DNA topoisomerase 3-alpha isoform...  1392   0.0  
ref|XP_021274352.1| DNA topoisomerase 3-alpha isoform X2 [Herran...  1389   0.0  

>ref|XP_011100133.1| DNA topoisomerase 3-alpha [Sesamum indicum]
          Length = 906

 Score = 1609 bits (4166), Expect = 0.0
 Identities = 777/919 (84%), Positives = 824/919 (89%), Gaps = 4/919 (0%)
 Frame = -3

Query: 3096 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2917
            MAGGGGRPLRALNVAEKPSVAKAVSGIL++ PSSGGLRVR+GRSRYN+IFEFNY IQNQQ
Sbjct: 1    MAGGGGRPLRALNVAEKPSVAKAVSGILARNPSSGGLRVREGRSRYNKIFEFNYAIQNQQ 60

Query: 2916 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2737
             HM+FTSVTGHLME++FEDRYRKWHSCDPVDLYHAPVKK+VP DKS+IEKTLEEEARK Q
Sbjct: 61   FHMAFTSVTGHLMEVEFEDRYRKWHSCDPVDLYHAPVKKHVPHDKSDIEKTLEEEARKSQ 120

Query: 2736 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFS 2557
            WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHY+ QHL+RPNQLF+
Sbjct: 121  WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYAAQHLIRPNQLFA 180

Query: 2556 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFW 2377
            DAVD RQEIDLRIGASFTRFQTMLLRDAFVLDF TD+ NVILSYGPCQF          W
Sbjct: 181  DAVDVRQEIDLRIGASFTRFQTMLLRDAFVLDFTTDDKNVILSYGPCQF----------W 230

Query: 2376 EVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQ 2197
            E+QSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCA I+YEMCVQEPTATVTNVRQQ
Sbjct: 231  EIQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCATILYEMCVQEPTATVTNVRQQ 290

Query: 2196 EKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLH 2017
            EK KYPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQAGFISYPRTETDCFS RTDLH
Sbjct: 291  EKPKYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQAGFISYPRTETDCFSERTDLH 350

Query: 2016 TIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHH 1837
             IVQ+QQ HP+WGSYAQRLLDPE+ LWRNPSGGGHDDKAHPPIHPTKFS+GESGWS DHH
Sbjct: 351  RIVQDQQAHPIWGSYAQRLLDPESGLWRNPSGGGHDDKAHPPIHPTKFSSGESGWSQDHH 410

Query: 1836 KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMI 1657
            KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGS+I
Sbjct: 411  KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSVI 470

Query: 1656 PTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 1477
            PTY YGQQFTPTTLTLD+GVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA
Sbjct: 471  PTYTYGQQFTPTTLTLDSGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 530

Query: 1476 TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQ 1297
            TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRA MESDMKAVSMGTK KAEVLEACLQ
Sbjct: 531  TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAAMESDMKAVSMGTKSKAEVLEACLQ 590

Query: 1296 QMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPD 1117
            QMKACF+DARLNKGKLFEAMAVFFERSNRSN NE +AIG+V+R+CGLCQESDMVLR+KPD
Sbjct: 591  QMKACFLDARLNKGKLFEAMAVFFERSNRSNGNEPYAIGDVLRRCGLCQESDMVLRRKPD 650

Query: 1116 GNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVN 937
            GNFMVGCLG+PQCRNVVWLPGSVSEA VT+NICSTCSPGPVY+IQFKFRRLEIPPNYNV+
Sbjct: 651  GNFMVGCLGYPQCRNVVWLPGSVSEAAVTSNICSTCSPGPVYMIQFKFRRLEIPPNYNVD 710

Query: 936  HLGCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSS 757
            HLGCIGGCD+ LRQLVE+CGTGSRNNS++                       AW T HSS
Sbjct: 711  HLGCIGGCDNTLRQLVEICGTGSRNNSNM-PGRGQGHTQSSSSAQSNSRSQGAWHTAHSS 769

Query: 756  GSYANAPESSRGRNSRSQEA----GESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQG 589
             SY +  +SSRGR++++Q+A    GESSIPC+SCGAPCNLRTANTPANRGRKFYSCQAQG
Sbjct: 770  SSYTS--QSSRGRSAQTQDAAGEDGESSIPCASCGAPCNLRTANTPANRGRKFYSCQAQG 827

Query: 588  CNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPISGR 409
            CNFF+WEDNA+SGGTVPRGS                           +F+SATGEPISGR
Sbjct: 828  CNFFIWEDNANSGGTVPRGSTSRSASTSSRRGGRGRSNQSRGRANDVAFVSATGEPISGR 887

Query: 408  CFVCGDPGHFANACPNRGR 352
            CFVCGDP HFANACPNRGR
Sbjct: 888  CFVCGDPSHFANACPNRGR 906


>ref|XP_012857604.1| PREDICTED: DNA topoisomerase 3-alpha [Erythranthe guttata]
 gb|EYU20574.1| hypothetical protein MIMGU_mgv1a000984mg [Erythranthe guttata]
          Length = 923

 Score = 1591 bits (4119), Expect = 0.0
 Identities = 773/923 (83%), Positives = 814/923 (88%), Gaps = 8/923 (0%)
 Frame = -3

Query: 3096 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2917
            MAGGGGRPLRALNVAEKPSVAKAVSGILSK PSSGGLRVR+GRSRYN+IFEFNY IQNQQ
Sbjct: 1    MAGGGGRPLRALNVAEKPSVAKAVSGILSKNPSSGGLRVREGRSRYNKIFEFNYAIQNQQ 60

Query: 2916 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2737
              MSFTSVTGHLMEL+FEDRYRKWHSCDPVDLYHAPV+K+VP+DKS+IEKTLEEEARKCQ
Sbjct: 61   FQMSFTSVTGHLMELEFEDRYRKWHSCDPVDLYHAPVRKHVPQDKSDIEKTLEEEARKCQ 120

Query: 2736 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFS 2557
            WLILWLDCDREGENIAFEVVE C R NRNLNIWRARFSALIDREIH +VQHLVRPNQLF+
Sbjct: 121  WLILWLDCDREGENIAFEVVEACLRTNRNLNIWRARFSALIDREIHDAVQHLVRPNQLFA 180

Query: 2556 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFW 2377
            DAVD RQEIDLRIGASFTRFQTMLL+DAFVLDFAT+  NVILSYGPCQFPTLGF+VERFW
Sbjct: 181  DAVDVRQEIDLRIGASFTRFQTMLLKDAFVLDFATEERNVILSYGPCQFPTLGFVVERFW 240

Query: 2376 EVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQ 2197
            E+QSHEPEEFWTINCTHNSEEGTATF+WMRGHLFDYTCA IIYEMCV EP ATVTNVR Q
Sbjct: 241  EIQSHEPEEFWTINCTHNSEEGTATFSWMRGHLFDYTCATIIYEMCVLEPNATVTNVRNQ 300

Query: 2196 EKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLH 2017
            EK +YPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQAGFISYPRTETD FSVRTDLH
Sbjct: 301  EKPRYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQAGFISYPRTETDSFSVRTDLH 360

Query: 2016 TIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHH 1837
            TIVQEQQGHP WGSYAQRLLDPEA LWRNPS GGHDDKAHPPIHPTKFSAGESGWS DHH
Sbjct: 361  TIVQEQQGHPTWGSYAQRLLDPEAGLWRNPSSGGHDDKAHPPIHPTKFSAGESGWSQDHH 420

Query: 1836 KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMI 1657
            KVYELVVRHFLACVSQPAIGA TTV+IDIAGEQFSASG VI+AKNYLDVYRFETWGGSMI
Sbjct: 421  KVYELVVRHFLACVSQPAIGAVTTVDIDIAGEQFSASGTVILAKNYLDVYRFETWGGSMI 480

Query: 1656 PTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 1477
            PTYNYGQQFTPTTLTLD+GVTRPPPLLSEADLLSCMD AGIGTDATMHDHIKKLLDRFYA
Sbjct: 481  PTYNYGQQFTPTTLTLDSGVTRPPPLLSEADLLSCMDNAGIGTDATMHDHIKKLLDRFYA 540

Query: 1476 TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQ 1297
            TKDS+MRFSPTKLGEALV GYDDMGYELWKP LRAMMESDMKAVSMGTKRK+EVL++CLQ
Sbjct: 541  TKDSNMRFSPTKLGEALVKGYDDMGYELWKPNLRAMMESDMKAVSMGTKRKSEVLDSCLQ 600

Query: 1296 QMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPD 1117
            QMKACFVDARLNK KLFEAM VFFERSNR+N NEQ AIGEVVRKCGLCQESDMVLRKKPD
Sbjct: 601  QMKACFVDARLNKEKLFEAMDVFFERSNRANGNEQQAIGEVVRKCGLCQESDMVLRKKPD 660

Query: 1116 GNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVN 937
            GNFMVGCLG+PQCRNVVWLPGSVSEA VTT ICSTCSPGPVY+IQFKFRRLEIPPNYNV+
Sbjct: 661  GNFMVGCLGYPQCRNVVWLPGSVSEATVTTTICSTCSPGPVYMIQFKFRRLEIPPNYNVD 720

Query: 936  HLGCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHS- 760
            HLGCIGGCDD LRQLVE+CGTGSR  SSV                       AWQT  S 
Sbjct: 721  HLGCIGGCDDTLRQLVEICGTGSRTTSSVPGRGQGHTSSSSSAQQSNYRDQGAWQTASSA 780

Query: 759  --SGSYANAPESSRGRNSRSQEA-----GESSIPCSSCGAPCNLRTANTPANRGRKFYSC 601
              + S ++  +SSRGR++RSQ A     GESSIPC+SCGA CNLRTANT AN+GRKFYSC
Sbjct: 781  WQTASGSHPSQSSRGRSARSQRAGGAPDGESSIPCTSCGASCNLRTANTEANKGRKFYSC 840

Query: 600  QAQGCNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEP 421
            QAQGC+FFVWEDN +SGGT  RG                            +F+SATGEP
Sbjct: 841  QAQGCSFFVWEDNINSGGTAARGGGGRSASTTSRRGGRGRGSRGGGRTNDVAFVSATGEP 900

Query: 420  ISGRCFVCGDPGHFANACPNRGR 352
            ISGRCFVCG+PGHF+N CP RGR
Sbjct: 901  ISGRCFVCGEPGHFSNVCPCRGR 923


>ref|XP_006341743.1| PREDICTED: DNA topoisomerase 3-alpha [Solanum tuberosum]
          Length = 915

 Score = 1481 bits (3833), Expect = 0.0
 Identities = 713/920 (77%), Positives = 788/920 (85%), Gaps = 6/920 (0%)
 Frame = -3

Query: 3096 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2917
            MAGGGGR +R LNVAEKPSVAKAVSGILSK    GG+RVRDGRSRYN+IFEFNYTI+NQ 
Sbjct: 1    MAGGGGRVIRVLNVAEKPSVAKAVSGILSKN-QPGGMRVRDGRSRYNKIFEFNYTIRNQP 59

Query: 2916 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2737
              M FTSVTGHLMEL+F++RYRKWHSCDP+DLY+APV+K+VPEDK +I++TLE EAR CQ
Sbjct: 60   CQMLFTSVTGHLMELEFDERYRKWHSCDPLDLYNAPVRKFVPEDKLDIKRTLEAEARSCQ 119

Query: 2736 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFS 2557
            W++LWLDCDREGENIAFEV++VC +AN NLN+WRARFSALIDREIH SVQ LV+PNQLFS
Sbjct: 120  WIVLWLDCDREGENIAFEVLDVCRQANHNLNVWRARFSALIDREIHQSVQTLVQPNQLFS 179

Query: 2556 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFW 2377
            DAVD RQEIDLRIGASFTRFQTMLLR AFVLDFATD+ N++LSYGPCQFPTLGF+VER+W
Sbjct: 180  DAVDVRQEIDLRIGASFTRFQTMLLRGAFVLDFATDDRNIVLSYGPCQFPTLGFVVERYW 239

Query: 2376 EVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQ 2197
            E+Q+HEPEEFWTINCTHNS+EGTATFNWMRGHLFDYTC + IYEMC+QEP ATVT V+QQ
Sbjct: 240  EIQAHEPEEFWTINCTHNSDEGTATFNWMRGHLFDYTCGVTIYEMCIQEPIATVTKVKQQ 299

Query: 2196 EKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLH 2017
            EKLKYPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQ GFISYPRTETD FS +TDL 
Sbjct: 300  EKLKYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQNGFISYPRTETDSFSEKTDLR 359

Query: 2016 TIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHH 1837
            T+VQEQ+GHPVWG YAQRLLDP++ LWRNPSGGGHDDKAHPPIHPTKFSAGE+ WS DHH
Sbjct: 360  TMVQEQEGHPVWGIYAQRLLDPQSGLWRNPSGGGHDDKAHPPIHPTKFSAGETRWSQDHH 419

Query: 1836 KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMI 1657
            +VYELVVRHFLACVSQPA+GAET VEIDIAGE FSA GRVI+AKNYLDVYRFE+WGGS+I
Sbjct: 420  RVYELVVRHFLACVSQPAVGAETIVEIDIAGESFSACGRVILAKNYLDVYRFESWGGSVI 479

Query: 1656 PTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 1477
            PTY++GQQFTPTTLTLD+GVTRPPPLLSEADLL CMDKAGIGTDATMHDHIKKLLDRFYA
Sbjct: 480  PTYSFGQQFTPTTLTLDSGVTRPPPLLSEADLLGCMDKAGIGTDATMHDHIKKLLDRFYA 539

Query: 1476 TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQ 1297
             KDS+ RFSPTKLGEALVMGYDDMGYELWKPYLRAMME DMKAVS+GTKRKAEVLE CLQ
Sbjct: 540  IKDSNTRFSPTKLGEALVMGYDDMGYELWKPYLRAMMECDMKAVSIGTKRKAEVLETCLQ 599

Query: 1296 QMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPD 1117
            QMKACF DAR NKGKL EAMA+FFERSNRS+  EQ A+G+VVR+CGLC ESDMVLR+KPD
Sbjct: 600  QMKACFSDARTNKGKLLEAMAIFFERSNRSSGGEQQAVGDVVRRCGLCLESDMVLRQKPD 659

Query: 1116 GNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVN 937
            GNFMVGCLG+PQCRNVVWLPGSVSEA VT N C++CSPGPV+ IQFKFRRLEIPPNY+V 
Sbjct: 660  GNFMVGCLGYPQCRNVVWLPGSVSEASVTENTCTSCSPGPVFKIQFKFRRLEIPPNYSVQ 719

Query: 936  HLGCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAW----QT 769
            HLGCIGGCDDILRQLVE+CGTGSRNNS+                        +     QT
Sbjct: 720  HLGCIGGCDDILRQLVEICGTGSRNNSNTSGRGRGNPTASSSAQRGNSRAQSSCAYCRQT 779

Query: 768  GHSSGSYANAPESSRGRNSRSQEA--GESSIPCSSCGAPCNLRTANTPANRGRKFYSCQA 595
            GH S    +  ++SRGR +R+QE   GESSIPC+SCGAPC LRTANT  NRGRKF+SCQ+
Sbjct: 780  GHLSNDCPS--QASRGRTARAQEVDNGESSIPCNSCGAPCILRTANTANNRGRKFFSCQS 837

Query: 594  QGCNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPIS 415
            Q CNFFVWEDN  +GG   R +                           SF+SATGEPI+
Sbjct: 838  QECNFFVWEDNL-NGGRAERAN-TSASTSSGRGGRGRGRGQSGAHSSNVSFVSATGEPIT 895

Query: 414  GRCFVCGDPGHFANACPNRG 355
            GRCF+CGDPGHFAN CP RG
Sbjct: 896  GRCFICGDPGHFANVCPRRG 915


>ref|XP_015074855.1| PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Solanum pennellii]
          Length = 917

 Score = 1476 bits (3820), Expect = 0.0
 Identities = 709/920 (77%), Positives = 783/920 (85%), Gaps = 6/920 (0%)
 Frame = -3

Query: 3096 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2917
            MAGGGGR +R LNVAEKPSVAKAVSGILSK    GG+RVRDGRSRYN+IFEFNYTI+NQ 
Sbjct: 1    MAGGGGRVIRVLNVAEKPSVAKAVSGILSKN-QPGGIRVRDGRSRYNKIFEFNYTIRNQP 59

Query: 2916 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2737
              M FTSVTGHLME++F +RYRKWHSCDP+DLY+APV+K+VPEDK +I++TLE EAR CQ
Sbjct: 60   CQMLFTSVTGHLMEIEFHERYRKWHSCDPLDLYNAPVRKFVPEDKLDIKRTLEAEARSCQ 119

Query: 2736 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFS 2557
            W+ILWLDCDREGENIAFEV++VC +AN NL +WRARFSALIDREIH SVQ LV+PNQLFS
Sbjct: 120  WIILWLDCDREGENIAFEVLDVCRQANHNLTVWRARFSALIDREIHQSVQTLVQPNQLFS 179

Query: 2556 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFW 2377
            DAVD RQEIDLRIGASFTRFQTMLLR AFVLDFATD+ N++LSYGPCQFPTLGF+VER+W
Sbjct: 180  DAVDVRQEIDLRIGASFTRFQTMLLRGAFVLDFATDDRNLVLSYGPCQFPTLGFVVERYW 239

Query: 2376 EVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQ 2197
            E+Q+HEPEEFWTINCTHNS+EGTATFNWMRGHLFDYTC ++IYEMC+QEP ATVT V+QQ
Sbjct: 240  EIQAHEPEEFWTINCTHNSDEGTATFNWMRGHLFDYTCGVMIYEMCIQEPIATVTKVKQQ 299

Query: 2196 EKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLH 2017
            EKLKYPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQ GFISYPRTETDCFS +TDL 
Sbjct: 300  EKLKYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQNGFISYPRTETDCFSDKTDLR 359

Query: 2016 TIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHH 1837
            T+VQEQ+GHPVWG+YAQRLLDP++ LWRNPSGGGHDDKAHPPIHPTKFSAGE+ WS DHH
Sbjct: 360  TMVQEQEGHPVWGTYAQRLLDPQSGLWRNPSGGGHDDKAHPPIHPTKFSAGETRWSQDHH 419

Query: 1836 KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMI 1657
            +VYELVVRHFLACVSQPA+GAET VEIDIAGE FSA GRVI+AKNYLDVYRFE+WGGS+I
Sbjct: 420  RVYELVVRHFLACVSQPAVGAETIVEIDIAGESFSACGRVILAKNYLDVYRFESWGGSVI 479

Query: 1656 PTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 1477
            PTY++GQQFTPTTLTLD+GVTRPPPLLSEADLL CMDKAGIGTDATMHDHIKKLLDRFYA
Sbjct: 480  PTYSFGQQFTPTTLTLDSGVTRPPPLLSEADLLGCMDKAGIGTDATMHDHIKKLLDRFYA 539

Query: 1476 TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQ 1297
             KDS+ RFSPTKLGEALVMGYDDMGYELWKPYLRAMME DMKAVS GTKRKAEVLE CLQ
Sbjct: 540  IKDSNTRFSPTKLGEALVMGYDDMGYELWKPYLRAMMECDMKAVSTGTKRKAEVLETCLQ 599

Query: 1296 QMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPD 1117
            QMKACF DAR NKGKL EAMA+FFERSNRS+S EQ A+G VVR+CGLC ESDMVLR+KPD
Sbjct: 600  QMKACFSDARTNKGKLLEAMAIFFERSNRSSSGEQQAVGAVVRRCGLCLESDMVLRQKPD 659

Query: 1116 GNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVN 937
            GNFMVGCLG+PQCRNVVWLPGSVSEA VT N C TCSPGPV+ IQFKFR+ EIPP+Y+V 
Sbjct: 660  GNFMVGCLGYPQCRNVVWLPGSVSEASVTENTCITCSPGPVFKIQFKFRQQEIPPDYSVQ 719

Query: 936  HLGCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAW----QT 769
            HLGCIGGCDDILRQLVE+CGTGSRN+S+                        +     QT
Sbjct: 720  HLGCIGGCDDILRQLVEICGTGSRNSSNTSGRGRGNPTASSSAQRDNSRAQISCAYCRQT 779

Query: 768  GHSSGSYANAPESSRGRNSRSQEA--GESSIPCSSCGAPCNLRTANTPANRGRKFYSCQA 595
            GH S    +  ++SRGR +R+QE   GESSIPC+SCGAPC LRTANT  NRGRKF+SCQ+
Sbjct: 780  GHLSNDCPS--QASRGRTARAQEVDNGESSIPCNSCGAPCILRTANTANNRGRKFFSCQS 837

Query: 594  QGCNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPIS 415
              CNFFVWEDN S G      +                           SF+SATGEPI+
Sbjct: 838  SECNFFVWEDNLSGGRAERANTSASTSSGRGGRGRGRGCGQSGAHSSNVSFVSATGEPIT 897

Query: 414  GRCFVCGDPGHFANACPNRG 355
            GRCF+CGDPGHFAN CP RG
Sbjct: 898  GRCFICGDPGHFANVCPRRG 917


>ref|XP_016547510.1| PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Capsicum annuum]
          Length = 916

 Score = 1464 bits (3789), Expect = 0.0
 Identities = 706/920 (76%), Positives = 778/920 (84%), Gaps = 6/920 (0%)
 Frame = -3

Query: 3096 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2917
            MAGG GR +R LNVAEKPSVAKAVSGILSK    GG+RVRDGRSRYN+IFEFNYTI+NQ 
Sbjct: 1    MAGGRGRTIRVLNVAEKPSVAKAVSGILSKN-QPGGMRVRDGRSRYNKIFEFNYTIRNQP 59

Query: 2916 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2737
              M FTSVTGHLMEL+F+DRYRKWHSCDPVDLY+APV+KYVPEDK +I++TLE EAR CQ
Sbjct: 60   CQMLFTSVTGHLMELEFDDRYRKWHSCDPVDLYNAPVRKYVPEDKLDIKRTLEAEARSCQ 119

Query: 2736 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFS 2557
            W+ILWLDCDREGENIAFEV++VC +AN NLN+WRARFSALIDREIH SVQ LV+PNQLFS
Sbjct: 120  WIILWLDCDREGENIAFEVLDVCRQANNNLNVWRARFSALIDREIHQSVQTLVQPNQLFS 179

Query: 2556 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFW 2377
            DAVD RQEIDLRIGASFTRFQTMLLR+AFVLD A D+ NV+LSYGPCQFPTLGF+VER+W
Sbjct: 180  DAVDVRQEIDLRIGASFTRFQTMLLRNAFVLDVAMDDRNVVLSYGPCQFPTLGFVVERYW 239

Query: 2376 EVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQ 2197
            E+Q+HEPEEFWTINCTHNS+EG ATFNWMRGHLFDY+C +IIYEMC+QEPTATVT V+QQ
Sbjct: 240  EIQAHEPEEFWTINCTHNSDEGIATFNWMRGHLFDYSCGVIIYEMCIQEPTATVTKVKQQ 299

Query: 2196 EKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLH 2017
            EKLKYPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQ GFISYPRTETDCFS +TDL 
Sbjct: 300  EKLKYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQNGFISYPRTETDCFSEKTDLC 359

Query: 2016 TIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHH 1837
            T+VQEQ GHPVWGSYAQRLLDPE  LW+NPSGGGHDDKAHPPIHPTKFSAGES WS DHH
Sbjct: 360  TMVQEQGGHPVWGSYAQRLLDPELGLWKNPSGGGHDDKAHPPIHPTKFSAGESRWSQDHH 419

Query: 1836 KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMI 1657
            +VYELVVRHFLACVSQPA+GAET VEIDIAGE FSA GRVI+AKNYLDVYRFE+WGGS+I
Sbjct: 420  RVYELVVRHFLACVSQPAVGAETIVEIDIAGESFSACGRVILAKNYLDVYRFESWGGSVI 479

Query: 1656 PTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 1477
            PTY++GQQFTPTTLTLD+GVTRPPPLLSEADLL CMDKAGIGTDATMHDHIKKLLDRFYA
Sbjct: 480  PTYSFGQQFTPTTLTLDSGVTRPPPLLSEADLLGCMDKAGIGTDATMHDHIKKLLDRFYA 539

Query: 1476 TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQ 1297
             KDS+ RFSPTKLGEALVMGYDDMGYELWKPYLRAMME DMKAVS+GTKRKAEVLE CLQ
Sbjct: 540  IKDSNTRFSPTKLGEALVMGYDDMGYELWKPYLRAMMECDMKAVSIGTKRKAEVLETCLQ 599

Query: 1296 QMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPD 1117
            QMKACF+DAR N+GKLFEAMA+FFE SNRS+  E  A+G VVR+CGLC ESDMVLR+K D
Sbjct: 600  QMKACFLDARTNRGKLFEAMAIFFESSNRSSGGELQAVGGVVRRCGLCLESDMVLRQKSD 659

Query: 1116 GNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVN 937
            G+FMVGCLG+PQCRN VWLPGSVSEA VT N C++CSPGPV+ IQFKFRRLEIPPNY+V 
Sbjct: 660  GSFMVGCLGYPQCRNAVWLPGSVSEAFVTENTCTSCSPGPVFKIQFKFRRLEIPPNYSVQ 719

Query: 936  HLGCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSS 757
            HLGCIGGCDDILRQLVE+CGTGSR++S+                        +      +
Sbjct: 720  HLGCIGGCDDILRQLVEICGTGSRSSSNPLGRGRGNPTSSSSAQRGNSRAQSSCAYCRQA 779

Query: 756  GSYAN--APESSRGRNSRSQEA----GESSIPCSSCGAPCNLRTANTPANRGRKFYSCQA 595
            G  +N    + SRGR + SQE     GE SIPC+SCGAPC LRTANT  NRGRKF+SCQ+
Sbjct: 780  GHLSNDCPSQGSRGRTALSQEVDLQNGEPSIPCNSCGAPCILRTANTANNRGRKFFSCQS 839

Query: 594  QGCNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPIS 415
            QGCNFFVWEDN + G    R                             SF++ATGEPI+
Sbjct: 840  QGCNFFVWEDNLTRG----RAERANTSASTSSGRGGRGRGQGGAYPSSVSFVAATGEPIT 895

Query: 414  GRCFVCGDPGHFANACPNRG 355
            GRCF+CGDPGHFAN CP RG
Sbjct: 896  GRCFICGDPGHFANVCPRRG 915


>ref|XP_009622049.1| PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Nicotiana
            tomentosiformis]
 ref|XP_016447097.1| PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Nicotiana tabacum]
          Length = 913

 Score = 1461 bits (3782), Expect = 0.0
 Identities = 700/920 (76%), Positives = 778/920 (84%), Gaps = 8/920 (0%)
 Frame = -3

Query: 3090 GGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVH 2911
            GGGGR +R LNVAEKPSVAKAVSGILS+    GG+RVRDGRSRYN+IFEFNYTI+NQ   
Sbjct: 5    GGGGRVIRVLNVAEKPSVAKAVSGILSRN-QGGGMRVRDGRSRYNKIFEFNYTIRNQPCQ 63

Query: 2910 MSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWL 2731
            M FTSVTGHLMEL+F+DR+RKWHSCDP+ LY APV+KYVP+DK +I++TLEEEA +CQW+
Sbjct: 64   MLFTSVTGHLMELEFDDRFRKWHSCDPLHLYDAPVRKYVPQDKLDIKRTLEEEASRCQWI 123

Query: 2730 ILWLDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFSDA 2551
            ILWLDCDREGENIAFEV+EVC +AN NLN+WRARFSALIDREIH S Q LV+PNQLFSDA
Sbjct: 124  ILWLDCDREGENIAFEVLEVCRQANHNLNVWRARFSALIDREIHQSAQTLVQPNQLFSDA 183

Query: 2550 VDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEV 2371
            VD RQEIDLRIGASFTRFQTMLLRDAFVLDFATD+ N++LSYGPCQFPTLGF+VER+WE+
Sbjct: 184  VDVRQEIDLRIGASFTRFQTMLLRDAFVLDFATDDRNLVLSYGPCQFPTLGFVVERYWEI 243

Query: 2370 QSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEK 2191
            Q+HEPEEFWTINCTHN +EG+ATFNWMRGHLFDYTCA+ IYEMC+QEPTATV+ V+QQEK
Sbjct: 244  QAHEPEEFWTINCTHNFDEGSATFNWMRGHLFDYTCAVTIYEMCIQEPTATVSKVKQQEK 303

Query: 2190 LKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTI 2011
            LKYPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQ GFISYPRTETDCFS +TDL T+
Sbjct: 304  LKYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQNGFISYPRTETDCFSEKTDLRTM 363

Query: 2010 VQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKV 1831
            VQEQ GHPVWGSYAQRLLDP++ LWRNPSGGGHDDKAHPPIHPTKFSAGES WS DHH+V
Sbjct: 364  VQEQGGHPVWGSYAQRLLDPQSGLWRNPSGGGHDDKAHPPIHPTKFSAGESRWSQDHHRV 423

Query: 1830 YELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPT 1651
            YELVVRHFLACVS+PA+GAETTVEIDIAGE F A GRVI+AKNYLDVYRFE+WGGS+IPT
Sbjct: 424  YELVVRHFLACVSKPAVGAETTVEIDIAGESFFACGRVILAKNYLDVYRFESWGGSVIPT 483

Query: 1650 YNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATK 1471
            Y +GQQF PT+LTLD+GVTRPPPLLSEADLL CMDKAGIGTDATMHDHIKKLLDRFYA K
Sbjct: 484  YTFGQQFIPTSLTLDSGVTRPPPLLSEADLLGCMDKAGIGTDATMHDHIKKLLDRFYAIK 543

Query: 1470 DSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQM 1291
            DSS RFSPTKLGEALVMGYDDMGYELWKPYLRAMME DMKAVSMGTKRK EVLE CLQQM
Sbjct: 544  DSSTRFSPTKLGEALVMGYDDMGYELWKPYLRAMMECDMKAVSMGTKRKTEVLETCLQQM 603

Query: 1290 KACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGN 1111
            KACF+DAR NKGKLFEAMA+FFERSNRS+  EQ A+G+VVR+CGLC ESDMVLR+KPDGN
Sbjct: 604  KACFLDARANKGKLFEAMAIFFERSNRSSGGEQQAVGDVVRRCGLCLESDMVLRQKPDGN 663

Query: 1110 FMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHL 931
            FMVGCLG+PQCRNVVWLPGS+SEA VT N C++C PGPVY IQF+FRRLEIPPNY+  H+
Sbjct: 664  FMVGCLGYPQCRNVVWLPGSLSEASVTENTCTSCGPGPVYKIQFRFRRLEIPPNYSAQHI 723

Query: 930  GCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAW----QTGH 763
            GCIGGCDDILRQLVE+CGTGSR++S+                        +     QTGH
Sbjct: 724  GCIGGCDDILRQLVEICGTGSRSSSNTFGRGRGNPRASSSAQRGNSRAQGSCAYCRQTGH 783

Query: 762  SSGSYANAPESSRGRNSRSQEA----GESSIPCSSCGAPCNLRTANTPANRGRKFYSCQA 595
             S    +  ++SR R +RSQE     GE  IPC+SCG PCNLRTANT  NRGRKF+SCQ+
Sbjct: 784  LSNDCPS--QASRSRTARSQEVDLQNGEPLIPCNSCGEPCNLRTANTANNRGRKFFSCQS 841

Query: 594  QGCNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPIS 415
            + CNFFVWED  + G      +                           SF+SATGEPI+
Sbjct: 842  RECNFFVWEDTLNGGERTNTSA--------STSSRRGGRGQGGPNTSGVSFVSATGEPIT 893

Query: 414  GRCFVCGDPGHFANACPNRG 355
            GRCF+CGDPGHFAN CP RG
Sbjct: 894  GRCFICGDPGHFANVCPRRG 913


>gb|PHT68423.1| DNA topoisomerase 3-alpha [Capsicum annuum]
          Length = 916

 Score = 1461 bits (3781), Expect = 0.0
 Identities = 705/920 (76%), Positives = 777/920 (84%), Gaps = 6/920 (0%)
 Frame = -3

Query: 3096 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2917
            MAGG GR +R LNVAEKPSVAKAVSGILSK    GG+RVRDGRSRYN+IFEFNYTI+NQ 
Sbjct: 1    MAGGRGRTIRVLNVAEKPSVAKAVSGILSKN-QPGGMRVRDGRSRYNKIFEFNYTIRNQP 59

Query: 2916 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2737
              M FTSVTGHLMEL+F+DRYRKWHSCDPVDLY+APV+KYVPEDK +I++TLE EAR CQ
Sbjct: 60   CQMLFTSVTGHLMELEFDDRYRKWHSCDPVDLYNAPVRKYVPEDKLDIKRTLEAEARSCQ 119

Query: 2736 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFS 2557
            W+ILWLDCDREGENIAFEV++VC +AN NLN+WRARFSALIDREIH SVQ LV+PNQLFS
Sbjct: 120  WIILWLDCDREGENIAFEVLDVCRQANNNLNVWRARFSALIDREIHQSVQTLVQPNQLFS 179

Query: 2556 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFW 2377
            DAVD RQEIDLRIGASFTRFQTMLLR+AFVLD A D+ NV+LSYGPCQFPTLGF+VER+W
Sbjct: 180  DAVDVRQEIDLRIGASFTRFQTMLLRNAFVLDVAMDDRNVVLSYGPCQFPTLGFVVERYW 239

Query: 2376 EVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQ 2197
            E+Q+HEPEEFWTINCTHNS+EG ATFNWMRGHLFDY+C +IIYEMC+QEPTATVT V+QQ
Sbjct: 240  EIQAHEPEEFWTINCTHNSDEGIATFNWMRGHLFDYSCGVIIYEMCIQEPTATVTKVKQQ 299

Query: 2196 EKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLH 2017
            EKLKYPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQ GFISYPRTETDCFS +TDL 
Sbjct: 300  EKLKYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQNGFISYPRTETDCFSEKTDLC 359

Query: 2016 TIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHH 1837
            T+VQEQ GHPVWGSYAQRLLDPE  LW+NPSGGGHDDKAHPPIHPTKFSAGES WS DHH
Sbjct: 360  TMVQEQGGHPVWGSYAQRLLDPELGLWKNPSGGGHDDKAHPPIHPTKFSAGESRWSQDHH 419

Query: 1836 KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMI 1657
            +VYELVVRHFLACVSQPA+GAET VEIDIAGE FSA GRVI+AKNYLDVYRFE+WGGS+I
Sbjct: 420  RVYELVVRHFLACVSQPAVGAETIVEIDIAGESFSACGRVILAKNYLDVYRFESWGGSVI 479

Query: 1656 PTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 1477
            PTY++GQQFTPTTLTLD+GVTRPPPLLSEADLL CMDKAGIGTDATMHDHIKKLLDRFYA
Sbjct: 480  PTYSFGQQFTPTTLTLDSGVTRPPPLLSEADLLGCMDKAGIGTDATMHDHIKKLLDRFYA 539

Query: 1476 TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQ 1297
             KDS+ RFSPTKLGEALVMGYDDMGYELWKPYLRAMME DMKAVS+GTKRKAEVLE CLQ
Sbjct: 540  IKDSNTRFSPTKLGEALVMGYDDMGYELWKPYLRAMMECDMKAVSIGTKRKAEVLETCLQ 599

Query: 1296 QMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPD 1117
            QMKACF+DAR N+GKLFEAMA+FFE SNRS+  E  A+G VVR+CGLC ESDMVLR+K D
Sbjct: 600  QMKACFLDARTNRGKLFEAMAIFFESSNRSSGGELQAVGGVVRRCGLCLESDMVLRQKSD 659

Query: 1116 GNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVN 937
            G+FMVGCLG+PQCRN VWLPGSVSEA VT N C++CSPGPV+ IQFKFRRLEIPPNY+V 
Sbjct: 660  GSFMVGCLGYPQCRNAVWLPGSVSEAFVTENTCTSCSPGPVFKIQFKFRRLEIPPNYSVQ 719

Query: 936  HLGCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSS 757
            HLGCIGGCDDILRQLVE+CGTGSR++S+                        +      +
Sbjct: 720  HLGCIGGCDDILRQLVEICGTGSRSSSNPLGRGRGNPTSSSSAQRGNSRAQSSCAYCRQA 779

Query: 756  GSYAN--APESSRGRNSRSQEA----GESSIPCSSCGAPCNLRTANTPANRGRKFYSCQA 595
            G  +N    + S GR + SQE     GE SIPC+SCGAPC LRTANT  NRGRKF+SCQ+
Sbjct: 780  GHLSNDCPSQGSCGRTALSQEVDLQNGEPSIPCNSCGAPCILRTANTANNRGRKFFSCQS 839

Query: 594  QGCNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPIS 415
            QGCNFFVWEDN + G    R                             SF++ATGEPI+
Sbjct: 840  QGCNFFVWEDNLTRG----RAERANTSASTSSGRGGRGRGQGGAYPSSVSFVAATGEPIT 895

Query: 414  GRCFVCGDPGHFANACPNRG 355
            GRCF+CGDPGHFAN CP RG
Sbjct: 896  GRCFICGDPGHFANVCPRRG 915


>ref|XP_010320982.1| PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Solanum
            lycopersicum]
          Length = 915

 Score = 1459 bits (3778), Expect = 0.0
 Identities = 705/920 (76%), Positives = 781/920 (84%), Gaps = 6/920 (0%)
 Frame = -3

Query: 3096 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2917
            MAGGGGR +R LNVAEKPSVAKAVSGILSK    GG+RVRDGRSRYN+IFEFNYTI+NQ 
Sbjct: 1    MAGGGGRVIRVLNVAEKPSVAKAVSGILSKN-QPGGIRVRDGRSRYNKIFEFNYTIRNQP 59

Query: 2916 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2737
              M FTSVTGHLME++F +RYRKWHSCDP+DLY+AP++K+VPEDK +I++TLE EAR CQ
Sbjct: 60   CQMLFTSVTGHLMEIEFHERYRKWHSCDPLDLYNAPIRKFVPEDKLDIKRTLEAEARSCQ 119

Query: 2736 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFS 2557
            W+ILWLDCDREGENIAFEV++VC +AN NL +WRARFSALIDREIH SVQ LV+PNQLFS
Sbjct: 120  WIILWLDCDREGENIAFEVLDVCRQANHNLTVWRARFSALIDREIHQSVQTLVQPNQLFS 179

Query: 2556 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFW 2377
            DAVD RQEIDLRIGASFTRFQTMLLR AFVLDFATD+ N++LSYGPCQFPTLGF+VER+W
Sbjct: 180  DAVDVRQEIDLRIGASFTRFQTMLLRGAFVLDFATDDRNLVLSYGPCQFPTLGFVVERYW 239

Query: 2376 EVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQ 2197
            E+Q+HEPEEFWTINCTHNS+EGTATFNWMRGHLFDYTC ++IYEMC+QEP ATVT V+QQ
Sbjct: 240  EIQAHEPEEFWTINCTHNSDEGTATFNWMRGHLFDYTCGVMIYEMCIQEPIATVTKVKQQ 299

Query: 2196 EKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLH 2017
            EKLKYPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQ GFISYPRTETDCFS +TDL 
Sbjct: 300  EKLKYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQNGFISYPRTETDCFSDKTDLR 359

Query: 2016 TIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHH 1837
            T+VQEQ+GHPVWG+YAQRLLDP++ LWRNPSGGGHDDKAHPPIHPTKFSAGE+ WS DHH
Sbjct: 360  TMVQEQEGHPVWGTYAQRLLDPQSGLWRNPSGGGHDDKAHPPIHPTKFSAGETRWSQDHH 419

Query: 1836 KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMI 1657
            +VYELVVRHFLACVSQPA+GAET VEIDIAGE FSA GRVI+AKNYLDVYRFE+WGGS+I
Sbjct: 420  RVYELVVRHFLACVSQPAVGAETIVEIDIAGESFSACGRVILAKNYLDVYRFESWGGSVI 479

Query: 1656 PTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 1477
            PTY++GQQFTPTTLTLD+GV RPPPLLSEADLL CMDKAGIGTDATMHDHIKKLLDRFYA
Sbjct: 480  PTYSFGQQFTPTTLTLDSGVIRPPPLLSEADLLGCMDKAGIGTDATMHDHIKKLLDRFYA 539

Query: 1476 TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQ 1297
             KDS+ RFSPTKLGEALVMGYDDMGYELWKPYLRAMME DMKAVS GTKRKAEVLE CLQ
Sbjct: 540  IKDSNTRFSPTKLGEALVMGYDDMGYELWKPYLRAMMECDMKAVSTGTKRKAEVLETCLQ 599

Query: 1296 QMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPD 1117
            QMKACF DAR NK KL EAMA+FFERSNRS+S EQ A+G VVR+CGLC ESDMVLR+KPD
Sbjct: 600  QMKACFSDARTNKEKLLEAMAIFFERSNRSSSGEQQAVGAVVRRCGLCLESDMVLRQKPD 659

Query: 1116 GNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVN 937
            GNFMVGCLG+PQCRNVVWLPGSVSEA VT N C TCSPGPV+ IQFKFR+ EIPP+Y+V 
Sbjct: 660  GNFMVGCLGYPQCRNVVWLPGSVSEASVTENTCITCSPGPVFKIQFKFRQQEIPPDYSVQ 719

Query: 936  HLGCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAW----QT 769
            HLGCIGGCDDILRQLVE+CGTGSRN+S+                        +     QT
Sbjct: 720  HLGCIGGCDDILRQLVEICGTGSRNSSNPSGRGRGNPTAFSSAQRDNSRAQSSCAYCRQT 779

Query: 768  GHSSGSYANAPESSRGRNSRSQEA--GESSIPCSSCGAPCNLRTANTPANRGRKFYSCQA 595
            GH S    +  ++SR R +R+QE   GESS+PC+SCGAPC LRTANT  NRGRKF+SCQ+
Sbjct: 780  GHLSNDCPS--QASRDRTARAQEVDNGESSMPCNSCGAPCILRTANTANNRGRKFFSCQS 837

Query: 594  QGCNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPIS 415
              CNFFVWEDN  SGG   R +                           SF+SATGEPI+
Sbjct: 838  SECNFFVWEDNL-SGGRAERAN-TSASTSSGRGGRGRGRGQSGAHSSNVSFVSATGEPIT 895

Query: 414  GRCFVCGDPGHFANACPNRG 355
             RCF+CGDPGHFAN CP RG
Sbjct: 896  VRCFICGDPGHFANVCPRRG 915


>ref|XP_009622050.1| PREDICTED: DNA topoisomerase 3-alpha isoform X2 [Nicotiana
            tomentosiformis]
          Length = 900

 Score = 1424 bits (3685), Expect = 0.0
 Identities = 688/920 (74%), Positives = 765/920 (83%), Gaps = 8/920 (0%)
 Frame = -3

Query: 3090 GGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVH 2911
            GGGGR +R LNVAEKPSVAKAVSGILS+    GG+RVRDGRSRYN+IFEFNYTI+NQ   
Sbjct: 5    GGGGRVIRVLNVAEKPSVAKAVSGILSRN-QGGGMRVRDGRSRYNKIFEFNYTIRNQPCQ 63

Query: 2910 MSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWL 2731
            M FTSVTGHLMEL+F+DR+RKWHSCDP+ LY APV+KYVP+DK +I++TLEEEA +CQW+
Sbjct: 64   MLFTSVTGHLMELEFDDRFRKWHSCDPLHLYDAPVRKYVPQDKLDIKRTLEEEASRCQWI 123

Query: 2730 ILWLDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFSDA 2551
            ILWLDCDREGENIAFEV+EVC +AN NLN+WRARFSALIDREIH S Q LV+PNQLFSDA
Sbjct: 124  ILWLDCDREGENIAFEVLEVCRQANHNLNVWRARFSALIDREIHQSAQTLVQPNQLFSDA 183

Query: 2550 VDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEV 2371
            VD RQEIDLRIGASFTRFQTMLLRDAFVLDFATD+ N++LSYGPCQFPTLGF+VER+WE+
Sbjct: 184  VDVRQEIDLRIGASFTRFQTMLLRDAFVLDFATDDRNLVLSYGPCQFPTLGFVVERYWEI 243

Query: 2370 QSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEK 2191
            Q+HEPEEFWTINCTHN +EG+ATFNWMRGHLFDYTCA+ IYEMC+QEPTATV+ V+QQEK
Sbjct: 244  QAHEPEEFWTINCTHNFDEGSATFNWMRGHLFDYTCAVTIYEMCIQEPTATVSKVKQQEK 303

Query: 2190 LKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTI 2011
            LKYPPHPLSTIELEKRASRYFRMSSE TMKVAEDLYQ GFISYPRTETDCFS +TDL T+
Sbjct: 304  LKYPPHPLSTIELEKRASRYFRMSSEQTMKVAEDLYQNGFISYPRTETDCFSEKTDLRTM 363

Query: 2010 VQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKV 1831
            VQEQ GHPVWGSYAQRLLDP++ LWRNPSGGGHDDKAHPPIHPTKFSAGES WS DHH+V
Sbjct: 364  VQEQGGHPVWGSYAQRLLDPQSGLWRNPSGGGHDDKAHPPIHPTKFSAGESRWSQDHHRV 423

Query: 1830 YELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPT 1651
            YELVVRHFLACVS+PA+GAETTVEIDIAGE F A GRVI+AKNYLDVYRFE+WGGS+IPT
Sbjct: 424  YELVVRHFLACVSKPAVGAETTVEIDIAGESFFACGRVILAKNYLDVYRFESWGGSVIPT 483

Query: 1650 YNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATK 1471
            Y +GQQF PT+LTLD+GVTRPPPLLSEADLL CMDKAGIGTDATMHDHIKKLLDRFYA K
Sbjct: 484  YTFGQQFIPTSLTLDSGVTRPPPLLSEADLLGCMDKAGIGTDATMHDHIKKLLDRFYAIK 543

Query: 1470 DSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQM 1291
            DSS RFSPTKLGEALVMGYDDMGYELWKPYLRAMME DMKAVSMGTKRK EVLE CLQQM
Sbjct: 544  DSSTRFSPTKLGEALVMGYDDMGYELWKPYLRAMMECDMKAVSMGTKRKTEVLETCLQQM 603

Query: 1290 KACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGN 1111
            KACF+DAR NKGKLFEAMA+FFERSNRS+  EQ A+G+VVR+CGLC ESDMVLR+KP   
Sbjct: 604  KACFLDARANKGKLFEAMAIFFERSNRSSGGEQQAVGDVVRRCGLCLESDMVLRQKP--- 660

Query: 1110 FMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHL 931
                      CRNVVWLPGS+SEA VT N C++C PGPVY IQF+FRRLEIPPNY+  H+
Sbjct: 661  ----------CRNVVWLPGSLSEASVTENTCTSCGPGPVYKIQFRFRRLEIPPNYSAQHI 710

Query: 930  GCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAW----QTGH 763
            GCIGGCDDILRQLVE+CGTGSR++S+                        +     QTGH
Sbjct: 711  GCIGGCDDILRQLVEICGTGSRSSSNTFGRGRGNPRASSSAQRGNSRAQGSCAYCRQTGH 770

Query: 762  SSGSYANAPESSRGRNSRSQEA----GESSIPCSSCGAPCNLRTANTPANRGRKFYSCQA 595
             S    +  ++SR R +RSQE     GE  IPC+SCG PCNLRTANT  NRGRKF+SCQ+
Sbjct: 771  LSNDCPS--QASRSRTARSQEVDLQNGEPLIPCNSCGEPCNLRTANTANNRGRKFFSCQS 828

Query: 594  QGCNFFVWEDNASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPIS 415
            + CNFFVWED  + G      +                           SF+SATGEPI+
Sbjct: 829  RECNFFVWEDTLNGGERTNTSA--------STSSRRGGRGQGGPNTSGVSFVSATGEPIT 880

Query: 414  GRCFVCGDPGHFANACPNRG 355
            GRCF+CGDPGHFAN CP RG
Sbjct: 881  GRCFICGDPGHFANVCPRRG 900


>ref|XP_010649354.1| PREDICTED: DNA topoisomerase 3-alpha isoform X2 [Vitis vinifera]
          Length = 918

 Score = 1420 bits (3675), Expect = 0.0
 Identities = 686/920 (74%), Positives = 767/920 (83%), Gaps = 14/920 (1%)
 Frame = -3

Query: 3072 LRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHMSFTSV 2893
            ++ LNVAEKPSVAKAV+ ILS+     GLRVR+GRSRYN++FEFNY+I+ Q   M  TSV
Sbjct: 1    MKVLNVAEKPSVAKAVATILSRNQ---GLRVREGRSRYNKLFEFNYSIRGQHCQMVVTSV 57

Query: 2892 TGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLILWLDC 2713
             GHLMEL+FEDR+RKWHSCDP  LYHAPV+K+VPEDK +I++TLEEEARKCQWL+LWLDC
Sbjct: 58   IGHLMELEFEDRFRKWHSCDPAHLYHAPVRKFVPEDKLDIKRTLEEEARKCQWLVLWLDC 117

Query: 2712 DREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFSDAVDARQE 2533
            DREGENIAFEV+EVC + NR++++WRARFSALIDREIH SVQ+LVRPNQLF+DAVD RQE
Sbjct: 118  DREGENIAFEVLEVCAQVNRHIDVWRARFSALIDREIHESVQNLVRPNQLFADAVDVRQE 177

Query: 2532 IDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEVQSHEPE 2353
            IDLRIGASFTRFQTMLLRDAFVLDFA D+ N++LSYGPCQFPTLGF+VER+WE+QSHEPE
Sbjct: 178  IDLRIGASFTRFQTMLLRDAFVLDFAADDRNLVLSYGPCQFPTLGFVVERYWEIQSHEPE 237

Query: 2352 EFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEKLKYPPH 2173
            EFWTINC+H S+EGT+TFNWMR HLFDYTCA+IIYEMC+QEPTATVT VRQQEKLKYPPH
Sbjct: 238  EFWTINCSHKSDEGTSTFNWMRAHLFDYTCAVIIYEMCIQEPTATVTKVRQQEKLKYPPH 297

Query: 2172 PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTIVQEQQG 1993
            PL+TIELEKRASRYF MSSEHTMKVAEDLYQ GFISYPRTETD FS RTDLH IVQEQ G
Sbjct: 298  PLNTIELEKRASRYFHMSSEHTMKVAEDLYQTGFISYPRTETDYFSERTDLHGIVQEQLG 357

Query: 1992 HPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKVYELVVR 1813
            HP+WGSYAQRLLDP A LWRNPS GGHDDKAHPPIHPTKFSAGESGWS DH ++YELVVR
Sbjct: 358  HPIWGSYAQRLLDPGAGLWRNPSNGGHDDKAHPPIHPTKFSAGESGWSQDHQRLYELVVR 417

Query: 1812 HFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPTYNYGQQ 1633
            HFLACVSQPA+GAET VEIDIAGE FS+SGRVIIAKNYLDVYRFE+WGGSMIPTY +GQQ
Sbjct: 418  HFLACVSQPAVGAETIVEIDIAGESFSSSGRVIIAKNYLDVYRFESWGGSMIPTYVFGQQ 477

Query: 1632 FTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSSMRF 1453
            F PTTLTLD+GVTRPPPLLSEADLL+CMDKAGIGTDATMHDHIKKLLDRFYATKDS+ RF
Sbjct: 478  FIPTTLTLDSGVTRPPPLLSEADLLNCMDKAGIGTDATMHDHIKKLLDRFYATKDSNTRF 537

Query: 1452 SPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQMKACFVD 1273
            SPT LGEALVMGYDDMGYELWKPYLR+MME DMKAVS+GTKR+ EVL  CL+QMKACF+D
Sbjct: 538  SPTNLGEALVMGYDDMGYELWKPYLRSMMECDMKAVSIGTKRRNEVLTTCLEQMKACFLD 597

Query: 1272 ARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGNFMVGCL 1093
            ARLNK KL EAMA+FFERSNRS+ +EQH +G+VVR+C LCQESDMVLR+KPDGNFMVGCL
Sbjct: 598  ARLNKVKLLEAMALFFERSNRSSGDEQHEVGDVVRQCTLCQESDMVLRRKPDGNFMVGCL 657

Query: 1092 GFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHLGCIGGC 913
            G+PQCRNVVWLPGS+SEA +TT  C+ C+PGPVY IQFKFRRLEIPPNYN++HLGC+ GC
Sbjct: 658  GYPQCRNVVWLPGSISEAAITTISCNHCTPGPVYKIQFKFRRLEIPPNYNIDHLGCVCGC 717

Query: 912  DDILRQLVEVCGTGSRNNSSV---XXXXXXXXXXXXXXXXXXXXXXXAWQTGHSSGSYAN 742
            D+ILRQL E+CGTGSR  S+V                            QTGHSS    +
Sbjct: 718  DEILRQLTEICGTGSRICSTVPARGRGSNASSTNAQRSNTRQTACIHCSQTGHSSNDCPS 777

Query: 741  APESSRGRNSR--SQEAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGCNFFVWE 568
                SR   S   +  +GESSIPC+ CG PC LRTANT  NRGRKFYSCQ+Q CNFFVWE
Sbjct: 778  RVPRSRNSQSHRTNMPSGESSIPCNVCGTPCILRTANTENNRGRKFYSCQSQECNFFVWE 837

Query: 567  D--NASSGG------TVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPISG 412
            D  N+SSGG      T    +                           +F+SATG+P+SG
Sbjct: 838  DSLNSSSGGRSAQPATARSSASNPSRRGGRGRGDRGRGRQSGARTSDTTFVSATGDPVSG 897

Query: 411  -RCFVCGDPGHFANACPNRG 355
             RCFVCGDP HFAN CPNRG
Sbjct: 898  RRCFVCGDPSHFANVCPNRG 917


>ref|XP_010649353.1| PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Vitis vinifera]
          Length = 919

 Score = 1420 bits (3675), Expect = 0.0
 Identities = 687/921 (74%), Positives = 768/921 (83%), Gaps = 15/921 (1%)
 Frame = -3

Query: 3072 LRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHMSFTSV 2893
            ++ LNVAEKPSVAKAV+ ILS+     GLRVR+GRSRYN++FEFNY+I+ Q   M  TSV
Sbjct: 1    MKVLNVAEKPSVAKAVATILSRNQ---GLRVREGRSRYNKLFEFNYSIRGQHCQMVVTSV 57

Query: 2892 TGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLILWLDC 2713
             GHLMEL+FEDR+RKWHSCDP  LYHAPV+K+VPEDK +I++TLEEEARKCQWL+LWLDC
Sbjct: 58   IGHLMELEFEDRFRKWHSCDPAHLYHAPVRKFVPEDKLDIKRTLEEEARKCQWLVLWLDC 117

Query: 2712 DREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFSDAVDARQE 2533
            DREGENIAFEV+EVC + NR++++WRARFSALIDREIH SVQ+LVRPNQLF+DAVD RQE
Sbjct: 118  DREGENIAFEVLEVCAQVNRHIDVWRARFSALIDREIHESVQNLVRPNQLFADAVDVRQE 177

Query: 2532 IDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEVQSHEPE 2353
            IDLRIGASFTRFQTMLLRDAFVLDFA D+ N++LSYGPCQFPTLGF+VER+WE+QSHEPE
Sbjct: 178  IDLRIGASFTRFQTMLLRDAFVLDFAADDRNLVLSYGPCQFPTLGFVVERYWEIQSHEPE 237

Query: 2352 EFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEKLKYPPH 2173
            EFWTINC+H S+EGT+TFNWMR HLFDYTCA+IIYEMC+QEPTATVT VRQQEKLKYPPH
Sbjct: 238  EFWTINCSHKSDEGTSTFNWMRAHLFDYTCAVIIYEMCIQEPTATVTKVRQQEKLKYPPH 297

Query: 2172 PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTIVQEQQG 1993
            PL+TIELEKRASRYF MSSEHTMKVAEDLYQ GFISYPRTETD FS RTDLH IVQEQ G
Sbjct: 298  PLNTIELEKRASRYFHMSSEHTMKVAEDLYQTGFISYPRTETDYFSERTDLHGIVQEQLG 357

Query: 1992 HPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKVYELVVR 1813
            HP+WGSYAQRLLDP A LWRNPS GGHDDKAHPPIHPTKFSAGESGWS DH ++YELVVR
Sbjct: 358  HPIWGSYAQRLLDPGAGLWRNPSNGGHDDKAHPPIHPTKFSAGESGWSQDHQRLYELVVR 417

Query: 1812 HFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPTYNYGQQ 1633
            HFLACVSQPA+GAET VEIDIAGE FS+SGRVIIAKNYLDVYRFE+WGGSMIPTY +GQQ
Sbjct: 418  HFLACVSQPAVGAETIVEIDIAGESFSSSGRVIIAKNYLDVYRFESWGGSMIPTYVFGQQ 477

Query: 1632 FTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSSMRF 1453
            F PTTLTLD+GVTRPPPLLSEADLL+CMDKAGIGTDATMHDHIKKLLDRFYATKDS+ RF
Sbjct: 478  FIPTTLTLDSGVTRPPPLLSEADLLNCMDKAGIGTDATMHDHIKKLLDRFYATKDSNTRF 537

Query: 1452 SPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQMKACFVD 1273
            SPT LGEALVMGYDDMGYELWKPYLR+MME DMKAVS+GTKR+ EVL  CL+QMKACF+D
Sbjct: 538  SPTNLGEALVMGYDDMGYELWKPYLRSMMECDMKAVSIGTKRRNEVLTTCLEQMKACFLD 597

Query: 1272 ARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGNFMVGCL 1093
            ARLNK KL EAMA+FFERSNRS+ +EQH +G+VVR+C LCQESDMVLR+KPDGNFMVGCL
Sbjct: 598  ARLNKVKLLEAMALFFERSNRSSGDEQHEVGDVVRQCTLCQESDMVLRRKPDGNFMVGCL 657

Query: 1092 GFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHLGCIGGC 913
            G+PQCRNVVWLPGS+SEA +TT  C+ C+PGPVY IQFKFRRLEIPPNYN++HLGC+ GC
Sbjct: 658  GYPQCRNVVWLPGSISEAAITTISCNHCTPGPVYKIQFKFRRLEIPPNYNIDHLGCVCGC 717

Query: 912  DDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAW----QTGHSSGSYA 745
            D+ILRQL E+CGTGSR  S+V                       A     QTGHSS    
Sbjct: 718  DEILRQLTEICGTGSRICSTVPAARGRGSNASSTNAQRSNTRQTACIHCSQTGHSSNDCP 777

Query: 744  NAPESSRGRNSR--SQEAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGCNFFVW 571
            +    SR   S   +  +GESSIPC+ CG PC LRTANT  NRGRKFYSCQ+Q CNFFVW
Sbjct: 778  SRVPRSRNSQSHRTNMPSGESSIPCNVCGTPCILRTANTENNRGRKFYSCQSQECNFFVW 837

Query: 570  ED--NASSGG------TVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPIS 415
            ED  N+SSGG      T    +                           +F+SATG+P+S
Sbjct: 838  EDSLNSSSGGRSAQPATARSSASNPSRRGGRGRGDRGRGRQSGARTSDTTFVSATGDPVS 897

Query: 414  G-RCFVCGDPGHFANACPNRG 355
            G RCFVCGDP HFAN CPNRG
Sbjct: 898  GRRCFVCGDPSHFANVCPNRG 918


>gb|OVA03617.1| DNA topoisomerase [Macleaya cordata]
          Length = 936

 Score = 1411 bits (3652), Expect = 0.0
 Identities = 685/935 (73%), Positives = 777/935 (83%), Gaps = 24/935 (2%)
 Frame = -3

Query: 3087 GGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHM 2908
            GGGR +R LNVAEKPSVAKAVSGILS+     GLRVR+GRSRYN+IFEF YTI+ Q  +M
Sbjct: 3    GGGRTIRVLNVAEKPSVAKAVSGILSRNQ---GLRVREGRSRYNKIFEFEYTIRGQPCNM 59

Query: 2907 SFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLI 2728
            + TSVTGHLMEL+FEDRYRKW+SCDPVDLY A V+K VP+DK +I++TLEEEAR+CQWL+
Sbjct: 60   AVTSVTGHLMELEFEDRYRKWNSCDPVDLYQAVVRKLVPQDKLDIKRTLEEEARRCQWLV 119

Query: 2727 LWLDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFSDAV 2548
            LWLDCDREGENIAFEV+EVCT  N NLNIWRARFSALI+R+IH SVQ+LVRPNQLF+DAV
Sbjct: 120  LWLDCDREGENIAFEVIEVCTAVNPNLNIWRARFSALIERDIHESVQNLVRPNQLFADAV 179

Query: 2547 DARQEIDLRIGASFTRFQTMLLRDAFVLDFA-TDNTNVILSYGPCQFPTLGFIVERFWEV 2371
            DARQEIDLRIGASFTRFQTMLL+DAFVLD +  D  N++LSYGPCQFPTLGFIVER+WE+
Sbjct: 180  DARQEIDLRIGASFTRFQTMLLKDAFVLDGSGNDVRNMVLSYGPCQFPTLGFIVERYWEI 239

Query: 2370 QSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEK 2191
            Q+HEPEEFWTINCTH SE+GTATFNWMRGH+FDY+CA+IIYEMCVQEPTATVT VR Q+K
Sbjct: 240  QAHEPEEFWTINCTHTSEDGTATFNWMRGHMFDYSCAVIIYEMCVQEPTATVTKVRDQQK 299

Query: 2190 LKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTI 2011
            LK PP+PL+TIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETD FS RTDLH I
Sbjct: 300  LKQPPYPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDSFSERTDLHAI 359

Query: 2010 VQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKV 1831
            VQEQQGHPVWGSYAQ+LLDP A LWRNPS GGHDDKAHPPIHPTKFSAGESGWS DH++V
Sbjct: 360  VQEQQGHPVWGSYAQQLLDPGAGLWRNPSNGGHDDKAHPPIHPTKFSAGESGWSQDHNRV 419

Query: 1830 YELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPT 1651
            YELVVRHFLACVSQPA+GAETTVEIDIAGE FS SGR+IIA+NYLDVYRFE+WGGS+IP 
Sbjct: 420  YELVVRHFLACVSQPAVGAETTVEIDIAGELFSVSGRMIIARNYLDVYRFESWGGSVIPK 479

Query: 1650 YNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATK 1471
            Y +GQQFTPTTLTLD+GVTRPPPLLSEADLL+CMDKAGIGTDATMHDHIKKLLDRFYATK
Sbjct: 480  YLFGQQFTPTTLTLDSGVTRPPPLLSEADLLTCMDKAGIGTDATMHDHIKKLLDRFYATK 539

Query: 1470 DSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQM 1291
            D++ RFSPT LGEALVMGYDDMGY+LWKPYLR+MME DMKAVS+GTKRK+EVLE CLQQM
Sbjct: 540  DANTRFSPTNLGEALVMGYDDMGYKLWKPYLRSMMECDMKAVSLGTKRKSEVLETCLQQM 599

Query: 1290 KACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGN 1111
            KACF+DARL K KL EAMA+FF+RSNRS+ +EQH  GEVVR+C +CQESDMVL++KPDGN
Sbjct: 600  KACFLDARLQKVKLLEAMAIFFDRSNRSSGDEQHVGGEVVRQCAVCQESDMVLKRKPDGN 659

Query: 1110 FMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHL 931
            FMVGCLG+PQCRNVVWLP S+SEA VTT +C++C+PGPV++IQFKFR++EIPPNYNVNHL
Sbjct: 660  FMVGCLGYPQCRNVVWLPASISEATVTTQVCNSCNPGPVFMIQFKFRQMEIPPNYNVNHL 719

Query: 930  GCIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAW---QTGHS 760
            GCIGGCD+ LRQL E+CGTGSR++SS+                            QTGHS
Sbjct: 720  GCIGGCDETLRQLREICGTGSRSSSSIPARGHGPTASSNTTQRPSTRQGTCTHCRQTGHS 779

Query: 759  SGSYANAPESSRGRNSRSQ--EAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGC 586
            S    +    S+   SR++  ++GE S+ C++CGA C LR ANT  NRGRKFYSCQ++ C
Sbjct: 780  SNDCPSQTLHSQSVQSRARNFQSGEPSVMCTTCGAACPLREANTTNNRGRKFYSCQSRDC 839

Query: 585  NFFVWEDN-----------------ASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXX 457
            NFFVW DN                 ++S     RGS                        
Sbjct: 840  NFFVWADNVNSSTGAEDMSSSRPATSNSSSGARRGSRGRGRSSGRGGGRSSRAAAGRAST 899

Query: 456  XXXSFMSATGEPISGR-CFVCGDPGHFANACPNRG 355
               +F+SATGEPISGR CFVCGDP HFAN CP+RG
Sbjct: 900  TGGTFVSATGEPISGRRCFVCGDPSHFANNCPSRG 934


>ref|XP_023917748.1| DNA topoisomerase 3-alpha isoform X2 [Quercus suber]
 gb|POF03697.1| dna topoisomerase 3-alpha [Quercus suber]
          Length = 924

 Score = 1409 bits (3646), Expect = 0.0
 Identities = 681/925 (73%), Positives = 763/925 (82%), Gaps = 11/925 (1%)
 Frame = -3

Query: 3096 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2917
            M+GGG   ++ L+VAEKPSVAK+V+ ILS+  ++GGLR R+GRSRYN+IFEF+Y+I  + 
Sbjct: 1    MSGGGRGGMKVLHVAEKPSVAKSVATILSR--NNGGLRTREGRSRYNKIFEFSYSINGRP 58

Query: 2916 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2737
             HM  TSVTGHLMEL+F+DRYRKWHSCDP DL+HAPV K+VPEDK +I++TLEEEAR CQ
Sbjct: 59   CHMLVTSVTGHLMELEFQDRYRKWHSCDPADLFHAPVHKFVPEDKLDIKRTLEEEARWCQ 118

Query: 2736 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFS 2557
            WL+LWLDCDREGENIAFEV+EVCT  N +L I RA FSALIDREIH +VQ LV PN+ F+
Sbjct: 119  WLVLWLDCDREGENIAFEVIEVCTAVNPHLTIKRAHFSALIDREIHEAVQCLVEPNKCFA 178

Query: 2556 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFW 2377
            DAVDARQEIDLRIGASFTRFQTMLLRDAFV+DF TD+ N++LSYGPCQFPTLGF+VER+W
Sbjct: 179  DAVDARQEIDLRIGASFTRFQTMLLRDAFVIDFTTDDRNLVLSYGPCQFPTLGFVVERYW 238

Query: 2376 EVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQ 2197
            E+Q+HEPEEFWTINC+H S+EG ATFNWMRGHLFDYTCA+IIYEMCVQEP ATVT VRQQ
Sbjct: 239  EIQAHEPEEFWTINCSHKSDEGIATFNWMRGHLFDYTCAVIIYEMCVQEPIATVTKVRQQ 298

Query: 2196 EKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLH 2017
            EKLKYPP+PL+TIELEKRASR+FRMSSEHTMKVAEDLYQAGFISYPRTETD FS RTDLH
Sbjct: 299  EKLKYPPYPLNTIELEKRASRFFRMSSEHTMKVAEDLYQAGFISYPRTETDSFSQRTDLH 358

Query: 2016 TIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHH 1837
             IVQEQQ HPVWG YAQ+LL+P + LWRNP  GGHDDKAHPPIHPTKFS+GESGWS DHH
Sbjct: 359  AIVQEQQRHPVWGPYAQQLLEPGSGLWRNPGNGGHDDKAHPPIHPTKFSSGESGWSQDHH 418

Query: 1836 KVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMI 1657
            ++YELVVRHFLACVSQPA+GAET VEIDIAGE FSASGR I+AKNYLDVYRFE+WG S I
Sbjct: 419  RLYELVVRHFLACVSQPAVGAETNVEIDIAGELFSASGRAILAKNYLDVYRFESWGSSTI 478

Query: 1656 PTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYA 1477
            PTY  GQQF PT+LTLD+GVTRPPPLLSEADLLSCMDK GIGTDATMHDHIKKLLDRFYA
Sbjct: 479  PTYVSGQQFVPTSLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYA 538

Query: 1476 TKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQ 1297
            TKD +MRFSPT LGEALVMGYDDMGY+LWKPYLRA+ME DMKAVS GTK KAEVL   LQ
Sbjct: 539  TKDPNMRFSPTNLGEALVMGYDDMGYKLWKPYLRAVMERDMKAVSEGTKSKAEVLTTSLQ 598

Query: 1296 QMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPD 1117
            QMKACFVDARLNK KLFEAMAVFFERSNRS  +EQHA GEVVR CGLCQESDMVLR+  D
Sbjct: 599  QMKACFVDARLNKVKLFEAMAVFFERSNRSGGDEQHAAGEVVRPCGLCQESDMVLRRNRD 658

Query: 1116 GNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVN 937
            GNFMVGC+G+PQCRN VWLPGS+SEA+VTTNIC+TC+PGPVY+IQFKFR LEIPPNYN +
Sbjct: 659  GNFMVGCMGYPQCRNAVWLPGSLSEAVVTTNICNTCTPGPVYMIQFKFRPLEIPPNYNAS 718

Query: 936  HLGCIGGCDDILRQLVEVCGTGSR----NNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQT 769
            HLGCIGGCD+ILRQL+E+CGTGSR       S                          QT
Sbjct: 719  HLGCIGGCDEILRQLIEICGTGSRIPARGRGSSAPASNVQQSNSRHGEARHSACIYCHQT 778

Query: 768  GHSSGSYANAPESSRGRNSRSQ--EAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQA 595
            GHSS    +    SR    R    ++GE S+PCS+CG PC LRTANT  NRGRKFYSCQ+
Sbjct: 779  GHSSSDCPSQVSGSRSSRHRGMNPQSGEPSVPCSTCGTPCILRTANTANNRGRKFYSCQS 838

Query: 594  QGCNFFVWEDNAS--SGGTVPRG--SIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATG 427
            Q CNFFVWEDN +  +GG V RG  S+                          +F+SATG
Sbjct: 839  QECNFFVWEDNLNNVTGGNVQRGRTSVSASNTSRSGGRGRGGRGGSRAATATATFVSATG 898

Query: 426  EPISG-RCFVCGDPGHFANACPNRG 355
            +P++G RCFVCGDP HFAN CPNRG
Sbjct: 899  DPVTGRRCFVCGDPSHFANVCPNRG 923


>ref|XP_023917747.1| DNA topoisomerase 3-alpha isoform X1 [Quercus suber]
          Length = 937

 Score = 1399 bits (3622), Expect = 0.0
 Identities = 681/938 (72%), Positives = 763/938 (81%), Gaps = 24/938 (2%)
 Frame = -3

Query: 3096 MAGGGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQ 2917
            M+GGG   ++ L+VAEKPSVAK+V+ ILS+  ++GGLR R+GRSRYN+IFEF+Y+I  + 
Sbjct: 1    MSGGGRGGMKVLHVAEKPSVAKSVATILSR--NNGGLRTREGRSRYNKIFEFSYSINGRP 58

Query: 2916 VHMSFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQ 2737
             HM  TSVTGHLMEL+F+DRYRKWHSCDP DL+HAPV K+VPEDK +I++TLEEEAR CQ
Sbjct: 59   CHMLVTSVTGHLMELEFQDRYRKWHSCDPADLFHAPVHKFVPEDKLDIKRTLEEEARWCQ 118

Query: 2736 WLILWLDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFS 2557
            WL+LWLDCDREGENIAFEV+EVCT  N +L I RA FSALIDREIH +VQ LV PN+ F+
Sbjct: 119  WLVLWLDCDREGENIAFEVIEVCTAVNPHLTIKRAHFSALIDREIHEAVQCLVEPNKCFA 178

Query: 2556 DAVDARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQ------------ 2413
            DAVDARQEIDLRIGASFTRFQTMLLRDAFV+DF TD+ N++LSYGPCQ            
Sbjct: 179  DAVDARQEIDLRIGASFTRFQTMLLRDAFVIDFTTDDRNLVLSYGPCQRDASLLHLSPYV 238

Query: 2412 -FPTLGFIVERFWEVQSHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCV 2236
             FPTLGF+VER+WE+Q+HEPEEFWTINC+H S+EG ATFNWMRGHLFDYTCA+IIYEMCV
Sbjct: 239  QFPTLGFVVERYWEIQAHEPEEFWTINCSHKSDEGIATFNWMRGHLFDYTCAVIIYEMCV 298

Query: 2235 QEPTATVTNVRQQEKLKYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPR 2056
            QEP ATVT VRQQEKLKYPP+PL+TIELEKRASR+FRMSSEHTMKVAEDLYQAGFISYPR
Sbjct: 299  QEPIATVTKVRQQEKLKYPPYPLNTIELEKRASRFFRMSSEHTMKVAEDLYQAGFISYPR 358

Query: 2055 TETDCFSVRTDLHTIVQEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTK 1876
            TETD FS RTDLH IVQEQQ HPVWG YAQ+LL+P + LWRNP  GGHDDKAHPPIHPTK
Sbjct: 359  TETDSFSQRTDLHAIVQEQQRHPVWGPYAQQLLEPGSGLWRNPGNGGHDDKAHPPIHPTK 418

Query: 1875 FSAGESGWSPDHHKVYELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYL 1696
            FS+GESGWS DHH++YELVVRHFLACVSQPA+GAET VEIDIAGE FSASGR I+AKNYL
Sbjct: 419  FSSGESGWSQDHHRLYELVVRHFLACVSQPAVGAETNVEIDIAGELFSASGRAILAKNYL 478

Query: 1695 DVYRFETWGGSMIPTYNYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATM 1516
            DVYRFE+WG S IPTY  GQQF PT+LTLD+GVTRPPPLLSEADLLSCMDK GIGTDATM
Sbjct: 479  DVYRFESWGSSTIPTYVSGQQFVPTSLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATM 538

Query: 1515 HDHIKKLLDRFYATKDSSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMG 1336
            HDHIKKLLDRFYATKD +MRFSPT LGEALVMGYDDMGY+LWKPYLRA+ME DMKAVS G
Sbjct: 539  HDHIKKLLDRFYATKDPNMRFSPTNLGEALVMGYDDMGYKLWKPYLRAVMERDMKAVSEG 598

Query: 1335 TKRKAEVLEACLQQMKACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGL 1156
            TK KAEVL   LQQMKACFVDARLNK KLFEAMAVFFERSNRS  +EQHA GEVVR CGL
Sbjct: 599  TKSKAEVLTTSLQQMKACFVDARLNKVKLFEAMAVFFERSNRSGGDEQHAAGEVVRPCGL 658

Query: 1155 CQESDMVLRKKPDGNFMVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFK 976
            CQESDMVLR+  DGNFMVGC+G+PQCRN VWLPGS+SEA+VTTNIC+TC+PGPVY+IQFK
Sbjct: 659  CQESDMVLRRNRDGNFMVGCMGYPQCRNAVWLPGSLSEAVVTTNICNTCTPGPVYMIQFK 718

Query: 975  FRRLEIPPNYNVNHLGCIGGCDDILRQLVEVCGTGSR----NNSSVXXXXXXXXXXXXXX 808
            FR LEIPPNYN +HLGCIGGCD+ILRQL+E+CGTGSR       S               
Sbjct: 719  FRPLEIPPNYNASHLGCIGGCDEILRQLIEICGTGSRIPARGRGSSAPASNVQQSNSRHG 778

Query: 807  XXXXXXXXXAWQTGHSSGSYANAPESSRGRNSRSQ--EAGESSIPCSSCGAPCNLRTANT 634
                       QTGHSS    +    SR    R    ++GE S+PCS+CG PC LRTANT
Sbjct: 779  EARHSACIYCHQTGHSSSDCPSQVSGSRSSRHRGMNPQSGEPSVPCSTCGTPCILRTANT 838

Query: 633  PANRGRKFYSCQAQGCNFFVWEDNAS--SGGTVPRG--SIXXXXXXXXXXXXXXXXXXXX 466
              NRGRKFYSCQ+Q CNFFVWEDN +  +GG V RG  S+                    
Sbjct: 839  ANNRGRKFYSCQSQECNFFVWEDNLNNVTGGNVQRGRTSVSASNTSRSGGRGRGGRGGSR 898

Query: 465  XXXXXXSFMSATGEPISG-RCFVCGDPGHFANACPNRG 355
                  +F+SATG+P++G RCFVCGDP HFAN CPNRG
Sbjct: 899  AATATATFVSATGDPVTGRRCFVCGDPSHFANVCPNRG 936


>ref|XP_010270299.1| PREDICTED: DNA topoisomerase 3-alpha [Nelumbo nucifera]
          Length = 921

 Score = 1398 bits (3618), Expect = 0.0
 Identities = 678/922 (73%), Positives = 762/922 (82%), Gaps = 14/922 (1%)
 Frame = -3

Query: 3081 GRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHMSF 2902
            GR +R LNVAEKPSVAKAV+GILS+     GLRVR+GRSR+NRIFEF+Y+I+ Q  HM F
Sbjct: 4    GRTVRVLNVAEKPSVAKAVAGILSRNQ---GLRVRNGRSRFNRIFEFDYSIRGQHCHMLF 60

Query: 2901 TSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLILW 2722
            TSVTGHLMEL+FE+RYRKWHSCDP DLYHAPV+K+VP+DK +I++TLEEEARKCQWL+LW
Sbjct: 61   TSVTGHLMELEFEERYRKWHSCDPADLYHAPVRKFVPQDKLDIKRTLEEEARKCQWLVLW 120

Query: 2721 LDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFSDAVDA 2542
            LDCDREGENIAFEVVE+C+ AN +LNIWRARFSALIDREIH SVQ+LVRPNQLF+DAVDA
Sbjct: 121  LDCDREGENIAFEVVEICSAANNHLNIWRARFSALIDREIHESVQNLVRPNQLFADAVDA 180

Query: 2541 RQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEVQSH 2362
            RQEIDLRIGASFTRFQTMLL+DAFV+DFATD+ N++LSYGPCQFPTLGF+VER+WE+Q+H
Sbjct: 181  RQEIDLRIGASFTRFQTMLLKDAFVIDFATDDRNLVLSYGPCQFPTLGFVVERYWEIQAH 240

Query: 2361 EPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEKLKY 2182
            EPEEFWTINC+H  +EG ATFNWMRGH+FDYT A+IIYEMC  EPTATVT V+ QEKLKY
Sbjct: 241  EPEEFWTINCSHTLDEGIATFNWMRGHIFDYTYAVIIYEMCTLEPTATVTKVKNQEKLKY 300

Query: 2181 PPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTIVQE 2002
            PPHPL+TIELEKRASRYFRMSSEHTMKVAE+LYQ+GFISYPRTETDCFS RTDLH +VQE
Sbjct: 301  PPHPLNTIELEKRASRYFRMSSEHTMKVAEELYQSGFISYPRTETDCFSARTDLHAMVQE 360

Query: 2001 QQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKVYEL 1822
            QQGHP+WGSYAQRLLDPEA LWR+PS GGHDDKAHPPIHPTK+SAGESGWS DHH++YEL
Sbjct: 361  QQGHPLWGSYAQRLLDPEARLWRSPSNGGHDDKAHPPIHPTKYSAGESGWSQDHHRLYEL 420

Query: 1821 VVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPTYNY 1642
            VVRHFLACVSQPAIGAET VEIDIAGEQFS SGRVI+ KNYLDVYRFE+WGGSMIPTY+ 
Sbjct: 421  VVRHFLACVSQPAIGAETIVEIDIAGEQFSVSGRVILQKNYLDVYRFESWGGSMIPTYSV 480

Query: 1641 GQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSS 1462
            GQQF PT LTLD+GVTRPPPLLSEADLL+CMDKAGIGTDATMHDHIKKLLDR YATKDS+
Sbjct: 481  GQQFIPTALTLDSGVTRPPPLLSEADLLNCMDKAGIGTDATMHDHIKKLLDRCYATKDSN 540

Query: 1461 MRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQMKAC 1282
             RFSPT LGEALVMGYDDMGYELWKPYLR+MME DMKAVS+GTKRKAEVLE CLQQMKAC
Sbjct: 541  TRFSPTNLGEALVMGYDDMGYELWKPYLRSMMECDMKAVSIGTKRKAEVLETCLQQMKAC 600

Query: 1281 FVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGNFMV 1102
            F+DARLNK KL EAMA+FFER NR  +NEQ    ++VR C  CQES+MVL++KPDGNFMV
Sbjct: 601  FLDARLNKVKLLEAMAIFFERCNRPGTNEQQGAVDIVRPCSACQESNMVLKRKPDGNFMV 660

Query: 1101 GCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHLGCI 922
            GCLGFPQCRNVVWLPGS+S A VT +IC +CSPGPV+ IQFKFRRLEIP +Y+V+HLGCI
Sbjct: 661  GCLGFPQCRNVVWLPGSISTATVTNHICDSCSPGPVFKIQFKFRRLEIPSDYDVDHLGCI 720

Query: 921  GGCDDILRQLVEVCGTGSRN---NSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSSG- 754
            GGCD+ L+QL E+CGTGSRN    S+                          QTGHSS  
Sbjct: 721  GGCDETLKQLTEICGTGSRNPPSTSARGRGTTASSTNAQRVSTMQGVCEHCRQTGHSSND 780

Query: 753  --SYANAPESSRGRNSRSQEAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGCNF 580
              +  +  +S R R   SQ  G SS+ C+SCG  C LRTANT  NRGRKFYSCQ   CNF
Sbjct: 781  CPTQVSRRQSVRPRGRNSQRGG-SSVSCNSCGTLCALRTANTANNRGRKFYSCQE--CNF 837

Query: 579  FVWED----NASSGGTVPRGS---IXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEP 421
            FVWED    N + G +VP  S                               F+SATGEP
Sbjct: 838  FVWEDSVNGNNTQGQSVPHASYRRAANSGSNSSRRGRRGRGGRSGASTTNTRFVSATGEP 897

Query: 420  ISG-RCFVCGDPGHFANACPNR 358
            +SG  C++CGDP HFAN CP+R
Sbjct: 898  VSGMSCYICGDPSHFANVCPDR 919


>gb|EOX92637.1| Topoisomerase 3alpha isoform 1 [Theobroma cacao]
          Length = 914

 Score = 1395 bits (3612), Expect = 0.0
 Identities = 675/913 (73%), Positives = 751/913 (82%), Gaps = 7/913 (0%)
 Frame = -3

Query: 3072 LRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHMSFTSV 2893
            ++ LNVAEKPSVAK+VSGILS+     GLRVRDGRSR+NRIFEFNY+++ Q  HM FTSV
Sbjct: 5    IKVLNVAEKPSVAKSVSGILSRNQ---GLRVRDGRSRFNRIFEFNYSVRGQPCHMLFTSV 61

Query: 2892 TGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLILWLDC 2713
            TGHLMEL+FEDR+RKWHSCDP DLYHAPV+K+VPEDK +I++TLEEEAR+CQWL+LWLDC
Sbjct: 62   TGHLMELEFEDRFRKWHSCDPADLYHAPVRKHVPEDKMDIKRTLEEEARRCQWLVLWLDC 121

Query: 2712 DREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFSDAVDARQE 2533
            DREGENIAFEV++VC   N +L I RARFSALI+REIH++ Q+LV PN  FSDAVDARQE
Sbjct: 122  DREGENIAFEVIDVCRAVNCHLTIRRARFSALIEREIHHATQNLVDPNPWFSDAVDARQE 181

Query: 2532 IDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEVQSHEPE 2353
            IDLRIGASFTRFQTM+LRD FV+D ATD+ N++LSYGPCQFPTLGF+VER+WEVQSHEPE
Sbjct: 182  IDLRIGASFTRFQTMMLRDKFVIDSATDDRNLVLSYGPCQFPTLGFVVERYWEVQSHEPE 241

Query: 2352 EFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEKLKYPPH 2173
            EFWTINC+H  +EG ATFNWMRGHLFD+TCA+I+YEMCVQEP ATVT VR QEKLKYPP+
Sbjct: 242  EFWTINCSHKLDEGVATFNWMRGHLFDHTCAVIVYEMCVQEPNATVTKVRHQEKLKYPPY 301

Query: 2172 PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTIVQEQQG 1993
            PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFS RTDLH IVQEQQ 
Sbjct: 302  PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSSRTDLHAIVQEQQD 361

Query: 1992 HPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKVYELVVR 1813
            HP WGSYAQRLLDP  SLWRNPS GGHDDKAHPPIHPTKFSAGE  WS DH K+YELVVR
Sbjct: 362  HPEWGSYAQRLLDPGTSLWRNPSSGGHDDKAHPPIHPTKFSAGEHNWSQDHRKLYELVVR 421

Query: 1812 HFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPTYNYGQQ 1633
            HFLACVSQPA+GAETTVEIDIA EQFS SGRVI+ +NYLDVYR+E+WGGSMIPTY  GQQ
Sbjct: 422  HFLACVSQPAVGAETTVEIDIADEQFSTSGRVILERNYLDVYRYESWGGSMIPTYTLGQQ 481

Query: 1632 FTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSSMRF 1453
            F PT+LTLD GVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDS+ RF
Sbjct: 482  FIPTSLTLDTGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSNTRF 541

Query: 1452 SPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQMKACFVD 1273
            SPTKLGEALVMGYDDMGYELWKP LR+MME DMK VS+G KRK EVL  CLQQMKACF+D
Sbjct: 542  SPTKLGEALVMGYDDMGYELWKPNLRSMMEFDMKEVSVGNKRKDEVLATCLQQMKACFLD 601

Query: 1272 ARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGNFMVGCL 1093
            ARLNK KL EAMAVFFERSN+S  ++ H  GEVVR+CGLC+ES MVL+K  DGNFMVGCL
Sbjct: 602  ARLNKVKLLEAMAVFFERSNQSAGDDNHVAGEVVRQCGLCRESSMVLKKNRDGNFMVGCL 661

Query: 1092 GFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHLGCIGGC 913
            GFPQCRN +WLPGSV EA VT+NIC +C+PGPVYLIQFKFR+LEIPP +N NHLGCIGGC
Sbjct: 662  GFPQCRNAIWLPGSVLEAAVTSNICGSCNPGPVYLIQFKFRQLEIPPGFNANHLGCIGGC 721

Query: 912  DDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSSGSYANAPE 733
            DDILRQL+E+CGTGSR  S+                          QTGHSS    +   
Sbjct: 722  DDILRQLIEICGTGSR-MSARGRGPTTTSSNVQRNSSRQGACLYCQQTGHSSNDCPSQFS 780

Query: 732  SSRGRNSR-SQEAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGCNFFVWED--- 565
             SR   SR S + GE S+ CS+CG PC LRTANT  NRGRKFYSC +Q CNFF+WED   
Sbjct: 781  GSRNSRSRTSSQNGEPSVSCSTCGTPCVLRTANTANNRGRKFYSCPSQECNFFIWEDEHN 840

Query: 564  NASSGGTVPRGSI--XXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPISG-RCFVCG 394
            N + G ++PR  I                            +F+SATG+PISG RC+VCG
Sbjct: 841  NGTGGRSIPRAGINGSASNSSRGGGRGRGRFGQNGARAADVTFVSATGDPISGRRCYVCG 900

Query: 393  DPGHFANACPNRG 355
            DP HFAN CPNRG
Sbjct: 901  DPSHFANVCPNRG 913


>ref|XP_024025914.1| DNA topoisomerase 3-alpha [Morus notabilis]
          Length = 913

 Score = 1394 bits (3609), Expect = 0.0
 Identities = 670/915 (73%), Positives = 761/915 (83%), Gaps = 6/915 (0%)
 Frame = -3

Query: 3087 GGGRPLRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHM 2908
            GGGR + ALNVAEKPSVAK+V+ ILS+     G RVR+GRSRYN+IFEF Y+I    V M
Sbjct: 3    GGGRSITALNVAEKPSVAKSVATILSRNHQ--GFRVREGRSRYNKIFEFPYSINGVAVQM 60

Query: 2907 SFTSVTGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLI 2728
              TSVTGHLME++FEDR+RKWHSCDP  L+ AP++K VP+DK +I++TLE+EAR+CQWLI
Sbjct: 61   LVTSVTGHLMEIEFEDRFRKWHSCDPAHLFQAPIRKSVPDDKLDIKRTLEDEARRCQWLI 120

Query: 2727 LWLDCDREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFSDAV 2548
            LWLDCDREGENIAFEV+ VCT AN +L + RARFSALIDREIH + Q+LV+PN+ F+DAV
Sbjct: 121  LWLDCDREGENIAFEVINVCTAANPHLTLRRARFSALIDREIHEAAQNLVQPNKFFADAV 180

Query: 2547 DARQEIDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEVQ 2368
            DARQEIDLRIGASFTRFQTMLLRDAFV+D ATD+ N++LSYGPCQFPTLGF+VER+WEVQ
Sbjct: 181  DARQEIDLRIGASFTRFQTMLLRDAFVIDSATDDRNLVLSYGPCQFPTLGFVVERYWEVQ 240

Query: 2367 SHEPEEFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEKL 2188
            SHEPEEFW INC+H S+E  ATFNWMRGHLFDYTCA++IYEMCV+EPTATVTNVR+QEKL
Sbjct: 241  SHEPEEFWAINCSHRSDEVIATFNWMRGHLFDYTCAVVIYEMCVEEPTATVTNVRKQEKL 300

Query: 2187 KYPPHPLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTIV 2008
            KYPP+PL+TIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFS RT+LH IV
Sbjct: 301  KYPPYPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTNLHAIV 360

Query: 2007 QEQQGHPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKVY 1828
            +EQQGHP+WGSYAQRLLDP + LWRNP  GGHDDKAHPPIHPTKFSAGE  WS DH ++Y
Sbjct: 361  EEQQGHPIWGSYAQRLLDPGSGLWRNPGNGGHDDKAHPPIHPTKFSAGEPAWSQDHLRLY 420

Query: 1827 ELVVRHFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPTY 1648
            ELVVRHFLACVSQPA+GAETTVEIDIAGE FSASGRV++AKNYLD+YRFE+WGGS+IPTY
Sbjct: 421  ELVVRHFLACVSQPAVGAETTVEIDIAGELFSASGRVVLAKNYLDIYRFESWGGSLIPTY 480

Query: 1647 NYGQQFTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKD 1468
              GQQF PTTLTLD+GVTRPPPLLSEADLLSCMDK GIGTDATMHDHIKKLLDR YATKD
Sbjct: 481  VLGQQFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRCYATKD 540

Query: 1467 SSMRFSPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQMK 1288
            ++ RFSPT LGEALVMGYDDMGY+LWKPYLRA+ME DMKAVS G K KAE+LE CLQQMK
Sbjct: 541  ANTRFSPTNLGEALVMGYDDMGYKLWKPYLRAVMERDMKAVSEGAKSKAELLETCLQQMK 600

Query: 1287 ACFVDARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGNF 1108
            ACF+DARLNK KL E MA+FFERSNRS+ +EQH   EVVR CGLC ESDMVL++  DGNF
Sbjct: 601  ACFLDARLNKAKLLETMAIFFERSNRSSGDEQHGPVEVVRPCGLCHESDMVLKQNRDGNF 660

Query: 1107 MVGCLGFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHLG 928
            MVGC+G+PQCRNVVWLPGSVSEA VT+NIC++C+PGPV+LIQFKFRRLEIPP+YN +HLG
Sbjct: 661  MVGCMGYPQCRNVVWLPGSVSEAAVTSNICNSCTPGPVHLIQFKFRRLEIPPDYNASHLG 720

Query: 927  CIGGCDDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSSG-- 754
            CIGGCD ILRQL+E+CGTG+R  S+                          QTGHSS   
Sbjct: 721  CIGGCDAILRQLIEICGTGTR-MSARGRGPTASSGSAQQTNTRQGVCIYCHQTGHSSSDC 779

Query: 753  -SYANAPESSRGRNSRSQEAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGCNFF 577
             S  +AP+S+R R +  Q +G+SSIPC +CGAPC LRTANT  NRGRKFYSCQ+Q CNFF
Sbjct: 780  PSQVSAPQSTRSRRANVQ-SGDSSIPCGTCGAPCPLRTANTANNRGRKFYSCQSQECNFF 838

Query: 576  VWED---NASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPISGRC 406
            VWED   N S G +VPR +                           +F+SATG+P SGRC
Sbjct: 839  VWEDSLSNGSGGRSVPRANTRAPASNSSRNGGHGRGGRGTTRGAGATFVSATGDPASGRC 898

Query: 405  FVCGDPGHFANACPN 361
            FVCGDP HFAN CPN
Sbjct: 899  FVCGDPSHFANVCPN 913


>ref|XP_007048480.2| PREDICTED: DNA topoisomerase 3-alpha isoform X2 [Theobroma cacao]
          Length = 916

 Score = 1393 bits (3606), Expect = 0.0
 Identities = 674/915 (73%), Positives = 752/915 (82%), Gaps = 9/915 (0%)
 Frame = -3

Query: 3072 LRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHMSFTSV 2893
            ++ LNVAEKPSVAK+VSGILS+     GLRVRDGRSR+NRIFEFNY+++ Q  HM FTSV
Sbjct: 5    IKVLNVAEKPSVAKSVSGILSRNQ---GLRVRDGRSRFNRIFEFNYSVRGQPCHMLFTSV 61

Query: 2892 TGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLILWLDC 2713
            TGHLMEL+FEDR+RKWHSCDP DLYHAPV+K+VPEDK +I++TLEEEAR+CQWL+LWLDC
Sbjct: 62   TGHLMELEFEDRFRKWHSCDPADLYHAPVRKHVPEDKMDIKRTLEEEARRCQWLVLWLDC 121

Query: 2712 DREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFSDAVDARQE 2533
            DREGENIAFEV++VC   N +L I RARFSALI+REIH++ Q+LV PN  FSDAVDARQE
Sbjct: 122  DREGENIAFEVIDVCRAVNCHLTIRRARFSALIEREIHHATQNLVDPNPWFSDAVDARQE 181

Query: 2532 IDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEVQSHEPE 2353
            IDLRIGASFTRFQTM+LRD FV+D ATD+ N++LSYGPCQFPTLGF+VER+WEVQSHEPE
Sbjct: 182  IDLRIGASFTRFQTMMLRDKFVIDSATDDRNLVLSYGPCQFPTLGFVVERYWEVQSHEPE 241

Query: 2352 EFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEKLKYPPH 2173
            EFWTINC+H  +EG ATFNWMRGHLFD+TCA+I+YEMCVQEP ATVT VR QEKLKYPP+
Sbjct: 242  EFWTINCSHKLDEGVATFNWMRGHLFDHTCAVIVYEMCVQEPNATVTKVRHQEKLKYPPY 301

Query: 2172 PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTIVQEQQG 1993
            PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFS RTDLH IVQEQQ 
Sbjct: 302  PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSSRTDLHAIVQEQQD 361

Query: 1992 HPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKVYELVVR 1813
            HP WGSYAQRLLDP  SLWRNPS GGHDDKAHPPIHPTKFSAGE  WS DH K+YELVVR
Sbjct: 362  HPEWGSYAQRLLDPGTSLWRNPSSGGHDDKAHPPIHPTKFSAGEHNWSQDHRKLYELVVR 421

Query: 1812 HFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPTYNYGQQ 1633
            HFLACVSQPA+GAETTVEIDIA EQFS SGRVI+ +NYLDVYR+E+WGGSMIPTY  GQQ
Sbjct: 422  HFLACVSQPAVGAETTVEIDIADEQFSTSGRVILERNYLDVYRYESWGGSMIPTYTLGQQ 481

Query: 1632 FTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSSMRF 1453
            F P +LTLD GVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDS+ RF
Sbjct: 482  FIPASLTLDTGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSNTRF 541

Query: 1452 SPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQMKACFVD 1273
            SPTKLGEALVMGYDDMGYELWKP LR+MME DMK VS+G KRK EVL  CLQQMKACF+D
Sbjct: 542  SPTKLGEALVMGYDDMGYELWKPNLRSMMEFDMKEVSVGNKRKDEVLATCLQQMKACFLD 601

Query: 1272 ARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGNFMVGCL 1093
            ARLNK KL EAMAVFFERSN++  ++ HA GEVVR+CGLC+ES MVL+K  DGNFMVGCL
Sbjct: 602  ARLNKVKLLEAMAVFFERSNQAAGDDNHAAGEVVRQCGLCRESSMVLKKNRDGNFMVGCL 661

Query: 1092 GFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHLGCIGGC 913
            GFPQCRN +WLPGSV EA VT+NIC +C+PGPVYLIQFKFR+LEIPP +N NHLGCIGGC
Sbjct: 662  GFPQCRNAIWLPGSVLEAAVTSNICGSCNPGPVYLIQFKFRQLEIPPGFNANHLGCIGGC 721

Query: 912  DDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSSGSYANAPE 733
            DDILRQL+E+CGTGSR  S+                          QTGHSS    +   
Sbjct: 722  DDILRQLIEICGTGSR-MSARGRGPTTTSSNVQRNSSRQGACLYCQQTGHSSNDCPSQFS 780

Query: 732  SSRGRNSR-SQEAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGCNFFVWED--- 565
             SR   SR + + GE S+ CS+CG PC LRTANT  NRGRKFYSC +Q CNFF+WED   
Sbjct: 781  GSRNSRSRTNSQNGEPSVLCSTCGTPCVLRTANTANNRGRKFYSCPSQECNFFIWEDEHN 840

Query: 564  NASSGGTVPR----GSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPISG-RCFV 400
            N + G ++PR    GS                           +F+SATG+PISG RC+V
Sbjct: 841  NGTGGRSIPRAGINGSASNSSRGGGRGRGRGRFGQNGARAADVTFVSATGDPISGRRCYV 900

Query: 399  CGDPGHFANACPNRG 355
            CGDP HFAN CPNRG
Sbjct: 901  CGDPSHFANVCPNRG 915


>ref|XP_017969682.1| PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Theobroma cacao]
          Length = 919

 Score = 1392 bits (3604), Expect = 0.0
 Identities = 676/918 (73%), Positives = 755/918 (82%), Gaps = 12/918 (1%)
 Frame = -3

Query: 3072 LRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHMSFTSV 2893
            ++ LNVAEKPSVAK+VSGILS+     GLRVRDGRSR+NRIFEFNY+++ Q  HM FTSV
Sbjct: 5    IKVLNVAEKPSVAKSVSGILSRNQ---GLRVRDGRSRFNRIFEFNYSVRGQPCHMLFTSV 61

Query: 2892 TGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLILWLDC 2713
            TGHLMEL+FEDR+RKWHSCDP DLYHAPV+K+VPEDK +I++TLEEEAR+CQWL+LWLDC
Sbjct: 62   TGHLMELEFEDRFRKWHSCDPADLYHAPVRKHVPEDKMDIKRTLEEEARRCQWLVLWLDC 121

Query: 2712 DREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFSDAVDARQE 2533
            DREGENIAFEV++VC   N +L I RARFSALI+REIH++ Q+LV PN  FSDAVDARQE
Sbjct: 122  DREGENIAFEVIDVCRAVNCHLTIRRARFSALIEREIHHATQNLVDPNPWFSDAVDARQE 181

Query: 2532 IDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEVQSHEPE 2353
            IDLRIGASFTRFQTM+LRD FV+D ATD+ N++LSYGPCQFPTLGF+VER+WEVQSHEPE
Sbjct: 182  IDLRIGASFTRFQTMMLRDKFVIDSATDDRNLVLSYGPCQFPTLGFVVERYWEVQSHEPE 241

Query: 2352 EFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEKLKYPPH 2173
            EFWTINC+H  +EG ATFNWMRGHLFD+TCA+I+YEMCVQEP ATVT VR QEKLKYPP+
Sbjct: 242  EFWTINCSHKLDEGVATFNWMRGHLFDHTCAVIVYEMCVQEPNATVTKVRHQEKLKYPPY 301

Query: 2172 PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTIVQEQQG 1993
            PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFS RTDLH IVQEQQ 
Sbjct: 302  PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSSRTDLHAIVQEQQD 361

Query: 1992 HPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKVYELVVR 1813
            HP WGSYAQRLLDP  SLWRNPS GGHDDKAHPPIHPTKFSAGE  WS DH K+YELVVR
Sbjct: 362  HPEWGSYAQRLLDPGTSLWRNPSSGGHDDKAHPPIHPTKFSAGEHNWSQDHRKLYELVVR 421

Query: 1812 HFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPTYNYGQQ 1633
            HFLACVSQPA+GAETTVEIDIA EQFS SGRVI+ +NYLDVYR+E+WGGSMIPTY  GQQ
Sbjct: 422  HFLACVSQPAVGAETTVEIDIADEQFSTSGRVILERNYLDVYRYESWGGSMIPTYTLGQQ 481

Query: 1632 FTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSSMRF 1453
            F P +LTLD GVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDS+ RF
Sbjct: 482  FIPASLTLDTGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSNTRF 541

Query: 1452 SPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQMKACFVD 1273
            SPTKLGEALVMGYDDMGYELWKP LR+MME DMK VS+G KRK EVL  CLQQMKACF+D
Sbjct: 542  SPTKLGEALVMGYDDMGYELWKPNLRSMMEFDMKEVSVGNKRKDEVLATCLQQMKACFLD 601

Query: 1272 ARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGNFMVGCL 1093
            ARLNK KL EAMAVFFERSN++  ++ HA GEVVR+CGLC+ES MVL+K  DGNFMVGCL
Sbjct: 602  ARLNKVKLLEAMAVFFERSNQAAGDDNHAAGEVVRQCGLCRESSMVLKKNRDGNFMVGCL 661

Query: 1092 GFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHLGCIGGC 913
            GFPQCRN +WLPGSV EA VT+NIC +C+PGPVYLIQFKFR+LEIPP +N NHLGCIGGC
Sbjct: 662  GFPQCRNAIWLPGSVLEAAVTSNICGSCNPGPVYLIQFKFRQLEIPPGFNANHLGCIGGC 721

Query: 912  DDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSSG---SYAN 742
            DDILRQL+E+CGTGSR  S+                          QTGHSS    S  +
Sbjct: 722  DDILRQLIEICGTGSR-MSARGRGPTTTSSNVQRNSSRQGACLYCQQTGHSSNDCPSQFS 780

Query: 741  APESSRGR-NSRSQEAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGCNFFVWED 565
               +SR R NS++   GE S+ CS+CG PC LRTANT  NRGRKFYSC +Q CNFF+WED
Sbjct: 781  GSRNSRSRTNSQNGMQGEPSVLCSTCGTPCVLRTANTANNRGRKFYSCPSQECNFFIWED 840

Query: 564  ---NASSGGTVPR----GSIXXXXXXXXXXXXXXXXXXXXXXXXXXSFMSATGEPISG-R 409
               N + G ++PR    GS                           +F+SATG+PISG R
Sbjct: 841  EHNNGTGGRSIPRAGINGSASNSSRGGGRGRGRGRFGQNGARAADVTFVSATGDPISGRR 900

Query: 408  CFVCGDPGHFANACPNRG 355
            C+VCGDP HFAN CPNRG
Sbjct: 901  CYVCGDPSHFANVCPNRG 918


>ref|XP_021274352.1| DNA topoisomerase 3-alpha isoform X2 [Herrania umbratica]
          Length = 913

 Score = 1389 bits (3594), Expect = 0.0
 Identities = 670/912 (73%), Positives = 749/912 (82%), Gaps = 6/912 (0%)
 Frame = -3

Query: 3072 LRALNVAEKPSVAKAVSGILSKTPSSGGLRVRDGRSRYNRIFEFNYTIQNQQVHMSFTSV 2893
            ++ LNVAEKPSVAK+VSGILS+     GLRVRDGRSR+NRIFEFNY+++ Q  HM FTSV
Sbjct: 5    IKVLNVAEKPSVAKSVSGILSRNQ---GLRVRDGRSRFNRIFEFNYSVRGQPCHMLFTSV 61

Query: 2892 TGHLMELDFEDRYRKWHSCDPVDLYHAPVKKYVPEDKSEIEKTLEEEARKCQWLILWLDC 2713
            TGHLMEL+FEDR+RKWHSCDP DLYHAPV+K+VPEDK +I++TLEEEAR+CQWL+LWLDC
Sbjct: 62   TGHLMELEFEDRFRKWHSCDPADLYHAPVRKHVPEDKMDIKRTLEEEARRCQWLVLWLDC 121

Query: 2712 DREGENIAFEVVEVCTRANRNLNIWRARFSALIDREIHYSVQHLVRPNQLFSDAVDARQE 2533
            DREGENIAFEV++VC   N +L   RARFSALI+REIH+++Q+LV PNQ FSDAVDARQE
Sbjct: 122  DREGENIAFEVIDVCRAVNCHLTTRRARFSALIEREIHHAMQNLVDPNQWFSDAVDARQE 181

Query: 2532 IDLRIGASFTRFQTMLLRDAFVLDFATDNTNVILSYGPCQFPTLGFIVERFWEVQSHEPE 2353
            IDLRIGASFTRFQTM+LRD FV+D ATD+ N++LSYGPCQFPTLGF+VER+WEVQSHEPE
Sbjct: 182  IDLRIGASFTRFQTMMLRDKFVIDSATDDRNLVLSYGPCQFPTLGFVVERYWEVQSHEPE 241

Query: 2352 EFWTINCTHNSEEGTATFNWMRGHLFDYTCAMIIYEMCVQEPTATVTNVRQQEKLKYPPH 2173
            EFWTINC+H  +EG ATFNWMRGHLFD+TC +IIYEMCVQEPTATVT VR QEK KYPP+
Sbjct: 242  EFWTINCSHKLDEGVATFNWMRGHLFDHTCVVIIYEMCVQEPTATVTAVRHQEKRKYPPY 301

Query: 2172 PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSVRTDLHTIVQEQQG 1993
            PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFS RTDLH IVQEQQ 
Sbjct: 302  PLSTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSSRTDLHAIVQEQQE 361

Query: 1992 HPVWGSYAQRLLDPEASLWRNPSGGGHDDKAHPPIHPTKFSAGESGWSPDHHKVYELVVR 1813
            HP WGSYAQRLLDP  SLWRNPS GGHDDKAHPPIHPTKFS GE  WS DH K+Y+LVVR
Sbjct: 362  HPEWGSYAQRLLDPRTSLWRNPSSGGHDDKAHPPIHPTKFSTGEHNWSQDHRKLYDLVVR 421

Query: 1812 HFLACVSQPAIGAETTVEIDIAGEQFSASGRVIIAKNYLDVYRFETWGGSMIPTYNYGQQ 1633
            HFLACVSQPA+GAETTVEIDIAGE FS SGRVI+ +NYLDVYR+E+WGGSMIPTY  GQQ
Sbjct: 422  HFLACVSQPAVGAETTVEIDIAGELFSTSGRVILERNYLDVYRYESWGGSMIPTYTLGQQ 481

Query: 1632 FTPTTLTLDAGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSSMRF 1453
            F PT+LTLD GVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDS+ RF
Sbjct: 482  FIPTSLTLDTGVTRPPPLLSEADLLSCMDKAGIGTDATMHDHIKKLLDRFYATKDSNTRF 541

Query: 1452 SPTKLGEALVMGYDDMGYELWKPYLRAMMESDMKAVSMGTKRKAEVLEACLQQMKACFVD 1273
            SPTKLGEALVMGYDDMG+ELWKP LR+MME DMK VS+G KRK EVL  CLQQMKACF+D
Sbjct: 542  SPTKLGEALVMGYDDMGHELWKPNLRSMMEFDMKEVSVGNKRKDEVLATCLQQMKACFLD 601

Query: 1272 ARLNKGKLFEAMAVFFERSNRSNSNEQHAIGEVVRKCGLCQESDMVLRKKPDGNFMVGCL 1093
            ARLNK KL EA+AVFFERSN++  ++ HA GEVVR+CGLC+ES MVL+K  DGNFMVGCL
Sbjct: 602  ARLNKVKLLEALAVFFERSNQAAGDDNHAAGEVVRQCGLCRESSMVLKKNRDGNFMVGCL 661

Query: 1092 GFPQCRNVVWLPGSVSEAIVTTNICSTCSPGPVYLIQFKFRRLEIPPNYNVNHLGCIGGC 913
            GFPQCRN +WLPGSV EA VT+NIC +C+PGPVYLIQFKFR+LEIPP +N NHLGCIGGC
Sbjct: 662  GFPQCRNAIWLPGSVLEAAVTSNICGSCNPGPVYLIQFKFRQLEIPPGFNANHLGCIGGC 721

Query: 912  DDILRQLVEVCGTGSRNNSSVXXXXXXXXXXXXXXXXXXXXXXXAWQTGHSSGSYANAPE 733
            DD LRQL+E+CGTGSR  S+                          QTGH S    +   
Sbjct: 722  DDTLRQLIEICGTGSRM-SARGRGPTTTSSNVQRSSSRQGACLYCQQTGHFSNDCPSQFS 780

Query: 732  SSRGRNSRSQ-EAGESSIPCSSCGAPCNLRTANTPANRGRKFYSCQAQGCNFFVWED--- 565
             SR   SR+  + GE S+PCS+CG PC LRTANT  NRGRKFYSC +Q CNFF+WED   
Sbjct: 781  GSRNSRSRTNSQNGEPSVPCSTCGTPCVLRTANTANNRGRKFYSCPSQDCNFFIWEDDHN 840

Query: 564  NASSGGTVPRGSIXXXXXXXXXXXXXXXXXXXXXXXXXXS-FMSATGEPISGR-CFVCGD 391
            N S G ++PR  I                            F+SATG+PISGR C+VCGD
Sbjct: 841  NGSGGRSIPRAGINGSASNSSRGGGGRGRFGQNGARAADVTFVSATGDPISGRRCYVCGD 900

Query: 390  PGHFANACPNRG 355
            P HFAN CPNRG
Sbjct: 901  PSHFANVCPNRG 912