BLASTX nr result
ID: Lithospermum23_contig00010479
seq
BLASTX 2.2.26 [Sep-21-2011]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Lithospermum23_contig00010479
(1072 letters)
Database: ./nr
115,041,592 sequences; 42,171,959,267 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
XP_009785867.1 PREDICTED: interferon-induced, double-stranded RN... 174 1e-48
XP_016514778.1 PREDICTED: eIF-2-alpha kinase GCN2-like [Nicotian... 166 1e-45
1ZYC_A Chain A, Crystal Structure Of Eif2alpha Protein Kinase Gc... 151 1e-39
1ZY4_A Chain A, Crystal Structure Of Eif2alpha Protein Kinase Gc... 149 6e-39
OIR57272.1 PEK/GCN2 protein kinase [Amphiamblys sp. WSBS2006] 154 1e-37
1ZXE_A Chain A, Crystal Structure Of Eif2alpha Protein Kinase Gc... 142 3e-36
XP_005704407.1 ATP-dependent RNA helicase [Galdieria sulphuraria... 144 2e-34
XP_005795276.2 PREDICTED: interferon-induced, double-stranded RN... 142 3e-34
XP_012412144.1 PREDICTED: interferon-induced, double-stranded RN... 142 3e-34
XP_016042721.1 PREDICTED: interferon-induced, double-stranded RN... 141 5e-34
XP_011032919.1 PREDICTED: eukaryotic translation initiation fact... 137 8e-34
NP_001075682.1 interferon-induced, double-stranded RNA-activated... 139 2e-33
XP_011032918.1 PREDICTED: eukaryotic translation initiation fact... 137 2e-33
XP_014305485.1 PREDICTED: interferon-induced, double-stranded RN... 135 3e-33
ALS03806.1 interferon-induced double-stranded RNA-activated prot... 139 3e-33
XP_014393904.1 PREDICTED: interferon-induced, double-stranded RN... 139 3e-33
XP_010594172.1 PREDICTED: interferon-induced, double-stranded RN... 139 4e-33
XP_006215625.1 PREDICTED: interferon-induced, double-stranded RN... 138 5e-33
XP_006379453.1 hypothetical protein POPTR_0008s01680g [Populus t... 135 6e-33
XP_010965955.1 PREDICTED: interferon-induced, double-stranded RN... 138 6e-33
>XP_009785867.1 PREDICTED: interferon-induced, double-stranded RNA-activated
protein kinase-like [Nicotiana sylvestris]
Length = 272
Score = 174 bits (440), Expect = 1e-48
Identities = 104/275 (37%), Positives = 147/275 (53%), Gaps = 3/275 (1%)
Frame = +1
Query: 133 TRYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEHREKTLREVLALRMSQH 312
TRY D++ +GKG FGRV+ C HKLD+ Y +K +PF ++ + LREV L QH
Sbjct: 3 TRYTVDFQEIRRLGKGGFGRVYECKHKLDESTYAVKKIPFPDQEHAEYLREVKILAALQH 62
Query: 313 KNVVRYYQCWIEXXXXXXXXXXXXXXPPEKEIKDATLFIAMEHCPRTLKDILPLPLENEK 492
+V+RYYQCWIE K TLF+AME C TL L +E
Sbjct: 63 PSVIRYYQCWIELGVSDVGSSSDEDEMMSKATH--TLFVAMELCTSTLHARLEAKIEKVP 120
Query: 493 IHQFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGFAAISNSREWGVNGSS 672
+ ++ K+LLEGL IHE GV+H D+ DN+F+D ++KIGDFG A + +
Sbjct: 121 VFRYLKELLEGLQFIHEKGVIHGDLSRDNIFLDDHDHIKIGDFGLARNTGDDSIPIGDGL 180
Query: 673 SKGGDPVYEAPELKSNLN-FSENVDTYSFGLVLLEMLSAPITTVFEKTELFQK-ARSGIL 846
G+ +Y APEL + S D +S GLVL E LS P+ T +E+ F++ +SG +
Sbjct: 181 ---GNMMYRAPELSIDPRLISTKSDMFSLGLVLFE-LSCPLATGYERARQFEELKKSGEI 236
Query: 847 P-DVEDEKLGPVLRALLEVDPNCRLTPKTILSCLF 948
P + DE ++ LL+ DP R + +L F
Sbjct: 237 PEETVDETSREIICQLLKKDPQQRPSAAQLLHRYF 271
>XP_016514778.1 PREDICTED: eIF-2-alpha kinase GCN2-like [Nicotiana tabacum]
XP_016514779.1 PREDICTED: eIF-2-alpha kinase GCN2-like
[Nicotiana tabacum] XP_016514780.1 PREDICTED:
eIF-2-alpha kinase GCN2-like [Nicotiana tabacum]
XP_016514781.1 PREDICTED: eIF-2-alpha kinase GCN2-like
[Nicotiana tabacum]
Length = 265
Score = 166 bits (420), Expect = 1e-45
Identities = 103/276 (37%), Positives = 147/276 (53%), Gaps = 4/276 (1%)
Frame = +1
Query: 133 TRYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEHREKTLREVLALRMSQH 312
TRY D++ +GKG FGRV+ C HKLD+ Y +K +PF ++ + LREV L QH
Sbjct: 3 TRYTVDFQEIRRLGKGGFGRVYECKHKLDESTYAVKKIPFPDQEHAEYLREVKILAALQH 62
Query: 313 KNVVRYYQCWIEXXXXXXXXXXXXXXPPEKEIKDA--TLFIAMEHCPRTLKDILPLPLEN 486
+V+RYYQCWIE ++ + +A TLF+AME C TL L +E
Sbjct: 63 PSVIRYYQCWIE----LGVSDVGSSSDEDEMMSEATHTLFVAMELCTSTLHARLEAKIEK 118
Query: 487 EKIHQFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGFAAISNSREWGVNG 666
+ ++ K+LLEGL IHE GV+H D+ DN+F+D ++KIGDFG A + +
Sbjct: 119 VPVFRYLKELLEGLQFIHEKGVIHGDLSRDNIFLDDHDHIKIGDFGLARNTGDDSIPIGD 178
Query: 667 SSSKGGDPVYEAPELKSNLN-FSENVDTYSFGLVLLEMLSAPITTVFEKTELFQKARSGI 843
G+ +Y APEL + S D +S GLVL E LS P+ T +E +AR
Sbjct: 179 GL---GNMMYRAPELSIDPRLISTKSDMFSLGLVLFE-LSCPLATGYE------RARQCE 228
Query: 844 LP-DVEDEKLGPVLRALLEVDPNCRLTPKTILSCLF 948
+P + DE ++ LL+ DP R + +L F
Sbjct: 229 IPEETVDETSREIICQLLKKDPQQRPSAAQLLHRYF 264
>1ZYC_A Chain A, Crystal Structure Of Eif2alpha Protein Kinase Gcn2: Wild-
Type In Apo Form. 1ZYC_B Chain B, Crystal Structure Of
Eif2alpha Protein Kinase Gcn2: Wild- Type In Apo Form.
1ZYC_C Chain C, Crystal Structure Of Eif2alpha Protein
Kinase Gcn2: Wild- Type In Apo Form. 1ZYC_D Chain D,
Crystal Structure Of Eif2alpha Protein Kinase Gcn2:
Wild- Type In Apo Form. 1ZYD_A Chain A, Crystal
Structure Of Eif2alpha Protein Kinase Gcn2: Wild- Type
Complexed With Atp. 1ZYD_B Chain B, Crystal Structure Of
Eif2alpha Protein Kinase Gcn2: Wild- Type Complexed With
Atp.
Length = 303
Score = 151 bits (382), Expect = 1e-39
Identities = 102/290 (35%), Positives = 152/290 (52%), Gaps = 22/290 (7%)
Frame = +1
Query: 136 RYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEHREKTLREVLALRMSQHK 315
RY +D+ +G+GAFG+V + + LD Y IK + EE L EV+ L H+
Sbjct: 3 RYASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQ 62
Query: 316 NVVRYYQCWIEXXXXXXXXXXXXXXPPEKEIKDATLFIAMEHCP-RTLKDILP---LPLE 483
VVRYY W+E P K +TLFI ME+C RTL D++ L +
Sbjct: 63 YVVRYYAAWLERRNFVK--------PMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQ 114
Query: 484 NEKIHQFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGFAA-------ISN 642
++ + +Q+LE LS+IH G++H D+KP N+FID S N+KIGDFG A I
Sbjct: 115 RDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILK 174
Query: 643 SREWGVNGSS----SKGGDPVYEAPE-LKSNLNFSENVDTYSFGLVLLEMLSAPITTVFE 807
+ GSS S G +Y A E L +++E +D YS G++ EM+ P +T E
Sbjct: 175 LDSQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI-YPFSTGME 233
Query: 808 KTELFQKARSGIL---PDVEDEKL---GPVLRALLEVDPNCRLTPKTILS 939
+ + +K RS + PD +D K+ ++R L++ DPN R +T+L+
Sbjct: 234 RVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLN 283
>1ZY4_A Chain A, Crystal Structure Of Eif2alpha Protein Kinase Gcn2: R794g
Hyperactivating Mutant In Apo Form. 1ZY4_B Chain B,
Crystal Structure Of Eif2alpha Protein Kinase Gcn2:
R794g Hyperactivating Mutant In Apo Form. 1ZY5_A Chain
A, Crystal Structure Of Eif2alpha Protein Kinase Gcn2:
R794g Hyperactivating Mutant Complexed With Amppnp.
1ZY5_B Chain B, Crystal Structure Of Eif2alpha Protein
Kinase Gcn2: R794g Hyperactivating Mutant Complexed With
Amppnp.
Length = 303
Score = 149 bits (377), Expect = 6e-39
Identities = 101/290 (34%), Positives = 151/290 (52%), Gaps = 22/290 (7%)
Frame = +1
Query: 136 RYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEHREKTLREVLALRMSQHK 315
RY +D+ +G+GAFG+V + + LD Y IK + EE L EV+ L H+
Sbjct: 3 RYASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQ 62
Query: 316 NVVRYYQCWIEXXXXXXXXXXXXXXPPEKEIKDATLFIAMEHCPR-TLKDILP---LPLE 483
VVRYY W+E P K +TLFI ME+C TL D++ L +
Sbjct: 63 YVVRYYAAWLERRNFVK--------PMTAVKKKSTLFIQMEYCENGTLYDLIHSENLNQQ 114
Query: 484 NEKIHQFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGFAA-------ISN 642
++ + +Q+LE LS+IH G++H D+KP N+FID S N+KIGDFG A I
Sbjct: 115 RDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILK 174
Query: 643 SREWGVNGSS----SKGGDPVYEAPE-LKSNLNFSENVDTYSFGLVLLEMLSAPITTVFE 807
+ GSS S G +Y A E L +++E +D YS G++ EM+ P +T E
Sbjct: 175 LDSQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI-YPFSTGME 233
Query: 808 KTELFQKARSGIL---PDVEDEKL---GPVLRALLEVDPNCRLTPKTILS 939
+ + +K RS + PD +D K+ ++R L++ DPN R +T+L+
Sbjct: 234 RVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLN 283
>OIR57272.1 PEK/GCN2 protein kinase [Amphiamblys sp. WSBS2006]
Length = 1177
Score = 154 bits (389), Expect = 1e-37
Identities = 102/288 (35%), Positives = 156/288 (54%), Gaps = 20/288 (6%)
Frame = +1
Query: 133 TRYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEHREKT---LREVLALRM 303
+R D V G +G+G FG+VF+ +KLD Y IK VP + + ++ L+EV+AL
Sbjct: 458 SRLTTDNEVLGVLGRGGFGKVFKARNKLDGMVYAIKQVPLHTKRNKQIPNILKEVVALSQ 517
Query: 304 SQHKNVVRYYQCWIEXXXXXXXXXXXXXXPPEKEIKD-----------ATLFIAMEHCP- 447
H+N+VRY+Q WIE E + D A L+I ME+CP
Sbjct: 518 FNHENIVRYHQAWIEEGEPSAGGTETSET--ESSLSDTSEDTDAFPLSACLYIQMEYCPN 575
Query: 448 RTLKD-ILPLPLENEKIHQFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFG 624
+ L+D I L + + + +LEGL++IHE+GVVH D+ P N+F D KIGDFG
Sbjct: 576 KMLRDRIDECSLTKKDAWRILRDILEGLAYIHESGVVHRDLTPRNIFFDIHDKAKIGDFG 635
Query: 625 FAAISNSREW-GVNGSSSKGGDPVYEAP-ELKSNLNFSENVDTYSFGLVLLEMLSAPITT 798
A++++S+ W GV+ SSS+ G +Y +P E+ L+ + D YS G++ LEM + P T
Sbjct: 636 LASLADSQWWTGVSPSSSEQGTSLYTSPEEIAGVLHNKKKCDMYSLGIIFLEMCTQP-KT 694
Query: 799 VFEKTELFQKAR--SGILPDVEDEKLGPVLRALLEVDPNCRLTPKTIL 936
E+ + +KAR + +LP+ +K VL LL + R + +L
Sbjct: 695 GMERVAIIKKARLATPVLPETLGKKQKEVLENLLSHNEVARYSANGLL 742
>1ZXE_A Chain A, Crystal Structure Of Eif2alpha Protein Kinase Gcn2: D835n
Inactivating Mutant In Apo Form 1ZXE_B Chain B, Crystal
Structure Of Eif2alpha Protein Kinase Gcn2: D835n
Inactivating Mutant In Apo Form 1ZXE_C Chain C, Crystal
Structure Of Eif2alpha Protein Kinase Gcn2: D835n
Inactivating Mutant In Apo Form 1ZXE_D Chain D, Crystal
Structure Of Eif2alpha Protein Kinase Gcn2: D835n
Inactivating Mutant In Apo Form 1ZXE_E Chain E, Crystal
Structure Of Eif2alpha Protein Kinase Gcn2: D835n
Inactivating Mutant In Apo Form 1ZXE_F Chain F, Crystal
Structure Of Eif2alpha Protein Kinase Gcn2: D835n
Inactivating Mutant In Apo Form
Length = 303
Score = 142 bits (359), Expect = 3e-36
Identities = 99/290 (34%), Positives = 147/290 (50%), Gaps = 22/290 (7%)
Frame = +1
Query: 136 RYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEHREKTLREVLALRMSQHK 315
RY +D+ +G+GAFG+V + + LD Y IK + EE L EV L H+
Sbjct: 3 RYASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVXLLASLNHQ 62
Query: 316 NVVRYYQCWIEXXXXXXXXXXXXXXPPEKEIKDATLFIAMEHCP-RTLKDILP---LPLE 483
VVRYY W+E P K +TLFI E+C RTL D++ L +
Sbjct: 63 YVVRYYAAWLERRNFVK--------PXTAVKKKSTLFIQXEYCENRTLYDLIHSENLNQQ 114
Query: 484 NEKIHQFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGFAA-------ISN 642
++ + +Q+LE LS+IH G++H ++KP N+FID S N+KIGDFG A I
Sbjct: 115 RDEYWRLFRQILEALSYIHSQGIIHRNLKPXNIFIDESRNVKIGDFGLAKNVHRSLDILK 174
Query: 643 SREWGVNGSS----SKGGDPVYEAPE-LKSNLNFSENVDTYSFGLVLLEMLSAPITTVFE 807
+ GSS S G Y A E L +++E +D YS G++ E + P +T E
Sbjct: 175 LDSQNLPGSSDNLTSAIGTAXYVATEVLDGTGHYNEKIDXYSLGIIFFEXI-YPFSTGXE 233
Query: 808 KTELFQKARSGIL---PDVEDEKL---GPVLRALLEVDPNCRLTPKTILS 939
+ + +K RS + PD +D K ++R L++ DPN R +T+L+
Sbjct: 234 RVNILKKLRSVSIEFPPDFDDNKXKVEKKIIRLLIDHDPNKRPGARTLLN 283
>XP_005704407.1 ATP-dependent RNA helicase [Galdieria sulphuraria] EME27887.1
ATP-dependent RNA helicase [Galdieria sulphuraria]
Length = 1885
Score = 144 bits (364), Expect = 2e-34
Identities = 93/294 (31%), Positives = 140/294 (47%), Gaps = 33/294 (11%)
Frame = +1
Query: 133 TRYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEE--HREKTLREVLALRMS 306
+RY D+ +G+G FG V + +KLD Y +K V EE LREV L
Sbjct: 981 SRYREDFEYLRLLGRGGFGSVMKVRNKLDGRIYALKRVALTEELLQERHILREVTTLSRL 1040
Query: 307 QHKNVVRYYQCWIEXXXXXXXXXXXXXXPPEKEIKDATLFIAMEHCPRTLKDILPLPLE- 483
H +VVRY+ W+E P ++ A L+I ME+C RTL++ + ++
Sbjct: 1041 SHPHVVRYHHAWLEYNESLESSSEQEESPESAKVV-AYLYIQMEYCRRTLREFIDHVVDK 1099
Query: 484 NEKIHQFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGFAAISNSREWGVN 663
NE + +Q++EGL HIH G++H D+KP N+F D G +KIGDFG A ++E ++
Sbjct: 1100 NEDLWGLFRQIVEGLHHIHHCGILHRDLKPTNIFFDAQGTIKIGDFGLAKEIVTQEGVLS 1159
Query: 664 GSSSKGGDPV------------------------YEAPELKSN--LNFSENVDTYSFGLV 765
S + D V Y APEL+ N + VD YS G++
Sbjct: 1160 SSDRRYADHVSLSGNLISNDSFGNDRTGGVGTLYYRAPELEENEFPTYDSKVDIYSLGII 1219
Query: 766 LLEMLSAPITTVFEKTELFQKARSGILPDVED----EKLGPVLRALLEVDPNCR 915
E+ P T E+ E+ + R PD + ++ G ++R+LL DP R
Sbjct: 1220 AFELWHGPFETAMERHEVLMRLRETGSPDSDFQGRLQRQGKLIRSLLMKDPKKR 1273
>XP_005795276.2 PREDICTED: interferon-induced, double-stranded RNA-activated protein
kinase-like [Xiphophorus maculatus]
Length = 572
Score = 142 bits (358), Expect = 3e-34
Identities = 97/276 (35%), Positives = 143/276 (51%), Gaps = 17/276 (6%)
Frame = +1
Query: 139 YMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEHREKTLREVLALRMSQHKN 318
+ +D+ + +G G FGRVF T KL +Y +K+VP E K LREV+AL QH+N
Sbjct: 291 FASDFEILEYLGGGGFGRVFMVTEKLLDLDYAVKVVPGTE----KALREVMALSDLQHEN 346
Query: 319 VVRYYQCWIEXXXXXXXXXXXXXXPPEKEIKDAT----LFIAMEHC-PRTLKDILPLPLE 483
+VRYY CW+E +K++KD T LFI ME C P TLK + E
Sbjct: 347 IVRYYNCWMEDLKVQPAKV-------QKKLKDVTCGQCLFIKMELCKPATLKQWIGERNE 399
Query: 484 NEKIHQ--------FSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGFAAIS 639
E H + Q++ G+ +IH N +H D+KP N+ +G +KIGDFG I
Sbjct: 400 EELSHPQRGADSLPIALQIVNGVEYIHSNNFIHRDLKPPNIMFGKNGKVKIGDFGLVTID 459
Query: 640 NSREWGVNGSSSKGGDPVYEAPELKSNLNFSENVDTYSFGLVLLEMLSAPITTVFEKTEL 819
S + + G +Y APE +SN + VD +S GL+ E+L ++T E+ +
Sbjct: 460 RSEI--LIDRTEGPGTKIYMAPEQESN-RYDRKVDMFSLGLIFFELL-WKMSTGHERATI 515
Query: 820 FQKARSGILPDVEDEKLGP----VLRALLEVDPNCR 915
++ AR G LP E + P ++++LL +PN R
Sbjct: 516 WKNARKGKLPK-EFSQAFPFEYRIIKSLLSENPNDR 550
>XP_012412144.1 PREDICTED: interferon-induced, double-stranded RNA-activated protein
kinase [Trichechus manatus latirostris]
Length = 548
Score = 142 bits (357), Expect = 3e-34
Identities = 95/284 (33%), Positives = 140/284 (49%), Gaps = 13/284 (4%)
Frame = +1
Query: 133 TRYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEHREKTLREVLALRMSQH 312
+R++ D+ IG G +G+VF+ H++DK YVIK V ++ E K REV AL H
Sbjct: 272 SRFVKDFEEIEPIGTGGYGQVFKAKHRIDKKTYVIKRVKYDNE---KVEREVKALASLNH 328
Query: 313 KNVVRYYQCWIEXXXXXXXXXXXXXXPPEKEIKDAT-----LFIAMEHCPRTLKDILPLP 477
N+V Y+ CW PE I + LFI ME C K L
Sbjct: 329 VNIVHYHNCWA-----------GDDYDPEISINKSRSMTKCLFIQMEFCD---KGTLEQW 374
Query: 478 LENEKIHQFSK--------QLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGFAA 633
++N + + K Q+ +G+++IH ++H D+KP N+F+ H+ +KIGDFG
Sbjct: 375 IDNRRDKKSDKDLALDLFEQITKGVAYIHSKRLIHRDLKPSNIFLVHTKQVKIGDFGLVT 434
Query: 634 ISNSREWGVNGSSSKGGDPVYEAPELKSNLNFSENVDTYSFGLVLLEMLSAPITTVFEKT 813
+ E + + G +Y +PE S+ + VD ++ GL+L E+L TTV E
Sbjct: 435 TLKNDE----KRTVEKGTLLYMSPEQMSSPEYGNEVDIFTLGLILAELLHV-CTTVQETV 489
Query: 814 ELFQKARSGILPDVEDEKLGPVLRALLEVDPNCRLTPKTILSCL 945
++F K R G PDV D K +L+ LL DP RL IL L
Sbjct: 490 KIFGKLRKGFFPDVFDPKEKNLLQKLLAKDPKKRLPAPEILKTL 533
>XP_016042721.1 PREDICTED: interferon-induced, double-stranded RNA-activated protein
kinase [Erinaceus europaeus] XP_016042722.1 PREDICTED:
interferon-induced, double-stranded RNA-activated protein
kinase [Erinaceus europaeus]
Length = 530
Score = 141 bits (355), Expect = 5e-34
Identities = 94/277 (33%), Positives = 138/277 (49%), Gaps = 7/277 (2%)
Frame = +1
Query: 136 RYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEHREKTLREVLALRMSQHK 315
R++ D+R I G FG+VF+ H++D Y IK V ++ REK REV AL H
Sbjct: 257 RFLKDFRDITPIASGGFGQVFKARHRIDTKIYAIKRVKYD---REKVEREVKALANLSHS 313
Query: 316 NVVRYYQCWIEXXXXXXXXXXXXXXPPEKEIKDAT--LFIAMEHCPRTLKDILPLPLENE 489
N+V YY CW K +++ T LFI ME+C + D +N
Sbjct: 314 NIVHYYDCW---------GGNDYYEDSMKNLRNLTRCLFIKMEYCDKGTLDDWIFKRKNS 364
Query: 490 KIH----QFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGFAAISNSREWG 657
+F +Q+ EG+ +IH +H D+KP N+F+ +KIGDFG +
Sbjct: 365 SQKDLALEFFRQITEGVHYIHSKEFIHRDLKPSNIFLVDEKQIKIGDFGLVTALKT---- 420
Query: 658 VNGS-SSKGGDPVYEAPELKSNLNFSENVDTYSFGLVLLEMLSAPITTVFEKTELFQKAR 834
NG ++ G P Y +PE S++N+ VD ++ GL+L E+L TT E +LF K R
Sbjct: 421 -NGKLTANLGTPQYMSPEQLSSVNYDNKVDIFALGLILAELLYVCGTTC-ETIKLFDKLR 478
Query: 835 SGILPDVEDEKLGPVLRALLEVDPNCRLTPKTILSCL 945
+GI PD D+ +L+ LL +P+ R T L L
Sbjct: 479 AGIFPDEFDKNEKSLLQKLLFHEPSKRPTAFETLQTL 515
>XP_011032919.1 PREDICTED: eukaryotic translation initiation factor 2-alpha kinase
3-like isoform X2 [Populus euphratica]
Length = 333
Score = 137 bits (344), Expect = 8e-34
Identities = 91/278 (32%), Positives = 136/278 (48%), Gaps = 9/278 (3%)
Frame = +1
Query: 133 TRYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEH-REKTLREVLALRMSQ 309
TR+ ++ IGKGA+G VF C HKLD Y +K+V FN+ + ++K LREV AL
Sbjct: 4 TRFHQEFYKIERIGKGAYGTVFSCMHKLDGQAYAVKIVKFNKHNDQDKVLREVKALAKCN 63
Query: 310 HKNVVRYYQCWIEXXXXXXXXXXXXXXP------PEKEIKDATLFIAMEHCPRTLKDILP 471
H NVVRY+ WIE + DA LFI MEHC + L ++L
Sbjct: 64 HSNVVRYFNAWIEWMVVRSSDEDEDYDKGGGGDGSSPKSPDAMLFIQMEHCHQNLDNLLE 123
Query: 472 LPLENE-KIHQFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGFAAISNSR 648
E ++ + +++GL HIH ++H D+ N+FID S +K+ DFG A + +
Sbjct: 124 QSTITEGTALRYFQGMVKGLDHIHGKKIIHGDLSRKNIFIDASDVIKVADFGLAKLLGNS 183
Query: 649 EWGVNGSSSKGGDPVYEAPELKSNLNFSENVDTYSFGLVLLEMLSAPITTVFEKTELFQK 828
+ SS G Y APE + + D YS G++ LE+L + TT+ +
Sbjct: 184 ATAIKSGSS--GTKFYLAPEAEKGAPIDQKADIYSLGILFLELLGS-FTTMSARAHAIND 240
Query: 829 ARS-GILPDVEDEKLGPVLRALLEVDPNCRLTPKTILS 939
R +LP+ +L+ L+ P R + K IL+
Sbjct: 241 LREMRVLPESISTYEDYILQ-LVAFSPEERPSTKEILT 277
>NP_001075682.1 interferon-induced, double-stranded RNA-activated protein kinase
[Oryctolagus cuniculus] AAZ23127.1 eukaryotic translation
initiation factor 2-alpha kinase 2 [Oryctolagus
cuniculus]
Length = 547
Score = 139 bits (351), Expect = 2e-33
Identities = 93/278 (33%), Positives = 137/278 (49%), Gaps = 8/278 (2%)
Frame = +1
Query: 136 RYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEHREKTLREVLALRMSQHK 315
R+ D++ IG G FG+VF+ H++D YVIK V ++ E K REV AL H
Sbjct: 264 RFANDFKEIEPIGAGGFGQVFKAKHRIDGKTYVIKRVKYDSE---KVEREVKALAALTHP 320
Query: 316 NVVRYYQCWIEXXXXXXXXXXXXXXPPEKE--IKDATLFIAMEHCPRTLKDILPLPLENE 489
N+V YY CW+ +K L I ME C D ++
Sbjct: 321 NIVHYYGCWVGHDYDPESSNSDTENSMNMNLGVKTRCLLIQMEFCDLGTLDQWIETRSHQ 380
Query: 490 KIH-----QFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGF-AAISNSRE 651
K +F Q+ GL +IH ++H D+KP+N+F+ +KIGDFG ++ N+ +
Sbjct: 381 KSEKALALEFFWQITTGLKYIHSKELIHRDLKPNNIFLVAINQIKIGDFGLVTSLQNNEK 440
Query: 652 WGVNGSSSKGGDPVYEAPELKSNLNFSENVDTYSFGLVLLEMLSAPITTVFEKTELFQKA 831
VN + + Y +PE S+ N+ + VD Y+ GL+L E+L TTV E ++F +
Sbjct: 441 RTVNKGTLR-----YMSPEQISSQNYGKEVDIYALGLILAELLHI-CTTVVETAKIFAEL 494
Query: 832 RSGILPDVEDEKLGPVLRALLEVDPNCRLTPKTILSCL 945
R GI PDV D K +L+ LL ++P R IL L
Sbjct: 495 RRGIFPDVFDIKEKTLLQKLLALEPEKRPDTSEILKTL 532
>XP_011032918.1 PREDICTED: eukaryotic translation initiation factor 2-alpha kinase
3-like isoform X1 [Populus euphratica]
Length = 388
Score = 137 bits (344), Expect = 2e-33
Identities = 91/278 (32%), Positives = 136/278 (48%), Gaps = 9/278 (3%)
Frame = +1
Query: 133 TRYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEH-REKTLREVLALRMSQ 309
TR+ ++ IGKGA+G VF C HKLD Y +K+V FN+ + ++K LREV AL
Sbjct: 59 TRFHQEFYKIERIGKGAYGTVFSCMHKLDGQAYAVKIVKFNKHNDQDKVLREVKALAKCN 118
Query: 310 HKNVVRYYQCWIEXXXXXXXXXXXXXXP------PEKEIKDATLFIAMEHCPRTLKDILP 471
H NVVRY+ WIE + DA LFI MEHC + L ++L
Sbjct: 119 HSNVVRYFNAWIEWMVVRSSDEDEDYDKGGGGDGSSPKSPDAMLFIQMEHCHQNLDNLLE 178
Query: 472 LPLENE-KIHQFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGFAAISNSR 648
E ++ + +++GL HIH ++H D+ N+FID S +K+ DFG A + +
Sbjct: 179 QSTITEGTALRYFQGMVKGLDHIHGKKIIHGDLSRKNIFIDASDVIKVADFGLAKLLGNS 238
Query: 649 EWGVNGSSSKGGDPVYEAPELKSNLNFSENVDTYSFGLVLLEMLSAPITTVFEKTELFQK 828
+ SS G Y APE + + D YS G++ LE+L + TT+ +
Sbjct: 239 ATAIKSGSS--GTKFYLAPEAEKGAPIDQKADIYSLGILFLELLGS-FTTMSARAHAIND 295
Query: 829 ARS-GILPDVEDEKLGPVLRALLEVDPNCRLTPKTILS 939
R +LP+ +L+ L+ P R + K IL+
Sbjct: 296 LREMRVLPESISTYEDYILQ-LVAFSPEERPSTKEILT 332
>XP_014305485.1 PREDICTED: interferon-induced, double-stranded RNA-activated
protein kinase-like [Myotis lucifugus]
Length = 315
Score = 135 bits (339), Expect = 3e-33
Identities = 87/275 (31%), Positives = 138/275 (50%), Gaps = 6/275 (2%)
Frame = +1
Query: 139 YMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEHREKTLREVLALRMSQHKN 318
++ D+ IG GA+G VF+ H+LD YVIK V +N E K REV AL M H N
Sbjct: 48 FLKDFEEIAPIGSGAYGSVFKAKHRLDGTTYVIKCVKYNNE---KVKREVKALAMLSHPN 104
Query: 319 VVRYYQCWIEXXXXXXXXXXXXXXPPEKEIKDATLFIAMEHCPR-TLKDILPL-----PL 480
+VRYY W+ K LFI ME C + TL+ + + P
Sbjct: 105 IVRYYNSWVGEDY-------------NKRSLPKYLFIQMEFCEKGTLEAWIEIRRGEIPN 151
Query: 481 ENEKIHQFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGFAAISNSREWGV 660
++ + F KQ++ G+ +IH G++H D+KP N+F+ + +KIGDFG +
Sbjct: 152 KDLSLGLF-KQIVTGVDYIHSEGLIHRDLKPSNIFLVDTKQIKIGDFGLVTFQKHDK--- 207
Query: 661 NGSSSKGGDPVYEAPELKSNLNFSENVDTYSFGLVLLEMLSAPITTVFEKTELFQKARSG 840
+ G +Y +PE +++ + VD ++ GL+L E+L P++ E ++F+ R G
Sbjct: 208 -QRTEDQGTRLYMSPEQLASVEYGNEVDIFALGLILSELLYIPLSRQ-ETYKIFEDLRKG 265
Query: 841 ILPDVEDEKLGPVLRALLEVDPNCRLTPKTILSCL 945
+ D+ ++K +L+ L+ DP R IL L
Sbjct: 266 HVSDIFNDKEKILLQKLVATDPKMRPKTSEILKTL 300
>ALS03806.1 interferon-induced double-stranded RNA-activated protein kinase
[Oryctolagus cuniculus]
Length = 547
Score = 139 bits (350), Expect = 3e-33
Identities = 92/278 (33%), Positives = 138/278 (49%), Gaps = 8/278 (2%)
Frame = +1
Query: 136 RYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEHREKTLREVLALRMSQHK 315
R+ D++ IG G FG+VF+ H++D YVIK V ++ E K REV AL H
Sbjct: 264 RFANDFKEIEPIGAGGFGQVFKAKHRIDGKTYVIKRVKYDSE---KVEREVKALAALTHP 320
Query: 316 NVVRYYQCWIEXXXXXXXXXXXXXXPPEKE--IKDATLFIAMEHCP-----RTLKDILPL 474
N+V YY CW+ +K L I ME C + +++
Sbjct: 321 NIVHYYGCWVGHDYDPESSNSDTENSMNMNLGVKTRCLLIQMEFCDLGTLEQWIENRRQQ 380
Query: 475 PLENEKIHQFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGF-AAISNSRE 651
E +F Q+ GL +IH ++H D+KP+N+F+ +KIGDFG ++ N+ +
Sbjct: 381 KSEKALALEFFWQITTGLKYIHSKELIHRDLKPNNIFLVAINQIKIGDFGLVTSLQNNEK 440
Query: 652 WGVNGSSSKGGDPVYEAPELKSNLNFSENVDTYSFGLVLLEMLSAPITTVFEKTELFQKA 831
VN + + Y +PE S+ N+ + VD Y+ GL+L E+L TTV E ++F +
Sbjct: 441 RTVNKGTLR-----YMSPEQISSQNYGKEVDIYALGLILAELLHI-CTTVVETAKIFAEL 494
Query: 832 RSGILPDVEDEKLGPVLRALLEVDPNCRLTPKTILSCL 945
R GI PDV D K +L+ LL ++P R IL L
Sbjct: 495 RRGIFPDVFDIKEKTLLQKLLALEPEKRPDTSEILKTL 532
>XP_014393904.1 PREDICTED: interferon-induced, double-stranded RNA-activated protein
kinase isoform X1 [Myotis brandtii]
Length = 527
Score = 139 bits (349), Expect = 3e-33
Identities = 89/276 (32%), Positives = 140/276 (50%), Gaps = 6/276 (2%)
Frame = +1
Query: 136 RYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEHREKTLREVLALRMSQHK 315
R++ D+ IG GA+G +F+ H++D YVIK V +N E K REV L H
Sbjct: 259 RFINDFEEIAPIGSGAYGSIFKAKHRIDGTTYVIKRVKYNNE---KVKREVKVLATLSHP 315
Query: 316 NVVRYYQCWIEXXXXXXXXXXXXXXPPEKEIKDATLFIAMEHCPR-TLKDILP-----LP 477
N+VRYY CW E+ +K LFI ME C + TL+D + +P
Sbjct: 316 NIVRYYNCWDGDDYN------------ERSLKKC-LFIQMEFCDQGTLEDWIENRREKIP 362
Query: 478 LENEKIHQFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGFAAISNSREWG 657
++ + F KQ++ G+ +IH G++H D+KP N+F+ + +KIGDFG +
Sbjct: 363 NKDLSLGLF-KQIVTGVDYIHSKGLIHRDLKPSNIFLVDTKQIKIGDFGLVTFQKHDK-- 419
Query: 658 VNGSSSKGGDPVYEAPELKSNLNFSENVDTYSFGLVLLEMLSAPITTVFEKTELFQKARS 837
+ G P+Y +PE +++ + VD ++ GL+L E+L P T E ++F+ R
Sbjct: 420 --QRTEDRGTPLYMSPEQLASVEYGNEVDIFALGLILSELLYIPHTRQ-ETYKIFEDLRK 476
Query: 838 GILPDVEDEKLGPVLRALLEVDPNCRLTPKTILSCL 945
G + + D+K +L+ L+ DP R IL L
Sbjct: 477 GHVSAIFDDKEKILLQKLVATDPKMRPKTSEILKTL 512
>XP_010594172.1 PREDICTED: interferon-induced, double-stranded RNA-activated protein
kinase [Loxodonta africana] XP_010594173.1 PREDICTED:
interferon-induced, double-stranded RNA-activated protein
kinase [Loxodonta africana]
Length = 548
Score = 139 bits (349), Expect = 4e-33
Identities = 96/285 (33%), Positives = 139/285 (48%), Gaps = 14/285 (4%)
Frame = +1
Query: 133 TRYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEHREKTLREVLALRMSQH 312
+R++ D+ IG G +G VF+ H++DK YVIK V +N E K REV AL H
Sbjct: 272 SRFVKDFEEIEPIGSGGYGDVFKAKHRIDKKTYVIKRVKYNNE---KVEREVKALANLNH 328
Query: 313 KNVVRYYQCWIEXXXXXXXXXXXXXXPPEKEIKDAT-----LFIAMEHCPRTLKDILPLP 477
N+V Y+ CW PE ++ LFI ME C K L
Sbjct: 329 ANIVHYHYCW-----------DGYDYDPENSTNNSRSVTKCLFIQMEFCD---KGTLEQW 374
Query: 478 LENEKIHQFSK--------QLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGF-A 630
+E+ + Q K Q+ +G+++IH ++H D+KP N+F+ H +KIGDFG
Sbjct: 375 IESRRGKQSDKDLALDLFEQITKGVAYIHSQRLIHRDLKPSNIFLVHIKQVKIGDFGLVT 434
Query: 631 AISNSREWGVNGSSSKGGDPVYEAPELKSNLNFSENVDTYSFGLVLLEMLSAPITTVFEK 810
++ N + V+ + + Y +PE S + VD ++ GL+L E+L TTV E
Sbjct: 435 SLKNDEKRTVDKGTWR-----YMSPEQMSLQEYGNEVDIFALGLILAELLHI-CTTVQET 488
Query: 811 TELFQKARSGILPDVEDEKLGPVLRALLEVDPNCRLTPKTILSCL 945
++F R GI PDV D K +L+ LL DP RL IL L
Sbjct: 489 VKIFNDLRQGIFPDVFDTKEKNLLQKLLSKDPKERLKAPEILKTL 533
>XP_006215625.1 PREDICTED: interferon-induced, double-stranded RNA-activated protein
kinase [Vicugna pacos]
Length = 531
Score = 138 bits (348), Expect = 5e-33
Identities = 94/281 (33%), Positives = 144/281 (51%), Gaps = 11/281 (3%)
Frame = +1
Query: 136 RYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEHREKTLREVLALRMSQHK 315
R+++D+ IG G FG+VF+ H++DK YVIK V ++ E K REV AL H
Sbjct: 256 RFVSDFTEVEPIGSGGFGQVFKAKHRIDKKTYVIKRVKYDSE---KVEREVKALATLNHV 312
Query: 316 NVVRYYQCWIEXXXXXXXXXXXXXXPPEKEI-----KDATLFIAMEHCPR-TLKDILPL- 474
N+V Y+ CW PEK I K LFI ME+C + TL+ +
Sbjct: 313 NIVHYHSCW-----------DGYDYDPEKSINTSRSKTRCLFIQMEYCDKGTLEQWIDSR 361
Query: 475 --PLENEKIH-QFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGF-AAISN 642
N+++ +F +++ G+ +IH N ++H D+KP N+F+ + +KIGDFG ++ N
Sbjct: 362 RGKKPNKRLALEFFEKITAGVHYIHSNQLIHRDLKPSNIFLVDTNQIKIGDFGLVTSLKN 421
Query: 643 SREWGVNGSSSKGGDPVYEAPELKSNLNFSENVDTYSFGLVLLEMLSAPITTVFEKTELF 822
N +++ G Y +PE S+ ++ VD + GL+L E+L T E ++F
Sbjct: 422 D-----NMRTTEKGTKRYMSPEQDSSEDYGNEVDIFPLGLILAELLYI-CPTFSETVKMF 475
Query: 823 QKARSGILPDVEDEKLGPVLRALLEVDPNCRLTPKTILSCL 945
K R+GI DV D K +L+ LL +P R IL L
Sbjct: 476 DKLRAGIFLDVFDNKEKDLLQKLLSKEPKKRPDTSEILKTL 516
>XP_006379453.1 hypothetical protein POPTR_0008s01680g [Populus trichocarpa]
ERP57250.1 hypothetical protein POPTR_0008s01680g
[Populus trichocarpa]
Length = 350
Score = 135 bits (339), Expect = 6e-33
Identities = 93/277 (33%), Positives = 136/277 (49%), Gaps = 14/277 (5%)
Frame = +1
Query: 151 YRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEH-REKTLREVLALRMSQHKNVVR 327
Y++ G IGKGA+G VF C HKLD Y +K+V FN + ++K LREV AL H NVVR
Sbjct: 23 YKIKG-IGKGAYGTVFSCMHKLDGQAYAVKVVKFNRHNDQDKVLREVKALAKCNHSNVVR 81
Query: 328 YYQCWIEXXXXXXXXXXXXXXPPEKEIK------DATLFIAMEHCP-----RTLKDILPL 474
Y+ WIE E + DA LFI MEHC R L ++L
Sbjct: 82 YFNAWIEWMVVQSSDEDDDYDKEEGDDSASSKSLDAMLFIQMEHCHCLLFHRNLDNVLEQ 141
Query: 475 PLENEKIH-QFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGFAAISNSRE 651
E ++ + +++GL HIH ++H D+ N+FID + +K+ DFG A + +
Sbjct: 142 STITEGTALKYFQGMVKGLDHIHGKKIIHGDLSRKNIFIDANNVIKVADFGLAKLLGNSA 201
Query: 652 WGVNGSSSKGGDPVYEAPELKSNLNFSENVDTYSFGLVLLEMLSAPITTVFEKTELFQKA 831
+ SS G Y APE + + VD YS G++ LE+L + TT+ +
Sbjct: 202 TAIKSGSS--GTKSYLAPEAEKGAPIDQKVDIYSLGILFLELLGS-FTTMSARAHAINNL 258
Query: 832 RS-GILPDVEDEKLGPVLRALLEVDPNCRLTPKTILS 939
R +LP+ +L+ L+ P R + K IL+
Sbjct: 259 REMRVLPESISTYEDYILQ-LVAFSPEERPSTKEILT 294
>XP_010965955.1 PREDICTED: interferon-induced, double-stranded RNA-activated protein
kinase isoform X2 [Camelus bactrianus] XP_010997942.1
PREDICTED: interferon-induced, double-stranded
RNA-activated protein kinase isoform X2 [Camelus
dromedarius] XP_014421574.1 PREDICTED:
interferon-induced, double-stranded RNA-activated protein
kinase isoform X2 [Camelus ferus]
Length = 522
Score = 138 bits (347), Expect = 6e-33
Identities = 94/282 (33%), Positives = 144/282 (51%), Gaps = 11/282 (3%)
Frame = +1
Query: 133 TRYMADYRVNGEIGKGAFGRVFRCTHKLDKGEYVIKMVPFNEEHREKTLREVLALRMSQH 312
+R+++D+ IG G FG+VF+ H++DK YVIK V ++ EK REV AL H
Sbjct: 246 SRFVSDFTEVEPIGSGGFGQVFKAKHRIDKKTYVIKRVKYDS---EKVEREVKALATLNH 302
Query: 313 KNVVRYYQCWIEXXXXXXXXXXXXXXPPEKEI-----KDATLFIAMEHCPR-TLK---DI 465
N+V Y+ CW PEK I K LFI ME+C + TL+ D
Sbjct: 303 VNIVHYHSCW-----------DGYDYDPEKSINTSRSKTRCLFIQMEYCDKGTLEQWIDS 351
Query: 466 LPLPLENEKIH-QFSKQLLEGLSHIHENGVVHLDIKPDNLFIDHSGNLKIGDFGF-AAIS 639
N+++ +F +++ G+ +IH N ++H D+KP N+F+ + +KIGDFG ++
Sbjct: 352 RRGKKPNKRLALEFFEKITAGVHYIHSNQLIHRDLKPSNIFLVDTNQIKIGDFGLVTSLK 411
Query: 640 NSREWGVNGSSSKGGDPVYEAPELKSNLNFSENVDTYSFGLVLLEMLSAPITTVFEKTEL 819
N N +++ G Y +PE S+ ++ VD + GL+L E+L T E ++
Sbjct: 412 ND-----NMRTTEKGTKRYMSPEQDSSEDYGNEVDIFPLGLILAELLYI-CPTFLETVKM 465
Query: 820 FQKARSGILPDVEDEKLGPVLRALLEVDPNCRLTPKTILSCL 945
F+ R GI DV D K +L+ LL +P R IL L
Sbjct: 466 FENLRDGIFLDVFDNKEKDLLQKLLSKEPKKRPDTSEILKTL 507