BLASTX 2.2.26 [Sep-21-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Rehmannia27_contig00044127
         (3278 letters)

Database: ./nr 
           84,704,028 sequences; 31,038,470,784 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

emb|CBI24922.3| unnamed protein product [Vitis vinifera]             1005   0.0  
ref|XP_010241214.1| PREDICTED: DNA topoisomerase 2-like isoform ...   997   0.0  
ref|XP_010241213.1| PREDICTED: DNA topoisomerase 2-like isoform ...   996   0.0  
ref|XP_002274267.1| PREDICTED: DNA topoisomerase 2 [Vitis vinifera]   993   0.0  
emb|CDP07797.1| unnamed protein product [Coffea canephora]            979   0.0  
ref|XP_009630917.1| PREDICTED: LOW QUALITY PROTEIN: DNA topoisom...   972   0.0  
ref|XP_009800897.1| PREDICTED: LOW QUALITY PROTEIN: DNA topoisom...   971   0.0  
ref|XP_008779357.1| PREDICTED: DNA topoisomerase 2, partial [Pho...   970   0.0  
ref|XP_015163346.1| PREDICTED: DNA topoisomerase 2 isoform X1 [S...   969   0.0  
ref|XP_010023678.1| PREDICTED: DNA topoisomerase 2-like [Eucalyp...   968   0.0  
ref|XP_010920068.1| PREDICTED: DNA topoisomerase 2 [Elaeis guine...   968   0.0  
ref|XP_015163347.1| PREDICTED: DNA topoisomerase 2 isoform X2 [S...   966   0.0  
ref|XP_006345427.1| PREDICTED: DNA topoisomerase 2 isoform X3 [S...   965   0.0  
gb|AAN85207.1| DNA topoisomerase II [Nicotiana tabacum] gi|26984...   964   0.0  
ref|XP_010257162.1| PREDICTED: LOW QUALITY PROTEIN: DNA topoisom...   964   0.0  
ref|XP_015060910.1| PREDICTED: DNA topoisomerase 2 isoform X2 [S...   962   0.0  
ref|XP_004229644.1| PREDICTED: DNA topoisomerase 2 isoform X2 [S...   959   0.0  
ref|XP_010023597.1| PREDICTED: DNA topoisomerase 2-like [Eucalyp...   959   0.0  
ref|XP_015060904.1| PREDICTED: DNA topoisomerase 2 isoform X1 [S...   959   0.0  
ref|XP_010324649.1| PREDICTED: DNA topoisomerase 2 isoform X1 [S...   956   0.0  

>emb|CBI24922.3| unnamed protein product [Vitis vinifera]
          Length = 1452

 Score = 1005 bits (2599), Expect = 0.0
 Identities = 550/962 (57%), Positives = 671/962 (69%), Gaps = 20/962 (2%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGR+ YGVFPLRGKLLNVR+A   QI  N EIQ+I +IL L+ GK Y+S++SLR
Sbjct: 465  MAGISVVGRNHYGVFPLRGKLLNVRDAQKKQILENAEIQNIKQILGLQQGKEYDSIKSLR 524

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  HS WPSLLKIP+FL+EFITPI+KAT R G+VLSFY
Sbjct: 525  YGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHRNGRVLSFY 584

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            S+PEYE+WK+SL GN SGWSIKYYKGLGTSTSKEGKEYF+DL KHKKDF+W+D+KD DAI
Sbjct: 585  SMPEYESWKESLGGNASGWSIKYYKGLGTSTSKEGKEYFKDLGKHKKDFMWVDEKDGDAI 644

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+  K WL++++PGTYLDQKEK IKYSDFV+KELI FS+ADL+RSIPSMVDG
Sbjct: 645  ELAFSKKKIEERKNWLRQFQPGTYLDQKEKLIKYSDFVNKELILFSMADLQRSIPSMVDG 704

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRNFIKEAK+AQ SGYVSEHSAYHHGEQSLA+TI+GMAQD++GSNNI
Sbjct: 705  LKPGQRKILFCSFKRNFIKEAKIAQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNI 764

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NLL PNGQFGTRHQGGKDHASARYIYT LSPITRFLF K+DD LL YLNEDGQS+EPTWY
Sbjct: 765  NLLLPNGQFGTRHQGGKDHASARYIYTRLSPITRFLFPKDDDILLDYLNEDGQSIEPTWY 824

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            VP IPMVLVNG+EGIGTGWS+ IPNYNPRDI+ANVR  LN E MEPM PWY+GF+GTIE 
Sbjct: 825  VPTIPMVLVNGSEGIGTGWSSSIPNYNPRDIIANVRRLLNGEMMEPMDPWYRGFRGTIEK 884

Query: 1282 TN-TKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKD 1458
            T+ TK     Y VKGIIEEVN+TT+RI+ELPVRK T++YK+FL+ +++   + K+ FIKD
Sbjct: 885  TDPTKQESVGYTVKGIIEEVNETTLRISELPVRKWTQDYKEFLESIMTGNDKIKDPFIKD 944

Query: 1459 FREFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPE 1638
            ++E NDD TVHFE+ MSE+NL MAK+EGL++KFKL+T ISTSNMHLF+  G + KY +PE
Sbjct: 945  YKEHNDDTTVHFEVIMSEENLLMAKQEGLLQKFKLTTKISTSNMHLFDSNGTIKKYETPE 1004

Query: 1639 KIIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDE 1818
            +I+EEF  LRLEFYEKRK  +L           NKVRFI  V++G+II+ NRKR+DL  E
Sbjct: 1005 QILEEFFHLRLEFYEKRKRVLLDNLELELLKLENKVRFILGVVRGEIIVSNRKRADLFHE 1064

Query: 1819 LKQKXXXXXXXXXXXXXXXXSMPIGTLTMEKVQELCAQRKKLNVEVDGLRHATPKSLWLK 1998
            L QK                SM IGTLT+EKVQELCA R KLN  VD L+ ATPK+LW+ 
Sbjct: 1065 LHQK------VRATDYEYLLSMAIGTLTLEKVQELCADRDKLNKGVDDLKKATPKALWIT 1118

Query: 1999 DLDSLEQKLNLQSKIYDMPEK-----RLEVNAEISKRPKRTMRKKQESSEKKANNKDGLA 2163
            DLD+LE++L+ Q K     E+     +  V +E   +  R   K    + KKANN +  A
Sbjct: 1119 DLDALERELDEQDKNDARAEETRKQLKSRVMSEAGMKVSRQAPKNPRKNNKKANNAEPAA 1178

Query: 2164 EKHTVPSDCT---GKVPEAVELEGITTGR------DEISTPNPPSLDVNEDRGLEQKEEQ 2316
            E   V +        VPE V+ +G    R       E+ T      D +E   L+++   
Sbjct: 1179 ETMDVSASSAMEMESVPEVVKPKGRAAPRKAPAKKKEMPTSVLKDEDDDEVHELKERLAA 1238

Query: 2317 PKQSSSPDTSREPKMSVLQVP---PEDNTRRNSADNLN-APIIEISDTEVDCENKQQTAE 2484
                SSPD S   +  V QVP    ++ +RR +A     A   EISD + D E+ +    
Sbjct: 1239 YNLESSPDGSAAMEAEVPQVPAARKKEPSRRAAAQKKPLASFTEISDDDEDDEDFE---- 1294

Query: 2485 TVIEISDSEVVCEDEVPNTRINNPSGDEKLEDQIASTVESGMTSVDKTSQENKNRHVMIT 2664
             V E+S S+V  +          P+ + K     A+   +   + +K    NK +  ++ 
Sbjct: 1295 -VEEVSASDVKKKGG------RKPAANAK----AAAAKPAAAAAKNKRGAANKQQPQLL- 1342

Query: 2665 RKRANMSRQNGATSLANGSSGSVLKAVENIMVSPEKKLRRTSSFPFRKKKNYSPTKNGQN 2844
                      G T L       + K  E + +SPEKK+R+  + PF KK        G+ 
Sbjct: 1343 ----------GQTLLT-----EIFKPAETLGISPEKKVRKMRASPFNKKSGSVLGSTGEE 1387

Query: 2845 KE 2850
             E
Sbjct: 1388 DE 1389


>ref|XP_010241214.1| PREDICTED: DNA topoisomerase 2-like isoform X2 [Nelumbo nucifera]
          Length = 1503

 Score =  997 bits (2578), Expect = 0.0
 Identities = 547/983 (55%), Positives = 668/983 (67%), Gaps = 54/983 (5%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGR+ YGVFPLRGKLLNVREA + QI  N EIQ+I +IL L++GK Y+SV+SLR
Sbjct: 469  MAGISVVGRNNYGVFPLRGKLLNVREATHKQIMDNAEIQNIKQILGLQHGKEYDSVKSLR 528

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  HS WPSLLKIP+FL+EFITPI+KAT + G+VLSFY
Sbjct: 529  YGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHKNGKVLSFY 588

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            S+PEYE+WK  L GN SGWSIKYYKGLGTSTSKEGKEYF+DL KHKKDFLW+D +D DAI
Sbjct: 589  SMPEYESWKX-LGGNASGWSIKYYKGLGTSTSKEGKEYFKDLHKHKKDFLWVDDRDGDAI 647

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+A K WL+++EPGT LDQKEK IKYSDFV+KELI FS+ADL+RSIPSMVDG
Sbjct: 648  ELAFSKKKIEARKNWLRQFEPGTCLDQKEKLIKYSDFVNKELILFSMADLQRSIPSMVDG 707

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRN IKEAKVAQ SGYVSEHSAYHHGEQSL +TI+GMAQDY+GSNNI
Sbjct: 708  LKPGQRKILFCAFKRNLIKEAKVAQFSGYVSEHSAYHHGEQSLMSTIIGMAQDYVGSNNI 767

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NL QPNGQFGTRHQGGKDHASARYIYT LSPITRFLF K DD LL YLNEDGQS+EPTWY
Sbjct: 768  NLFQPNGQFGTRHQGGKDHASARYIYTRLSPITRFLFPKGDDILLDYLNEDGQSIEPTWY 827

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            +P+IP VLVNG+EGIGTGWS+YIPNYNPRDIVAN++  LN EPMEPM PWYKGFKG IE 
Sbjct: 828  MPIIPTVLVNGSEGIGTGWSSYIPNYNPRDIVANIKRLLNGEPMEPMDPWYKGFKGLIEK 887

Query: 1282 TNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKDF 1461
            T TK+AG SY V GIIEE+N+TT+RITELP+R+ T++YK+FL+ +++   + KE FIKD+
Sbjct: 888  TATKEAGSSYTVSGIIEEINETTLRITELPIRRWTQDYKEFLESIMTGNDKIKEPFIKDY 947

Query: 1462 REFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPEK 1641
            +E NDD TVHFEI +SE+NL MAK+EGL++KFKL+TTISTSNMHLF+PKG + KY +PE+
Sbjct: 948  KEHNDDTTVHFEIILSEENLMMAKQEGLMKKFKLTTTISTSNMHLFDPKGTIKKYDNPEQ 1007

Query: 1642 IIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDEL 1821
            I+EEF  LRLEFYEKRK   L           NKVRFI  V++G+II+ NRKR DL  EL
Sbjct: 1008 ILEEFFHLRLEFYEKRKKTQLDNLELDLLKLDNKVRFILGVVKGEIIVSNRKRVDLFLEL 1067

Query: 1822 KQK-------------------------------XXXXXXXXXXXXXXXXSMPIGTLTME 1908
            +QK                                               SM IGTLT+E
Sbjct: 1068 QQKGFTPFPKKTKALEAAVAGANEDGEENEENSEVVSSRGVRASDYEYLLSMAIGTLTLE 1127

Query: 1909 KVQELCAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQS-------------KIYD 2049
            KVQELC+ R KLN EV+ LR ATP SLW+ DLD+LE++L+ Q              K   
Sbjct: 1128 KVQELCSDRDKLNHEVEELRKATPNSLWMNDLDALEKELDEQDKNDAQAEEARKELKNRV 1187

Query: 2050 MPEKRLEVNAEISKRPKRTMRKKQESSEKKANNKDGLAEKHTVPSDCTGKVPEAVELEGI 2229
            M E  ++ + +  K P++T  KK  +SE    +    +    + +     VPE V+ +G 
Sbjct: 1188 MSEAGMKASRQAPKNPRKTNAKKPSTSETVTESVAASSVGSAMET-----VPEVVKPKG- 1241

Query: 2230 TTGRDE---ISTPNPPSLDVNEDR----GLEQKEEQPKQSSSPDTSREPKMSVLQVP--P 2382
              GR +       N   +D +ED      L+++       SSP+ S   +  V +VP   
Sbjct: 1242 RGGRPKKAPAKKDNMRLVDSDEDDVDVIELKERLAAYNLDSSPEQSAVMETEVAKVPAKK 1301

Query: 2383 EDNTRRNSADNLNAPIIEISDTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSG 2562
            ++ ++R +A    +   EISD     ++     +T+ E S  E+V               
Sbjct: 1302 KEPSKRAAAQKQPSSYTEISD-----DDDGMDVQTIREESIGEIV--------------S 1342

Query: 2563 DEKLEDQIASTVESGMTSVDKTSQENKNRHVMITRKRANMSRQNGATSLANGSSGSVLKA 2742
            DE  E ++    + G       +     +    T+KR   ++Q     L       +LK 
Sbjct: 1343 DEDFEPEVEEAPKGGRGGRKPAA---NGKAAASTKKRGAANKQTSV--LGQKKITDLLKP 1397

Query: 2743 VENIMVSPEKKLRRTSSFPFRKK 2811
             EN  VSPEKK+R+  + PF KK
Sbjct: 1398 AENAGVSPEKKVRKMRASPFNKK 1420


>ref|XP_010241213.1| PREDICTED: DNA topoisomerase 2-like isoform X1 [Nelumbo nucifera]
          Length = 1504

 Score =  996 bits (2576), Expect = 0.0
 Identities = 547/984 (55%), Positives = 669/984 (67%), Gaps = 55/984 (5%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGR+ YGVFPLRGKLLNVREA + QI  N EIQ+I +IL L++GK Y+SV+SLR
Sbjct: 469  MAGISVVGRNNYGVFPLRGKLLNVREATHKQIMDNAEIQNIKQILGLQHGKEYDSVKSLR 528

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  HS WPSLLKIP+FL+EFITPI+KAT + G+VLSFY
Sbjct: 529  YGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHKNGKVLSFY 588

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            S+PEYE+WK  L GN SGWSIKYYKGLGTSTSKEGKEYF+DL KHKKDFLW+D +D DAI
Sbjct: 589  SMPEYESWKX-LGGNASGWSIKYYKGLGTSTSKEGKEYFKDLHKHKKDFLWVDDRDGDAI 647

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+A K WL+++EPGT LDQKEK IKYSDFV+KELI FS+ADL+RSIPSMVDG
Sbjct: 648  ELAFSKKKIEARKNWLRQFEPGTCLDQKEKLIKYSDFVNKELILFSMADLQRSIPSMVDG 707

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRN IKEAKVAQ SGYVSEHSAYHHGEQSL +TI+GMAQDY+GSNNI
Sbjct: 708  LKPGQRKILFCAFKRNLIKEAKVAQFSGYVSEHSAYHHGEQSLMSTIIGMAQDYVGSNNI 767

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NL QPNGQFGTRHQGGKDHASARYIYT LSPITRFLF K DD LL YLNEDGQS+EPTWY
Sbjct: 768  NLFQPNGQFGTRHQGGKDHASARYIYTRLSPITRFLFPKGDDILLDYLNEDGQSIEPTWY 827

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            +P+IP VLVNG+EGIGTGWS+YIPNYNPRDIVAN++  LN EPMEPM PWYKGFKG IE 
Sbjct: 828  MPIIPTVLVNGSEGIGTGWSSYIPNYNPRDIVANIKRLLNGEPMEPMDPWYKGFKGLIEK 887

Query: 1282 TNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKDF 1461
            T TK+AG SY V GIIEE+N+TT+RITELP+R+ T++YK+FL+ +++   + KE FIKD+
Sbjct: 888  TATKEAGSSYTVSGIIEEINETTLRITELPIRRWTQDYKEFLESIMTGNDKIKEPFIKDY 947

Query: 1462 REFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPEK 1641
            +E NDD TVHFEI +SE+NL MAK+EGL++KFKL+TTISTSNMHLF+PKG + KY +PE+
Sbjct: 948  KEHNDDTTVHFEIILSEENLMMAKQEGLMKKFKLTTTISTSNMHLFDPKGTIKKYDNPEQ 1007

Query: 1642 IIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDEL 1821
            I+EEF  LRLEFYEKRK   L           NKVRFI  V++G+II+ NRKR DL  EL
Sbjct: 1008 ILEEFFHLRLEFYEKRKKTQLDNLELDLLKLDNKVRFILGVVKGEIIVSNRKRVDLFLEL 1067

Query: 1822 KQK-------------------------------XXXXXXXXXXXXXXXXSMPIGTLTME 1908
            +QK                                               SM IGTLT+E
Sbjct: 1068 QQKGFTPFPKKTKALEAAVAGANEDGEENEENSEVVSSRGVRASDYEYLLSMAIGTLTLE 1127

Query: 1909 KVQELCAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQS-------------KIYD 2049
            KVQELC+ R KLN EV+ LR ATP SLW+ DLD+LE++L+ Q              K   
Sbjct: 1128 KVQELCSDRDKLNHEVEELRKATPNSLWMNDLDALEKELDEQDKNDAQAEEARKELKNRV 1187

Query: 2050 MPEKRLEVNAEISKRPKRTMRKKQESSEKKANNKDGLAEKHTVPSDCTGKVPEAVELEGI 2229
            M E  ++ + +  K P++T  KK  +SE    +    +    + +     VPE V+ +G 
Sbjct: 1188 MSEAGMKASRQAPKNPRKTNAKKPSTSETVTESVAASSVGSAMET-----VPEVVKPKG- 1241

Query: 2230 TTGRDEIS----TPNPPSLDVNEDR----GLEQKEEQPKQSSSPDTSREPKMSVLQVP-- 2379
              GR + +      N   +D +ED      L+++       SSP+ S   +  V +VP  
Sbjct: 1242 RGGRPKKAPAKKQDNMRLVDSDEDDVDVIELKERLAAYNLDSSPEQSAVMETEVAKVPAK 1301

Query: 2380 PEDNTRRNSADNLNAPIIEISDTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPS 2559
             ++ ++R +A    +   EISD     ++     +T+ E S  E+V              
Sbjct: 1302 KKEPSKRAAAQKQPSSYTEISD-----DDDGMDVQTIREESIGEIV-------------- 1342

Query: 2560 GDEKLEDQIASTVESGMTSVDKTSQENKNRHVMITRKRANMSRQNGATSLANGSSGSVLK 2739
             DE  E ++    + G       +     +    T+KR   ++Q     L       +LK
Sbjct: 1343 SDEDFEPEVEEAPKGGRGGRKPAA---NGKAAASTKKRGAANKQTSV--LGQKKITDLLK 1397

Query: 2740 AVENIMVSPEKKLRRTSSFPFRKK 2811
              EN  VSPEKK+R+  + PF KK
Sbjct: 1398 PAENAGVSPEKKVRKMRASPFNKK 1421


>ref|XP_002274267.1| PREDICTED: DNA topoisomerase 2 [Vitis vinifera]
          Length = 1489

 Score =  993 bits (2568), Expect = 0.0
 Identities = 550/993 (55%), Positives = 671/993 (67%), Gaps = 51/993 (5%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGR+ YGVFPLRGKLLNVR+A   QI  N EIQ+I +IL L+ GK Y+S++SLR
Sbjct: 465  MAGISVVGRNHYGVFPLRGKLLNVRDAQKKQILENAEIQNIKQILGLQQGKEYDSIKSLR 524

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  HS WPSLLKIP+FL+EFITPI+KAT R G+VLSFY
Sbjct: 525  YGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHRNGRVLSFY 584

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            S+PEYE+WK+SL GN SGWSIKYYKGLGTSTSKEGKEYF+DL KHKKDF+W+D+KD DAI
Sbjct: 585  SMPEYESWKESLGGNASGWSIKYYKGLGTSTSKEGKEYFKDLGKHKKDFMWVDEKDGDAI 644

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+  K WL++++PGTYLDQKEK IKYSDFV+KELI FS+ADL+RSIPSMVDG
Sbjct: 645  ELAFSKKKIEERKNWLRQFQPGTYLDQKEKLIKYSDFVNKELILFSMADLQRSIPSMVDG 704

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRNFIKEAK+AQ SGYVSEHSAYHHGEQSLA+TI+GMAQD++GSNNI
Sbjct: 705  LKPGQRKILFCSFKRNFIKEAKIAQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNI 764

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NLL PNGQFGTRHQGGKDHASARYIYT LSPITRFLF K+DD LL YLNEDGQS+EPTWY
Sbjct: 765  NLLLPNGQFGTRHQGGKDHASARYIYTRLSPITRFLFPKDDDILLDYLNEDGQSIEPTWY 824

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            VP IPMVLVNG+EGIGTGWS+ IPNYNPRDI+ANVR  LN E MEPM PWY+GF+GTIE 
Sbjct: 825  VPTIPMVLVNGSEGIGTGWSSSIPNYNPRDIIANVRRLLNGEMMEPMDPWYRGFRGTIEK 884

Query: 1282 TN-TKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKD 1458
            T+ TK     Y VKGIIEEVN+TT+RI+ELPVRK T++YK+FL+ +++   + K+ FIKD
Sbjct: 885  TDPTKQESVGYTVKGIIEEVNETTLRISELPVRKWTQDYKEFLESIMTGNDKIKDPFIKD 944

Query: 1459 FREFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPE 1638
            ++E NDD TVHFE+ MSE+NL MAK+EGL++KFKL+T ISTSNMHLF+  G + KY +PE
Sbjct: 945  YKEHNDDTTVHFEVIMSEENLLMAKQEGLLQKFKLTTKISTSNMHLFDSNGTIKKYETPE 1004

Query: 1639 KIIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDE 1818
            +I+EEF  LRLEFYEKRK  +L           NKVRFI  V++G+II+ NRKR+DL  E
Sbjct: 1005 QILEEFFHLRLEFYEKRKRVLLDNLELELLKLENKVRFILGVVRGEIIVSNRKRADLFHE 1064

Query: 1819 LKQK-------------------------------XXXXXXXXXXXXXXXXSMPIGTLTM 1905
            L QK                                               SM IGTLT+
Sbjct: 1065 LHQKGFTPFPKKSKSVEIAVAGATDDTEEAEENTDAVSKGGVRATDYEYLLSMAIGTLTL 1124

Query: 1906 EKVQELCAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYDMPEK-----RLE 2070
            EKVQELCA R KLN  VD L+ ATPK+LW+ DLD+LE++L+ Q K     E+     +  
Sbjct: 1125 EKVQELCADRDKLNKGVDDLKKATPKALWITDLDALERELDEQDKNDARAEETRKQLKSR 1184

Query: 2071 VNAEISKRPKRTMRKKQESSEKKANNKDGLAEKHTVPSDCT---GKVPEAVELEGITTGR 2241
            V +E   +  R   K    + KKANN +  AE   V +        VPE V+ +G    R
Sbjct: 1185 VMSEAGMKVSRQAPKNPRKNNKKANNAEPAAETMDVSASSAMEMESVPEVVKPKGRAAPR 1244

Query: 2242 ------DEISTPNPPSLDVNEDRGLEQKEEQPKQSSSPDTSREPKMSVLQVP---PEDNT 2394
                   E+ T      D +E   L+++       SSPD S   +  V QVP    ++ +
Sbjct: 1245 KAPAKKKEMPTSVLKDEDDDEVHELKERLAAYNLESSPDGSAAMEAEVPQVPAARKKEPS 1304

Query: 2395 RRNSADNLN-APIIEISDTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDEK 2571
            RR +A     A   EISD + D E+ +     V E+S S+V  +          P+ + K
Sbjct: 1305 RRAAAQKKPLASFTEISDDDEDDEDFE-----VEEVSASDVKKKGG------RKPAANAK 1353

Query: 2572 LEDQIASTVESGMTSVDKTSQENKNRHVMITRKRANMSRQNGATSLANGSSGSVLKAVEN 2751
                 A+   +   + +K    NK +  ++           G T L       + K  E 
Sbjct: 1354 ----AAAAKPAAAAAKNKRGAANKQQPQLL-----------GQTLLT-----EIFKPAET 1393

Query: 2752 IMVSPEKKLRRTSSFPFRKKKNYSPTKNGQNKE 2850
            + +SPEKK+R+  + PF KK        G+  E
Sbjct: 1394 LGISPEKKVRKMRASPFNKKSGSVLGSTGEEDE 1426


>emb|CDP07797.1| unnamed protein product [Coffea canephora]
          Length = 1486

 Score =  979 bits (2531), Expect = 0.0
 Identities = 540/981 (55%), Positives = 660/981 (67%), Gaps = 52/981 (5%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGR+ YGVFPLRGKLLNVREA++ QI  N EIQ I +IL L++GK Y+SV+SLR
Sbjct: 466  MAGISVVGRNFYGVFPLRGKLLNVREASHKQIMDNAEIQYIKQILGLQHGKVYDSVKSLR 525

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  HS WPSLLKIP+FL+EFITPI+KAT + G+VLSFY
Sbjct: 526  YGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHKNGRVLSFY 585

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            ++PEYE+WK+SL GN +GWSIKYYKGLGTSTSKEGKEYF+DL KHKKDF+W+D  D +AI
Sbjct: 586  TMPEYESWKESLSGNATGWSIKYYKGLGTSTSKEGKEYFKDLGKHKKDFIWVDDNDGEAI 645

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+A K WL+++EPGTYLDQKEK IKYSDF++KELI FS+ADL+RSIPSMVDG
Sbjct: 646  ELAFSKKKIEARKNWLRQFEPGTYLDQKEKLIKYSDFINKELILFSLADLQRSIPSMVDG 705

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRNF+KEAKVAQ SGYVSEHSAYHHGEQSLA+ I+GMAQD++GSNNI
Sbjct: 706  LKPGQRKILFCSFKRNFVKEAKVAQFSGYVSEHSAYHHGEQSLASAIIGMAQDFVGSNNI 765

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NLLQPNGQFGTR+QGGKDHASARY+YT LSPITR LF K+DD LL YLNEDGQS+EPTWY
Sbjct: 766  NLLQPNGQFGTRNQGGKDHASARYVYTRLSPITRSLFPKDDDILLDYLNEDGQSIEPTWY 825

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            +P+IPMVLVNG+EGIGTGWS+YIPNYNPRDI+ N+R  LN+EPMEPM PWYKGF+GTIE 
Sbjct: 826  MPIIPMVLVNGSEGIGTGWSSYIPNYNPRDIIGNIRRLLNNEPMEPMEPWYKGFRGTIEK 885

Query: 1282 TNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKDF 1461
            T TK+AG SY V GI+EEV++TT+R+TELPVRK T++YK+FL+ ++    + K+ FIK+F
Sbjct: 886  TATKEAGASYTVSGIVEEVDETTIRVTELPVRKWTQDYKEFLESIMMGNEKVKDPFIKEF 945

Query: 1462 REFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPEK 1641
            R+  DD TV+ +I MSE+NL MAK+EGL++KFKL+TTISTSNMHLF+ +G++ K+ +PE+
Sbjct: 946  RDHTDDTTVYLDIIMSEENLLMAKQEGLLKKFKLTTTISTSNMHLFDSQGIIKKFDNPEQ 1005

Query: 1642 IIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDEL 1821
            I+EEF  LRLEFYEKRK  +L           NKVRFI  V++G II+ NRKR+DL  EL
Sbjct: 1006 ILEEFFHLRLEFYEKRKKVLLDNLQLELLKLDNKVRFILAVVEGSIIVSNRKRADLFLEL 1065

Query: 1822 KQK------------------------------XXXXXXXXXXXXXXXXSMPIGTLTMEK 1911
            K+K                                              SM IG+LT+EK
Sbjct: 1066 KEKGFTPFPKKKSVEAAVAGSIEDAEETEESSEVATSKGVRASDYEYLISMAIGSLTLEK 1125

Query: 1912 VQELCAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYD------MPEKRLEV 2073
            VQELCA R KL  EVD L  ATPKSLW KDLD+LE +L+ Q  I D        E R + 
Sbjct: 1126 VQELCADRDKLKGEVDDLIKATPKSLWTKDLDALESQLDEQD-ISDAQAEAARKEMRSKA 1184

Query: 2074 NAEISKRPKRTMRKKQESSEKKANNKDGLAEKHTVPSDC---TGKVPEAVELEGITTGRD 2244
              +   +P R   K      KKA+N +   E   + S     T  V E  + +G   G  
Sbjct: 1185 MKDDGPKPTRQAPKNPRKYNKKASNTEPTTEPMEISSSSALETNNVVEVAKPKG-KAGPK 1243

Query: 2245 EISTPNPPSLDVNEDRGLEQKEE----------QPKQSSSPDTSREPKMSVLQVPPEDNT 2394
            +       +  V  D   E  +E              SSSPD S   +    ++P  + +
Sbjct: 1244 KAPARKGKTFSVLRDEDDEDDDEVLALKDRLAAYNLGSSSPDQSETME---TEIPKREPS 1300

Query: 2395 RRNSADNLNAPIIEISDTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDEKL 2574
            +R +       + EISD + D           IEISD E                 D +L
Sbjct: 1301 KRATTKKPLVSVTEISDDDDD----------QIEISDDE-----------------DFEL 1333

Query: 2575 EDQIASTVESGMTSVDKTSQENKNRHVMITRKR--ANMSRQNGATSLANGSSGSVLKAVE 2748
            E + A+  E G     KT+     +     +KR  AN + Q     L       VLK  +
Sbjct: 1334 EVE-AAPKEKGR---KKTANSKAAKPTAAPKKRGQANKTSQLVGQKLIT----EVLKPAD 1385

Query: 2749 NIMVSPEKKLRRTSSFPFRKK 2811
               +SPEKK+RR    PF KK
Sbjct: 1386 VSKISPEKKVRRMRPSPFNKK 1406


>ref|XP_009630917.1| PREDICTED: LOW QUALITY PROTEIN: DNA topoisomerase 2-like [Nicotiana
            tomentosiformis]
          Length = 1486

 Score =  972 bits (2512), Expect = 0.0
 Identities = 529/985 (53%), Positives = 675/985 (68%), Gaps = 48/985 (4%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGRD YGVFPLRGKLLNVREA++ Q+S N+EI++I KIL L+ GK Y SV+SLR
Sbjct: 461  MAGISVVGRDHYGVFPLRGKLLNVREASHKQVSENKEIEAIKKILGLQTGKEYESVKSLR 520

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  H+ WPSLLK+P+FL+EFITPI+KAT ++G++LSFY
Sbjct: 521  YGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLIEFITPIVKATHKSGKILSFY 580

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            ++PEYE+W++SL  N+SGWSIKYYKGLGTSTSKEGKEYFQDL+KH+KDF+W D +D ++I
Sbjct: 581  TMPEYESWRKSLGANSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADNQDGESI 640

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+A K WL+++EPGT+LDQKEK+I Y++FV+KELI FS+ADL+RSIPSM+DG
Sbjct: 641  ELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIPSMLDG 700

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRNF+KEAKV+Q SGYVSEHSAYHHGEQSL++TI+GMAQDY+GSNN+
Sbjct: 701  LKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYVGSNNV 760

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NLLQPNGQFGTR+ GGKDHAS+RYIYT LSPI RFLF K DD +L YLNEDGQ +EPTWY
Sbjct: 761  NLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKEDDTILDYLNEDGQYIEPTWY 820

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            VP++PMVL+NG+EGIGTGWS+Y+PNYNPRD+VANVR  LNDEPMEPM PWYKGFKGTIE 
Sbjct: 821  VPIVPMVLINGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDEPMEPMDPWYKGFKGTIEK 880

Query: 1282 TNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKDF 1461
            T TK+AG +Y V GIIEEVN+TT+RI+ELPVR+ TE+YKQFL+ +     + K+ FIK+ 
Sbjct: 881  TATKEAGATYTVTGIIEEVNETTLRISELPVRRWTEDYKQFLESMTVSNDKAKDPFIKEV 940

Query: 1462 REFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPEK 1641
            R + D+ +V FE+ MSE+NL +A++EGL++KFKL+TTISTSNMHLF+  G + KY +PE 
Sbjct: 941  RAYGDENSVCFEVIMSEENLILAQQEGLLKKFKLATTISTSNMHLFDSNGKIKKYDNPED 1000

Query: 1642 IIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDEL 1821
            I+EEF  +RLE+YEKRK  +L +         NKV+FI  V++G+II+ NRKR+DLL EL
Sbjct: 1001 ILEEFYHVRLEYYEKRKKALLEILELELLRIENKVKFILGVVKGEIIVNNRKRADLLLEL 1060

Query: 1822 KQK--------------------------XXXXXXXXXXXXXXXXSMPIGTLTMEKVQEL 1923
            K+K                                          SMPIGTLT+EKVQEL
Sbjct: 1061 KEKGFTPFPKKKAVEAVVADTSDDAEDSEEELNRGVRAGDYDYLLSMPIGTLTLEKVQEL 1120

Query: 1924 CAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYDMPE------KRLEVNAEI 2085
            CA+R KLN EV+ +R+ATPK LWLKDLD LE++L+ Q KI    E      K+  +NA  
Sbjct: 1121 CAERDKLNGEVEDMRNATPKLLWLKDLDVLEKQLDEQDKIDIQAEEAREKIKKKVMNAAG 1180

Query: 2086 SKRPKRTMRKKQESSEKKANNKDGLAEKHTVPSDCTGKVPEAVELEGITTGRDEISTPNP 2265
             K PK   RK    + KKA+  +  AE    P D          +    +G   +S  N 
Sbjct: 1181 LKAPKPKPRK----NVKKASVVESTAE----PMD---------XVSCFNSGNRLVSNSNV 1223

Query: 2266 PSLDVNEDRGLEQK-EEQPKQSSSPDTSREPKMSVLQVPPEDNTRRNSADNLNAP---II 2433
              +   + RG  +K   + K  +  D   E    VL +       R +A NLN+      
Sbjct: 1224 TEVVKPKARGGSKKAPAKAKPIAVEDEEEEEDDEVLALKD-----RLAAYNLNSSPDHSA 1278

Query: 2434 EISDTEV----------DCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDEKLEDQ 2583
            E  +TE               K++T  ++ ++S+     EDE+        S D++ E +
Sbjct: 1279 EAMETEAPKAQKKAPTRKAAAKKKTLPSIADVSEG----EDEI------EISDDDESEPE 1328

Query: 2584 IASTVESGMTSVDKTSQENKNRHVMITRKRANMSRQNGATSLANGSSGSVLKAVENI-MV 2760
            +A   +        T++          +KR   ++Q  A  +      S+LK  EN    
Sbjct: 1329 VAVGGKKKGGRKPATAKAAPAAAKQPPKKRGPANKQ--AVGIGQKLITSILKPAENTDNS 1386

Query: 2761 SPEKKLRRTSSFPFRKKKNYSPTKN 2835
            SPEKK+R+  + PF KK      KN
Sbjct: 1387 SPEKKVRKMRASPFNKKSGAVLGKN 1411


>ref|XP_009800897.1| PREDICTED: LOW QUALITY PROTEIN: DNA topoisomerase 2-like [Nicotiana
            sylvestris]
          Length = 1474

 Score =  971 bits (2511), Expect = 0.0
 Identities = 530/999 (53%), Positives = 683/999 (68%), Gaps = 49/999 (4%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGRD YGVFPLRGKLLNVREA++ Q+S N+EI++I KIL L+ GK Y+SV+SLR
Sbjct: 461  MAGISVVGRDHYGVFPLRGKLLNVREASHKQVSENKEIEAIKKILGLQTGKEYDSVKSLR 520

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  H+ WPSLLK+P+FL+EFITPI+KAT ++G++LSFY
Sbjct: 521  YGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLIEFITPIVKATHKSGKILSFY 580

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            ++PEYE+W++SL  N+SGWSIKYYKGLGTSTSKEGKEYFQDL+KH+KDF+W D +D ++I
Sbjct: 581  TMPEYESWRKSLGANSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADNQDGESI 640

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+A K WL+++EPGT+LDQKEK+I Y++FV+KELI FS+ADL+RSIPSM+DG
Sbjct: 641  ELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIPSMLDG 700

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRNF+KEAKV+Q SGYVSEHSAYHHGEQSL++TI+GMAQDY+GSNN+
Sbjct: 701  LKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYVGSNNV 760

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NLLQPNGQFGTR+ GGKDHAS+RYIYT LSPI RFLF K DD +L YLNEDGQS+EPTWY
Sbjct: 761  NLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKEDDTILDYLNEDGQSIEPTWY 820

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            VP++PMVL+NG+EGIGTGWS+Y+PNYNPRD+VANVR  LNDEPMEPM PWYKGFKGTIE 
Sbjct: 821  VPIVPMVLINGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDEPMEPMDPWYKGFKGTIEK 880

Query: 1282 TNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKDF 1461
            T TK+AG +Y V GIIEE+N+TT+RI+ELPVR+ TE+YKQFL+ +     + K+ FIK+ 
Sbjct: 881  TATKEAGATYTVTGIIEELNETTLRISELPVRRWTEDYKQFLESMTVSNDKAKDPFIKEV 940

Query: 1462 REFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPEK 1641
            R + D+ +V FE+ +SE+NL +A++EGL++KFKL+TTISTSNMHLF+ KG + KY +PE 
Sbjct: 941  RAYGDENSVCFEVILSEENLILAQQEGLLKKFKLATTISTSNMHLFDSKGKIKKYDNPED 1000

Query: 1642 IIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDEL 1821
            I+EEF  +RLE+YEKRK  +L +         NKV+FI  V++G+II+ NRKR+DLL EL
Sbjct: 1001 ILEEFYHVRLEYYEKRKRALLEILELELLRIENKVKFILGVVKGEIIVNNRKRADLLLEL 1060

Query: 1822 KQK--------------------------XXXXXXXXXXXXXXXXSMPIGTLTMEKVQEL 1923
            K+K                                          SM IGTLT+EKVQEL
Sbjct: 1061 KEKGFTPFPKKKAVEAVVADTSDDAEDSEEELNRGVRAGDYDYLLSMAIGTLTLEKVQEL 1120

Query: 1924 CAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYDMPE------KRLEVNAEI 2085
            CA+R KLN EV+ +R+ATPK LWLKDLD LE++L+ Q KI    E      K+  +NA  
Sbjct: 1121 CAERDKLNGEVEDMRNATPKLLWLKDLDVLEKQLDEQDKIDIQTEEAREKIKKKVMNAAG 1180

Query: 2086 SKRPKRTMRKKQESSEKKANNKDGLAEKHTVPSDCTGKVPEAVELEGITTGRDEISTPNP 2265
             K PK   RK    + KKA+  +  AE     S C  K            G   +S  N 
Sbjct: 1181 LKAPKPKPRK----NVKKASVVESTAEPMDXVS-CFNK------------GNRLVSNSNV 1223

Query: 2266 PSLDVNEDRGLEQKEEQPKQSSSPDTSREPKMSVLQVPPEDNTRRNSADNLN-------- 2421
              +   + RG  +K     +  + +   E    VL +       R +A NLN        
Sbjct: 1224 TEVVKPKARGGSKKAPAKAKPIAVEDEEEEDDEVLALKD-----RLAAYNLNSSPDHSTE 1278

Query: 2422 -----APIIEISDTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDEKLEDQI 2586
                 AP  +          K++T  ++ ++S+     EDE+        S D++ E ++
Sbjct: 1279 GMETEAPKAQKKAPTRKAAAKKKTLPSIADVSEG----EDEI------EISDDDEFEPEV 1328

Query: 2587 A--STVESGMTSVDKTSQENKNRHVMITRKRANMSRQNGATSLANGSSGSVLKAVENI-M 2757
            A     + G  +    +++         +KR   ++Q  +  +      S+LK  EN   
Sbjct: 1329 AVGGKKKGGRKAAPAATKQP-------PKKRGPGNKQ--SVGIGQKLITSILKPAENTDN 1379

Query: 2758 VSPEKKLRRTSSFPFRKKKNYSPTKNGQNKENYPSRCKE 2874
             SPEKK+R+  + PF KK   S +  G+NKE   S+  E
Sbjct: 1380 SSPEKKVRKMRASPFNKK---SGSVLGKNKEGSTSQENE 1415


>ref|XP_008779357.1| PREDICTED: DNA topoisomerase 2, partial [Phoenix dactylifera]
          Length = 1401

 Score =  970 bits (2507), Expect = 0.0
 Identities = 531/1000 (53%), Positives = 666/1000 (66%), Gaps = 50/1000 (5%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGR+ YGVFPLRGKLLNVREA++ QI  N EIQ+I +IL L++GK Y+S + LR
Sbjct: 392  MAGISVVGRNYYGVFPLRGKLLNVREASHKQIMENAEIQNIKQILGLQHGKEYDSTKGLR 451

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKATRAGQ--VLSF 378
            YGH+MIMTDQDHDGSHIKGLLIN  HS WPSLLKIP+F++EFITPI+KAT +    VL F
Sbjct: 452  YGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFMVEFITPIVKATHSKNKTVLPF 511

Query: 379  YSIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDA 558
            YS+PEYEAWK+ L GN SGWSIKYYKGLGTSTSKEGKEYF D++KHKKDF+W+D +D DA
Sbjct: 512  YSMPEYEAWKERLGGNASGWSIKYYKGLGTSTSKEGKEYFHDIDKHKKDFIWVDDQDGDA 571

Query: 559  IELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVD 738
            IELAFSK KI+A K WL+ +E GTYLDQ++KHIKYSDFV+KELI FS+ADL+RSIPS VD
Sbjct: 572  IELAFSKKKIEARKNWLRHFETGTYLDQRQKHIKYSDFVNKELILFSMADLQRSIPSTVD 631

Query: 739  GFKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNN 918
            G KPGQRKILF  FKRNF+KEAKVAQ SGYVSEHSAYHHGEQSLA+TI+GMAQD++GSNN
Sbjct: 632  GLKPGQRKILFCSFKRNFVKEAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNN 691

Query: 919  INLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTW 1098
            INLLQPNGQFGTRHQGGKDHASARYIYT LSP+TRFLF K+DD LL YLNEDGQS+EPTW
Sbjct: 692  INLLQPNGQFGTRHQGGKDHASARYIYTRLSPLTRFLFPKDDDMLLDYLNEDGQSIEPTW 751

Query: 1099 YVPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIE 1278
            Y+P+IP+VLVNG+EGIGTGWS+++PNYNPRDIVANVR  LNDEPM+PM PWY+GFKG IE
Sbjct: 752  YMPIIPLVLVNGSEGIGTGWSSFVPNYNPRDIVANVRRLLNDEPMQPMDPWYRGFKGLIE 811

Query: 1279 STNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKD 1458
             + TK+AG +Y + G+IEEV+ TT+RITELP+R+ T++YK+FL+ +++   + KE FIKD
Sbjct: 812  KSATKEAGVTYTITGLIEEVDSTTLRITELPIRRWTQDYKEFLESMMTGNDKIKEPFIKD 871

Query: 1459 FREFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPE 1638
            +RE NDD  VHFEI ++E+ L MAKEEGL  KFKL+TTIST+NMHLF+ +GV+ KY +PE
Sbjct: 872  YREHNDDINVHFEIILTEEKLKMAKEEGLERKFKLTTTISTTNMHLFDSEGVIKKYDTPE 931

Query: 1639 KIIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDE 1818
            +I+E+F  LRLE+Y KRK  +L           NKVRFI  V++G+II+ NRKR+DL  E
Sbjct: 932  QILEDFFHLRLEYYAKRKKVLLDNLEMDLLKLDNKVRFILGVVRGEIIVSNRKRADLFLE 991

Query: 1819 LKQK--------------------------XXXXXXXXXXXXXXXXSMPIGTLTMEKVQE 1920
            L+QK                                          SM IGTLT EKVQE
Sbjct: 992  LQQKGFTPFPKKSKGIDAAIAGATEEDDNEESPEVAARATDYEYLLSMAIGTLTWEKVQE 1051

Query: 1921 LCAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYDMPEKRLEVNAEISKRPK 2100
            LCA RKKL  EV+ L+ ++P+ LW+KDLD  E++L+      ++  K  E   E  KR  
Sbjct: 1052 LCADRKKLEGEVEELKKSSPRDLWMKDLDDFERELD------ELERKDAE---EGMKRET 1102

Query: 2101 RTMR------KKQESSEKKANNKDGLAEKHTVPSDCTGKVPEAVELEGITTGRDEISTPN 2262
            RT         +Q   + + NN +  +    V S   G  PE  +L+    G  +     
Sbjct: 1103 RTKNITGAAVSRQGPKKPRKNNANNSSSISNVTSTDAGNAPEPSKLKA-RGGAKKAPAKK 1161

Query: 2263 PPSLDVNEDR---GLEQKEEQPKQSSSPDTS---REPKMSVLQVPPEDNTRRNSADNLNA 2424
               ++ +ED     L+ +       SSPD S    E  +S  +   ++ ++R +      
Sbjct: 1162 VMVVESDEDEEVLALKDRLAAYNLDSSPDQSAMEAEAALSQREHRKKEPSKRTAL----- 1216

Query: 2425 PIIEISDTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDEKLEDQIASTVES 2604
                           ++   T  EISD + V ED +P   I     DE  E  +A   + 
Sbjct: 1217 ---------------RKAPSTFTEISDGDDV-EDNMP---IVGEDDDEDFE--LAEAPKG 1255

Query: 2605 GMTSVDKTSQENKNRHVMITRKRANMSRQNGATSLANGSSGSVLKAVENIMVSPEKKLRR 2784
            G     K + E   R    T  R   + Q+    L+      VLK VEN  +SP+KK+R+
Sbjct: 1256 GQARGRKPANEKAKRGKATTTTRKRGAAQSKPV-LSQKLITEVLKPVENAGISPDKKVRK 1314

Query: 2785 TSSFPFRKKK-------NYSPT---KNGQNKENYPSRCKE 2874
              + PF KK          SPT   ++G +    P+   E
Sbjct: 1315 MRASPFNKKSGPVLGRTGSSPTDSEESGSHSSGSPAEMNE 1354


>ref|XP_015163346.1| PREDICTED: DNA topoisomerase 2 isoform X1 [Solanum tuberosum]
          Length = 1487

 Score =  969 bits (2504), Expect = 0.0
 Identities = 523/1002 (52%), Positives = 675/1002 (67%), Gaps = 39/1002 (3%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGRD YGVFPLRGKLLNVREA++ Q+S N+EI+SI KIL L+ GK Y SV+SLR
Sbjct: 462  MAGISVVGRDHYGVFPLRGKLLNVREASHKQVSENKEIESIKKILGLQTGKEYESVKSLR 521

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  H+ WPSLLK+P+FL+EFITPI+KAT ++G++L+FY
Sbjct: 522  YGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSGRILAFY 581

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            ++PEYEAW++SL   +SGWSIKYYKGLGTSTSKEGKEYFQDL+KH+KDF+W D +D ++I
Sbjct: 582  TMPEYEAWRRSLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADNQDGESI 641

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+A K WL+++EPGT+LDQKEK+I Y++FV+KELI FS+ADL+RSIPSM+DG
Sbjct: 642  ELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIPSMLDG 701

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRNF+KEAKV+Q SGYVSEHSAYHHGEQSL++TI+GMAQDY+GSNN+
Sbjct: 702  LKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYVGSNNV 761

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NLLQPNGQFGTR+ GGKDHAS+RYIYT LSPI RFLF K+DD +L YLNEDGQS+EPTWY
Sbjct: 762  NLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTVLDYLNEDGQSIEPTWY 821

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            +P+IPMVLVNG+EGIGTGWS+Y+PNYNPRD+VANVR  LNDE MEPM PWYKGFKGTIE 
Sbjct: 822  IPIIPMVLVNGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGFKGTIEK 881

Query: 1282 TNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKDF 1461
            T TK+ G +Y V GIIEE ++TT+RI+ELPVR+ TE+YKQFL+ +     ++K+ FIK+ 
Sbjct: 882  TATKETGATYTVTGIIEEFSETTLRISELPVRRWTEDYKQFLESMTVSTDKSKDAFIKEV 941

Query: 1462 REFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPEK 1641
            R + D+ +V FE+ MSE+NL +A++EGL++KFKL+TTISTSNMHLF+ KG + KY +PE+
Sbjct: 942  RAYGDENSVCFEVIMSEENLLLAQQEGLLKKFKLTTTISTSNMHLFDSKGKIKKYDAPEE 1001

Query: 1642 IIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDEL 1821
            I+EEF  +RLE+YEKRK  +L +         NKVRFI  V++G+II+ NRKR+DLL EL
Sbjct: 1002 ILEEFYHVRLEYYEKRKKTLLEILELELLRIENKVRFILGVVKGEIIVNNRKRADLLLEL 1061

Query: 1822 KQK-----------------------------XXXXXXXXXXXXXXXXSMPIGTLTMEKV 1914
            K K                                             SM IGTLT+EKV
Sbjct: 1062 KNKGFTPFPKKKPVEAVVADSTDDAEDSEESPEESNKGVRASDYDYLLSMAIGTLTLEKV 1121

Query: 1915 QELCAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYDMPEKRLEVNAEISKR 2094
            QELCA R KLN EV+ +R+ATPK LW+KDLD L+++L+ Q K+    E   E   ++ K+
Sbjct: 1122 QELCADRDKLNAEVEDMRNATPKDLWMKDLDVLDKQLDEQDKLDIQTE---EAREKLKKK 1178

Query: 2095 PKRTMRKKQESSEKKANNKDGLAEKHTVPSDCTGKVPEAVELEGITTGRDEISTPNPPSL 2274
                  K  +   +K   K  + E    P D +  V    E   +T    E++ P     
Sbjct: 1179 VMNAAGKAPKPKPRKTTKKAAVVESTAEPMDVS--VGSMAETANVT----EVAKP----- 1227

Query: 2275 DVNEDRGLEQKEEQPKQSSSP----DTSREPKMSVLQVPPEDNTRRNSADNLNAPIIEIS 2442
               + RG   K+   KQ + P    D   E ++  L+        R +A NLN+      
Sbjct: 1228 ---KGRGGGSKKAPAKQQAKPVVVEDEEEEDEVLALK-------DRLAAYNLNSSPDRSE 1277

Query: 2443 DTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDE-KLEDQIASTVESGMTSV 2619
             TE +    Q  A      +  +      +P+T   +   DE ++ D      E  +   
Sbjct: 1278 VTETEAPKAQTKAPAKRAAAQKKA-----LPSTPDVSEGEDEIEISDDNEFAPEVAVGGK 1332

Query: 2620 DKTSQENKNRHVMIT----RKRANMSRQNGATSLANGSSGSVLKAVENIMVSPEKKLRRT 2787
             K  ++             +KRA  ++Q  + S+       VLK  E+  VSP++K+R+ 
Sbjct: 1333 KKGGRKPAAAKAAAAPKPPKKRAPANKQ--SQSVGQRLITQVLKPAEDAGVSPDRKVRKM 1390

Query: 2788 SSFPFRKKKNYSPTKNGQNKENYPSRCKESNLRNTV*LIASL 2913
               PF KK   S    G+N  +  S   ES +   +  + SL
Sbjct: 1391 RESPFNKK---SGAVMGRNTSSSSSTSHESEVSPPIPSLGSL 1429


>ref|XP_010023678.1| PREDICTED: DNA topoisomerase 2-like [Eucalyptus grandis]
            gi|629094018|gb|KCW60013.1| hypothetical protein
            EUGRSUZ_H02748 [Eucalyptus grandis]
          Length = 1496

 Score =  968 bits (2503), Expect = 0.0
 Identities = 525/983 (53%), Positives = 668/983 (67%), Gaps = 44/983 (4%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAG+S VGRD YGVFPLRGKLLNVREA++ QI  N+EIQ I +IL L+  K+Y+SV+SLR
Sbjct: 482  MAGLSVVGRDRYGVFPLRGKLLNVREASHSQIMENKEIQYIKQILGLQQNKDYDSVKSLR 541

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  HS WPSLLK+P+FL+EFITPI+KAT + G+ LSFY
Sbjct: 542  YGHLMIMTDQDHDGSHIKGLLINFVHSFWPSLLKVPSFLVEFITPIVKATHKNGRELSFY 601

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            ++PEYE+WK+SL G+ SGWSIKYYKGLGTSTSKEGK+YFQ+L+ HKKDF+W+D +D DAI
Sbjct: 602  TMPEYESWKESLGGSGSGWSIKYYKGLGTSTSKEGKQYFQNLDMHKKDFVWVDDQDGDAI 661

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+A K WL+++EPGTYLDQKEK IKYSDFV+KELI FS+ADL+RSIPSMVDG
Sbjct: 662  ELAFSKKKIEARKTWLRQFEPGTYLDQKEKLIKYSDFVNKELILFSMADLQRSIPSMVDG 721

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRNFIKEAKVAQ SGYVSEHSAYHHGEQSLA+TI+GMAQDY+GSNNI
Sbjct: 722  LKPGQRKILFCSFKRNFIKEAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQDYVGSNNI 781

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NLL PNGQFGTR+ GGKDHAS RY+YT LSP TRFLF K+DD LL YLNEDGQS+EPTWY
Sbjct: 782  NLLMPNGQFGTRNMGGKDHASPRYVYTKLSPTTRFLFPKDDDNLLSYLNEDGQSIEPTWY 841

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            +P++PMVLVNG+EGIGTGWS+YIPNYNPRDI+AN+R  LN E MEPM PWY+GF+GTIE 
Sbjct: 842  MPILPMVLVNGSEGIGTGWSSYIPNYNPRDIIANLRRLLNGEMMEPMDPWYRGFRGTIEK 901

Query: 1282 TNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLIS-KGGRNKEQFIKD 1458
            T TK+AG +Y V GIIEEV+ TT+RITELP+R+ T++Y++FL+ L + +  + K+ F+K+
Sbjct: 902  TATKEAGVTYTVCGIIEEVDDTTLRITELPIRRWTQDYREFLESLSTGEKDKAKDPFVKE 961

Query: 1459 FREFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPE 1638
            FR+++DD TVHFE+ ++E+N+ +AK+EGL++KFKL+++ISTSNMHLF+P GV+ KY SPE
Sbjct: 962  FRQYSDDVTVHFEVMLTEENMMIAKQEGLLKKFKLTSSISTSNMHLFDPNGVIKKYDSPE 1021

Query: 1639 KIIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDE 1818
            +I+EEF  LRLE YEKRK  +L           NKVRFI  V+ G+II+ NRKR+DL  E
Sbjct: 1022 QILEEFFHLRLECYEKRKKILLENLELKLVMLDNKVRFILGVVHGEIIVSNRKRADLFQE 1081

Query: 1819 LKQKXXXXXXXXXXXXXXXX------------------------------SMPIGTLTME 1908
            L+ K                                              SM IG LT+E
Sbjct: 1082 LQAKGFTPFRKETKTIETAVAGSTDDAEETEENSEPTTKGVKASDYEYLLSMAIGALTLE 1141

Query: 1909 KVQELCAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYDMPEKRLEVNAE-- 2082
            KVQELCA + KL  EVD LR ATP++LWL+DL +LE+KL+ Q K+    E+  +  ++  
Sbjct: 1142 KVQELCADKDKLVDEVDALRKATPENLWLEDLAALEEKLDEQEKMDAQAEETRKARSKAN 1201

Query: 2083 -ISKRPKRTMRKKQESSEKKANNKDGLAEKHTVPSDCTGKVPEAVELEGITTGRDEISTP 2259
             +  +  R   KK   ++ KANN +  AE  T  S  T +   A ++     G      P
Sbjct: 1202 GVGTKVSRQAPKKPRKNDTKANNPEAQAEV-TQGSTVTLEAGNAADVAKPKRGAGARKAP 1260

Query: 2260 NP---PSLDVNED------RGLEQKEEQPKQSSSPDTSREPKMSVLQVPPEDNTRRNSAD 2412
             P    S  V++D        L+++       SSPD S   +  V ++P ++      A 
Sbjct: 1261 APKPSKSASVSDDDEDFEMLDLKERLAAYNLESSPDNSSALEDKVPEIPVKEKEPSKRAA 1320

Query: 2413 NLNAPIIEISDTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDEKLEDQIAS 2592
                P + +S+   + EN   + +   E  DSE           +    G  K     A+
Sbjct: 1321 TRKKPSVILSEISEE-ENSNDSGDDDYETVDSE---------AEVAKKKGGRK---PSAA 1367

Query: 2593 TVESGMTSVDKTSQENKNRHVMITRKRANMSRQNGATSLANGSSGSVLKAVENIMVSPEK 2772
              +S   +  K  Q N        R++A  + Q   T +        LK  E+  VSPEK
Sbjct: 1368 AKKSKPPAATKKGQAN--------RQQARGTSQRLLTEM--------LKPAESTGVSPEK 1411

Query: 2773 KLRRTSSFPFRKKKNYSPTKNGQ 2841
            K+R+  + PF KK +    K G+
Sbjct: 1412 KVRKMRASPFNKKSSSLLGKEGK 1434


>ref|XP_010920068.1| PREDICTED: DNA topoisomerase 2 [Elaeis guineensis]
          Length = 1486

 Score =  968 bits (2502), Expect = 0.0
 Identities = 534/1005 (53%), Positives = 664/1005 (66%), Gaps = 53/1005 (5%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGR+ YGVFPLRGKLLNVREA++ QI  N EIQSI +IL L+ GK Y S + LR
Sbjct: 471  MAGISVVGRNHYGVFPLRGKLLNVREASHKQIMDNAEIQSIKQILGLQQGKEYESTKGLR 530

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT--RAGQVLSF 378
            YGH+MIMTDQDHDGSHIKGLLIN  HS WPSLLKIP+F++EFITPI+KAT  R   VL F
Sbjct: 531  YGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPSFMVEFITPIVKATHNRNKNVLPF 590

Query: 379  YSIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDA 558
            YS+PEYEAWK+SL GN SGWSIKYYKGLGTSTSKEGKEYFQD+ KHKKDF+W+D +D DA
Sbjct: 591  YSMPEYEAWKESLGGNASGWSIKYYKGLGTSTSKEGKEYFQDIVKHKKDFMWVDNQDGDA 650

Query: 559  IELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVD 738
            IELAFSK KI+A K WL+++EPGTYLDQ+EK IKYSDFV+KELI FS+ADL+RSIPSMVD
Sbjct: 651  IELAFSKKKIEARKNWLRQFEPGTYLDQREKLIKYSDFVNKELILFSMADLQRSIPSMVD 710

Query: 739  GFKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNN 918
            G KPGQRKILF  FKRNF+KEAKVAQ +GYVSEHSAYHHGEQSLA+TI+GMAQD++GSNN
Sbjct: 711  GLKPGQRKILFCSFKRNFVKEAKVAQFAGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNN 770

Query: 919  INLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTW 1098
            INLLQPNGQFGTRHQGGKDHASARYIYT LSP+TRFLF K+DD LL YLNEDGQ +EPTW
Sbjct: 771  INLLQPNGQFGTRHQGGKDHASARYIYTRLSPLTRFLFPKDDDILLDYLNEDGQLIEPTW 830

Query: 1099 YVPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIE 1278
            Y+P+IPMVLVNG+EGIGTGWST++PNYNPRDIVANVR  LN+EPM+PM PWY+ FKG IE
Sbjct: 831  YMPIIPMVLVNGSEGIGTGWSTFVPNYNPRDIVANVRRLLNNEPMQPMDPWYRSFKGLIE 890

Query: 1279 STNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKD 1458
             + +K+AG +Y + G+ EEV+ TT++ITELP+R+ T++YK+FL+ L++   + KE FIKD
Sbjct: 891  KSASKEAGVTYTITGLAEEVDSTTLKITELPIRRWTQDYKEFLESLMTGNDKIKEPFIKD 950

Query: 1459 FREFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPE 1638
            +RE NDD  VHFEI ++E+ L MA+EEGL +KFKL+TTIST+NMHLF+ KGV+ KY +PE
Sbjct: 951  YREQNDDVNVHFEIILTEEKLNMAREEGLEKKFKLTTTISTTNMHLFDSKGVIKKYDTPE 1010

Query: 1639 KIIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDE 1818
            +I+E+F  LRLEFY KRK  +L           NKVRFI  V++G+II+ NRKR+DL  E
Sbjct: 1011 QILEDFFHLRLEFYAKRKKALLDNLELDLLKLDNKVRFILGVVRGEIIVNNRKRADLFLE 1070

Query: 1819 LKQK-------------------------------XXXXXXXXXXXXXXXXSMPIGTLTM 1905
            L+QK                                               SM IGTLT 
Sbjct: 1071 LQQKGFAPFPKKSKGIDAAIAGATVEEDGNEESPEVVNGGGARAADYEYLLSMAIGTLTW 1130

Query: 1906 EKVQELCAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYDMPEKRLEVNAEI 2085
            EKVQELCA+RKKL  EV+ LR ++P+ LW+KDLD+ E +L+ Q +      K  E   + 
Sbjct: 1131 EKVQELCAERKKLEDEVEELRKSSPRDLWMKDLDAFEMELDEQER------KDAEEGIKR 1184

Query: 2086 SKRPKR---TMRKKQESSEKKANNKDGLAEKHTVPSDCTGKVPEAVELEGITTGR----- 2241
              R K        KQ   + + NN +  +    V S   G  PEA + +    GR     
Sbjct: 1185 ETRMKNITGAALSKQGPKKPRKNNANNSSTVSDVTSTDAGNAPEASKPK--PRGRAKKAP 1242

Query: 2242 -DEISTPNPPSLDVNEDRGLEQKEEQPKQSSSPD----TSREPKMSVLQVPPEDNTRRNS 2406
              +++       D  E   L+ +       SSPD       E  +S  +   ++ ++R +
Sbjct: 1243 AKKVAVVESDEDDEEEVLALKDRLAAYNLDSSPDHQSAMETEAVLSQKEQRKKEPSKRTA 1302

Query: 2407 ADNLNAPIIEISDTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDEKLEDQI 2586
            A    +   EISD     ++ +    T++E  D E     E P      P G +    + 
Sbjct: 1303 ARKAPSTFTEISDG----DDAEDDMPTILEDDDDEDFELVEAP------PKGGKARGKKP 1352

Query: 2587 ASTVESGMTSVDKTSQENKNRHVMITRKRANMSRQNGATSLANGSSGSVLKAVENIMVSP 2766
            A+    G  +   T           TRKR     +     L+      VLK VEN  +SP
Sbjct: 1353 ANEKAKGGKAGTTT-----------TRKRGTAQSK---PVLSQKLITEVLKPVENTGISP 1398

Query: 2767 EKKLRRTSSFPFRKKK-------NYSPTKNGQNKENYPSRCKESN 2880
            EKK+R+  + PF KK          SPT + ++  + P    E N
Sbjct: 1399 EKKVRKMRASPFNKKSGSVLGRIGSSPTSSEESGSSSPGNPAELN 1443


>ref|XP_015163347.1| PREDICTED: DNA topoisomerase 2 isoform X2 [Solanum tuberosum]
          Length = 1486

 Score =  966 bits (2496), Expect = 0.0
 Identities = 522/1001 (52%), Positives = 674/1001 (67%), Gaps = 38/1001 (3%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGRD YGVFPLRGKLLNVREA++ Q+S N+EI+SI KIL L+ GK Y SV+SLR
Sbjct: 462  MAGISVVGRDHYGVFPLRGKLLNVREASHKQVSENKEIESIKKILGLQTGKEYESVKSLR 521

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  H+ WPSLLK+P+FL+EFITPI+KAT ++G++L+FY
Sbjct: 522  YGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSGRILAFY 581

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            ++PEYEAW++SL   +SGWSIKYYKGLGTSTSKEGKEYFQDL+KH+KDF+W D +D ++I
Sbjct: 582  TMPEYEAWRRSLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADNQDGESI 641

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+A K WL+++EPGT+LDQKEK+I Y++FV+KELI FS+ADL+RSIPSM+DG
Sbjct: 642  ELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIPSMLDG 701

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRNF+KEAKV+Q SGYVSEHSAYHHGEQSL++TI+GMAQDY+GSNN+
Sbjct: 702  LKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYVGSNNV 761

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NLLQPNGQFGTR+ GGKDHAS+RYIYT LSPI RFLF K+DD +L YLNEDGQS+EPTWY
Sbjct: 762  NLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTVLDYLNEDGQSIEPTWY 821

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            +P+IPMVLVNG+EGIGTGWS+Y+PNYNPRD+VANVR  LNDE MEPM PWYKGFKGTIE 
Sbjct: 822  IPIIPMVLVNGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGFKGTIEK 881

Query: 1282 TNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKDF 1461
            T TK+ G +Y V GIIEE ++TT+RI+ELPVR+ TE+YKQFL+ +     ++K+ FIK+ 
Sbjct: 882  TATKETGATYTVTGIIEEFSETTLRISELPVRRWTEDYKQFLESMTVSTDKSKDAFIKEV 941

Query: 1462 REFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPEK 1641
            R + D+ +V FE+ MSE+NL +A++EGL++KFKL+TTISTSNMHLF+ KG + KY +PE+
Sbjct: 942  RAYGDENSVCFEVIMSEENLLLAQQEGLLKKFKLTTTISTSNMHLFDSKGKIKKYDAPEE 1001

Query: 1642 IIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDEL 1821
            I+EEF  +RLE+YEKRK  +L +         NKVRFI  V++G+II+ NRKR+DLL EL
Sbjct: 1002 ILEEFYHVRLEYYEKRKKTLLEILELELLRIENKVRFILGVVKGEIIVNNRKRADLLLEL 1061

Query: 1822 KQK-----------------------------XXXXXXXXXXXXXXXXSMPIGTLTMEKV 1914
            K K                                             SM IGTLT+EKV
Sbjct: 1062 KNKGFTPFPKKKPVEAVVADSTDDAEDSEESPEESNKGVRASDYDYLLSMAIGTLTLEKV 1121

Query: 1915 QELCAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYDMPEKRLEVNAEISKR 2094
            QELCA R KLN EV+ +R+ATPK LW+KDLD L+++L+ Q K+    E   E   ++ K+
Sbjct: 1122 QELCADRDKLNAEVEDMRNATPKDLWMKDLDVLDKQLDEQDKLDIQTE---EAREKLKKK 1178

Query: 2095 PKRTMRKKQESSEKKANNKDGLAEKHTVPSDCTGKVPEAVELEGITTGRDEISTPNPPSL 2274
                  K  +   +K   K  + E    P D +  V    E   +T    E++ P     
Sbjct: 1179 VMNAAGKAPKPKPRKTTKKAAVVESTAEPMDVS--VGSMAETANVT----EVAKP----- 1227

Query: 2275 DVNEDRGLEQKEEQPKQSSS---PDTSREPKMSVLQVPPEDNTRRNSADNLNAPIIEISD 2445
               + RG   K+   KQ+      D   E ++  L+        R +A NLN+       
Sbjct: 1228 ---KGRGGGSKKAPAKQAKPVVVEDEEEEDEVLALK-------DRLAAYNLNSSPDRSEV 1277

Query: 2446 TEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDE-KLEDQIASTVESGMTSVD 2622
            TE +    Q  A      +  +      +P+T   +   DE ++ D      E  +    
Sbjct: 1278 TETEAPKAQTKAPAKRAAAQKKA-----LPSTPDVSEGEDEIEISDDNEFAPEVAVGGKK 1332

Query: 2623 KTSQENKNRHVMIT----RKRANMSRQNGATSLANGSSGSVLKAVENIMVSPEKKLRRTS 2790
            K  ++             +KRA  ++Q  + S+       VLK  E+  VSP++K+R+  
Sbjct: 1333 KGGRKPAAAKAAAAPKPPKKRAPANKQ--SQSVGQRLITQVLKPAEDAGVSPDRKVRKMR 1390

Query: 2791 SFPFRKKKNYSPTKNGQNKENYPSRCKESNLRNTV*LIASL 2913
              PF KK   S    G+N  +  S   ES +   +  + SL
Sbjct: 1391 ESPFNKK---SGAVMGRNTSSSSSTSHESEVSPPIPSLGSL 1428


>ref|XP_006345427.1| PREDICTED: DNA topoisomerase 2 isoform X3 [Solanum tuberosum]
          Length = 1485

 Score =  965 bits (2495), Expect = 0.0
 Identities = 522/1005 (51%), Positives = 671/1005 (66%), Gaps = 42/1005 (4%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGRD YGVFPLRGKLLNVREA++ Q+S N+EI+SI KIL L+ GK Y SV+SLR
Sbjct: 462  MAGISVVGRDHYGVFPLRGKLLNVREASHKQVSENKEIESIKKILGLQTGKEYESVKSLR 521

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  H+ WPSLLK+P+FL+EFITPI+KAT ++G++L+FY
Sbjct: 522  YGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSGRILAFY 581

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            ++PEYEAW++SL   +SGWSIKYYKGLGTSTSKEGKEYFQDL+KH+KDF+W D +D ++I
Sbjct: 582  TMPEYEAWRRSLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADNQDGESI 641

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+A K WL+++EPGT+LDQKEK+I Y++FV+KELI FS+ADL+RSIPSM+DG
Sbjct: 642  ELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIPSMLDG 701

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRNF+KEAKV+Q SGYVSEHSAYHHGEQSL++TI+GMAQDY+GSNN+
Sbjct: 702  LKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYVGSNNV 761

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NLLQPNGQFGTR+ GGKDHAS+RYIYT LSPI RFLF K+DD +L YLNEDGQS+EPTWY
Sbjct: 762  NLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTVLDYLNEDGQSIEPTWY 821

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            +P+IPMVLVNG+EGIGTGWS+Y+PNYNPRD+VANVR  LNDE MEPM PWYKGFKGTIE 
Sbjct: 822  IPIIPMVLVNGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGFKGTIEK 881

Query: 1282 TNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKDF 1461
            T TK+ G +Y V GIIEE ++TT+RI+ELPVR+ TE+YKQFL+ +     ++K+ FIK+ 
Sbjct: 882  TATKETGATYTVTGIIEEFSETTLRISELPVRRWTEDYKQFLESMTVSTDKSKDAFIKEV 941

Query: 1462 REFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPEK 1641
            R + D+ +V FE+ MSE+NL +A++EGL++KFKL+TTISTSNMHLF+ KG + KY +PE+
Sbjct: 942  RAYGDENSVCFEVIMSEENLLLAQQEGLLKKFKLTTTISTSNMHLFDSKGKIKKYDAPEE 1001

Query: 1642 IIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDEL 1821
            I+EEF  +RLE+YEKRK  +L +         NKVRFI  V++G+II+ NRKR+DLL EL
Sbjct: 1002 ILEEFYHVRLEYYEKRKKTLLEILELELLRIENKVRFILGVVKGEIIVNNRKRADLLLEL 1061

Query: 1822 KQK-----------------------------XXXXXXXXXXXXXXXXSMPIGTLTMEKV 1914
            K K                                             SM IGTLT+EKV
Sbjct: 1062 KNKGFTPFPKKKPVEAVVADSTDDAEDSEESPEESNKGVRASDYDYLLSMAIGTLTLEKV 1121

Query: 1915 QELCAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYDMPEKRLEVNAEISKR 2094
            QELCA R KLN EV+ +R+ATPK LW+KDLD L+++L+ Q K+    E   E   ++ K+
Sbjct: 1122 QELCADRDKLNAEVEDMRNATPKDLWMKDLDVLDKQLDEQDKLDIQTE---EAREKLKKK 1178

Query: 2095 PKRTMRKKQESSEKKANNKDGLAEKHTVPSDC-------TGKVPEAVELEGITTGRDEIS 2253
                  K  +   +K   K  + E    P D        T  V E  + +G   G  +  
Sbjct: 1179 VMNAAGKAPKPKPRKTTKKAAVVESTAEPMDVSVGSMAETANVTEVAKPKGRGGGSKKAP 1238

Query: 2254 TPNPPSLDVNEDR-----GLEQKEEQPKQSSSPDTSREPKMSVLQVPPEDNTRRNSADNL 2418
                P +  +E+       L+ +      +SSPD S   +    +   +   +R +A   
Sbjct: 1239 AKAKPVVVEDEEEEDEVLALKDRLAAYNLNSSPDRSEVTETEAPKAQTKAPAKRAAAQKK 1298

Query: 2419 NAPIIEISDTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDEKLEDQIASTV 2598
              P    S  +V         E  IEISD      +  P   +    G +K   + A+  
Sbjct: 1299 ALP----STPDV------SEGEDEIEISDD----NEFAPEVAV---GGKKKGGRKPAAAK 1341

Query: 2599 ESGMTSVDKTSQENKNRHVMITRKRANMSRQNGATSLANGSSGSVLKAVENIMVSPEKKL 2778
             +      K              KRA  ++Q  + S+       VLK  E+  VSP++K+
Sbjct: 1342 AAAAPKPPK--------------KRAPANKQ--SQSVGQRLITQVLKPAEDAGVSPDRKV 1385

Query: 2779 RRTSSFPFRKKKNYSPTKNGQNKENYPSRCKESNLRNTV*LIASL 2913
            R+    PF KK   S    G+N  +  S   ES +   +  + SL
Sbjct: 1386 RKMRESPFNKK---SGAVMGRNTSSSSSTSHESEVSPPIPSLGSL 1427


>gb|AAN85207.1| DNA topoisomerase II [Nicotiana tabacum] gi|26984168|gb|AAN85208.1|
            DNA topoisomerase II [Nicotiana tabacum]
          Length = 1482

 Score =  964 bits (2493), Expect = 0.0
 Identities = 515/977 (52%), Positives = 666/977 (68%), Gaps = 40/977 (4%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGRD YGVFPLRGKLLNVREA++ Q+S N+EI++I KIL L+ GK Y+SV+SLR
Sbjct: 461  MAGISVVGRDHYGVFPLRGKLLNVREASHKQVSENKEIEAIKKILGLQTGKEYDSVKSLR 520

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  H+ WPSLLK+P+FL+EFITPI+KAT ++G++LSFY
Sbjct: 521  YGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLIEFITPIVKATHKSGKILSFY 580

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            ++PEYE+W++SL  N+SGWSIKYYKGLGTSTSKEGKEYFQDL+KH+KDF+W D +D ++I
Sbjct: 581  TMPEYESWRKSLGANSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADNQDGESI 640

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+A K WL+++EPGT+LDQKEK+I Y++FV+KELI FS+ADL+RSIPSM+DG
Sbjct: 641  ELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIPSMLDG 700

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRNF+KEAKV+Q SGYVSEHSAYHHGEQSL++TI+GMAQDY+GSNN+
Sbjct: 701  LKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYVGSNNV 760

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NLLQPNGQFGTR+ GGKDHAS+RYIYT LSPI RFLF K DD +  YLNEDGQ +EPTWY
Sbjct: 761  NLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKEDDTIHDYLNEDGQYIEPTWY 820

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            VP++PMVL+NG+EGIGTGWS+Y+PNYNPRD+VANVR  LNDEPMEPM PWYKGFKGTIE 
Sbjct: 821  VPIVPMVLINGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDEPMEPMDPWYKGFKGTIEK 880

Query: 1282 TNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKDF 1461
            T TK+AG +Y V GIIEEVN+TT+RI+ELPVR+ TE+YKQFL+ +     + K+ FIK+ 
Sbjct: 881  TATKEAGATYTVTGIIEEVNETTLRISELPVRRWTEDYKQFLESMTVSNDKAKDPFIKEV 940

Query: 1462 REFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPEK 1641
            R + D+ +V FE+ MSE+NL +A++EGL++KFKL+TTISTSNMHLF+  G + KY +PE 
Sbjct: 941  RAYGDENSVCFEVIMSEENLILAQQEGLLKKFKLATTISTSNMHLFDSNGKIKKYDNPED 1000

Query: 1642 IIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDEL 1821
            I+EEF  +RLE+YEKRK  +L +         NKV+FI  V++ +II+ NRKR+DLL EL
Sbjct: 1001 ILEEFYHVRLEYYEKRKKALLEILELELLRIENKVKFILGVVKVEIIVNNRKRADLLLEL 1060

Query: 1822 KQK--------------------------XXXXXXXXXXXXXXXXSMPIGTLTMEKVQEL 1923
            K+K                                          SMPIGTLT+EKVQEL
Sbjct: 1061 KEKGFTPFPKKKAVEAVVADTSDDAEDSEEELNRGVRAGDYDYLLSMPIGTLTLEKVQEL 1120

Query: 1924 CAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYDMPE------KRLEVNAEI 2085
            CA+R +LN EV+ +R+ATPK LWLKDLD LE++L+ Q KI    E      K+  +NA  
Sbjct: 1121 CAERDQLNGEVEDMRNATPKLLWLKDLDVLEKQLDEQDKIDIQAEEAREKIKKKVMNAAG 1180

Query: 2086 SKRPKRTMRKKQESSEKKANNKDGLAEKHTVPSDCTGKVPEAVELEGITTGRDEISTPNP 2265
             K PK   RK  + +    +  + +       S     V E V+ +     +   +   P
Sbjct: 1181 LKAPKPKPRKNVKKASVVESTAEPMDRVSCFNSGNRSNVTEVVKPKARGGSKKAPAKAKP 1240

Query: 2266 PSLDVNEDR------GLEQKEEQPKQSSSPDTSREPKMSVLQVPPEDNTRRNSADNLNAP 2427
             +++  E+        L+ +      +SSPD S E                  A    AP
Sbjct: 1241 IAVEDEEEEEDDEVLALKDRLAAYNLNSSPDHSAE------------------AMETEAP 1282

Query: 2428 IIEISDTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDEKLEDQIASTVESG 2607
              +          K++T  ++ ++S+     EDE+        S D++ E ++A   +  
Sbjct: 1283 KAQKKAPTRKAAAKKKTLPSIADVSEG----EDEI------EISDDDESEPEVAVGGKKK 1332

Query: 2608 MTSVDKTSQENKNRHVMITRKRANMSRQNGATSLANGSSGSVLKAVENI-MVSPEKKLRR 2784
                  T++          +KR   ++Q  A  +      S+LK  EN    SPEKK+R+
Sbjct: 1333 GGRKPATAKAAPAAAKQPPKKRGPANKQ--AVGIGQKLITSILKPAENTDNSSPEKKVRK 1390

Query: 2785 TSSFPFRKKKNYSPTKN 2835
              + PF +K      KN
Sbjct: 1391 MRASPFNEKSGAVLGKN 1407


>ref|XP_010257162.1| PREDICTED: LOW QUALITY PROTEIN: DNA topoisomerase 2-like [Nelumbo
            nucifera]
          Length = 1489

 Score =  964 bits (2491), Expect = 0.0
 Identities = 534/980 (54%), Positives = 654/980 (66%), Gaps = 51/980 (5%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGR+ YGVFPLRGKLLNVREAN+ QI  N EIQ+I +IL L++GK Y+SV+SLR
Sbjct: 469  MAGISVVGRNHYGVFPLRGKLLNVREANHKQIMENAEIQNIKQILGLQHGKEYDSVKSLR 528

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  H+ WPSLLKIP+FL+EFITP++KA  + G+VLSFY
Sbjct: 529  YGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKIPSFLVEFITPVVKAIHKNGRVLSFY 588

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            S+PEYE+WK+SL GN SGWSIKYYKGLGTSTSKEGKEYF+DL+ HKKDF+W++++D DAI
Sbjct: 589  SMPEYESWKESLAGNASGWSIKYYKGLGTSTSKEGKEYFKDLDMHKKDFIWINEQDGDAI 648

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+A K WL+ +EPGTYLDQKEK IKYSDFV+KELI FS+ADL+RSIPSMVDG
Sbjct: 649  ELAFSKKKIEARKNWLRNFEPGTYLDQKEKFIKYSDFVNKELILFSMADLQRSIPSMVDG 708

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRNFIKEAKVAQ SGYVSEHSAYHHGEQSL +TI+GMAQDY+GSNNI
Sbjct: 709  LKPGQRKILFCAFKRNFIKEAKVAQFSGYVSEHSAYHHGEQSLMSTIIGMAQDYVGSNNI 768

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NL QPNGQFGTRHQGGKDHASARYIYT LSPITRFLF K+DD LL YLNEDGQS+EPTWY
Sbjct: 769  NLFQPNGQFGTRHQGGKDHASARYIYTRLSPITRFLFPKDDDILLDYLNEDGQSIEPTWY 828

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            +P++PMVLVNG+EGIGTGWS+YIPNYNPRDIVAN+R  LN EPME M PWYKGF+G IE 
Sbjct: 829  MPIVPMVLVNGSEGIGTGWSSYIPNYNPRDIVANIRRLLNGEPMEAMDPWYKGFRGLIEK 888

Query: 1282 TNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKDF 1461
            T TK+AG SY V GIIE+ +                  K+FL+ +++   + KE FIKD+
Sbjct: 889  TATKEAGSSYTVSGIIEDXDD-----------------KEFLESIMTGNDKIKEPFIKDY 931

Query: 1462 REFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPEK 1641
            RE NDD TVHFE+ +SE+NL  AK+EGL++KFKL+TTISTSNMHLF+PKGV+ KY +PE+
Sbjct: 932  REHNDDTTVHFEVILSEENLQAAKQEGLMKKFKLTTTISTSNMHLFDPKGVIKKYDNPEQ 991

Query: 1642 IIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDEL 1821
            I+EEF  LRLEFYEKRK  +L           NKVRFI  V++G+II+ NRKR+DL  EL
Sbjct: 992  ILEEFFHLRLEFYEKRKKVLLDNLELDLLKLDNKVRFILGVVKGEIIVSNRKRADLFLEL 1051

Query: 1822 KQK-------------------------------XXXXXXXXXXXXXXXXSMPIGTLTME 1908
            +QK                                               SM IGTLT+E
Sbjct: 1052 QQKGFTPFPKKTKTVEVAVAGATEDAEENEENSEVVSSKGVRASDYEYLLSMAIGTLTLE 1111

Query: 1909 KVQELCAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYDMPE-KRLEVNAEI 2085
            KVQELCA   KLN EVD LR ATPK+LWL+DLD+LE++L+ Q K     E  R E+ + +
Sbjct: 1112 KVQELCADSNKLNHEVDELRKATPKTLWLRDLDALEKELDEQDKNDAQAEDARKELKSRV 1171

Query: 2086 S-----KRPKRTMRKKQESSEKKANNKDGLAEKHTVPSDC---TGKVPEAVELEGITTGR 2241
                  K  ++  +  ++++ KK NN + +AE           TG V E  + +G   G 
Sbjct: 1172 MSDAGLKVSRQAPKNPRKTNAKKNNNLEPVAESVAASVGSAMETGNVAEVAKPKG-RGGP 1230

Query: 2242 DEISTPNPPSL-----DVNEDRGLEQKEEQPKQS--SSPDTSREPKMSVLQVPPEDNTRR 2400
             + S      L     D +++  LE KE     +  SSPD S   +  V + P     R+
Sbjct: 1231 MKASAKKQDQLALADSDEDDEDVLELKERLAAYNLDSSPDQSAAMETEVAKPPA---ARK 1287

Query: 2401 NSADNLNAPIIEISDTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDEKLED 2580
                 + A              K+  +       D +V       N R N    DE  E 
Sbjct: 1288 KGPSKMAA------------AQKKHPSSYTENSDDDDVTMHTIEENMREN--GNDEDFEP 1333

Query: 2581 QIAST---VESGMTSVDKTSQENKNRHVMITRKRANMSRQNGATSLANGSSGSVLKAVEN 2751
            + A      + G        +    +    T+KR   ++Q   + L+      VLK V+N
Sbjct: 1334 EAAGPRGGKKGGRKPAAAKVKTAAAKPTAATKKRGPANKQ--PSLLSQKLITEVLKPVDN 1391

Query: 2752 IMVSPEKKLRRTSSFPFRKK 2811
              VSPEKK+R+  +FPF +K
Sbjct: 1392 SGVSPEKKVRKMRAFPFNRK 1411


>ref|XP_015060910.1| PREDICTED: DNA topoisomerase 2 isoform X2 [Solanum pennellii]
          Length = 1476

 Score =  962 bits (2488), Expect = 0.0
 Identities = 521/976 (53%), Positives = 660/976 (67%), Gaps = 39/976 (3%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGRD YGVFPLRGKLLNVREA++ Q+S N+EI+SI KIL L+ GK Y+SV+SLR
Sbjct: 462  MAGISVVGRDHYGVFPLRGKLLNVREASHKQVSENKEIESIKKILGLQTGKEYDSVKSLR 521

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  H+ WPSLLK+P+FL+EFITPI+KAT ++G++L+FY
Sbjct: 522  YGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSGRILAFY 581

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            ++PEYEAW++SL   +SGWSIKYYKGLGTSTSKEGKEYFQDL+KH+KDF+W D +D ++I
Sbjct: 582  TMPEYEAWRRSLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFVWADNQDGESI 641

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+A K WL+++EPGT+LDQKEK+I Y++FV+KELI FS+ADL+RSIPSM+DG
Sbjct: 642  ELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIPSMLDG 701

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRNF+KEAKV+Q SGYVSEHSAYHHGEQSL++TI+GMAQDY+GSNN+
Sbjct: 702  LKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYVGSNNV 761

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NLLQPNGQFGTR+ GGKDHAS+RYIYT LSPI RFLF K+DD +L YLNEDGQS+EPTWY
Sbjct: 762  NLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTILDYLNEDGQSIEPTWY 821

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            VP+IPMVLVNG+EGIGTGWS+Y+PNYNPRD+VANVR  LNDE MEPM PWYKGFKG IE 
Sbjct: 822  VPIIPMVLVNGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGFKGKIEK 881

Query: 1282 TNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKDF 1461
            T TK+ G +Y V GIIEEV++TT+RI+ELPVR+ TE+YKQFL+ +     + K+ FIK+ 
Sbjct: 882  TATKETGATYTVTGIIEEVSETTLRISELPVRRWTEDYKQFLESMTVSTDKAKDSFIKEV 941

Query: 1462 REFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPEK 1641
            R + D+ +V FE+ MSE NL +A++EGL++KFKL+TTISTSNMHLF+ KG + KY +PE+
Sbjct: 942  RAYGDENSVCFEVIMSEDNLLLAQQEGLLKKFKLTTTISTSNMHLFDSKGKIKKYDAPEE 1001

Query: 1642 IIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDEL 1821
            I+EEF  +RLE+YEKRK  +L +         NKV+FI  V++G+II+ NRKR++LL EL
Sbjct: 1002 ILEEFYHVRLEYYEKRKKALLEILELELLRIENKVKFILGVVKGEIIVNNRKRAELLLEL 1061

Query: 1822 KQK-----------------------------XXXXXXXXXXXXXXXXSMPIGTLTMEKV 1914
            K K                                             SM IGTLT+EKV
Sbjct: 1062 KNKGFTPFPKKKPVEAVVADSTDDADDSEESPEESNRGVRASDYDYLLSMAIGTLTLEKV 1121

Query: 1915 QELCAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYDMPE------KRLEVN 2076
            QELCA R KLN EV+ +R+ATPK LW+KDLD L+++L+ Q KI    E      K+  +N
Sbjct: 1122 QELCADRDKLNAEVEDMRNATPKDLWMKDLDVLDKQLDEQDKIDIQTEEAREKLKKKVMN 1181

Query: 2077 AEISKRPKRTMRKKQESSEKKANNKDGLAEKHTVPSDCTGKVPEAVELEGITTGRDEIST 2256
            A     PK   RK  + +E  A + D ++   T     T  V E V+ +G   GR   + 
Sbjct: 1182 AAGKAAPKPKPRKTNKKAESTAESMD-VSSGSTAE---TANVSEVVKPKG--RGRPAKAK 1235

Query: 2257 PNPPSLDVNEDRGLEQKEEQP--KQSSSPDTSREPKMSVLQVPPEDNTRRNSADNLNAPI 2430
            P     +  ED  L  K+       +SSPD S   +    +   +   +R +A     P 
Sbjct: 1236 PVVIEDEEEEDEVLALKDRLAAYNLNSSPDRSEVTETEAPKAQTKAPAKRAAAQKKALPS 1295

Query: 2431 I-EISDTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDEKLEDQIASTVESG 2607
              ++SD            E  IEI D E                       + A+ V   
Sbjct: 1296 TPDVSD-----------GEDAIEIDDDEF----------------------EPAAAVGGK 1322

Query: 2608 MTSVDKTSQENKNRHVMITRKRANMSRQNGATSLANGSSGSVLKAVENIMVSPEKKLRRT 2787
                 K +            KRA  +  N + S+       VLK  E+  VSP++K+R+ 
Sbjct: 1323 KKGGRKPAAAKAAAAPKPPEKRA--AANNQSQSVGQRLITQVLKPAEDAGVSPDRKVRKM 1380

Query: 2788 SSFPFRKKKNYSPTKN 2835
             + PF KK      KN
Sbjct: 1381 RASPFNKKSGAVMGKN 1396


>ref|XP_004229644.1| PREDICTED: DNA topoisomerase 2 isoform X2 [Solanum lycopersicum]
          Length = 1477

 Score =  959 bits (2480), Expect = 0.0
 Identities = 523/980 (53%), Positives = 659/980 (67%), Gaps = 43/980 (4%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGRD YGVFPLRGKLLNVREA++ Q+S N+EI+SI KIL L+ GK Y+SV+SLR
Sbjct: 462  MAGISVVGRDHYGVFPLRGKLLNVREASHKQVSENKEIESIKKILGLQTGKEYDSVKSLR 521

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  H+ WPSLLK+P+FL+EFITPI+KAT ++G++L+FY
Sbjct: 522  YGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSGRILAFY 581

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            ++PEYEAW++SL   +SGWSIKYYKGLGTSTSKEGKEYFQDL+KH+KDF+W D +D ++I
Sbjct: 582  TMPEYEAWRRSLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFVWADNQDGESI 641

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+A K WL+++EPGT+LDQKEK+I Y++FV+KELI FS+ADL+RSIPSM+DG
Sbjct: 642  ELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIPSMLDG 701

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRNF+KEAKV+Q SGYVSEHSAYHHGEQSL++TI+GMAQDY+GSNN+
Sbjct: 702  LKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYVGSNNV 761

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NLLQPNGQFGTR+ GGKDHAS+RYIYT LSPI RFLF K+DD +L YLNEDGQS+EPTWY
Sbjct: 762  NLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTILDYLNEDGQSIEPTWY 821

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            VPVIP VLVNG+EGIGTGWS+Y+PNYNPRD+VANVR  LNDE MEPM PWYKGFKG IE 
Sbjct: 822  VPVIPTVLVNGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGFKGKIEK 881

Query: 1282 TNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKDF 1461
            T TK+ G +Y V GIIEEV++TT+RI+ELPVR+ TE+YKQFL+ +     + K+ FIK+ 
Sbjct: 882  TATKETGATYTVTGIIEEVSETTLRISELPVRRWTEDYKQFLESMTVSTDKAKDSFIKEV 941

Query: 1462 REFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPEK 1641
            R + D+ +V FE+ MSE NL +A++EGL++KFKL+TTISTSNMHLF+ KG + KY +PE+
Sbjct: 942  RAYGDENSVCFEVIMSEDNLLLAQQEGLLKKFKLTTTISTSNMHLFDSKGKIKKYDAPEE 1001

Query: 1642 IIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDEL 1821
            I+EEF  +RLE+YEKRK  +L +         NKV+FI  V++G+II+ NRKR++LL EL
Sbjct: 1002 ILEEFYHVRLEYYEKRKKALLEILELELLRIENKVKFILGVVKGEIIVNNRKRAELLLEL 1061

Query: 1822 KQK-----------------------------XXXXXXXXXXXXXXXXSMPIGTLTMEKV 1914
            K K                                             SM IGTLT+EKV
Sbjct: 1062 KNKGFTPFPKKKPVEAVVADSTDDADDSEESPEESSRGVRASDYDYLLSMAIGTLTLEKV 1121

Query: 1915 QELCAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYDMPE------KRLEVN 2076
            QELCA R KLN EV+ +R+ATPK LW+KDLD L+++L+ Q KI    E      K+  +N
Sbjct: 1122 QELCADRDKLNAEVEDMRNATPKHLWMKDLDVLDKQLDEQDKIDIQTEEAREKLKKKVMN 1181

Query: 2077 AEISKRPKRTMRKKQESSEKKANNKD----GLAEKHTVPSDCTGKVPEAVELEGITTGRD 2244
            A     PK   RK  + +E  A + D      AE        T  V E V+ +G   GR 
Sbjct: 1182 AAGKAAPKPKPRKTNKKAESTAESMDVSFGSTAE--------TANVSEVVKPKG--RGRP 1231

Query: 2245 EISTPNPPSLDVNEDRGLEQKEEQP--KQSSSPDTSREPKMSVLQVPPEDNTRRNSADNL 2418
              + P     +  ED  L  K+       +SSPD S   +  V +   +   +R +A   
Sbjct: 1232 AKAKPIVVEDEEEEDEVLALKDRLAAYNLNSSPDRSEVTETEVPKAQTKAPAKRAAAQKK 1291

Query: 2419 NAPII-EISDTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDEKLEDQIAST 2595
              P   ++SD            E  IEI D E      V   +     G  K     A+ 
Sbjct: 1292 ALPSTPDVSD-----------GEDAIEIDDDEFEPAAAVGGKK----KGGRK---PAAAK 1333

Query: 2596 VESGMTSVDKTSQENKNRHVMITRKRANMSRQNGATSLANGSSGSVLKAVENIMVSPEKK 2775
              +      K +  N                 N + S+       VLK  E+  VSP++K
Sbjct: 1334 AAAAPKPPGKKAPAN-----------------NQSQSVGQRLITQVLKPAEDAGVSPDRK 1376

Query: 2776 LRRTSSFPFRKKKNYSPTKN 2835
            +R+  + PF KK      KN
Sbjct: 1377 VRKMRASPFNKKSGAVMGKN 1396


>ref|XP_010023597.1| PREDICTED: DNA topoisomerase 2-like [Eucalyptus grandis]
            gi|629093914|gb|KCW59909.1| hypothetical protein
            EUGRSUZ_H02633 [Eucalyptus grandis]
          Length = 1438

 Score =  959 bits (2479), Expect = 0.0
 Identities = 517/945 (54%), Positives = 652/945 (68%), Gaps = 49/945 (5%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAG+S VGRD YGVFPLRGKLLNVREA++ QI  N+EIQ + +IL L+  K+Y+SV+SLR
Sbjct: 475  MAGLSVVGRDRYGVFPLRGKLLNVREASHSQIMENKEIQYMKQILGLQQNKDYDSVKSLR 534

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  HS WPSLLK+P+FL+EFITPI+KAT + G+ LSFY
Sbjct: 535  YGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPSFLVEFITPIVKATHKNGRELSFY 594

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            ++PEYE+WK+SL GN SGWSIKYYKGLGTSTSKEGK+YFQ+L+ HKKDF+W+D +D DAI
Sbjct: 595  TMPEYESWKESLGGNASGWSIKYYKGLGTSTSKEGKQYFQNLQLHKKDFVWVDDQDGDAI 654

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+A K WL++YEPGTYLDQKEK IKYSDFV+KELI FS+ADL+RSIPSMVDG
Sbjct: 655  ELAFSKKKIEARKTWLRQYEPGTYLDQKEKLIKYSDFVNKELILFSMADLQRSIPSMVDG 714

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRNFIKEAKVAQ SGYVSEHSAYHHGEQSLA+TI+GMAQD++GSNNI
Sbjct: 715  LKPGQRKILFCSFKRNFIKEAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNI 774

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NLL PNGQFGTR+ GGKDHAS+RYIYT LSPITRFLF K+DD LL+YLNEDGQS+EPTWY
Sbjct: 775  NLLMPNGQFGTRNLGGKDHASSRYIYTKLSPITRFLFPKDDDNLLNYLNEDGQSIEPTWY 834

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            +P++P VLVNG+EGIGTGWS+YIPNYNPRDI+AN+R  LN E MEPM PWY+GF+GTIE 
Sbjct: 835  MPILPTVLVNGSEGIGTGWSSYIPNYNPRDIIANLRRLLNGEMMEPMDPWYRGFRGTIEK 894

Query: 1282 TNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNK--EQFIK 1455
            T TK+AG SY V GI+EEV+ TT+RITELP+R+ T++Y++FL+ L S G R+K  + F+K
Sbjct: 895  TATKEAGVSYTVCGIVEEVDDTTLRITELPIRRWTQDYREFLESL-STGERDKTKDPFVK 953

Query: 1456 DFREFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSP 1635
            +FR+++DD TVHFE+ ++E+N+ +AK+EGL++KFKL++TISTSNMHLF+  GV+ KY SP
Sbjct: 954  EFRQYSDDVTVHFEVMLTEENMMIAKQEGLLKKFKLTSTISTSNMHLFDSNGVIKKYDSP 1013

Query: 1636 EKIIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLD 1815
            E+I+EEF  LRLE YEKRK  +L           NKVRFI  V+ G+II+ NRKR+DL  
Sbjct: 1014 EQILEEFFHLRLECYEKRKKILLENLELKLVMLDNKVRFILGVVHGEIIVSNRKRADLFQ 1073

Query: 1816 ELKQKXXXXXXXXXXXXXXXX-----------------------------SMPIGTLTME 1908
            EL+ K                                             SM IGTLT+E
Sbjct: 1074 ELQAKGFAPFRKETKTIETGVAGSTDDSEEIEENSGATKGVRASDYEYLLSMAIGTLTLE 1133

Query: 1909 KVQELCAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYDMPEKRLEVNAE-- 2082
            KVQELCA + KL  EVD LR ATP++LWLKDL +LE+KL+ Q KI    E+  +  ++  
Sbjct: 1134 KVQELCADKDKLVNEVDDLRKATPENLWLKDLAALEEKLDEQEKIDAQAEETRKARSKTN 1193

Query: 2083 -ISKRPKRTMRKKQESSEKKANNKDGLAEKHTVPSDCTGKVPEAVELEGIT--------T 2235
             +  +  R   KK   +  KA N +  AE        T     A+E E +          
Sbjct: 1194 GVGTKVSRQAPKKPRQNNSKAKNSEAQAE-------VTRGSTVALEAENVADVVKPKRGA 1246

Query: 2236 GRDEISTPNP-PSLDVNEDRGLEQKEEQPKQS-----SSPDTSREPKMSVLQVPPEDNTR 2397
            G  +   P P  S  V++D   E  + + + +     SSPD S   +  V ++P +    
Sbjct: 1247 GAKKAPAPKPRKSASVSDDEDFELLDLRERLAAYNLESSPDNSSALEDKVPEIPVKAKEP 1306

Query: 2398 RNSADNLNAPIIEISDTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDEKLE 2577
               A +     + +SDT  + EN   + +   E+ DSE           +    G  K  
Sbjct: 1307 SKRAASKKKASVILSDTSEE-ENSNDSGDNDDEVVDSE---------AEVAKKKGGRK-- 1354

Query: 2578 DQIASTVESGMTSVDKTSQENKNRHVMITRKRANMSRQNGATSLA 2712
               A+   S   +  K  Q NK +    T+++A+ S  +    +A
Sbjct: 1355 -PAAAAKISKPPAAAKKGQANKQQAQGTTQRKADSSTSDDTEEVA 1398


>ref|XP_015060904.1| PREDICTED: DNA topoisomerase 2 isoform X1 [Solanum pennellii]
          Length = 1477

 Score =  959 bits (2478), Expect = 0.0
 Identities = 521/977 (53%), Positives = 661/977 (67%), Gaps = 40/977 (4%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGRD YGVFPLRGKLLNVREA++ Q+S N+EI+SI KIL L+ GK Y+SV+SLR
Sbjct: 462  MAGISVVGRDHYGVFPLRGKLLNVREASHKQVSENKEIESIKKILGLQTGKEYDSVKSLR 521

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  H+ WPSLLK+P+FL+EFITPI+KAT ++G++L+FY
Sbjct: 522  YGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSGRILAFY 581

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            ++PEYEAW++SL   +SGWSIKYYKGLGTSTSKEGKEYFQDL+KH+KDF+W D +D ++I
Sbjct: 582  TMPEYEAWRRSLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFVWADNQDGESI 641

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+A K WL+++EPGT+LDQKEK+I Y++FV+KELI FS+ADL+RSIPSM+DG
Sbjct: 642  ELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIPSMLDG 701

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRNF+KEAKV+Q SGYVSEHSAYHHGEQSL++TI+GMAQDY+GSNN+
Sbjct: 702  LKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYVGSNNV 761

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NLLQPNGQFGTR+ GGKDHAS+RYIYT LSPI RFLF K+DD +L YLNEDGQS+EPTWY
Sbjct: 762  NLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTILDYLNEDGQSIEPTWY 821

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            VP+IPMVLVNG+EGIGTGWS+Y+PNYNPRD+VANVR  LNDE MEPM PWYKGFKG IE 
Sbjct: 822  VPIIPMVLVNGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGFKGKIEK 881

Query: 1282 TNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKDF 1461
            T TK+ G +Y V GIIEEV++TT+RI+ELPVR+ TE+YKQFL+ +     + K+ FIK+ 
Sbjct: 882  TATKETGATYTVTGIIEEVSETTLRISELPVRRWTEDYKQFLESMTVSTDKAKDSFIKEV 941

Query: 1462 REFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPEK 1641
            R + D+ +V FE+ MSE NL +A++EGL++KFKL+TTISTSNMHLF+ KG + KY +PE+
Sbjct: 942  RAYGDENSVCFEVIMSEDNLLLAQQEGLLKKFKLTTTISTSNMHLFDSKGKIKKYDAPEE 1001

Query: 1642 IIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDEL 1821
            I+EEF  +RLE+YEKRK  +L +         NKV+FI  V++G+II+ NRKR++LL EL
Sbjct: 1002 ILEEFYHVRLEYYEKRKKALLEILELELLRIENKVKFILGVVKGEIIVNNRKRAELLLEL 1061

Query: 1822 KQK-----------------------------XXXXXXXXXXXXXXXXSMPIGTLTMEKV 1914
            K K                                             SM IGTLT+EKV
Sbjct: 1062 KNKGFTPFPKKKPVEAVVADSTDDADDSEESPEESNRGVRASDYDYLLSMAIGTLTLEKV 1121

Query: 1915 QELCAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYDMPE------KRLEVN 2076
            QELCA R KLN EV+ +R+ATPK LW+KDLD L+++L+ Q KI    E      K+  +N
Sbjct: 1122 QELCADRDKLNAEVEDMRNATPKDLWMKDLDVLDKQLDEQDKIDIQTEEAREKLKKKVMN 1181

Query: 2077 AEISKRPKRTMRKKQESSEKKANNKDGLAEKHTVPSDCTGKVPEAVELEGITTGRD-EIS 2253
            A     PK   RK  + +E  A + D ++   T     T  V E V+ +G   GR  + +
Sbjct: 1182 AAGKAAPKPKPRKTNKKAESTAESMD-VSSGSTAE---TANVSEVVKPKG--RGRPAKQA 1235

Query: 2254 TPNPPSLDVNEDRGLEQKEEQP--KQSSSPDTSREPKMSVLQVPPEDNTRRNSADNLNAP 2427
             P     +  ED  L  K+       +SSPD S   +    +   +   +R +A     P
Sbjct: 1236 KPVVIEDEEEEDEVLALKDRLAAYNLNSSPDRSEVTETEAPKAQTKAPAKRAAAQKKALP 1295

Query: 2428 II-EISDTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDEKLEDQIASTVES 2604
               ++SD            E  IEI D E                       + A+ V  
Sbjct: 1296 STPDVSD-----------GEDAIEIDDDEF----------------------EPAAAVGG 1322

Query: 2605 GMTSVDKTSQENKNRHVMITRKRANMSRQNGATSLANGSSGSVLKAVENIMVSPEKKLRR 2784
                  K +            KRA  +  N + S+       VLK  E+  VSP++K+R+
Sbjct: 1323 KKKGGRKPAAAKAAAAPKPPEKRA--AANNQSQSVGQRLITQVLKPAEDAGVSPDRKVRK 1380

Query: 2785 TSSFPFRKKKNYSPTKN 2835
              + PF KK      KN
Sbjct: 1381 MRASPFNKKSGAVMGKN 1397


>ref|XP_010324649.1| PREDICTED: DNA topoisomerase 2 isoform X1 [Solanum lycopersicum]
          Length = 1478

 Score =  956 bits (2470), Expect = 0.0
 Identities = 523/981 (53%), Positives = 660/981 (67%), Gaps = 44/981 (4%)
 Frame = +1

Query: 25   MAGISAVGRDCYGVFPLRGKLLNVREANNYQISGNEEIQSIMKILRLEYGKNYNSVESLR 204
            MAGIS VGRD YGVFPLRGKLLNVREA++ Q+S N+EI+SI KIL L+ GK Y+SV+SLR
Sbjct: 462  MAGISVVGRDHYGVFPLRGKLLNVREASHKQVSENKEIESIKKILGLQTGKEYDSVKSLR 521

Query: 205  YGHVMIMTDQDHDGSHIKGLLINLFHSLWPSLLKIPTFLLEFITPIIKAT-RAGQVLSFY 381
            YGH+MIMTDQDHDGSHIKGLLIN  H+ WPSLLK+P+FL+EFITPI+KAT ++G++L+FY
Sbjct: 522  YGHLMIMTDQDHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSGRILAFY 581

Query: 382  SIPEYEAWKQSLDGNNSGWSIKYYKGLGTSTSKEGKEYFQDLEKHKKDFLWLDKKDNDAI 561
            ++PEYEAW++SL   +SGWSIKYYKGLGTSTSKEGKEYFQDL+KH+KDF+W D +D ++I
Sbjct: 582  TMPEYEAWRRSLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFVWADNQDGESI 641

Query: 562  ELAFSKHKIQAMKKWLQKYEPGTYLDQKEKHIKYSDFVDKELIQFSVADLKRSIPSMVDG 741
            ELAFSK KI+A K WL+++EPGT+LDQKEK+I Y++FV+KELI FS+ADL+RSIPSM+DG
Sbjct: 642  ELAFSKKKIEARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIPSMLDG 701

Query: 742  FKPGQRKILFSCFKRNFIKEAKVAQLSGYVSEHSAYHHGEQSLANTIVGMAQDYMGSNNI 921
             KPGQRKILF  FKRNF+KEAKV+Q SGYVSEHSAYHHGEQSL++TI+GMAQDY+GSNN+
Sbjct: 702  LKPGQRKILFCAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYVGSNNV 761

Query: 922  NLLQPNGQFGTRHQGGKDHASARYIYTCLSPITRFLFNKNDDALLHYLNEDGQSVEPTWY 1101
            NLLQPNGQFGTR+ GGKDHAS+RYIYT LSPI RFLF K+DD +L YLNEDGQS+EPTWY
Sbjct: 762  NLLQPNGQFGTRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTILDYLNEDGQSIEPTWY 821

Query: 1102 VPVIPMVLVNGTEGIGTGWSTYIPNYNPRDIVANVRHFLNDEPMEPMIPWYKGFKGTIES 1281
            VPVIP VLVNG+EGIGTGWS+Y+PNYNPRD+VANVR  LNDE MEPM PWYKGFKG IE 
Sbjct: 822  VPVIPTVLVNGSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGFKGKIEK 881

Query: 1282 TNTKDAGKSYVVKGIIEEVNKTTVRITELPVRKSTEEYKQFLDKLISKGGRNKEQFIKDF 1461
            T TK+ G +Y V GIIEEV++TT+RI+ELPVR+ TE+YKQFL+ +     + K+ FIK+ 
Sbjct: 882  TATKETGATYTVTGIIEEVSETTLRISELPVRRWTEDYKQFLESMTVSTDKAKDSFIKEV 941

Query: 1462 REFNDDKTVHFEIYMSEKNLAMAKEEGLIEKFKLSTTISTSNMHLFNPKGVLAKYSSPEK 1641
            R + D+ +V FE+ MSE NL +A++EGL++KFKL+TTISTSNMHLF+ KG + KY +PE+
Sbjct: 942  RAYGDENSVCFEVIMSEDNLLLAQQEGLLKKFKLTTTISTSNMHLFDSKGKIKKYDAPEE 1001

Query: 1642 IIEEFCDLRLEFYEKRKIFMLSMXXXXXXXXXNKVRFIDEVIQGKIILMNRKRSDLLDEL 1821
            I+EEF  +RLE+YEKRK  +L +         NKV+FI  V++G+II+ NRKR++LL EL
Sbjct: 1002 ILEEFYHVRLEYYEKRKKALLEILELELLRIENKVKFILGVVKGEIIVNNRKRAELLLEL 1061

Query: 1822 KQK-----------------------------XXXXXXXXXXXXXXXXSMPIGTLTMEKV 1914
            K K                                             SM IGTLT+EKV
Sbjct: 1062 KNKGFTPFPKKKPVEAVVADSTDDADDSEESPEESSRGVRASDYDYLLSMAIGTLTLEKV 1121

Query: 1915 QELCAQRKKLNVEVDGLRHATPKSLWLKDLDSLEQKLNLQSKIYDMPE------KRLEVN 2076
            QELCA R KLN EV+ +R+ATPK LW+KDLD L+++L+ Q KI    E      K+  +N
Sbjct: 1122 QELCADRDKLNAEVEDMRNATPKHLWMKDLDVLDKQLDEQDKIDIQTEEAREKLKKKVMN 1181

Query: 2077 AEISKRPKRTMRKKQESSEKKANNKD----GLAEKHTVPSDCTGKVPEAVELEGITTGRD 2244
            A     PK   RK  + +E  A + D      AE        T  V E V+ +G   GR 
Sbjct: 1182 AAGKAAPKPKPRKTNKKAESTAESMDVSFGSTAE--------TANVSEVVKPKG--RGRP 1231

Query: 2245 -EISTPNPPSLDVNEDRGLEQKEEQP--KQSSSPDTSREPKMSVLQVPPEDNTRRNSADN 2415
             + + P     +  ED  L  K+       +SSPD S   +  V +   +   +R +A  
Sbjct: 1232 AKQAKPIVVEDEEEEDEVLALKDRLAAYNLNSSPDRSEVTETEVPKAQTKAPAKRAAAQK 1291

Query: 2416 LNAPII-EISDTEVDCENKQQTAETVIEISDSEVVCEDEVPNTRINNPSGDEKLEDQIAS 2592
               P   ++SD            E  IEI D E      V   +     G  K     A+
Sbjct: 1292 KALPSTPDVSD-----------GEDAIEIDDDEFEPAAAVGGKK----KGGRK---PAAA 1333

Query: 2593 TVESGMTSVDKTSQENKNRHVMITRKRANMSRQNGATSLANGSSGSVLKAVENIMVSPEK 2772
               +      K +  N                 N + S+       VLK  E+  VSP++
Sbjct: 1334 KAAAAPKPPGKKAPAN-----------------NQSQSVGQRLITQVLKPAEDAGVSPDR 1376

Query: 2773 KLRRTSSFPFRKKKNYSPTKN 2835
            K+R+  + PF KK      KN
Sbjct: 1377 KVRKMRASPFNKKSGAVMGKN 1397