BLASTX 2.2.26 [Sep-21-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Rehmannia27_contig00002397
         (3698 letters)

Database: ./nr 
           84,704,028 sequences; 31,038,470,784 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

ref|XP_011093631.1| PREDICTED: DNA topoisomerase 1-like [Sesamum...  1427   0.0  
ref|XP_012845487.1| PREDICTED: DNA topoisomerase 1-like [Erythra...  1209   0.0  
gb|EYU30724.1| hypothetical protein MIMGU_mgv1a001121mg [Erythra...  1209   0.0  
emb|CDP13767.1| unnamed protein product [Coffea canephora]           1162   0.0  
dbj|BAG31376.1| topoisomerase I [Camptotheca acuminata]              1141   0.0  
dbj|BAG31377.1| topoisomerase I [Catharanthus roseus]                1129   0.0  
dbj|BAK32960.1| topoisomerase I [Ophiorrhiza pseudofasciculata]      1122   0.0  
dbj|BAG31375.1| topoisomerase I [Ophiorrhiza japonica]               1119   0.0  
dbj|BAK32958.1| topoisomerase I [Ophiorrhiza pedunculata]            1115   0.0  
dbj|BAK32962.1| topoisomerase I [Ophiorrhiza trichocarpon var. g...  1112   0.0  
ref|XP_006364175.2| PREDICTED: DNA topoisomerase 1-like [Solanum...  1104   0.0  
gb|KHG20024.1| DNA topoisomerase 1 -like protein [Gossypium arbo...  1102   0.0  
dbj|BAK32961.1| topoisomerase I [Ophiorrhiza ridleyana]              1099   0.0  
dbj|BAG31373.1| topoisomerase I [Ophiorrhiza pumila]                 1098   0.0  
dbj|BAK32956.1| topoisomerase I [Ophiorrhiza fucosa]                 1097   0.0  
dbj|BAG31374.1| topoisomerase I [Ophiorrhiza liukiuensis]            1096   0.0  
ref|XP_009619726.1| PREDICTED: LOW QUALITY PROTEIN: DNA topoisom...  1095   0.0  
ref|XP_009790344.1| PREDICTED: LOW QUALITY PROTEIN: DNA topoisom...  1082   0.0  
dbj|BAK32959.1| topoisomerase I [Ophiorrhiza plumbea]                1082   0.0  
dbj|BAK32963.1| topoisomerase I [Ophiorrhiza sp. 35]                 1082   0.0  

>ref|XP_011093631.1| PREDICTED: DNA topoisomerase 1-like [Sesamum indicum]
          Length = 893

 Score = 1427 bits (3695), Expect = 0.0
 Identities = 724/893 (81%), Positives = 759/893 (84%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDVR 3031
            MA+E+C+ QKL        EPLVFKR           SE K+ LSQKHDR L RP+PDVR
Sbjct: 1    MAIESCNDQKLMDDMDEDDEPLVFKRSSSSAKQSQGNSETKRPLSQKHDRPLNRPSPDVR 60

Query: 3030 SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 2851
             QNGQST+++KSKTVP S+TPP++ PL SPKSSN+S KALA++  EVD +PSTSVTD+SN
Sbjct: 61   PQNGQSTMIQKSKTVPSSRTPPLRSPLASPKSSNSSAKALAVRPREVDPRPSTSVTDESN 120

Query: 2850 SVKHQIKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTSTLSQK 2671
            SVKHQIKDEK ST+ATG  NEDS+DSEDDKPLSARLPAGLSKVNSNHA K PN  T  QK
Sbjct: 121  SVKHQIKDEKPSTKATGGLNEDSEDSEDDKPLSARLPAGLSKVNSNHANKGPNALTSVQK 180

Query: 2670 RRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTERKPSTN 2491
             +IP PEDSDDEIPLSSKFQVKSNAGES NR S SGERKPLL+KYDQNGSAS ERKPST 
Sbjct: 181  TKIPKPEDSDDEIPLSSKFQVKSNAGESTNRPSISGERKPLLAKYDQNGSASAERKPSTI 240

Query: 2490 LKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDEDHVPISHRMXXXXX 2311
            LKKRP DGVK+  ESYLKKPKLS+A+TP+K KE SIK EM++EDDEDHVPIS R+     
Sbjct: 241  LKKRPADGVKSAGESYLKKPKLSDASTPNKTKETSIKDEMKDEDDEDHVPISQRIKQQTS 300

Query: 2310 XXXXXXXXKNITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSGEGQKWTTLVHNGVI 2131
                    KN+TKPI                             SGEGQKWTTLVHNGVI
Sbjct: 301  SDKKSSSAKNMTKPISASAKKTSKKPKKVMKNSKYSKSSKVPPSSGEGQKWTTLVHNGVI 360

Query: 2130 FPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKPKFKENFMADWRKILGK 1951
            FPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVML+TDYMNKPKFKENFMADWRKILGK
Sbjct: 361  FPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLDTDYMNKPKFKENFMADWRKILGK 420

Query: 1950 NHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXXXXKYMWAIVNGVKEKV 1771
            NH IQSLEHCDFTPIYEWH                           KYMWAIVNGVKEKV
Sbjct: 421  NHVIQSLEHCDFTPIYEWHQKEKEKKKQMTAEEKKALKEEKLKQEEKYMWAIVNGVKEKV 480

Query: 1770 GNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWKEIRHDNT 1591
            GNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWKEIRHDNT
Sbjct: 481  GNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWKEIRHDNT 540

Query: 1590 VTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYILGIRAAYTKDFTSK 1411
            VTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYI GIRAAYTKDFT+K
Sbjct: 541  VTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYIHGIRAAYTKDFTNK 600

Query: 1410 DPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNTLKFDFLGKDS 1231
            DP K+QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPN LKFDFLGKDS
Sbjct: 601  DPTKKQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNILKFDFLGKDS 660

Query: 1230 IRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNA 1051
            IRYQNEVEVET VFKAIQQFRSGKKG DD+FDRLDTSKLNAHLKELMPGLTAKVFRTYNA
Sbjct: 661  IRYQNEVEVETPVFKAIQQFRSGKKGSDDMFDRLDTSKLNAHLKELMPGLTAKVFRTYNA 720

Query: 1050 SITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMLRLNEKIEELK 871
            SITLDD LSRET+GGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQM RLNEKIEELK
Sbjct: 721  SITLDDKLSRETKGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMTRLNEKIEELK 780

Query: 870  GVVEELQTDLARAKKGKPPLKSADGKPKRNLNPDALERKIAQTTAKIEKMERDKETKEDL 691
            GV+EELQTDLARAKKGKPPLKSADGKPKRNLNPDALE+KIAQT AKIEKMERDKETKEDL
Sbjct: 781  GVLEELQTDLARAKKGKPPLKSADGKPKRNLNPDALEKKIAQTNAKIEKMERDKETKEDL 840

Query: 690  KTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPGFRF 532
            KTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDP FRF
Sbjct: 841  KTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPSFRF 893


>ref|XP_012845487.1| PREDICTED: DNA topoisomerase 1-like [Erythranthe guttata]
          Length = 894

 Score = 1209 bits (3127), Expect = 0.0
 Identities = 635/909 (69%), Positives = 701/909 (77%), Gaps = 16/909 (1%)
 Frame = -3

Query: 3210 MAVEAC-DKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDV 3034
            M VEA  DK  +         PLVFKR            E K S SQKH+ Q+GR + DV
Sbjct: 1    MTVEAREDKNMMEDMDDDDDAPLVFKRSGSSSKPKQSEPENKLS-SQKHNAQVGRQSSDV 59

Query: 3033 RSQNGQSTIVKKSKTVPLSKT--PPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTD 2860
            R QNG +   +K K+V  S +  PPV+  L SPKSSN+S KA  +KSP+V+SKPSTSV  
Sbjct: 60   RPQNGTNANAQKGKSVTSSSSMKPPVRPSLVSPKSSNSSVKASPIKSPDVNSKPSTSVVG 119

Query: 2859 KSNSVKHQIKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTSTL 2680
            +S SVK  IK+E            +S+DSEDDKPLSAR  AG SK N N   K PN   L
Sbjct: 120  ESKSVKSTIKEE------------NSEDSEDDKPLSARQVAGSSKNNPNQTNK-PNAPNL 166

Query: 2679 SQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLS-KYDQNGSASTERK 2503
             +K  +P PEDSDDEIPLS+KFQ KSNAG S +RSS+S E+KPL++ K D+NGSASTERK
Sbjct: 167  GKKSNVPKPEDSDDEIPLSAKFQGKSNAGASTSRSSHSEEKKPLVARKPDKNGSASTERK 226

Query: 2502 PSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDEDHVPISHRMX 2323
            PST L+KRP DGV +  +S LKKPKLS++    K+K+AS+K E++ EDDED VP+S R  
Sbjct: 227  PSTVLQKRPADGVASAGQSNLKKPKLSDSLAS-KDKKASVKPEVKAEDDEDLVPLSQRTK 285

Query: 2322 XXXXXXXXXXXXKNITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXS----------- 2176
                          +TK                               +           
Sbjct: 286  KSTTPEKKPSPALKVTKSTASISKKTNNKTNSKTNSKTNKKSKQVSKDNNYSKSSKLPPS 345

Query: 2175 -GEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKP 1999
             G+GQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPV+LTPEQEEVATMYAVMLETDY+ KP
Sbjct: 346  SGDGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVNLTPEQEEVATMYAVMLETDYLKKP 405

Query: 1998 KFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXX 1819
            +FKENFM DW+KILGKNH IQSLEHCDFTPIYEWH                         
Sbjct: 406  QFKENFMTDWKKILGKNHVIQSLEHCDFTPIYEWHQREKEKKKQMSTDEKKALKEEKLKL 465

Query: 1818 XXKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPE 1639
              KYMWA+++GV+EKVGNFRVEPPGLFRGRGEHPKMGKLK+RIRPSDITINIG+DAPIPE
Sbjct: 466  EEKYMWAVLDGVREKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDITINIGRDAPIPE 525

Query: 1638 CPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKD 1459
            CPI GE WKEIRHDNTVTWLAYW+DPIN KEFKYVFLAASSTLKGQSDKEKYEKARLLKD
Sbjct: 526  CPIEGERWKEIRHDNTVTWLAYWSDPINGKEFKYVFLAASSTLKGQSDKEKYEKARLLKD 585

Query: 1458 YILGIRAAYTKDFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVE 1279
            YI GIR AYT+DF SKDPAK+QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVE
Sbjct: 586  YIQGIRTAYTRDFVSKDPAKKQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVE 645

Query: 1278 PVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLK 1099
            PVPPN LKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFD+LDTSKLNAHLK
Sbjct: 646  PVPPNILKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDKLDTSKLNAHLK 705

Query: 1098 ELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKS 919
            ELMPGLTAKVFRTYNASITLDD LSRET+GGD+AEKVV Y HANKEVAIICNHQRTVSK+
Sbjct: 706  ELMPGLTAKVFRTYNASITLDDKLSRETKGGDLAEKVVTYNHANKEVAIICNHQRTVSKT 765

Query: 918  HSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNLNPDALERKIAQTT 739
            HSAQMLRL+EKI+ELKGV+EEL+TDL RA+KGKP L  ADGK KRN+NP+ALERKIAQTT
Sbjct: 766  HSAQMLRLDEKIDELKGVLEELKTDLGRARKGKPLLAGADGKAKRNINPEALERKIAQTT 825

Query: 738  AKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWA 559
            AKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK+FNKSLL KF+WA
Sbjct: 826  AKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKMFNKSLLEKFSWA 885

Query: 558  MDVDPGFRF 532
            MDVDP FRF
Sbjct: 886  MDVDPSFRF 894


>gb|EYU30724.1| hypothetical protein MIMGU_mgv1a001121mg [Erythranthe guttata]
          Length = 883

 Score = 1209 bits (3127), Expect = 0.0
 Identities = 635/898 (70%), Positives = 699/898 (77%), Gaps = 5/898 (0%)
 Frame = -3

Query: 3210 MAVEAC-DKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDV 3034
            M VEA  DK  +         PLVFKR            E K S SQKH+ Q+GR + DV
Sbjct: 1    MTVEAREDKNMMEDMDDDDDAPLVFKRSGSSSKPKQSEPENKLS-SQKHNAQVGRQSSDV 59

Query: 3033 RSQNGQSTIVKKSKTVPLSKT--PPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTD 2860
            R QNG +   +K K+V  S +  PPV+  L SPKSSN+S KA  +KSP+V+SKPSTSV  
Sbjct: 60   RPQNGTNANAQKGKSVTSSSSMKPPVRPSLVSPKSSNSSVKASPIKSPDVNSKPSTSVVG 119

Query: 2859 KSNSVKHQIKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTSTL 2680
            +S SVK  IK+E            +S+DSEDDKPLSAR  AG SK N N   K PN   L
Sbjct: 120  ESKSVKSTIKEE------------NSEDSEDDKPLSARQVAGSSKNNPNQTNK-PNAPNL 166

Query: 2679 SQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLS-KYDQNGSASTERK 2503
             +K  +P PEDSDDEIPLS+KFQ KSNAG S +RSS+S E+KPL++ K D+NGSASTERK
Sbjct: 167  GKKSNVPKPEDSDDEIPLSAKFQGKSNAGASTSRSSHSEEKKPLVARKPDKNGSASTERK 226

Query: 2502 PSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDEDHVPISHRMX 2323
            PST L+KRP DGV +  +S LKKPKLS++    K+K+AS+K E++ EDDED VP+S R  
Sbjct: 227  PSTVLQKRPADGVASAGQSNLKKPKLSDSLAS-KDKKASVKPEVKAEDDEDLVPLSQRTK 285

Query: 2322 XXXXXXXXXXXXKNIT-KPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSGEGQKWTTLV 2146
                             K                               SG+GQKWTTLV
Sbjct: 286  KSTTPEKKPSPALKTNNKTNSKTNSKTNKKSKQVSKDNNYSKSSKLPPSSGDGQKWTTLV 345

Query: 2145 HNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKPKFKENFMADWR 1966
            HNGVIFPPPYKPHGVKMLYKGKPV+LTPEQEEVATMYAVMLETDY+ KP+FKENFM DW+
Sbjct: 346  HNGVIFPPPYKPHGVKMLYKGKPVNLTPEQEEVATMYAVMLETDYLKKPQFKENFMTDWK 405

Query: 1965 KILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXXXXKYMWAIVNG 1786
            KILGKNH IQSLEHCDFTPIYEWH                           KYMWA+++G
Sbjct: 406  KILGKNHVIQSLEHCDFTPIYEWHQREKEKKKQMSTDEKKALKEEKLKLEEKYMWAVLDG 465

Query: 1785 VKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWKEI 1606
            V+EKVGNFRVEPPGLFRGRGEHPKMGKLK+RIRPSDITINIG+DAPIPECPI GE WKEI
Sbjct: 466  VREKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDITINIGRDAPIPECPIEGERWKEI 525

Query: 1605 RHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYILGIRAAYTK 1426
            RHDNTVTWLAYW+DPIN KEFKYVFLAASSTLKGQSDKEKYEKARLLKDYI GIR AYT+
Sbjct: 526  RHDNTVTWLAYWSDPINGKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYIQGIRTAYTR 585

Query: 1425 DFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNTLKFDF 1246
            DF SKDPAK+QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPN LKFDF
Sbjct: 586  DFVSKDPAKKQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNILKFDF 645

Query: 1245 LGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLKELMPGLTAKVF 1066
            LGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFD+LDTSKLNAHLKELMPGLTAKVF
Sbjct: 646  LGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDKLDTSKLNAHLKELMPGLTAKVF 705

Query: 1065 RTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMLRLNEK 886
            RTYNASITLDD LSRET+GGD+AEKVV Y HANKEVAIICNHQRTVSK+HSAQMLRL+EK
Sbjct: 706  RTYNASITLDDKLSRETKGGDLAEKVVTYNHANKEVAIICNHQRTVSKTHSAQMLRLDEK 765

Query: 885  IEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNLNPDALERKIAQTTAKIEKMERDKE 706
            I+ELKGV+EEL+TDL RA+KGKP L  ADGK KRN+NP+ALERKIAQTTAKIEKMERDKE
Sbjct: 766  IDELKGVLEELKTDLGRARKGKPLLAGADGKAKRNINPEALERKIAQTTAKIEKMERDKE 825

Query: 705  TKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPGFRF 532
            TKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEK+FNKSLL KF+WAMDVDP FRF
Sbjct: 826  TKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKMFNKSLLEKFSWAMDVDPSFRF 883


>emb|CDP13767.1| unnamed protein product [Coffea canephora]
          Length = 926

 Score = 1162 bits (3006), Expect = 0.0
 Identities = 613/927 (66%), Positives = 682/927 (73%), Gaps = 34/927 (3%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDVR 3031
            MAVEAC    L         PLVFKR           SE KK  SQK D Q  R + DV 
Sbjct: 1    MAVEACSTPSLLEDSDEENAPLVFKRTSSSSKQNLSNSETKKLSSQKRDGQSSRNSSDVC 60

Query: 3030 SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 2851
              NGQS+  +  + V  +KTPP K PL+SPK++N S K   + SP  +SKPS+S +    
Sbjct: 61   PVNGQSSSAQTGRVVSSAKTPPAKSPLSSPKAANISAKTSLITSPGANSKPSSSTSATVK 120

Query: 2850 SVKHQ-----IKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTS 2686
             +++      +K  K S  A  + +   +DS+DDKPL A+LP+G S+   NH  K  + S
Sbjct: 121  QLENHKNSPVVKLPKRSVSAA-KLSSTPEDSDDDKPLMAKLPSGSSRAIVNHGNKDGDGS 179

Query: 2685 TLSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTER 2506
            +L QK  +   EDSDDE PLSS++  KSN  ESI++S N GE+K L +K  QNGSA  + 
Sbjct: 180  SLVQKPGVEEDEDSDDEKPLSSRYLSKSNLVESISKSRNPGEKKSLPAKVQQNGSALRDG 239

Query: 2505 ---KPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDED----- 2350
               K S+   KRP   VK++DES +KKPKLS        K+A++KAE + EDD+D     
Sbjct: 240  PVGKSSSLSNKRPPGEVKSSDESAVKKPKLSGPTAAINKKQATLKAEPKVEDDDDDILIS 299

Query: 2349 ---------------------HVPISHRMXXXXXXXXXXXXXKNITKPIXXXXXXXXXXX 2233
                                 HVPI+ RM             K + K +           
Sbjct: 300  QTAKKMFASASKPKSNDDDDDHVPITQRMKKSTTSVSQSSSVKKVAKVVSSSLKKTNKKS 359

Query: 2232 XXXXXXXXXXXXXXXXXXSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQE 2053
                              SGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKG+PV LTPEQE
Sbjct: 360  KKIIKKSKYSKSSKVPPGSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGQPVTLTPEQE 419

Query: 2052 EVATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXX 1873
            EVATM+AVML+TDYM+KP+FKENF +DW++ILGKNHTIQ+LE CDF PIYEWH       
Sbjct: 420  EVATMFAVMLDTDYMSKPQFKENFFSDWKRILGKNHTIQNLEDCDFRPIYEWHQKEKEKK 479

Query: 1872 XXXXXXXXXXXXXXXXXXXXKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKR 1693
                                KYMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKR
Sbjct: 480  KQMTTEEKKSLKEEKLKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKR 539

Query: 1692 IRPSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASST 1513
            IRP DITINIGKDAPIPECPIPGE WKEIRHDNTVTWLA+WNDPINPKEFKYVFLAASST
Sbjct: 540  IRPRDITINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKEFKYVFLAASST 599

Query: 1512 LKGQSDKEKYEKARLLKDYILGIRAAYTKDFTSKDPAKRQIAVATYLIDKLALRAGNEKD 1333
            LKGQSDKEKYEKARLLKDYI GIR AYTKDF SKDP K+QIAVATYLIDKLALRAGNEKD
Sbjct: 600  LKGQSDKEKYEKARLLKDYIHGIRTAYTKDFASKDPMKKQIAVATYLIDKLALRAGNEKD 659

Query: 1332 DDEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKG 1153
            DDEADTVGCCTLKVENVEPVPPN LKFDFLGKDSIRYQNEVEVE+ VFKAIQQFRSGK+G
Sbjct: 660  DDEADTVGCCTLKVENVEPVPPNILKFDFLGKDSIRYQNEVEVESGVFKAIQQFRSGKEG 719

Query: 1152 GDDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQH 973
             +DLFD+LDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSR+T GGDV EKVVVYQ 
Sbjct: 720  SEDLFDKLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRKTNGGDVLEKVVVYQQ 779

Query: 972  ANKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGK 793
            ANKEVAIICNHQRTVSK+HSAQM RLNEKIEELKGV+EEL+TDL+RAKKGKPPLK+ADGK
Sbjct: 780  ANKEVAIICNHQRTVSKTHSAQMSRLNEKIEELKGVLEELKTDLSRAKKGKPPLKNADGK 839

Query: 792  PKRNLNPDALERKIAQTTAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHE 613
            PKRNLNP+ALERKIAQT AKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHE
Sbjct: 840  PKRNLNPEALERKIAQTNAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHE 899

Query: 612  VPIEKIFNKSLLAKFAWAMDVDPGFRF 532
            VPIEKIFNKSLLAKFAW+MDVDP FRF
Sbjct: 900  VPIEKIFNKSLLAKFAWSMDVDPSFRF 926


>dbj|BAG31376.1| topoisomerase I [Camptotheca acuminata]
          Length = 894

 Score = 1141 bits (2952), Expect = 0.0
 Identities = 605/903 (66%), Positives = 680/903 (75%), Gaps = 10/903 (1%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDVR 3031
            MAV+AC K+K+        EPLVFKR           S+ KKS SQ++D Q GR   DV 
Sbjct: 1    MAVQACVKEKMMDEIDEDDEPLVFKRSNATSKHNQLNSDTKKS-SQRYDGQSGRQVSDVP 59

Query: 3030 SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 2851
            S NGQS+   K KT  LS    +K P+ SPK+S +  KA  + +P+V S  S+    K +
Sbjct: 60   STNGQSSSASKGKTTKLSS---MKSPIASPKASTSFAKASPVANPKVSS--SSDDRSKHS 114

Query: 2850 SVKHQIKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTSTLSQK 2671
            S ++ I   K   E      E   DSED+KPLSARL  GL+K +SN+A K    S+ +  
Sbjct: 115  SKQNTINVVKEEKELVNPAAEPYGDSEDEKPLSARLFTGLTKGSSNNANKGLINSSPAS- 173

Query: 2670 RRIPIP--------EDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSAS 2515
              +P+P        +DSDDEIPLSSKF++K+NAG S  +S  S + K L+S + QNGS +
Sbjct: 174  --LPVPKPEINRYSDDSDDEIPLSSKFRLKANAGTSTVKSYESDDNKTLVSNFQQNGSIN 231

Query: 2514 TERKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREED-DEDHVPI 2338
               K S  + KRP   VK++ +S +KKPKLS+A+TP  NK+AS KAE + +D D+DHVPI
Sbjct: 232  RGSKSSIKVNKRPLGEVKSSVQSSVKKPKLSDASTPVNNKQASKKAEPKADDSDDDHVPI 291

Query: 2337 SHRMXXXXXXXXXXXXXKN-ITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSGEGQK 2161
            S RM             K  +TK +                             SGEG+K
Sbjct: 292  SQRMKKSATSGNKSSTAKQKVTKVVSSSMKKASKKFKKVVKKSKYSKSSKVPPSSGEGKK 351

Query: 2160 WTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKPKFKENF 1981
            W TLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATM+AVML+TDYM K KFKENF
Sbjct: 352  WNTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMTKSKFKENF 411

Query: 1980 MADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXXXXKYMW 1801
            M DWRKILGKNH IQ+LE CDFTPIYEWH                           KYMW
Sbjct: 412  MDDWRKILGKNHVIQNLEDCDFTPIYEWHQREKEKKKKMTAEEKKVLKEERLKQEEKYMW 471

Query: 1800 AIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGE 1621
            AIVNGVKEKVGNFRVEPP LFRGRGEHPKMGKLKK IRPSDITINIGKDAPIPECPIPGE
Sbjct: 472  AIVNGVKEKVGNFRVEPPSLFRGRGEHPKMGKLKKCIRPSDITINIGKDAPIPECPIPGE 531

Query: 1620 SWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYILGIR 1441
            SWKEIRHDNTVTWLA+WNDPI P+EFKYVFLAASS+LKGQSDKEKYEKARLLKD+I GIR
Sbjct: 532  SWKEIRHDNTVTWLAFWNDPIKPREFKYVFLAASSSLKGQSDKEKYEKARLLKDFIQGIR 591

Query: 1440 AAYTKDFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNT 1261
            AAYTKDF SKD  KRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEP PP+ 
Sbjct: 592  AAYTKDFASKDITKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPKPPSI 651

Query: 1260 LKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLKELMPGL 1081
            LKFDFLGKDSIRYQNEVEVE  V+KAIQQFR+GK+GGDDLFD+LDTSKLNAHLK LMPGL
Sbjct: 652  LKFDFLGKDSIRYQNEVEVELPVYKAIQQFRTGKRGGDDLFDKLDTSKLNAHLKGLMPGL 711

Query: 1080 TAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQML 901
            TAKVFRTYNASITLD+MLSRET+GG+VAEK+VVYQHANKEVAIICNHQRTVSKSH AQM 
Sbjct: 712  TAKVFRTYNASITLDEMLSRETKGGNVAEKIVVYQHANKEVAIICNHQRTVSKSHPAQMT 771

Query: 900  RLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNLNPDALERKIAQTTAKIEKM 721
            RLN KI+ELKG+++ LQTDLARAKKGKPPL+ ADGKPKRNL P+ALERKI QT AKIEKM
Sbjct: 772  RLNGKIDELKGILDGLQTDLARAKKGKPPLEDADGKPKRNLTPEALERKIGQTNAKIEKM 831

Query: 720  ERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPG 541
            ERDKETKE LKT+ALGTSKI+YLDPRITVAWCKRHEVPIEK+FNKSLLAKFAW+MDVDP 
Sbjct: 832  ERDKETKEGLKTIALGTSKISYLDPRITVAWCKRHEVPIEKVFNKSLLAKFAWSMDVDPS 891

Query: 540  FRF 532
            FRF
Sbjct: 892  FRF 894


>dbj|BAG31377.1| topoisomerase I [Catharanthus roseus]
          Length = 910

 Score = 1129 bits (2921), Expect = 0.0
 Identities = 605/919 (65%), Positives = 667/919 (72%), Gaps = 26/919 (2%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDVR 3031
            MAVEAC    L        EP+VFKR           SE +K  SQK D Q  R   D R
Sbjct: 1    MAVEACPTPNLRDDMDEDDEPIVFKRNNSASKQSQTNSETRKVSSQKRDGQSVRQIYDSR 60

Query: 3030 SQNGQSTIVKKSKTVPLSK---------TPP-----VKYPLTSPKSSNTSGKALALKSPE 2893
              NG+S+  +K + VP SK         +PP     VK PL+SPK S +S K   + S  
Sbjct: 61   PANGESSSGQKGRMVPPSKPSQVKSPLSSPPSKPSQVKSPLSSPKVSTSSAKKSPVSSLP 120

Query: 2892 VDSKPSTSVTDKSNSVKHQ-----IKDEKLST-EATGEPNEDSQDSEDDKPLSARLPAGL 2731
             +SKPSTS + K            IK+EK S          DS+DS+D KPLS R  A  
Sbjct: 121  ANSKPSTSGSFKVKPFNQHKSATVIKEEKSSPLRLASAIINDSEDSDDGKPLSLRHSASS 180

Query: 2730 SKVNSNHAKKSPNTSTLSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKP 2551
            SK N+N   K  +          P  EDSDDE PLSS+F +KS  GES +++ +S + KP
Sbjct: 181  SKGNTNQVSKEGSK---------PENEDSDDEKPLSSRFPLKSGVGESTSKAYDSDDDKP 231

Query: 2550 LLSKYDQNGSASTERKP---STNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIK 2380
            L  K   NGSA  + +P   S    KRP   +K++++  +KKPKLS    P   K+AS+K
Sbjct: 232  LAKKLQHNGSAMRDGQPNKYSNMSNKRPPGDIKSSNQLSVKKPKLSSVTAPTNKKQASVK 291

Query: 2379 AEMR-EEDDEDHVPISHRMXXXXXXXXXXXXXKNITKPIXXXXXXXXXXXXXXXXXXXXX 2203
             E + E+DD+DH+PIS R+             K  TK +                     
Sbjct: 292  PEPKAEDDDDDHLPISQRIKKSPTSESKSSSIKKTTKVVSSSVKKVNKKSKKVMKNSKYS 351

Query: 2202 XXXXXXXXSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVML 2023
                    SGEG+KW  L HNGVIFPPPYKPHG+KMLYKGKPVDLTPEQEEVATM+AVML
Sbjct: 352  KSSKVPPSSGEGKKWNKLEHNGVIFPPPYKPHGIKMLYKGKPVDLTPEQEEVATMFAVML 411

Query: 2022 ETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXX 1843
            +TDYMNKP+FKENF  DW+KILGKNH IQ+LE+CDF+PIYEWH                 
Sbjct: 412  DTDYMNKPRFKENFFGDWKKILGKNHVIQNLENCDFSPIYEWHQSEKEKKKQMTTEEKKA 471

Query: 1842 XXXXXXXXXXKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINI 1663
                      KYMWA V+G KEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRP DITINI
Sbjct: 472  LKEEKLKQEEKYMWAWVDGKKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPCDITINI 531

Query: 1662 GKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKY 1483
            GKDAPIPECP+PGE WKE+RHDNTVTWLA+WNDPINPKEFKYVFLAASSTLKG SDKEKY
Sbjct: 532  GKDAPIPECPVPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSTLKGLSDKEKY 591

Query: 1482 EKARLLKDYILGIRAAYTKDFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCC 1303
            EKARLLKDYI GIRAAYTKDF SKDP K+QIAVATYLIDKLALRAGNEKDDDEADTVGCC
Sbjct: 592  EKARLLKDYIQGIRAAYTKDFASKDPTKKQIAVATYLIDKLALRAGNEKDDDEADTVGCC 651

Query: 1302 TLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDT 1123
            TLKVENVEPVPPN LKFDFLGKDSIRYQNEVEVE AVFKAIQQFRSGK+G  DLFD LDT
Sbjct: 652  TLKVENVEPVPPNILKFDFLGKDSIRYQNEVEVEAAVFKAIQQFRSGKEGSSDLFDLLDT 711

Query: 1122 SKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICN 943
            SKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRET+GGDVAEKVVVYQHANKEVAIICN
Sbjct: 712  SKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETKGGDVAEKVVVYQHANKEVAIICN 771

Query: 942  HQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKS--ADGKPKRNLNPD 769
            HQRTVSKSHSAQMLRLNEKIEELK VVEEL++DL+R KKGKPPLKS  ADGKPKRNLNP+
Sbjct: 772  HQRTVSKSHSAQMLRLNEKIEELKAVVEELKSDLSRVKKGKPPLKSKNADGKPKRNLNPE 831

Query: 768  ALERKIAQTTAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFN 589
            +LE+KIAQT AKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFN
Sbjct: 832  SLEKKIAQTNAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFN 891

Query: 588  KSLLAKFAWAMDVDPGFRF 532
            KSLLAKF WAMDVDP FRF
Sbjct: 892  KSLLAKFTWAMDVDPSFRF 910


>dbj|BAK32960.1| topoisomerase I [Ophiorrhiza pseudofasciculata]
          Length = 925

 Score = 1122 bits (2901), Expect = 0.0
 Identities = 598/926 (64%), Positives = 667/926 (72%), Gaps = 33/926 (3%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDVR 3031
            MAVEAC    L         P++FKR           SE KK   QK D Q      DVR
Sbjct: 1    MAVEACTTN-LMEDMEDDGGPVIFKRSKPAPKQNQANSEKKKLSLQKQDGQSAVHTSDVR 59

Query: 3030 SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 2851
              NG+S+  +K +  P +KTPPVK PL+SPK+SN+S KA  + SP  +SKPS S T  + 
Sbjct: 60   PANGESSSAQKGRIQPSAKTPPVKSPLSSPKASNSSAKASPITSPGANSKPSASATSTAK 119

Query: 2850 SVKHQIKD----EKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTST 2683
               H        E   +    + N +S+ S+D+KPLSAR     SK  SNHA K    S 
Sbjct: 120  QQNHHKSSAAFIEPKPSVPAAKANSNSESSDDEKPLSARTFGCSSKGKSNHANKEGGDSC 179

Query: 2682 LSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE-- 2509
              ++  I   EDS+DE PLS +F  KS+ GES ++S +S E+KPL +K  QNGSAS +  
Sbjct: 180  SIRRPVIEESEDSEDEKPLSCRFTSKSSLGESTSKSYDSDEKKPLAAKVQQNGSASRDGP 239

Query: 2508 -RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDE------- 2353
              K ++   KRP    K+ ++S +KKPKLS   T   NK+A++K E + EDD+       
Sbjct: 240  MNKSASLSNKRPPGEAKSLNQSSVKKPKLSSPITSISNKQAAVKPEPKAEDDDDNIPLSQ 299

Query: 2352 -----------------DHVPISHRMXXXXXXXXXXXXXKN-ITKPIXXXXXXXXXXXXX 2227
                             D+VPIS R+                 +  +             
Sbjct: 300  RGKKSQSATSKPKDDDDDNVPISQRIKKSPASVSKSSVPVKKASTVVSSSLKKVNKNSKK 359

Query: 2226 XXXXXXXXXXXXXXXXSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEV 2047
                            SGEGQKWTTLVHNGVIFPPPYKPHGVKMLYK +P+ LTPEQEEV
Sbjct: 360  VIKKTAYTKSSKVPPGSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKRQPITLTPEQEEV 419

Query: 2046 ATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXX 1867
            ATM+AVML+TDYMNKP FKENF +DW+KILGKNH IQ+LE CDF PIYEWH         
Sbjct: 420  ATMFAVMLDTDYMNKPCFKENFFSDWKKILGKNHMIQNLEDCDFGPIYEWHQQEKEKKKQ 479

Query: 1866 XXXXXXXXXXXXXXXXXXKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR 1687
                              KYMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR
Sbjct: 480  MTTEEKKALKEEKLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR 539

Query: 1686 PSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLK 1507
            P DITINIGKDAPIPECPIPGE WKE+R+ NTVTWLAYWNDPIN KEFKYVFLAASSTLK
Sbjct: 540  PRDITINIGKDAPIPECPIPGERWKEVRNGNTVTWLAYWNDPINQKEFKYVFLAASSTLK 599

Query: 1506 GQSDKEKYEKARLLKDYILGIRAAYTKDFTS-KDPAKRQIAVATYLIDKLALRAGNEKDD 1330
            GQSDKEKYEKARLLKDYI GIRAAYTKDFT+ KDP K+QIAVATYLIDKLALRAGNEKDD
Sbjct: 600  GQSDKEKYEKARLLKDYIHGIRAAYTKDFTNNKDPMKKQIAVATYLIDKLALRAGNEKDD 659

Query: 1329 DEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGG 1150
            DEADTVGCCTLKVENVEPVPPN LKFDFLGKDSIRYQNEV+VE AVFKAIQQFRSGK+G 
Sbjct: 660  DEADTVGCCTLKVENVEPVPPNILKFDFLGKDSIRYQNEVQVEPAVFKAIQQFRSGKEGS 719

Query: 1149 DDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHA 970
            +DLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLS+ET+GG+VAE VVVYQHA
Sbjct: 720  EDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKETKGGEVAENVVVYQHA 779

Query: 969  NKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGKP 790
            NKEVAIICNHQRTVSKSHSAQM RLNEKI+ELK  +EEL+TDL+RAKKGKPP K ADGK 
Sbjct: 780  NKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTALEELKTDLSRAKKGKPPTKGADGKA 839

Query: 789  KRNLNPDALERKIAQTTAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEV 610
            KRNLNP+ALERKI QT AKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEV
Sbjct: 840  KRNLNPEALERKITQTNAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEV 899

Query: 609  PIEKIFNKSLLAKFAWAMDVDPGFRF 532
            PIEKIFNKSLLAKFAW+MDVDP FRF
Sbjct: 900  PIEKIFNKSLLAKFAWSMDVDPSFRF 925


>dbj|BAG31375.1| topoisomerase I [Ophiorrhiza japonica]
          Length = 927

 Score = 1119 bits (2895), Expect = 0.0
 Identities = 594/928 (64%), Positives = 670/928 (72%), Gaps = 35/928 (3%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDVR 3031
            MAVEAC    L         P++FKR           SE KK   QKH  Q      DVR
Sbjct: 1    MAVEACTPN-LMEDMEDDEGPVIFKRSNPASKQNQANSEKKKLSLQKHVGQSAVHTSDVR 59

Query: 3030 SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 2851
              NG+S+  +K +  P +KTPPVK PL+SPK+SN+S KA  + SP  +SKPS S T  + 
Sbjct: 60   PANGESSSAQKGRIQPSAKTPPVKSPLSSPKASNSSAKASPITSPGANSKPSASATSTAK 119

Query: 2850 SVKHQIKD----EKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTST 2683
               H        E   +    + N +S+ S+D+KPLSAR     SK  SNHA K    S 
Sbjct: 120  QQNHHKSSAAFIEPKPSVPAAKANSNSESSDDEKPLSARTFGCSSKGKSNHANKEGGDSC 179

Query: 2682 LSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE-- 2509
              ++R I   EDS+DE PLS +F  KS+ GES ++S +S E+KPL +K  QNGS S +  
Sbjct: 180  SIRRRVIEESEDSEDEKPLSRRFTSKSSLGESTSKSYDSDEKKPLAAKVQQNGSVSRDGP 239

Query: 2508 -RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMR------------ 2368
              K ++   KRP   VK+ ++S +KKPKLS   T   NK+A++K E              
Sbjct: 240  MNKSASLSNKRPPGEVKSLNQSSVKKPKLSSPITSISNKQAAVKPEPEPKAEDDDDNIPL 299

Query: 2367 --------------EEDDEDHVPISHRMXXXXXXXXXXXXXKN-ITKPIXXXXXXXXXXX 2233
                          +++D+D+VPI+ R+                 +  +           
Sbjct: 300  SQRGKKSQAATSKPKDEDDDNVPIAQRIKKSPASVSKSSAPVKKASTVVSPSLKKVNKNS 359

Query: 2232 XXXXXXXXXXXXXXXXXXSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQE 2053
                              SGEGQKWTTLVHNGVIFPPPY PHGVKMLYK +P+ LTPEQE
Sbjct: 360  KKVIKKTAYTKSSKVPPGSGEGQKWTTLVHNGVIFPPPYNPHGVKMLYKRQPITLTPEQE 419

Query: 2052 EVATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXX 1873
            EVATM+AVML+TDYMNKP+FKENF +DW+K+LGKNHTIQ+LE CDF PIYEWH       
Sbjct: 420  EVATMFAVMLDTDYMNKPRFKENFFSDWKKMLGKNHTIQNLEDCDFGPIYEWHQQEKEKK 479

Query: 1872 XXXXXXXXXXXXXXXXXXXXKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKR 1693
                                KYMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKR
Sbjct: 480  KQMTTEEKKALKEDKLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKR 539

Query: 1692 IRPSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASST 1513
            IRP DITINIGKDAPIPECPIPGE WKE+R+DNTVTWLA+W DPIN KEFKYVFLAASST
Sbjct: 540  IRPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAFWIDPINQKEFKYVFLAASST 599

Query: 1512 LKGQSDKEKYEKARLLKDYILGIRAAYTKDFTS-KDPAKRQIAVATYLIDKLALRAGNEK 1336
            LKGQSDKEKYEKARLLKDYI GIRAAYTKDFT+ KDP K+QIAVATYLIDKLALRAGNEK
Sbjct: 600  LKGQSDKEKYEKARLLKDYIHGIRAAYTKDFTNNKDPMKKQIAVATYLIDKLALRAGNEK 659

Query: 1335 DDDEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKK 1156
            DDDEADTVGCCTLKVENVEPVPPN LKFDFLGKDSIRYQNEV+VE AVFKAIQQFRSGK+
Sbjct: 660  DDDEADTVGCCTLKVENVEPVPPNILKFDFLGKDSIRYQNEVQVEPAVFKAIQQFRSGKE 719

Query: 1155 GGDDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQ 976
            G +DLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLS+ET+GG+VAEKVVVYQ
Sbjct: 720  GSEDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKETKGGEVAEKVVVYQ 779

Query: 975  HANKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADG 796
            HANKEVAIICNHQRTVSKSHSAQM RLNEKI+ELK  +EEL+TDL+R KKGKPP K ADG
Sbjct: 780  HANKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTAMEELKTDLSRVKKGKPPSKGADG 839

Query: 795  KPKRNLNPDALERKIAQTTAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRH 616
            KPKRNLNP+ALERK+AQ  AKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRH
Sbjct: 840  KPKRNLNPEALERKMAQINAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRH 899

Query: 615  EVPIEKIFNKSLLAKFAWAMDVDPGFRF 532
            EVPIEKIFNKSLLAKFAW+MDVDP FRF
Sbjct: 900  EVPIEKIFNKSLLAKFAWSMDVDPSFRF 927


>dbj|BAK32958.1| topoisomerase I [Ophiorrhiza pedunculata]
          Length = 920

 Score = 1115 bits (2883), Expect = 0.0
 Identities = 593/919 (64%), Positives = 664/919 (72%), Gaps = 33/919 (3%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDVR 3031
            MAVEAC    L         P++FKR           SE KK   QKH  Q      DVR
Sbjct: 1    MAVEACTTTNLMEDMEDDEGPVIFKRSNPASKQNQANSEKKKLSLQKHVGQSAVHTSDVR 60

Query: 3030 SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 2851
              NG+++  +K +  P +KTPPVK PL+SPK+SN+S KA  + SP  +SKPS S T  + 
Sbjct: 61   PANGENSSAQKGRIQPSAKTPPVKSPLSSPKASNSSAKASPITSPGANSKPSASATSTAK 120

Query: 2850 SVKHQIKD----EKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTST 2683
               H        E   +    + N +S+ S+D+KPLSAR     SK  SNHA K    S 
Sbjct: 121  QQNHHKSSAAFIEPKPSVPAAKANSNSESSDDEKPLSARTFGCSSKGKSNHANKEGGDSC 180

Query: 2682 LSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE-- 2509
              ++  I   EDS+DE PLS +F  KS+ GES ++S +S E+KPL +K   NGSAS +  
Sbjct: 181  SIRRPVIEESEDSEDEKPLSRRFTSKSSLGESTSKSYDSDEKKPLAAKVQPNGSASRDSP 240

Query: 2508 -RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDE------- 2353
              K ++   KRP   VK+ ++S LKKPKLS   T   NK+A++K E + EDD+       
Sbjct: 241  MNKSASLSNKRPPGEVKSLNQSSLKKPKLSSPITSISNKQAAVKPEPKAEDDDDNIPLSQ 300

Query: 2352 -----------------DHVPISHRMXXXXXXXXXXXXXKN-ITKPIXXXXXXXXXXXXX 2227
                             D+VPIS R+                 +  +             
Sbjct: 301  RGKKSQTATSKPKDEDDDNVPISQRIKKSPASVSKSSAPVKKASTVVSPSLKKVNKKSKK 360

Query: 2226 XXXXXXXXXXXXXXXXSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEV 2047
                            SGEGQKWTTLVHNGVIFPPPYKPHGVKMLYK +P+ LTPEQEEV
Sbjct: 361  VIKKTAYTKSSKVPPGSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKRQPITLTPEQEEV 420

Query: 2046 ATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXX 1867
            ATM+AVML+TDYMNKP+FKENF +DW+K+LGKNHTIQ+LE CDF PIYEWH         
Sbjct: 421  ATMFAVMLDTDYMNKPRFKENFFSDWKKMLGKNHTIQNLEDCDFGPIYEWHQQEKEKKKQ 480

Query: 1866 XXXXXXXXXXXXXXXXXXKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR 1687
                              KYMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR
Sbjct: 481  MTTEEKKALKEEKLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR 540

Query: 1686 PSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLK 1507
            P DITINIGKDAPIPECPIPGE WKE+R+DNTVTWLAYWNDPIN KEFKYVFLAASSTLK
Sbjct: 541  PRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAYWNDPINQKEFKYVFLAASSTLK 600

Query: 1506 GQSDKEKYEKARLLKDYILGIRAAYTKDFTS-KDPAKRQIAVATYLIDKLALRAGNEKDD 1330
            GQSDKEKYEKARLLKDYI GIRAAYTKDFT+ KDP K+QIAVATYLIDKLALRAGNEKDD
Sbjct: 601  GQSDKEKYEKARLLKDYIHGIRAAYTKDFTNNKDPMKKQIAVATYLIDKLALRAGNEKDD 660

Query: 1329 DEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGG 1150
            DEADTVGCCTLKVENVEPVPPN LKFDFLGKDSIRYQNEV+VE AVFKAI QFRSGK+G 
Sbjct: 661  DEADTVGCCTLKVENVEPVPPNILKFDFLGKDSIRYQNEVQVEPAVFKAIHQFRSGKEGS 720

Query: 1149 DDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHA 970
            +DLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLS++T GG+VAEKVVVYQHA
Sbjct: 721  EDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKKTNGGEVAEKVVVYQHA 780

Query: 969  NKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGKP 790
            NKEVAIICNHQRTVSKSHSAQM RLNEKI+ELK  +EEL+TDL+RAKKGKP  K ADGKP
Sbjct: 781  NKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTALEELKTDLSRAKKGKPLSKGADGKP 840

Query: 789  KRNLNPDALERKIAQTTAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEV 610
            KRNLNP+ALERKIAQT AKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEV
Sbjct: 841  KRNLNPEALERKIAQTNAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEV 900

Query: 609  PIEKIFNKSLLAKFAWAMD 553
            PIEKIFNKSLLAKFAWAM+
Sbjct: 901  PIEKIFNKSLLAKFAWAMN 919


>dbj|BAK32962.1| topoisomerase I [Ophiorrhiza trichocarpon var. glabra]
          Length = 920

 Score = 1112 bits (2877), Expect = 0.0
 Identities = 592/919 (64%), Positives = 664/919 (72%), Gaps = 33/919 (3%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDVR 3031
            MAVEAC    L         P++FKR           SE KK   Q+H  Q      DVR
Sbjct: 1    MAVEACTTTNLMEDMEDDEGPVIFKRSNPASKQNQANSEKKKLSLQRHVGQSAVHTSDVR 60

Query: 3030 SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 2851
              NG+++  +K +  P +KTPPVK PL+SPK+SN+S KA  + S   +SKPS S T  + 
Sbjct: 61   PANGENSSAQKGRIQPSAKTPPVKSPLSSPKASNSSAKASPITSAGANSKPSASATSTAK 120

Query: 2850 SVKHQIKD----EKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTST 2683
               H        E   +    + N +S+ S+D+KPLSAR     SK  SNHA K    S 
Sbjct: 121  QQNHHKSSAAFIEPKPSVPAAKANSNSESSDDEKPLSARTFGCSSKGKSNHANKEGGDSC 180

Query: 2682 LSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE-- 2509
              ++  I   EDS+DE PLS +F  KS+ GES ++S +S E+KPL +K   NGSAS +  
Sbjct: 181  SIRRPVIEESEDSEDEKPLSRRFTSKSSLGESTSKSYDSDEKKPLAAKVQPNGSASRDSP 240

Query: 2508 -RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDE------- 2353
              K ++   KRP   VK+ ++S LKKPKLS   T   NK+A++K E + EDD+       
Sbjct: 241  MNKSASLSNKRPPGEVKSLNQSSLKKPKLSSPITSISNKQAAVKPEPKAEDDDDNIPLSQ 300

Query: 2352 -----------------DHVPISHRMXXXXXXXXXXXXXKN-ITKPIXXXXXXXXXXXXX 2227
                             D+VPIS R+                 +  +             
Sbjct: 301  RGKKSQTATSKPKDEDDDNVPISQRIKKSPASVSKSSAPVKKASTVVSPSLKKVNKKSKK 360

Query: 2226 XXXXXXXXXXXXXXXXSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEV 2047
                            SGEGQKWTTLVHNGVIFPPPYKPHGVKMLYK +P+ LTPEQEEV
Sbjct: 361  VIKKTAYTKSSKVPPGSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKRQPITLTPEQEEV 420

Query: 2046 ATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXX 1867
            ATM+AVML+TDYMNKP+FKENF +DW+K+LGKNHTIQ+LE CDF PIYEWH         
Sbjct: 421  ATMFAVMLDTDYMNKPRFKENFFSDWKKMLGKNHTIQNLEDCDFGPIYEWHQQEKEKKKQ 480

Query: 1866 XXXXXXXXXXXXXXXXXXKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR 1687
                              KYMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR
Sbjct: 481  MTTEEKKALKEEKLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR 540

Query: 1686 PSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLK 1507
            P DITINIGKDAPIPECPIPGE WKE+R+DNTVTWLAYWNDPIN KEFKYVFLAASSTLK
Sbjct: 541  PRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAYWNDPINQKEFKYVFLAASSTLK 600

Query: 1506 GQSDKEKYEKARLLKDYILGIRAAYTKDFTS-KDPAKRQIAVATYLIDKLALRAGNEKDD 1330
            GQSDKEKYEKARLLKDYI GIRAAYTKDFT+ KDP K+QIAVATYLIDKLALRAGNEKDD
Sbjct: 601  GQSDKEKYEKARLLKDYIHGIRAAYTKDFTNNKDPMKKQIAVATYLIDKLALRAGNEKDD 660

Query: 1329 DEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGG 1150
            DEADTVGCCTLKVENVEPVPPN LKFDFLGKDSIRYQNEV+VE AVFKAIQQFRSGK+G 
Sbjct: 661  DEADTVGCCTLKVENVEPVPPNILKFDFLGKDSIRYQNEVQVEPAVFKAIQQFRSGKEGS 720

Query: 1149 DDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHA 970
            +DLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLS++T GG+VAEKVVVYQHA
Sbjct: 721  EDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKKTNGGEVAEKVVVYQHA 780

Query: 969  NKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGKP 790
            NKEVAIICNHQRTVSKSHSAQM RLNEKI+ELK  +EEL+TDL+RAKKGKP  K ADGKP
Sbjct: 781  NKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTALEELKTDLSRAKKGKPLSKGADGKP 840

Query: 789  KRNLNPDALERKIAQTTAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEV 610
            KRNLNP+ALERKIAQT AKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEV
Sbjct: 841  KRNLNPEALERKIAQTNAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEV 900

Query: 609  PIEKIFNKSLLAKFAWAMD 553
            PIEKIFNKSLLAKFAWAM+
Sbjct: 901  PIEKIFNKSLLAKFAWAMN 919


>ref|XP_006364175.2| PREDICTED: DNA topoisomerase 1-like [Solanum tuberosum]
          Length = 905

 Score = 1104 bits (2856), Expect = 0.0
 Identities = 581/918 (63%), Positives = 664/918 (72%), Gaps = 25/918 (2%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXE-PLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDV 3034
            MAVEA  K  L        + PLVFKR                S SQK D + GR  PDV
Sbjct: 1    MAVEAFAKTNLMEDIDDDDDMPLVFKRSSTTSKQ-----NQSNSSSQKQDGRSGRQVPDV 55

Query: 3033 RSQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKAL------------------- 2911
            RS NGQS+   K KT   SK  P   PLTSPK++  S +                     
Sbjct: 56   RSPNGQSSSTHKVKTAASSKASPAVSPLTSPKAAPLSSRTSPAPNFRTSPAPNSRTPPAP 115

Query: 2910 -ALKSPEVDSKPSTSVTDKSNSVKHQI----KDEKLSTEATGEPNEDSQDSEDDKPLSAR 2746
             +  SP  +S+PS+S  +++ +V  Q     K+ K + E   EPN++++DSEDDKPLSAR
Sbjct: 116  NSRTSPAPNSRPSSSAGNQAKNVNQQSNIAPKESKQAIEPKSEPNDEAEDSEDDKPLSAR 175

Query: 2745 LPAGLSKVNSNHAKKSPNTSTLSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNS 2566
            +P+GLSK NS HA     TST  QK R P  EDSDDEIPL+S+FQ+KS+AG S ++ S+S
Sbjct: 176  VPSGLSKSNSIHANNVLGTSTSVQKSRPPKKEDSDDEIPLASRFQMKSSAGASTSKFSSS 235

Query: 2565 GERKPLLSKYDQNGSASTERKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEAS 2386
             E KP   K  QNG  S     +T L KRP   VK+  ++ +KKP+LS+A+TP  +K+ S
Sbjct: 236  EEVKP---KIRQNGLPS-----ATVLSKRPPGEVKSAAQASVKKPRLSDASTPVSSKQPS 287

Query: 2385 IKAEMREEDDEDHVPISHRMXXXXXXXXXXXXXKNITKPIXXXXXXXXXXXXXXXXXXXX 2206
            +K E + EDD+D VP+S R+              +  K                      
Sbjct: 288  VKTEKKTEDDDDEVPLSQRIKKAVASASASASKVSSVKKATKVVSSSMKKTKKKLKKPKY 347

Query: 2205 XXXXXXXXXSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVM 2026
                     SG+GQKWTTL HNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVM
Sbjct: 348  SKSSKLQPSSGDGQKWTTLEHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVM 407

Query: 2025 LETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXX 1846
            L+T+Y+ K +FKENFM DWRKILGKNH IQ LE C+FTPIYEWH                
Sbjct: 408  LDTEYLTKQQFKENFMNDWRKILGKNHVIQKLEECNFTPIYEWHQSEKEKKKQMSSEEKK 467

Query: 1845 XXXXXXXXXXXKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITIN 1666
                       KYMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPKMGKLK+RIRP+DITIN
Sbjct: 468  ALREEKLKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPNDITIN 527

Query: 1665 IGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEK 1486
            IGK  P+PECPIPG+ WKE+RHDNTVTWLA+WNDPINP+EFKYVFLAASS+LKGQSDKEK
Sbjct: 528  IGKGVPVPECPIPGQRWKEVRHDNTVTWLAFWNDPINPREFKYVFLAASSSLKGQSDKEK 587

Query: 1485 YEKARLLKDYILGIRAAYTKDFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGC 1306
            YEKAR LKDYI GIR+AYTKDFTSKDP KRQIAVATYLIDKLALRAGNEKDDDEADTVGC
Sbjct: 588  YEKARRLKDYIEGIRSAYTKDFTSKDPVKRQIAVATYLIDKLALRAGNEKDDDEADTVGC 647

Query: 1305 CTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLD 1126
            CTLKVENVEPVPPN LKFDFLGKDSIRYQNEV V   VFKAIQQFRSGKKGGDDLFD+LD
Sbjct: 648  CTLKVENVEPVPPNILKFDFLGKDSIRYQNEVAVYEPVFKAIQQFRSGKKGGDDLFDKLD 707

Query: 1125 TSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIIC 946
            TSKLNAHLKELMPGLTAKVFRTYNAS TL+  L++ T+GG++A+KV VY  ANKEVAIIC
Sbjct: 708  TSKLNAHLKELMPGLTAKVFRTYNASFTLEQQLTKLTQGGELADKVAVYNVANKEVAIIC 767

Query: 945  NHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNLNPDA 766
            NHQRTVSKSHS Q+ RLNEKI+ELK ++EE + DLARAKKGKPP+K ADGK KRNL P+A
Sbjct: 768  NHQRTVSKSHSVQISRLNEKIDELKAILEEFKVDLARAKKGKPPVKGADGKAKRNLTPEA 827

Query: 765  LERKIAQTTAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNK 586
            L++KI QT  KI+ +ER  ETKE+LKTVALGTSKINYLDPRITVAWCKRHEVPIEK+FNK
Sbjct: 828  LQKKIDQTNVKIDNIERQIETKEELKTVALGTSKINYLDPRITVAWCKRHEVPIEKMFNK 887

Query: 585  SLLAKFAWAMDVDPGFRF 532
            SLLAKFAWAMDV+P F F
Sbjct: 888  SLLAKFAWAMDVEPSFTF 905


>gb|KHG20024.1| DNA topoisomerase 1 -like protein [Gossypium arboreum]
          Length = 903

 Score = 1102 bits (2849), Expect = 0.0
 Identities = 579/911 (63%), Positives = 668/911 (73%), Gaps = 18/911 (1%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXS-EAKKSLSQKHDRQLGRPAPDV 3034
            MAVEA  K            P+VFKR           + E KK+ SQ+ D Q GR A  V
Sbjct: 1    MAVEAPSKHVFDYDDEDDDGPVVFKRSNTSSSKQNQLNSEVKKASSQRSDGQSGRQASSV 60

Query: 3033 RSQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKS 2854
            R+ NGQ+++ + +K++P SK+PP++ P+ SPKSSN+S KA  ++SP V SK STS  D+S
Sbjct: 61   RAPNGQNSVAQTNKSIPPSKSPPIRSPILSPKSSNSSSKASPVRSPVVSSKASTSFNDQS 120

Query: 2853 NSVKHQ-----IKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNT 2689
                 Q     +K+EK   + T E N D  D +D KPLSARL     K  S+   K  +T
Sbjct: 121  KQASKQNKFTAVKEEKSPIKRTDETNSDDDDDDDSKPLSARL-----KGISSQGNKGVST 175

Query: 2688 STLSQKRRIPIP--------EDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYD 2533
            ST +Q +R  +P        ED DD+ PLS++F  KSN G S ++   S E+KPL SK  
Sbjct: 176  STPAQSQRF-VPKIEVKGSAEDPDDDAPLSARFSTKSNTGTSSSKPYGSHEKKPLASKIQ 234

Query: 2532 QNGSAST--ERKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREED 2359
            QNGS     ++K S    KRP D   ++D+SY KKPK+S+  T  K K+ ++KAE  ++D
Sbjct: 235  QNGSIMKVKQQKSSMLSDKRPLDKGNSSDQSYAKKPKISDTPTMMKTKQVTVKAE--KDD 292

Query: 2358 DEDHVPISHRMXXXXXXXXXXXXXKN-ITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXX 2182
            ++DH+PIS R+             K   TK +                            
Sbjct: 293  EDDHIPISQRIKKSVSSVSKASSVKQKATKVVSSSFKKINKKSKKDMKKSKYSKSTKLSP 352

Query: 2181 XSGEGQK-WTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMN 2005
             SG+GQK W+TLVHNGVIFPPPYKPHGVKMLY G+PVDLTPEQEEVATM+AVM ETDYM+
Sbjct: 353  SSGDGQKKWSTLVHNGVIFPPPYKPHGVKMLYDGRPVDLTPEQEEVATMFAVMQETDYMS 412

Query: 2004 KPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXX 1825
            KP+FK+NF  DW K+LG+NH I+SL+ CDFTPIYEWH                       
Sbjct: 413  KPQFKKNFWEDWSKLLGRNHVIKSLDKCDFTPIYEWHLQEKEKKKQMSSEEKKALKEEKL 472

Query: 1824 XXXXKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPI 1645
                KYMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPKMGKLK+RIRP DITINIGKDAPI
Sbjct: 473  MQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPCDITINIGKDAPI 532

Query: 1644 PECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLL 1465
            PECPIPGE WK+I+HDNTVTWLA+WNDPINPKEFKYVFLAASS+LKGQSDKEKYEKARLL
Sbjct: 533  PECPIPGERWKDIKHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARLL 592

Query: 1464 KDYILGIRAAYTKDFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVEN 1285
            KDYI  IRAAYTKDFT+KD  KRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKV N
Sbjct: 593  KDYIKNIRAAYTKDFTAKDVTKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVGN 652

Query: 1284 VEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAH 1105
            VE +PPN LKFDFLGKDSI+Y N VEVE  V+KAI QF++GK   DDLFD LDTSKLNAH
Sbjct: 653  VECIPPNKLKFDFLGKDSIQYVNTVEVELPVYKAIGQFQTGKSKSDDLFDELDTSKLNAH 712

Query: 1104 LKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVS 925
            LKELMPGLTAKVFRT+NASITLDDML++ET+ GDVAEKVV+YQ ANKEVAIICNHQR++S
Sbjct: 713  LKELMPGLTAKVFRTFNASITLDDMLNKETKDGDVAEKVVIYQRANKEVAIICNHQRSIS 772

Query: 924  KSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNLNPDALERKIAQ 745
            KSHSAQM RL EKI ELKG+V+EL+TDL RAKKGKPPLK ADGK KRNL P+A+E+KIAQ
Sbjct: 773  KSHSAQMSRLTEKINELKGLVKELKTDLDRAKKGKPPLKDADGKQKRNLTPEAIEKKIAQ 832

Query: 744  TTAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFA 565
            T  KIEKMERD +TKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFA
Sbjct: 833  TNVKIEKMERDMQTKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFA 892

Query: 564  WAMDVDPGFRF 532
            WAMDVDP FRF
Sbjct: 893  WAMDVDPDFRF 903


>dbj|BAK32961.1| topoisomerase I [Ophiorrhiza ridleyana]
          Length = 926

 Score = 1099 bits (2842), Expect = 0.0
 Identities = 583/927 (62%), Positives = 663/927 (71%), Gaps = 34/927 (3%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDVR 3031
            MAVEAC    L         P++FKR           +E KK   QKH  Q      DVR
Sbjct: 1    MAVEACTTTNLMEDMEDDEGPVIFKRSNPTSKQNQANAEKKKLSLQKHVGQSAVHTSDVR 60

Query: 3030 SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 2851
              NG+S+  +K +  P ++TPPVK PL+SPK+SN+S KA  + SP  +SK S S T  + 
Sbjct: 61   PANGESSSAQKGRIQPSAETPPVKSPLSSPKASNSSAKASPITSPGANSKLSASATSTAK 120

Query: 2850 SVKHQIKD----EKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTST 2683
               H        E   +    + N +S+ S+D+KPL AR     S   SNHA K    S 
Sbjct: 121  QQNHHKSSAAFIEPKPSVPAAKANSNSESSDDEKPLIARTSGCSSMGKSNHANKEGGDSC 180

Query: 2682 LSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE-- 2509
              ++  I   EDS+DE PLS +F  KS+ GES ++S +S E+KPL +K  QNGSAS E  
Sbjct: 181  SIRRPVIEESEDSEDEKPLSRRFPSKSSLGESTSKSYDSDEKKPLAAKVQQNGSASPEGP 240

Query: 2508 --RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDED----- 2350
              +  S + K+ PG+ VK+ ++S LKKPKLS   T   NK+A++K E + EDD+D     
Sbjct: 241  MNKSASLSNKRAPGE-VKSLNQSSLKKPKLSSPITSISNKQAAVKPEPKAEDDDDNIPLS 299

Query: 2349 -------------------HVPISHRMXXXXXXXXXXXXXKN-ITKPIXXXXXXXXXXXX 2230
                               H PIS R+                 +  +            
Sbjct: 300  QRGKKSQTAASKPKDEDDDHAPISQRIKKSPVSVSKSSAPVKKASTVVSTSLKKVNKKSK 359

Query: 2229 XXXXXXXXXXXXXXXXXSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEE 2050
                             SGEGQKWTTLVHNGV+FPPPYKPHGVKMLYK +P+ LTPEQEE
Sbjct: 360  KVIRKTAYTKSSKVPPGSGEGQKWTTLVHNGVMFPPPYKPHGVKMLYKRQPLTLTPEQEE 419

Query: 2049 VATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXX 1870
            VATM+AVML+TDYMNKP+FKENF +DW+KILGKNHTIQ+LE CDF PIYEWH        
Sbjct: 420  VATMFAVMLDTDYMNKPRFKENFFSDWKKILGKNHTIQNLEDCDFGPIYEWHQQEKEKKK 479

Query: 1869 XXXXXXXXXXXXXXXXXXXKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRI 1690
                               KYMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPK+GKLKKRI
Sbjct: 480  QMTTEEKKALKEERLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKVGKLKKRI 539

Query: 1689 RPSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTL 1510
            RP DITINIGKDAPIPECPIPGE WKE+R+DNTVTWLAYWNDP+N KE KYVFLAASSTL
Sbjct: 540  RPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAYWNDPVNIKECKYVFLAASSTL 599

Query: 1509 KGQSDKEKYEKARLLKDYILGIRAAYTKDFTS-KDPAKRQIAVATYLIDKLALRAGNEKD 1333
            KGQS KEKYEKAR+LKDYI GIRAAYTK FT+ KDP K+QIAVATYLIDKLALRAGNEKD
Sbjct: 600  KGQSVKEKYEKARVLKDYIHGIRAAYTKGFTNNKDPMKKQIAVATYLIDKLALRAGNEKD 659

Query: 1332 DDEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKG 1153
            DDEADTVGCCTLKVENVEPVPPN LK DF+GKDSIRYQNEV+VE AVFKAIQQFRSGK+G
Sbjct: 660  DDEADTVGCCTLKVENVEPVPPNILKIDFIGKDSIRYQNEVQVEPAVFKAIQQFRSGKEG 719

Query: 1152 GDDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQH 973
             +DLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLS+ET+GG +AEKV VYQH
Sbjct: 720  SEDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKETKGGKIAEKVAVYQH 779

Query: 972  ANKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGK 793
            ANKEVAIICNHQRTVSKSHSAQM RLNEKI+ELK  +EEL+TDL+RAKKGKPP K ADG+
Sbjct: 780  ANKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTALEELKTDLSRAKKGKPPSKDADGE 839

Query: 792  PKRNLNPDALERKIAQTTAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHE 613
            PKRNLNP++LERKIAQT AKIEKMERDK+TKEDLK VAL TSKI+YLDPRITVAWCKR E
Sbjct: 840  PKRNLNPESLERKIAQTNAKIEKMERDKKTKEDLKAVALSTSKISYLDPRITVAWCKRQE 899

Query: 612  VPIEKIFNKSLLAKFAWAMDVDPGFRF 532
            VPIEK+FNKSLLAKFAWAMDVDP FRF
Sbjct: 900  VPIEKMFNKSLLAKFAWAMDVDPSFRF 926


>dbj|BAG31373.1| topoisomerase I [Ophiorrhiza pumila]
          Length = 926

 Score = 1098 bits (2841), Expect = 0.0
 Identities = 584/927 (62%), Positives = 663/927 (71%), Gaps = 34/927 (3%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDVR 3031
            MAVEAC    L         P++FKR           SE KK   QKH  Q      DVR
Sbjct: 1    MAVEACTTPNLMEDMEDDEGPVIFKRSNPASKQNQANSEKKKLSLQKHVGQSAVHTSDVR 60

Query: 3030 SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 2851
              NG+S+  +K +  P ++TPPVK PL+SPK+SN+S KA  + SP  +SK S S T  + 
Sbjct: 61   PANGESSSAQKGRIQPSAETPPVKSPLSSPKASNSSAKASPITSPGANSKLSASATSTAK 120

Query: 2850 SVKHQIKD----EKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTST 2683
               H        E   +    + N +S+ S+D+KPL AR     SK  SNHA K    S 
Sbjct: 121  QQNHHKSSAAFIEPKPSVPAAKANSNSESSDDEKPLIARTSGCSSKGKSNHANKEGGDSC 180

Query: 2682 LSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE-- 2509
              ++  I   EDS+DE PLS +F  KS+ GES ++S +S E+KPL +K  QNGSAS +  
Sbjct: 181  SIRRPVIEESEDSEDEKPLSRRFPSKSSLGESTSKSHDSDEKKPLAAKVQQNGSASRDGP 240

Query: 2508 --RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDE------ 2353
              +  S + K+ PG+ VK+ ++S LKKPKLS   T   NK+A++K E + EDD+      
Sbjct: 241  MNKSASLSNKRAPGE-VKSLNQSSLKKPKLSSTITSISNKQAAVKPEPKAEDDDDNIPLS 299

Query: 2352 ------------------DHVPISHRMXXXXXXXXXXXXXKN-ITKPIXXXXXXXXXXXX 2230
                              D+ PIS R+                 +  +            
Sbjct: 300  QRGKKSQTAASKPKDEDDDNAPISQRIKKSPASVSKSSAPVKKASTVVSPSLKKVNKKSK 359

Query: 2229 XXXXXXXXXXXXXXXXXSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEE 2050
                             SGEGQKWTTLVHNGV+FPPPYKPHGVKMLYK +P+ LTPEQEE
Sbjct: 360  KVIKKTAYTKSSKVPPGSGEGQKWTTLVHNGVMFPPPYKPHGVKMLYKRQPLTLTPEQEE 419

Query: 2049 VATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXX 1870
            VATM+A ML+TDYMNKP+FKENF +DW+KILGKNHTIQ+LE CDF PIYEWH        
Sbjct: 420  VATMFAAMLDTDYMNKPRFKENFFSDWKKILGKNHTIQNLEDCDFGPIYEWHQQEKEKKK 479

Query: 1869 XXXXXXXXXXXXXXXXXXXKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRI 1690
                               KYMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPK+GKLKKRI
Sbjct: 480  QMTTEEKKALKEERLQLEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKVGKLKKRI 539

Query: 1689 RPSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTL 1510
            RP DITINIGKDAPIPECPIPGE WKE+R+DNTVTWLAYWNDP+N KE KYVFLAASSTL
Sbjct: 540  RPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAYWNDPVNLKECKYVFLAASSTL 599

Query: 1509 KGQSDKEKYEKARLLKDYILGIRAAYTKDFTS-KDPAKRQIAVATYLIDKLALRAGNEKD 1333
            KGQSDKEKYEKARLLKDYI GIRAAYTKDFT+ KDP K+Q+AVATYLIDKLALRAGNEKD
Sbjct: 600  KGQSDKEKYEKARLLKDYIHGIRAAYTKDFTNNKDPMKKQVAVATYLIDKLALRAGNEKD 659

Query: 1332 DDEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKG 1153
            DDEADTVGCCTLKVENVEPVPPN LK DF+GKDSIRYQNEV+VE AVFKAIQQFRSGK+G
Sbjct: 660  DDEADTVGCCTLKVENVEPVPPNILKIDFIGKDSIRYQNEVQVEPAVFKAIQQFRSGKEG 719

Query: 1152 GDDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQH 973
             +DLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLS+ET+GG VAEKV VYQ 
Sbjct: 720  SEDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKETKGGKVAEKVGVYQR 779

Query: 972  ANKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGK 793
            ANKEVAIICNHQRTVSKSHSAQM RLNEKI+ELK  +EEL+TDL+RAKKGKPP K  DG+
Sbjct: 780  ANKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTALEELKTDLSRAKKGKPPSKGDDGE 839

Query: 792  PKRNLNPDALERKIAQTTAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHE 613
            PKRNLNP+ALERKIAQT AKIEKMERDK+TKEDLK VAL TSKI+YLDPRITVAWCKR E
Sbjct: 840  PKRNLNPEALERKIAQTNAKIEKMERDKKTKEDLKAVALSTSKISYLDPRITVAWCKRQE 899

Query: 612  VPIEKIFNKSLLAKFAWAMDVDPGFRF 532
            VPIEK+FNKSLLAKFAWAMDVDP FRF
Sbjct: 900  VPIEKMFNKSLLAKFAWAMDVDPSFRF 926


>dbj|BAK32956.1| topoisomerase I [Ophiorrhiza fucosa]
          Length = 926

 Score = 1097 bits (2836), Expect = 0.0
 Identities = 583/927 (62%), Positives = 662/927 (71%), Gaps = 34/927 (3%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDVR 3031
            MAVEAC    L         P++FKR           SE KK   QKH  Q      DVR
Sbjct: 1    MAVEACTTTNLMEDMEDDEGPVIFKRSNPASKQNQANSEKKKLSLQKHVGQSAVHTSDVR 60

Query: 3030 SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 2851
              NG+S+  +K +  P ++TPPVK PL+SPK+SN+S KA  + SP  +SK S S T  + 
Sbjct: 61   PANGESSSAQKGRIQPSAETPPVKSPLSSPKASNSSAKASPITSPGANSKLSASATSTAK 120

Query: 2850 SVKHQIKD----EKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTST 2683
               H        E   +    + N +S+ S+D+KPL AR     SK  SNHA K    S 
Sbjct: 121  QQNHHKSSAAFIEPKPSVPPAKANSNSESSDDEKPLIARTSGCSSKGKSNHANKEGGDSC 180

Query: 2682 LSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE-- 2509
              ++  +   EDS+DE PLS +F  KS+ GES ++S +S E+KPL +K  QNGSAS +  
Sbjct: 181  SIRRPVVEESEDSEDEKPLSRRFPSKSSLGESTSKSYDSDEKKPLAAKVQQNGSASRDGP 240

Query: 2508 --RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDE------ 2353
              +  S + K+ PG+ VK+ ++S LKKPKLS   T   NK+A++K E + EDD+      
Sbjct: 241  MNKSASLSNKRAPGE-VKSLNQSSLKKPKLSSPITSISNKQAAVKPEPKAEDDDDNIPLS 299

Query: 2352 ------------------DHVPISHRMXXXXXXXXXXXXXKN-ITKPIXXXXXXXXXXXX 2230
                              D+ PIS R+                 +  +            
Sbjct: 300  QRGKKSQTAASKPKDEDDDNAPISQRIKKSPASVSKSSAPVKKASTVVSPSLKKVNKKSK 359

Query: 2229 XXXXXXXXXXXXXXXXXSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEE 2050
                             SGEGQKWTTLVHNGV+FPPPYKPHGVKMLYK +P+ LTPEQEE
Sbjct: 360  KVIKKTAYTKSSKVPPGSGEGQKWTTLVHNGVMFPPPYKPHGVKMLYKRQPLTLTPEQEE 419

Query: 2049 VATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXX 1870
            VATM+A ML+TDYMNKP+FKENF +DW+KILGKNHTIQ+LE CDF PIYEWH        
Sbjct: 420  VATMFAAMLDTDYMNKPRFKENFFSDWKKILGKNHTIQNLEDCDFGPIYEWHQQEREKKK 479

Query: 1869 XXXXXXXXXXXXXXXXXXXKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRI 1690
                               KYMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPK+GKLKKRI
Sbjct: 480  QMTTEEKKALKDERLQLEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKVGKLKKRI 539

Query: 1689 RPSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTL 1510
             P DITINIGKDAPIPECPIPGE WKE+R+DNTVTWLAYWNDP+N KE KYVFLA SSTL
Sbjct: 540  HPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAYWNDPVNLKECKYVFLAPSSTL 599

Query: 1509 KGQSDKEKYEKARLLKDYILGIRAAYTKDFTS-KDPAKRQIAVATYLIDKLALRAGNEKD 1333
            KGQSDKEKYEKARLLKDYI GIRAAYTKDFT+ KDP K+QIAVATYLIDKLALRAGNEKD
Sbjct: 600  KGQSDKEKYEKARLLKDYIHGIRAAYTKDFTNNKDPMKKQIAVATYLIDKLALRAGNEKD 659

Query: 1332 DDEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKG 1153
            DDEADTVGCCTLKVENVEPVPPN LK DF+GKDSIRYQNEV+VE AVFKAIQQFRSGK+G
Sbjct: 660  DDEADTVGCCTLKVENVEPVPPNILKIDFIGKDSIRYQNEVQVEPAVFKAIQQFRSGKEG 719

Query: 1152 GDDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQH 973
             +DLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLS+ET+GG VAEKV VYQH
Sbjct: 720  SEDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKETKGGKVAEKVGVYQH 779

Query: 972  ANKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGK 793
            ANKEVAIICNHQRTVSKSHSAQM RLNEKI+ELK  +EEL+TDL+RAKKGKPP K  DG+
Sbjct: 780  ANKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTALEELKTDLSRAKKGKPPSKGDDGE 839

Query: 792  PKRNLNPDALERKIAQTTAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHE 613
            PKRNLNP+ALERKIAQT AKIEKMERDK+TKEDLK VAL TSKI+YLDPRITVAWCKR E
Sbjct: 840  PKRNLNPEALERKIAQTNAKIEKMERDKKTKEDLKAVALSTSKISYLDPRITVAWCKRQE 899

Query: 612  VPIEKIFNKSLLAKFAWAMDVDPGFRF 532
            VPIEK+FNKSLLAKFAWAMDVDP FRF
Sbjct: 900  VPIEKMFNKSLLAKFAWAMDVDPSFRF 926


>dbj|BAG31374.1| topoisomerase I [Ophiorrhiza liukiuensis]
          Length = 926

 Score = 1096 bits (2834), Expect = 0.0
 Identities = 584/926 (63%), Positives = 661/926 (71%), Gaps = 33/926 (3%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDVR 3031
            MAVEAC    L         P++FKR           SE KK   QKH  Q      DVR
Sbjct: 1    MAVEACTTPNLMEDMEDDEGPVIFKRSNPASKQNQANSEKKKLSLQKHVGQSAVHTSDVR 60

Query: 3030 SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 2851
              NG+S+  +K +  P ++TPPVK PL+SPK+SN+S KA  + SP  +SK S S T  + 
Sbjct: 61   PANGESSSAQKGRIQPSAETPPVKSPLSSPKASNSSAKASPITSPGANSKLSASATSTAK 120

Query: 2850 SVKHQIKD----EKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTST 2683
               H        E   +    + N +S+ S+D+KPL AR     SK  SNHA K    S 
Sbjct: 121  QQNHHKSSAAFIEPKPSVPAAKANSNSESSDDEKPLIARTSGCSSKGKSNHANKEGGDSC 180

Query: 2682 LSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE-- 2509
              ++  I   EDS+DE PLS +F  KS+ GES ++S +S E+KPL +K  QNGSAS +  
Sbjct: 181  SIRRPVIEESEDSEDEKPLSRRFPSKSSLGESTSKSYDSDEKKPLATKVQQNGSASRDGP 240

Query: 2508 -RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDE------- 2353
              K ++ L KR    VK+ ++S LKK KLS   T   NK+A++K E + EDD+       
Sbjct: 241  MNKSASLLNKRAPGEVKSLNQSSLKKAKLSSPITSISNKQAAVKPEPKAEDDDDNIPLSQ 300

Query: 2352 -----------------DHVPISHRMXXXXXXXXXXXXXKN-ITKPIXXXXXXXXXXXXX 2227
                             D+ PIS R+                 +  +             
Sbjct: 301  RGKKSQTAASKPKDEDDDNAPISQRIKKSPASVSKSSAPVKKASTVVSPSLKKVNKKSKK 360

Query: 2226 XXXXXXXXXXXXXXXXSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEV 2047
                            SGEGQKWTTLVHNGV+F PPYKPHGVKMLYK +P+ LTPEQEEV
Sbjct: 361  VIKKTAYTKSSKVPPGSGEGQKWTTLVHNGVMFLPPYKPHGVKMLYKXQPLTLTPEQEEV 420

Query: 2046 ATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXX 1867
            ATM+AVML+TDYM KP+FKENF +DW+K+LGKNHT+Q+LE CDF PIYEWH         
Sbjct: 421  ATMFAVMLDTDYMTKPRFKENFFSDWKKMLGKNHTVQNLEDCDFGPIYEWHQQEKEKRKQ 480

Query: 1866 XXXXXXXXXXXXXXXXXXKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR 1687
                              KYMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR
Sbjct: 481  MTTEEKKALKEERLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR 540

Query: 1686 PSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLK 1507
            P DITINIGKDAPIPECPIPGE WKE+R+DNTVTWLA+WNDPIN KE KYVFLAASSTLK
Sbjct: 541  PRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAFWNDPINQKECKYVFLAASSTLK 600

Query: 1506 GQSDKEKYEKARLLKDYILGIRAAYTKDFTS-KDPAKRQIAVATYLIDKLALRAGNEKDD 1330
            GQSDKEKYEKARLLKDYI GIRAAYTKDFT+ KDP K+QIAVATYLIDKLALRAGNEKDD
Sbjct: 601  GQSDKEKYEKARLLKDYIHGIRAAYTKDFTNNKDPMKKQIAVATYLIDKLALRAGNEKDD 660

Query: 1329 DEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGG 1150
            DEADTVGCCTLKVENVEPVPPN LK DF+GKDSIRYQNEV+VE AVFKAIQQFRSGK+G 
Sbjct: 661  DEADTVGCCTLKVENVEPVPPNILKIDFIGKDSIRYQNEVQVEPAVFKAIQQFRSGKEGC 720

Query: 1149 DDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHA 970
             DLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLS+ET+GG VAEKV VYQHA
Sbjct: 721  ADLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKETKGGKVAEKVGVYQHA 780

Query: 969  NKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGKP 790
            NKEVAIICNHQRTVSKSHSAQM RLNEKI+ELK  +EEL+TDL+RAKKGKPP K ADG+P
Sbjct: 781  NKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTALEELKTDLSRAKKGKPPAKGADGEP 840

Query: 789  KRNLNPDALERKIAQTTAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHEV 610
            KRNLNP++LERKIAQT AKIEKMERDK+TKEDLK VAL TSKI+YLDPRITVAWCKRHEV
Sbjct: 841  KRNLNPESLERKIAQTNAKIEKMERDKKTKEDLKAVALSTSKISYLDPRITVAWCKRHEV 900

Query: 609  PIEKIFNKSLLAKFAWAMDVDPGFRF 532
            PIEKIFNKSLLAKFAW+MDVDP FRF
Sbjct: 901  PIEKIFNKSLLAKFAWSMDVDPSFRF 926


>ref|XP_009619726.1| PREDICTED: LOW QUALITY PROTEIN: DNA topoisomerase 1-like [Nicotiana
            tomentosiformis]
          Length = 877

 Score = 1095 bits (2832), Expect = 0.0
 Identities = 587/899 (65%), Positives = 653/899 (72%), Gaps = 6/899 (0%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXE--PLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPD 3037
            MAVEA  K KL        +  PLVFKR                S SQK D + GR A D
Sbjct: 1    MAVEAFSKTKLMAEVDDDDDDMPLVFKRSSTTSKQ-----NQSNSSSQKQDGRSGRQASD 55

Query: 3036 VRSQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDK 2857
            VRS NGQS+  +K K    SK      P TSPK+S +SG+     SP  +S+PS S  ++
Sbjct: 56   VRSPNGQSSSAQKVKAGTSSKASRAVSPFTSPKASPSSGRT----SPAPNSRPSASAGNQ 111

Query: 2856 SNSVKHQIK----DEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNT 2689
            +  V  Q K    + K + E   EPN++++DSEDDKPLSARL +GLSK NS+HA K   T
Sbjct: 112  AKDVNQQSKIVPNEPKQAVEPKSEPNDEAEDSEDDKPLSARLSSGLSKSNSSHANKVLGT 171

Query: 2688 STLSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE 2509
            S   QK R P  EDSDDEIPL+S+FQ+KSNAG S ++SSNS E KP   K  QNG  ST 
Sbjct: 172  SASVQKSRPPKKEDSDDEIPLASRFQLKSNAGASTSKSSNSEEVKP---KIRQNGLPST- 227

Query: 2508 RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDEDHVPISHR 2329
                T L KRP   V       LK           +   AS+K E + EDD+D VPIS R
Sbjct: 228  ----TVLSKRPPGDVSLLLRLQLKSLGFLMHLHLFRVSXASVKPEKKTEDDDDDVPISQR 283

Query: 2328 MXXXXXXXXXXXXXKNITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSGEGQKWTTL 2149
            +             K  TK +                              GEGQKWTTL
Sbjct: 284  IKKSVASASKLSSAKKATKVVSSSMKTKKKLKKSKYSKSSKLQPSS-----GEGQKWTTL 338

Query: 2148 VHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKPKFKENFMADW 1969
            VHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVML+TDYM+K +FKENFM DW
Sbjct: 339  VHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLDTDYMSKLQFKENFMNDW 398

Query: 1968 RKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXXXXKYMWAIVN 1789
            RKILGKNH IQ+L+ CDFTPIYEWH                           KYMWAIV+
Sbjct: 399  RKILGKNHVIQNLDDCDFTPIYEWHQSEKEKKKQMSTEEKKALREEKLKQEEKYMWAIVD 458

Query: 1788 GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWKE 1609
            GVKEKVGNFRVEPPGLFRGRGEHPKMGKLK+RIRP+DITINIGK APIPECPIPGE WKE
Sbjct: 459  GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPNDITINIGKGAPIPECPIPGERWKE 518

Query: 1608 IRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYILGIRAAYT 1429
            +RHDNTVTWLA+WNDPINP+EFKYVFLAASS+LKGQSDKEKYEKAR LKDYI GIR+AYT
Sbjct: 519  VRHDNTVTWLAFWNDPINPREFKYVFLAASSSLKGQSDKEKYEKARRLKDYIEGIRSAYT 578

Query: 1428 KDFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNTLKFD 1249
            KDFTSKDP KRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPN LKFD
Sbjct: 579  KDFTSKDPVKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNILKFD 638

Query: 1248 FLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLKELMPGLTAKV 1069
            FLGKDSIRYQNEV V   VFKAIQ FRSGKKGGDDLFD+LDTSKLNAHLKELMPGLTAKV
Sbjct: 639  FLGKDSIRYQNEVAVYEPVFKAIQLFRSGKKGGDDLFDKLDTSKLNAHLKELMPGLTAKV 698

Query: 1068 FRTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMLRLNE 889
            FRTYNAS+TL+  L++ T+GG++AEKV VY  ANKEVAIICNHQR+VSKSHS Q+ +LNE
Sbjct: 699  FRTYNASVTLEQQLTKLTQGGELAEKVAVYNLANKEVAIICNHQRSVSKSHSVQISKLNE 758

Query: 888  KIEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNLNPDALERKIAQTTAKIEKMERDK 709
            KI+ELK ++EE + DLARAKKGKPPLK ADGK KRNL P+AL++KI QT  KIE +ER  
Sbjct: 759  KIDELKALLEEFKVDLARAKKGKPPLKGADGKAKRNLAPEALQKKIDQTNVKIENIERQI 818

Query: 708  ETKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPGFRF 532
            ETKE+LKTVALGTSKINYLDPRITVAWCKRHEVPIEK+FNKSLLAKFAWAMDV+P F F
Sbjct: 819  ETKEELKTVALGTSKINYLDPRITVAWCKRHEVPIEKMFNKSLLAKFAWAMDVEPSFTF 877


>ref|XP_009790344.1| PREDICTED: LOW QUALITY PROTEIN: DNA topoisomerase 1-like [Nicotiana
            sylvestris]
          Length = 876

 Score = 1082 bits (2799), Expect = 0.0
 Identities = 578/899 (64%), Positives = 652/899 (72%), Gaps = 6/899 (0%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXE--PLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPD 3037
            MAVEA  K KL        +  PLVFKR                S SQK D + GR   D
Sbjct: 1    MAVEAFSKTKLMAEVDDDDDDMPLVFKRSTTSKQ------NQSNSSSQKQDGRSGRQVSD 54

Query: 3036 VRSQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDK 2857
            VRS NGQ++  +K K    SK  P   P TSPK+S +S +     SP  +S+PS S  ++
Sbjct: 55   VRSPNGQNSSAQKVKAGTSSKASPAVSPFTSPKASPSSSRI----SPAPNSRPSASAGNQ 110

Query: 2856 SNSVKHQIK----DEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNT 2689
            + +V  Q K    + K + E    PN++++DSEDDKPLSARL +GLSK  S+HA K   T
Sbjct: 111  AKNVNQQSKIVPNEPKQAVEPKSGPNDEAEDSEDDKPLSARLSSGLSKSISSHANKVLGT 170

Query: 2688 STLSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE 2509
            S   QK + P  EDSDDEIPL+S+FQ+KSNAG S ++SSNS E KP   K  QNG  ST 
Sbjct: 171  SASVQKSKPPKKEDSDDEIPLASRFQLKSNAGASTSKSSNSEEVKP---KIRQNGLPST- 226

Query: 2508 RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDEDHVPISHR 2329
                T L KRP   V       LK           +   AS+K E + EDD+D VPIS R
Sbjct: 227  ----TVLSKRPPGDVSLLLRLQLKSLGFLMHLHLFRLSXASVKPEKKTEDDDDDVPISQR 282

Query: 2328 MXXXXXXXXXXXXXKNITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXSGEGQKWTTL 2149
            +             K  TK +                              GEGQKWTTL
Sbjct: 283  IKKSVASASKVSSTKKATKVVSSSMKTKKKLKKSKYSKSSKLQPSS-----GEGQKWTTL 337

Query: 2148 VHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKPKFKENFMADW 1969
            VHNGVIFPP YKPHGVKMLYKGKP++LTPEQEEVATMYAVML+T+YM+KP+FKENFM DW
Sbjct: 338  VHNGVIFPPSYKPHGVKMLYKGKPINLTPEQEEVATMYAVMLDTEYMSKPQFKENFMNDW 397

Query: 1968 RKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXXXXKYMWAIVN 1789
            RKILGKNH IQ+L+ CDFTPIYEWH                           KYMWAIV+
Sbjct: 398  RKILGKNHVIQNLDDCDFTPIYEWHQSEKEKKKQMSTEEKKALREEKLKQEEKYMWAIVD 457

Query: 1788 GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWKE 1609
            GVKEKVGNFRVEPPGLFRGRGEHPKMGKLK+RIRP+DITINIGK APIPECPIPGE WKE
Sbjct: 458  GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPNDITINIGKGAPIPECPIPGERWKE 517

Query: 1608 IRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYILGIRAAYT 1429
            +RHDNTVTWLA+WNDPINP+EFKYVFLAASS+LKGQSDKEKYEKAR LKDYI GIR+AYT
Sbjct: 518  VRHDNTVTWLAFWNDPINPREFKYVFLAASSSLKGQSDKEKYEKARRLKDYIEGIRSAYT 577

Query: 1428 KDFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNTLKFD 1249
            KDFTSKDP KRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPN LKFD
Sbjct: 578  KDFTSKDPVKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNILKFD 637

Query: 1248 FLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLKELMPGLTAKV 1069
            FLGKDSIRYQNEV V   VFKAIQ FRSGKKGGDDLFD+LDTSKLNAHLKELMPGLTAKV
Sbjct: 638  FLGKDSIRYQNEVAVYEPVFKAIQLFRSGKKGGDDLFDKLDTSKLNAHLKELMPGLTAKV 697

Query: 1068 FRTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMLRLNE 889
            FRTYNAS+TL+  L++ T+GG++AEKV VY  ANKEVAIICNHQR+VSKSHS Q+ +LNE
Sbjct: 698  FRTYNASVTLEQQLTKLTQGGELAEKVAVYNLANKEVAIICNHQRSVSKSHSVQISKLNE 757

Query: 888  KIEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNLNPDALERKIAQTTAKIEKMERDK 709
            KI+ELK ++EE + DLARAKKGKPPLK ADGK KRNL P+AL++K+ QT AKIE +E+  
Sbjct: 758  KIDELKALLEEFKVDLARAKKGKPPLKGADGKAKRNLAPEALQKKMDQTNAKIENIEKQI 817

Query: 708  ETKEDLKTVALGTSKINYLDPRITVAWCKRHEVPIEKIFNKSLLAKFAWAMDVDPGFRF 532
            ETKE+LKTVALGTSKINYLDPRITVAWCKRHEVPIEK+FNKSLLAKFAWAMDV+P F F
Sbjct: 818  ETKEELKTVALGTSKINYLDPRITVAWCKRHEVPIEKMFNKSLLAKFAWAMDVEPSFTF 876


>dbj|BAK32959.1| topoisomerase I [Ophiorrhiza plumbea]
          Length = 920

 Score = 1082 bits (2799), Expect = 0.0
 Identities = 578/920 (62%), Positives = 655/920 (71%), Gaps = 34/920 (3%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDVR 3031
            MAVEAC    L         P++FKR           SE KK   QKH  Q      DVR
Sbjct: 1    MAVEACTTPNLMEDMEDDEGPVIFKRSNPASKQNQANSEKKKLSLQKHVGQSAVHTSDVR 60

Query: 3030 SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 2851
              NG+S+  +K +  P ++TPPVK PL+SPK+SN+S KA  + SP  +SK S S T  + 
Sbjct: 61   PANGESSSAQKGRIQPSAETPPVKSPLSSPKASNSSAKASPITSPGANSKLSASATSTAK 120

Query: 2850 SVKHQIKD----EKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTST 2683
               H        E   +    + N +S+ S+D+KPL AR     SK  SNHA K    S 
Sbjct: 121  QQNHHKSSAAFIEPKPSVPAAKANSNSESSDDEKPLIARTSGCSSKGKSNHANKEGGDSC 180

Query: 2682 LSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE-- 2509
              ++  I   EDS+DE PLS +F  KS+ GES ++S +S E+KPL +K   NGSAS +  
Sbjct: 181  SIRRPVIEESEDSEDEKPLSRRFPSKSSLGESTSKSYDSDEKKPLAAKVQPNGSASRDGP 240

Query: 2508 --RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDE------ 2353
              +  S + K+ PG+ VK+ ++S LKKPKLS   T   NK+A++K E + EDD+      
Sbjct: 241  MNKSASLSNKRAPGE-VKSLNQSSLKKPKLSSPITSISNKQAAVKPEPKAEDDDDNIPLS 299

Query: 2352 ------------------DHVPISHRMXXXXXXXXXXXXXKN-ITKPIXXXXXXXXXXXX 2230
                              D+ PIS R+                 +  +            
Sbjct: 300  QRGKKSQTAASKPKDEDDDNAPISQRIKKSPASVSKSSAPVKKASTVVSPSLKKVNKKSK 359

Query: 2229 XXXXXXXXXXXXXXXXXSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEE 2050
                             SGEGQKWTTLVHNGVIFPPPYKPHGVKMLYK +P+ LTPEQEE
Sbjct: 360  KVIKKTAYTKSSKVPPGSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKRQPITLTPEQEE 419

Query: 2049 VATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXX 1870
            VATM+AVML+TDYMNKP+FKENF +DW+K+LGKNHTIQ+LE CDF PIYEWH        
Sbjct: 420  VATMFAVMLDTDYMNKPRFKENFFSDWKKMLGKNHTIQNLEDCDFGPIYEWHQQEKEKKK 479

Query: 1869 XXXXXXXXXXXXXXXXXXXKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRI 1690
                               KYMW IV+GVKEKVGNFRVEPPGLFRGRGEHPK+GKLKKRI
Sbjct: 480  QMTTEEKKALKEERLQQEEKYMWVIVDGVKEKVGNFRVEPPGLFRGRGEHPKVGKLKKRI 539

Query: 1689 RPSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTL 1510
            RP DITINIGKDAPIPECPIPGE WKE+R+DNTVTWLAYWNDPIN KE KYVFL ASSTL
Sbjct: 540  RPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAYWNDPINQKERKYVFLGASSTL 599

Query: 1509 KGQSDKEKYEKARLLKDYILGIRAAYTKDFTS-KDPAKRQIAVATYLIDKLALRAGNEKD 1333
            KGQSDKEKYEKARLLKDYI GIRAAYTKDFT+ KDP K+QIAVATYLIDKLALRAGNEKD
Sbjct: 600  KGQSDKEKYEKARLLKDYIHGIRAAYTKDFTNNKDPMKKQIAVATYLIDKLALRAGNEKD 659

Query: 1332 DDEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKG 1153
            DDEADTVGCCTLKVENVEPVPPN LK DF+GKDSIRYQNEV+VE AVFKAIQQFRSGK+G
Sbjct: 660  DDEADTVGCCTLKVENVEPVPPNILKIDFIGKDSIRYQNEVQVEPAVFKAIQQFRSGKEG 719

Query: 1152 GDDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQH 973
              DLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLS+ET+GG VAEKV VYQH
Sbjct: 720  SADLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKETKGGKVAEKVGVYQH 779

Query: 972  ANKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGK 793
            ANKEVAIICNHQRTVSKSHSAQM RLNEKI+ELK  +EEL+TDL+RAKKGKPP K ADG+
Sbjct: 780  ANKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTALEELKTDLSRAKKGKPPSKGADGE 839

Query: 792  PKRNLNPDALERKIAQTTAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHE 613
            PKRNLNP+ALERKIAQT AKIEKME DK+TKEDLK VAL TSKI+YL PRITVAWCKRHE
Sbjct: 840  PKRNLNPEALERKIAQTNAKIEKMEGDKKTKEDLKAVALSTSKISYLGPRITVAWCKRHE 899

Query: 612  VPIEKIFNKSLLAKFAWAMD 553
            VPIEK+FNKSLLAKFAWAM+
Sbjct: 900  VPIEKMFNKSLLAKFAWAMN 919


>dbj|BAK32963.1| topoisomerase I [Ophiorrhiza sp. 35]
          Length = 920

 Score = 1082 bits (2798), Expect = 0.0
 Identities = 576/920 (62%), Positives = 657/920 (71%), Gaps = 34/920 (3%)
 Frame = -3

Query: 3210 MAVEACDKQKLXXXXXXXXEPLVFKRXXXXXXXXXXXSEAKKSLSQKHDRQLGRPAPDVR 3031
            MAVEAC    L         P++FKR           SE KK   QKH  Q      DVR
Sbjct: 1    MAVEACTTTNLMEDMEDDEGPVIFKRSNPASKQNQANSEKKKLSLQKHVGQSAVHTSDVR 60

Query: 3030 SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 2851
              NG+S+  +K +  P ++TPPVK PL+SPK+SN+S KA  + SP  +SK S S T  + 
Sbjct: 61   PANGESSSAQKGRIQPSAETPPVKSPLSSPKASNSSAKASPITSPGANSKLSASATSTAK 120

Query: 2850 SVKHQIKD----EKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTST 2683
               H        E   +    + N +S+ S+D+KPL AR     SK  SNHA K    S 
Sbjct: 121  QQNHHKSSAAFIEPKPSVPPAKANSNSESSDDEKPLIARTSGCSSKGKSNHANKEGGDSC 180

Query: 2682 LSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE-- 2509
              ++  +   EDS+DE PLS +F  KS+ GES ++S +S E+KPL +K  QNGSAS +  
Sbjct: 181  SIRRPVVEESEDSEDEKPLSRRFPSKSSLGESTSKSYDSDEKKPLAAKVQQNGSASRDGP 240

Query: 2508 --RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDE------ 2353
              +  S + K+ PG+ VK+ ++S LKKPKLS   T   NK+A++K E + EDD+      
Sbjct: 241  MNKSASLSNKRAPGE-VKSLNQSSLKKPKLSSPITSISNKQAAVKPEPKAEDDDDNIPLS 299

Query: 2352 ------------------DHVPISHRMXXXXXXXXXXXXXKN-ITKPIXXXXXXXXXXXX 2230
                              D+ PIS R+                 +  +            
Sbjct: 300  QRGKKSQTAASKPKDEDDDNAPISQRIKKSPASVSKSSAPVKKASTVVSPSLKKVNKKSK 359

Query: 2229 XXXXXXXXXXXXXXXXXSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEE 2050
                             SGEGQKWTTLVHNGVIFPPPYKPHGVKMLYK +P+ LTPEQEE
Sbjct: 360  KVIKKTAYTKSSKVPPGSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKRQPLTLTPEQEE 419

Query: 2049 VATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXX 1870
            VATM+AVML+TDYMNKP+FKENF +DW+K+LGKNHTIQ+LE CDF PIYEWH        
Sbjct: 420  VATMFAVMLDTDYMNKPRFKENFFSDWKKMLGKNHTIQNLEDCDFGPIYEWHQQEREKKK 479

Query: 1869 XXXXXXXXXXXXXXXXXXXKYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRI 1690
                               KYMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPK+GKLKKRI
Sbjct: 480  QMTTEEKKALKDERLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKVGKLKKRI 539

Query: 1689 RPSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTL 1510
             P DITINIGKDAPIPECPIPGE WKE+R+DNTVTWLAYWNDP+N KE KYVFLA SSTL
Sbjct: 540  HPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAYWNDPVNLKECKYVFLAPSSTL 599

Query: 1509 KGQSDKEKYEKARLLKDYILGIRAAYTKDFTS-KDPAKRQIAVATYLIDKLALRAGNEKD 1333
            KGQSDKEKYEKARLLKDYI GIRAAYTKDFT+ KDP K+QIAVATYLIDKLALRAGNEKD
Sbjct: 600  KGQSDKEKYEKARLLKDYIHGIRAAYTKDFTNNKDPMKKQIAVATYLIDKLALRAGNEKD 659

Query: 1332 DDEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKG 1153
            DDEADTVGCCTL+VENVEPVPPN LK DF+GKDSIRYQNEV+VE AVFKAIQQFRSGK+G
Sbjct: 660  DDEADTVGCCTLRVENVEPVPPNILKIDFIGKDSIRYQNEVQVEPAVFKAIQQFRSGKEG 719

Query: 1152 GDDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQH 973
             +DLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLS+ET+GG VAEKV VYQH
Sbjct: 720  SEDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKETKGGKVAEKVGVYQH 779

Query: 972  ANKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGK 793
            ANKEVAIICNHQRTVSKSHSAQM RLNEKI+ELK  +EEL+TDL+RAKKGKPP K  DG+
Sbjct: 780  ANKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTALEELKTDLSRAKKGKPPSKGDDGE 839

Query: 792  PKRNLNPDALERKIAQTTAKIEKMERDKETKEDLKTVALGTSKINYLDPRITVAWCKRHE 613
            PKRNLNP+ALERKIAQT AKIEKMERDK+TKEDLK VAL TSKI+YLDPRITVAWCKR E
Sbjct: 840  PKRNLNPEALERKIAQTNAKIEKMERDKKTKEDLKAVALSTSKISYLDPRITVAWCKRQE 899

Query: 612  VPIEKIFNKSLLAKFAWAMD 553
            VPIEK+FNKSLLAKFAWAM+
Sbjct: 900  VPIEKMFNKSLLAKFAWAMN 919