BLASTX 2.2.26 [Sep-21-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Panax25_contig00002758
         (1421 letters)

Database: ./nr 
           115,041,592 sequences; 42,171,959,267 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

XP_017241904.1 PREDICTED: DNA topoisomerase 1-like [Daucus carot...   218   4e-59
CAB46363.1 DNA topoisomerase I [Daucus carota]                        199   4e-52
P93119.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA to...   132   1e-50
BAG31376.1 topoisomerase I [Camptotheca acuminata]                    190   4e-49
XP_016684952.1 PREDICTED: DNA topoisomerase 1-like [Gossypium hi...   172   6e-43
XP_017606412.1 PREDICTED: DNA topoisomerase 1-like [Gossypium ar...   172   6e-43
KJB62948.1 hypothetical protein B456_009G444700 [Gossypium raimo...   171   2e-42
XP_012443903.1 PREDICTED: DNA topoisomerase 1-like [Gossypium ra...   171   3e-42
XP_016720339.1 PREDICTED: DNA topoisomerase 1-like [Gossypium hi...   170   5e-42
EOY12191.1 DNA topoisomerase I alpha isoform 3 [Theobroma cacao]...   167   4e-41
EOY12189.1 DNA topoisomerase I alpha isoform 1 [Theobroma cacao]...   167   5e-41
BAG31377.1 topoisomerase I [Catharanthus roseus]                      166   1e-40
KMZ57043.1 DNA topoisomerase 1 [Zostera marina]                       114   1e-40
XP_010266803.1 PREDICTED: DNA topoisomerase 1 alpha-like [Nelumb...   164   3e-40
XP_017980434.1 PREDICTED: DNA topoisomerase 1 [Theobroma cacao] ...   163   8e-40
XP_010252639.1 PREDICTED: DNA topoisomerase 1 alpha-like [Nelumb...   160   7e-39
KVH96852.1 DNA breaking-rejoining enzyme, catalytic core [Cynara...   153   2e-36
XP_016513485.1 PREDICTED: DNA topoisomerase 1-like [Nicotiana ta...   153   3e-36
XP_009619726.2 PREDICTED: DNA topoisomerase 1-like [Nicotiana to...   152   5e-36
XP_016480590.1 PREDICTED: DNA topoisomerase 1-like isoform X2 [N...   151   1e-35

>XP_017241904.1 PREDICTED: DNA topoisomerase 1-like [Daucus carota subsp. sativus]
            KZN00059.1 hypothetical protein DCAR_008813 [Daucus
            carota subsp. sativus]
          Length = 895

 Score =  218 bits (556), Expect = 4e-59
 Identities = 154/329 (46%), Positives = 186/329 (56%), Gaps = 31/329 (9%)
 Frame = -2

Query: 1165 MMNTSDDEDDMPLVFKRSAAS-KQNQLNPEVKKSLSQKHDX------------------- 1046
            M + SD EDD PL+FKRS  S KQNQ  P+VKKS  QK D                    
Sbjct: 1    MEHGSDSEDDKPLIFKRSNTSVKQNQAKPDVKKSSVQKPDGKSGRPISDVRSTNGHDSNV 60

Query: 1045 -----VLSTKGXXXXXXXXXXXXXXXXXXXXXXXXXVENTKASTSAADQSKINSQQTKTT 881
                 V STKG                         V +TKASTS ADQS+ NSQQ +T 
Sbjct: 61   QKGKTVPSTKGSPVVSPLASPKASVSSSKASQVKPPVGSTKASTSGADQSRQNSQQNRTA 120

Query: 880  IVKVEKSLGKPXXXXXXXXXXXXXDKPLSFRLSAGASKGS-SNVNKGPDSSGFVSSALPK 704
            IVK E+  G P             DKPL+ RL  G SKGS S VN+ P SSG   +AL K
Sbjct: 121  IVKAERPSGIPKEEPDSGSEDSDDDKPLNSRLPVGGSKGSISEVNRRPSSSG--PAALAK 178

Query: 703  P-RVKEEDSEDEKPLSMKFQLKTNVGTSISNSYDSDENKPIASRLQLNGSGIRGNQVMKS 527
               +KEEDSED+ PLS KF+ K+N G S SN+YDSDE KP AS+ + NG+ ++ N V   
Sbjct: 179  DLGIKEEDSEDDIPLSHKFKQKSNAGES-SNAYDSDEGKPFASKPRQNGTNVKDN-VKNP 236

Query: 526  SIALNKRPSAEAKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMTK--DDVDDHVPISQR 353
            S A+NKRPSAE K SGQ  VKKAK + A    N K+V VKAE   +  D  DD+  ISQR
Sbjct: 237  STAINKRPSAEVKCSGQSPVKKAKHTAASTPVNGKKVTVKAEPKKEADDSDDDNATISQR 296

Query: 352  IKKLATPVSKLSDKKKT--TVSYSVNRIN 272
            +KK ATP+SK SDKKK+  +VS S+N++N
Sbjct: 297  VKKPATPISKASDKKKSAVSVSSSLNKVN 325



 Score =  131 bits (329), Expect = 6e-29
 Identities = 59/74 (79%), Positives = 66/74 (89%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLYKG+PVDLTPEQEEVATMIAVM DT+Y  KP FREN M+DWKKILG+NHII+N +
Sbjct: 371 GVKMLYKGKPVDLTPEQEEVATMIAVMQDTEYMTKPVFRENVMNDWKKILGRNHIIKNLD 430

Query: 44  DCNFQPIYEWHQRE 3
           DC+F PIYEWHQ E
Sbjct: 431 DCDFTPIYEWHQTE 444


>CAB46363.1 DNA topoisomerase I [Daucus carota]
          Length = 909

 Score =  199 bits (505), Expect = 4e-52
 Identities = 142/327 (43%), Positives = 175/327 (53%), Gaps = 29/327 (8%)
 Frame = -2

Query: 1165 MMNTSDDEDDMPLVFKRSAAS-KQNQLNPEVKKSLS------------------------ 1061
            M + SD EDD PL+FKRS  S KQNQ  P  +K +S                        
Sbjct: 1    MEHGSDSEDDKPLIFKRSNTSVKQNQAKPRCQKIISAEAVWQVGRLISDVRSTNGHDSNV 60

Query: 1060 QKHDXVLSTKGXXXXXXXXXXXXXXXXXXXXXXXXXVENTKASTSAADQSKINSQQTKTT 881
            QK   V STKG                         V +TKASTS ADQS+ NSQQ +T 
Sbjct: 61   QKGKTVPSTKGSPVVSPLASPKASVSSSKASQVKPPVASTKASTSGADQSRQNSQQNRTA 120

Query: 880  IVKVEKSLGKPXXXXXXXXXXXXXDKPLSFRLSAGASKGS-SNVNKGPDSSGFVSSALPK 704
            IVK E+  G P             DKPL+ RL  G SKGS S VN+ P SSG   +A  K
Sbjct: 121  IVKAERPSGIPKEEPDSGSEDSDDDKPLNSRLPVGGSKGSISEVNRRPSSSG--PAAFEK 178

Query: 703  P-RVKEEDSEDEKPLSMKFQLKTNVGTSISNSYDSDENKPIASRLQLNGSGIRGNQVMKS 527
               +KEEDSED+ PLS KF+ K+N G S SN+YDSDE KP AS+ + NG+ ++ N V   
Sbjct: 179  DLGIKEEDSEDDIPLSHKFKQKSNAGES-SNAYDSDEGKPFASKPRQNGTNVKDN-VKNP 236

Query: 526  SIALNKRPSAEAKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMTKDDVDDHVPISQRIK 347
            S A+NKRPSAE K SGQ  VKKA +           V  + +    D  DD+  ISQR+K
Sbjct: 237  STAINKRPSAEVKCSGQSPVKKATVQLHLHQVRKLTVKAEPKKEADDSDDDNATISQRVK 296

Query: 346  KLATPVSKLSDKKKT--TVSYSVNRIN 272
            K ATP+SK SDKKK+  +VS S+N++N
Sbjct: 297  KPATPISKASDKKKSAVSVSSSLNKVN 323



 Score = 97.4 bits (241), Expect = 9e-18
 Identities = 44/70 (62%), Positives = 53/70 (75%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLYK  PVDLT  QEEV  +  + + T+Y  KP FREN M+DWK ILG+NHII+N +
Sbjct: 369 GVKMLYKESPVDLTLNQEEVHMIAVMQILTEYLTKPVFRENVMNDWKIILGRNHIIKNLD 428

Query: 44  DCNFQPIYEW 15
           DC+F PIYEW
Sbjct: 429 DCDFTPIYEW 438


>P93119.1 RecName: Full=DNA topoisomerase 1; AltName: Full=DNA topoisomerase
           I AAB41401.1 topoisomerase I [Daucus carota]
          Length = 790

 Score =  132 bits (331), Expect(2) = 1e-50
 Identities = 59/74 (79%), Positives = 65/74 (87%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLY+  PVDLTPEQEEVATM AVML+T+Y  KPKFRENFMSDW+KILG+ HIIQN  
Sbjct: 235 GVKMLYRENPVDLTPEQEEVATMFAVMLETEYMTKPKFRENFMSDWRKILGEKHIIQNLE 294

Query: 44  DCNFQPIYEWHQRE 3
           DC+F PIYEWHQRE
Sbjct: 295 DCDFTPIYEWHQRE 308



 Score = 98.2 bits (243), Expect(2) = 1e-50
 Identities = 75/180 (41%), Positives = 99/180 (55%), Gaps = 2/180 (1%)
 Frame = -2

Query: 805 KPLSFRLSAGASKGSSN-VNKGPDSSGFVSSALPKPRVKEEDSEDEKPLSMKFQLKTNVG 629
           KPLS +LS+GA  G+S+ +  G + S       PKPR+ +   EDE  LS + QL  N G
Sbjct: 39  KPLSHKLSSGALNGNSHHIRMGSNLSCPSPYTSPKPRIIK-GPEDEMLLSSELQL--NAG 95

Query: 628 TSISNSYDSDENKPIASRLQLNGSGIRGNQVMKSSIALNKRPSAEAKSSGQYSVKKAKLS 449
            S + S DSDE+KP+AS L+              S +LNKRP  + K+S     KKAKLS
Sbjct: 96  ASNAESSDSDESKPLASELE------------DPSSSLNKRPLIQPKNSDPSPSKKAKLS 143

Query: 448 DAPASSNSKQVNVKAELMTKDDVDDHVPISQRIKKLATPVSKLSDKKK-TTVSYSVNRIN 272
           +  A +N K   +K     +   DD   IS R KK  TP SK+SDKKK   VS SVN+++
Sbjct: 144 EPSAPTNRK---LKTAEQEEAAADDDPSISNRNKKSTTPASKVSDKKKRPDVSASVNKVD 200


>BAG31376.1 topoisomerase I [Camptotheca acuminata]
          Length = 894

 Score =  190 bits (483), Expect = 4e-49
 Identities = 138/309 (44%), Positives = 164/309 (53%), Gaps = 21/309 (6%)
 Frame = -2

Query: 1168 EMMNTSDDEDDMPLVFKRS-AASKQNQLNPEVKKSLSQKHDX--------VLSTKGXXXX 1016
            E M    DEDD PLVFKRS A SK NQLN + KKS SQ++D         V ST G    
Sbjct: 9    EKMMDEIDEDDEPLVFKRSNATSKHNQLNSDTKKS-SQRYDGQSGRQVSDVPSTNGQSSS 67

Query: 1015 XXXXXXXXXXXXXXXXXXXXXVE---------NTKASTSAADQSKINSQQTKTTIVKVEK 863
                                            N K S+S+ D+SK +S+Q    +VK EK
Sbjct: 68   ASKGKTTKLSSMKSPIASPKASTSFAKASPVANPKVSSSSDDRSKHSSKQNTINVVKEEK 127

Query: 862  SLGKPXXXXXXXXXXXXXDKPLSFRLSAGASKGSSN-VNKGPDSSGFVSSALPKPRVKE- 689
             L  P              KPLS RL  G +KGSSN  NKG  +S   S  +PKP +   
Sbjct: 128  ELVNPAAEPYGDSEDE---KPLSARLFTGLTKGSSNNANKGLINSSPASLPVPKPEINRY 184

Query: 688  -EDSEDEKPLSMKFQLKTNVGTSISNSYDSDENKPIASRLQLNGSGIRGNQVMKSSIALN 512
             +DS+DE PLS KF+LK N GTS   SY+SD+NK + S  Q NGS  RG+   KSSI +N
Sbjct: 185  SDDSDDEIPLSSKFRLKANAGTSTVKSYESDDNKTLVSNFQQNGSINRGS---KSSIKVN 241

Query: 511  KRPSAEAKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMTKDDVDDHVPISQRIKKLATP 332
            KRP  E KSS Q SVKK KLSDA    N+KQ + KAE    D  DDHVPISQR+KK AT 
Sbjct: 242  KRPLGEVKSSVQSSVKKPKLSDASTPVNNKQASKKAEPKADDSDDDHVPISQRMKKSATS 301

Query: 331  VSKLSDKKK 305
             +K S  K+
Sbjct: 302  GNKSSTAKQ 310



 Score =  137 bits (345), Expect = 6e-31
 Identities = 61/74 (82%), Positives = 66/74 (89%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLYKG+PVDLTPEQEEVATM AVMLDTDY  K KF+ENFM DW+KILGKNH+IQN  
Sbjct: 370 GVKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMTKSKFKENFMDDWRKILGKNHVIQNLE 429

Query: 44  DCNFQPIYEWHQRE 3
           DC+F PIYEWHQRE
Sbjct: 430 DCDFTPIYEWHQRE 443


>XP_016684952.1 PREDICTED: DNA topoisomerase 1-like [Gossypium hirsutum]
            XP_016684953.1 PREDICTED: DNA topoisomerase 1-like
            [Gossypium hirsutum] XP_016684954.1 PREDICTED: DNA
            topoisomerase 1-like [Gossypium hirsutum] XP_016684955.1
            PREDICTED: DNA topoisomerase 1-like [Gossypium hirsutum]
            XP_016684956.1 PREDICTED: DNA topoisomerase 1-like
            [Gossypium hirsutum] XP_016684957.1 PREDICTED: DNA
            topoisomerase 1-like [Gossypium hirsutum] XP_016684958.1
            PREDICTED: DNA topoisomerase 1-like [Gossypium hirsutum]
            XP_016684959.1 PREDICTED: DNA topoisomerase 1-like
            [Gossypium hirsutum]
          Length = 901

 Score =  172 bits (437), Expect = 6e-43
 Identities = 129/324 (39%), Positives = 168/324 (51%), Gaps = 31/324 (9%)
 Frame = -2

Query: 1150 DDEDDMPLVFKRS--AASKQNQLNPEVKKSLSQKHDX----------------------- 1046
            D++DD P+VFKRS  ++SKQNQLN EVKK+ SQ+ D                        
Sbjct: 15   DEDDDGPVVFKRSNTSSSKQNQLNSEVKKASSQRSDGQSGRQASSLQSPNGQNSVARTNK 74

Query: 1045 -VLSTKGXXXXXXXXXXXXXXXXXXXXXXXXXVENTKASTSAADQSKINSQQTKTTIVKV 869
             +L +K                          V ++KASTS +DQSK   +Q K T VK 
Sbjct: 75   SILPSKSPPTRSPILSPKSSNSSAKASPVRSPVVSSKASTSLSDQSKQALKQNKFTAVKE 134

Query: 868  EKSLGKPXXXXXXXXXXXXXDKPLSFRLSAGASKGSSNVNKGPDSSGFVSSALPKPRVK- 692
            EKSL K               KPLS RL   +S+G+  V+    +       +PK  VK 
Sbjct: 135  EKSLIK-CTDETNSDDDDDDSKPLSARLKGISSQGNKGVSTSTPAQS--QRLVPKIEVKG 191

Query: 691  -EEDSEDEKPLSMKFQLKTNVGTSISNSYDSDENKPIASRLQLNGSGIRGNQVMKSSIAL 515
              ED +D+ PLS +F +K+N GTS S  Y S E KP+ S++Q NGS ++  Q  K S+  
Sbjct: 192  SAEDPDDDAPLSARFSMKSNTGTSSSKPYGSHEKKPLPSKIQQNGSIMKDKQ-QKCSVLS 250

Query: 514  NKRPSAEAKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMTKDDVDDHVPISQRIKKLAT 335
            +KRP  +  SS Q   KK K+SD P +  +KQV VKAE   KDD DDH+PISQRIKK  +
Sbjct: 251  DKRPLDKGNSSDQSYAKKPKISDTPTTMKTKQVTVKAE---KDDEDDHIPISQRIKKSVS 307

Query: 334  PVSKLSD-KKKTT--VSYSVNRIN 272
             VSK S  K+K T  VS S  +IN
Sbjct: 308  SVSKTSSVKQKATKVVSSSFKKIN 331



 Score =  118 bits (295), Expect = 1e-24
 Identities = 50/74 (67%), Positives = 62/74 (83%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLY GQPVDLTPEQEEVATM AVM +TDY  KP+F++NF  DW K+LG+NH+I++ +
Sbjct: 377 GVKMLYDGQPVDLTPEQEEVATMFAVMQETDYMSKPQFKKNFWEDWSKLLGRNHVIKSLD 436

Query: 44  DCNFQPIYEWHQRE 3
            C+F PIYEWH +E
Sbjct: 437 KCDFTPIYEWHLQE 450


>XP_017606412.1 PREDICTED: DNA topoisomerase 1-like [Gossypium arboreum]
            XP_017606413.1 PREDICTED: DNA topoisomerase 1-like
            [Gossypium arboreum] XP_017606414.1 PREDICTED: DNA
            topoisomerase 1-like [Gossypium arboreum] XP_017606415.1
            PREDICTED: DNA topoisomerase 1-like [Gossypium arboreum]
            XP_017606416.1 PREDICTED: DNA topoisomerase 1-like
            [Gossypium arboreum] XP_017606417.1 PREDICTED: DNA
            topoisomerase 1-like [Gossypium arboreum] KHG20024.1 DNA
            topoisomerase 1 -like protein [Gossypium arboreum]
          Length = 903

 Score =  172 bits (437), Expect = 6e-43
 Identities = 135/339 (39%), Positives = 172/339 (50%), Gaps = 33/339 (9%)
 Frame = -2

Query: 1189 ALVGAKPEMMNTSDDEDDMPLVFKRS--AASKQNQLNPEVKKSLSQKHDX---------- 1046
            A+      + +  D++DD P+VFKRS  ++SKQNQLN EVKK+ SQ+ D           
Sbjct: 2    AVEAPSKHVFDYDDEDDDGPVVFKRSNTSSSKQNQLNSEVKKASSQRSDGQSGRQASSVR 61

Query: 1045 --------------VLSTKGXXXXXXXXXXXXXXXXXXXXXXXXXVENTKASTSAADQSK 908
                          +  +K                          V ++KASTS  DQSK
Sbjct: 62   APNGQNSVAQTNKSIPPSKSPPIRSPILSPKSSNSSSKASPVRSPVVSSKASTSFNDQSK 121

Query: 907  INSQQTKTTIVKVEKSLGKPXXXXXXXXXXXXXDKPLSFRLSAGASKGSSNVNKGPDSSG 728
              S+Q K T VK EKS  K               KPLS RL   +S+G    NKG  +S 
Sbjct: 122  QASKQNKFTAVKEEKSPIKRTDETNSDDDDDDDSKPLSARLKGISSQG----NKGVSTST 177

Query: 727  FVSSA--LPKPRVK--EEDSEDEKPLSMKFQLKTNVGTSISNSYDSDENKPIASRLQLNG 560
               S   +PK  VK   ED +D+ PLS +F  K+N GTS S  Y S E KP+AS++Q NG
Sbjct: 178  PAQSQRFVPKIEVKGSAEDPDDDAPLSARFSTKSNTGTSSSKPYGSHEKKPLASKIQQNG 237

Query: 559  SGIRGNQVMKSSIALNKRPSAEAKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMTKDDV 380
            S ++  Q  KSS+  +KRP  +  SS Q   KK K+SD P    +KQV VKAE   KDD 
Sbjct: 238  SIMKVKQ-QKSSMLSDKRPLDKGNSSDQSYAKKPKISDTPTMMKTKQVTVKAE---KDDE 293

Query: 379  DDHVPISQRIKKLATPVSKLSD-KKKTT--VSYSVNRIN 272
            DDH+PISQRIKK  + VSK S  K+K T  VS S  +IN
Sbjct: 294  DDHIPISQRIKKSVSSVSKASSVKQKATKVVSSSFKKIN 332



 Score =  116 bits (291), Expect = 4e-24
 Identities = 49/74 (66%), Positives = 62/74 (83%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLY G+PVDLTPEQEEVATM AVM +TDY  KP+F++NF  DW K+LG+NH+I++ +
Sbjct: 379 GVKMLYDGRPVDLTPEQEEVATMFAVMQETDYMSKPQFKKNFWEDWSKLLGRNHVIKSLD 438

Query: 44  DCNFQPIYEWHQRE 3
            C+F PIYEWH +E
Sbjct: 439 KCDFTPIYEWHLQE 452


>KJB62948.1 hypothetical protein B456_009G444700 [Gossypium raimondii]
          Length = 823

 Score =  171 bits (432), Expect = 2e-42
 Identities = 128/324 (39%), Positives = 167/324 (51%), Gaps = 31/324 (9%)
 Frame = -2

Query: 1150 DDEDDMPLVFKRS--AASKQNQLNPEVKKSLSQKHDX----------------------- 1046
            D++DD P+VFKRS  ++SKQNQLN EVKK+ SQ+ D                        
Sbjct: 15   DEDDDGPVVFKRSNTSSSKQNQLNSEVKKASSQRSDGQSGRQASSVQAPNGQNSVAWTNK 74

Query: 1045 -VLSTKGXXXXXXXXXXXXXXXXXXXXXXXXXVENTKASTSAADQSKINSQQTKTTIVKV 869
             +L +K                          V ++KASTS +DQSK   +Q K T VK 
Sbjct: 75   SILPSKSPPTRSPILSPKSSNSSAKASPVRSPVVSSKASTSLSDQSKQALKQNKFTAVKE 134

Query: 868  EKSLGKPXXXXXXXXXXXXXDKPLSFRLSAGASKGSSNVNKGPDSSGFVSSALPKPRVK- 692
            EK L K               KPLS RL   +S+G+  V+    +       +PK  VK 
Sbjct: 135  EKRLIK-CTDETNSDEDDDDSKPLSARLKGISSQGNKGVSTSTPAQS--QRLVPKIEVKG 191

Query: 691  -EEDSEDEKPLSMKFQLKTNVGTSISNSYDSDENKPIASRLQLNGSGIRGNQVMKSSIAL 515
              ED +D+ PLS +F +K+N GTS S  Y S E KP+ S++Q NGS ++  Q  K S+  
Sbjct: 192  SAEDPDDDAPLSARFSMKSNTGTSSSKPYGSHEKKPLPSKIQQNGSIMKDKQ-QKCSVLS 250

Query: 514  NKRPSAEAKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMTKDDVDDHVPISQRIKKLAT 335
            +KRP  +  SS Q   KK K+SD P +  +KQV VKAE   KDD DDH+PISQRIKK  +
Sbjct: 251  DKRPLDKGNSSDQSYAKKPKISDTPTTMKTKQVTVKAE---KDDEDDHIPISQRIKKSVS 307

Query: 334  PVSKLSD-KKKTT--VSYSVNRIN 272
             VSK S  K+K T  VS S  +IN
Sbjct: 308  SVSKTSSVKQKATKVVSSSFKKIN 331



 Score =  118 bits (295), Expect = 1e-24
 Identities = 50/74 (67%), Positives = 62/74 (83%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLY GQPVDLTPEQEEVATM AVM +TDY  KP+F++NF  DW K+LG+NH+I++ +
Sbjct: 377 GVKMLYDGQPVDLTPEQEEVATMFAVMQETDYMSKPQFKKNFWEDWSKLLGRNHVIKSLD 436

Query: 44  DCNFQPIYEWHQRE 3
            C+F PIYEWH +E
Sbjct: 437 KCDFTPIYEWHLQE 450


>XP_012443903.1 PREDICTED: DNA topoisomerase 1-like [Gossypium raimondii]
            XP_012443904.1 PREDICTED: DNA topoisomerase 1-like
            [Gossypium raimondii] XP_012443905.1 PREDICTED: DNA
            topoisomerase 1-like [Gossypium raimondii] XP_012443906.1
            PREDICTED: DNA topoisomerase 1-like [Gossypium raimondii]
            XP_012443907.1 PREDICTED: DNA topoisomerase 1-like
            [Gossypium raimondii] XP_012443908.1 PREDICTED: DNA
            topoisomerase 1-like [Gossypium raimondii] XP_012443909.1
            PREDICTED: DNA topoisomerase 1-like [Gossypium raimondii]
            XP_012443910.1 PREDICTED: DNA topoisomerase 1-like
            [Gossypium raimondii] KJB62946.1 hypothetical protein
            B456_009G444700 [Gossypium raimondii] KJB62947.1
            hypothetical protein B456_009G444700 [Gossypium
            raimondii] KJB62949.1 hypothetical protein
            B456_009G444700 [Gossypium raimondii]
          Length = 901

 Score =  171 bits (432), Expect = 3e-42
 Identities = 128/324 (39%), Positives = 167/324 (51%), Gaps = 31/324 (9%)
 Frame = -2

Query: 1150 DDEDDMPLVFKRS--AASKQNQLNPEVKKSLSQKHDX----------------------- 1046
            D++DD P+VFKRS  ++SKQNQLN EVKK+ SQ+ D                        
Sbjct: 15   DEDDDGPVVFKRSNTSSSKQNQLNSEVKKASSQRSDGQSGRQASSVQAPNGQNSVAWTNK 74

Query: 1045 -VLSTKGXXXXXXXXXXXXXXXXXXXXXXXXXVENTKASTSAADQSKINSQQTKTTIVKV 869
             +L +K                          V ++KASTS +DQSK   +Q K T VK 
Sbjct: 75   SILPSKSPPTRSPILSPKSSNSSAKASPVRSPVVSSKASTSLSDQSKQALKQNKFTAVKE 134

Query: 868  EKSLGKPXXXXXXXXXXXXXDKPLSFRLSAGASKGSSNVNKGPDSSGFVSSALPKPRVK- 692
            EK L K               KPLS RL   +S+G+  V+    +       +PK  VK 
Sbjct: 135  EKRLIK-CTDETNSDEDDDDSKPLSARLKGISSQGNKGVSTSTPAQS--QRLVPKIEVKG 191

Query: 691  -EEDSEDEKPLSMKFQLKTNVGTSISNSYDSDENKPIASRLQLNGSGIRGNQVMKSSIAL 515
              ED +D+ PLS +F +K+N GTS S  Y S E KP+ S++Q NGS ++  Q  K S+  
Sbjct: 192  SAEDPDDDAPLSARFSMKSNTGTSSSKPYGSHEKKPLPSKIQQNGSIMKDKQ-QKCSVLS 250

Query: 514  NKRPSAEAKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMTKDDVDDHVPISQRIKKLAT 335
            +KRP  +  SS Q   KK K+SD P +  +KQV VKAE   KDD DDH+PISQRIKK  +
Sbjct: 251  DKRPLDKGNSSDQSYAKKPKISDTPTTMKTKQVTVKAE---KDDEDDHIPISQRIKKSVS 307

Query: 334  PVSKLSD-KKKTT--VSYSVNRIN 272
             VSK S  K+K T  VS S  +IN
Sbjct: 308  SVSKTSSVKQKATKVVSSSFKKIN 331



 Score =  118 bits (295), Expect = 1e-24
 Identities = 50/74 (67%), Positives = 62/74 (83%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLY GQPVDLTPEQEEVATM AVM +TDY  KP+F++NF  DW K+LG+NH+I++ +
Sbjct: 377 GVKMLYDGQPVDLTPEQEEVATMFAVMQETDYMSKPQFKKNFWEDWSKLLGRNHVIKSLD 436

Query: 44  DCNFQPIYEWHQRE 3
            C+F PIYEWH +E
Sbjct: 437 KCDFTPIYEWHLQE 450


>XP_016720339.1 PREDICTED: DNA topoisomerase 1-like [Gossypium hirsutum]
            XP_016720340.1 PREDICTED: DNA topoisomerase 1-like
            [Gossypium hirsutum] XP_016720342.1 PREDICTED: DNA
            topoisomerase 1-like [Gossypium hirsutum]
          Length = 897

 Score =  170 bits (430), Expect = 5e-42
 Identities = 136/335 (40%), Positives = 173/335 (51%), Gaps = 29/335 (8%)
 Frame = -2

Query: 1189 ALVGAKPEMMNTSDDEDDMPLVFKRS--AASKQNQLNPEVKKSLSQKHDX--------VL 1040
            A+      + +  D++DD P+VFKRS  ++SKQNQLN EVKK+ SQ+ D         V 
Sbjct: 2    AVEAPSKHVFDYDDEDDDGPVVFKRSNTSSSKQNQLNSEVKKASSQRSDRQSGRQASSVR 61

Query: 1039 STKGXXXXXXXXXXXXXXXXXXXXXXXXXVENT------------KASTSAADQSKINSQ 896
            +  G                          +++            KASTS  DQSK  S+
Sbjct: 62   APNGQNSVAQTNKSIPPSKSPPIRSPILSPKSSNSSSKASPVVSSKASTSFNDQSKQASK 121

Query: 895  QTKTTIVKVEKSLGKPXXXXXXXXXXXXXDKPLSFRLSAGASKGSSNVNKGPDSSGFVSS 716
            Q K T VK EKS  K               KPLS RL   +S+G    NKG  +S    S
Sbjct: 122  QNKFTAVKEEKSPIK--CTDETNSDDDDDSKPLSARLKGISSQG----NKGVSTSTPAQS 175

Query: 715  A--LPKPRVK--EEDSEDEKPLSMKFQLKTNVGTSISNSYDSDENKPIASRLQLNGSGIR 548
               +PK  VK   ED +D+ PLS +F  K+N GTS S  Y S E KP+AS++Q NGS ++
Sbjct: 176  QRFVPKIEVKGSAEDPDDDAPLSARFSTKSNTGTSSSKPYGSHEKKPLASKIQQNGSIMK 235

Query: 547  GNQVMKSSIALNKRPSAEAKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMTKDDVDDHV 368
              Q  KSS+  +KRP  +  SS Q   KK K+SDAP    +KQV VKAE   KDD DDH+
Sbjct: 236  VKQ-QKSSMLSDKRPLDKGNSSDQSYAKKPKISDAPTMMKTKQVTVKAE---KDDEDDHI 291

Query: 367  PISQRIKKLATPVSKLSD-KKKTT--VSYSVNRIN 272
            PISQRIKK  + VSK S  K+K T  VS S  +IN
Sbjct: 292  PISQRIKKSVSSVSKASSVKQKATKVVSSSFKKIN 326



 Score =  116 bits (291), Expect = 4e-24
 Identities = 49/74 (66%), Positives = 62/74 (83%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLY G+PVDLTPEQEEVATM AVM +TDY  KP+F++NF  DW K+LG+NH+I++ +
Sbjct: 373 GVKMLYDGRPVDLTPEQEEVATMFAVMQETDYMSKPQFKKNFWEDWSKLLGRNHVIKSLD 432

Query: 44  DCNFQPIYEWHQRE 3
            C+F PIYEWH +E
Sbjct: 433 KCDFTPIYEWHLQE 446


>EOY12191.1 DNA topoisomerase I alpha isoform 3 [Theobroma cacao] EOY12193.1 DNA
            topoisomerase I alpha isoform 3 [Theobroma cacao]
          Length = 836

 Score =  167 bits (422), Expect = 4e-41
 Identities = 130/326 (39%), Positives = 165/326 (50%), Gaps = 33/326 (10%)
 Frame = -2

Query: 1150 DDEDDMPLVFKRS--AASKQNQLNPEVKKSLSQKHDX----------------------- 1046
            DD+DD P+VFKR+  ++SKQNQLN EVKK+ SQ+ D                        
Sbjct: 15   DDDDDGPVVFKRNNTSSSKQNQLNSEVKKASSQRSDGQSGRQVSDVRSPNGQSSNAPKNK 74

Query: 1045 -VLSTKGXXXXXXXXXXXXXXXXXXXXXXXXXVENTKASTSAADQSKINSQQTKTTIVKV 869
             + S+K                          V N KASTS  DQSK   +Q  TT VK 
Sbjct: 75   SISSSKSPPVKSPILSPKASTSSTKALPVKSPVVNFKASTSLNDQSKQALKQNMTTAVKE 134

Query: 868  EKSLGKPXXXXXXXXXXXXXDKPLSFRLSAGASKGSSNVNKGPDSSGFVSSA--LPKPRV 695
             +S  K                PLS RL   +++G    NKG  +S    S   +PK  V
Sbjct: 135  GRSPIKGTTEPNSDDDDDDDSLPLSARLKGISNQG----NKGASTSAPAQSRRLVPKTEV 190

Query: 694  K--EEDSEDEKPLSMKFQLKTNVGTSISNSYDSDENKPIASRLQLNGSGIRGNQVMKSSI 521
            K   ED +DE PLS +F +K+N GTS S  +D DE KP+AS++Q NGS ++G Q   SS 
Sbjct: 191  KVSAEDPDDEAPLSARFNVKSNTGTSSSRLHDCDEKKPLASKIQQNGSIMKGKQ-QNSST 249

Query: 520  ALNKRPSAEAKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMTKDDVDDHVPISQRIKKL 341
               KRP  +  SS   S KK K SDAP +  +KQV VKAE    D+ DDH+PI+QR+KK 
Sbjct: 250  LSGKRPLDKGNSSDHSSAKKPKTSDAPTTMKTKQVTVKAE--KADEDDDHMPIAQRMKKS 307

Query: 340  ATPVSKLSD-KKKTT--VSYSVNRIN 272
                SKLS  K+KTT  VS S  +IN
Sbjct: 308  TASNSKLSSMKQKTTKVVSSSFKKIN 333



 Score =  114 bits (285), Expect = 2e-23
 Identities = 50/74 (67%), Positives = 60/74 (81%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLY G+PVDLTPEQEEVATM AVM DTDY  K +F++NF  DW K+LGKNH I++ +
Sbjct: 380 GVKMLYDGRPVDLTPEQEEVATMFAVMKDTDYMSKTQFKKNFWEDWSKLLGKNHTIKDLD 439

Query: 44  DCNFQPIYEWHQRE 3
            C+F PIYEWH +E
Sbjct: 440 RCDFTPIYEWHLQE 453


>EOY12189.1 DNA topoisomerase I alpha isoform 1 [Theobroma cacao] EOY12190.1 DNA
            topoisomerase I alpha isoform 1 [Theobroma cacao]
          Length = 904

 Score =  167 bits (422), Expect = 5e-41
 Identities = 130/326 (39%), Positives = 165/326 (50%), Gaps = 33/326 (10%)
 Frame = -2

Query: 1150 DDEDDMPLVFKRS--AASKQNQLNPEVKKSLSQKHDX----------------------- 1046
            DD+DD P+VFKR+  ++SKQNQLN EVKK+ SQ+ D                        
Sbjct: 15   DDDDDGPVVFKRNNTSSSKQNQLNSEVKKASSQRSDGQSGRQVSDVRSPNGQSSNAPKNK 74

Query: 1045 -VLSTKGXXXXXXXXXXXXXXXXXXXXXXXXXVENTKASTSAADQSKINSQQTKTTIVKV 869
             + S+K                          V N KASTS  DQSK   +Q  TT VK 
Sbjct: 75   SISSSKSPPVKSPILSPKASTSSTKALPVKSPVVNFKASTSLNDQSKQALKQNMTTAVKE 134

Query: 868  EKSLGKPXXXXXXXXXXXXXDKPLSFRLSAGASKGSSNVNKGPDSSGFVSSA--LPKPRV 695
             +S  K                PLS RL   +++G    NKG  +S    S   +PK  V
Sbjct: 135  GRSPIKGTTEPNSDDDDDDDSLPLSARLKGISNQG----NKGASTSAPAQSRRLVPKTEV 190

Query: 694  K--EEDSEDEKPLSMKFQLKTNVGTSISNSYDSDENKPIASRLQLNGSGIRGNQVMKSSI 521
            K   ED +DE PLS +F +K+N GTS S  +D DE KP+AS++Q NGS ++G Q   SS 
Sbjct: 191  KVSAEDPDDEAPLSARFNVKSNTGTSSSRLHDCDEKKPLASKIQQNGSIMKGKQ-QNSST 249

Query: 520  ALNKRPSAEAKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMTKDDVDDHVPISQRIKKL 341
               KRP  +  SS   S KK K SDAP +  +KQV VKAE    D+ DDH+PI+QR+KK 
Sbjct: 250  LSGKRPLDKGNSSDHSSAKKPKTSDAPTTMKTKQVTVKAE--KADEDDDHMPIAQRMKKS 307

Query: 340  ATPVSKLSD-KKKTT--VSYSVNRIN 272
                SKLS  K+KTT  VS S  +IN
Sbjct: 308  TASNSKLSSMKQKTTKVVSSSFKKIN 333



 Score =  114 bits (285), Expect = 3e-23
 Identities = 50/74 (67%), Positives = 60/74 (81%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLY G+PVDLTPEQEEVATM AVM DTDY  K +F++NF  DW K+LGKNH I++ +
Sbjct: 380 GVKMLYDGRPVDLTPEQEEVATMFAVMKDTDYMSKTQFKKNFWEDWSKLLGKNHTIKDLD 439

Query: 44  DCNFQPIYEWHQRE 3
            C+F PIYEWH +E
Sbjct: 440 RCDFTPIYEWHLQE 453


>BAG31377.1 topoisomerase I [Catharanthus roseus]
          Length = 910

 Score =  166 bits (420), Expect = 1e-40
 Identities = 107/228 (46%), Positives = 134/228 (58%), Gaps = 3/228 (1%)
 Frame = -2

Query: 946 NTKASTSAADQSKINSQQTKTTIVKVEKSLG-KPXXXXXXXXXXXXXDKPLSFRLSAGAS 770
           N+K STS + + K  +Q    T++K EKS   +               KPLS R SA +S
Sbjct: 122 NSKPSTSGSFKVKPFNQHKSATVIKEEKSSPLRLASAIINDSEDSDDGKPLSLRHSASSS 181

Query: 769 KGSSNVNKGPDSSGFVSSALPKPRVKEEDSEDEKPLSMKFQLKTNVGTSISNSYDSDENK 590
           KG++N          VS    KP  + EDS+DEKPLS +F LK+ VG S S +YDSD++K
Sbjct: 182 KGNTNQ---------VSKEGSKP--ENEDSDDEKPLSSRFPLKSGVGESTSKAYDSDDDK 230

Query: 589 PIASRLQLNGSGIRGNQVMKSSIALNKRPSAEAKSSGQYSVKKAKLSDAPASSNSKQVNV 410
           P+A +LQ NGS +R  Q  K S   NKRP  + KSS Q SVKK KLS   A +N KQ +V
Sbjct: 231 PLAKKLQHNGSAMRDGQPNKYSNMSNKRPPGDIKSSNQLSVKKPKLSSVTAPTNKKQASV 290

Query: 409 KAELMTKDDVDDHVPISQRIKKLATPVSKLSDKKKTT--VSYSVNRIN 272
           K E   +DD DDH+PISQRIKK  T  SK S  KKTT  VS SV ++N
Sbjct: 291 KPEPKAEDDDDDHLPISQRIKKSPTSESKSSSIKKTTKVVSSSVKKVN 338



 Score =  134 bits (338), Expect = 4e-30
 Identities = 58/74 (78%), Positives = 65/74 (87%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           G+KMLYKG+PVDLTPEQEEVATM AVMLDTDY  KP+F+ENF  DWKKILGKNH+IQN  
Sbjct: 384 GIKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMNKPRFKENFFGDWKKILGKNHVIQNLE 443

Query: 44  DCNFQPIYEWHQRE 3
           +C+F PIYEWHQ E
Sbjct: 444 NCDFSPIYEWHQSE 457


>KMZ57043.1 DNA topoisomerase 1 [Zostera marina]
          Length = 971

 Score =  114 bits (285), Expect(2) = 1e-40
 Identities = 50/74 (67%), Positives = 59/74 (79%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           G+K+LY G+PVDLTPEQEEVATM AVM DT+Y KK  F +NFMSDWK ILG NH+I+   
Sbjct: 445 GIKILYNGKPVDLTPEQEEVATMFAVMKDTEYAKKKTFLDNFMSDWKSILGANHVIKKLE 504

Query: 44  DCNFQPIYEWHQRE 3
            C+F PIY+WH RE
Sbjct: 505 LCDFTPIYDWHMRE 518



 Score = 82.4 bits (202), Expect(2) = 1e-40
 Identities = 59/140 (42%), Positives = 74/140 (52%), Gaps = 10/140 (7%)
 Frame = -2

Query: 661 SMKFQLKTNVGTSISNSYDSDENKPIASRLQLNGSGIRG-NQVMKSSIALNKRPSAEAKS 485
           S K    + +G+S   SYDS E KP AS +Q N S  R  N   KS I  NKRP     +
Sbjct: 274 SSKIPTNSGLGSSKKRSYDSIEKKPSASMIQQNSSFKREPNGASKSIINANKRPLGSILN 333

Query: 484 SGQYSVKKAKLSDAPA-SSNSKQVNVKAELMTKDDVDDHVPISQRIKKL--------ATP 332
           S Q S KK KLSD+PA S  +K++N+K E     D DD+VPIS++IKK         + P
Sbjct: 334 SVQSSNKKVKLSDSPAPSKTTKKLNLKEESRQSSDSDDYVPISRQIKKTISSNNKSPSKP 393

Query: 331 VSKLSDKKKTTVSYSVNRIN 272
           VSK    K      +V R N
Sbjct: 394 VSKRVISKPIQSEKNVKRSN 413


>XP_010266803.1 PREDICTED: DNA topoisomerase 1 alpha-like [Nelumbo nucifera]
          Length = 890

 Score =  164 bits (416), Expect = 3e-40
 Identities = 122/305 (40%), Positives = 160/305 (52%), Gaps = 13/305 (4%)
 Frame = -2

Query: 1174 KPEMMNTSDDEDDMPLVFKRS-AASKQNQLNPEVKKSLSQKHD-----XVLSTKGXXXXX 1013
            KP+  +  DD D+ P++FKR+ A+SK+NQLN E+KK  S+K D      V  +       
Sbjct: 9    KPKFFDDGDD-DEGPIIFKRNNASSKKNQLNKELKKVSSRKRDGSSGKCVSDSFSPNGQN 67

Query: 1012 XXXXXXXXXXXXXXXXXXXXVENTKASTSAADQSKINSQQTKTTIVKVEKSLGKPXXXXX 833
                                  ++KASTS  D+ K  S Q  ++I  +EK L KP     
Sbjct: 68   SSLQKGKAVQSSKASTGKSTETSSKASTSITDKLKC-SPQKNSSIDNMEKQLKKPCNEPY 126

Query: 832  XXXXXXXXDKPLSFRLSAGASK---GSSNVNKGPDSSGFVSSALPKPRV----KEEDSED 674
                    DKPLS RL   AS     SS V+KG  S    SS   K  V      EDSED
Sbjct: 127  TDSVDSDDDKPLSIRLPTSASLLKCKSSPVSKGLSSPVASSSQSEKTNVTNKKSSEDSED 186

Query: 673  EKPLSMKFQLKTNVGTSISNSYDSDENKPIASRLQLNGSGIRGNQVMKSSIALNKRPSAE 494
            E PLS+K +LK +VG S    YDS E KP+ S+LQ NGS  R N+ +KS   LNKRP + 
Sbjct: 187  ELPLSLKLKLKPSVGLSGKKFYDSGEEKPLVSKLQQNGSSKRDNEPLKSPKNLNKRPLSG 246

Query: 493  AKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMTKDDVDDHVPISQRIKKLATPVSKLSD 314
            A SSGQ  VKK K+S+    +  KQ ++K+E   K++ +D +PISQR+KK A+   K   
Sbjct: 247  ANSSGQSLVKKLKVSEVSVPTKVKQTSIKSE--PKEEDEDDIPISQRLKKSASSDDKSLS 304

Query: 313  KKKTT 299
             KKTT
Sbjct: 305  LKKTT 309



 Score =  122 bits (306), Expect = 6e-26
 Identities = 55/74 (74%), Positives = 62/74 (83%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLY G+PVDLTPEQEEVATM AVM DTDY  K +F ENFM+DW+ ILGKNH+I+ F 
Sbjct: 366 GVKMLYNGKPVDLTPEQEEVATMFAVMKDTDYATKSRFIENFMNDWRTILGKNHVIKKFE 425

Query: 44  DCNFQPIYEWHQRE 3
            C+F PIYEWHQRE
Sbjct: 426 LCDFTPIYEWHQRE 439


>XP_017980434.1 PREDICTED: DNA topoisomerase 1 [Theobroma cacao] XP_007020665.2
            PREDICTED: DNA topoisomerase 1 [Theobroma cacao]
          Length = 902

 Score =  163 bits (413), Expect = 8e-40
 Identities = 130/326 (39%), Positives = 165/326 (50%), Gaps = 33/326 (10%)
 Frame = -2

Query: 1150 DDEDDMPLVFKRS--AASKQNQLNPEVKKSLSQKHDX----------------------- 1046
            DD+DD P+VFKR+  ++SKQNQLN EVKK+ SQ+ D                        
Sbjct: 15   DDDDDGPVVFKRNNTSSSKQNQLNSEVKKASSQRSDGQSGRQVSDVRSPNGQSSNAPKNK 74

Query: 1045 -VLSTKGXXXXXXXXXXXXXXXXXXXXXXXXXVENTKASTSAADQSKINSQQTKTTIVKV 869
             + S+K                          V N KASTS  DQSK   +Q  TT VK 
Sbjct: 75   SISSSKSPPVKSPILSPKASTSSTKALPVKSPVVNFKASTSLNDQSKQALKQNMTTAVKE 134

Query: 868  EKSLGKPXXXXXXXXXXXXXDKPLSFRLSAGASKGSSNVNKGPDSSGFVSSA--LPKPRV 695
             +S  K                PLS RL   +++G    NKG  +S    S   +PK  V
Sbjct: 135  GRSPIKGTTEPNSDDDDDSL--PLSARLKGISNQG----NKGASTSAPAQSRRLVPKTEV 188

Query: 694  K--EEDSEDEKPLSMKFQLKTNVGTSISNSYDSDENKPIASRLQLNGSGIRGNQVMKSSI 521
            K   ED +DE PLS +F +K+N GTS S  +D DE KP+AS++Q NGS ++G Q   SS 
Sbjct: 189  KVSAEDPDDESPLSARFNVKSNTGTSSSRLHDCDEKKPLASKIQQNGSIMKGKQ-QNSST 247

Query: 520  ALNKRPSAEAKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMTKDDVDDHVPISQRIKKL 341
               KRP  +  SS   S KK K SDAP +  +KQV VKAE    D+ DDH+PI+QR+KK 
Sbjct: 248  LSGKRPLDKGNSSDHSSAKKPKTSDAPTTMKTKQVTVKAE--KADEDDDHMPIAQRMKKS 305

Query: 340  ATPVSKLSD-KKKTT--VSYSVNRIN 272
                SKLS  K+KTT  VS S  +IN
Sbjct: 306  TASNSKLSSMKQKTTKVVSSSFKKIN 331



 Score =  114 bits (285), Expect = 3e-23
 Identities = 50/74 (67%), Positives = 60/74 (81%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLY G+PVDLTPEQEEVATM AVM DTDY  K +F++NF  DW K+LGKNH I++ +
Sbjct: 378 GVKMLYDGRPVDLTPEQEEVATMFAVMKDTDYMSKTQFKKNFWEDWSKLLGKNHTIKDLD 437

Query: 44  DCNFQPIYEWHQRE 3
            C+F PIYEWH +E
Sbjct: 438 RCDFTPIYEWHLQE 451


>XP_010252639.1 PREDICTED: DNA topoisomerase 1 alpha-like [Nelumbo nucifera]
          Length = 883

 Score =  160 bits (406), Expect = 7e-39
 Identities = 115/305 (37%), Positives = 165/305 (54%), Gaps = 13/305 (4%)
 Frame = -2

Query: 1174 KPEMMNTSDDEDDMPLVFKRS-AASKQNQLNPEVKKSLSQKHDXVLS---TKGXXXXXXX 1007
            KP++++  DD+D+ P VFKR+  AS++NQ+N E+KK+ SQ++D       +         
Sbjct: 8    KPKIID-DDDDDEGPAVFKRNNTASRKNQVNSELKKASSQRNDGSSGKHVSGSLSPNGQN 66

Query: 1006 XXXXXXXXXXXXXXXXXXVENTKASTSAADQSKINSQQTKTTIVKVEKSLGKPXXXXXXX 827
                                ++ ASTS AD+S+ + Q+        ++ L KP       
Sbjct: 67   SSLQKGKAVSKTSAGKPTAASSNASTSIADKSRCSPQKNLAINNMQKQQLNKPCNGPKED 126

Query: 826  XXXXXXDKPLSFRLSAGASKGSSNVNKGPDSSGF---VSSALPKPRVK------EEDSED 674
                  DKPLSFRL+   S  S  +   P + G    V S+L   + K        DSED
Sbjct: 127  PDDSDDDKPLSFRLATSGS--SLKIKSQPGTKGHGSPVPSSLQMDKTKITCKKSSADSED 184

Query: 673  EKPLSMKFQLKTNVGTSISNSYDSDENKPIASRLQLNGSGIRGNQVMKSSIALNKRPSAE 494
            E PLS KFQLKTNVG+S+   YDSDE KP+  + Q NGS  + N++ KS  +LNKRP ++
Sbjct: 185  EIPLSSKFQLKTNVGSSV-KKYDSDEEKPLIFKFQQNGSSKKDNELSKSLKSLNKRPMSD 243

Query: 493  AKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMTKDDVDDHVPISQRIKKLATPVSKLSD 314
              +SGQ  VKK KLS++   +  KQ  +K+E   K+D +D++PISQR+KK A   +K S 
Sbjct: 244  VNTSGQSLVKKPKLSES-IPAKVKQAPIKSE--PKEDDEDNIPISQRLKKSAPSDNKSSS 300

Query: 313  KKKTT 299
             KKTT
Sbjct: 301  TKKTT 305



 Score =  124 bits (311), Expect = 1e-26
 Identities = 57/74 (77%), Positives = 62/74 (83%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLY GQPVDLTPEQEEVATM AVM DT+Y  K KF ENFM+DWK ILGKNH+I+ F 
Sbjct: 359 GVKMLYNGQPVDLTPEQEEVATMFAVMKDTEYATKQKFVENFMNDWKVILGKNHVIKKFE 418

Query: 44  DCNFQPIYEWHQRE 3
            C+F PIYEWHQRE
Sbjct: 419 LCDFTPIYEWHQRE 432


>KVH96852.1 DNA breaking-rejoining enzyme, catalytic core [Cynara cardunculus
           var. scolymus]
          Length = 849

 Score =  153 bits (387), Expect = 2e-36
 Identities = 93/212 (43%), Positives = 124/212 (58%)
 Frame = -2

Query: 931 TSAADQSKINSQQTKTTIVKVEKSLGKPXXXXXXXXXXXXXDKPLSFRLSAGASKGSSNV 752
           +S +D+ K ++QQ    +V+ EK   K              DKPLS R+S      S++V
Sbjct: 17  SSTSDKFKHSAQQKAAAVVRQEKPSPKTVAKQNSDSEDSEDDKPLSSRISTVPKANSNHV 76

Query: 751 NKGPDSSGFVSSALPKPRVKEEDSEDEKPLSMKFQLKTNVGTSISNSYDSDENKPIASRL 572
             GP  S   +S   K +VK EDS+DEKPLS KF  K+ V  SI    DSD++KP++S++
Sbjct: 77  KVGPSMS---ASQRSKTQVKNEDSDDEKPLSSKFTPKSYVSASIRKHDDSDDDKPLSSKV 133

Query: 571 QLNGSGIRGNQVMKSSIALNKRPSAEAKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMT 392
           + NGS  R NQ  K +I LNKRP  E  S GQ S+KK KLSD+ A  N K V+VK E  T
Sbjct: 134 KQNGSASRDNQSRKPNIGLNKRPPNEENSLGQSSIKKPKLSDSSAPINRKPVSVKPESET 193

Query: 391 KDDVDDHVPISQRIKKLATPVSKLSDKKKTTV 296
            DD +DHVPISQR+K  A   SK +  K+ ++
Sbjct: 194 DDDENDHVPISQRMKNKAPSGSKSASIKQKSI 225



 Score =  136 bits (342), Expect = 1e-30
 Identities = 60/74 (81%), Positives = 67/74 (90%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLYKG+PVDLTPEQEEVATM AVMLDTDY  KP F+ENFM DW+KILG+NH IQN +
Sbjct: 282 GVKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMTKPVFKENFMGDWRKILGRNHTIQNLD 341

Query: 44  DCNFQPIYEWHQRE 3
           DC+F+PIYEWHQRE
Sbjct: 342 DCDFRPIYEWHQRE 355


>XP_016513485.1 PREDICTED: DNA topoisomerase 1-like [Nicotiana tabacum]
            XP_016513486.1 PREDICTED: DNA topoisomerase 1-like
            [Nicotiana tabacum] XP_016513487.1 PREDICTED: DNA
            topoisomerase 1-like [Nicotiana tabacum]
          Length = 876

 Score =  153 bits (386), Expect = 3e-36
 Identities = 118/309 (38%), Positives = 154/309 (49%), Gaps = 20/309 (6%)
 Frame = -2

Query: 1165 MMNTSDDEDDMPLVFKRSAASKQNQLN-------------------PEVKKSLSQKHDXV 1043
            M    DD+DDMPLVFKRS  SKQNQ N                   P  + S +QK    
Sbjct: 12   MAEVDDDDDDMPLVFKRSTTSKQNQSNSSSQKQDGRSGRQVSDVRSPNGQNSSAQKVKAG 71

Query: 1042 LSTKGXXXXXXXXXXXXXXXXXXXXXXXXXVENTKASTSAADQSKINSQQTKTTIVKVEK 863
             S+K                            N++ S SA +Q+K  +QQ+K  +    K
Sbjct: 72   TSSKASPAVSPFTSPKASPSSSRISPAP----NSRPSASAGNQAKNVNQQSKI-VPNEPK 126

Query: 862  SLGKPXXXXXXXXXXXXXDKPLSFRLSAGASKG-SSNVNKGPDSSGFVSSALPKPRVKEE 686
               +P             DKPLS RLS+G SK  SS+ NK   +S  V  + P    K+E
Sbjct: 127  QAVEPKSGPNDEAEDSEDDKPLSARLSSGLSKSISSHANKVLGTSASVQKSRPP---KKE 183

Query: 685  DSEDEKPLSMKFQLKTNVGTSISNSYDSDENKPIASRLQLNGSGIRGNQVMKSSIALNKR 506
            DS+DE PL+ +FQLK+N G S S S +S+E KP   +++ NG        + S+  L+KR
Sbjct: 184  DSDDEIPLASRFQLKSNAGASTSKSSNSEEVKP---KIRQNG--------LPSTTVLSKR 232

Query: 505  PSAEAKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMTKDDVDDHVPISQRIKKLATPVS 326
            P  + KS+ Q SVKK +LSDA    + KQ +VK E  T+DD DD VPISQRIKK     S
Sbjct: 233  PPGDVKSAAQASVKKLRLSDASTPVSIKQASVKPEKKTEDD-DDDVPISQRIKKSVASAS 291

Query: 325  KLSDKKKTT 299
            K+S  KK T
Sbjct: 292  KVSSTKKAT 300



 Score =  133 bits (335), Expect = 1e-29
 Identities = 57/74 (77%), Positives = 68/74 (91%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLYKG+P++LTPEQEEVATM AVMLDT+Y  KP+F+ENFM+DW+KILGKNH+IQN +
Sbjct: 352 GVKMLYKGKPINLTPEQEEVATMYAVMLDTEYMSKPQFKENFMNDWRKILGKNHVIQNLD 411

Query: 44  DCNFQPIYEWHQRE 3
           DC+F PIYEWHQ E
Sbjct: 412 DCDFTPIYEWHQSE 425


>XP_009619726.2 PREDICTED: DNA topoisomerase 1-like [Nicotiana tomentosiformis]
            XP_018631669.1 PREDICTED: DNA topoisomerase 1-like
            [Nicotiana tomentosiformis]
          Length = 877

 Score =  152 bits (384), Expect = 5e-36
 Identities = 120/310 (38%), Positives = 156/310 (50%), Gaps = 21/310 (6%)
 Frame = -2

Query: 1165 MMNTSDDEDDMPLVFKRSAA-SKQNQLN-------------------PEVKKSLSQKHDX 1046
            M    DD+DDMPLVFKRS+  SKQNQ N                   P  + S +QK   
Sbjct: 12   MAEVDDDDDDMPLVFKRSSTTSKQNQSNSSSQKQDGRSGRQASDVRSPNGQSSSAQKVKA 71

Query: 1045 VLSTKGXXXXXXXXXXXXXXXXXXXXXXXXXVENTKASTSAADQSKINSQQTKTTIVKVE 866
              S+K                            N++ S SA +Q+K  +QQ+K  +    
Sbjct: 72   GTSSKASRAVSPFTSPKASPSSGRTSPAP----NSRPSASAGNQAKDVNQQSKI-VPNEP 126

Query: 865  KSLGKPXXXXXXXXXXXXXDKPLSFRLSAGASKG-SSNVNKGPDSSGFVSSALPKPRVKE 689
            K   +P             DKPLS RLS+G SK  SS+ NK   +S  V  + P    K+
Sbjct: 127  KQAVEPKSEPNDEAEDSEDDKPLSARLSSGLSKSNSSHANKVLGTSASVQKSRPP---KK 183

Query: 688  EDSEDEKPLSMKFQLKTNVGTSISNSYDSDENKPIASRLQLNGSGIRGNQVMKSSIALNK 509
            EDS+DE PL+ +FQLK+N G S S S +S+E KP   +++ NG        + S+  L+K
Sbjct: 184  EDSDDEIPLASRFQLKSNAGASTSKSSNSEEVKP---KIRQNG--------LPSTTVLSK 232

Query: 508  RPSAEAKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMTKDDVDDHVPISQRIKKLATPV 329
            RP  + KS+ Q SVKK +LSDA    +SKQ +VK E  T+DD DD VPISQRIKK     
Sbjct: 233  RPPGDVKSAAQASVKKPRLSDASTPVSSKQASVKPEKKTEDD-DDDVPISQRIKKSVASA 291

Query: 328  SKLSDKKKTT 299
            SKLS  KK T
Sbjct: 292  SKLSSAKKAT 301



 Score =  133 bits (335), Expect = 1e-29
 Identities = 59/74 (79%), Positives = 67/74 (90%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLYKG+PVDLTPEQEEVATM AVMLDTDY  K +F+ENFM+DW+KILGKNH+IQN +
Sbjct: 353 GVKMLYKGKPVDLTPEQEEVATMYAVMLDTDYMSKLQFKENFMNDWRKILGKNHVIQNLD 412

Query: 44  DCNFQPIYEWHQRE 3
           DC+F PIYEWHQ E
Sbjct: 413 DCDFTPIYEWHQSE 426


>XP_016480590.1 PREDICTED: DNA topoisomerase 1-like isoform X2 [Nicotiana tabacum]
          Length = 803

 Score =  151 bits (381), Expect = 1e-35
 Identities = 120/311 (38%), Positives = 156/311 (50%), Gaps = 22/311 (7%)
 Frame = -2

Query: 1165 MMNTSDDEDDMPLVFKRSAA-SKQNQLN-------------------PEVKKSLSQKHDX 1046
            M    DD+DDMPLVFKRS+  SKQNQ N                   P  + S +QK   
Sbjct: 12   MAEVDDDDDDMPLVFKRSSTTSKQNQSNSSSQKQDGRSGRQASDVRSPNGQSSSAQKVKA 71

Query: 1045 VLSTKGXXXXXXXXXXXXXXXXXXXXXXXXXVENTKASTSAADQSKINSQQTKTTIVKVE 866
              S+K                            N++ S SA +Q+K  +QQ+K  +    
Sbjct: 72   GTSSKASRAVSPFTSPKASPSSGRTSPAP----NSRPSASAGNQAKDVNQQSKI-VPNEP 126

Query: 865  KSLGKPXXXXXXXXXXXXXDKPLSFRLSAGASKG-SSNVNKGPDSSGFVSSALPKPRVKE 689
            K   +P             DKPLS RLS+G SK  SS+ NK   +S  V  + P    K+
Sbjct: 127  KQAVEPKSEPNDEAEDSEDDKPLSARLSSGLSKSNSSHANKVLGTSASVQKSRPP---KK 183

Query: 688  EDSEDEKPLSMKFQLKTNVGTSISNSYDSDENKPIASRLQLNGSGIRGNQVMKSSIALNK 509
            EDS+DE PL+ +FQLK+N G S S S +S+E KP   +++ NG        + S+  L+K
Sbjct: 184  EDSDDEIPLASRFQLKSNAGASTSKSSNSEEVKP---KIRQNG--------LPSTTVLSK 232

Query: 508  RPSAEAKSSGQYSVKKAKLSDAPASSNSKQVNVKAELMTK-DDVDDHVPISQRIKKLATP 332
            RP  + KS+ Q SVKK +LSDA    +SKQ +VK E  T+ DD DD VPISQRIKK    
Sbjct: 233  RPPGDVKSAAQASVKKPRLSDASTPVSSKQASVKPEKKTEDDDDDDDVPISQRIKKSVAS 292

Query: 331  VSKLSDKKKTT 299
             SKLS  KK T
Sbjct: 293  ASKLSSAKKAT 303



 Score =  130 bits (327), Expect = 1e-28
 Identities = 58/74 (78%), Positives = 66/74 (89%)
 Frame = -1

Query: 224 GVKMLYKGQPVDLTPEQEEVATMIAVMLDTDYYKKPKFRENFMSDWKKILGKNHIIQNFN 45
           GVKMLYKG+PVDLTPEQEEVATM AVMLDTDY  K +F+ENFM+DW+KILGKNH+IQN +
Sbjct: 355 GVKMLYKGKPVDLTPEQEEVATMYAVMLDTDYMSKLQFKENFMNDWRKILGKNHVIQNLD 414

Query: 44  DCNFQPIYEWHQRE 3
           DC+F  IYEWHQ E
Sbjct: 415 DCDFTQIYEWHQSE 428