BLASTX 2.2.25 [Feb-01-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Rehmannia25_contig00017749
         (379 letters)

Database: ./nr 
           37,332,560 sequences; 13,225,080,153 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

ref|XP_006429101.1| hypothetical protein CICLE_v10011927mg [Citr...   172   3e-41
ref|XP_006429099.1| hypothetical protein CICLE_v10011927mg [Citr...   172   3e-41
ref|XP_006429098.1| hypothetical protein CICLE_v10011927mg [Citr...   172   3e-41
gb|EOY07506.1| RHOMBOID-like 1 [Theobroma cacao]                      172   4e-41
ref|XP_006429100.1| hypothetical protein CICLE_v10011927mg [Citr...   168   6e-40
gb|EPS62694.1| hypothetical protein M569_12091, partial [Genlise...   168   6e-40
emb|CBI30545.3| unnamed protein product [Vitis vinifera]              168   8e-40
ref|XP_002270642.1| PREDICTED: inactive rhomboid protein 1 [Viti...   168   8e-40
emb|CAN71797.1| hypothetical protein VITISV_026278 [Vitis vinifera]   168   8e-40
ref|XP_006341018.1| PREDICTED: inactive rhomboid protein 1-like ...   166   2e-39
ref|XP_002533096.1| KOM, putative [Ricinus communis] gi|22352710...   166   3e-39
gb|EXC30978.1| Inactive rhomboid protein 1 [Morus notabilis]          165   7e-39
ref|XP_004246443.1| PREDICTED: inactive rhomboid protein 1-like ...   165   7e-39
gb|ESW05983.1| hypothetical protein PHAVU_010G009600g [Phaseolus...   160   1e-37
ref|XP_004516493.1| PREDICTED: inactive rhomboid protein 1-like ...   160   1e-37
ref|XP_003520922.1| PREDICTED: inactive rhomboid protein 1-like ...   160   2e-37
ref|XP_006601825.1| PREDICTED: uncharacterized protein LOC100805...   160   2e-37
ref|NP_001242137.1| uncharacterized protein LOC100805186 [Glycin...   160   2e-37
gb|EMJ06522.1| hypothetical protein PRUPE_ppa006931mg [Prunus pe...   159   5e-37
ref|XP_004156648.1| PREDICTED: uncharacterized protein LOC101224...   158   8e-37

>ref|XP_006429101.1| hypothetical protein CICLE_v10011927mg [Citrus clementina]
           gi|557531158|gb|ESR42341.1| hypothetical protein
           CICLE_v10011927mg [Citrus clementina]
          Length = 309

 Score =  172 bits (437), Expect = 3e-41
 Identities = 84/110 (76%), Positives = 93/110 (84%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           L+KMGALDV KVVD+H+GWRLITC WLHGGVFH+LANMLSL+VIGIRLEQEFGF+R+GLL
Sbjct: 115 LQKMGALDVSKVVDKHQGWRLITCNWLHGGVFHILANMLSLLVIGIRLEQEFGFIRVGLL 174

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           Y+ISGFGGSLLSALFIQSNISV              SELITNWTIY NK+
Sbjct: 175 YIISGFGGSLLSALFIQSNISVGASGALFGLLGSMLSELITNWTIYTNKI 224


>ref|XP_006429099.1| hypothetical protein CICLE_v10011927mg [Citrus clementina]
           gi|568854444|ref|XP_006480836.1| PREDICTED: inactive
           rhomboid protein 1-like isoform X1 [Citrus sinensis]
           gi|557531156|gb|ESR42339.1| hypothetical protein
           CICLE_v10011927mg [Citrus clementina]
          Length = 391

 Score =  172 bits (437), Expect = 3e-41
 Identities = 84/110 (76%), Positives = 93/110 (84%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           L+KMGALDV KVVD+H+GWRLITC WLHGGVFH+LANMLSL+VIGIRLEQEFGF+R+GLL
Sbjct: 115 LQKMGALDVSKVVDKHQGWRLITCNWLHGGVFHILANMLSLLVIGIRLEQEFGFIRVGLL 174

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           Y+ISGFGGSLLSALFIQSNISV              SELITNWTIY NK+
Sbjct: 175 YIISGFGGSLLSALFIQSNISVGASGALFGLLGSMLSELITNWTIYTNKI 224


>ref|XP_006429098.1| hypothetical protein CICLE_v10011927mg [Citrus clementina]
           gi|557531155|gb|ESR42338.1| hypothetical protein
           CICLE_v10011927mg [Citrus clementina]
          Length = 313

 Score =  172 bits (437), Expect = 3e-41
 Identities = 84/110 (76%), Positives = 93/110 (84%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           L+KMGALDV KVVD+H+GWRLITC WLHGGVFH+LANMLSL+VIGIRLEQEFGF+R+GLL
Sbjct: 115 LQKMGALDVSKVVDKHQGWRLITCNWLHGGVFHILANMLSLLVIGIRLEQEFGFIRVGLL 174

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           Y+ISGFGGSLLSALFIQSNISV              SELITNWTIY NK+
Sbjct: 175 YIISGFGGSLLSALFIQSNISVGASGALFGLLGSMLSELITNWTIYTNKI 224


>gb|EOY07506.1| RHOMBOID-like 1 [Theobroma cacao]
          Length = 383

 Score =  172 bits (436), Expect = 4e-41
 Identities = 87/110 (79%), Positives = 93/110 (84%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           L+KMGALDV KVVD H+GWRLITC WLHGGVFHLLANMLSL+VIGIRLE+EFGF+RIGLL
Sbjct: 107 LQKMGALDVKKVVDGHQGWRLITCNWLHGGVFHLLANMLSLLVIGIRLEREFGFIRIGLL 166

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           Y+ISGFGGSLLSALFIQSNISV              SELITNWTIYANKV
Sbjct: 167 YIISGFGGSLLSALFIQSNISVGASGALFGLLGAMLSELITNWTIYANKV 216


>ref|XP_006429100.1| hypothetical protein CICLE_v10011927mg [Citrus clementina]
           gi|568854446|ref|XP_006480837.1| PREDICTED: inactive
           rhomboid protein 1-like isoform X2 [Citrus sinensis]
           gi|557531157|gb|ESR42340.1| hypothetical protein
           CICLE_v10011927mg [Citrus clementina]
          Length = 274

 Score =  168 bits (426), Expect = 6e-40
 Identities = 82/107 (76%), Positives = 90/107 (84%)
 Frame = -3

Query: 365 MGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLLYLI 186
           MGALDV KVVD+H+GWRLITC WLHGGVFH+LANMLSL+VIGIRLEQEFGF+R+GLLY+I
Sbjct: 1   MGALDVSKVVDKHQGWRLITCNWLHGGVFHILANMLSLLVIGIRLEQEFGFIRVGLLYII 60

Query: 185 SGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           SGFGGSLLSALFIQSNISV              SELITNWTIY NK+
Sbjct: 61  SGFGGSLLSALFIQSNISVGASGALFGLLGSMLSELITNWTIYTNKI 107


>gb|EPS62694.1| hypothetical protein M569_12091, partial [Genlisea aurea]
          Length = 380

 Score =  168 bits (426), Expect = 6e-40
 Identities = 85/110 (77%), Positives = 92/110 (83%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           LEKMGALDV KVV +H+ WRLITCMWLH GVFHLLANMLSLIVIGIRLEQEFGFVRIGLL
Sbjct: 104 LEKMGALDVSKVVHQHQWWRLITCMWLHAGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 163

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           Y+ISGFGGSLLS+LFIQS++SV              SEL+TNWTIYANKV
Sbjct: 164 YIISGFGGSLLSSLFIQSDLSVGASGALFGLLGGMLSELLTNWTIYANKV 213


>emb|CBI30545.3| unnamed protein product [Vitis vinifera]
          Length = 320

 Score =  168 bits (425), Expect = 8e-40
 Identities = 82/110 (74%), Positives = 92/110 (83%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           L+KMGALDV +VVD H+GWRLITC+WLHGGVFHLLANMLSL+VIGIRLEQEFGFV++GLL
Sbjct: 44  LQKMGALDVSRVVDRHQGWRLITCIWLHGGVFHLLANMLSLLVIGIRLEQEFGFVKVGLL 103

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           Y+ISGFGGSLLS LFIQ NISV              SELITNW+IYANK+
Sbjct: 104 YVISGFGGSLLSGLFIQENISVGASGALFGLLGGMLSELITNWSIYANKL 153


>ref|XP_002270642.1| PREDICTED: inactive rhomboid protein 1 [Vitis vinifera]
          Length = 388

 Score =  168 bits (425), Expect = 8e-40
 Identities = 82/110 (74%), Positives = 92/110 (83%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           L+KMGALDV +VVD H+GWRLITC+WLHGGVFHLLANMLSL+VIGIRLEQEFGFV++GLL
Sbjct: 112 LQKMGALDVSRVVDRHQGWRLITCIWLHGGVFHLLANMLSLLVIGIRLEQEFGFVKVGLL 171

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           Y+ISGFGGSLLS LFIQ NISV              SELITNW+IYANK+
Sbjct: 172 YVISGFGGSLLSGLFIQENISVGASGALFGLLGGMLSELITNWSIYANKL 221


>emb|CAN71797.1| hypothetical protein VITISV_026278 [Vitis vinifera]
          Length = 754

 Score =  168 bits (425), Expect = 8e-40
 Identities = 82/110 (74%), Positives = 92/110 (83%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           L+KMGALDV +VVD H+GWRLITC+WLHGGVFHLLANMLSL+VIGIRLEQEFGFV++GLL
Sbjct: 112 LQKMGALDVSRVVDRHQGWRLITCIWLHGGVFHLLANMLSLLVIGIRLEQEFGFVKVGLL 171

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           Y+ISGFGGSLLS LFIQ NISV              SELITNW+IYANK+
Sbjct: 172 YVISGFGGSLLSGLFIQENISVGASGALFGLLGGMLSELITNWSIYANKL 221


>ref|XP_006341018.1| PREDICTED: inactive rhomboid protein 1-like [Solanum tuberosum]
          Length = 386

 Score =  166 bits (421), Expect = 2e-39
 Identities = 83/110 (75%), Positives = 91/110 (82%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           LEKMGALDV KVV EH+GWRLITCMWLHGGVFHLLANMLSL+VIGIRLE+EFGFVRIG+L
Sbjct: 110 LEKMGALDVNKVVREHQGWRLITCMWLHGGVFHLLANMLSLLVIGIRLEREFGFVRIGVL 169

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           Y+I+G GGSL SALFI+SNISV              SELI NWTIYANK+
Sbjct: 170 YIIAGLGGSLFSALFIKSNISVGASGALFGLLGSMLSELIINWTIYANKI 219


>ref|XP_002533096.1| KOM, putative [Ricinus communis] gi|223527108|gb|EEF29288.1| KOM,
           putative [Ricinus communis]
          Length = 408

 Score =  166 bits (420), Expect = 3e-39
 Identities = 82/110 (74%), Positives = 91/110 (82%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           LEKMGALDV KVVD H+ WRL++CMWLH GVFH+LANMLSL+ IGIRLEQEFGF+RIGL+
Sbjct: 129 LEKMGALDVDKVVDGHQAWRLLSCMWLHAGVFHILANMLSLVFIGIRLEQEFGFIRIGLV 188

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           Y+ISGFGGSLLSALFIQSNISV              SELITNWTIYANK+
Sbjct: 189 YVISGFGGSLLSALFIQSNISVGASGALFGLLGGMLSELITNWTIYANKL 238


>gb|EXC30978.1| Inactive rhomboid protein 1 [Morus notabilis]
          Length = 390

 Score =  165 bits (417), Expect = 7e-39
 Identities = 81/110 (73%), Positives = 93/110 (84%)
 Frame = -3

Query: 377 ALEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGL 198
           +L+KMGALDV KVV++H+GWRL++C WLHGGVFH+LANMLSL+VIGIRLEQEFGFVRIGL
Sbjct: 112 SLQKMGALDVSKVVNDHQGWRLLSCNWLHGGVFHILANMLSLLVIGIRLEQEFGFVRIGL 171

Query: 197 LYLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANK 48
           LY+ISGFGGSLLSALF+QSNISV              SELITNWTIY +K
Sbjct: 172 LYVISGFGGSLLSALFLQSNISVGASGALFGLLGGMLSELITNWTIYDSK 221


>ref|XP_004246443.1| PREDICTED: inactive rhomboid protein 1-like [Solanum lycopersicum]
          Length = 383

 Score =  165 bits (417), Expect = 7e-39
 Identities = 82/110 (74%), Positives = 90/110 (81%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           LEKMGALDV KVV EH+GWRL TCMWLHGGVFHLLANMLSL+VIGIRLE+EFGFVRIG+L
Sbjct: 107 LEKMGALDVNKVVREHQGWRLFTCMWLHGGVFHLLANMLSLLVIGIRLEREFGFVRIGVL 166

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           Y+I+G GGSL SALFI+SNISV              SELI NWTIYANK+
Sbjct: 167 YIIAGLGGSLFSALFIKSNISVGASGALFGLLGSMLSELIINWTIYANKI 216


>gb|ESW05983.1| hypothetical protein PHAVU_010G009600g [Phaseolus vulgaris]
          Length = 383

 Score =  160 bits (406), Expect = 1e-37
 Identities = 80/110 (72%), Positives = 89/110 (80%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           L+KMGALDV +VV  H+GWRLI+CMWLH GVFHLLANML ++VIGIRLEQEFGFV IGLL
Sbjct: 106 LQKMGALDVSRVVHRHQGWRLISCMWLHAGVFHLLANMLGILVIGIRLEQEFGFVLIGLL 165

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           ++ISGFGGSLLSALFIQSNISV              SELITNWTIY NK+
Sbjct: 166 FVISGFGGSLLSALFIQSNISVGASGALFGLLGGMLSELITNWTIYENKL 215


>ref|XP_004516493.1| PREDICTED: inactive rhomboid protein 1-like [Cicer arietinum]
          Length = 380

 Score =  160 bits (406), Expect = 1e-37
 Identities = 80/109 (73%), Positives = 88/109 (80%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           L+KMGALDV +VV  H+GWRLITCMWLHGGVFHLLANML ++ IGIRLEQEFGFV IGLL
Sbjct: 103 LQKMGALDVNRVVHRHQGWRLITCMWLHGGVFHLLANMLGILFIGIRLEQEFGFVLIGLL 162

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANK 48
           Y+ISGFGGSLLSALFIQSNISV              SELITNW++Y NK
Sbjct: 163 YVISGFGGSLLSALFIQSNISVGASGALFGLLGGMLSELITNWSMYDNK 211


>ref|XP_003520922.1| PREDICTED: inactive rhomboid protein 1-like [Glycine max]
          Length = 385

 Score =  160 bits (405), Expect = 2e-37
 Identities = 80/110 (72%), Positives = 89/110 (80%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           L+KMGALDV +VV  H+GWRLITCMWLH GVFHLLANML ++VIGIRLEQEFGFV IGLL
Sbjct: 108 LQKMGALDVSRVVHRHQGWRLITCMWLHAGVFHLLANMLGILVIGIRLEQEFGFVLIGLL 167

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           ++ISGFGGSLLSALFIQSNISV              SELITNW+IY NK+
Sbjct: 168 FVISGFGGSLLSALFIQSNISVGASGALFGLLGGMLSELITNWSIYDNKL 217


>ref|XP_006601825.1| PREDICTED: uncharacterized protein LOC100805186 isoform X1 [Glycine
           max]
          Length = 293

 Score =  160 bits (404), Expect = 2e-37
 Identities = 79/110 (71%), Positives = 89/110 (80%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           L+KMGALDV +VV +H+GWRL+TCMWLH GVFHLLANML ++VIGIRLEQEFGFV IGLL
Sbjct: 16  LQKMGALDVSRVVHKHQGWRLVTCMWLHAGVFHLLANMLGILVIGIRLEQEFGFVLIGLL 75

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           + ISGFGGSLLSALFIQSNISV              SELITNW+IY NK+
Sbjct: 76  FFISGFGGSLLSALFIQSNISVGASGALFGLLGGMLSELITNWSIYDNKL 125


>ref|NP_001242137.1| uncharacterized protein LOC100805186 [Glycine max]
           gi|255644920|gb|ACU22960.1| unknown [Glycine max]
          Length = 384

 Score =  160 bits (404), Expect = 2e-37
 Identities = 79/110 (71%), Positives = 89/110 (80%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           L+KMGALDV +VV +H+GWRL+TCMWLH GVFHLLANML ++VIGIRLEQEFGFV IGLL
Sbjct: 107 LQKMGALDVSRVVHKHQGWRLVTCMWLHAGVFHLLANMLGILVIGIRLEQEFGFVLIGLL 166

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           + ISGFGGSLLSALFIQSNISV              SELITNW+IY NK+
Sbjct: 167 FFISGFGGSLLSALFIQSNISVGASGALFGLLGGMLSELITNWSIYDNKL 216


>gb|EMJ06522.1| hypothetical protein PRUPE_ppa006931mg [Prunus persica]
          Length = 389

 Score =  159 bits (401), Expect = 5e-37
 Identities = 79/109 (72%), Positives = 88/109 (80%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           L+KMGALDV KVV  H+GW LITC WLHGGVFHLLANMLSL+VIG RLEQEFGFVRIGL+
Sbjct: 112 LQKMGALDVNKVVHRHQGWLLITCNWLHGGVFHLLANMLSLLVIGYRLEQEFGFVRIGLI 171

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANK 48
           Y+ISG GGSLLS+LFIQ+NISV              SEL+TNWTIYA+K
Sbjct: 172 YVISGLGGSLLSSLFIQTNISVGASGALFGLLGAMLSELVTNWTIYASK 220


>ref|XP_004156648.1| PREDICTED: uncharacterized protein LOC101224387 [Cucumis sativus]
          Length = 471

 Score =  158 bits (399), Expect = 8e-37
 Identities = 80/110 (72%), Positives = 90/110 (81%)
 Frame = -3

Query: 374 LEKMGALDVGKVVDEHEGWRLITCMWLHGGVFHLLANMLSLIVIGIRLEQEFGFVRIGLL 195
           L +MGAL+V KVV  ++ WRLITC+WLH GVFHLLANMLSL+VIGIRLEQEFGF+RIGLL
Sbjct: 194 LRRMGALEVNKVVHGNQLWRLITCIWLHAGVFHLLANMLSLLVIGIRLEQEFGFIRIGLL 253

Query: 194 YLISGFGGSLLSALFIQSNISVXXXXXXXXXXXXXXSELITNWTIYANKV 45
           Y+ISGFGGSLLS+LFIQSNISV              SELITNWTIY+NKV
Sbjct: 254 YVISGFGGSLLSSLFIQSNISVGASGALFGLLGGMLSELITNWTIYSNKV 303