BLASTX 2.2.26 [Sep-21-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Ophiopogon26_contig00042526
         (2163 letters)

Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects 
           149,584,005 sequences; 54,822,741,787 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gb|POG69495.1| neutral ceramidase-like protein [Rhizophagus irre...  1380   0.0  
gb|PKY43755.1| neutral ceramidase-like protein [Rhizophagus irre...  1367   0.0  
dbj|GBC14434.1| Neutral/alkaline nonlysosomal ceramidase [Rhizop...  1367   0.0  
gb|PKC57179.1| neutral ceramidase-like protein [Rhizophagus irre...  1363   0.0  
gb|ORX89074.1| Neutral/alkaline nonlysosomal ceramidase [Basidio...   673   0.0  
gb|ORX82000.1| Neutral/alkaline nonlysosomal ceramidase [Basidio...   671   0.0  
ref|XP_022319136.1| neutral ceramidase-like [Crassostrea virginica]   632   0.0  
ref|XP_011454842.1| PREDICTED: neutral ceramidase [Crassostrea g...   630   0.0  
ref|XP_019620213.1| PREDICTED: neutral ceramidase-like isoform X...   627   0.0  
ref|XP_022319861.1| neutral ceramidase-like [Crassostrea virginica]   627   0.0  
ref|XP_013094566.1| PREDICTED: neutral ceramidase-like isoform X...   616   0.0  
ref|XP_014680017.1| PREDICTED: neutral ceramidase-like [Priapulu...   615   0.0  
ref|XP_023932283.1| neutral ceramidase isoform X1 [Lingula anatina]   612   0.0  
ref|XP_013402701.1| neutral ceramidase isoform X2 [Lingula anatina]   610   0.0  
ref|XP_013402699.1| neutral ceramidase [Lingula anatina]              611   0.0  
ref|XP_019620212.1| PREDICTED: neutral ceramidase-like isoform X...   608   0.0  
ref|XP_005100690.1| PREDICTED: neutral ceramidase-like [Aplysia ...   603   0.0  
gb|KVI11923.1| Neutral/alkaline nonlysosomal ceramidase [Cynara ...   603   0.0  
ref|XP_647372.1| neutral/alkaline nonlysosomal ceramidase family...   596   0.0  
ref|XP_013094635.1| PREDICTED: neutral ceramidase-like isoform X...   589   0.0  

>gb|POG69495.1| neutral ceramidase-like protein [Rhizophagus irregularis DAOM
            181602=DAOM 197198]
          Length = 699

 Score = 1380 bits (3573), Expect = 0.0
 Identities = 678/689 (98%), Positives = 682/689 (98%)
 Frame = +3

Query: 3    YILYILLMVTTQLNQNLVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIR 182
            YILYILLMVTTQLNQNLVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIR
Sbjct: 7    YILYILLMVTTQLNQNLVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIR 66

Query: 183  QRSRAFIIIDPDTGKRVVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTH 362
            QRSRAFIIIDPDTGKRVVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTH
Sbjct: 67   QRSRAFIIIDPDTGKRVVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTH 126

Query: 363  AGPAGYLQYALYQITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNIN 542
            AGPAGYLQYALYQITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNIN
Sbjct: 127  AGPAGYLQYALYQITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNIN 186

Query: 543  RSPFSYEQNPEEERSQYKYNVDKEMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSG 722
            RSPFSYEQNPEEERSQYKYNVDKEMILLKFTN KGDVIGSINWFPVHPVSMMNNNTLVSG
Sbjct: 187  RSPFSYEQNPEEERSQYKYNVDKEMILLKFTNAKGDVIGSINWFPVHPVSMMNNNTLVSG 246

Query: 723  DNKGTASYFLEREYNNGTLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTC 902
            DNKGTASYFLEREYNN TLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTC
Sbjct: 247  DNKGTASYFLEREYNNSTLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTC 306

Query: 903  NGKKETCFGRGYGYLTGDDIYATRKIAELHVTKAKELIDTAKTPITGSIDYKFTKVDIQN 1082
            NGKKETCFGRGYGYLTGDDIYATRKIAELHV KAKELIDTAKTPITGSIDYKFTKV+IQN
Sbjct: 307  NGKKETCFGRGYGYLTGDDIYATRKIAELHVAKAKELIDTAKTPITGSIDYKFTKVNIQN 366

Query: 1083 YNFTLNGKTVSLCKAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKET 1262
            YNFTLNGKTVSLCKAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKET
Sbjct: 367  YNFTLNGKTVSLCKAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKET 426

Query: 1263 IECQRPKPIVLATGEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKN 1442
            IECQRPKPIVLATGEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKN
Sbjct: 427  IECQRPKPIVLATGEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKN 486

Query: 1443 ILMKKGVIDENGIVVVSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDL 1622
            ILMKKGVIDENGIV+VSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDL
Sbjct: 487  ILMKKGVIDENGIVIVSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDL 546

Query: 1623 SIALADNLYVPIGPEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEV 1802
            SIALADNLYVPIGPEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETV V
Sbjct: 547  SIALADNLYVPIGPEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVAV 606

Query: 1803 EFVGGHPKNRIQLEGSFLYVQRLENNNNWINFKNDGDITTQFKWLGNSIVRITWEIGDDV 1982
            EFVGGHPKN IQLEGSFLYVQRLENNNNW+NFKNDGDITT+FKWLGNSIVRITWEI DDV
Sbjct: 607  EFVGGHPKNHIQLEGSFLYVQRLENNNNWVNFKNDGDITTKFKWLGNSIVRITWEIDDDV 666

Query: 1983 EAGTYRIFYQGHHKQLGGKIVPEFGTTSN 2069
            EAGTYRIFYQGHHKQLGGKIVPEFG TSN
Sbjct: 667  EAGTYRIFYQGHHKQLGGKIVPEFGITSN 695


>gb|PKY43755.1| neutral ceramidase-like protein [Rhizophagus irregularis]
          Length = 686

 Score = 1367 bits (3539), Expect = 0.0
 Identities = 671/682 (98%), Positives = 675/682 (98%)
 Frame = +3

Query: 24   MVTTQLNQNLVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFI 203
            MVTTQLNQNLVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFI
Sbjct: 1    MVTTQLNQNLVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFI 60

Query: 204  IIDPDTGKRVVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYL 383
            IIDPDTGKRVVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYL
Sbjct: 61   IIDPDTGKRVVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYL 120

Query: 384  QYALYQITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYE 563
            QYALYQITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYE
Sbjct: 121  QYALYQITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYE 180

Query: 564  QNPEEERSQYKYNVDKEMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTAS 743
            QNPEEERSQYKYNVDKEMILLKFTN KGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTAS
Sbjct: 181  QNPEEERSQYKYNVDKEMILLKFTNAKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTAS 240

Query: 744  YFLEREYNNGTLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETC 923
            YFLEREYNN TLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETC
Sbjct: 241  YFLEREYNNSTLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETC 300

Query: 924  FGRGYGYLTGDDIYATRKIAELHVTKAKELIDTAKTPITGSIDYKFTKVDIQNYNFTLNG 1103
            FGRGYGYLTGDDIYATRKIAELHV KAKELIDTAKTPITGSIDYKFTKV+IQNYNFTLNG
Sbjct: 301  FGRGYGYLTGDDIYATRKIAELHVAKAKELIDTAKTPITGSIDYKFTKVNIQNYNFTLNG 360

Query: 1104 KTVSLCKAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPK 1283
            KTVSLCKAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPK
Sbjct: 361  KTVSLCKAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPK 420

Query: 1284 PIVLATGEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGV 1463
            PIVLATGEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGV
Sbjct: 421  PIVLATGEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGV 480

Query: 1464 IDENGIVVVSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADN 1643
            IDENGIV+VSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADN
Sbjct: 481  IDENGIVIVSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADN 540

Query: 1644 LYVPIGPEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEVEFVGGHP 1823
            LYVPIGPEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETV VEFVGGHP
Sbjct: 541  LYVPIGPEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVTVEFVGGHP 600

Query: 1824 KNRIQLEGSFLYVQRLENNNNWINFKNDGDITTQFKWLGNSIVRITWEIGDDVEAGTYRI 2003
            KN IQLEGSFLYVQRLENNNNW+NFKNDGDITT+FKWLGNSIVRITWEI DDVEAGTYRI
Sbjct: 601  KNHIQLEGSFLYVQRLENNNNWVNFKNDGDITTKFKWLGNSIVRITWEIDDDVEAGTYRI 660

Query: 2004 FYQGHHKQLGGKIVPEFGTTSN 2069
            FYQGHHKQLGGKIVPEFG TSN
Sbjct: 661  FYQGHHKQLGGKIVPEFGITSN 682


>dbj|GBC14434.1| Neutral/alkaline nonlysosomal ceramidase [Rhizophagus irregularis
            DAOM 181602]
 gb|PKC06905.1| neutral ceramidase-like protein [Rhizophagus irregularis]
 gb|PKK68696.1| neutral ceramidase-like protein [Rhizophagus irregularis]
 gb|PKY31427.1| neutral ceramidase-like protein [Rhizophagus irregularis]
          Length = 686

 Score = 1367 bits (3539), Expect = 0.0
 Identities = 671/682 (98%), Positives = 675/682 (98%)
 Frame = +3

Query: 24   MVTTQLNQNLVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFI 203
            MVTTQLNQNLVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFI
Sbjct: 1    MVTTQLNQNLVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFI 60

Query: 204  IIDPDTGKRVVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYL 383
            IIDPDTGKRVVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYL
Sbjct: 61   IIDPDTGKRVVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYL 120

Query: 384  QYALYQITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYE 563
            QYALYQITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYE
Sbjct: 121  QYALYQITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYE 180

Query: 564  QNPEEERSQYKYNVDKEMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTAS 743
            QNPEEERSQYKYNVDKEMILLKFTN KGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTAS
Sbjct: 181  QNPEEERSQYKYNVDKEMILLKFTNAKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTAS 240

Query: 744  YFLEREYNNGTLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETC 923
            YFLEREYNN TLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETC
Sbjct: 241  YFLEREYNNSTLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETC 300

Query: 924  FGRGYGYLTGDDIYATRKIAELHVTKAKELIDTAKTPITGSIDYKFTKVDIQNYNFTLNG 1103
            FGRGYGYLTGDDIYATRKIAELHV KAKELIDTAKTPITGSIDYKFTKV+IQNYNFTLNG
Sbjct: 301  FGRGYGYLTGDDIYATRKIAELHVAKAKELIDTAKTPITGSIDYKFTKVNIQNYNFTLNG 360

Query: 1104 KTVSLCKAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPK 1283
            KTVSLCKAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPK
Sbjct: 361  KTVSLCKAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPK 420

Query: 1284 PIVLATGEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGV 1463
            PIVLATGEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGV
Sbjct: 421  PIVLATGEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGV 480

Query: 1464 IDENGIVVVSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADN 1643
            IDENGIV+VSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADN
Sbjct: 481  IDENGIVIVSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADN 540

Query: 1644 LYVPIGPEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEVEFVGGHP 1823
            LYVPIGPEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETV VEFVGGHP
Sbjct: 541  LYVPIGPEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVAVEFVGGHP 600

Query: 1824 KNRIQLEGSFLYVQRLENNNNWINFKNDGDITTQFKWLGNSIVRITWEIGDDVEAGTYRI 2003
            KN IQLEGSFLYVQRLENNNNW+NFKNDGDITT+FKWLGNSIVRITWEI DDVEAGTYRI
Sbjct: 601  KNHIQLEGSFLYVQRLENNNNWVNFKNDGDITTKFKWLGNSIVRITWEIDDDVEAGTYRI 660

Query: 2004 FYQGHHKQLGGKIVPEFGTTSN 2069
            FYQGHHKQLGGKIVPEFG TSN
Sbjct: 661  FYQGHHKQLGGKIVPEFGITSN 682


>gb|PKC57179.1| neutral ceramidase-like protein [Rhizophagus irregularis]
          Length = 686

 Score = 1363 bits (3529), Expect = 0.0
 Identities = 670/682 (98%), Positives = 674/682 (98%)
 Frame = +3

Query: 24   MVTTQLNQNLVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFI 203
            MVTTQLNQNLVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFI
Sbjct: 1    MVTTQLNQNLVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFI 60

Query: 204  IIDPDTGKRVVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYL 383
            IIDPDTGKRVVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYL
Sbjct: 61   IIDPDTGKRVVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYL 120

Query: 384  QYALYQITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYE 563
            QYALYQITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYE
Sbjct: 121  QYALYQITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYE 180

Query: 564  QNPEEERSQYKYNVDKEMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTAS 743
            QNPEEERSQYKYNVDKEMILLKFTN KGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTAS
Sbjct: 181  QNPEEERSQYKYNVDKEMILLKFTNAKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTAS 240

Query: 744  YFLEREYNNGTLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETC 923
            YFLEREYNN TLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETC
Sbjct: 241  YFLEREYNNSTLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETC 300

Query: 924  FGRGYGYLTGDDIYATRKIAELHVTKAKELIDTAKTPITGSIDYKFTKVDIQNYNFTLNG 1103
            FGRGYGYLTGDDIYATRKIAELHV KAKELIDTAKTPITGSIDYKFTKV+IQNYNFTLNG
Sbjct: 301  FGRGYGYLTGDDIYATRKIAELHVAKAKELIDTAKTPITGSIDYKFTKVNIQNYNFTLNG 360

Query: 1104 KTVSLCKAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPK 1283
            KTVSLCKAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIE QRPK
Sbjct: 361  KTVSLCKAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIELQRPK 420

Query: 1284 PIVLATGEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGV 1463
            PIVLATGEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGV
Sbjct: 421  PIVLATGEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGV 480

Query: 1464 IDENGIVVVSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADN 1643
            IDENGIV+VSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADN
Sbjct: 481  IDENGIVIVSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADN 540

Query: 1644 LYVPIGPEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEVEFVGGHP 1823
            LYVPIGPEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETV VEFVGGHP
Sbjct: 541  LYVPIGPEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVAVEFVGGHP 600

Query: 1824 KNRIQLEGSFLYVQRLENNNNWINFKNDGDITTQFKWLGNSIVRITWEIGDDVEAGTYRI 2003
            KN IQLEGSFLYVQRLENNNNW+NFKNDGDITT+FKWLGNSIVRITWEI DDVEAGTYRI
Sbjct: 601  KNHIQLEGSFLYVQRLENNNNWVNFKNDGDITTKFKWLGNSIVRITWEIDDDVEAGTYRI 660

Query: 2004 FYQGHHKQLGGKIVPEFGTTSN 2069
            FYQGHHKQLGGKIVPEFG TSN
Sbjct: 661  FYQGHHKQLGGKIVPEFGITSN 682


>gb|ORX89074.1| Neutral/alkaline nonlysosomal ceramidase [Basidiobolus meristosporus
            CBS 931.73]
          Length = 693

 Score =  673 bits (1737), Expect = 0.0
 Identities = 335/671 (49%), Positives = 455/671 (67%), Gaps = 7/671 (1%)
 Frame = +3

Query: 75   NYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFIIIDPD-TGKRVVFVSAD 251
            +Y +G+GIADITG  A +NMMGYA   Q  +G+H+R RSRAFI+ DP+ T  R+ +VSAD
Sbjct: 20   DYMIGVGIADITGPAAEINMMGYAKASQKTAGIHLRLRSRAFIVSDPNATENRIAYVSAD 79

Query: 252  LAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYLQYALYQITSFGYFKEN 431
            L M S  VRR  +E LK+ +GDLYND NVA++GTHTH+GP G+ QY LYQ T+ G+ ++ 
Sbjct: 80   LGMISQVVRRRVIEALKQLYGDLYNDNNVALTGTHTHSGPGGWHQYVLYQFTNLGFIEDA 139

Query: 432  TEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYEQNPEEERSQYKYNVDK 611
            T  +  GI NSI +AH ++ P  I  S G++ N NINRSP++Y+QNP+ ER++YK+N D+
Sbjct: 140  TRPVVNGIVNSIQRAHENMTPGFITTSAGDVENGNINRSPWAYDQNPQSERARYKHNTDQ 199

Query: 612  EMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTASYFLEREYN-NGTLPGE 788
            EM L+KFTNE G+ +G +NW+ VH  SM N N L+SGDNKG A+Y  ERE N +  LPG 
Sbjct: 200  EMRLVKFTNEAGEPLGILNWYAVHCTSMNNENLLISGDNKGYAAYAFEREMNGDDILPGT 259

Query: 789  ETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETCFGRGYGYLTGDDIYA 968
               +  FA SN+GD SPN  GP C D+GLPC+Y+TSTCNGK E C  RG GY TG D+ +
Sbjct: 260  GKFVAGFAQSNMGDVSPNTQGPRCLDSGLPCDYKTSTCNGKNELCVARGPGYETGGDVES 319

Query: 969  TRKIAELHVTKAKELIDTAKTPITGSIDYKFTKVDIQNYNFTL-NGKTVSLCKAALGYSM 1145
            TR I       AK L++ AK  + G +D++   VD+      L N  T  LCK A+GYS 
Sbjct: 320  TRIIGSYQYETAKRLMNEAKEYVKGPVDFRHQFVDLTKVEVKLGNSTTKRLCKPAMGYSF 379

Query: 1146 IAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPKPIVLATGEMRSPYD 1325
             AGTTDGPG F+F QGD++  +PFW ++   I +P++E  ECQ PKP++LATGE++ PY 
Sbjct: 380  AAGTTDGPGEFDFTQGDSNVSHPFWDVVRAFITKPSEELKECQSPKPVLLATGEIKLPYM 439

Query: 1326 FTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGVIDENGIVVVSGPSN 1505
            + P +++IQ+L++G  +I VVPGEFTTMSGRRL + +  +  +   + +N IVV++GPSN
Sbjct: 440  WQPRVVDIQILRVGQLVIAVVPGEFTTMSGRRLREAIGQVFAETSDL-KNPIVVLAGPSN 498

Query: 1506 SYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADNLYVPIGPEAPDFTD 1685
            +Y+ Y+TTPEEY  QRYEG STIYGPNTL+ Y+QLY +++ A+     V      PD T 
Sbjct: 499  TYSSYVTTPEEYSAQRYEGASTIYGPNTLDGYIQLYKEVAAAMIQGKPVVSLISTPDLTR 558

Query: 1686 KALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEVEFVGGHPKNRIQLEGSFLYVQ 1865
             A+N    V++D  P+ KKFGDV KDA   Y  G+TV V FVGGHPKN++ LE +FL V+
Sbjct: 559  NAINLQTGVVLDTAPIGKKFGDVLKDAQATYKIGDTVSVAFVGGHPKNKVALEETFLTVE 618

Query: 1866 RLENNNNWINFKNDGDITTQFKW----LGNSIVRITWEIGDDVEAGTYRIFYQGHHKQLG 2033
             ++ +++W   +NDGD  T+F+W    +  S V I W+I  +V+ G YRI Y G +K   
Sbjct: 619  -MQTSDDWKVVRNDGDWCTKFQWKRQGIAESNVTIQWQIEPNVKPGIYRIGYFGANKAF- 676

Query: 2034 GKIVPEFGTTS 2066
            GKI    G +S
Sbjct: 677  GKISSHSGYSS 687


>gb|ORX82000.1| Neutral/alkaline nonlysosomal ceramidase [Basidiobolus meristosporus
            CBS 931.73]
          Length = 692

 Score =  671 bits (1732), Expect = 0.0
 Identities = 346/680 (50%), Positives = 455/680 (66%), Gaps = 12/680 (1%)
 Frame = +3

Query: 60   GQSVTNYNVGIGIADITGI------VAGVNMMGYAMPGQIASGLHIRQRSRAFIIIDPDT 221
            G       +G GIADITG       VA VNMMGYA   Q ++G+H R RSRAFII D + 
Sbjct: 13   GSPFLQLKIGAGIADITGYAFYLFHVAEVNMMGYAKSSQKSAGIHFRLRSRAFIIGDQNA 72

Query: 222  G-KRVVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYLQYALY 398
              KRVV+VSAD+ M S  +RR  + KLK  +G+LYND+NVA++GTHTH+GP G+ QY LY
Sbjct: 73   SDKRVVYVSADIGMISQVIRRRVVAKLKTLYGNLYNDDNVALTGTHTHSGPGGWHQYVLY 132

Query: 399  QITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYEQNPEE 578
            Q T+ G+ +E T  +  GI NSI KAH S+ P SI  S+G++ N NINRSP++YEQNPE 
Sbjct: 133  QFTNLGFIEEATRPVVDGIVNSIKKAHESMVPGSITTSSGDVENGNINRSPWAYEQNPES 192

Query: 579  ERSQYKYNVDKEMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTASYFLER 758
            ER++YK+N D  M L+KFT+E G  IG +NW+ VH  SM ++N L+SGDNKG ASY  E+
Sbjct: 193  ERARYKHNTDTNMRLIKFTDESGKPIGILNWYAVHCTSMNSDNLLISGDNKGYASYLFEK 252

Query: 759  EYNNGTLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETCFGRGY 938
            E N  TLPG    +  FA SN+GD SPN  GP C DTGLPC+Y+TSTC+GK       G 
Sbjct: 253  EMNENTLPGTGKFVAGFAQSNMGDVSPNTQGPRCLDTGLPCDYKTSTCDGKN----ALGP 308

Query: 939  GYLTGDDIYATRKIAELHVTKAKELIDTAKTPITGSIDYKFTKVDIQNYNFTLNG-KTVS 1115
            GY TG D+ +TR I       A++L++ A   I GSID++   VD+      LN   TV+
Sbjct: 309  GYETGGDVESTRIIGSYQYQTARKLMNEATNAIKGSIDFRHQFVDMTGVQVKLNATTTVN 368

Query: 1116 LCKAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPKPIVL 1295
            LCK A+GYS  AGTTDGPG F+F QGD+   +PFW ++   I  P+KE   C  PKPI+L
Sbjct: 369  LCKPAMGYSFAAGTTDGPGEFDFKQGDSDKKHPFWDVVRAFITTPSKELEACHSPKPILL 428

Query: 1296 ATGEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGVIDEN 1475
            ATGE++ PY + P +++IQ+L+IG  +I VVPGEFTTMSGRRL + +  + ++   I ++
Sbjct: 429  ATGEIKLPYMWQPKVVDIQILRIGQLVIAVVPGEFTTMSGRRLREAIAKVFLETSDI-KD 487

Query: 1476 GIVVVSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADNLYVP 1655
             IVV++GPSN+Y+ YI TPEEY VQRYEGGSTIYGPNTL  Y+QLY++++ A+  N    
Sbjct: 488  PIVVLAGPSNTYSSYIATPEEYSVQRYEGGSTIYGPNTLPGYIQLYSEMAAAMIQNKPTV 547

Query: 1656 IGPEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEVEFVGGHPKNRI 1835
               + PD T  A+N    V++D  P+ KKFG+V KDAN  Y  G TV V FVGGHPKN+I
Sbjct: 548  SLTQPPDLTPGAINLQTGVVLDTAPIGKKFGNVLKDANDSYKPGNTVSVTFVGGHPKNKI 607

Query: 1836 QLEGSFLYVQRLENNNNWINFKNDGDITTQFKW----LGNSIVRITWEIGDDVEAGTYRI 2003
             LE +FL V+ +++++ W   KNDGD +T+F+W    +  S+V I W+I  D + G+YRI
Sbjct: 608  TLEDTFLTVE-MQSSDGWKTVKNDGDWSTKFQWARQGVSESLVTIEWQIEPDTKPGSYRI 666

Query: 2004 FYQGHHKQLGGKIVPEFGTT 2063
             Y G +K   GKI P  G T
Sbjct: 667  GYFGANKAF-GKITPHSGYT 685


>ref|XP_022319136.1| neutral ceramidase-like [Crassostrea virginica]
          Length = 740

 Score =  632 bits (1629), Expect = 0.0
 Identities = 330/678 (48%), Positives = 436/678 (64%), Gaps = 8/678 (1%)
 Frame = +3

Query: 57   HGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFIIIDPDTGKRVV 236
            HGQ+ TNY +G GIADITG  A V+MMGYA P Q + G+H+RQ SRAF+I D     R+V
Sbjct: 21   HGQT-TNYIIGAGIADITGPAAEVDMMGYANPAQTSKGIHLRQYSRAFVIADAANKSRIV 79

Query: 237  FVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYLQYALYQITSFG 416
            FVS D  M S  ++   +++L+  +GDLYN+ NVAISGTHTH+GP G+ QY LY +TS G
Sbjct: 80   FVSTDSCMQSQGLKLEIIKRLRSKYGDLYNERNVAISGTHTHSGPGGFHQYLLYDVTSLG 139

Query: 417  YFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYEQNPEEERSQYK 596
            +  E   ++  GI  SI KAHNS++P +++V+TGELL++NINRSP +Y  NP EER++YK
Sbjct: 140  FVNETFVSLVEGIVASIDKAHNSMKPGNLYVNTGELLDSNINRSPTAYLNNPAEERAKYK 199

Query: 597  YNVDKEMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTASYFLEREYNNGT 776
            Y+VDK M +L+ T+ + + IG INWF VH  SM N N L+S DNKG A+   E + N G 
Sbjct: 200  YDVDKNMTVLRMTDAQNNGIGMINWFAVHCTSMNNTNHLISSDNKGLAAQMFEADMNKGG 259

Query: 777  LPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETCFGRGYGYLTGD 956
             PG+   + AFA SN GD SPN  GP+C DTG PC+  TSTCNG+ E C   G G    D
Sbjct: 260  FPGKGKFVAAFAQSNEGDVSPNTKGPHCMDTGKPCDVPTSTCNGRNELCVSPGPG---KD 316

Query: 957  DIYATRKIAELHVTKAKELI-DTAKTPITGSIDYKFTKVDIQNYNFTLNGKT-VSLCKAA 1130
               +TR IA     KAK L  D A   + G +D++ T VD+ +    +N  T V  CK A
Sbjct: 317  MFDSTRIIASNQYKKAKILYSDPAGMKLEGPVDFRHTYVDMSSVMVQINQTTKVKTCKPA 376

Query: 1131 LGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPKPIVLATGEM 1310
            +G+S  AGTTDGPG FNF QGD +T NPFW  I   +K+PT E + CQ PKPI+L TGEM
Sbjct: 377  MGFSFAAGTTDGPGAFNFTQGD-TTDNPFWDFIRDFLKKPTPEQLACQHPKPILLDTGEM 435

Query: 1311 RSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGVIDENGIVVV 1490
             +PY ++PSI+++Q+ +IG   I  VP EF+TMSGRR T+      +K G    N + V+
Sbjct: 436  TAPYAWSPSIVDLQIFRIGQLAIISVPAEFSTMSGRR-TRDSITATLKAGGFPANTVSVI 494

Query: 1491 SGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADNLYVPIGPEA 1670
            +G +N Y  Y+TT EEY VQRYEG STIYGP+TL A++Q +  L+ ALA     P GP  
Sbjct: 495  AGLTNDYADYVTTYEEYQVQRYEGASTIYGPHTLQAFIQEFNKLADALAKGTPSPKGPTP 554

Query: 1671 PDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEVEFVGGHPKNRIQLEGS 1850
            P+  DK L+F+ PV+ D  P   KFGDV  DAN +Y +G++V+V F+G +P+N ++LE +
Sbjct: 555  PNLLDKQLSFLPPVVFDHAPFGSKFGDVVVDANSQYKQGDSVKVTFIGANPRNNVKLEDT 614

Query: 1851 FLYVQRLENNNNWINFKNDGDITTQFKW------LGNSIVRITWEIGDDVEAGTYRIFYQ 2012
            FL V+ L+ +NNW     D    T+F+W      LG S V ITW+I      GTYRI Y 
Sbjct: 615  FLSVEMLQPDNNWKVVFTDSQWETKFEWKHTSLLLGESEVTITWDIPQSQAPGTYRIQYF 674

Query: 2013 GHHKQLGGKIVPEFGTTS 2066
            G  K L  KI    G ++
Sbjct: 675  GDAKSLDQKITSFTGKST 692


>ref|XP_011454842.1| PREDICTED: neutral ceramidase [Crassostrea gigas]
 gb|EKC40757.1| Neutral ceramidase B [Crassostrea gigas]
          Length = 740

 Score =  630 bits (1626), Expect = 0.0
 Identities = 329/673 (48%), Positives = 433/673 (64%), Gaps = 9/673 (1%)
 Frame = +3

Query: 51   LVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFIIIDPDTGKR 230
            + +GQ+ TNY +G GIADITG  A V+MMGYA P Q + G+H+RQ SRAFII D     R
Sbjct: 19   ICNGQN-TNYIIGAGIADITGPAAEVDMMGYANPAQTSKGIHLRQYSRAFIITDSANKSR 77

Query: 231  VVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYLQYALYQITS 410
            +VFVS D  M S  ++   +++LK  +GDLYN+ NVAISGTHTH+GP G+ QY LY ITS
Sbjct: 78   IVFVSTDSCMQSQGLKLEIIKRLKSKYGDLYNERNVAISGTHTHSGPGGFHQYLLYDITS 137

Query: 411  FGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYEQNPEEERSQ 590
             G+  E    +  GI  SI KAHNS++P +++V+TGELL +NINRSP +Y  NP EER++
Sbjct: 138  LGFVNETFVPLVEGIVASIDKAHNSMKPGNLYVNTGELLESNINRSPTAYLNNPAEERAK 197

Query: 591  YKYNVDKEMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTASYFLEREYNN 770
            YKYNVDK M +L+ T+ + + IG INWF VH  SM N N L+S DNKG A+   E + N 
Sbjct: 198  YKYNVDKNMTVLRLTDAQNNGIGMINWFAVHCTSMNNTNHLISSDNKGLAAQMFEADMNK 257

Query: 771  GTLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETCFGRGYGYLT 950
            G  PG+   + AFA SN GD SPN  GP+C DTG PC+  TSTCNG+ E C   G     
Sbjct: 258  GAFPGKGKFVAAFAQSNEGDVSPNTKGPHCMDTGKPCDVPTSTCNGRNELCVSPG----P 313

Query: 951  GDDIY-ATRKIAELHVTKAKELI-DTAKTPITGSIDYKFTKVDIQNYNFTLNGKT-VSLC 1121
            G D+Y +TR IA+    KAK L  D +   + G +D++ T VD+ N    +N  T V  C
Sbjct: 314  GKDMYDSTRIIAKNQYQKAKILYNDPSNMKLEGPVDFRHTYVDMSNVMVQINQTTKVKTC 373

Query: 1122 KAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPKPIVLAT 1301
            K A+G+S  AGTTDGPG FNF QGD +T NPFW  +   +K+P+ E + CQ PKPI+L T
Sbjct: 374  KPAMGFSFAAGTTDGPGAFNFTQGD-TTDNPFWDFVRDFLKKPSPEQLACQHPKPILLDT 432

Query: 1302 GEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGVIDENGI 1481
            GEM  PY ++PSI+++Q+ +IG   I  VP EF+TMSGRR   ++   L   G    N +
Sbjct: 433  GEMTVPYAWSPSIVDLQIFRIGQLAIISVPAEFSTMSGRRTRDSITATLKAAG-FPANTV 491

Query: 1482 VVVSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADNLYVPIG 1661
             V++G +N Y  Y+TT EEY +QRYEG STIYGP+TL A++Q +  L+ ALA     P G
Sbjct: 492  SVIAGLTNDYADYVTTYEEYQIQRYEGASTIYGPHTLEAFIQEFNKLADALAKGTPAPKG 551

Query: 1662 PEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEVEFVGGHPKNRIQL 1841
            P  P+  DK L+F+ PV+ D  P  K FGDV  DA+ +Y +G +V+V F+G +P+N ++L
Sbjct: 552  PTPPNLLDKQLSFLPPVVFDHAPFGKSFGDVVVDADVQYKQGSSVKVTFIGANPRNNVKL 611

Query: 1842 EGSFLYVQRLENNNNWINFKNDGDITTQFKW------LGNSIVRITWEIGDDVEAGTYRI 2003
            EG+FL V+ L+ +NNW     D    T+F+W      LG S V ITW+I      GTYRI
Sbjct: 612  EGTFLSVEMLQPDNNWKVVFTDSQWETKFEWKHTSLLLGESEVTITWDIPQTQALGTYRI 671

Query: 2004 FYQGHHKQLGGKI 2042
             Y G  K L  KI
Sbjct: 672  QYFGDAKSLDQKI 684


>ref|XP_019620213.1| PREDICTED: neutral ceramidase-like isoform X2 [Branchiostoma
            belcheri]
          Length = 717

 Score =  627 bits (1617), Expect = 0.0
 Identities = 322/671 (47%), Positives = 430/671 (64%), Gaps = 8/671 (1%)
 Frame = +3

Query: 75   NYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFIIIDPDTGKRVVFVSADL 254
            NY VG+G AD+TG  A VNMMGYA P Q +SG+H RQ SRAFI+ DP    R VFVS D 
Sbjct: 45   NYLVGVGRADVTGPAAEVNMMGYANPAQQSSGIHFRQFSRAFIVSDPQNTTRTVFVSVDC 104

Query: 255  AMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYLQYALYQITSFGYFKENT 434
            AM S  ++   ++KLK  FG+ YN+ NV +S  HTH+GPAG+LQY L+ +TS G+ +E+ 
Sbjct: 105  AMVSQILKIEVVKKLKPLFGNAYNESNVCLSAIHTHSGPAGFLQYVLFDVTSLGFVRESF 164

Query: 435  EAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYEQNPEEERSQYKYNVDKE 614
             A+  GI  SI +AHN++ P  ++++ GEL + NINRSP +Y  NPE ER++Y  N DK 
Sbjct: 165  NALVDGIVASIQRAHNNVVPGDLYLNQGELQDANINRSPTAYLNNPESERAKYDANTDKN 224

Query: 615  MILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTASYFLEREYNNGTLPGEET 794
            M++LKF ++ G  +G I+WF VH  SM N N L+SGDNKG AS   E + N G+L G+ +
Sbjct: 225  MVVLKFVDQHGTGLGMISWFAVHCTSMNNTNGLISGDNKGYASQLFEADMNPGSLAGQGS 284

Query: 795  IIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETCFGRGYGYLTGDDIYATR 974
             + AFA SN GD SPN  GP+C DTGL C+  TSTCNGK E C   G G    D   +TR
Sbjct: 285  FVAAFAQSNEGDVSPNTRGPHCQDTGLACDLETSTCNGKSELCVSPGPGV---DMFDSTR 341

Query: 975  KIAELHVTKAKELIDT-AKTPITGSIDYKFTKVDIQNYNFTLNGK-TVSLCKAALGYSMI 1148
             I     +KAKEL +  A+  ++G + +    VD+ +    +N   +   CK A+GYS  
Sbjct: 342  IIGHKQYSKAKELYNADAQEKLSGPVQFALQFVDMSDVTVQINSSYSAKTCKPAMGYSFA 401

Query: 1149 AGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPKPIVLATGEMRSPYDF 1328
            AGTTDGPG F+F QGD + GNPFW  +  IIKQP+ E + CQ PKPI+L TGEM  PY +
Sbjct: 402  AGTTDGPGAFDFTQGD-TEGNPFWNFVRNIIKQPSAEEVACQAPKPILLPTGEMTFPYAW 460

Query: 1329 TPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGVIDENGIVVVSGPSNS 1508
             P I++IQLL+ G  ++  VPGEF+TMSGRRL  +++  ++ KG + E+  VVV+G SN+
Sbjct: 461  QPDIVDIQLLRWGQLVVAAVPGEFSTMSGRRLRDSIQRAVVSKG-LPEDTEVVVAGLSNT 519

Query: 1509 YTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADNLYVPIGPEAPDFTDK 1688
            Y+ YITT EEY VQRYEG STIYGP+TL AY QLY+ L+  +     + IGP  P+   +
Sbjct: 520  YSDYITTYEEYQVQRYEGASTIYGPHTLAAYQQLYSQLAQDMVMGADIDIGPSPPNLLSR 579

Query: 1689 ALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEVEFVGGHPKNRIQLEGSFLYVQR 1868
             L+F+ PV++D  PLF  FG+V  DA   Y   ETV V F   HP+N +QL+GSFL V+R
Sbjct: 580  QLSFLPPVVLDTTPLFTHFGEVITDAGSAYHTNETVSVRFHSAHPRNNLQLDGSFLTVER 639

Query: 1869 LENNNNWINFKNDGDITTQFKW------LGNSIVRITWEIGDDVEAGTYRIFYQGHHKQL 2030
             +++  +    ND    T +KW      +G+S   ITW I      GTYRI + GH K L
Sbjct: 640  KKDDGTFEVVHNDASWDTMYKWKRTNVLVGHSEATITWTISPGTPPGTYRIRHFGHSKNL 699

Query: 2031 GGKIVPEFGTT 2063
             G+I P  G++
Sbjct: 700  VGEITPFVGSS 710


>ref|XP_022319861.1| neutral ceramidase-like [Crassostrea virginica]
          Length = 740

 Score =  627 bits (1616), Expect = 0.0
 Identities = 328/678 (48%), Positives = 433/678 (63%), Gaps = 8/678 (1%)
 Frame = +3

Query: 57   HGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFIIIDPDTGKRVV 236
            HGQ+ TNY +G GIADITG  A V+MMGYA P Q + G+H+RQ SRAF+I D     R+V
Sbjct: 21   HGQT-TNYIIGAGIADITGPAAEVDMMGYANPAQTSKGIHLRQYSRAFVIADAANKSRIV 79

Query: 237  FVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYLQYALYQITSFG 416
            FVS D  M S  ++   +++L+  +GDLYN+ NVAISGTHTH+GP G+ QY LY +TS G
Sbjct: 80   FVSTDSCMQSQGLKLEIIKRLRSKYGDLYNERNVAISGTHTHSGPGGFHQYLLYDVTSLG 139

Query: 417  YFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYEQNPEEERSQYK 596
            +  E   ++  GI  SI KAHNS++P +++V+TGELL +NINRSP +Y  NP EER++YK
Sbjct: 140  FVNETFVSLVEGIVASIDKAHNSMKPGNLYVNTGELLESNINRSPTAYLNNPAEERAKYK 199

Query: 597  YNVDKEMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTASYFLEREYNNGT 776
            Y+VDK M +L+ T+ + + IG INWF VH  SM N N L+S DNKG A+   E + N G 
Sbjct: 200  YDVDKNMTVLRMTDAQNNGIGMINWFAVHCTSMNNTNHLISSDNKGLAAQMFEADMNKGG 259

Query: 777  LPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETCFGRGYGYLTGD 956
             PG+   + AFA SN GD SPN  GP+C DTG PC+  TSTCNG+ E C   G G    D
Sbjct: 260  FPGKGKFVAAFAQSNEGDVSPNTKGPHCMDTGKPCDVPTSTCNGRNELCVSPGPG---KD 316

Query: 957  DIYATRKIAELHVTKAKELI-DTAKTPITGSIDYKFTKVDIQNYNFTLNGKT-VSLCKAA 1130
               +TR IA     KAK L  D A   + G +D++ T VD+ +    +N  T V  CK A
Sbjct: 317  MFDSTRIIASNQYKKAKILYSDPAGMKLEGPVDFRHTYVDMSSVMVQINQTTKVKTCKPA 376

Query: 1131 LGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPKPIVLATGEM 1310
            +G+S  AGTTDGPG FNF QG  +T NPFW  I   +K+PT E + CQ PKPI+L TGEM
Sbjct: 377  MGFSFAAGTTDGPGAFNFTQG-ATTDNPFWDFIRDFLKKPTPEQLACQHPKPILLDTGEM 435

Query: 1311 RSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGVIDENGIVVV 1490
             +PY ++PSI+++Q+ +IG   I  VP EF+TMSGRR   ++   L   G    N + V+
Sbjct: 436  TAPYAWSPSIVDLQIFRIGQLAIISVPAEFSTMSGRRTRDSITATLKAAG-FPANTVSVI 494

Query: 1491 SGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADNLYVPIGPEA 1670
            +G +N Y  Y+TT EEY VQRYEG STIYGP+TL A++Q +  L+ ALA     P GP  
Sbjct: 495  AGLTNDYADYVTTYEEYQVQRYEGASTIYGPHTLQAFIQEFNKLADALAKGTPSPKGPTP 554

Query: 1671 PDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEVEFVGGHPKNRIQLEGS 1850
            P+  DK L+F+ PV+ D  P   KFGDV  DAN +Y +G++V+V F+G +P+N ++LE +
Sbjct: 555  PNLLDKQLSFLPPVVFDHAPFGSKFGDVVVDANSQYKQGDSVKVTFIGANPRNNVKLEDT 614

Query: 1851 FLYVQRLENNNNWINFKNDGDITTQFKW------LGNSIVRITWEIGDDVEAGTYRIFYQ 2012
            FL V+ L+ +NNW     D    T+F+W      LG S V ITW+I      GTYRI Y 
Sbjct: 615  FLSVEMLQPDNNWKVVFTDSQWETKFEWKHTSLLLGESEVTITWDIPQSQAPGTYRIQYF 674

Query: 2013 GHHKQLGGKIVPEFGTTS 2066
            G  K L  KI    G ++
Sbjct: 675  GDAKSLDQKITSFTGKST 692


>ref|XP_013094566.1| PREDICTED: neutral ceramidase-like isoform X1 [Biomphalaria glabrata]
          Length = 711

 Score =  616 bits (1588), Expect = 0.0
 Identities = 327/694 (47%), Positives = 433/694 (62%), Gaps = 7/694 (1%)
 Frame = +3

Query: 3    YILYILLMVTTQLNQNLVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIR 182
            + L +LL++ T  N          +Y VG+GIADITG  A VNMMGYA PGQ + G+H+R
Sbjct: 12   HYLPVLLLIFTIPNSK--------SYYVGVGIADITGPAAEVNMMGYANPGQTSHGIHLR 63

Query: 183  QRSRAFIIIDPDTGKRVVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTH 362
            Q SRAFI  +  + KR VFVS D      AV+R  ++ LK  FGDLY + N+A+SGTHTH
Sbjct: 64   QFSRAFIFAESLSSKRTVFVSLDACWSPGAVKRLVVQILKNKFGDLYTERNIAVSGTHTH 123

Query: 363  AGPAGYLQYALYQITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNIN 542
             G  G+ QY L+ +T+ G+ ++N  A+  G   SI+ AH ++QPA IF+++GELL++NIN
Sbjct: 124  GGSGGFSQYLLFDLTALGFNQQNFGALVDGTLQSIINAHENLQPADIFMNSGELLDSNIN 183

Query: 543  RSPFSYEQNPEEERSQYKYNVDKEMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSG 722
            RSP +Y  NP EERS+YKY+VDKEM++LKF N+ G  IG I+WF VH  SM N N +++ 
Sbjct: 184  RSPTAYLNNPAEERSKYKYDVDKEMVVLKFVNQTGHGIGMISWFAVHGTSMNNTNKMLTS 243

Query: 723  DNKGTASYFLEREYNNGTLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTC 902
            DNKG AS   E+++N G LPG+ T + AFA SNLGD SPN  GP+C DTGLPC+  TSTC
Sbjct: 244  DNKGYASLLFEQQFNPGALPGKGTFVAAFAQSNLGDVSPNTKGPHCLDTGLPCDAITSTC 303

Query: 903  NGKKETCFGRGYGYLTGDDIYATRKIAELHVTKAKELIDTAKTPITGSIDYKFTKVDIQN 1082
            NGK E C   G G    D   +T+ IA     KA EL ++A+  ITG +D++ + +++  
Sbjct: 304  NGKNELCVAFGPG---KDMFESTQIIANNQYQKALELYNSAQIKITGPVDFRHSYINMTQ 360

Query: 1083 YNFTL-NGKTVSLCKAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKE 1259
                L NG  V  CK A+GYS  AGTTDGPG F+F QG NS+ NPFW L+  +IK+PT+ 
Sbjct: 361  QVVPLANGTKVQTCKPAMGYSFAAGTTDGPGAFDFKQGSNSS-NPFWNLVRDLIKEPTEN 419

Query: 1260 TIECQRPKPIVLATGEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVK 1439
               C  PKPI+L TGE+  PY + P I++ Q+L+IG F+I  VPGEFTTMSGRR+   V 
Sbjct: 420  QKRCHFPKPILLDTGEISLPYFWQPQIVDNQILRIGQFVIIAVPGEFTTMSGRRMRDNVY 479

Query: 1440 NILMKKGVIDENGIVVVSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTD 1619
              L  +G    +   V++G +N Y  YI T EEY  QRYE  STI+GP+TL AYLQ +  
Sbjct: 480  LALTSQG-FPADTKTVIAGLANEYADYIATYEEYQQQRYEAASTIFGPHTLEAYLQTFRS 538

Query: 1620 LSIALADNLYVPIGPEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVE 1799
            L+I +A     P GP  P+  DK ++ +  VI D  P   +FG V KDA   Y  G TV 
Sbjct: 539  LAIQMAQGQPSPPGPTPPNQLDKQISLLPGVIFDSAPSGTQFGSVVKDAESTYTAGSTVT 598

Query: 1800 VEFVGGHPKNRIQLEGSFLYVQRLENNNNWINFKNDGDITTQFKW------LGNSIVRIT 1961
            V FV  +P+N ++   +FL V+  EN +NW+    D +  T+FKW      LG+S   I 
Sbjct: 599  VTFVSANPRNDLRTGDTFLTVEHKENGDNWVVLYADANWETRFKWVQTSLILGHSQAEIM 658

Query: 1962 WEIGDDVEAGTYRIFYQGHHKQLGGKIVPEFGTT 2063
            WEI  D   G YRI + G  K + G   P  G T
Sbjct: 659  WEIPKDQIPGVYRIRHFGTSKSIIGSKTPFVGQT 692


>ref|XP_014680017.1| PREDICTED: neutral ceramidase-like [Priapulus caudatus]
          Length = 759

 Score =  615 bits (1586), Expect = 0.0
 Identities = 329/692 (47%), Positives = 421/692 (60%), Gaps = 8/692 (1%)
 Frame = +3

Query: 18   LLMVTTQLNQNLVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRA 197
            L+ + T L  N  +G    N+ +G G ADITG  A +NMMGYA P Q   G+H R  SRA
Sbjct: 9    LMWLVTFLVYNGANGLDQPNFFIGTGRADITGPAAEINMMGYANPKQDTQGIHFRLYSRA 68

Query: 198  FIIIDPDTGKRVVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAG 377
            FII D     RVV+VSAD+AM S  ++   ++KLK  +GD+Y + NV +S  HTH+GP G
Sbjct: 69   FIIADHANSHRVVYVSADIAMVSQIIKIEVVKKLKTHYGDIYTEMNVCLSSIHTHSGPGG 128

Query: 378  YLQYALYQITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFS 557
            +LQY LY ITS G+  E+T+AI  GI  SI  AH  + P  IF++ G LL++NINRSP +
Sbjct: 129  FLQYLLYDITSLGFVAESTDAIVNGIVKSIQIAHERLVPGDIFINRGTLLDSNINRSPTA 188

Query: 558  YEQNPEEERSQYKYNVDKEMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGT 737
            Y  NP+EER +Y+Y+VDK+M++LK  N  G  IG I+WF VH  SM N N L+SGDNKG 
Sbjct: 189  YLNNPQEERDRYQYDVDKDMVVLKMVNSTGAAIGMISWFAVHCTSMNNTNHLISGDNKGY 248

Query: 738  ASYFLEREYNNGTLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKE 917
            ASY  E+  N G+LPGE   + AFA +N GD SPN  GP+C DTGLPC   TSTCNGK E
Sbjct: 249  ASYLFEQHMNPGSLPGEGDFVAAFAQANEGDVSPNTRGPHCLDTGLPCHMNTSTCNGKSE 308

Query: 918  TCFGRGYGYLTGDDIYATRKIAELHVTKAKELIDTAKTPITGSIDYKFTKVDIQNYNFTL 1097
             C   G G    D   +TR I      KA  L + A   ++G +D+K   VD+ N    L
Sbjct: 309  LCVAFGPGVDMAD---STRIIGNNQFIKALNLYNNATRKLSGPVDFKHQNVDMTNVQVNL 365

Query: 1098 -NGKTVSLCKAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQ 1274
             +G     CK A+GYS  AGTTDGPG  +F QG  + GN  W LI   IK+P+ E   CQ
Sbjct: 366  SDGSQAHTCKPAMGYSFAAGTTDGPGAMDFTQG-TTQGNALWNLIRNFIKKPSAEQTACQ 424

Query: 1275 RPKPIVLATGEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMK 1454
             PKPI+L TGE+  PY + P I+E+QLL++G+FII  VPGEF+TMSGRR+   V   L +
Sbjct: 425  LPKPILLDTGEISYPYSWQPDIVELQLLRVGDFIIVAVPGEFSTMSGRRVRSNVTATLAQ 484

Query: 1455 KGVIDENGIVVVSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIAL 1634
             G   E    V++G SN+Y+ YITT EEY VQRYEG STIYGP+TL AY+Q +  L+ A+
Sbjct: 485  HG-FPETTETVIAGLSNTYSSYITTFEEYQVQRYEGASTIYGPHTLQAYIQHFNVLAAAI 543

Query: 1635 ADNLYVPIGPEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEVEFVG 1814
            A N  V  GP  P   DK L FVLPV+ D   + K FGDV  DA  KY+   TV V FV 
Sbjct: 544  AQNSTVDKGPSVPYLRDKQLCFVLPVVYDGSGIGKSFGDVLTDAKPKYVVNTTVSVSFVA 603

Query: 1815 GHPKNRIQLEGSFLYVQRLE-NNNNWINFKNDGDITTQFKW------LGNSIVRITWEIG 1973
            GHP+N +    +FL V+      + W     D    T+FKW      LG S   + W+I 
Sbjct: 604  GHPRNNLMTGATFLTVEWWNPEQSTWHVAYTDSSWETRFKWTRTSSLLGKSQATVEWDIP 663

Query: 1974 DDVEAGTYRIFYQGHHKQLGGKIVPEFGTTSN 2069
                 G YR+ + GH K + G I P  GT+++
Sbjct: 664  AAAMPGVYRMRHFGHEKSVTGDIHPYAGTSAS 695


>ref|XP_023932283.1| neutral ceramidase isoform X1 [Lingula anatina]
          Length = 699

 Score =  612 bits (1577), Expect = 0.0
 Identities = 311/664 (46%), Positives = 421/664 (63%), Gaps = 8/664 (1%)
 Frame = +3

Query: 63   QSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFIIIDPDTGKRVVFV 242
            Q V NY +G GIAD+TG  A VNMMGYA P Q + G+H+R  SRAFII D     RVVFV
Sbjct: 24   QGVANYYIGAGIADVTGPAAEVNMMGYANPSQKSHGIHMRLYSRAFIIADAAKTSRVVFV 83

Query: 243  SADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYLQYALYQITSFGYF 422
            + D  M S  +++    KLK  +  LY++ NV +SGTHTH+GP GY +Y L+ +TS G+ 
Sbjct: 84   NVDACMISDIMKKKVANKLKTLYNGLYDETNVCVSGTHTHSGPGGYHRYVLFDVTSLGFV 143

Query: 423  KENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYEQNPEEERSQYKYN 602
            +E+ + +  GI  SI  AHN++   +I+++TG LLN+NINRSP +Y  NP  E+++Y YN
Sbjct: 144  EESLDPLVDGIVKSIQNAHNNMVAGNIYINTGVLLNSNINRSPTAYLNNPPGEKAKYNYN 203

Query: 603  VDKEMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTASYFLEREYNNGTLP 782
            VDK+M +LKF +  G  +G I+WF VH  SM N N  +SGDNKG A+   ERE N G+LP
Sbjct: 204  VDKDMTVLKFVDGNGQPLGMISWFAVHCTSMNNTNGYISGDNKGYAAQLFEREMNPGSLP 263

Query: 783  GEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETCFGRGYGYLTGDDI 962
            GE   I AFA SN GD SPN  G +C DTG PC+  TSTCNGK E C   G     G D+
Sbjct: 264  GEGKFIAAFAQSNEGDVSPNTKGAHCIDTGKPCDVSTSTCNGKPELCVASG----PGKDM 319

Query: 963  Y-ATRKIAELHVTKAKELIDTAKTPITGSIDYKFTKVDIQNYNFTLNG-KTVSLCKAALG 1136
            Y +T+ I +    KAKEL D A T +TG +DY+   VD+ N    ++     + C  A+G
Sbjct: 320  YESTKIIGKKQYEKAKELFDGANTLLTGPVDYRHQFVDMSNQKVQIDATHYATTCPPAMG 379

Query: 1137 YSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPKPIVLATGEMRS 1316
            YS  AGTTDGPG F+F QG  +TGNPFW  +  I+ +P++  I+CQ PKPI+L TGEM  
Sbjct: 380  YSFAAGTTDGPGSFDFTQG-TTTGNPFWNFVRNILSKPSRAQIQCQHPKPILLNTGEMSF 438

Query: 1317 PYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGVIDENGIVVVSG 1496
            PY + PS++  Q+L+IG  +I  VPGEF+TMSGRRL   V  I  ++G +  N   VV+G
Sbjct: 439  PYPWQPSVVPTQILRIGELMILAVPGEFSTMSGRRLRNAVTEIATQQG-LPSNTKTVVAG 497

Query: 1497 PSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADNLYVPIGPEAPD 1676
             SNSY  Y+ T EEY +QRYEG STIYGP+TL A++Q +  L+ A+A    +  GP  P+
Sbjct: 498  LSNSYADYVVTYEEYQIQRYEGASTIYGPHTLLAFIQKFKGLTTAMAQGSTLSSGPSTPN 557

Query: 1677 FTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEVEFVGGHPKNRIQLEGSFL 1856
            F  K ++F+ PV+ D PPLF+ FGDV K    KYI+G+ V+V F+  +P+N +    SFL
Sbjct: 558  FPSKLISFLTPVLHDSPPLFRSFGDVIKQPKSKYIQGDVVKVSFISANPRNNVMSGKSFL 617

Query: 1857 YVQRLENNNNWINFKNDGDITTQFKW------LGNSIVRITWEIGDDVEAGTYRIFYQGH 2018
             V++ +++ +W     D D  T + W      L  S+  I+W+I D    GTYRI + G 
Sbjct: 618  TVEKKQSDGSWKTVFTDADWETSYYWKRTSTILALSVSEISWKIPDQQPKGTYRIRHFGT 677

Query: 2019 HKQL 2030
             K++
Sbjct: 678  AKKM 681


>ref|XP_013402701.1| neutral ceramidase isoform X2 [Lingula anatina]
          Length = 696

 Score =  610 bits (1572), Expect = 0.0
 Identities = 310/662 (46%), Positives = 420/662 (63%), Gaps = 8/662 (1%)
 Frame = +3

Query: 69   VTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFIIIDPDTGKRVVFVSA 248
            V NY +G GIAD+TG  A VNMMGYA P Q + G+H+R  SRAFII D     RVVFV+ 
Sbjct: 23   VANYYIGTGIADVTGPAAEVNMMGYANPSQKSHGIHMRLYSRAFIIADAAKTSRVVFVNV 82

Query: 249  DLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYLQYALYQITSFGYFKE 428
            D  M S  +++    KLK  +  LY++ NV +SGTHTH+GP GY +Y L+ +TS G+ +E
Sbjct: 83   DACMISDIMKKKVANKLKTLYNGLYDETNVCVSGTHTHSGPGGYHRYVLFDVTSLGFVEE 142

Query: 429  NTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYEQNPEEERSQYKYNVD 608
            + + +  GI  SI  AHN++   +I+++TG LLN+NINRSP +Y  NP  E+++Y YNVD
Sbjct: 143  SLDPLVDGIVKSIQNAHNNMVAGNIYINTGVLLNSNINRSPTAYLNNPPGEKAKYNYNVD 202

Query: 609  KEMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTASYFLEREYNNGTLPGE 788
            K+M +LKF +  G  +G I+WF VH  SM N N  +SGDNKG A+   ERE N G+LPGE
Sbjct: 203  KDMTVLKFVDGNGQPLGMISWFAVHCTSMNNTNGYISGDNKGYAAQLFEREMNPGSLPGE 262

Query: 789  ETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETCFGRGYGYLTGDDIY- 965
               I AFA SN GD SPN  G +C DTG PC+  TSTCNGK E C   G     G D+Y 
Sbjct: 263  GKFIAAFAQSNEGDVSPNTKGAHCIDTGKPCDVSTSTCNGKPELCVASG----PGKDMYE 318

Query: 966  ATRKIAELHVTKAKELIDTAKTPITGSIDYKFTKVDIQNYNFTLNG-KTVSLCKAALGYS 1142
            +T+ I +    KAKEL D A T +TG +DY+   VD+ N    ++     + C  A+GYS
Sbjct: 319  STKIIGKKQYEKAKELFDGANTLLTGPVDYRHQFVDMSNQKVQIDATHYATTCPPAMGYS 378

Query: 1143 MIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPKPIVLATGEMRSPY 1322
              AGTTDGPG F+F QG  +TGNPFW  +  I+ +P++  I+CQ PKPI+L TGEM  PY
Sbjct: 379  FAAGTTDGPGSFDFTQG-TTTGNPFWNFVRNILSKPSRAQIQCQHPKPILLNTGEMSFPY 437

Query: 1323 DFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGVIDENGIVVVSGPS 1502
             + PS++  Q+L+IG  +I  VPGEF+TMSGRRL   V  I  ++G +  N   VV+G S
Sbjct: 438  PWQPSVVPTQILRIGELMILAVPGEFSTMSGRRLRNAVTEIATQQG-LPSNTKTVVAGLS 496

Query: 1503 NSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADNLYVPIGPEAPDFT 1682
            NSY  Y+ T EEY +QRYEG STIYGP+TL A++Q +  L+ A+A    +  GP  P+F 
Sbjct: 497  NSYADYVVTYEEYQIQRYEGASTIYGPHTLLAFIQKFKGLTTAMAQGSTLSSGPSTPNFP 556

Query: 1683 DKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEVEFVGGHPKNRIQLEGSFLYV 1862
             K ++F+ PV+ D PPLF+ FGDV K    KYI+G+ V+V F+  +P+N +    SFL V
Sbjct: 557  SKLISFLTPVLHDSPPLFRSFGDVIKQPKSKYIQGDVVKVSFISANPRNNVMSGKSFLTV 616

Query: 1863 QRLENNNNWINFKNDGDITTQFKW------LGNSIVRITWEIGDDVEAGTYRIFYQGHHK 2024
            ++ +++ +W     D D  T + W      L  S+  I+W+I D    GTYRI + G  K
Sbjct: 617  EKKQSDGSWKTVFTDADWETSYYWKRTSTILALSVSEISWKIPDQQPKGTYRIRHFGTAK 676

Query: 2025 QL 2030
            ++
Sbjct: 677  KM 678


>ref|XP_013402699.1| neutral ceramidase [Lingula anatina]
          Length = 729

 Score =  611 bits (1575), Expect = 0.0
 Identities = 322/681 (47%), Positives = 430/681 (63%), Gaps = 12/681 (1%)
 Frame = +3

Query: 57   HGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFIIIDPDTGKRVV 236
            HG  V +Y +G GIAD+TG  A V+MMGYA P Q + G+H+RQ SRAFII D     RVV
Sbjct: 23   HG--VAHYYIGTGIADVTGPAAEVDMMGYANPAQTSHGIHLRQYSRAFIIADTAKKSRVV 80

Query: 237  FVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYLQYALYQITSFG 416
            FV+ D  M S  ++   ++KL+  +  LYND NV +SG HTH+GP G+ QY L+ +TS G
Sbjct: 81   FVNVDACMISEILKIQVVQKLQTLYHGLYNDSNVCLSGIHTHSGPGGFHQYVLFDVTSLG 140

Query: 417  YFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYEQNPEEERSQYK 596
            + KE+ +++  GI  SI  AHN++   +I+++TGELL++NINRSP +Y  NP EE+++YK
Sbjct: 141  FVKESLDSLVNGIVKSIQNAHNNMVAGNIYINTGELLDSNINRSPSAYLNNPAEEKARYK 200

Query: 597  YNVDKEMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTASYFLEREYNNGT 776
            YNVDK M +LKF +E    +G I+WF VH  SM N N  +SGDNKG A+   ERE N G+
Sbjct: 201  YNVDKNMTVLKFVDENAKPLGMISWFAVHCTSMNNTNGYISGDNKGYAAQLFEREMNPGS 260

Query: 777  LPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETCFGRGYGYLTGD 956
            LPGE   + AFA SN GD SPN  GP+C +TG PC+  TSTC GK E C   G     G 
Sbjct: 261  LPGEGKFVAAFAQSNEGDVSPNTKGPHCINTGKPCDILTSTCEGKNELCIASG----PGR 316

Query: 957  DIY-ATRKIAELHVTKAKELIDTAKTPITGSIDYK--FTKVDIQ--NYNFTLNGKTVSLC 1121
            D+Y +T+ I      KAKEL  +A T +TG +DY+  F  + IQ    N T N  T   C
Sbjct: 317  DMYESTKIIGGNQFKKAKELFHSASTLLTGPVDYRHQFVNMSIQIVQVNATHNATT---C 373

Query: 1122 KAALGYSMIAGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPKPIVLAT 1301
              A+GYS  AGTTDGPG F+F QG ++T NPFW +I   + +PT + I+CQ PKPI+L T
Sbjct: 374  PPAMGYSFAAGTTDGPGMFDFTQG-STTSNPFWNVIRDFLSKPTPQQIKCQHPKPILLNT 432

Query: 1302 GEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGVIDENGI 1481
            GE+  PY + PS++  Q+L+IG  +I  VPGEF+TMSGRRL   +  I ++ G    N  
Sbjct: 433  GEISFPYPWQPSVVPTQILRIGELMILAVPGEFSTMSGRRLRNAITEIAIQHG-FPSNTT 491

Query: 1482 VVVSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADNLYVPIG 1661
             VV+G SN+Y  YI T EEY +QRYEG STI+GP+TL AY+Q +  L++A+A    VP+G
Sbjct: 492  TVVAGLSNAYADYIATYEEYQIQRYEGASTIFGPHTLQAYIQKFKTLTVAMARGSPVPVG 551

Query: 1662 PEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEVEFVGGHPKNRIQL 1841
            P  P+F  +  +F+ PV+ D  P+ + FGDV K  N KY+ G TVEV F+  +P+N +  
Sbjct: 552  PSPPNFMKELFSFLPPVLFDHAPMGQNFGDVVKKPNPKYMPGGTVEVSFISANPRNNLMS 611

Query: 1842 EGSFLYVQRLENNNNWINFKNDGDITTQFKW------LGNSIVRITWEIGDDVEAGTYRI 2003
              SFL V+  +++ +W     D D  T + W      LG SI  ITW I D    GTYRI
Sbjct: 612  GKSFLTVEMKQSDGSWKTMFTDADWETSYHWERTSTILGESISVITWNIPDQQMPGTYRI 671

Query: 2004 FYQGHHK-QLGGKIVPEFGTT 2063
             + G  K  +GG I P  G+T
Sbjct: 672  RHFGSSKSMIGGSITPFEGST 692


>ref|XP_019620212.1| PREDICTED: neutral ceramidase-like isoform X1 [Branchiostoma
            belcheri]
          Length = 756

 Score =  608 bits (1567), Expect = 0.0
 Identities = 322/710 (45%), Positives = 430/710 (60%), Gaps = 47/710 (6%)
 Frame = +3

Query: 75   NYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFIIIDPDTGKRVVFVSADL 254
            NY VG+G AD+TG  A VNMMGYA P Q +SG+H RQ SRAFI+ DP    R VFVS D 
Sbjct: 45   NYLVGVGRADVTGPAAEVNMMGYANPAQQSSGIHFRQFSRAFIVSDPQNTTRTVFVSVDC 104

Query: 255  AMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYLQYALYQITSFGYFKENT 434
            AM S  ++   ++KLK  FG+ YN+ NV +S  HTH+GPAG+LQY L+ +TS G+ +E+ 
Sbjct: 105  AMVSQILKIEVVKKLKPLFGNAYNESNVCLSAIHTHSGPAGFLQYVLFDVTSLGFVRESF 164

Query: 435  EAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYEQNPEEERSQYKYNVDKE 614
             A+  GI  SI +AHN++ P  ++++ GEL + NINRSP +Y  NPE ER++Y  N DK 
Sbjct: 165  NALVDGIVASIQRAHNNVVPGDLYLNQGELQDANINRSPTAYLNNPESERAKYDANTDKN 224

Query: 615  MILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTASYFLEREYNNGTLPGEET 794
            M++LKF ++ G  +G I+WF VH  SM N N L+SGDNKG AS   E + N G+L G+ +
Sbjct: 225  MVVLKFVDQHGTGLGMISWFAVHCTSMNNTNGLISGDNKGYASQLFEADMNPGSLAGQGS 284

Query: 795  IIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETCFGRGYGYLTGDDIYATR 974
             + AFA SN GD SPN  GP+C DTGL C+  TSTCNGK E C   G G    D   +TR
Sbjct: 285  FVAAFAQSNEGDVSPNTRGPHCQDTGLACDLETSTCNGKSELCVSPGPGV---DMFDSTR 341

Query: 975  KIAELHVTKAKELIDT-AKTPITGSIDYKFTKVDIQNYNFTLNGK-TVSLCKAALGYSMI 1148
             I     +KAKEL +  A+  ++G + +    VD+ +    +N   +   CK A+GYS  
Sbjct: 342  IIGHKQYSKAKELYNADAQEKLSGPVQFALQFVDMSDVTVQINSSYSAKTCKPAMGYSFA 401

Query: 1149 AGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPKPIVLATGEMRSPYDF 1328
            AGTTDGPG F+F QGD + GNPFW  +  IIKQP+ E + CQ PKPI+L TGEM  PY +
Sbjct: 402  AGTTDGPGAFDFTQGD-TEGNPFWNFVRNIIKQPSAEEVACQAPKPILLPTGEMTFPYAW 460

Query: 1329 TPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGVIDENGIVVVSGPSNS 1508
             P I++IQLL+ G  ++  VPGEF+TMSGRRL  +++  ++ KG + E+  VVV+G SN+
Sbjct: 461  QPDIVDIQLLRWGQLVVAAVPGEFSTMSGRRLRDSIQRAVVSKG-LPEDTEVVVAGLSNT 519

Query: 1509 YTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADNLYVPIGPEAPDFTDK 1688
            Y+ YITT EEY VQRYEG STIYGP+TL AY QLY+ L+  +     + IGP  P+   +
Sbjct: 520  YSDYITTYEEYQVQRYEGASTIYGPHTLAAYQQLYSQLAQDMVMGADIDIGPSPPNLLSR 579

Query: 1689 ALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEVEFVGGHPKNRIQ---------- 1838
             L+F+ PV++D  PLF  FG+V  DA   Y   ETV V F   HP+N +Q          
Sbjct: 580  QLSFLPPVVLDTTPLFTHFGEVITDAGSAYHTNETVSVRFHSAHPRNNLQTQPENMQKTV 639

Query: 1839 -----------------------------LEGSFLYVQRLENNNNWINFKNDGDITTQFK 1931
                                         L+GSFL V+R +++  +    ND    T +K
Sbjct: 640  RRRRGIFHFFSWAHKKLQKFLSGPDEEAELDGSFLTVERKKDDGTFEVVHNDASWDTMYK 699

Query: 1932 W------LGNSIVRITWEIGDDVEAGTYRIFYQGHHKQLGGKIVPEFGTT 2063
            W      +G+S   ITW I      GTYRI + GH K L G+I P  G++
Sbjct: 700  WKRTNVLVGHSEATITWTISPGTPPGTYRIRHFGHSKNLVGEITPFVGSS 749


>ref|XP_005100690.1| PREDICTED: neutral ceramidase-like [Aplysia californica]
          Length = 696

 Score =  603 bits (1556), Expect = 0.0
 Identities = 316/672 (47%), Positives = 422/672 (62%), Gaps = 7/672 (1%)
 Frame = +3

Query: 72   TNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFIIIDPDTGKRVVFVSAD 251
            +NY VG+GIAD+TG  A +NMMGYA PGQ + GLH+RQ SRAFI        RV+FV+ D
Sbjct: 22   SNYYVGVGIADVTGPAADINMMGYANPGQTSHGLHMRQMSRAFIFAVSPASPRVIFVNLD 81

Query: 252  LAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGPAGYLQYALYQITSFGYFKEN 431
             A    AV+R  ++KLK+ FG+LY D+NV ISGTHTH+G  GY QY L+ IT+ G+  + 
Sbjct: 82   AAWAGGAVKRQVVQKLKKRFGNLYTDKNVCISGTHTHSGMGGYSQYLLFDITALGFNHQT 141

Query: 432  TEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYEQNPEEERSQYKYNVDK 611
             EA+  GI  SIVKAH+S+QPA ++V+ GELL +NINRSP +Y  NPE ER++Y +NVDK
Sbjct: 142  FEALVDGIVVSIVKAHDSMQPADLYVNKGELLESNINRSPTAYLNNPEAERAKYTHNVDK 201

Query: 612  EMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTASYFLEREYNNGTLPGEE 791
            +M++LK  +  G  IG I+WF VH  SM N N ++S DNKG A+   E  +N G+ PG+ 
Sbjct: 202  DMVVLKIVSSSGVDIGMISWFAVHCTSMNNTNQMISSDNKGYAAQQFENMFNPGSAPGKG 261

Query: 792  TIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETCFGRGYGYLTGDDIYAT 971
              + AFA SN GD SPN  GP+C DTG  C+  TSTCN + E C   G G    D   +T
Sbjct: 262  PFVAAFAQSNEGDVSPNTRGPHCLDTGKECDVPTSTCNDRNELCVAFGPG---KDMFEST 318

Query: 972  RKIAELHVTKAKELIDTAKTPITGSIDYKFTKVDIQNYNFTL-NGKTVSLCKAALGYSMI 1148
            + I      KA EL ++A   ++G +D++ +  D+   N +L NG  V  CK ++GYS  
Sbjct: 319  QIIGNNQFKKAVELYNSASFKLSGPVDFRHSFADMTIQNVSLSNGSKVQTCKPSMGYSFA 378

Query: 1149 AGTTDGPGGFNFIQGDNSTGNPFWKLITRIIKQPTKETIECQRPKPIVLATGEMRSPYDF 1328
            AGTTDGPG F+F QG  +T NPFW  +  +I+ P+ E ++CQ PKPI+L TGE+  PY +
Sbjct: 379  AGTTDGPGAFDFKQG-TTTSNPFWNFVRDLIEDPSPELVKCQEPKPILLPTGEITKPYLW 437

Query: 1329 TPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMKKGVIDENGIVVVSGPSNS 1508
             P I++ QLL++G F+I  VPGEF+TMSGRR+   V +IL++ G    N   V+ G  N 
Sbjct: 438  QPQIVDTQLLRLGQFVIIAVPGEFSTMSGRRMRDAVSSILIQGG-FPANTSTVIGGLCNE 496

Query: 1509 YTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIALADNLYVPIGPEAPDFTDK 1688
            Y  YITT EEY +QRYEG ST YGP TL AY+QLY  L+ A+A     P GP  P+  D 
Sbjct: 497  YADYITTYEEYQIQRYEGASTTYGPYTLAAYIQLYRQLASAMAKGTPSPDGPTPPNLLDV 556

Query: 1689 ALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEVEFVGGHPKNRIQLEGSFLYVQR 1868
             LNFV  VI D+ P  ++FG V +DAN  Y  G  V V F   +P+N ++  G+FL V+R
Sbjct: 557  QLNFVPGVIFDLAPSGEEFGSVLQDANPSYRAGSQVTVRFQSANPRNNLRTNGTFLSVER 616

Query: 1869 LENNNNWINFKNDGDITTQFKW------LGNSIVRITWEIGDDVEAGTYRIFYQGHHKQL 2030
             + +  WI   +D    T+F W      LG S   I W+I    ++GTYRI + G  K +
Sbjct: 617  KDESGRWIIAFSDSYWETRFHWIRTETFLGYSEALIIWDIPIGQKSGTYRIQHFGTSKTV 676

Query: 2031 GGKIVPEFGTTS 2066
             G +    GTTS
Sbjct: 677  TGTLTNFVGTTS 688


>gb|KVI11923.1| Neutral/alkaline nonlysosomal ceramidase [Cynara cardunculus var.
            scolymus]
          Length = 727

 Score =  603 bits (1554), Expect = 0.0
 Identities = 315/710 (44%), Positives = 437/710 (61%), Gaps = 33/710 (4%)
 Frame = +3

Query: 12   YILLMVTTQLNQNLVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRS 191
            ++LL+V     +  +   S +NY VG+G  DITG  A VNMMGYA   Q ASG+H R R+
Sbjct: 18   WVLLLVFAHNGKKTI---SASNYLVGLGSYDITGPAADVNMMGYANSDQTASGIHFRLRA 74

Query: 192  RAFIIIDPDTGKRVVFVSADLAMGSLAVRRATLEKLKESFGDLYNDENVAISGTHTHAGP 371
            R+FI+ +P  G RVVFV+ D  M S  V    LE+LK  +G+LY ++NVAISG HTHAGP
Sbjct: 75   RSFIVAEPQ-GNRVVFVNLDACMASQLVTIKVLERLKARYGNLYTEKNVAISGIHTHAGP 133

Query: 372  AGYLQYALYQITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSP 551
             GYLQY +Y +TS G+ +++ + I  GI  SI++AH +++  S++V+ GE+L+  +NRSP
Sbjct: 134  GGYLQYVVYIVTSLGFVRQSFDVIVDGIEQSIMRAHENLRAGSVYVNKGEILDAGVNRSP 193

Query: 552  FSYEQNPEEERSQYKYNVDKEMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNK 731
             SY  NP  ERS+YKY+VDKE+ LLKF +++   +G+ NWF  H  SM   N L+SGDNK
Sbjct: 194  SSYLNNPAAERSKYKYDVDKEITLLKFVDDQWGPVGAFNWFATHGTSMSRTNELISGDNK 253

Query: 732  GTASYFLEREYN---------------NGTLPGEE-----TIIHAFANSNLGDSSPNIFG 851
            GTA+  +E  ++               +  +PG +       + AF  SN GD SPN+ G
Sbjct: 254  GTAARLMEDWFDQKSVGGIANEIPRRVSNIVPGTQGNHRPKFVSAFCQSNCGDVSPNVLG 313

Query: 852  PYCADTGLPCEYRTSTCNGKKETCFGRGYGYLTGDDIYATRKIAELHVTKAKELIDTAKT 1031
             +C DTGLPC++  STC GK E C+GRG GY   D+  +TR I E    KA EL ++A  
Sbjct: 314  AFCTDTGLPCDFNHSTCGGKNELCYGRGPGY--PDEFESTRIIGERQFKKATELFNSASQ 371

Query: 1032 PITGSIDYKFTKVDIQNYNFTL-----NGKTVSLCKAALGYSMIAGTTDGPGGFNFIQGD 1196
             + G ID++ T +D      TL       +TV  C AA+G++  AGTTDGPG F+F QGD
Sbjct: 372  KLNGKIDFRHTYLDFSQLEVTLPKQGGGSETVKTCPAAMGFAFAAGTTDGPGAFDFKQGD 431

Query: 1197 NSTGNPFWKLITRIIKQPTKETIECQRPKPIVLATGEMRSPYDFTPSIIEIQLLKIGNFI 1376
            +S GN FWKL+  ++K P+KE  +CQ+PKPI+L TGEM+ PYD+ PSI+ IQ+LKIG  +
Sbjct: 432  DS-GNAFWKLVRNVLKTPSKEQTDCQQPKPILLDTGEMKQPYDWAPSILPIQILKIGQLV 490

Query: 1377 ICVVPGEFTTMSGRRLTKTVKNILMKKGVIDENGIVVVSGPSNSYTHYITTPEEYLVQRY 1556
            I  VPGEFTTM+GRRL   V        V  E   VV++G +N+Y+ Y+TT EEY +QRY
Sbjct: 491  ILSVPGEFTTMAGRRLRDAV------GAVFKEKVQVVIAGLTNTYSQYVTTLEEYKMQRY 544

Query: 1557 EGGSTIYGPNTLNAYLQLYTDLSIALADNLYVPIGPEAPDFTDKALNFVLPVIVDIPPLF 1736
            EG ST+YGP+TL+AY+Q +T L+ A+     V  GP+ PD  +K ++ + PV+VD  PL 
Sbjct: 545  EGASTLYGPHTLSAYIQEFTKLATAIVSGKPVEAGPQPPDLLNKQISLLAPVVVDSTPLG 604

Query: 1737 KKFGDVTKD--ANKKYIRGETVEVEFVGGHPKNRIQLEGSFLYVQRLENNNNWINFKNDG 1910
              FGDV+ +   N  + +G+TV V F    P+N +  EG+F  V+ L+  + W+   +D 
Sbjct: 605  VGFGDVSTNIPRNSTFKKGDTVSVVFWSACPRNDLMTEGTFALVELLQGQDTWVPAYDDD 664

Query: 1911 DITTQFKW------LGNSIVRITWEIGDDVEAGTYRIFYQGHHKQLGGKI 2042
            DI  +FKW         S   I W +      G YR+ + G  K L G I
Sbjct: 665  DICLRFKWSRPSKLSAQSHATIEWRVPQSAVPGVYRVSHFGASKSLFGSI 714


>ref|XP_647372.1| neutral/alkaline nonlysosomal ceramidase family protein
            [Dictyostelium discoideum AX4]
 sp|Q55G11.1|NCSEB_DICDI RecName: Full=Neutral ceramidase B; Short=N-CDase B; Short=NCDase B;
            AltName: Full=Acylsphingosine deacylase 2B; AltName:
            Full=N-acylsphingosine amidohydrolase 2B; Flags:
            Precursor
 gb|EAL73640.1| neutral/alkaline nonlysosomal ceramidase family protein
            [Dictyostelium discoideum AX4]
          Length = 718

 Score =  596 bits (1536), Expect = 0.0
 Identities = 320/691 (46%), Positives = 429/691 (62%), Gaps = 14/691 (2%)
 Frame = +3

Query: 39   LNQNLVHGQSVTNYNVGIGIADITGIVAGVNMMGYAMPGQIASGLHIRQRSRAFIIIDPD 218
            +NQ  V     ++Y +G GI DITG  A VN+MGYA P Q+ +G+H RQR+RAF+ +D +
Sbjct: 33   VNQKNVKSSGDSSYQIGAGIYDITGASAEVNLMGYANPLQVGAGIHFRQRARAFVFVDSN 92

Query: 219  TGKRVVFVSADLAMGSLAVRRATLEKLKESFG-DLYNDENVAISGTHTHAGPAGYLQYAL 395
             G R V+VS D  M    V+   +E L++ FG ++Y + NV +SGTHTH+GPAG+ QYAL
Sbjct: 93   -GNRAVYVSTDSCMIFQEVKIHVVELLQDIFGPNVYTEANVLLSGTHTHSGPAGFSQYAL 151

Query: 396  YQITSFGYFKENTEAISTGIYNSIVKAHNSIQPASIFVSTGELLNTNINRSPFSYEQNPE 575
            Y ITS G++K+N + I  GI  +IVKAH S+QPA++F  TGEL NTNINRSPF+Y+ NPE
Sbjct: 152  YGITSLGFYKKNFDTICNGIVQAIVKAHKSVQPANMFTETGELWNTNINRSPFAYDNNPE 211

Query: 576  EERSQYKYNVDKEMILLKFTNEKGDVIGSINWFPVHPVSMMNNNTLVSGDNKGTASYFLE 755
            EE++ Y  NVDK M +L+  +  G+   +I++F VH  SM N N L+SGDNKG ASY  E
Sbjct: 212  EEKAMYDSNVDKNMTVLRIEDMNGNPFAAISFFAVHCTSMNNTNHLISGDNKGYASYLWE 271

Query: 756  REYNNGTLPGEETIIHAFANSNLGDSSPNIFGPYCADTGLPCEYRTSTCNGKKETCFGRG 935
            ++ N     G+   + AF  SN GD SPN  GP C D G PC+Y+TSTCNG+ E C+  G
Sbjct: 272  KQVNGPGTAGKGPFVAAFGQSNEGDVSPNTRGPTCRD-GSPCDYKTSTCNGRNEECWSLG 330

Query: 936  YGYLTGDDIYATRKIAELHVTKAKELIDTAKTPITGSIDYK-----FTKVDIQ-NYNFTL 1097
             G   GD   +T+ I      KA EL + A   ++G + Y+     FT V ++  YN  +
Sbjct: 331  PG-KDGDMFESTQIIGGNQFNKALELFNNASIQVSGPVQYRHSWVQFTNVSVEPPYNSGV 389

Query: 1098 NGKTVSLCKAALGYSMIAGTTDGPGGFNFIQGDNST-GNPFWKLITRIIKQPTKETIECQ 1274
            +  T   C+ A+GYS  AGTTDGPG FNF+Q DN+T GNPFW  I   I +PT + I CQ
Sbjct: 390  DNATT--CRGAMGYSFAAGTTDGPGAFNFVQSDNNTSGNPFWNFIGDFIAKPTPDQIRCQ 447

Query: 1275 RPKPIVLATGEMRSPYDFTPSIIEIQLLKIGNFIICVVPGEFTTMSGRRLTKTVKNILMK 1454
             PKPI+L  G M  P  + P ++ IQ++ IG  ++  VPGEFTTMSGRRL  +V+ I+  
Sbjct: 448  SPKPILLDVG-MVEPIPWVPDVMPIQIVTIGQIVLVAVPGEFTTMSGRRLRNSVREII-- 504

Query: 1455 KGVIDENGIVVVSGPSNSYTHYITTPEEYLVQRYEGGSTIYGPNTLNAYLQLYTDLSIAL 1634
             G   EN IV+++G SN+Y+ YI T EEY VQRYEG ST++GP+TL +Y+Q +  L+ ++
Sbjct: 505  -GESIENPIVLIAGLSNTYSGYIATFEEYQVQRYEGASTVFGPHTLGSYMQEFGKLAQSI 563

Query: 1635 ADNLYVPIGPEAPDFTDKALNFVLPVIVDIPPLFKKFGDVTKDANKKYIRGETVEVEFVG 1814
             D   VP GP   + T   L F+ PVIVD  P F  FG+V+ D N  Y   ETV   F G
Sbjct: 564  VDGTTVPAGPTPRNLTGHTLFFLPPVIVDAAPDFDDFGEVSIDVNLNYSVNETVSCVFYG 623

Query: 1815 GHPKNRIQLEGSFLYVQRLENNNNWINFKNDGDITTQFKW----LGNSIVRITWEIGDDV 1982
            G+P+N   +E SFL V  L   + W    +DGD  T+FKW    LG S++ I W I  D 
Sbjct: 624  GNPRNDFMIESSFLSVDLLTGTDQWTTVLDDGDWDTKFKWKMHDLGFSLITIEWVIAPDT 683

Query: 1983 EAGTYRIFYQGHHKQ--LGGKIVPEFGTTSN 2069
              GTYRI + G  K+      + P  G + N
Sbjct: 684  TPGTYRITHSGFAKKNPFSSNLTPYQGISRN 714


>ref|XP_013094635.1| PREDICTED: neutral ceramidase-like isoform X2 [Biomphalaria glabrata]
          Length = 664

 Score =  589 bits (1518), Expect = 0.0
 Identities = 308/650 (47%), Positives = 408/650 (62%), Gaps = 7/650 (1%)
 Frame = +3

Query: 135  MGYAMPGQIASGLHIRQRSRAFIIIDPDTGKRVVFVSADLAMGSLAVRRATLEKLKESFG 314
            MGYA PGQ + G+H+RQ SRAFI  +  + KR VFVS D      AV+R  ++ LK  FG
Sbjct: 1    MGYANPGQTSHGIHLRQFSRAFIFAESLSSKRTVFVSLDACWSPGAVKRLVVQILKNKFG 60

Query: 315  DLYNDENVAISGTHTHAGPAGYLQYALYQITSFGYFKENTEAISTGIYNSIVKAHNSIQP 494
            DLY + N+A+SGTHTH G  G+ QY L+ +T+ G+ ++N  A+  G   SI+ AH ++QP
Sbjct: 61   DLYTERNIAVSGTHTHGGSGGFSQYLLFDLTALGFNQQNFGALVDGTLQSIINAHENLQP 120

Query: 495  ASIFVSTGELLNTNINRSPFSYEQNPEEERSQYKYNVDKEMILLKFTNEKGDVIGSINWF 674
            A IF+++GELL++NINRSP +Y  NP EERS+YKY+VDKEM++LKF N+ G  IG I+WF
Sbjct: 121  ADIFMNSGELLDSNINRSPTAYLNNPAEERSKYKYDVDKEMVVLKFVNQTGHGIGMISWF 180

Query: 675  PVHPVSMMNNNTLVSGDNKGTASYFLEREYNNGTLPGEETIIHAFANSNLGDSSPNIFGP 854
             VH  SM N N +++ DNKG AS   E+++N G LPG+ T + AFA SNLGD SPN  GP
Sbjct: 181  AVHGTSMNNTNKMLTSDNKGYASLLFEQQFNPGALPGKGTFVAAFAQSNLGDVSPNTKGP 240

Query: 855  YCADTGLPCEYRTSTCNGKKETCFGRGYGYLTGDDIYATRKIAELHVTKAKELIDTAKTP 1034
            +C DTGLPC+  TSTCNGK E C   G G    D   +T+ IA     KA EL ++A+  
Sbjct: 241  HCLDTGLPCDAITSTCNGKNELCVAFGPG---KDMFESTQIIANNQYQKALELYNSAQIK 297

Query: 1035 ITGSIDYKFTKVDIQNYNFTL-NGKTVSLCKAALGYSMIAGTTDGPGGFNFIQGDNSTGN 1211
            ITG +D++ + +++      L NG  V  CK A+GYS  AGTTDGPG F+F QG NS+ N
Sbjct: 298  ITGPVDFRHSYINMTQQVVPLANGTKVQTCKPAMGYSFAAGTTDGPGAFDFKQGSNSS-N 356

Query: 1212 PFWKLITRIIKQPTKETIECQRPKPIVLATGEMRSPYDFTPSIIEIQLLKIGNFIICVVP 1391
            PFW L+  +IK+PT+    C  PKPI+L TGE+  PY + P I++ Q+L+IG F+I  VP
Sbjct: 357  PFWNLVRDLIKEPTENQKRCHFPKPILLDTGEISLPYFWQPQIVDNQILRIGQFVIIAVP 416

Query: 1392 GEFTTMSGRRLTKTVKNILMKKGVIDENGIVVVSGPSNSYTHYITTPEEYLVQRYEGGST 1571
            GEFTTMSGRR+   V   L  +G    +   V++G +N Y  YI T EEY  QRYE  ST
Sbjct: 417  GEFTTMSGRRMRDNVYLALTSQG-FPADTKTVIAGLANEYADYIATYEEYQQQRYEAAST 475

Query: 1572 IYGPNTLNAYLQLYTDLSIALADNLYVPIGPEAPDFTDKALNFVLPVIVDIPPLFKKFGD 1751
            I+GP+TL AYLQ +  L+I +A     P GP  P+  DK ++ +  VI D  P   +FG 
Sbjct: 476  IFGPHTLEAYLQTFRSLAIQMAQGQPSPPGPTPPNQLDKQISLLPGVIFDSAPSGTQFGS 535

Query: 1752 VTKDANKKYIRGETVEVEFVGGHPKNRIQLEGSFLYVQRLENNNNWINFKNDGDITTQFK 1931
            V KDA   Y  G TV V FV  +P+N ++   +FL V+  EN +NW+    D +  T+FK
Sbjct: 536  VVKDAESTYTAGSTVTVTFVSANPRNDLRTGDTFLTVEHKENGDNWVVLYADANWETRFK 595

Query: 1932 W------LGNSIVRITWEIGDDVEAGTYRIFYQGHHKQLGGKIVPEFGTT 2063
            W      LG+S   I WEI  D   G YRI + G  K + G   P  G T
Sbjct: 596  WVQTSLILGHSQAEIMWEIPKDQIPGVYRIRHFGTSKSIIGSKTPFVGQT 645