BLASTX 2.2.25 [Feb-01-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Forsythia22_contig00028089
         (4866 letters)

Database: ./nr 
           69,698,275 sequences; 24,982,196,650 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

emb|CDP07797.1| unnamed protein product [Coffea canephora]           2045   0.0  
ref|XP_011087914.1| PREDICTED: DNA topoisomerase 2 isoform X1 [S...  2034   0.0  
ref|XP_011087923.1| PREDICTED: DNA topoisomerase 2 isoform X2 [S...  2032   0.0  
ref|XP_002274267.1| PREDICTED: DNA topoisomerase 2 [Vitis vinifera]  2020   0.0  
ref|XP_012849677.1| PREDICTED: DNA topoisomerase 2 [Erythranthe ...  2016   0.0  
ref|XP_010241214.1| PREDICTED: DNA topoisomerase 2-like isoform ...  2014   0.0  
ref|XP_010241213.1| PREDICTED: DNA topoisomerase 2-like isoform ...  2011   0.0  
ref|XP_007009327.1| DNA topoisomerase 2 isoform 1 [Theobroma cac...  1994   0.0  
ref|XP_006345427.1| PREDICTED: DNA topoisomerase 2-like [Solanum...  1979   0.0  
ref|XP_010257162.1| PREDICTED: LOW QUALITY PROTEIN: DNA topoisom...  1978   0.0  
ref|XP_009800897.1| PREDICTED: LOW QUALITY PROTEIN: DNA topoisom...  1959   0.0  
ref|XP_009630917.1| PREDICTED: LOW QUALITY PROTEIN: DNA topoisom...  1956   0.0  
ref|XP_010324649.1| PREDICTED: DNA topoisomerase 2 isoform X1 [S...  1953   0.0  
ref|XP_004229644.1| PREDICTED: DNA topoisomerase 2 isoform X2 [S...  1952   0.0  
ref|XP_012455306.1| PREDICTED: DNA topoisomerase 2 isoform X1 [G...  1949   0.0  
ref|XP_010023678.1| PREDICTED: DNA topoisomerase 2-like [Eucalyp...  1948   0.0  
dbj|BAE06274.1| topoisomerase II [Scutellaria baicalensis]           1948   0.0  
ref|XP_012455307.1| PREDICTED: DNA topoisomerase 2 isoform X2 [G...  1947   0.0  
ref|XP_008231458.1| PREDICTED: DNA topoisomerase 2 isoform X2 [P...  1939   0.0  
ref|XP_008231457.1| PREDICTED: DNA topoisomerase 2 isoform X1 [P...  1939   0.0  

>emb|CDP07797.1| unnamed protein product [Coffea canephora]
          Length = 1486

 Score = 2045 bits (5297), Expect = 0.0
 Identities = 1057/1486 (71%), Positives = 1205/1486 (81%), Gaps = 47/1486 (3%)
 Frame = -1

Query: 4767 KAPLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHNQTLW 4588
            K PL SSNNANI             KTIE+TYQKK+QLEHILLRPDTYIGSIEKH+QTLW
Sbjct: 8    KLPLQSSNNANI--------VLPTGKTIEETYQKKSQLEHILLRPDTYIGSIEKHSQTLW 59

Query: 4587 VYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVYNNGD 4408
            V+E   MV + I+YVPGLYKIFDEILVNAADNKQRDP+M+S+K+ I+ E N ISVYNNGD
Sbjct: 60   VFENDAMVHRQISYVPGLYKIFDEILVNAADNKQRDPRMDSVKIVINVEENFISVYNNGD 119

Query: 4407 GVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVIETAD 4228
            GVPVE+HQEEGVYVPELIFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEFVIE+AD
Sbjct: 120  GVPVEVHQEEGVYVPELIFGHLLTSSNYDDTVKKTTGGRNGYGAKLTNIFSTEFVIESAD 179

Query: 4227 GRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVALMKKR 4048
            GRRQ+KYKQVF+ NMGNKSQP+ISKCKESENWTKVT+KPDL+KFNMTHLEDDVVALMKKR
Sbjct: 180  GRRQKKYKQVFSNNMGNKSQPIISKCKESENWTKVTYKPDLAKFNMTHLEDDVVALMKKR 239

Query: 4047 VIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAF--------RIEEKV-DRWEVCV 3895
            V+D+AGCLGK VKVELNG+ + V+SF DYC+LYL+SA         RI EKV +RWEVC 
Sbjct: 240  VVDLAGCLGKTVKVELNGQRVPVKSFSDYCDLYLQSAAKTRPDPLPRIVEKVNERWEVCA 299

Query: 3894 SLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYVNKKRKNANLKPHSVRNHLWV 3715
            SLS+GQFQQVSFVN I+TIKGGTHVDYVTNQI  H+   VNKK KNANLK HSV+NHLWV
Sbjct: 300  SLSEGQFQQVSFVNGIATIKGGTHVDYVTNQITNHIIGIVNKKNKNANLKAHSVKNHLWV 359

Query: 3714 FVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVANSEIVNNILEWAEFKEKKD 3535
            FVN LIDNPAFDSQTKETLTLRQ SFGS+C+LS +FL KVA S +V N+L WA+FK+ KD
Sbjct: 360  FVNALIDNPAFDSQTKETLTLRQSSFGSKCELSQEFLKKVAKSGVVENLLSWADFKQSKD 419

Query: 3534 LKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGRDHYGV 3355
            LKKTDGTK +RITG+TKL DAN+AGG+NS++CTLILTEGDSA  LA+AG+SVVGR+ YGV
Sbjct: 420  LKKTDGTKRQRITGITKLEDANDAGGKNSDRCTLILTEGDSAKALAMAGISVVGRNFYGV 479

Query: 3354 FPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTDQDHDG 3175
            FPLRGKLLNVR+AS KQI DNAEIQ IK+ILGLQHGK YDS+KSLRYGHLMIMTDQDHDG
Sbjct: 480  FPLRGKLLNVREASHKQIMDNAEIQYIKQILGLQHGKVYDSVKSLRYGHLMIMTDQDHDG 539

Query: 3174 SHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKRSFYTMPEYESWKESLGD 2995
            SHIKGLLINFIHSFWPSLL+IPSFLVEFITPIVKATHKNG   SFYTMPEYESWKESL  
Sbjct: 540  SHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHKNGRVLSFYTMPEYESWKESLSG 599

Query: 2994 KARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKKKIEARKN 2815
             A  WSIKYYKGLGTST KEGKEYFKDL KHKKDF+W DDNDGEAIELAFSKKKIEARKN
Sbjct: 600  NATGWSIKYYKGLGTSTSKEGKEYFKDLGKHKKDFIWVDDNDGEAIELAFSKKKIEARKN 659

Query: 2814 WLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRKILFCAFK 2635
            WLRQFEPGTYLDQ++KLIKY DF+NKELILFS+ADLQRSIPSMVDGLKPGQRKILFC+FK
Sbjct: 660  WLRQFEPGTYLDQKEKLIKYSDFINKELILFSLADLQRSIPSMVDGLKPGQRKILFCSFK 719

Query: 2634 RNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNGQFGTRNQ 2455
            RNFV EAKV QF+GYVSEHSAYHHGEQSLAS IIGMAQ +VGSNNIN+L+PNGQFGTRNQ
Sbjct: 720  RNFVKEAKVAQFSGYVSEHSAYHHGEQSLASAIIGMAQDFVGSNNINLLQPNGQFGTRNQ 779

Query: 2454 GGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVVLVNGSEG 2275
            GGKDHASARY++T+LS ITR LFPKDDDILLDY NEDGQ+IEPTWY+PIIP+VLVNGSEG
Sbjct: 780  GGKDHASARYVYTRLSPITRSLFPKDDDILLDYLNEDGQSIEPTWYMPIIPMVLVNGSEG 839

Query: 2274 IGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAGATYTVTG 2095
            IGTGWSS++PNYNPRDII N+R +L +EPMEPM+PWYKGFRGTIEKTATKEAGA+YTV+G
Sbjct: 840  IGTGWSSYIPNYNPRDIIGNIRRLLNNEPMEPMEPWYKGFRGTIEKTATKEAGASYTVSG 899

Query: 2094 IIEEVSDTTLRVTELPVRKWTQDYKDFLESLY--------PFIEDVREYHTTDSVNFEID 1939
            I+EEV +TT+RVTELPVRKWTQDYK+FLES+         PFI++ R++    +V  +I 
Sbjct: 900  IVEEVDETTIRVTELPVRKWTQDYKEFLESIMMGNEKVKDPFIKEFRDHTDDTTVYLDII 959

Query: 1938 LSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSIRFEFYE 1759
            +SEEN+ +AKQEGLLKKFKLTTTISTSNMHLFDS+G+IKK+D PE+ILE+FF +R EFYE
Sbjct: 960  MSEENLLMAKQEGLLKKFKLTTTISTSNMHLFDSQGIIKKFDNPEQILEEFFHLRLEFYE 1019

Query: 1758 KRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPFPKKAKT 1579
            KRKK L+DNL+ ELL L+NKVRFI+ VVEG I+VSNR+RADL LELKEKGFTPFPKK K+
Sbjct: 1020 KRKKVLLDNLQLELLKLDNKVRFILAVVEGSIIVSNRKRADLFLELKEKGFTPFPKK-KS 1078

Query: 1578 TEISVAGSTDVPEETEENSDMA-SQGVRASDYDYLLSMSIGSLTIEKVQELCNNRDKLIQ 1402
             E +VAGS +  EETEE+S++A S+GVRASDY+YL+SM+IGSLT+EKVQELC +RDKL  
Sbjct: 1079 VEAAVAGSIEDAEETEESSEVATSKGVRASDYEYLISMAIGSLTLEKVQELCADRDKLKG 1138

Query: 1401 EVEEMRKATINSLWTKDLDALERELDEQDRRDALTEEEAMEIKAKTRRASKP-----ATK 1237
            EV+++ KAT  SLWTKDLDALE +LDEQD  DA  E    E+++K  +   P     A K
Sbjct: 1139 EVDDLIKATPKSLWTKDLDALESQLDEQDISDAQAEAARKEMRSKAMKDDGPKPTRQAPK 1198

Query: 1236 NPRKNNKKISKTESAAEPMEISTNSEIETVSANIGPFPPSDNARVAVQKKAP-RKGKSVA 1060
            NPRK NKK S TE   EPMEIS++S +ET +      P       A  KKAP RKGK+ +
Sbjct: 1199 NPRKYNKKASNTEPTTEPMEISSSSALETNNVVEVAKPKGK----AGPKKAPARKGKTFS 1254

Query: 1059 ALKDE--EDDDEILALNERIAAYNL-DSSPDHAEAPEAEVSEVQIKNKGPTRKAAATKKP 889
             L+DE  EDDDE+LAL +R+AAYNL  SSPD +E  E E+       K    K A TKKP
Sbjct: 1255 VLRDEDDEDDDEVLALKDRLAAYNLGSSSPDQSETMETEIP------KREPSKRATTKKP 1308

Query: 888  LSTVT-----XXXXXXXXXXXXXXEVIPAEEKKKAGRKPATAKTTKPPVGAKKRGPAAKQ 724
            L +VT                     + A  K+K  +K A +K  KP    KKRG A K 
Sbjct: 1309 LVSVTEISDDDDDQIEISDDEDFELEVEAAPKEKGRKKTANSKAAKPTAAPKKRGQANKT 1368

Query: 723  SQILGQKLITEVLQGA---ADSPDKKVRKMRISPFNKKSGSVLGR-----------XXXX 586
            SQ++GQKLITEVL+ A     SP+KKVR+MR SPFNKKSGSVL R               
Sbjct: 1369 SQLVGQKLITEVLKPADVSKISPEKKVRRMRPSPFNKKSGSVLERLSQQETDKISPESEE 1428

Query: 585  XXXXXXXXXXXXXXESNQVVVPRARPQRANSR-KATYVLSDDDSED 451
                          ES QVVVPRARP+R  +R KA YV+SD +++D
Sbjct: 1429 QEESPASNASGSTEESAQVVVPRARPRRGGNRGKAKYVMSDSENDD 1474


>ref|XP_011087914.1| PREDICTED: DNA topoisomerase 2 isoform X1 [Sesamum indicum]
          Length = 1484

 Score = 2034 bits (5269), Expect = 0.0
 Identities = 1047/1475 (70%), Positives = 1194/1475 (80%), Gaps = 35/1475 (2%)
 Frame = -1

Query: 4770 KKAPLTSSNNANIPP-EXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHNQT 4594
            KKAPLT+SNNANIPP E          KTIEQTYQKKTQLEHILLRPDTYIGSIEKH QT
Sbjct: 5    KKAPLTTSNNANIPPPETTIAGGGAGKKTIEQTYQKKTQLEHILLRPDTYIGSIEKHTQT 64

Query: 4593 LWVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVYNN 4414
            LWVYE++QMVQK ITYVPGLYKIFDEILVNAADNKQRDPKM+S+KVTID E+N ISVYNN
Sbjct: 65   LWVYEDEQMVQKSITYVPGLYKIFDEILVNAADNKQRDPKMDSVKVTIDVESNSISVYNN 124

Query: 4413 GDGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVIET 4234
            GDGVPVEIHQEEGVYVPELIFGHLLTSSNYDD+EKKTTGGRNGYGAKLTNIFSTEFVIET
Sbjct: 125  GDGVPVEIHQEEGVYVPELIFGHLLTSSNYDDNEKKTTGGRNGYGAKLTNIFSTEFVIET 184

Query: 4233 ADGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVALMK 4054
            ADG+RQRKYKQVF+ NMG KS+P+ISKCK  ENWTK+TFKPDL+KF+M++LE+DVVALMK
Sbjct: 185  ADGKRQRKYKQVFSNNMGTKSEPIISKCKAGENWTKITFKPDLAKFSMSYLEEDVVALMK 244

Query: 4053 KRVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAF--------RIEEKV-DRWEV 3901
            KRVID+AGCLGK VKVELNG     +SF +YC+LYLK A         R EE+V DRW++
Sbjct: 245  KRVIDVAGCLGKTVKVELNGRLFHFKSFSNYCDLYLKPASASSSDPLPRFEEEVHDRWQI 304

Query: 3900 CVSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYV---NKKRKNANLKPHSVR 3730
            C+S S+GQFQQVSFVN I+T+KGGTHVDYVTN+I +HL   +   NKK K  +LKPH+V+
Sbjct: 305  CISRSEGQFQQVSFVNGIATVKGGTHVDYVTNKITSHLVTVIKNKNKKNKKFDLKPHAVK 364

Query: 3729 NHLWVFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVANSEIVNNILEWAEF 3550
            NHLWVFVN LIDNPAFDSQTKETLTLR  SFGS    S KFL KVA S+I+ NI EWAEF
Sbjct: 365  NHLWVFVNALIDNPAFDSQTKETLTLRAASFGSSWDFSSKFLDKVAKSDIMKNIEEWAEF 424

Query: 3549 KEKKDLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGR 3370
            K+KKDLKKTDG+K +RI GLTKLADAN AGG+NSEKCTLILTEGDSA  LAIAGLSVVGR
Sbjct: 425  KQKKDLKKTDGSKDRRIYGLTKLADANEAGGKNSEKCTLILTEGDSAKALAIAGLSVVGR 484

Query: 3369 DHYGVFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTD 3190
            DHYGVFPLRGKLLNVR+AS  Q+  N EIQ+IK+ILGLQHGKQYDS+KSLRYGHLMIMTD
Sbjct: 485  DHYGVFPLRGKLLNVREASHNQLMQNVEIQHIKQILGLQHGKQYDSVKSLRYGHLMIMTD 544

Query: 3189 QDHDGSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKR-SFYTMPEYESW 3013
            QDHDGSHIKGLLINFIHSFWPSLL++P+FL+EFITPIVKA+ K+G+K+ SFYTMP+YE+W
Sbjct: 545  QDHDGSHIKGLLINFIHSFWPSLLKVPTFLLEFITPIVKASRKDGKKKESFYTMPQYEAW 604

Query: 3012 KESLGDKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKKK 2833
            KE LG  A++WSIKYYKGLGTSTD+EGKEYF+DL KHKKDFVW D+ DGEAIELAFSKKK
Sbjct: 605  KEKLGADAKNWSIKYYKGLGTSTDQEGKEYFEDLGKHKKDFVWVDEQDGEAIELAFSKKK 664

Query: 2832 IEARKNWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRKI 2653
            IEARKNW+RQFEPGTYL ++DK IKYRDFV+KELILFSIADLQRSIPSMVDGLKPGQRKI
Sbjct: 665  IEARKNWIRQFEPGTYLSEQDKHIKYRDFVHKELILFSIADLQRSIPSMVDGLKPGQRKI 724

Query: 2652 LFCAFKRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNGQ 2473
            LFC+FKRNF+ EAKV QF+GYVSEHSAYHHGEQSLASTIIGMAQ YVGSNNIN+L PNGQ
Sbjct: 725  LFCSFKRNFIKEAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQDYVGSNNINLLLPNGQ 784

Query: 2472 FGTRNQGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVVL 2293
            FGTR QGGKDHASARYIFTQLS ITR+LFPK DDILL+Y NEDGQ+IEP+WYVPIIP+VL
Sbjct: 785  FGTRGQGGKDHASARYIFTQLSPITRYLFPKADDILLNYLNEDGQSIEPSWYVPIIPMVL 844

Query: 2292 VNGSEGIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAGA 2113
            VNGSEGIGTGWSSF+PNYNP DIIAN+RH+L DEPM PM PWYKGFRG+IEKTATKEAG 
Sbjct: 845  VNGSEGIGTGWSSFIPNYNPLDIIANLRHLLNDEPMVPMHPWYKGFRGSIEKTATKEAGN 904

Query: 2112 TYTVTGIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY--------PFIEDVREYHTTDS 1957
            +YTV+GIIEE+ + TL +TELPVRKWTQDYK+FLES+         PFIE  R+    + 
Sbjct: 905  SYTVSGIIEELDERTLSITELPVRKWTQDYKEFLESISAENEKSKDPFIEGCRDNSGGEI 964

Query: 1956 VNFEIDLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSI 1777
            VNF + LS EN+ IAKQEGLLKKFKLTT+ISTSNMHLFD+KGVIKKYDTPE+ILE+FF I
Sbjct: 965  VNFLVYLSAENLLIAKQEGLLKKFKLTTSISTSNMHLFDAKGVIKKYDTPEQILEEFFHI 1024

Query: 1776 RFEFYEKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPF 1597
            R EFYEKRK+ L+ NLE ++L  ENK RFI  VVE  I+VSNRRRADL LELKEKGFTPF
Sbjct: 1025 RLEFYEKRKRVLLANLENDMLKCENKCRFIQCVVESSIIVSNRRRADLFLELKEKGFTPF 1084

Query: 1596 PKKAKTTEISVAGSTDVPEETEENSDMASQGVRASDYDYLLSMSIGSLTIEKVQELCNNR 1417
            PKK    E+++AGS D  EETEEN+        ASDYDYLLS++IG+LT EK+QEL   R
Sbjct: 1085 PKKKTAAEVAIAGSLDEAEETEENTS-------ASDYDYLLSLAIGTLTAEKIQELRAER 1137

Query: 1416 DKLIQEVEEMRKATINSLWTKDLDALERE-LDEQDRRDALTEEEAMEIKAKTRRASKPAT 1240
            DKL+QEVE +++AT+ SLW  DLDALE + ++EQ++ +   E+E  +I   T   S+P  
Sbjct: 1138 DKLMQEVENLKRATVKSLWMNDLDALESKFIEEQNKSEKKWEKEREKING-TVNISRPVQ 1196

Query: 1239 KNPRKNNKKISKTESAAEPMEISTNSEIETVSANIGPFPPSDNARVAVQKKAPRKGKSVA 1060
            KNPRKNNKK +  ES    ME+S ++  E  + N G        R A +KKAP + K V 
Sbjct: 1197 KNPRKNNKKATNKES---QMEVSGDTVPE--AGNAGDI-KKPKGRTAAKKKAPAE-KQVT 1249

Query: 1059 ALKDEEDDDEILALNERIAAYNLDSSPDHAEAPEA-EVSEVQIKNKGPTRKAAATKKPLS 883
            ++ DE DD+EI  L  R+AAYN DSSPD  +  E  EVS++Q K K P+RKAAA KKPL 
Sbjct: 1250 SVADENDDEEISDLRHRLAAYNFDSSPDRPQEMETEEVSQLQTKKKEPSRKAAAQKKPLP 1309

Query: 882  TVT-XXXXXXXXXXXXXXEVIPAEEKKKAGRKPATAKTTKPPVGAKKRGPAA-KQSQILG 709
            TV+               + +P E+KKK GRKP  AK  KPP   KKRGPAA KQSQ LG
Sbjct: 1310 TVSESHDDDDIQIIDDDDDFVPDEKKKKGGRKPGNAKAAKPP-STKKRGPAASKQSQTLG 1368

Query: 708  QKLITEVLQGAADSPDKKVRKMRISPFNKKSGSVLGRXXXXXXXXXXXXXXXXXXESN-- 535
            QKLITEVL+ A +SP+KKVRK+R SPFNKKSGS+LGR                   ++  
Sbjct: 1369 QKLITEVLKPAENSPEKKVRKVRASPFNKKSGSILGRTINVEEEEEGSTSAEQADSTSTL 1428

Query: 534  -------QVVVPRARPQRANSRKATYVLSDDDSED 451
                   Q V P+ARPQRAN  KATYV+SDD   D
Sbjct: 1429 GSVTDVGQAVAPKARPQRANRGKATYVISDDSESD 1463


>ref|XP_011087923.1| PREDICTED: DNA topoisomerase 2 isoform X2 [Sesamum indicum]
          Length = 1483

 Score = 2032 bits (5264), Expect = 0.0
 Identities = 1046/1475 (70%), Positives = 1193/1475 (80%), Gaps = 35/1475 (2%)
 Frame = -1

Query: 4770 KKAPLTSSNNANIPP-EXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHNQT 4594
            KKAPLT+SNNANIPP E          KTIEQTYQKKTQLEHILLRPDTYIGSIEKH QT
Sbjct: 5    KKAPLTTSNNANIPPPETTIAGGGAGKKTIEQTYQKKTQLEHILLRPDTYIGSIEKHTQT 64

Query: 4593 LWVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVYNN 4414
            LWVYE++QMVQK ITYVPGLYKIFDEILVNAADNKQRDPKM+S+KVTID E+N ISVYNN
Sbjct: 65   LWVYEDEQMVQKSITYVPGLYKIFDEILVNAADNKQRDPKMDSVKVTIDVESNSISVYNN 124

Query: 4413 GDGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVIET 4234
            GDGVPVEIHQEEGVYVPELIFGHLLTSSNYDD+EKKTTGGRNGYGAKLTNIFSTEFVIET
Sbjct: 125  GDGVPVEIHQEEGVYVPELIFGHLLTSSNYDDNEKKTTGGRNGYGAKLTNIFSTEFVIET 184

Query: 4233 ADGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVALMK 4054
            ADG+RQRKYKQVF+ NMG KS+P+ISKCK  ENWTK+TFKPDL+KF+M++LE+DVVALMK
Sbjct: 185  ADGKRQRKYKQVFSNNMGTKSEPIISKCKAGENWTKITFKPDLAKFSMSYLEEDVVALMK 244

Query: 4053 KRVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAF--------RIEEKV-DRWEV 3901
            KRVID+AGCLGK VKVELNG     +SF +YC+LYLK A         R EE+V DRW++
Sbjct: 245  KRVIDVAGCLGKTVKVELNGRLFHFKSFSNYCDLYLKPASASSSDPLPRFEEEVHDRWQI 304

Query: 3900 CVSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYV---NKKRKNANLKPHSVR 3730
            C+S S+GQFQQVSFVN I+T+KGGTHVDYVTN+I +HL   +   NKK K  +LKPH+V+
Sbjct: 305  CISRSEGQFQQVSFVNGIATVKGGTHVDYVTNKITSHLVTVIKNKNKKNKKFDLKPHAVK 364

Query: 3729 NHLWVFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVANSEIVNNILEWAEF 3550
            NHLWVFVN LIDNPAFDSQTKETLTLR  SFGS    S KFL KVA S+I+ NI EWAEF
Sbjct: 365  NHLWVFVNALIDNPAFDSQTKETLTLRAASFGSSWDFSSKFLDKVAKSDIMKNIEEWAEF 424

Query: 3549 KEKKDLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGR 3370
            K+KKDLKKTDG+K +RI GLTKLADAN AGG+NSEKCTLILTEGDSA  LAIAGLSVVGR
Sbjct: 425  KQKKDLKKTDGSKDRRIYGLTKLADANEAGGKNSEKCTLILTEGDSAKALAIAGLSVVGR 484

Query: 3369 DHYGVFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTD 3190
            DHYGVFPLRGKLLNVR+AS  Q+  N EIQ+IK+ILGLQHGKQYDS+KSLRYGHLMIMTD
Sbjct: 485  DHYGVFPLRGKLLNVREASHNQLMQNVEIQHIKQILGLQHGKQYDSVKSLRYGHLMIMTD 544

Query: 3189 QDHDGSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKR-SFYTMPEYESW 3013
            QDHDGSHIKGLLINFIHSFWPSLL++P+FL+EFITPIVKA+ K+G+K+ SFYTMP+YE+W
Sbjct: 545  QDHDGSHIKGLLINFIHSFWPSLLKVPTFLLEFITPIVKASRKDGKKKESFYTMPQYEAW 604

Query: 3012 KESLGDKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKKK 2833
            KE LG  A++WSIKYYKGLGTSTD+EGKEYF+DL KHKKDFVW D+ DGEAIELAFSKKK
Sbjct: 605  KEKLGADAKNWSIKYYKGLGTSTDQEGKEYFEDLGKHKKDFVWVDEQDGEAIELAFSKKK 664

Query: 2832 IEARKNWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRKI 2653
            IEARKNW+RQFEPGTYL ++DK IKYRDFV+KELILFSIADLQRSIPSMVDGLKPGQRKI
Sbjct: 665  IEARKNWIRQFEPGTYLSEQDKHIKYRDFVHKELILFSIADLQRSIPSMVDGLKPGQRKI 724

Query: 2652 LFCAFKRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNGQ 2473
            LFC+FKRNF+ EAKV QF+GYVSEHSAYHHGEQSLASTIIGMAQ YVGSNNIN+L PNGQ
Sbjct: 725  LFCSFKRNFIKEAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQDYVGSNNINLLLPNGQ 784

Query: 2472 FGTRNQGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVVL 2293
            FGTR QGGKDHASARYIFTQLS ITR+LFPK DDILL+Y NEDGQ+IEP+WYVPIIP+VL
Sbjct: 785  FGTRGQGGKDHASARYIFTQLSPITRYLFPKADDILLNYLNEDGQSIEPSWYVPIIPMVL 844

Query: 2292 VNGSEGIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAGA 2113
            VNGSEGIGTGWSSF+PNYNP DIIAN+RH+L DEPM PM PWYKGFRG+IEKTATKEAG 
Sbjct: 845  VNGSEGIGTGWSSFIPNYNPLDIIANLRHLLNDEPMVPMHPWYKGFRGSIEKTATKEAGN 904

Query: 2112 TYTVTGIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY--------PFIEDVREYHTTDS 1957
            +YTV+GIIEE+ + TL +TELPVRKWTQDYK+FLES+         PFIE  R+    + 
Sbjct: 905  SYTVSGIIEELDERTLSITELPVRKWTQDYKEFLESISAENEKSKDPFIEGCRDNSGGEI 964

Query: 1956 VNFEIDLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSI 1777
            VNF + LS EN+ IAKQEGLLKKFKLTT+ISTSNMHLFD+KGVIKKYDTPE+ILE+FF I
Sbjct: 965  VNFLVYLSAENLLIAKQEGLLKKFKLTTSISTSNMHLFDAKGVIKKYDTPEQILEEFFHI 1024

Query: 1776 RFEFYEKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPF 1597
            R EFYEKRK+ L+ NLE ++L  ENK RFI  VVE  I+VSNRRRADL LELKEKGFTPF
Sbjct: 1025 RLEFYEKRKRVLLANLENDMLKCENKCRFIQCVVESSIIVSNRRRADLFLELKEKGFTPF 1084

Query: 1596 PKKAKTTEISVAGSTDVPEETEENSDMASQGVRASDYDYLLSMSIGSLTIEKVQELCNNR 1417
            PKK    E+++AGS D  EETEEN+        ASDYDYLLS++IG+LT EK+QEL   R
Sbjct: 1085 PKKKTAAEVAIAGSLDEAEETEENTS-------ASDYDYLLSLAIGTLTAEKIQELRAER 1137

Query: 1416 DKLIQEVEEMRKATINSLWTKDLDALERE-LDEQDRRDALTEEEAMEIKAKTRRASKPAT 1240
            DKL+QEVE +++AT+ SLW  DLDALE + ++EQ++ +   E+E  +I   T   S+P  
Sbjct: 1138 DKLMQEVENLKRATVKSLWMNDLDALESKFIEEQNKSEKKWEKEREKING-TVNISRPVQ 1196

Query: 1239 KNPRKNNKKISKTESAAEPMEISTNSEIETVSANIGPFPPSDNARVAVQKKAPRKGKSVA 1060
            KNPRKNNKK +  ES    ME+S ++  E  + N G        R A +KKAP   + V 
Sbjct: 1197 KNPRKNNKKATNKES---QMEVSGDTVPE--AGNAGDI-KKPKGRTAAKKKAP--AEKVT 1248

Query: 1059 ALKDEEDDDEILALNERIAAYNLDSSPDHAEAPEA-EVSEVQIKNKGPTRKAAATKKPLS 883
            ++ DE DD+EI  L  R+AAYN DSSPD  +  E  EVS++Q K K P+RKAAA KKPL 
Sbjct: 1249 SVADENDDEEISDLRHRLAAYNFDSSPDRPQEMETEEVSQLQTKKKEPSRKAAAQKKPLP 1308

Query: 882  TVT-XXXXXXXXXXXXXXEVIPAEEKKKAGRKPATAKTTKPPVGAKKRGPAA-KQSQILG 709
            TV+               + +P E+KKK GRKP  AK  KPP   KKRGPAA KQSQ LG
Sbjct: 1309 TVSESHDDDDIQIIDDDDDFVPDEKKKKGGRKPGNAKAAKPP-STKKRGPAASKQSQTLG 1367

Query: 708  QKLITEVLQGAADSPDKKVRKMRISPFNKKSGSVLGRXXXXXXXXXXXXXXXXXXESN-- 535
            QKLITEVL+ A +SP+KKVRK+R SPFNKKSGS+LGR                   ++  
Sbjct: 1368 QKLITEVLKPAENSPEKKVRKVRASPFNKKSGSILGRTINVEEEEEGSTSAEQADSTSTL 1427

Query: 534  -------QVVVPRARPQRANSRKATYVLSDDDSED 451
                   Q V P+ARPQRAN  KATYV+SDD   D
Sbjct: 1428 GSVTDVGQAVAPKARPQRANRGKATYVISDDSESD 1462


>ref|XP_002274267.1| PREDICTED: DNA topoisomerase 2 [Vitis vinifera]
          Length = 1489

 Score = 2020 bits (5233), Expect = 0.0
 Identities = 1035/1481 (69%), Positives = 1199/1481 (80%), Gaps = 43/1481 (2%)
 Frame = -1

Query: 4767 KAPLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHNQTLW 4588
            K PL SSNNAN+P +          KTIE+TYQKK+QLEHILLRPDTYIGSIEKH Q LW
Sbjct: 6    KLPLQSSNNANMPAKPAG-------KTIEETYQKKSQLEHILLRPDTYIGSIEKHTQALW 58

Query: 4587 VYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVYNNGD 4408
            V+E  +MV + ++YVPGLYKIFDEILVNAADNKQRDP M+S+KV ID E NCISVYNNGD
Sbjct: 59   VFENNEMVHRSVSYVPGLYKIFDEILVNAADNKQRDPSMDSVKVVIDVEKNCISVYNNGD 118

Query: 4407 GVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVIETAD 4228
            GVPVEIHQEEGVYVPE+IFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEFVIETAD
Sbjct: 119  GVPVEIHQEEGVYVPEMIFGHLLTSSNYDDDVKKTTGGRNGYGAKLTNIFSTEFVIETAD 178

Query: 4227 GRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVALMKKR 4048
            GRRQ+KYKQVF+ NMG KS+PVI+KCKE ENWTKV+FKPDL+KFNMTHLEDDVVALMKKR
Sbjct: 179  GRRQKKYKQVFSNNMGKKSEPVITKCKERENWTKVSFKPDLAKFNMTHLEDDVVALMKKR 238

Query: 4047 VIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAF--------RIEEKV-DRWEVCV 3895
            V+D+AGCLGK VKVELNG+ I V+SF DY NLYL+SA         RI EKV +RWE+CV
Sbjct: 239  VVDIAGCLGKTVKVELNGQRIPVKSFNDYVNLYLQSAAKSRPESLPRIAEKVNERWEICV 298

Query: 3894 SLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYVNKKRKNANLKPHSVRNHLWV 3715
            SLS+GQFQQVSFVNSI+TIKGGTHVDYVTNQIA  +   VNKK KNAN+K H+V+NHLWV
Sbjct: 299  SLSEGQFQQVSFVNSIATIKGGTHVDYVTNQIANFVMSIVNKKNKNANIKAHTVKNHLWV 358

Query: 3714 FVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVANSEIVNNILEWAEFKEKKD 3535
            FVN LIDNPAFDSQTKETLT+RQ SFGS+C+LS +FL KV+ S +V ++L WA++K+ KD
Sbjct: 359  FVNALIDNPAFDSQTKETLTIRQSSFGSKCELSQEFLKKVSKSGVVESLLSWADYKQNKD 418

Query: 3534 LKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGRDHYGV 3355
            LKKTDGTK +R+TG+TKL DAN+AGGRNSEKCTLILTEGDSA  LA+AG+SVVGR+HYGV
Sbjct: 419  LKKTDGTKRQRLTGITKLEDANDAGGRNSEKCTLILTEGDSAKALAMAGISVVGRNHYGV 478

Query: 3354 FPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTDQDHDG 3175
            FPLRGKLLNVRDA  KQI +NAEIQNIK+ILGLQ GK+YDSIKSLRYGHLMIMTDQDHDG
Sbjct: 479  FPLRGKLLNVRDAQKKQILENAEIQNIKQILGLQQGKEYDSIKSLRYGHLMIMTDQDHDG 538

Query: 3174 SHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKRSFYTMPEYESWKESLGD 2995
            SHIKGLLINFIHSFWPSLL+IPSFLVEFITPIVKATH+NG   SFY+MPEYESWKESLG 
Sbjct: 539  SHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHRNGRVLSFYSMPEYESWKESLGG 598

Query: 2994 KARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKKKIEARKN 2815
             A  WSIKYYKGLGTST KEGKEYFKDL KHKKDF+W D+ DG+AIELAFSKKKIE RKN
Sbjct: 599  NASGWSIKYYKGLGTSTSKEGKEYFKDLGKHKKDFMWVDEKDGDAIELAFSKKKIEERKN 658

Query: 2814 WLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRKILFCAFK 2635
            WLRQF+PGTYLDQ++KLIKY DFVNKELILFS+ADLQRSIPSMVDGLKPGQRKILFC+FK
Sbjct: 659  WLRQFQPGTYLDQKEKLIKYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFCSFK 718

Query: 2634 RNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNGQFGTRNQ 2455
            RNF+ EAK+ QF+GYVSEHSAYHHGEQSLASTIIGMAQ +VGSNNIN+L PNGQFGTR+Q
Sbjct: 719  RNFIKEAKIAQFSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRHQ 778

Query: 2454 GGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVVLVNGSEG 2275
            GGKDHASARYI+T+LS ITRFLFPKDDDILLDY NEDGQ+IEPTWYVP IP+VLVNGSEG
Sbjct: 779  GGKDHASARYIYTRLSPITRFLFPKDDDILLDYLNEDGQSIEPTWYVPTIPMVLVNGSEG 838

Query: 2274 IGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKT-ATKEAGATYTVT 2098
            IGTGWSS +PNYNPRDIIANVR +L  E MEPMDPWY+GFRGTIEKT  TK+    YTV 
Sbjct: 839  IGTGWSSSIPNYNPRDIIANVRRLLNGEMMEPMDPWYRGFRGTIEKTDPTKQESVGYTVK 898

Query: 2097 GIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY--------PFIEDVREYHTTDSVNFEI 1942
            GIIEEV++TTLR++ELPVRKWTQDYK+FLES+         PFI+D +E++   +V+FE+
Sbjct: 899  GIIEEVNETTLRISELPVRKWTQDYKEFLESIMTGNDKIKDPFIKDYKEHNDDTTVHFEV 958

Query: 1941 DLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSIRFEFY 1762
             +SEEN+ +AKQEGLL+KFKLTT ISTSNMHLFDS G IKKY+TPE+ILE+FF +R EFY
Sbjct: 959  IMSEENLLMAKQEGLLQKFKLTTKISTSNMHLFDSNGTIKKYETPEQILEEFFHLRLEFY 1018

Query: 1761 EKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPFPKKAK 1582
            EKRK+ L+DNLE ELL LENKVRFI+ VV G+I+VSNR+RADL  EL +KGFTPFPKK+K
Sbjct: 1019 EKRKRVLLDNLELELLKLENKVRFILGVVRGEIIVSNRKRADLFHELHQKGFTPFPKKSK 1078

Query: 1581 TTEISVAGSTDVPEETEENSDMASQ-GVRASDYDYLLSMSIGSLTIEKVQELCNNRDKLI 1405
            + EI+VAG+TD  EE EEN+D  S+ GVRA+DY+YLLSM+IG+LT+EKVQELC +RDKL 
Sbjct: 1079 SVEIAVAGATDDTEEAEENTDAVSKGGVRATDYEYLLSMAIGTLTLEKVQELCADRDKLN 1138

Query: 1404 QEVEEMRKATINSLWTKDLDALERELDEQDRRDALTEEEAMEIKAKT-----RRASKPAT 1240
            + V++++KAT  +LW  DLDALERELDEQD+ DA  EE   ++K++       + S+ A 
Sbjct: 1139 KGVDDLKKATPKALWITDLDALERELDEQDKNDARAEETRKQLKSRVMSEAGMKVSRQAP 1198

Query: 1239 KNPRKNNKKISKTESAAEPMEISTNSEIETVSANIGPFPPSDNARVAVQKKAPRKGKSVA 1060
            KNPRKNNKK +  E AAE M++S +S +E  S    P       R A +K   +K +   
Sbjct: 1199 KNPRKNNKKANNAEPAAETMDVSASSAMEMESV---PEVVKPKGRAAPRKAPAKKKEMPT 1255

Query: 1059 ALKDEEDDDEILALNERIAAYNLDSSPDHAEAPEAEVSEV-QIKNKGPTRKAAATKKPLS 883
            ++  +EDDDE+  L ER+AAYNL+SSPD + A EAEV +V   + K P+R+AAA KKPL+
Sbjct: 1256 SVLKDEDDDEVHELKERLAAYNLESSPDGSAAMEAEVPQVPAARKKEPSRRAAAQKKPLA 1315

Query: 882  TVTXXXXXXXXXXXXXXEVIPAEE-KKKAGRKPAT---AKTTKPPVGA--KKRGPAAKQS 721
            + T              E + A + KKK GRKPA    A   KP   A   KRG A KQ 
Sbjct: 1316 SFTEISDDDEDDEDFEVEEVSASDVKKKGGRKPAANAKAAAAKPAAAAAKNKRGAANKQQ 1375

Query: 720  -QILGQKLITEVLQGAAD---SPDKKVRKMRISPFNKKSGSVLG-------RXXXXXXXX 574
             Q+LGQ L+TE+ + A     SP+KKVRKMR SPFNKKSGSVLG                
Sbjct: 1376 PQLLGQTLLTEIFKPAETLGISPEKKVRKMRASPFNKKSGSVLGSTGEEDETAETEENSG 1435

Query: 573  XXXXXXXXXXESNQVVVP-RARPQRANSRKATYVLSDDDSE 454
                      ESN+VV+P R RPQR N  +  YV+SD +S+
Sbjct: 1436 SASTSNSSGGESNEVVMPARTRPQRENRVQTRYVVSDSESD 1476


>ref|XP_012849677.1| PREDICTED: DNA topoisomerase 2 [Erythranthe guttatus]
            gi|604314150|gb|EYU27037.1| hypothetical protein
            MIMGU_mgv1a000169mg [Erythranthe guttata]
          Length = 1503

 Score = 2016 bits (5223), Expect = 0.0
 Identities = 1030/1484 (69%), Positives = 1189/1484 (80%), Gaps = 42/1484 (2%)
 Frame = -1

Query: 4770 KKAPLTSSNNANIPPEXXXXXXXXXA---KTIEQTYQKKTQLEHILLRPDTYIGSIEKHN 4600
            KK PLT+SNNANIPP              KTIEQTYQKKTQLEHILLRPDTYIGSIEKH 
Sbjct: 5    KKPPLTTSNNANIPPSETTAAAAAAGGGKKTIEQTYQKKTQLEHILLRPDTYIGSIEKHT 64

Query: 4599 QTLWVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVY 4420
            QTLW+YE + MVQK ITYVPGLYKIFDEILVNAADNKQRDP+M+S+KVTID E+N ISVY
Sbjct: 65   QTLWIYENENMVQKSITYVPGLYKIFDEILVNAADNKQRDPRMDSVKVTIDVESNYISVY 124

Query: 4419 NNGDGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVI 4240
            NNGDGVPVEIHQEEGVYVPELIFGHLLTSSNYDD+EKKTTGGRNGYGAKLTNIFSTEFVI
Sbjct: 125  NNGDGVPVEIHQEEGVYVPELIFGHLLTSSNYDDNEKKTTGGRNGYGAKLTNIFSTEFVI 184

Query: 4239 ETADGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVAL 4060
            ETADG+R +KYKQVF+ NMG KS+PVISKCK  ENWTK+TFKPDL+KF+M+ LE+DVVAL
Sbjct: 185  ETADGKRLKKYKQVFSNNMGTKSEPVISKCKSGENWTKITFKPDLTKFSMSCLEEDVVAL 244

Query: 4059 MKKRVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAF--------RIEEKV-DRW 3907
            MKKRVID+AGCLGK VKVELNG+    +SF +YC+LYLKSA         R EE+V DRW
Sbjct: 245  MKKRVIDIAGCLGKTVKVELNGQQFHFKSFSNYCDLYLKSASLASSEPLPRFEEEVHDRW 304

Query: 3906 EVCVSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYV---NKKRKNANLKPHS 3736
            +VCVS S+GQFQQVSFVN I+TIKGGTHVDYVTN+I +HL   +   NKK K  +LKPH+
Sbjct: 305  QVCVSRSEGQFQQVSFVNGIATIKGGTHVDYVTNKITSHLVAVIKNKNKKNKKFDLKPHT 364

Query: 3735 VRNHLWVFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVANSEIVNNILEWA 3556
            V+NHLWVFVN LIDNPAFDSQTKETLTLR  SFGS    S KFL KV+ S+I+ NI EWA
Sbjct: 365  VKNHLWVFVNALIDNPAFDSQTKETLTLRAGSFGSSWDFSSKFLDKVSKSDIMKNIEEWA 424

Query: 3555 EFKEKKDLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVV 3376
            EFK+KKDLKKTDG K +RI GLTKLADAN AGG+NSEKCTLILTEGDSA  LAIAG+SVV
Sbjct: 425  EFKQKKDLKKTDGAKDRRIYGLTKLADANEAGGKNSEKCTLILTEGDSAKALAIAGISVV 484

Query: 3375 GRDHYGVFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIM 3196
            GRDHYGVFPLRGKLLNVR+AS  Q+  N EIQ+IK+ILGLQHGKQYDS+KSLRYGHLMIM
Sbjct: 485  GRDHYGVFPLRGKLLNVREASHTQLMQNVEIQHIKQILGLQHGKQYDSVKSLRYGHLMIM 544

Query: 3195 TDQDHDGSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGE-KRSFYTMPEYE 3019
            TDQDHDGSHIKGLLINFIHSFWPSLL++PSF++EFITPIVKAT+K G+ K+SFYTMP+YE
Sbjct: 545  TDQDHDGSHIKGLLINFIHSFWPSLLKVPSFMLEFITPIVKATNKYGKNKKSFYTMPQYE 604

Query: 3018 SWKESLGDKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSK 2839
            +WKES+G  A++W+IKYYKGLGTSTDKEGKEYF+DL KHKKDFVW D+ DG+AIELAFSK
Sbjct: 605  AWKESIGSDAKNWTIKYYKGLGTSTDKEGKEYFEDLGKHKKDFVWVDEQDGDAIELAFSK 664

Query: 2838 KKIEARKNWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQR 2659
            KKIEARK+WLRQFEPGTYLD  D  IKYRDFV+KELILFSIADLQRSIPSMVDGLKPGQR
Sbjct: 665  KKIEARKSWLRQFEPGTYLDDRDSHIKYRDFVHKELILFSIADLQRSIPSMVDGLKPGQR 724

Query: 2658 KILFCAFKRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPN 2479
            KIL+C+FKRNFV EAKV QF+GYVSEHSAYHHGEQSLASTIIGMAQ YVGSNNIN+L PN
Sbjct: 725  KILYCSFKRNFVKEAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQDYVGSNNINLLLPN 784

Query: 2478 GQFGTRNQGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPV 2299
            GQFGTR QGGKDHASARY++TQLS +TRFLFPK DDILLDY NEDGQ IEPTWYVPIIP 
Sbjct: 785  GQFGTRGQGGKDHASARYVYTQLSPVTRFLFPKADDILLDYLNEDGQMIEPTWYVPIIPT 844

Query: 2298 VLVNGSEGIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEA 2119
            VLVNGSEGIGTGWSSFVPNYNP DIIANVRH+L  EPME M PWYKGF+GTIEKTATKEA
Sbjct: 845  VLVNGSEGIGTGWSSFVPNYNPLDIIANVRHLLNGEPMEAMHPWYKGFKGTIEKTATKEA 904

Query: 2118 GATYTVTGIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY--------PFIEDVREYHTT 1963
            G +YTVTGIIEEV +TTL +TELP+R+WTQDYK+FLES+         PFIE  R+    
Sbjct: 905  GFSYTVTGIIEEVDETTLTITELPIRRWTQDYKEFLESISAENDKSKDPFIEGCRDNSGG 964

Query: 1962 DSVNFEIDLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFF 1783
            + ++F + LSE N+ +AKQEGLLKKFKLTTT+STSNMHLFDSKGVIKKYD+PE+ILE+FF
Sbjct: 965  EIIHFAVYLSETNLLVAKQEGLLKKFKLTTTMSTSNMHLFDSKGVIKKYDSPEQILEEFF 1024

Query: 1782 SIRFEFYEKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFT 1603
             IR EFYEKRKKAL+ NLE ++L  +NK RFI  VVEG IVVSNR++ADL LELK KGFT
Sbjct: 1025 YIRLEFYEKRKKALLANLELDMLKCDNKYRFIRGVVEGTIVVSNRKKADLFLELKAKGFT 1084

Query: 1602 PFPKKAKTTEISVAGSTDVPEETEENSDM-ASQGVRASDYDYLLSMSIGSLTIEKVQELC 1426
            PFPKK  T E++VAG+TD  EETE+N+++  ++GV ASDYDYLLS++IG+LT EK+QEL 
Sbjct: 1085 PFPKKKNTPEVAVAGATDDTEETEDNTEVEIAKGVSASDYDYLLSLAIGTLTAEKLQELR 1144

Query: 1425 NNRDKLIQEVEEMRKATINSLWTKDLDALERE-LDEQDRRDALTEEEAMEIKAKTRRASK 1249
            + R++L QEVE+++K+T+ SLWTKDLDALE + +++    +   EE+   I+    + ++
Sbjct: 1145 DERERLTQEVEDLKKSTVKSLWTKDLDALEAKIIEDLKNSEKKWEEDRQRIQGGETKIAR 1204

Query: 1248 PATKNPRKNNKK-ISKTESAAEPMEISTNSEIETVSANIGPFPPSDNARVAVQKKAPRKG 1072
            P  KNPRKN KK  +K ES AE M++S N+  ET    +           A +KKAP   
Sbjct: 1205 PLAKNPRKNTKKATTKKESTAEHMDVSDNTVTET--DKVAEIKKPRGKAAAAKKKAP--V 1260

Query: 1071 KSVAALKDEEDDDEILALNERIAAYNLDSSPDHAEAPEAEVSEVQIKNKGPTRKAAATKK 892
              V A  DE+DDD +  L +RIAAYN DSSPD AE  E E+ ++Q K K PT++AA  KK
Sbjct: 1261 AKVVAEADEDDDDGVAELRQRIAAYNFDSSPDRAEDMETELPQLQTKKKEPTKRAAPRKK 1320

Query: 891  PLSTVTXXXXXXXXXXXXXXEVIPAEEKKKAGRKPATAK--TTKPPVGAKKRGPAAKQSQ 718
             +S V+              +  P ++KKK GRKPA  K    KPP GAKKRGPA+KQSQ
Sbjct: 1321 QVSIVSDDEEDDDIEIIDDDDFEPEDKKKKGGRKPANPKAAAAKPPAGAKKRGPASKQSQ 1380

Query: 717  ILGQKLITEVLQ---GAADSPDKKVRKMRISPFNKKSGSVLGRXXXXXXXXXXXXXXXXX 547
            ++GQKLITEVL+    A DSP+KKVR+MR SPFNKKS S+LGR                 
Sbjct: 1381 LVGQKLITEVLKPTAAADDSPEKKVRRMRASPFNKKSSSILGRGAINVDDDEDKEIGETS 1440

Query: 546  XESNQVVVPR----------ARPQRANSRKATYVLSDDDSEDGA 445
             E  +  V            +RP+R N R+ +YV+SDD   + A
Sbjct: 1441 NEQERSSVSDDVSKGVGPAVSRPKRVNRRQTSYVISDDSESEAA 1484


>ref|XP_010241214.1| PREDICTED: DNA topoisomerase 2-like isoform X2 [Nelumbo nucifera]
          Length = 1503

 Score = 2014 bits (5217), Expect = 0.0
 Identities = 1033/1499 (68%), Positives = 1195/1499 (79%), Gaps = 57/1499 (3%)
 Frame = -1

Query: 4770 KKAPLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHNQTL 4591
            +K PL +SN AN+P            KTIE+TYQKK+QLEHILLRPDTY+GSIEKH QTL
Sbjct: 5    RKLPLQTSNIANVPSSRPLVGSG---KTIEETYQKKSQLEHILLRPDTYVGSIEKHTQTL 61

Query: 4590 WVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVYNNG 4411
            WVY+  +MV +P+TYVPGLYKIFDEILVNAADNKQRDP M+S+KV IDAE NCISVYNNG
Sbjct: 62   WVYDGGEMVHRPVTYVPGLYKIFDEILVNAADNKQRDPSMDSVKVVIDAEQNCISVYNNG 121

Query: 4410 DGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVIETA 4231
            DGVPVEIHQEEGVYVPELIFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEF+IETA
Sbjct: 122  DGVPVEIHQEEGVYVPELIFGHLLTSSNYDDTVKKTTGGRNGYGAKLTNIFSTEFIIETA 181

Query: 4230 DGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVALMKK 4051
            DG+RQ+KYKQVF+ NMG KS+P I+KCK SENWTKVTFKPDL+KFN+THLEDDVVALMKK
Sbjct: 182  DGKRQKKYKQVFSNNMGKKSEPAITKCKGSENWTKVTFKPDLAKFNLTHLEDDVVALMKK 241

Query: 4050 RVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAF--------RIEEKV-DRWEVC 3898
            RVID+AGCLGK VKVELNG+ + V+SF DY NLYL+SA         RI EKV +RWEVC
Sbjct: 242  RVIDLAGCLGKTVKVELNGQRVPVKSFLDYVNLYLQSASKSRPEPLPRITEKVSERWEVC 301

Query: 3897 VSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYVNKKRKNANLKPHSVRNHLW 3718
            VSLS+GQFQQVSFVN I+TIKGGTHVDYVTNQI  H+   VNKK KNANLK H+V+NHLW
Sbjct: 302  VSLSEGQFQQVSFVNGIATIKGGTHVDYVTNQITNHVMTIVNKKNKNANLKAHTVKNHLW 361

Query: 3717 VFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVANSEIVNNILEWAEFKEKK 3538
            VFVN LIDNPAFDSQTKETLT RQ SFGS+C+LS +FL KVA S +V N+L WA+FK+ K
Sbjct: 362  VFVNSLIDNPAFDSQTKETLTTRQSSFGSKCELSQEFLKKVAKSGVVENLLSWADFKQSK 421

Query: 3537 DLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGRDHYG 3358
            DLKKTDG K +RITG+TKL DAN+AGGRNSEKCTLILTEGDSA  LA+AG+SVVGR++YG
Sbjct: 422  DLKKTDGAKRQRITGITKLEDANDAGGRNSEKCTLILTEGDSAKALAMAGISVVGRNNYG 481

Query: 3357 VFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTDQDHD 3178
            VFPLRGKLLNVR+A+ KQI DNAEIQNIK+ILGLQHGK+YDS+KSLRYGHLMIMTDQDHD
Sbjct: 482  VFPLRGKLLNVREATHKQIMDNAEIQNIKQILGLQHGKEYDSVKSLRYGHLMIMTDQDHD 541

Query: 3177 GSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKRSFYTMPEYESWKESLG 2998
            GSHIKGLLINFIHSFWPSLL+IPSFLVEFITPIVKATHKNG+  SFY+MPEYESWK  LG
Sbjct: 542  GSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHKNGKVLSFYSMPEYESWKX-LG 600

Query: 2997 DKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKKKIEARK 2818
              A  WSIKYYKGLGTST KEGKEYFKDL KHKKDF+W DD DG+AIELAFSKKKIEARK
Sbjct: 601  GNASGWSIKYYKGLGTSTSKEGKEYFKDLHKHKKDFLWVDDRDGDAIELAFSKKKIEARK 660

Query: 2817 NWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRKILFCAF 2638
            NWLRQFEPGT LDQ++KLIKY DFVNKELILFS+ADLQRSIPSMVDGLKPGQRKILFCAF
Sbjct: 661  NWLRQFEPGTCLDQKEKLIKYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFCAF 720

Query: 2637 KRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNGQFGTRN 2458
            KRN + EAKV QF+GYVSEHSAYHHGEQSL STIIGMAQ YVGSNNIN+ +PNGQFGTR+
Sbjct: 721  KRNLIKEAKVAQFSGYVSEHSAYHHGEQSLMSTIIGMAQDYVGSNNINLFQPNGQFGTRH 780

Query: 2457 QGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVVLVNGSE 2278
            QGGKDHASARYI+T+LS ITRFLFPK DDILLDY NEDGQ+IEPTWY+PIIP VLVNGSE
Sbjct: 781  QGGKDHASARYIYTRLSPITRFLFPKGDDILLDYLNEDGQSIEPTWYMPIIPTVLVNGSE 840

Query: 2277 GIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAGATYTVT 2098
            GIGTGWSS++PNYNPRDI+AN++ +L  EPMEPMDPWYKGF+G IEKTATKEAG++YTV+
Sbjct: 841  GIGTGWSSYIPNYNPRDIVANIKRLLNGEPMEPMDPWYKGFKGLIEKTATKEAGSSYTVS 900

Query: 2097 GIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY--------PFIEDVREYHTTDSVNFEI 1942
            GIIEE+++TTLR+TELP+R+WTQDYK+FLES+         PFI+D +E++   +V+FEI
Sbjct: 901  GIIEEINETTLRITELPIRRWTQDYKEFLESIMTGNDKIKEPFIKDYKEHNDDTTVHFEI 960

Query: 1941 DLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSIRFEFY 1762
             LSEEN+ +AKQEGL+KKFKLTTTISTSNMHLFD KG IKKYD PE+ILE+FF +R EFY
Sbjct: 961  ILSEENLMMAKQEGLMKKFKLTTTISTSNMHLFDPKGTIKKYDNPEQILEEFFHLRLEFY 1020

Query: 1761 EKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPFPKKAK 1582
            EKRKK  +DNLE +LL L+NKVRFI+ VV+G+I+VSNR+R DL LEL++KGFTPFPKK K
Sbjct: 1021 EKRKKTQLDNLELDLLKLDNKVRFILGVVKGEIIVSNRKRVDLFLELQQKGFTPFPKKTK 1080

Query: 1581 TTEISVAGSTDVPEETEENSD-MASQGVRASDYDYLLSMSIGSLTIEKVQELCNNRDKLI 1405
              E +VAG+ +  EE EENS+ ++S+GVRASDY+YLLSM+IG+LT+EKVQELC++RDKL 
Sbjct: 1081 ALEAAVAGANEDGEENEENSEVVSSRGVRASDYEYLLSMAIGTLTLEKVQELCSDRDKLN 1140

Query: 1404 QEVEEMRKATINSLWTKDLDALERELDEQDRRDALTEEEAMEIKAKT-----RRASKPAT 1240
             EVEE+RKAT NSLW  DLDALE+ELDEQD+ DA  EE   E+K +       +AS+ A 
Sbjct: 1141 HEVEELRKATPNSLWMNDLDALEKELDEQDKNDAQAEEARKELKNRVMSEAGMKASRQAP 1200

Query: 1239 KNPRKNN-KKISKTESAAEPMEIST-NSEIETVSANIGPFPPSDNARVAVQKKAPRKGKS 1066
            KNPRK N KK S +E+  E +  S+  S +ETV   + P       R    KKAP K  +
Sbjct: 1201 KNPRKTNAKKPSTSETVTESVAASSVGSAMETVPEVVKP-----KGRGGRPKKAPAKKDN 1255

Query: 1065 VAALKDEEDDDEILALNERIAAYNLDSSPDHAEAPEAEVSEVQIKNKGPTRKAAATKKPL 886
            +  +  +EDD +++ L ER+AAYNLDSSP+ +   E EV++V  K K P+++AAA K+P 
Sbjct: 1256 MRLVDSDEDDVDVIELKERLAAYNLDSSPEQSAVMETEVAKVPAKKKEPSKRAAAQKQPS 1315

Query: 885  STV---------------TXXXXXXXXXXXXXXEVIPAEEKKKAGRKPATAKTTKPPVGA 751
            S                                EV  A +  + GRKPA     K     
Sbjct: 1316 SYTEISDDDDGMDVQTIREESIGEIVSDEDFEPEVEEAPKGGRGGRKPAA--NGKAAAST 1373

Query: 750  KKRGPAAKQSQILGQKLITEVL---QGAADSPDKKVRKMRISPFNKKSGSVLGRXXXXXX 580
            KKRG A KQ+ +LGQK IT++L   + A  SP+KKVRKMR SPFNKKSGSVLGR      
Sbjct: 1374 KKRGAANKQTSVLGQKKITDLLKPAENAGVSPEKKVRKMRASPFNKKSGSVLGRVGGMVG 1433

Query: 579  XXXXXXXXXXXXES----------NQVVVPRARPQRANSRKATYVLS----DDDSEDGA 445
                         +          ++VV  R RPQR N  KA YV+S     DD +D A
Sbjct: 1434 DISPMGSEEQQTGTSSASTDSAELSEVVPARPRPQRVNRGKAKYVISSESESDDDDDAA 1492


>ref|XP_010241213.1| PREDICTED: DNA topoisomerase 2-like isoform X1 [Nelumbo nucifera]
          Length = 1504

 Score = 2011 bits (5210), Expect = 0.0
 Identities = 1035/1500 (69%), Positives = 1195/1500 (79%), Gaps = 58/1500 (3%)
 Frame = -1

Query: 4770 KKAPLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHNQTL 4591
            +K PL +SN AN+P            KTIE+TYQKK+QLEHILLRPDTY+GSIEKH QTL
Sbjct: 5    RKLPLQTSNIANVPSSRPLVGSG---KTIEETYQKKSQLEHILLRPDTYVGSIEKHTQTL 61

Query: 4590 WVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVYNNG 4411
            WVY+  +MV +P+TYVPGLYKIFDEILVNAADNKQRDP M+S+KV IDAE NCISVYNNG
Sbjct: 62   WVYDGGEMVHRPVTYVPGLYKIFDEILVNAADNKQRDPSMDSVKVVIDAEQNCISVYNNG 121

Query: 4410 DGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVIETA 4231
            DGVPVEIHQEEGVYVPELIFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEF+IETA
Sbjct: 122  DGVPVEIHQEEGVYVPELIFGHLLTSSNYDDTVKKTTGGRNGYGAKLTNIFSTEFIIETA 181

Query: 4230 DGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVALMKK 4051
            DG+RQ+KYKQVF+ NMG KS+P I+KCK SENWTKVTFKPDL+KFN+THLEDDVVALMKK
Sbjct: 182  DGKRQKKYKQVFSNNMGKKSEPAITKCKGSENWTKVTFKPDLAKFNLTHLEDDVVALMKK 241

Query: 4050 RVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAF--------RIEEKV-DRWEVC 3898
            RVID+AGCLGK VKVELNG+ + V+SF DY NLYL+SA         RI EKV +RWEVC
Sbjct: 242  RVIDLAGCLGKTVKVELNGQRVPVKSFLDYVNLYLQSASKSRPEPLPRITEKVSERWEVC 301

Query: 3897 VSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYVNKKRKNANLKPHSVRNHLW 3718
            VSLS+GQFQQVSFVN I+TIKGGTHVDYVTNQI  H+   VNKK KNANLK H+V+NHLW
Sbjct: 302  VSLSEGQFQQVSFVNGIATIKGGTHVDYVTNQITNHVMTIVNKKNKNANLKAHTVKNHLW 361

Query: 3717 VFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVANSEIVNNILEWAEFKEKK 3538
            VFVN LIDNPAFDSQTKETLT RQ SFGS+C+LS +FL KVA S +V N+L WA+FK+ K
Sbjct: 362  VFVNSLIDNPAFDSQTKETLTTRQSSFGSKCELSQEFLKKVAKSGVVENLLSWADFKQSK 421

Query: 3537 DLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGRDHYG 3358
            DLKKTDG K +RITG+TKL DAN+AGGRNSEKCTLILTEGDSA  LA+AG+SVVGR++YG
Sbjct: 422  DLKKTDGAKRQRITGITKLEDANDAGGRNSEKCTLILTEGDSAKALAMAGISVVGRNNYG 481

Query: 3357 VFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTDQDHD 3178
            VFPLRGKLLNVR+A+ KQI DNAEIQNIK+ILGLQHGK+YDS+KSLRYGHLMIMTDQDHD
Sbjct: 482  VFPLRGKLLNVREATHKQIMDNAEIQNIKQILGLQHGKEYDSVKSLRYGHLMIMTDQDHD 541

Query: 3177 GSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKRSFYTMPEYESWKESLG 2998
            GSHIKGLLINFIHSFWPSLL+IPSFLVEFITPIVKATHKNG+  SFY+MPEYESWK  LG
Sbjct: 542  GSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHKNGKVLSFYSMPEYESWKX-LG 600

Query: 2997 DKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKKKIEARK 2818
              A  WSIKYYKGLGTST KEGKEYFKDL KHKKDF+W DD DG+AIELAFSKKKIEARK
Sbjct: 601  GNASGWSIKYYKGLGTSTSKEGKEYFKDLHKHKKDFLWVDDRDGDAIELAFSKKKIEARK 660

Query: 2817 NWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRKILFCAF 2638
            NWLRQFEPGT LDQ++KLIKY DFVNKELILFS+ADLQRSIPSMVDGLKPGQRKILFCAF
Sbjct: 661  NWLRQFEPGTCLDQKEKLIKYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFCAF 720

Query: 2637 KRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNGQFGTRN 2458
            KRN + EAKV QF+GYVSEHSAYHHGEQSL STIIGMAQ YVGSNNIN+ +PNGQFGTR+
Sbjct: 721  KRNLIKEAKVAQFSGYVSEHSAYHHGEQSLMSTIIGMAQDYVGSNNINLFQPNGQFGTRH 780

Query: 2457 QGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVVLVNGSE 2278
            QGGKDHASARYI+T+LS ITRFLFPK DDILLDY NEDGQ+IEPTWY+PIIP VLVNGSE
Sbjct: 781  QGGKDHASARYIYTRLSPITRFLFPKGDDILLDYLNEDGQSIEPTWYMPIIPTVLVNGSE 840

Query: 2277 GIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAGATYTVT 2098
            GIGTGWSS++PNYNPRDI+AN++ +L  EPMEPMDPWYKGF+G IEKTATKEAG++YTV+
Sbjct: 841  GIGTGWSSYIPNYNPRDIVANIKRLLNGEPMEPMDPWYKGFKGLIEKTATKEAGSSYTVS 900

Query: 2097 GIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY--------PFIEDVREYHTTDSVNFEI 1942
            GIIEE+++TTLR+TELP+R+WTQDYK+FLES+         PFI+D +E++   +V+FEI
Sbjct: 901  GIIEEINETTLRITELPIRRWTQDYKEFLESIMTGNDKIKEPFIKDYKEHNDDTTVHFEI 960

Query: 1941 DLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSIRFEFY 1762
             LSEEN+ +AKQEGL+KKFKLTTTISTSNMHLFD KG IKKYD PE+ILE+FF +R EFY
Sbjct: 961  ILSEENLMMAKQEGLMKKFKLTTTISTSNMHLFDPKGTIKKYDNPEQILEEFFHLRLEFY 1020

Query: 1761 EKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPFPKKAK 1582
            EKRKK  +DNLE +LL L+NKVRFI+ VV+G+I+VSNR+R DL LEL++KGFTPFPKK K
Sbjct: 1021 EKRKKTQLDNLELDLLKLDNKVRFILGVVKGEIIVSNRKRVDLFLELQQKGFTPFPKKTK 1080

Query: 1581 TTEISVAGSTDVPEETEENSD-MASQGVRASDYDYLLSMSIGSLTIEKVQELCNNRDKLI 1405
              E +VAG+ +  EE EENS+ ++S+GVRASDY+YLLSM+IG+LT+EKVQELC++RDKL 
Sbjct: 1081 ALEAAVAGANEDGEENEENSEVVSSRGVRASDYEYLLSMAIGTLTLEKVQELCSDRDKLN 1140

Query: 1404 QEVEEMRKATINSLWTKDLDALERELDEQDRRDALTEEEAMEIKAKT-----RRASKPAT 1240
             EVEE+RKAT NSLW  DLDALE+ELDEQD+ DA  EE   E+K +       +AS+ A 
Sbjct: 1141 HEVEELRKATPNSLWMNDLDALEKELDEQDKNDAQAEEARKELKNRVMSEAGMKASRQAP 1200

Query: 1239 KNPRKNN-KKISKTESAAEPMEIST-NSEIETVSANIGPFPPSDNARVAVQKKAPRKGKS 1066
            KNPRK N KK S +E+  E +  S+  S +ETV   + P       R    KKAP K + 
Sbjct: 1201 KNPRKTNAKKPSTSETVTESVAASSVGSAMETVPEVVKP-----KGRGGRPKKAPAKKQD 1255

Query: 1065 VAALKD-EEDDDEILALNERIAAYNLDSSPDHAEAPEAEVSEVQIKNKGPTRKAAATKKP 889
               L D +EDD +++ L ER+AAYNLDSSP+ +   E EV++V  K K P+++AAA K+P
Sbjct: 1256 NMRLVDSDEDDVDVIELKERLAAYNLDSSPEQSAVMETEVAKVPAKKKEPSKRAAAQKQP 1315

Query: 888  LSTV---------------TXXXXXXXXXXXXXXEVIPAEEKKKAGRKPATAKTTKPPVG 754
             S                                EV  A +  + GRKPA     K    
Sbjct: 1316 SSYTEISDDDDGMDVQTIREESIGEIVSDEDFEPEVEEAPKGGRGGRKPAA--NGKAAAS 1373

Query: 753  AKKRGPAAKQSQILGQKLITEVL---QGAADSPDKKVRKMRISPFNKKSGSVLGRXXXXX 583
             KKRG A KQ+ +LGQK IT++L   + A  SP+KKVRKMR SPFNKKSGSVLGR     
Sbjct: 1374 TKKRGAANKQTSVLGQKKITDLLKPAENAGVSPEKKVRKMRASPFNKKSGSVLGRVGGMV 1433

Query: 582  XXXXXXXXXXXXXES----------NQVVVPRARPQRANSRKATYVLS----DDDSEDGA 445
                          +          ++VV  R RPQR N  KA YV+S     DD +D A
Sbjct: 1434 GDISPMGSEEQQTGTSSASTDSAELSEVVPARPRPQRVNRGKAKYVISSESESDDDDDAA 1493


>ref|XP_007009327.1| DNA topoisomerase 2 isoform 1 [Theobroma cacao]
            gi|508726240|gb|EOY18137.1| DNA topoisomerase 2 isoform 1
            [Theobroma cacao]
          Length = 1473

 Score = 1994 bits (5165), Expect = 0.0
 Identities = 1020/1484 (68%), Positives = 1184/1484 (79%), Gaps = 41/1484 (2%)
 Frame = -1

Query: 4779 MAPKKAPLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHN 4600
            +A  K PL SSNNAN+             KTIE+TYQKKTQLEHILLRPDTYIGSIE+H 
Sbjct: 2    VADSKLPLQSSNNANMKAS----------KTIEETYQKKTQLEHILLRPDTYIGSIEQHT 51

Query: 4599 QTLWVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVY 4420
            Q LWVYE  +MV + I YVPGLYKIFDEILVNAADNKQRDP M+S+KV IDAE N ISVY
Sbjct: 52   QRLWVYENDEMVHRDIKYVPGLYKIFDEILVNAADNKQRDPSMDSVKVVIDAEQNLISVY 111

Query: 4419 NNGDGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVI 4240
            NNGDGVPVE+HQEEGVYVPELIFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEF+I
Sbjct: 112  NNGDGVPVEVHQEEGVYVPELIFGHLLTSSNYDDTVKKTTGGRNGYGAKLTNIFSTEFII 171

Query: 4239 ETADGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVAL 4060
            ETADG+RQ+KYKQVF+ NMG KS+PVISKCKE+ENWTKVTFKPDL+KFNMTHLE+DVVAL
Sbjct: 172  ETADGKRQKKYKQVFSNNMGKKSEPVISKCKEAENWTKVTFKPDLAKFNMTHLEEDVVAL 231

Query: 4059 MKKRVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAF--------RIEEKV-DRW 3907
            MKKRV D+AGCLGK VKVELNG+ + V+SF DY +LYL +A         R+ EKV +RW
Sbjct: 232  MKKRVFDVAGCLGKTVKVELNGKRVPVKSFLDYVSLYLSAASKTKTEPLPRLLEKVNERW 291

Query: 3906 EVCVSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYVNKKRKNANLKPHSVRN 3727
            EV VSLSDGQFQQVSFVN I+TIKGGTHVDYVTNQI+ ++   VNKK KNAN+K H+V+N
Sbjct: 292  EVGVSLSDGQFQQVSFVNGIATIKGGTHVDYVTNQISNYVMNIVNKKNKNANVKAHNVKN 351

Query: 3726 HLWVFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVANSEIVNNILEWAEFK 3547
            HLWVFVN LIDNPAFDSQTKETLTLRQ SFGS+C+LS+ FL KVA   +V+N+L WAEFK
Sbjct: 352  HLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVAKCGVVDNLLSWAEFK 411

Query: 3546 EKKDLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGRD 3367
              KDLKKTDG K+  I G+ KL DAN AGGRNS+KCTLILTEGDSA  LA+AGL+VVGR+
Sbjct: 412  HSKDLKKTDGAKTGSIRGIPKLDDANEAGGRNSDKCTLILTEGDSAKALAVAGLAVVGRN 471

Query: 3366 HYGVFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTDQ 3187
            HYGVFPLRGKLLNVR+AS KQ+ DNAEIQN+K+ILGLQ GK+Y ++KSLRYGHLMIMTDQ
Sbjct: 472  HYGVFPLRGKLLNVREASHKQLMDNAEIQNLKRILGLQQGKEYSNVKSLRYGHLMIMTDQ 531

Query: 3186 DHDGSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKRSFYTMPEYESWKE 3007
            DHDGSHIKGLLINFIHSFWPSLL++PSF+VEFITPIVKATHK     SFY+MPEYE WKE
Sbjct: 532  DHDGSHIKGLLINFIHSFWPSLLKVPSFMVEFITPIVKATHKTKGVLSFYSMPEYEFWKE 591

Query: 3006 SLGDKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKKKIE 2827
            SLG  A+ WSIKYYKGLGTST KEGK+YFK+L+KH+K+FVW D+ DGEAIELAFSKKKIE
Sbjct: 592  SLGGNAKGWSIKYYKGLGTSTSKEGKDYFKNLDKHRKEFVWQDEQDGEAIELAFSKKKIE 651

Query: 2826 ARKNWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRKILF 2647
            ARKNWLRQFEPGT+LDQ  KLIKY +F+NKELILFS+ADLQRSIPSM+DGLKPGQRKILF
Sbjct: 652  ARKNWLRQFEPGTHLDQSQKLIKYSEFINKELILFSMADLQRSIPSMIDGLKPGQRKILF 711

Query: 2646 CAFKRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNGQFG 2467
            C+FKRNFV EAKV QF+GYVSEHSAYHHGEQSLASTI+GMAQ +VGSNNIN+L P GQFG
Sbjct: 712  CSFKRNFVKEAKVAQFSGYVSEHSAYHHGEQSLASTIVGMAQDFVGSNNINLLNPGGQFG 771

Query: 2466 TRNQGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVVLVN 2287
            TRNQGGKD ASARYIFT LS ITR+LFPKDDD LLDY NEDGQ+IEP WYVPIIP+VLVN
Sbjct: 772  TRNQGGKDAASARYIFTNLSPITRYLFPKDDDGLLDYLNEDGQSIEPIWYVPIIPMVLVN 831

Query: 2286 GSEGIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAGATY 2107
            GSEGIGTGWSS++PNYNPRDI+ANVR +L  E MEPM PWY+GF+G IEKTA+KEAG TY
Sbjct: 832  GSEGIGTGWSSYIPNYNPRDIVANVRRLLNGEQMEPMHPWYRGFKGNIEKTASKEAGVTY 891

Query: 2106 TVTGIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY----PFIEDVREYHTTDSVNFEID 1939
            T+TGIIEEV +TTLR+TELPVR+WTQDY++FLES+     PFI++ R+Y    +V FE+ 
Sbjct: 892  TITGIIEEVDETTLRITELPVRRWTQDYREFLESIITGNDPFIKEFRQYSDDTTVEFEVI 951

Query: 1938 LSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSIRFEFYE 1759
            L+EENM +AKQEGLLKKFKLTTTISTSNMHLFDSKG+IKKYDTPE+ILE+FF +RFEFYE
Sbjct: 952  LTEENMMVAKQEGLLKKFKLTTTISTSNMHLFDSKGMIKKYDTPEQILEEFFHLRFEFYE 1011

Query: 1758 KRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPFPKKAKT 1579
            KRKK L+DNLE ELL +ENKVRFI+ VV+G+I+V+NR+RADL LEL+ KGFTPFPKKAKT
Sbjct: 1012 KRKKLLLDNLEMELLKMENKVRFILGVVKGEIIVNNRKRADLFLELQTKGFTPFPKKAKT 1071

Query: 1578 TEISVAGSTDVPEETEENSDMASQGVRASDYDYLLSMSIGSLTIEKVQELCNNRDKLIQE 1399
             E++VAG+TD  EETEENS+++++G++ASDYDYLLSM+IGSLT+EKVQELC +RDKL QE
Sbjct: 1072 VEVAVAGATDDTEETEENSEVSAKGLQASDYDYLLSMAIGSLTLEKVQELCADRDKLQQE 1131

Query: 1398 VEEMRKATINSLWTKDLDALERELDEQDRRDALTEEEAMEIKAK---TRRASKPATKNPR 1228
            VE++RKAT  SLW KDLD LE +LDEQD+  A  EE A  +K +    +RA + A K PR
Sbjct: 1132 VEDLRKATPKSLWLKDLDNLEIQLDEQDKA-AQAEEAAKLVKGRGEAGKRAQRQAPKIPR 1190

Query: 1227 KNNKKISKTESAAEPMEISTNSEIETVSANIGPFPPSDNARVAVQKKAPRKGKSVAALKD 1048
            K NKK    E+  E  +IS++S +ET           + A  AV+ K   +G S  A KD
Sbjct: 1191 KINKKEKNAETVTETTDISSSSAMET-----------ETAPAAVKPKG--RGGSRKAKKD 1237

Query: 1047 EEDDDE-----ILALNERIAAYNLDSSPDHAEAPEAEVSEVQIKNKGPTRKAAATKKPLS 883
            + DDD+     I  L ER+A YNLDSSPDH+ A E EV +V    K P+++AAA +K  +
Sbjct: 1238 DSDDDDDEDFGIPDLRERLAKYNLDSSPDHSAAMETEVPQVPAGKKEPSKRAAAARKKPA 1297

Query: 882  T--------VTXXXXXXXXXXXXXXEVIPAEEKKKAGRKPA--TAKTTKPPVGAKKRGPA 733
            T        +                   A   KK GRKPA  +    KPP  AKKRGPA
Sbjct: 1298 TSLSEISESIGEIDINDEDLEVVEVAAAAAPAGKKGGRKPAANSKAAAKPPAAAKKRGPA 1357

Query: 732  AKQSQILGQKLITEVLQGAAD---SPDKKVRKMRISPFNKKSGSVLGRXXXXXXXXXXXX 562
            A   +   QKL+TE+L+ A D   SP+KKVRKMR SPFNKKSGSVLGR            
Sbjct: 1358 AAGKKSQQQKLLTEMLKPAEDSGISPEKKVRKMRASPFNKKSGSVLGRVGKELESTTDSE 1417

Query: 561  XXXXXXESN-------QVVVPRARPQRANSRKATYVLSDDDSED 451
                    +       ++V  R RPQR N ++ TYVLSD ++++
Sbjct: 1418 ETFGSSSMSADTEEVTEIVPARPRPQRTNRKQTTYVLSDSETDN 1461


>ref|XP_006345427.1| PREDICTED: DNA topoisomerase 2-like [Solanum tuberosum]
          Length = 1485

 Score = 1979 bits (5127), Expect = 0.0
 Identities = 1008/1477 (68%), Positives = 1178/1477 (79%), Gaps = 34/1477 (2%)
 Frame = -1

Query: 4779 MAPKKAPLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHN 4600
            MA KK PL SS+NANI             KTIEQTYQKKTQLEHILLRPDTYIGS+EKH 
Sbjct: 1    MATKKLPLQSSSNANIS--------NANGKTIEQTYQKKTQLEHILLRPDTYIGSVEKHT 52

Query: 4599 QTLWVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVY 4420
            QTLWV+E   MV +P+TYVPGLYKIFDEILVNAADNKQRDPKM++L+V ID E N +SVY
Sbjct: 53   QTLWVWENDAMVHRPVTYVPGLYKIFDEILVNAADNKQRDPKMDALEVVIDPEQNLVSVY 112

Query: 4419 NNGDGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVI 4240
            NNGDG+PVEIHQEEGVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEF+I
Sbjct: 113  NNGDGIPVEIHQEEGVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFII 172

Query: 4239 ETADGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVAL 4060
            ETADG+RQ+KYKQVF+ NMG K +P+I+KCK SENWTKV+FKPDL+KFNM  LE DVVAL
Sbjct: 173  ETADGKRQKKYKQVFSNNMGKKGEPIITKCKASENWTKVSFKPDLAKFNMEELEADVVAL 232

Query: 4059 MKKRVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAFRIEE--KVD------RWE 3904
            M+KRVID+ GCLGK VKV+LN + I V+SF +YC L+L S     E  KV+      RWE
Sbjct: 233  MRKRVIDLGGCLGKTVKVKLNEQRIPVKSFEEYCKLFLDSNDVKREFLKVNDANGVLRWE 292

Query: 3903 VCVSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYVNKKRKNANLKPHSVRNH 3724
            +CVSLS+GQFQQVSFVNSI+TIKGGTHVDYV NQIA H+   VN+K KNAN+K H+V+NH
Sbjct: 293  ICVSLSEGQFQQVSFVNSIATIKGGTHVDYVANQIANHIMGVVNRKNKNANIKAHAVKNH 352

Query: 3723 LWVFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVA-NSEIVNNILEWAEFK 3547
            LW+FVN LIDNPAFDSQTKETLTLRQ SFGS+C+L   FL KV  N  IV+++L WA+FK
Sbjct: 353  LWMFVNALIDNPAFDSQTKETLTLRQSSFGSKCELQPDFLKKVEKNIGIVDSLLSWADFK 412

Query: 3546 EKKDLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGRD 3367
              KDLKKTDG KS ++  + KL DAN+AGGRNS+KCTLILTEGDSA  LA+AG+SVVGRD
Sbjct: 413  NSKDLKKTDGKKSDKVK-VEKLEDANDAGGRNSDKCTLILTEGDSAKALAMAGISVVGRD 471

Query: 3366 HYGVFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTDQ 3187
            HYGVFPLRGKLLNVR+AS KQ+++N EI++IKKILGLQ GK+Y+S+KSLRYGHLMIMTDQ
Sbjct: 472  HYGVFPLRGKLLNVREASHKQVSENKEIESIKKILGLQTGKEYESVKSLRYGHLMIMTDQ 531

Query: 3186 DHDGSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKRSFYTMPEYESWKE 3007
            DHDGSHIKGLLINFIH+FWPSLL++PSFLVEFITPIVKATHK+G   +FYTMPEYE+W+ 
Sbjct: 532  DHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSGRILAFYTMPEYEAWRR 591

Query: 3006 SLGDKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKKKIE 2827
            SLG  +  WSIKYYKGLGTST KEGKEYF+DL+KH+KDF+WAD+ DGE+IELAFSKKKIE
Sbjct: 592  SLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADNQDGESIELAFSKKKIE 651

Query: 2826 ARKNWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRKILF 2647
            ARKNWLRQFEPGT+LDQ++K I Y +FVNKELILFS+ADLQRSIPSM+DGLKPGQRKILF
Sbjct: 652  ARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIPSMLDGLKPGQRKILF 711

Query: 2646 CAFKRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNGQFG 2467
            CAFKRNFV EAKV QF+GYVSEHSAYHHGEQSL+STIIGMAQ YVGSNN+N+L+PNGQFG
Sbjct: 712  CAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYVGSNNVNLLQPNGQFG 771

Query: 2466 TRNQGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVVLVN 2287
            TRN GGKDHAS+RYI+T+LS I RFLFPKDDD +LDY NEDGQ+IEPTWY+PIIP+VLVN
Sbjct: 772  TRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTVLDYLNEDGQSIEPTWYIPIIPMVLVN 831

Query: 2286 GSEGIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAGATY 2107
            GSEGIGTGWSS+VPNYNPRD++ANVR +L DE MEPMDPWYKGF+GTIEKTATKE GATY
Sbjct: 832  GSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGFKGTIEKTATKETGATY 891

Query: 2106 TVTGIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY--------PFIEDVREYHTTDSVN 1951
            TVTGIIEE S+TTLR++ELPVR+WT+DYK FLES+          FI++VR Y   +SV 
Sbjct: 892  TVTGIIEEFSETTLRISELPVRRWTEDYKQFLESMTVSTDKSKDAFIKEVRAYGDENSVC 951

Query: 1950 FEIDLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSIRF 1771
            FE+ +SEEN+ +A+QEGLLKKFKLTTTISTSNMHLFDSKG IKKYD PE+ILE+F+ +R 
Sbjct: 952  FEVIMSEENLLLAQQEGLLKKFKLTTTISTSNMHLFDSKGKIKKYDAPEEILEEFYHVRL 1011

Query: 1770 EFYEKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPFPK 1591
            E+YEKRKK L++ LE ELL +ENKVRFI+ VV+G+I+V+NR+RADL+LELK KGFTPFPK
Sbjct: 1012 EYYEKRKKTLLEILELELLRIENKVRFILGVVKGEIIVNNRKRADLLLELKNKGFTPFPK 1071

Query: 1590 KAKTTEISVAGSTDVPEETEENSDMASQGVRASDYDYLLSMSIGSLTIEKVQELCNNRDK 1411
            K K  E  VA STD  E++EE+ + +++GVRASDYDYLLSM+IG+LT+EKVQELC +RDK
Sbjct: 1072 K-KPVEAVVADSTDDAEDSEESPEESNKGVRASDYDYLLSMAIGTLTLEKVQELCADRDK 1130

Query: 1410 LIQEVEEMRKATINSLWTKDLDALERELDEQDRRDALTEEEAMEIKAKTRRASKPATK-N 1234
            L  EVE+MR AT   LW KDLD L+++LDEQD+ D  TEE   ++K K   A+  A K  
Sbjct: 1131 LNAEVEDMRNATPKDLWMKDLDVLDKQLDEQDKLDIQTEEAREKLKKKVMNAAGKAPKPK 1190

Query: 1233 PRKNNKKISKTESAAEPMEISTNSEIETVSANIGPFPPSDNARVAVQKKAPRKGKSVAAL 1054
            PRK  KK +  ES AEPM++S  S  ET +      P     R    KKAP K K V  +
Sbjct: 1191 PRKTTKKAAVVESTAEPMDVSVGSMAETANVTEVAKP---KGRGGGSKKAPAKAKPV-VV 1246

Query: 1053 KDEEDDDEILALNERIAAYNLDSSPDHAEAPEAEVSEVQIKNKGPTRKAAATKKPLSTVT 874
            +DEE++DE+LAL +R+AAYNL+SSPD +E  E E  + Q   K P ++AAA KK L +  
Sbjct: 1247 EDEEEEDEVLALKDRLAAYNLNSSPDRSEVTETEAPKAQ--TKAPAKRAAAQKKALPSTP 1304

Query: 873  XXXXXXXXXXXXXXEVIPAE----EKKKAGRKPATAKTTKPPVGAKKRGPAAKQSQILGQ 706
                               E     KKK GRKPA AK    P   KKR PA KQSQ +GQ
Sbjct: 1305 DVSEGEDEIEISDDNEFAPEVAVGGKKKGGRKPAAAKAAAAPKPPKKRAPANKQSQSVGQ 1364

Query: 705  KLITEVLQGAAD---SPDKKVRKMRISPFNKKSGSVLGR---------XXXXXXXXXXXX 562
            +LIT+VL+ A D   SPD+KVRKMR SPFNKKSG+V+GR                     
Sbjct: 1365 RLITQVLKPAEDAGVSPDRKVRKMRESPFNKKSGAVMGRNTSSSSSTSHESEVSPPIPSL 1424

Query: 561  XXXXXXESNQVVVPRARPQRANSRKATYVLSDDDSED 451
                   S  VV P+ARPQRAN  K TYV+SD DSE+
Sbjct: 1425 GSLEEEVSEVVVAPKARPQRANRTKTTYVISDSDSEE 1461


>ref|XP_010257162.1| PREDICTED: LOW QUALITY PROTEIN: DNA topoisomerase 2-like [Nelumbo
            nucifera]
          Length = 1489

 Score = 1978 bits (5125), Expect = 0.0
 Identities = 1014/1496 (67%), Positives = 1174/1496 (78%), Gaps = 56/1496 (3%)
 Frame = -1

Query: 4770 KKAPLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHNQTL 4591
            KK PL +SNN N+             KTIE+TYQKK+QLEHILLRPDTYIGSIEKH QTL
Sbjct: 5    KKFPLQTSNNVNVASSRPPVAPG---KTIEETYQKKSQLEHILLRPDTYIGSIEKHTQTL 61

Query: 4590 WVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVYNNG 4411
            WVYE  +MV +P+TYVPGLYKIFDEILVNAADNKQRDP M+S+KV ID E NCISVYNNG
Sbjct: 62   WVYEGGEMVHRPVTYVPGLYKIFDEILVNAADNKQRDPSMDSVKVDIDVEQNCISVYNNG 121

Query: 4410 DGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVIETA 4231
            DGVPVEIHQEEGVYVPE+IFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEF+I+TA
Sbjct: 122  DGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDTVKKTTGGRNGYGAKLTNIFSTEFIIQTA 181

Query: 4230 DGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVALMKK 4051
            DGRRQ+KYKQVF+ NMG KS+P I+KCKE ENWTKVTFKPDL+KFNMTHLEDDV+ALMKK
Sbjct: 182  DGRRQKKYKQVFSNNMGKKSEPTITKCKEGENWTKVTFKPDLAKFNMTHLEDDVLALMKK 241

Query: 4050 RVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAF--------RIEEKV-DRWEVC 3898
            RVID+AGCLGK VKVELNG+ + V+SF DY NLYL+SA         RI EKV +RWE+C
Sbjct: 242  RVIDLAGCLGKTVKVELNGQRVPVKSFLDYVNLYLQSASKTRPESLPRITEKVNERWEIC 301

Query: 3897 VSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYVNKKRKNANLKPHSVRNHLW 3718
            VSLS+GQFQQVSFVN I+TIKGGTHVDYVTNQI  H+   VNKK KNANLK H+V+NHLW
Sbjct: 302  VSLSEGQFQQVSFVNGIATIKGGTHVDYVTNQITNHVMTIVNKKNKNANLKAHTVKNHLW 361

Query: 3717 VFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVANSEIVNNILEWAEFKEKK 3538
            VFVN LIDNPAFDSQTKETLT RQ SFGS+C+LS +FL KVA S +V N+L WA+FK+ K
Sbjct: 362  VFVNALIDNPAFDSQTKETLTTRQNSFGSKCELSQEFLKKVAKSGVVENLLSWADFKQSK 421

Query: 3537 DLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGRDHYG 3358
            DLKKTDG K +RITG+TKL DAN+AGG+NSEKCTLILTEGDSA  LA+AG+SVVGR+HYG
Sbjct: 422  DLKKTDGAKRQRITGITKLEDANDAGGKNSEKCTLILTEGDSAKALAMAGISVVGRNHYG 481

Query: 3357 VFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTDQDHD 3178
            VFPLRGKLLNVR+A+ KQI +NAEIQNIK+ILGLQHGK+YDS+KSLRYGHLMIMTDQDHD
Sbjct: 482  VFPLRGKLLNVREANHKQIMENAEIQNIKQILGLQHGKEYDSVKSLRYGHLMIMTDQDHD 541

Query: 3177 GSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKRSFYTMPEYESWKESLG 2998
            GSHIKGLLINFIH+FWPSLL+IPSFLVEFITP+VKA HKNG   SFY+MPEYESWKESL 
Sbjct: 542  GSHIKGLLINFIHTFWPSLLKIPSFLVEFITPVVKAIHKNGRVLSFYSMPEYESWKESLA 601

Query: 2997 DKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKKKIEARK 2818
              A  WSIKYYKGLGTST KEGKEYFKDL+ HKKDF+W ++ DG+AIELAFSKKKIEARK
Sbjct: 602  GNASGWSIKYYKGLGTSTSKEGKEYFKDLDMHKKDFIWINEQDGDAIELAFSKKKIEARK 661

Query: 2817 NWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRKILFCAF 2638
            NWLR FEPGTYLDQ++K IKY DFVNKELILFS+ADLQRSIPSMVDGLKPGQRKILFCAF
Sbjct: 662  NWLRNFEPGTYLDQKEKFIKYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFCAF 721

Query: 2637 KRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNGQFGTRN 2458
            KRNF+ EAKV QF+GYVSEHSAYHHGEQSL STIIGMAQ YVGSNNIN+ +PNGQFGTR+
Sbjct: 722  KRNFIKEAKVAQFSGYVSEHSAYHHGEQSLMSTIIGMAQDYVGSNNINLFQPNGQFGTRH 781

Query: 2457 QGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVVLVNGSE 2278
            QGGKDHASARYI+T+LS ITRFLFPKDDDILLDY NEDGQ+IEPTWY+PI+P+VLVNGSE
Sbjct: 782  QGGKDHASARYIYTRLSPITRFLFPKDDDILLDYLNEDGQSIEPTWYMPIVPMVLVNGSE 841

Query: 2277 GIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAGATYTVT 2098
            GIGTGWSS++PNYNPRDI+AN+R +L  EPME MDPWYKGFRG IEKTATKEAG++YTV+
Sbjct: 842  GIGTGWSSYIPNYNPRDIVANIRRLLNGEPMEAMDPWYKGFRGLIEKTATKEAGSSYTVS 901

Query: 2097 GIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY--------PFIEDVREYHTTDSVNFEI 1942
            GIIE+  D                 K+FLES+         PFI+D RE++   +V+FE+
Sbjct: 902  GIIEDXDD-----------------KEFLESIMTGNDKIKEPFIKDYREHNDDTTVHFEV 944

Query: 1941 DLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSIRFEFY 1762
             LSEEN++ AKQEGL+KKFKLTTTISTSNMHLFD KGVIKKYD PE+ILE+FF +R EFY
Sbjct: 945  ILSEENLQAAKQEGLMKKFKLTTTISTSNMHLFDPKGVIKKYDNPEQILEEFFHLRLEFY 1004

Query: 1761 EKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPFPKKAK 1582
            EKRKK L+DNLE +LL L+NKVRFI+ VV+G+I+VSNR+RADL LEL++KGFTPFPKK K
Sbjct: 1005 EKRKKVLLDNLELDLLKLDNKVRFILGVVKGEIIVSNRKRADLFLELQQKGFTPFPKKTK 1064

Query: 1581 TTEISVAGSTDVPEETEENSD-MASQGVRASDYDYLLSMSIGSLTIEKVQELCNNRDKLI 1405
            T E++VAG+T+  EE EENS+ ++S+GVRASDY+YLLSM+IG+LT+EKVQELC + +KL 
Sbjct: 1065 TVEVAVAGATEDAEENEENSEVVSSKGVRASDYEYLLSMAIGTLTLEKVQELCADSNKLN 1124

Query: 1404 QEVEEMRKATINSLWTKDLDALERELDEQDRRDALTEEEAMEIKAKTR-----RASKPAT 1240
             EV+E+RKAT  +LW +DLDALE+ELDEQD+ DA  E+   E+K++       + S+ A 
Sbjct: 1125 HEVDELRKATPKTLWLRDLDALEKELDEQDKNDAQAEDARKELKSRVMSDAGLKVSRQAP 1184

Query: 1239 KNPRKNN-KKISKTESAAEPMEISTNSEIETVSANIGPFPPSDNARVAVQKKAPRKGKSV 1063
            KNPRK N KK +  E  AE +  S  S +ET   N+         R    K + +K   +
Sbjct: 1185 KNPRKTNAKKNNNLEPVAESVAASVGSAMET--GNVAEV-AKPKGRGGPMKASAKKQDQL 1241

Query: 1062 AALKDEEDDDEILALNERIAAYNLDSSPDHAEAPEAEVSE-VQIKNKGPTRKAAATKK-- 892
            A    +EDD+++L L ER+AAYNLDSSPD + A E EV++    + KGP++ AAA KK  
Sbjct: 1242 ALADSDEDDEDVLELKERLAAYNLDSSPDQSAAMETEVAKPPAARKKGPSKMAAAQKKHP 1301

Query: 891  ------------PLSTVTXXXXXXXXXXXXXXEVIPAEEKKKAGRKPATAK----TTKPP 760
                         + T+               E       KK GRKPA AK      KP 
Sbjct: 1302 SSYTENSDDDDVTMHTIEENMRENGNDEDFEPEAAGPRGGKKGGRKPAAAKVKTAAAKPT 1361

Query: 759  VGAKKRGPAAKQSQILGQKLITEVLQ---GAADSPDKKVRKMRISPFNKKSGSVLGRXXX 589
               KKRGPA KQ  +L QKLITEVL+    +  SP+KKVRKMR  PFN+KS SVLGR   
Sbjct: 1362 AATKKRGPANKQPSLLSQKLITEVLKPVDNSGVSPEKKVRKMRAFPFNRKSASVLGRVSG 1421

Query: 588  XXXXXXXXXXXXXXXESN----------QVVVPRARPQRANSRKATYVLSDDDSED 451
                            S+            VV R RPQRAN  KA YVLSD +S+D
Sbjct: 1422 KVGEVSPKLSEEEPGSSSGSASTNTEEVSEVVARPRPQRANRGKARYVLSDSESDD 1477


>ref|XP_009800897.1| PREDICTED: LOW QUALITY PROTEIN: DNA topoisomerase 2-like [Nicotiana
            sylvestris]
          Length = 1474

 Score = 1959 bits (5076), Expect = 0.0
 Identities = 1004/1478 (67%), Positives = 1174/1478 (79%), Gaps = 36/1478 (2%)
 Frame = -1

Query: 4779 MAPKKAPLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHN 4600
            MA KK PL SS+NANI             KTIEQTYQKKTQLEHILLRPDTYIGS+EKH 
Sbjct: 1    MASKKLPLQSSSNANIATNG---------KTIEQTYQKKTQLEHILLRPDTYIGSVEKHT 51

Query: 4599 QTLWVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVY 4420
            QTLWV+E  +M  +P+TYVPGLYKIFDEILVNAADNKQRDPKM++++V ID E N ISVY
Sbjct: 52   QTLWVWENDKMTHRPVTYVPGLYKIFDEILVNAADNKQRDPKMDAVEVVIDPEQNFISVY 111

Query: 4419 NNGDGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVI 4240
            NNGDG+PVEIHQEEGVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVI
Sbjct: 112  NNGDGIPVEIHQEEGVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVI 171

Query: 4239 ETADGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVAL 4060
            ETADG+RQ+KYKQVF+ NMG K +P+I+KCK SENWTKV+FKPDL+KFNM HLE+DVVAL
Sbjct: 172  ETADGKRQKKYKQVFSSNMGKKGEPIITKCKASENWTKVSFKPDLAKFNMEHLEEDVVAL 231

Query: 4059 MKKRVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAFRIEEKVD--------RWE 3904
            M+KRVID+ GCLGK VKV+LN + I V+SF +YC L+L S     E +         RWE
Sbjct: 232  MRKRVIDLGGCLGKTVKVKLNEQRIPVKSFEEYCKLFLDSTDAKREFLKVTDADGLLRWE 291

Query: 3903 VCVSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYVNKKRKNANLKPHSVRNH 3724
            +CVSLS+GQFQQVSFVNSI+TIKGGTHVDYV NQIA H+   VNKK KNAN+K H+V+NH
Sbjct: 292  ICVSLSEGQFQQVSFVNSIATIKGGTHVDYVANQIANHIMGVVNKKNKNANIKAHAVKNH 351

Query: 3723 LWVFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVA-NSEIVNNILEWAEFK 3547
            LW+FVN LIDNPAFDSQTKETLTLRQ SFGS+C+L   FL KV  N  IV  +L WA+FK
Sbjct: 352  LWMFVNALIDNPAFDSQTKETLTLRQSSFGSKCELQPDFLKKVEKNIGIVETLLSWADFK 411

Query: 3546 EKKDLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGRD 3367
              KDLKKTDG KS+++  + KL DAN+AGGRNSEKCTLILTEGDSA  LA+AG+SVVGRD
Sbjct: 412  NSKDLKKTDGKKSEKVK-VEKLEDANDAGGRNSEKCTLILTEGDSAKALAMAGISVVGRD 470

Query: 3366 HYGVFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTDQ 3187
            HYGVFPLRGKLLNVR+AS KQ+++N EI+ IKKILGLQ GK+YDS+KSLRYGHLMIMTDQ
Sbjct: 471  HYGVFPLRGKLLNVREASHKQVSENKEIEAIKKILGLQTGKEYDSVKSLRYGHLMIMTDQ 530

Query: 3186 DHDGSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKRSFYTMPEYESWKE 3007
            DHDGSHIKGLLINFIH+FWPSLL++PSFL+EFITPIVKATHK+G+  SFYTMPEYESW++
Sbjct: 531  DHDGSHIKGLLINFIHTFWPSLLKVPSFLIEFITPIVKATHKSGKILSFYTMPEYESWRK 590

Query: 3006 SLGDKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKKKIE 2827
            SLG  +  WSIKYYKGLGTST KEGKEYF+DL+KH+KDF+WAD+ DGE+IELAFSKKKIE
Sbjct: 591  SLGANSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADNQDGESIELAFSKKKIE 650

Query: 2826 ARKNWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRKILF 2647
            ARKNWLRQFEPGT+LDQ++K I Y +FVNKELILFS+ADLQRSIPSM+DGLKPGQRKILF
Sbjct: 651  ARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIPSMLDGLKPGQRKILF 710

Query: 2646 CAFKRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNGQFG 2467
            CAFKRNFV EAKV QF+GYVSEHSAYHHGEQSL+STIIGMAQ YVGSNN+N+L+PNGQFG
Sbjct: 711  CAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYVGSNNVNLLQPNGQFG 770

Query: 2466 TRNQGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVVLVN 2287
            TRN GGKDHAS+RYI+T+LS I RFLFPK+DD +LDY NEDGQ+IEPTWYVPI+P+VL+N
Sbjct: 771  TRNMGGKDHASSRYIYTRLSPIARFLFPKEDDTILDYLNEDGQSIEPTWYVPIVPMVLIN 830

Query: 2286 GSEGIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAGATY 2107
            GSEGIGTGWSS+VPNYNPRD++ANVR +L DEPMEPMDPWYKGF+GTIEKTATKEAGATY
Sbjct: 831  GSEGIGTGWSSYVPNYNPRDLVANVRRLLNDEPMEPMDPWYKGFKGTIEKTATKEAGATY 890

Query: 2106 TVTGIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY--------PFIEDVREYHTTDSVN 1951
            TVTGIIEE+++TTLR++ELPVR+WT+DYK FLES+         PFI++VR Y   +SV 
Sbjct: 891  TVTGIIEELNETTLRISELPVRRWTEDYKQFLESMTVSNDKAKDPFIKEVRAYGDENSVC 950

Query: 1950 FEIDLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSIRF 1771
            FE+ LSEEN+ +A+QEGLLKKFKL TTISTSNMHLFDSKG IKKYD PE ILE+F+ +R 
Sbjct: 951  FEVILSEENLILAQQEGLLKKFKLATTISTSNMHLFDSKGKIKKYDNPEDILEEFYHVRL 1010

Query: 1770 EFYEKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPFPK 1591
            E+YEKRK+AL++ LE ELL +ENKV+FI+ VV+G+I+V+NR+RADL+LELKEKGFTPFPK
Sbjct: 1011 EYYEKRKRALLEILELELLRIENKVKFILGVVKGEIIVNNRKRADLLLELKEKGFTPFPK 1070

Query: 1590 KAKTTEISVAGSTDVPEETEENSDMASQGVRASDYDYLLSMSIGSLTIEKVQELCNNRDK 1411
            K K  E  VA ++D  E++EE     ++GVRA DYDYLLSM+IG+LT+EKVQELC  RDK
Sbjct: 1071 K-KAVEAVVADTSDDAEDSEEE---LNRGVRAGDYDYLLSMAIGTLTLEKVQELCAERDK 1126

Query: 1410 LIQEVEEMRKATINSLWTKDLDALERELDEQDRRDALTEEEAMEIKAKTRRAS--KPATK 1237
            L  EVE+MR AT   LW KDLD LE++LDEQD+ D  TEE   +IK K   A+  K    
Sbjct: 1127 LNGEVEDMRNATPKLLWLKDLDVLEKQLDEQDKIDIQTEEAREKIKKKVMNAAGLKAPKP 1186

Query: 1236 NPRKNNKKISKTESAAEPME-ISTNSEIETVSANIGPFPPSDNARVAVQKKAPRKGKSVA 1060
             PRKN KK S  ES AEPM+ +S  ++   + +N               KKAP K K +A
Sbjct: 1187 KPRKNVKKASVVESTAEPMDXVSCFNKGNRLVSNSNVTEVVKPKARGGSKKAPAKAKPIA 1246

Query: 1059 ALKDEEDDDEILALNERIAAYNLDSSPDHA-EAPEAEVSEVQIKNKGPTRKAAATKKPLS 883
               +EE+DDE+LAL +R+AAYNL+SSPDH+ E  E E  + Q   K PTRKAAA KK L 
Sbjct: 1247 VEDEEEEDDEVLALKDRLAAYNLNSSPDHSTEGMETEAPKAQ--KKAPTRKAAAKKKTLP 1304

Query: 882  TVTXXXXXXXXXXXXXXEVIPAE----EKKKAGRKPATAKTTKPPVGAKKRGPAAKQSQI 715
            ++               +    E     KKK GRK A A T +PP   KKRGP  KQS  
Sbjct: 1305 SIADVSEGEDEIEISDDDEFEPEVAVGGKKKGGRKAAPAATKQPP---KKRGPGNKQSVG 1361

Query: 714  LGQKLITEVLQGAAD----SPDKKVRKMRISPFNKKSGSVLGR-------XXXXXXXXXX 568
            +GQKLIT +L+ A +    SP+KKVRKMR SPFNKKSGSVLG+                 
Sbjct: 1362 IGQKLITSILKPAENTDNSSPEKKVRKMRASPFNKKSGSVLGKNKEGSTSQENEDVSPVS 1421

Query: 567  XXXXXXXXESNQVVVPRARPQRANSRKATYVLSDDDSE 454
                     +  VV P+AR  R   +K TYV+SD D+E
Sbjct: 1422 SLGSLEDEVNEAVVAPKARVTR--GKKTTYVISDSDNE 1457


>ref|XP_009630917.1| PREDICTED: LOW QUALITY PROTEIN: DNA topoisomerase 2-like [Nicotiana
            tomentosiformis]
          Length = 1486

 Score = 1956 bits (5066), Expect = 0.0
 Identities = 1010/1485 (68%), Positives = 1179/1485 (79%), Gaps = 42/1485 (2%)
 Frame = -1

Query: 4779 MAPKKAPLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHN 4600
            MA KK PL SS+NANI             KTIEQTYQKKTQLEHILLRPDTYIGS+EKH 
Sbjct: 1    MASKKLPLQSSSNANIVTNG---------KTIEQTYQKKTQLEHILLRPDTYIGSVEKHT 51

Query: 4599 QTLWVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVY 4420
            QTLWV+E  +M+ +P+TYVPGLYKIFDEILVNAADNKQRDPKM++++V ID E N ISVY
Sbjct: 52   QTLWVWENDKMIHRPVTYVPGLYKIFDEILVNAADNKQRDPKMDAVEVVIDPEQNFISVY 111

Query: 4419 NNGDGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVI 4240
            NNGDG+PVEIHQEEGVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVI
Sbjct: 112  NNGDGIPVEIHQEEGVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVI 171

Query: 4239 ETADGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVAL 4060
            ETADG+RQ+KYKQVF+ NMG K +P+I+KCK SENWTKV+FKPDL+KFNM HLE+DVVAL
Sbjct: 172  ETADGKRQKKYKQVFSNNMGKKGEPIITKCKASENWTKVSFKPDLAKFNMEHLEEDVVAL 231

Query: 4059 MKKRVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAFRIEEKVD--------RWE 3904
            M+KRVID+ GCLGK VKV+LN + I V+SF +YC L+L S     E +         RWE
Sbjct: 232  MRKRVIDLGGCLGKTVKVKLNEQRIPVKSFEEYCKLFLDSTDAKREFLKVTDADGLLRWE 291

Query: 3903 VCVSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYVNKKRKNANLKPHSVRNH 3724
            +CVSLS+GQFQQVSFVNSI+TIKGGTHVDYV NQIA+H+   VNKK KNAN+K H+V+NH
Sbjct: 292  ICVSLSEGQFQQVSFVNSIATIKGGTHVDYVANQIASHIMGVVNKKNKNANIKAHAVKNH 351

Query: 3723 LWVFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVA-NSEIVNNILEWAEFK 3547
            LW+FVN LIDNPAFDSQTKETLTLRQ SFGS+C+L   FL KV  N  IV  +L WA+FK
Sbjct: 352  LWMFVNALIDNPAFDSQTKETLTLRQSSFGSKCELQQDFLKKVEKNIGIVETLLSWADFK 411

Query: 3546 EKKDLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGRD 3367
              KDLKKTDG KS+++  + KL DAN+AGGRNS+KCTLILTEGDSA  LA+AG+SVVGRD
Sbjct: 412  NSKDLKKTDGKKSEKVK-VEKLEDANDAGGRNSDKCTLILTEGDSAKALAMAGISVVGRD 470

Query: 3366 HYGVFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTDQ 3187
            HYGVFPLRGKLLNVR+AS KQ+++N EI+ IKKILGLQ GK+Y+S+KSLRYGHLMIMTDQ
Sbjct: 471  HYGVFPLRGKLLNVREASHKQVSENKEIEAIKKILGLQTGKEYESVKSLRYGHLMIMTDQ 530

Query: 3186 DHDGSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKRSFYTMPEYESWKE 3007
            DHDGSHIKGLLINFIH+FWPSLL++PSFL+EFITPIVKATHK+G+  SFYTMPEYESW++
Sbjct: 531  DHDGSHIKGLLINFIHTFWPSLLKVPSFLIEFITPIVKATHKSGKILSFYTMPEYESWRK 590

Query: 3006 SLGDKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKKKIE 2827
            SLG  +  WSIKYYKGLGTST KEGKEYF+DL+KH+KDF+WAD+ DGE+IELAFSKKKIE
Sbjct: 591  SLGANSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFIWADNQDGESIELAFSKKKIE 650

Query: 2826 ARKNWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRKILF 2647
            ARKNWLRQFEPGT+LDQ++K I Y +FVNKELILFS+ADLQRSIPSM+DGLKPGQRKILF
Sbjct: 651  ARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIPSMLDGLKPGQRKILF 710

Query: 2646 CAFKRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNGQFG 2467
            CAFKRNFV EAKV QF+GYVSEHSAYHHGEQSL+STIIGMAQ YVGSNN+N+L+PNGQFG
Sbjct: 711  CAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYVGSNNVNLLQPNGQFG 770

Query: 2466 TRNQGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVVLVN 2287
            TRN GGKDHAS+RYI+T+LS I RFLFPK+DD +LDY NEDGQ IEPTWYVPI+P+VL+N
Sbjct: 771  TRNMGGKDHASSRYIYTRLSPIARFLFPKEDDTILDYLNEDGQYIEPTWYVPIVPMVLIN 830

Query: 2286 GSEGIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAGATY 2107
            GSEGIGTGWSS+VPNYNPRD++ANVR +L DEPMEPMDPWYKGF+GTIEKTATKEAGATY
Sbjct: 831  GSEGIGTGWSSYVPNYNPRDLVANVRRLLNDEPMEPMDPWYKGFKGTIEKTATKEAGATY 890

Query: 2106 TVTGIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY--------PFIEDVREYHTTDSVN 1951
            TVTGIIEEV++TTLR++ELPVR+WT+DYK FLES+         PFI++VR Y   +SV 
Sbjct: 891  TVTGIIEEVNETTLRISELPVRRWTEDYKQFLESMTVSNDKAKDPFIKEVRAYGDENSVC 950

Query: 1950 FEIDLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSIRF 1771
            FE+ +SEEN+ +A+QEGLLKKFKL TTISTSNMHLFDS G IKKYD PE ILE+F+ +R 
Sbjct: 951  FEVIMSEENLILAQQEGLLKKFKLATTISTSNMHLFDSNGKIKKYDNPEDILEEFYHVRL 1010

Query: 1770 EFYEKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPFPK 1591
            E+YEKRKKAL++ LE ELL +ENKV+FI+ VV+G+I+V+NR+RADL+LELKEKGFTPFPK
Sbjct: 1011 EYYEKRKKALLEILELELLRIENKVKFILGVVKGEIIVNNRKRADLLLELKEKGFTPFPK 1070

Query: 1590 KAKTTEISVAGSTDVPEETEENSDMASQGVRASDYDYLLSMSIGSLTIEKVQELCNNRDK 1411
            K K  E  VA ++D  E++EE     ++GVRA DYDYLLSM IG+LT+EKVQELC  RDK
Sbjct: 1071 K-KAVEAVVADTSDDAEDSEEE---LNRGVRAGDYDYLLSMPIGTLTLEKVQELCAERDK 1126

Query: 1410 LIQEVEEMRKATINSLWTKDLDALERELDEQDRRDALTEEEAMEIKAKTRRAS--KPATK 1237
            L  EVE+MR AT   LW KDLD LE++LDEQD+ D   EE   +IK K   A+  K    
Sbjct: 1127 LNGEVEDMRNATPKLLWLKDLDVLEKQLDEQDKIDIQAEEAREKIKKKVMNAAGLKAPKP 1186

Query: 1236 NPRKNNKKISKTESAAEPMEIST--NSEIETVSANIGPFPPSDNARVAVQKKAPRKGKSV 1063
             PRKN KK S  ES AEPM+  +  NS    VS +         AR    KKAP K K +
Sbjct: 1187 KPRKNVKKASVVESTAEPMDXVSCFNSGNRLVSNSNVTEVVKPKAR-GGSKKAPAKAKPI 1245

Query: 1062 AAL-KDEEDDDEILALNERIAAYNLDSSPDH-AEAPEAEVSEVQIKNKGPTRKAAATKKP 889
            A   ++EE+DDE+LAL +R+AAYNL+SSPDH AEA E E  + Q   K PTRKAAA KK 
Sbjct: 1246 AVEDEEEEEDDEVLALKDRLAAYNLNSSPDHSAEAMETEAPKAQ--KKAPTRKAAAKKKT 1303

Query: 888  LSTVTXXXXXXXXXXXXXXEVIPAE----EKKKAGRKPATAKTT-----KPPVGAKKRGP 736
            L ++               +    E     KKK GRKPATAK       +PP   KKRGP
Sbjct: 1304 LPSIADVSEGEDEIEISDDDESEPEVAVGGKKKGGRKPATAKAAPAAAKQPP---KKRGP 1360

Query: 735  AAKQSQILGQKLITEVLQGAAD----SPDKKVRKMRISPFNKKSGSVLGRXXXXXXXXXX 568
            A KQ+  +GQKLIT +L+ A +    SP+KKVRKMR SPFNKKSG+VLG+          
Sbjct: 1361 ANKQAVGIGQKLITSILKPAENTDNSSPEKKVRKMRASPFNKKSGAVLGKNKGSTSQENE 1420

Query: 567  XXXXXXXXES------NQVVVPRARPQRANSRKATYVLSDDDSED 451
                     S        VV P+AR  R   +K TYV+SD D+ED
Sbjct: 1421 DASPVSSLGSLEDEVNEAVVAPKARVTR--GKKTTYVISDSDNED 1463


>ref|XP_010324649.1| PREDICTED: DNA topoisomerase 2 isoform X1 [Solanum lycopersicum]
          Length = 1478

 Score = 1953 bits (5059), Expect = 0.0
 Identities = 1002/1479 (67%), Positives = 1177/1479 (79%), Gaps = 36/1479 (2%)
 Frame = -1

Query: 4779 MAPKKAPLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHN 4600
            MA KK PL SS+NANI             KTIEQTYQKKTQLEHILLRPDTYIGS+EKH 
Sbjct: 1    MATKKLPLQSSSNANIT--------NANGKTIEQTYQKKTQLEHILLRPDTYIGSVEKHT 52

Query: 4599 QTLWVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVY 4420
            Q LWV+E+ +MV +P+TYVPGLYKIFDEILVNAADNKQRDPKM++L+V ID   N +SVY
Sbjct: 53   QALWVWEDDRMVHRPVTYVPGLYKIFDEILVNAADNKQRDPKMDALEVVIDPRQNLVSVY 112

Query: 4419 NNGDGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVI 4240
            NNGDG+PVEIHQEEGVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVI
Sbjct: 113  NNGDGIPVEIHQEEGVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVI 172

Query: 4239 ETADGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVAL 4060
            ETADG+RQ+KYKQVF+ NMG K +P+I+KCK SENWT+V+FKPDL+KFNM  LE DVVAL
Sbjct: 173  ETADGKRQKKYKQVFSNNMGKKGEPIITKCKASENWTRVSFKPDLAKFNMEELEADVVAL 232

Query: 4059 MKKRVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKS--AFRIEEKVD------RWE 3904
            M+KRVID+ GCLGK VKV+LN + I V+SF +YC L+L S  A R   KV+      RWE
Sbjct: 233  MRKRVIDLGGCLGKTVKVKLNEQRIPVKSFEEYCKLFLDSHDAKREFLKVNDANGVLRWE 292

Query: 3903 VCVSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYVNKKRKNANLKPHSVRNH 3724
            +CVSLS+GQFQQVSFVNSI+TIKGGTHVDYV NQIA H+   VN+K KNAN+K H+V+NH
Sbjct: 293  ICVSLSEGQFQQVSFVNSIATIKGGTHVDYVANQIANHIMGVVNRKNKNANIKAHAVKNH 352

Query: 3723 LWVFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVA-NSEIVNNILEWAEFK 3547
            LW+FVN LIDNPAFDSQTKETLTLRQ SFGS+C+L   FL KV  N  IV+++L WA+FK
Sbjct: 353  LWMFVNALIDNPAFDSQTKETLTLRQSSFGSKCELQPDFLKKVEKNIGIVDSLLSWADFK 412

Query: 3546 EKKDLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGRD 3367
              KDLKKTDG KS ++  + KL DAN+AGGRNS+KCTLILTEGDSA  LA+AG+SVVGRD
Sbjct: 413  LSKDLKKTDGKKSDKVK-VEKLEDANDAGGRNSDKCTLILTEGDSAKALAMAGISVVGRD 471

Query: 3366 HYGVFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTDQ 3187
            HYGVFPLRGKLLNVR+AS KQ+++N EI++IKKILGLQ GK+YDS+KSLRYGHLMIMTDQ
Sbjct: 472  HYGVFPLRGKLLNVREASHKQVSENKEIESIKKILGLQTGKEYDSVKSLRYGHLMIMTDQ 531

Query: 3186 DHDGSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKRSFYTMPEYESWKE 3007
            DHDGSHIKGLLINFIH+FWPSLL++PSFLVEFITPIVKATHK+G   +FYTMPEYE+W+ 
Sbjct: 532  DHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSGRILAFYTMPEYEAWRR 591

Query: 3006 SLGDKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKKKIE 2827
            SLG  +  WSIKYYKGLGTST KEGKEYF+DL+KH+KDFVWAD+ DGE+IELAFSKKKIE
Sbjct: 592  SLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFVWADNQDGESIELAFSKKKIE 651

Query: 2826 ARKNWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRKILF 2647
            ARKNWLRQFEPGT+LDQ++K I Y +FVNKELILFS+ADLQRSIPSM+DGLKPGQRKILF
Sbjct: 652  ARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIPSMLDGLKPGQRKILF 711

Query: 2646 CAFKRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNGQFG 2467
            CAFKRNFV EAKV QF+GYVSEHSAYHHGEQSL+STIIGMAQ YVGSNN+N+L+PNGQFG
Sbjct: 712  CAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYVGSNNVNLLQPNGQFG 771

Query: 2466 TRNQGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVVLVN 2287
            TRN GGKDHAS+RYI+T+LS I RFLFPKDDD +LDY NEDGQ+IEPTWYVP+IP VLVN
Sbjct: 772  TRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTILDYLNEDGQSIEPTWYVPVIPTVLVN 831

Query: 2286 GSEGIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAGATY 2107
            GSEGIGTGWSS+VPNYNPRD++ANVR +L DE MEPMDPWYKGF+G IEKTATKE GATY
Sbjct: 832  GSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGFKGKIEKTATKETGATY 891

Query: 2106 TVTGIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY--------PFIEDVREYHTTDSVN 1951
            TVTGIIEEVS+TTLR++ELPVR+WT+DYK FLES+          FI++VR Y   +SV 
Sbjct: 892  TVTGIIEEVSETTLRISELPVRRWTEDYKQFLESMTVSTDKAKDSFIKEVRAYGDENSVC 951

Query: 1950 FEIDLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSIRF 1771
            FE+ +SE+N+ +A+QEGLLKKFKLTTTISTSNMHLFDSKG IKKYD PE+ILE+F+ +R 
Sbjct: 952  FEVIMSEDNLLLAQQEGLLKKFKLTTTISTSNMHLFDSKGKIKKYDAPEEILEEFYHVRL 1011

Query: 1770 EFYEKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPFPK 1591
            E+YEKRKKAL++ LE ELL +ENKV+FI+ VV+G+I+V+NR+RA+L+LELK KGFTPFPK
Sbjct: 1012 EYYEKRKKALLEILELELLRIENKVKFILGVVKGEIIVNNRKRAELLLELKNKGFTPFPK 1071

Query: 1590 KAKTTEISVAGSTDVPEETEENSDMASQGVRASDYDYLLSMSIGSLTIEKVQELCNNRDK 1411
            K K  E  VA STD  +++EE+ + +S+GVRASDYDYLLSM+IG+LT+EKVQELC +RDK
Sbjct: 1072 K-KPVEAVVADSTDDADDSEESPEESSRGVRASDYDYLLSMAIGTLTLEKVQELCADRDK 1130

Query: 1410 LIQEVEEMRKATINSLWTKDLDALERELDEQDRRDALTEEEAMEIKAKTRRAS-KPATK- 1237
            L  EVE+MR AT   LW KDLD L+++LDEQD+ D  TEE   ++K K   A+ K A K 
Sbjct: 1131 LNAEVEDMRNATPKHLWMKDLDVLDKQLDEQDKIDIQTEEAREKLKKKVMNAAGKAAPKP 1190

Query: 1236 NPRKNNKKISKTESAAEPMEISTNSEIETVSANIGPF-PPSDNARVAVQKKAPRKGKSVA 1060
             PRK NKK    ES AE M++S  S  ET  AN+     P    R A Q K         
Sbjct: 1191 KPRKTNKK---AESTAESMDVSFGSTAET--ANVSEVVKPKGRGRPAKQAKP-------I 1238

Query: 1059 ALKDEEDDDEILALNERIAAYNLDSSPDHAEAPEAEVSEVQIKNKGPTRKAAATKKPLST 880
             ++DEE++DE+LAL +R+AAYNL+SSPD +E  E EV + Q   K P ++AAA KK L +
Sbjct: 1239 VVEDEEEEDEVLALKDRLAAYNLNSSPDRSEVTETEVPKAQ--TKAPAKRAAAQKKALPS 1296

Query: 879  VTXXXXXXXXXXXXXXEVIPAEE---KKKAGRKPATAKTTKPPVGAKKRGPAAKQSQILG 709
                            E  PA     KKK GRKPA AK    P    K+ PA  QSQ +G
Sbjct: 1297 TPDVSDGEDAIEIDDDEFEPAAAVGGKKKGGRKPAAAKAAAAPKPPGKKAPANNQSQSVG 1356

Query: 708  QKLITEVLQGAAD---SPDKKVRKMRISPFNKKSGSVLGRXXXXXXXXXXXXXXXXXXE- 541
            Q+LIT+VL+ A D   SPD+KVRKMR SPFNKKSG+V+G+                    
Sbjct: 1357 QRLITQVLKPAEDAGVSPDRKVRKMRASPFNKKSGAVMGKNTSSSSTSSHESEEVSPLIP 1416

Query: 540  ---------SNQVVVPRARPQRANSRKATYVLSDDDSED 451
                     S  VV P+ARPQRA  +  TYV+SD D+E+
Sbjct: 1417 SLGSLDEEVSEVVVAPKARPQRATKKTTTYVISDSDTEE 1455


>ref|XP_004229644.1| PREDICTED: DNA topoisomerase 2 isoform X2 [Solanum lycopersicum]
          Length = 1477

 Score = 1952 bits (5058), Expect = 0.0
 Identities = 1002/1479 (67%), Positives = 1178/1479 (79%), Gaps = 36/1479 (2%)
 Frame = -1

Query: 4779 MAPKKAPLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHN 4600
            MA KK PL SS+NANI             KTIEQTYQKKTQLEHILLRPDTYIGS+EKH 
Sbjct: 1    MATKKLPLQSSSNANIT--------NANGKTIEQTYQKKTQLEHILLRPDTYIGSVEKHT 52

Query: 4599 QTLWVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVY 4420
            Q LWV+E+ +MV +P+TYVPGLYKIFDEILVNAADNKQRDPKM++L+V ID   N +SVY
Sbjct: 53   QALWVWEDDRMVHRPVTYVPGLYKIFDEILVNAADNKQRDPKMDALEVVIDPRQNLVSVY 112

Query: 4419 NNGDGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVI 4240
            NNGDG+PVEIHQEEGVYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEFVI
Sbjct: 113  NNGDGIPVEIHQEEGVYVPELIFGHLLTSSNYDDAEKKTTGGRNGYGAKLTNIFSTEFVI 172

Query: 4239 ETADGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVAL 4060
            ETADG+RQ+KYKQVF+ NMG K +P+I+KCK SENWT+V+FKPDL+KFNM  LE DVVAL
Sbjct: 173  ETADGKRQKKYKQVFSNNMGKKGEPIITKCKASENWTRVSFKPDLAKFNMEELEADVVAL 232

Query: 4059 MKKRVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKS--AFRIEEKVD------RWE 3904
            M+KRVID+ GCLGK VKV+LN + I V+SF +YC L+L S  A R   KV+      RWE
Sbjct: 233  MRKRVIDLGGCLGKTVKVKLNEQRIPVKSFEEYCKLFLDSHDAKREFLKVNDANGVLRWE 292

Query: 3903 VCVSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYVNKKRKNANLKPHSVRNH 3724
            +CVSLS+GQFQQVSFVNSI+TIKGGTHVDYV NQIA H+   VN+K KNAN+K H+V+NH
Sbjct: 293  ICVSLSEGQFQQVSFVNSIATIKGGTHVDYVANQIANHIMGVVNRKNKNANIKAHAVKNH 352

Query: 3723 LWVFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVA-NSEIVNNILEWAEFK 3547
            LW+FVN LIDNPAFDSQTKETLTLRQ SFGS+C+L   FL KV  N  IV+++L WA+FK
Sbjct: 353  LWMFVNALIDNPAFDSQTKETLTLRQSSFGSKCELQPDFLKKVEKNIGIVDSLLSWADFK 412

Query: 3546 EKKDLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGRD 3367
              KDLKKTDG KS ++  + KL DAN+AGGRNS+KCTLILTEGDSA  LA+AG+SVVGRD
Sbjct: 413  LSKDLKKTDGKKSDKVK-VEKLEDANDAGGRNSDKCTLILTEGDSAKALAMAGISVVGRD 471

Query: 3366 HYGVFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTDQ 3187
            HYGVFPLRGKLLNVR+AS KQ+++N EI++IKKILGLQ GK+YDS+KSLRYGHLMIMTDQ
Sbjct: 472  HYGVFPLRGKLLNVREASHKQVSENKEIESIKKILGLQTGKEYDSVKSLRYGHLMIMTDQ 531

Query: 3186 DHDGSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKRSFYTMPEYESWKE 3007
            DHDGSHIKGLLINFIH+FWPSLL++PSFLVEFITPIVKATHK+G   +FYTMPEYE+W+ 
Sbjct: 532  DHDGSHIKGLLINFIHTFWPSLLKVPSFLVEFITPIVKATHKSGRILAFYTMPEYEAWRR 591

Query: 3006 SLGDKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKKKIE 2827
            SLG  +  WSIKYYKGLGTST KEGKEYF+DL+KH+KDFVWAD+ DGE+IELAFSKKKIE
Sbjct: 592  SLGATSSGWSIKYYKGLGTSTSKEGKEYFQDLQKHRKDFVWADNQDGESIELAFSKKKIE 651

Query: 2826 ARKNWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRKILF 2647
            ARKNWLRQFEPGT+LDQ++K I Y +FVNKELILFS+ADLQRSIPSM+DGLKPGQRKILF
Sbjct: 652  ARKNWLRQFEPGTHLDQKEKYISYTEFVNKELILFSMADLQRSIPSMLDGLKPGQRKILF 711

Query: 2646 CAFKRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNGQFG 2467
            CAFKRNFV EAKV QF+GYVSEHSAYHHGEQSL+STIIGMAQ YVGSNN+N+L+PNGQFG
Sbjct: 712  CAFKRNFVKEAKVSQFSGYVSEHSAYHHGEQSLSSTIIGMAQDYVGSNNVNLLQPNGQFG 771

Query: 2466 TRNQGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVVLVN 2287
            TRN GGKDHAS+RYI+T+LS I RFLFPKDDD +LDY NEDGQ+IEPTWYVP+IP VLVN
Sbjct: 772  TRNMGGKDHASSRYIYTRLSPIARFLFPKDDDTILDYLNEDGQSIEPTWYVPVIPTVLVN 831

Query: 2286 GSEGIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAGATY 2107
            GSEGIGTGWSS+VPNYNPRD++ANVR +L DE MEPMDPWYKGF+G IEKTATKE GATY
Sbjct: 832  GSEGIGTGWSSYVPNYNPRDLVANVRRLLNDELMEPMDPWYKGFKGKIEKTATKETGATY 891

Query: 2106 TVTGIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY--------PFIEDVREYHTTDSVN 1951
            TVTGIIEEVS+TTLR++ELPVR+WT+DYK FLES+          FI++VR Y   +SV 
Sbjct: 892  TVTGIIEEVSETTLRISELPVRRWTEDYKQFLESMTVSTDKAKDSFIKEVRAYGDENSVC 951

Query: 1950 FEIDLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSIRF 1771
            FE+ +SE+N+ +A+QEGLLKKFKLTTTISTSNMHLFDSKG IKKYD PE+ILE+F+ +R 
Sbjct: 952  FEVIMSEDNLLLAQQEGLLKKFKLTTTISTSNMHLFDSKGKIKKYDAPEEILEEFYHVRL 1011

Query: 1770 EFYEKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPFPK 1591
            E+YEKRKKAL++ LE ELL +ENKV+FI+ VV+G+I+V+NR+RA+L+LELK KGFTPFPK
Sbjct: 1012 EYYEKRKKALLEILELELLRIENKVKFILGVVKGEIIVNNRKRAELLLELKNKGFTPFPK 1071

Query: 1590 KAKTTEISVAGSTDVPEETEENSDMASQGVRASDYDYLLSMSIGSLTIEKVQELCNNRDK 1411
            K K  E  VA STD  +++EE+ + +S+GVRASDYDYLLSM+IG+LT+EKVQELC +RDK
Sbjct: 1072 K-KPVEAVVADSTDDADDSEESPEESSRGVRASDYDYLLSMAIGTLTLEKVQELCADRDK 1130

Query: 1410 LIQEVEEMRKATINSLWTKDLDALERELDEQDRRDALTEEEAMEIKAKTRRAS-KPATK- 1237
            L  EVE+MR AT   LW KDLD L+++LDEQD+ D  TEE   ++K K   A+ K A K 
Sbjct: 1131 LNAEVEDMRNATPKHLWMKDLDVLDKQLDEQDKIDIQTEEAREKLKKKVMNAAGKAAPKP 1190

Query: 1236 NPRKNNKKISKTESAAEPMEISTNSEIETVSANIGPF-PPSDNARVAVQKKAPRKGKSVA 1060
             PRK NKK    ES AE M++S  S  ET  AN+     P    R       P K K + 
Sbjct: 1191 KPRKTNKK---AESTAESMDVSFGSTAET--ANVSEVVKPKGRGR-------PAKAKPIV 1238

Query: 1059 ALKDEEDDDEILALNERIAAYNLDSSPDHAEAPEAEVSEVQIKNKGPTRKAAATKKPLST 880
             ++DEE++DE+LAL +R+AAYNL+SSPD +E  E EV + Q   K P ++AAA KK L +
Sbjct: 1239 -VEDEEEEDEVLALKDRLAAYNLNSSPDRSEVTETEVPKAQ--TKAPAKRAAAQKKALPS 1295

Query: 879  VTXXXXXXXXXXXXXXEVIPAEE---KKKAGRKPATAKTTKPPVGAKKRGPAAKQSQILG 709
                            E  PA     KKK GRKPA AK    P    K+ PA  QSQ +G
Sbjct: 1296 TPDVSDGEDAIEIDDDEFEPAAAVGGKKKGGRKPAAAKAAAAPKPPGKKAPANNQSQSVG 1355

Query: 708  QKLITEVLQGAAD---SPDKKVRKMRISPFNKKSGSVLGRXXXXXXXXXXXXXXXXXXE- 541
            Q+LIT+VL+ A D   SPD+KVRKMR SPFNKKSG+V+G+                    
Sbjct: 1356 QRLITQVLKPAEDAGVSPDRKVRKMRASPFNKKSGAVMGKNTSSSSTSSHESEEVSPLIP 1415

Query: 540  ---------SNQVVVPRARPQRANSRKATYVLSDDDSED 451
                     S  VV P+ARPQRA  +  TYV+SD D+E+
Sbjct: 1416 SLGSLDEEVSEVVVAPKARPQRATKKTTTYVISDSDTEE 1454


>ref|XP_012455306.1| PREDICTED: DNA topoisomerase 2 isoform X1 [Gossypium raimondii]
            gi|763806992|gb|KJB73930.1| hypothetical protein
            B456_011G261600 [Gossypium raimondii]
          Length = 1462

 Score = 1949 bits (5048), Expect = 0.0
 Identities = 993/1469 (67%), Positives = 1171/1469 (79%), Gaps = 26/1469 (1%)
 Frame = -1

Query: 4779 MAPKKAPLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHN 4600
            +A  K PL SSNN N              KTIE+TYQKKTQLEHILLRPDTYIGSIE+H 
Sbjct: 2    VADSKLPLQSSNNVNTKAS----------KTIEETYQKKTQLEHILLRPDTYIGSIEQHT 51

Query: 4599 QTLWVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVY 4420
            Q LWVYE  +MV + I YVPGLYKIFDEILVNAADNKQRDP M+S+KV IDAE N ISVY
Sbjct: 52   QRLWVYENDEMVHRDIKYVPGLYKIFDEILVNAADNKQRDPSMDSIKVVIDAEQNLISVY 111

Query: 4419 NNGDGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVI 4240
            NNGDGVPVEIHQEE VYVPELIFGHLLTSSNYDD+ KKTTGGRNGYGAKLTNIFSTEFVI
Sbjct: 112  NNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDNVKKTTGGRNGYGAKLTNIFSTEFVI 171

Query: 4239 ETADGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVAL 4060
            ETADG+RQ+KYKQVF  NMG+K++PVI+KCKE ENWTKVTFKPDL+KFNMTHLEDDVVAL
Sbjct: 172  ETADGKRQKKYKQVFKNNMGSKTEPVITKCKEGENWTKVTFKPDLAKFNMTHLEDDVVAL 231

Query: 4059 MKKRVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAF--------RIEEKVD-RW 3907
            M+KRV D+AGCLGK VKVELNG+ I V+SF DY NLYL +A         RI EKV+ RW
Sbjct: 232  MRKRVFDLAGCLGKTVKVELNGKRIAVKSFLDYVNLYLSAASKNKSEPLPRISEKVNARW 291

Query: 3906 EVCVSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYVNKKRKNANLKPHSVRN 3727
            EVCVSLS+GQFQQVSFVNSI+TIKGGTHVDYVTNQI+ ++   VNKK KNAN+K H+V+N
Sbjct: 292  EVCVSLSEGQFQQVSFVNSIATIKGGTHVDYVTNQISNYVMNAVNKKNKNANVKAHNVKN 351

Query: 3726 HLWVFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVANSEIVNNILEWAEFK 3547
            HLWVFVN LIDNPAFDSQTKETLTLRQ SFGS+C+L + FL KVA S +V+N+L+WAEFK
Sbjct: 352  HLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELPEDFLKKVAKSGVVDNLLQWAEFK 411

Query: 3546 EKKDLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGRD 3367
              KDLKKTDGTKS  I G+ KL DAN AGGRNS+KCTLILTEGDSA +LA+AGLSVVGR+
Sbjct: 412  HSKDLKKTDGTKSGSIRGIPKLDDANEAGGRNSDKCTLILTEGDSAKSLAVAGLSVVGRN 471

Query: 3366 HYGVFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTDQ 3187
            HYGV+PLRGKLLNVR+AS KQ+ +NAEIQN+K+ILGLQ  K+Y  +KSLRYGHLMIMTDQ
Sbjct: 472  HYGVYPLRGKLLNVREASHKQLMENAEIQNLKRILGLQQNKEYTDVKSLRYGHLMIMTDQ 531

Query: 3186 DHDGSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKAT---HKNGEKRSFYTMPEYES 3016
            DHDGSHIKGLLINFIHSFWPSLL++ SF+VEFITPIVKAT   +K  E+  FYTMPEY++
Sbjct: 532  DHDGSHIKGLLINFIHSFWPSLLKVKSFMVEFITPIVKATRKVNKQEEELCFYTMPEYQA 591

Query: 3015 WKESLGDKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKK 2836
            WKESLG  A+SW IKYYKGLGTST  EGK+YFKD++KH K+FVW  D DG+AIELAFSKK
Sbjct: 592  WKESLGTNAKSWRIKYYKGLGTSTGPEGKKYFKDIDKHMKEFVWEGDMDGDAIELAFSKK 651

Query: 2835 KIEARKNWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRK 2656
            KIEARKNWLRQFEPGT+LD  +KLI Y DF+NKELILFS+ADLQRSIPSMVDGLKPGQRK
Sbjct: 652  KIEARKNWLRQFEPGTHLDHNEKLINYSDFINKELILFSMADLQRSIPSMVDGLKPGQRK 711

Query: 2655 ILFCAFKRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNG 2476
            ILFCAFKRNFVHEAKV QF+GYVSEHSAYHHGEQSL STI+GMAQ +VGSNNIN+L+P G
Sbjct: 712  ILFCAFKRNFVHEAKVSQFSGYVSEHSAYHHGEQSLCSTIVGMAQDFVGSNNINLLRPGG 771

Query: 2475 QFGTRNQGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVV 2296
            QFGTRNQGGKD ASARYIFT L+ ITR+LF KDDD LL+Y NEDGQ+IEP+WYVP+IP+V
Sbjct: 772  QFGTRNQGGKDAASARYIFTNLTTITRYLFRKDDDGLLNYLNEDGQSIEPSWYVPVIPMV 831

Query: 2295 LVNGSEGIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAG 2116
            LVNGSEGIGTGWSS++PNYNPRDI+ANVR +L  EPMEPM PWY+GF+GTIEKTA+KE+G
Sbjct: 832  LVNGSEGIGTGWSSYIPNYNPRDIVANVRRLLNGEPMEPMHPWYRGFKGTIEKTASKESG 891

Query: 2115 ATYTVTGIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY----PFIEDVREYHTTDSVNF 1948
             TYT++GI+EEV +TTL++TELP+R+WTQDYK+FLES+      FI++ ++Y    +V+F
Sbjct: 892  VTYTISGIVEEVDETTLKITELPIRRWTQDYKEFLESVITANDSFIKEFKQYSDDRTVHF 951

Query: 1947 EIDLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSIRFE 1768
            E+ ++EENM +AKQEGL+KKFKLTTT+STSNMHLFDS+G+IKKYDTPE+IL++F+ +R E
Sbjct: 952  EVFMTEENMMLAKQEGLMKKFKLTTTVSTSNMHLFDSRGMIKKYDTPEEILDEFYHLRLE 1011

Query: 1767 FYEKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPFPKK 1588
            FYEKR+K ++D LE ELL ++NKVRFI+DVV+G I+V+NR+RADL LEL+EKGFTPFPKK
Sbjct: 1012 FYEKRRKHMLDTLELELLKMDNKVRFILDVVKGNIIVNNRKRADLFLELQEKGFTPFPKK 1071

Query: 1587 AKTTEISVAGSTDVPEETEENSDMASQGVRASDYDYLLSMSIGSLTIEKVQELCNNRDKL 1408
             K  E++VAG  D   E E    ++ +  RASDYDYLLSM+IG+LT+EKVQELC++RDKL
Sbjct: 1072 TKAVEVAVAGDIDHEGEPE----LSPEATRASDYDYLLSMAIGTLTLEKVQELCSDRDKL 1127

Query: 1407 IQEVEEMRKATINSLWTKDLDALERELDEQDRRDALTEEEAMEIKAK----TRRASKP-A 1243
              EVEE+RK T  SLW KDL+ LE++LDEQD+ D   EEE  + +AK     ++A +P A
Sbjct: 1128 EHEVEELRKHTPKSLWLKDLEELEKQLDEQDQADLEAEEENSKNRAKGGVAGKKARRPVA 1187

Query: 1242 TKNPRKNNKKISKTESAAEPMEISTNSEIETVSANIGPFPPSDNARVAVQKKAPRKGKSV 1063
            +KNP+K NKK     S A  +  +T  E E   A + P       R   +KK  ++  S 
Sbjct: 1188 SKNPKKVNKKDDPQVSEASEISSTTAMEAEKAPAVVKP-----KGRAGAKKKTKKQDDSD 1242

Query: 1062 AALKDEEDDDEILALNERIAAYNLDSSPDHAEAPEAEVSEVQIKNKGPTRKAAATKK-PL 886
                D+ DD +I  L ER+A +N+DSSPDH+   E E+ +     KGP ++AAATKK P+
Sbjct: 1243 DD-DDDNDDFDIPDLRERLAKHNIDSSPDHSADMETEMFQEPAGKKGPAKRAAATKKNPV 1301

Query: 885  STVTXXXXXXXXXXXXXXEVIPA-EEKKKAGRKPATAKTTKPPVGAKKRGPAA-KQSQIL 712
             +++               V PA    KK GRKPA  K  KPP  AKKRGPAA KQ ++L
Sbjct: 1302 ISLSESIGEINISDGELEVVEPAPAATKKGGRKPAAPKAGKPPAAAKKRGPAAGKQQKLL 1361

Query: 711  GQKL--ITEVLQGAADSPDKKVRKMRISPFNKKSGSVLGRXXXXXXXXXXXXXXXXXXES 538
             Q L   TE  +G+  SP+KKVRKMR SPFNKKSGSVLG+                  E 
Sbjct: 1362 TQMLKPATEA-EGSGISPEKKVRKMRASPFNKKSGSVLGKTSSSSLSSMPEIESDDDEEV 1420

Query: 537  NQVVVPRARPQRANSRKATYVLSDDDSED 451
              VV PRARPQRAN  K TYV+SD ++E+
Sbjct: 1421 AVVVEPRARPQRANRTKTTYVVSDSETEE 1449


>ref|XP_010023678.1| PREDICTED: DNA topoisomerase 2-like [Eucalyptus grandis]
            gi|629094018|gb|KCW60013.1| hypothetical protein
            EUGRSUZ_H02748 [Eucalyptus grandis]
          Length = 1496

 Score = 1948 bits (5047), Expect = 0.0
 Identities = 996/1485 (67%), Positives = 1168/1485 (78%), Gaps = 49/1485 (3%)
 Frame = -1

Query: 4761 PLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHNQTLWVY 4582
            PL +SN AN              KT+E+TYQKK+QLEHILLRPDTYIGS+EKH Q+LW+Y
Sbjct: 6    PLQTSNIANTAAAAAAPAAGRKGKTVEETYQKKSQLEHILLRPDTYIGSVEKHTQSLWIY 65

Query: 4581 EEK-----------QMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEAN 4435
            +             +MV +PITYVPGLYKIFDEILVNAADNKQRDP+M+SLKVTIDA+ N
Sbjct: 66   DVGGDGGDGGGGGGEMVHRPITYVPGLYKIFDEILVNAADNKQRDPRMDSLKVTIDADRN 125

Query: 4434 CISVYNNGDGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFS 4255
             ISVYNNGDGVPVE+H+EE VYVPELIFGHLLTSSNYDD+ KKTTGGRNGYGAKLTNIFS
Sbjct: 126  LISVYNNGDGVPVEMHREEHVYVPELIFGHLLTSSNYDDNVKKTTGGRNGYGAKLTNIFS 185

Query: 4254 TEFVIETADGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLED 4075
            TEFVIETADG+   KYKQVF+ NMG K  P I  CK SENWTKV+FKPDL+KFNMTHLED
Sbjct: 186  TEFVIETADGKNGLKYKQVFSKNMGVKGAPDIKACKASENWTKVSFKPDLAKFNMTHLED 245

Query: 4074 DVVALMKKRVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAF---------RIEE 3922
            DVVALMKKRVIDMAGCLGK VKVELNG+ + V++F +Y  LYLKSA          RIEE
Sbjct: 246  DVVALMKKRVIDMAGCLGKTVKVELNGKRVPVKTFAEYVGLYLKSASKNRPECPLPRIEE 305

Query: 3921 KV-DRWEVCVSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYVNKKRKNANLK 3745
             V DRWEVCVSLSDGQFQQVSF N+I+TIKGGTHVDYVTNQIA H+   VNKK KNANLK
Sbjct: 306  TVNDRWEVCVSLSDGQFQQVSFANAIATIKGGTHVDYVTNQIANHVMSVVNKKNKNANLK 365

Query: 3744 PHSVRNHLWVFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVANSEIVNNIL 3565
             H+V++HLWVFVN LIDNPAFDSQTKETLTLRQ SFGS+C+LSDKFL KV  S IV ++L
Sbjct: 366  AHNVKSHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSDKFLQKVVKSGIVESLL 425

Query: 3564 EWAEFKEKKDLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGL 3385
             WA FK  KDLKKTDG+K + + G+ KL DAN+AGGRNS+KCTLILTEGDSA  LA+AGL
Sbjct: 426  SWANFKLSKDLKKTDGSKRENLRGIPKLEDANDAGGRNSDKCTLILTEGDSAKALAMAGL 485

Query: 3384 SVVGRDHYGVFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHL 3205
            SVVGRD YGVFPLRGKLLNVR+AS  QI +N EIQ IK+ILGLQ  K YDS+KSLRYGHL
Sbjct: 486  SVVGRDRYGVFPLRGKLLNVREASHSQIMENKEIQYIKQILGLQQNKDYDSVKSLRYGHL 545

Query: 3204 MIMTDQDHDGSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKRSFYTMPE 3025
            MIMTDQDHDGSHIKGLLINF+HSFWPSLL++PSFLVEFITPIVKATHKNG + SFYTMPE
Sbjct: 546  MIMTDQDHDGSHIKGLLINFVHSFWPSLLKVPSFLVEFITPIVKATHKNGRELSFYTMPE 605

Query: 3024 YESWKESLGDKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAF 2845
            YESWKESLG     WSIKYYKGLGTST KEGK+YF++L+ HKKDFVW DD DG+AIELAF
Sbjct: 606  YESWKESLGGSGSGWSIKYYKGLGTSTSKEGKQYFQNLDMHKKDFVWVDDQDGDAIELAF 665

Query: 2844 SKKKIEARKNWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPG 2665
            SKKKIEARK WLRQFEPGTYLDQ++KLIKY DFVNKELILFS+ADLQRSIPSMVDGLKPG
Sbjct: 666  SKKKIEARKTWLRQFEPGTYLDQKEKLIKYSDFVNKELILFSMADLQRSIPSMVDGLKPG 725

Query: 2664 QRKILFCAFKRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILK 2485
            QRKILFC+FKRNF+ EAKV QF+GYVSEHSAYHHGEQSLASTIIGMAQ YVGSNNIN+L 
Sbjct: 726  QRKILFCSFKRNFIKEAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQDYVGSNNINLLM 785

Query: 2484 PNGQFGTRNQGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPII 2305
            PNGQFGTRN GGKDHAS RY++T+LS  TRFLFPKDDD LL Y NEDGQ+IEPTWY+PI+
Sbjct: 786  PNGQFGTRNMGGKDHASPRYVYTKLSPTTRFLFPKDDDNLLSYLNEDGQSIEPTWYMPIL 845

Query: 2304 PVVLVNGSEGIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATK 2125
            P+VLVNGSEGIGTGWSS++PNYNPRDIIAN+R +L  E MEPMDPWY+GFRGTIEKTATK
Sbjct: 846  PMVLVNGSEGIGTGWSSYIPNYNPRDIIANLRRLLNGEMMEPMDPWYRGFRGTIEKTATK 905

Query: 2124 EAGATYTVTGIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY---------PFIEDVREY 1972
            EAG TYTV GIIEEV DTTLR+TELP+R+WTQDY++FLESL          PF+++ R+Y
Sbjct: 906  EAGVTYTVCGIIEEVDDTTLRITELPIRRWTQDYREFLESLSTGEKDKAKDPFVKEFRQY 965

Query: 1971 HTTDSVNFEIDLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILE 1792
                +V+FE+ L+EENM IAKQEGLLKKFKLT++ISTSNMHLFD  GVIKKYD+PE+ILE
Sbjct: 966  SDDVTVHFEVMLTEENMMIAKQEGLLKKFKLTSSISTSNMHLFDPNGVIKKYDSPEQILE 1025

Query: 1791 DFFSIRFEFYEKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEK 1612
            +FF +R E YEKRKK L++NLE +L++L+NKVRFI+ VV G+I+VSNR+RADL  EL+ K
Sbjct: 1026 EFFHLRLECYEKRKKILLENLELKLVMLDNKVRFILGVVHGEIIVSNRKRADLFQELQAK 1085

Query: 1611 GFTPFPKKAKTTEISVAGSTDVPEETEENSDMASQGVRASDYDYLLSMSIGSLTIEKVQE 1432
            GFTPF K+ KT E +VAGSTD  EETEENS+  ++GV+ASDY+YLLSM+IG+LT+EKVQE
Sbjct: 1086 GFTPFRKETKTIETAVAGSTDDAEETEENSEPTTKGVKASDYEYLLSMAIGALTLEKVQE 1145

Query: 1431 LCNNRDKLIQEVEEMRKATINSLWTKDLDALERELDEQDRRDALTEEEAMEIKAKTR--- 1261
            LC ++DKL+ EV+ +RKAT  +LW +DL ALE +LDEQ++ DA  EE     KA+++   
Sbjct: 1146 LCADKDKLVDEVDALRKATPENLWLEDLAALEEKLDEQEKMDAQAEETR---KARSKANG 1202

Query: 1260 ---RASKPATKNPRKNNKKISKTESAAEPMEISTNSEIETVSANIGPFPPSDNARVAVQK 1090
               + S+ A K PRKN+ K +  E+ A   E++  S +   + N            A + 
Sbjct: 1203 VGTKVSRQAPKKPRKNDTKANNPEAQA---EVTQGSTVTLEAGNAADVAKPKRGAGARKA 1259

Query: 1089 KAPRKGKSVAALKDEEDDDEILALNERIAAYNLDSSPDHAEAPEAEVSEVQIKNKGPTRK 910
             AP+  KS A++ D+++D E+L L ER+AAYNL+SSPD++ A E +V E+ +K K P+++
Sbjct: 1260 PAPKPSKS-ASVSDDDEDFEMLDLKERLAAYNLESSPDNSSALEDKVPEIPVKEKEPSKR 1318

Query: 909  AAATKKP---LSTVTXXXXXXXXXXXXXXEVIPAEE--KKKAGRKP-ATAKTTKPPVGAK 748
            AA  KKP   LS ++               V    E  KKK GRKP A AK +KPP   K
Sbjct: 1319 AATRKKPSVILSEISEEENSNDSGDDDYETVDSEAEVAKKKGGRKPSAAAKKSKPPAATK 1378

Query: 747  KRGPAAKQSQILGQKLITEVLQGAAD---SPDKKVRKMRISPFNKKSGSVLGRXXXXXXX 577
            K     +Q++   Q+L+TE+L+ A     SP+KKVRKMR SPFNKKS S+LG+       
Sbjct: 1379 KGQANRQQARGTSQRLLTEMLKPAESTGVSPEKKVRKMRASPFNKKSSSLLGKEGKADSS 1438

Query: 576  XXXXXXXXXXXESNQVVV----PRARPQRANSRKATYVLSDDDSE 454
                          + VV    P+ RPQR N ++ TYVLSD +SE
Sbjct: 1439 TSEEMSSNPMSNDGEDVVEVAPPKRRPQRVNRKQTTYVLSDSESE 1483


>dbj|BAE06274.1| topoisomerase II [Scutellaria baicalensis]
          Length = 1469

 Score = 1948 bits (5047), Expect = 0.0
 Identities = 1008/1465 (68%), Positives = 1163/1465 (79%), Gaps = 26/1465 (1%)
 Frame = -1

Query: 4770 KKAPLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHNQTL 4591
            KK PLT+SNNANIPP           KTIEQ YQKKTQLEHILLRPDTYIGSIE+H QTL
Sbjct: 5    KKGPLTTSNNANIPPPDAAGGGSK--KTIEQAYQKKTQLEHILLRPDTYIGSIERHTQTL 62

Query: 4590 WVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVYNNG 4411
            WVYE +QMVQK ITYVPGLYKIFDEILVNAADNKQRDPKMNS+KVTID E+NCISVYNNG
Sbjct: 63   WVYENEQMVQKSITYVPGLYKIFDEILVNAADNKQRDPKMNSVKVTIDVESNCISVYNNG 122

Query: 4410 DGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVIETA 4231
            DGVPVEIHQEEGVYVPELIFGHLLTSSNYDD+EKKTTGGRNGYGAKLTNIFSTEFVIETA
Sbjct: 123  DGVPVEIHQEEGVYVPELIFGHLLTSSNYDDNEKKTTGGRNGYGAKLTNIFSTEFVIETA 182

Query: 4230 DGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVALMKK 4051
            DG+R++KYKQVF+ NMG KS+P+ISK +  ++WTK+TFKPDL+KFNMT LEDD VALMKK
Sbjct: 183  DGKREKKYKQVFSNNMGTKSEPIISKRQAGDDWTKITFKPDLAKFNMTCLEDDTVALMKK 242

Query: 4050 RVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAF--------RIEEKV-DRWEVC 3898
            RVID+AGCLGK VKVELNG+    +SF  YC+LY+KS          R EE+V +RW++ 
Sbjct: 243  RVIDIAGCLGKTVKVELNGQKFHFKSFSSYCDLYMKSTSVSSLDPLPRFEEEVHERWQIF 302

Query: 3897 VSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYV---NKKRKNANLKPHSVRN 3727
            VS S+GQFQQVSFVN I+TIKGGTHVDYVTN+I +HL   +   NKK K  +LKPH+V+N
Sbjct: 303  VSRSEGQFQQVSFVNGIATIKGGTHVDYVTNKITSHLVNVIKNKNKKNKKFDLKPHTVKN 362

Query: 3726 HLWVFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVANSEIVNNILEWAEFK 3547
            HLWVFVN LIDNPAFDSQTKETLTLR  SFGS    S  FL +VA S+I+ NI EWAEFK
Sbjct: 363  HLWVFVNALIDNPAFDSQTKETLTLRAASFGSSWDFSSNFLDRVAKSDIMKNIEEWAEFK 422

Query: 3546 EKKDLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGRD 3367
            +KKDLKKTDG+K +RI GL KL+DAN AGGRNS+KCTLILTEGDSA  LAIAGLSVVGRD
Sbjct: 423  QKKDLKKTDGSKDRRIYGLAKLSDANEAGGRNSDKCTLILTEGDSAKALAIAGLSVVGRD 482

Query: 3366 HYGVFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTDQ 3187
            HYGVFPLRGKLLNVR+AS  Q+  N EIQ+IK+ILGLQHGKQY+S+K LRYGHLMIMTDQ
Sbjct: 483  HYGVFPLRGKLLNVREASHNQLMHNLEIQHIKQILGLQHGKQYESVKPLRYGHLMIMTDQ 542

Query: 3186 DHDGSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKR-SFYTMPEYESWK 3010
            DHDGSHIKGLLINFIHSFWPSLL+IPSFL+ FITPIVKA HK+G+++ SFYTMP+YE+WK
Sbjct: 543  DHDGSHIKGLLINFIHSFWPSLLKIPSFLLGFITPIVKARHKDGKRKLSFYTMPQYEAWK 602

Query: 3009 ESLGDKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKKKI 2830
            E+ G +A++W++KYYKGLGTSTD+E  EYF DL KH+KDFV+ D  D +AIELAFSKKKI
Sbjct: 603  EAQGTEAKNWTVKYYKGLGTSTDQEAMEYFSDLGKHEKDFVYVDGEDDDAIELAFSKKKI 662

Query: 2829 EARKNWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRKIL 2650
            EARK WLRQFEPGT+LD  D  IKYRDFV+KELILFSIAD+QRSIPSMVDGLKPGQRKIL
Sbjct: 663  EARKGWLRQFEPGTFLDDRDSHIKYRDFVHKELILFSIADVQRSIPSMVDGLKPGQRKIL 722

Query: 2649 FCAFKRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNGQF 2470
            FC+FKRNFV EAKV QF+GYVSEHSAYHHGEQSLA TIIGMAQ YVGSNNIN+L P GQF
Sbjct: 723  FCSFKRNFVREAKVAQFSGYVSEHSAYHHGEQSLAGTIIGMAQDYVGSNNINLLLPIGQF 782

Query: 2469 GTRNQGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVVLV 2290
            GTR QGGKDHASARY+FTQLS +TRFLFPK DDILLDY NEDGQ+IEPTWYVPIIP+VLV
Sbjct: 783  GTRGQGGKDHASARYVFTQLSPVTRFLFPKADDILLDYLNEDGQSIEPTWYVPIIPMVLV 842

Query: 2289 NGSEGIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAGAT 2110
            NGSEGIGTGWSS+VPNYNP DIIAN+RH+L DE  EPM PWYKGF G++EKTATKEAGA+
Sbjct: 843  NGSEGIGTGWSSYVPNYNPVDIIANIRHLLNDEATEPMHPWYKGFLGSVEKTATKEAGAS 902

Query: 2109 YTVTGIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY--------PFIEDVREYHTTDSV 1954
            YTV+GIIEEV DTTL + ELP+R+WTQDYK+FLES+         PFIE  R+Y  ++ V
Sbjct: 903  YTVSGIIEEVDDTTLCIKELPIRRWTQDYKEFLESVSAENDKSKDPFIEGCRDYSGSELV 962

Query: 1953 NFEIDLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSIR 1774
            NF + +  E +  AK+EGLLKKFKLTT+IST NMHLFDSKGVIKKYDTPE+ILE+FF IR
Sbjct: 963  NFLVGMKPEKLEAAKREGLLKKFKLTTSISTCNMHLFDSKGVIKKYDTPEQILEEFFYIR 1022

Query: 1773 FEFYEKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPFP 1594
             E YEKRKK L+D LE ++L  +NK RFI  VVEG I+VSNR+R D+  ELKEKGFTPFP
Sbjct: 1023 LELYEKRKKVLLDILEHDMLKCDNKYRFIRCVVEGSIIVSNRKRTDVFRELKEKGFTPFP 1082

Query: 1593 KKAKTTEISVAGSTDVPEETEENSDM-ASQGVRASDYDYLLSMSIGSLTIEKVQELCNNR 1417
            KK    E+++AG+TD  EETEENS++  + GV +SDYDYLLS++IG+LT EK+QEL   R
Sbjct: 1083 KKKNRAEVAIAGATDDGEETEENSEVPIAPGVSSSDYDYLLSLAIGTLTTEKMQELRAER 1142

Query: 1416 DKLIQEVEEMRKATINSLWTKDLDALEREL-DEQDRRDALTEEEAMEIKAKTRRASKPAT 1240
            DKL+QEVEE++++T  SLW KDLDALE +L +EQ   +   E+   +I  KT    +   
Sbjct: 1143 DKLMQEVEELKQSTARSLWNKDLDALEDKLAEEQKIYEETWEKNKRKIHGKT-DTLEIIQ 1201

Query: 1239 KNPRKNNKKISKTESAAEPMEISTNSEIETVSANIGPFPPSDNARVAVQKKAP-RKGKSV 1063
            KNPRK NKK +K ESA E MEIS N+  ET      P       + A +KK P  K  + 
Sbjct: 1202 KNPRK-NKKTTKKESAVE-MEISENTTTETDVKIKKP-----RGKAAAKKKEPAAKVVTA 1254

Query: 1062 AALKDEEDDDEILALNERIAAYNLDSSPDHAEAPEAEVSEVQIKNKGPTRKAAATKKPLS 883
            A ++++EDDD I  L +RIAAYN DSSPDH+E    EV+ VQ KNK P R+ AA KK LS
Sbjct: 1255 APVEEQEDDDGIADLRQRIAAYNFDSSPDHSEDMATEVAPVQTKNKQPARRGAAQKKTLS 1314

Query: 882  TVTXXXXXXXXXXXXXXEVIPAEEKKKAGRKPATAKTTKPPVGAKKRGPAAKQ-SQILGQ 706
              +                 P E+KKK GRKPA AK    P  AKKRGP+AKQ SQ++GQ
Sbjct: 1315 AASETDEDDDAFE-------PEEKKKKGGRKPAAAKA---PAAAKKRGPSAKQSSQLVGQ 1364

Query: 705  KLITEVLQGAA-DSPDKKVRKMRISPFNKKSGSVLGRXXXXXXXXXXXXXXXXXXESNQV 529
            KLITEVL+ AA DSP+KKVR+MR SPFNKKS S+LG+                       
Sbjct: 1365 KLITEVLKPAADDSPEKKVRRMRESPFNKKSSSILGKTINIDDDDEEETSGTSSMNEGAA 1424

Query: 528  VVPRARPQRANSRKATYVLSDDDSE 454
                ARP+RAN  KA YV+SD +S+
Sbjct: 1425 A---ARPKRANRGKAKYVISDSESD 1446


>ref|XP_012455307.1| PREDICTED: DNA topoisomerase 2 isoform X2 [Gossypium raimondii]
            gi|763806991|gb|KJB73929.1| hypothetical protein
            B456_011G261600 [Gossypium raimondii]
          Length = 1461

 Score = 1947 bits (5044), Expect = 0.0
 Identities = 992/1469 (67%), Positives = 1169/1469 (79%), Gaps = 26/1469 (1%)
 Frame = -1

Query: 4779 MAPKKAPLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHN 4600
            +A  K PL SSNN N              KTIE+TYQKKTQLEHILLRPDTYIGSIE+H 
Sbjct: 2    VADSKLPLQSSNNVNTKAS----------KTIEETYQKKTQLEHILLRPDTYIGSIEQHT 51

Query: 4599 QTLWVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVY 4420
            Q LWVYE  +MV + I YVPGLYKIFDEILVNAADNKQRDP M+S+KV IDAE N ISVY
Sbjct: 52   QRLWVYENDEMVHRDIKYVPGLYKIFDEILVNAADNKQRDPSMDSIKVVIDAEQNLISVY 111

Query: 4419 NNGDGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVI 4240
            NNGDGVPVEIHQEE VYVPELIFGHLLTSSNYDD+ KKTTGGRNGYGAKLTNIFSTEFVI
Sbjct: 112  NNGDGVPVEIHQEEKVYVPELIFGHLLTSSNYDDNVKKTTGGRNGYGAKLTNIFSTEFVI 171

Query: 4239 ETADGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVAL 4060
            ETADG+RQ+KYKQVF  NMG+K++PVI+KCKE ENWTKVTFKPDL+KFNMTHLEDDVVAL
Sbjct: 172  ETADGKRQKKYKQVFKNNMGSKTEPVITKCKEGENWTKVTFKPDLAKFNMTHLEDDVVAL 231

Query: 4059 MKKRVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAF--------RIEEKVD-RW 3907
            M+KRV D+AGCLGK VKVELNG+ I V+SF DY NLYL +A         RI EKV+ RW
Sbjct: 232  MRKRVFDLAGCLGKTVKVELNGKRIAVKSFLDYVNLYLSAASKNKSEPLPRISEKVNARW 291

Query: 3906 EVCVSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYVNKKRKNANLKPHSVRN 3727
            EVCVSLS+GQFQQVSFVNSI+TIKGGTHVDYVTNQI+ ++   VNKK KNAN+K H+V+N
Sbjct: 292  EVCVSLSEGQFQQVSFVNSIATIKGGTHVDYVTNQISNYVMNAVNKKNKNANVKAHNVKN 351

Query: 3726 HLWVFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVANSEIVNNILEWAEFK 3547
            HLWVFVN LIDNPAFDSQTKETLTLRQ SFGS+C+L + FL KVA S +V+N+L+WAEFK
Sbjct: 352  HLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELPEDFLKKVAKSGVVDNLLQWAEFK 411

Query: 3546 EKKDLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGRD 3367
              KDLKKTDGTKS  I G+ KL DAN AGGRNS+KCTLILTEGDSA +LA+AGLSVVGR+
Sbjct: 412  HSKDLKKTDGTKSGSIRGIPKLDDANEAGGRNSDKCTLILTEGDSAKSLAVAGLSVVGRN 471

Query: 3366 HYGVFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTDQ 3187
            HYGV+PLRGKLLNVR+AS KQ+ +NAEIQN+K+ILGLQ  K+Y  +KSLRYGHLMIMTDQ
Sbjct: 472  HYGVYPLRGKLLNVREASHKQLMENAEIQNLKRILGLQQNKEYTDVKSLRYGHLMIMTDQ 531

Query: 3186 DHDGSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKAT---HKNGEKRSFYTMPEYES 3016
            DHDGSHIKGLLINFIHSFWPSLL++ SF+VEFITPIVKAT   +K  E+  FYTMPEY++
Sbjct: 532  DHDGSHIKGLLINFIHSFWPSLLKVKSFMVEFITPIVKATRKVNKQEEELCFYTMPEYQA 591

Query: 3015 WKESLGDKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKK 2836
            WKESLG  A+SW IKYYKGLGTST  EGK+YFKD++KH K+FVW  D DG+AIELAFSKK
Sbjct: 592  WKESLGTNAKSWRIKYYKGLGTSTGPEGKKYFKDIDKHMKEFVWEGDMDGDAIELAFSKK 651

Query: 2835 KIEARKNWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRK 2656
            KIEARKNWLRQFEPGT+LD  +KLI Y DF+NKELILFS+ADLQRSIPSMVDGLKPGQRK
Sbjct: 652  KIEARKNWLRQFEPGTHLDHNEKLINYSDFINKELILFSMADLQRSIPSMVDGLKPGQRK 711

Query: 2655 ILFCAFKRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNG 2476
            ILFCAFKRNFVHEAKV QF+GYVSEHSAYHHGEQSL STI+GMAQ +VGSNNIN+L+P G
Sbjct: 712  ILFCAFKRNFVHEAKVSQFSGYVSEHSAYHHGEQSLCSTIVGMAQDFVGSNNINLLRPGG 771

Query: 2475 QFGTRNQGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVV 2296
            QFGTRNQGGKD ASARYIFT L+ ITR+LF KDDD LL+Y NEDGQ+IEP+WYVP+IP+V
Sbjct: 772  QFGTRNQGGKDAASARYIFTNLTTITRYLFRKDDDGLLNYLNEDGQSIEPSWYVPVIPMV 831

Query: 2295 LVNGSEGIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAG 2116
            LVNGSEGIGTGWSS++PNYNPRDI+ANVR +L  EPMEPM PWY+GF+GTIEKTA+KE+G
Sbjct: 832  LVNGSEGIGTGWSSYIPNYNPRDIVANVRRLLNGEPMEPMHPWYRGFKGTIEKTASKESG 891

Query: 2115 ATYTVTGIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY----PFIEDVREYHTTDSVNF 1948
             TYT++GI+EEV +TTL++TELP+R+WTQDYK+FLES+      FI++ ++Y    +V+F
Sbjct: 892  VTYTISGIVEEVDETTLKITELPIRRWTQDYKEFLESVITANDSFIKEFKQYSDDRTVHF 951

Query: 1947 EIDLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSIRFE 1768
            E+ ++EENM +AKQEGL+KKFKLTTT+STSNMHLFDS+G+IKKYDTPE+IL++F+ +R E
Sbjct: 952  EVFMTEENMMLAKQEGLMKKFKLTTTVSTSNMHLFDSRGMIKKYDTPEEILDEFYHLRLE 1011

Query: 1767 FYEKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPFPKK 1588
            FYEKR+K ++D LE ELL ++NKVRFI+DVV+G I+V+NR+RADL LEL+EKGFTPFPKK
Sbjct: 1012 FYEKRRKHMLDTLELELLKMDNKVRFILDVVKGNIIVNNRKRADLFLELQEKGFTPFPKK 1071

Query: 1587 AKTTEISVAGSTDVPEETEENSDMASQGVRASDYDYLLSMSIGSLTIEKVQELCNNRDKL 1408
             K  E++VAG  D   E E    ++ +  RASDYDYLLSM+IG+LT+EKVQELC++RDKL
Sbjct: 1072 TKAVEVAVAGDIDHEGEPE----LSPEATRASDYDYLLSMAIGTLTLEKVQELCSDRDKL 1127

Query: 1407 IQEVEEMRKATINSLWTKDLDALERELDEQDRRDALTEEEAMEIKAK----TRRASKP-A 1243
              EVEE+RK T  SLW KDL+ LE++LDEQD+ D   EEE  + +AK     ++A +P A
Sbjct: 1128 EHEVEELRKHTPKSLWLKDLEELEKQLDEQDQADLEAEEENSKNRAKGGVAGKKARRPVA 1187

Query: 1242 TKNPRKNNKKISKTESAAEPMEISTNSEIETVSANIGPFPPSDNARVAVQKKAPRKGKSV 1063
            +KNP+K NKK     S A  +  +T  E E   A + P       R   +KK  +     
Sbjct: 1188 SKNPKKVNKKDDPQVSEASEISSTTAMEAEKAPAVVKP-----KGRAGAKKKTKKDDSDD 1242

Query: 1062 AALKDEEDDDEILALNERIAAYNLDSSPDHAEAPEAEVSEVQIKNKGPTRKAAATKK-PL 886
                D+ DD +I  L ER+A +N+DSSPDH+   E E+ +     KGP ++AAATKK P+
Sbjct: 1243 D--DDDNDDFDIPDLRERLAKHNIDSSPDHSADMETEMFQEPAGKKGPAKRAAATKKNPV 1300

Query: 885  STVTXXXXXXXXXXXXXXEVIPA-EEKKKAGRKPATAKTTKPPVGAKKRGPAA-KQSQIL 712
             +++               V PA    KK GRKPA  K  KPP  AKKRGPAA KQ ++L
Sbjct: 1301 ISLSESIGEINISDGELEVVEPAPAATKKGGRKPAAPKAGKPPAAAKKRGPAAGKQQKLL 1360

Query: 711  GQKL--ITEVLQGAADSPDKKVRKMRISPFNKKSGSVLGRXXXXXXXXXXXXXXXXXXES 538
             Q L   TE  +G+  SP+KKVRKMR SPFNKKSGSVLG+                  E 
Sbjct: 1361 TQMLKPATEA-EGSGISPEKKVRKMRASPFNKKSGSVLGKTSSSSLSSMPEIESDDDEEV 1419

Query: 537  NQVVVPRARPQRANSRKATYVLSDDDSED 451
              VV PRARPQRAN  K TYV+SD ++E+
Sbjct: 1420 AVVVEPRARPQRANRTKTTYVVSDSETEE 1448


>ref|XP_008231458.1| PREDICTED: DNA topoisomerase 2 isoform X2 [Prunus mume]
          Length = 1470

 Score = 1939 bits (5024), Expect = 0.0
 Identities = 999/1475 (67%), Positives = 1159/1475 (78%), Gaps = 36/1475 (2%)
 Frame = -1

Query: 4770 KKAPLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHNQTL 4591
            KK PL +SN+ANI P           KTIE+ YQKK+QLEHILLRPDTYIGSIEKH Q L
Sbjct: 5    KKRPLQTSNSANIAPAPTDGQG----KTIEEMYQKKSQLEHILLRPDTYIGSIEKHTQIL 60

Query: 4590 WVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVYNNG 4411
            WVY+  +MV + I+YVPGLYKIFDEILVNAADNKQRD  M+++KVTID E NCISVYNNG
Sbjct: 61   WVYQNDEMVNRSISYVPGLYKIFDEILVNAADNKQRDSSMDAVKVTIDVEQNCISVYNNG 120

Query: 4410 DGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVIETA 4231
             GVPVEIHQEE VYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEF+IETA
Sbjct: 121  AGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFIIETA 180

Query: 4230 DGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVALMKK 4051
            DG+RQ+KYKQVFT NMG K++PVI+KCKESENWT+VT+KPDLSKFNMTHLEDDVVALMKK
Sbjct: 181  DGKRQKKYKQVFTNNMGKKTEPVITKCKESENWTRVTYKPDLSKFNMTHLEDDVVALMKK 240

Query: 4050 RVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAF--------RIEEKV-DRWEVC 3898
            RVID+AGCLGK VKVELNG+ + V+SF DY +LYL+SA         R+ EKV DRWE+C
Sbjct: 241  RVIDLAGCLGKTVKVELNGKRVPVKSFLDYVDLYLQSACKSRDTPLPRMTEKVNDRWEIC 300

Query: 3897 VSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYVNKKRKNANLKPHSVRNHLW 3718
            VSLSDGQFQQVSFVN I+TIKGGTHVDYVTNQI  H+   VNKK KNANLK H+V+N+LW
Sbjct: 301  VSLSDGQFQQVSFVNGIATIKGGTHVDYVTNQITNHVMNIVNKKNKNANLKAHNVKNYLW 360

Query: 3717 VFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVANSEIVNNILEWAEFKEKK 3538
            VFVN LIDNPAFDSQTKETLT+R  SFGS+C+L+  FL+KVA S IV+++L WA FK+ K
Sbjct: 361  VFVNALIDNPAFDSQTKETLTIRPNSFGSKCELTPAFLTKVAKSGIVDSLLSWANFKQNK 420

Query: 3537 DLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGRDHYG 3358
            DLKKTDGTK++R+  + KL DAN AGG+NSEKCTLILTEGDSA  LA+AGL+VVGRDHYG
Sbjct: 421  DLKKTDGTKTERVHNINKLEDANLAGGKNSEKCTLILTEGDSAKALAMAGLAVVGRDHYG 480

Query: 3357 VFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTDQDHD 3178
            VFPLRGKLLNVR+AS  Q+ DN EI+NIK+ILGLQ  K+Y S+KSLRYG LMIMTDQDHD
Sbjct: 481  VFPLRGKLLNVREASATQVRDNEEIKNIKRILGLQQDKEYTSLKSLRYGSLMIMTDQDHD 540

Query: 3177 GSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKRSFYTMPEYESWKESLG 2998
            GSHIKGLLINFIHSFWPSLL+IPSFLVEFITPIVKATHKNG+  +FY+MPEYE+WKESL 
Sbjct: 541  GSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHKNGKSLAFYSMPEYEAWKESLR 600

Query: 2997 DKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKKKIEARK 2818
              A  WSIKYYKGLGTST KEG++YF++L  HKKDF+W D+ DGEAIELAFSKKKIE RK
Sbjct: 601  GNASGWSIKYYKGLGTSTSKEGRDYFQNLAMHKKDFIWIDERDGEAIELAFSKKKIEERK 660

Query: 2817 NWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRKILFCAF 2638
            NWLRQFEP  +LDQ++KLIKY DFV+KELI FS+ADLQRSIPSMVDGLKPGQRKILFC+F
Sbjct: 661  NWLRQFEPSVHLDQKEKLIKYSDFVHKELIQFSMADLQRSIPSMVDGLKPGQRKILFCSF 720

Query: 2637 KRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNGQFGTRN 2458
            KRNFV EAKV QF+GYVSEHSAYHHGEQSLASTIIGMAQ YVGSNNIN+L+PNGQFGTRN
Sbjct: 721  KRNFVKEAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQDYVGSNNINLLQPNGQFGTRN 780

Query: 2457 QGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVVLVNGSE 2278
             GGKDHASARYI+T+LS ITRFLFPKDDD LLDY NEDGQ+IEPTWYVPIIP VLVNGSE
Sbjct: 781  LGGKDHASARYIYTRLSPITRFLFPKDDDRLLDYLNEDGQSIEPTWYVPIIPTVLVNGSE 840

Query: 2277 GIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAGATYTVT 2098
            GIGTGWSS++PNYNPRDI+ANVR +L  E M PMDPWY+GF GTIEKT  KE+G +YTV 
Sbjct: 841  GIGTGWSSYIPNYNPRDIVANVRRLLNGEAMVPMDPWYRGFAGTIEKT-VKESGVSYTVC 899

Query: 2097 GIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY--------PFIEDVREYHTTDSVNFEI 1942
            G+IEE ++TT+R++ELP+R+WTQDYK+FLES+         PFIE   ++    +V+  +
Sbjct: 900  GVIEEGNETTVRISELPIRRWTQDYKEFLESISQGNDKAKDPFIEGFTQHSDHSTVDIIV 959

Query: 1941 DLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSIRFEFY 1762
             L EEN+  A+QEGLLKKFKLTT+ISTSNMHLFD KGVIKKYDTPE+ILE+FF +R EFY
Sbjct: 960  HLPEENLMAARQEGLLKKFKLTTSISTSNMHLFDPKGVIKKYDTPEQILEEFFHLRLEFY 1019

Query: 1761 EKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPFPKKAK 1582
            EKRKK L+DNLE ELL LENKVRFI+ VV G+I+VSNRRRADL LEL++KGFTPFPKK K
Sbjct: 1020 EKRKKVLLDNLEMELLKLENKVRFILAVVNGEIIVSNRRRADLFLELQQKGFTPFPKKTK 1079

Query: 1581 TTEISVAGSTDVPEETEENSDMAS-QGVRASDYDYLLSMSIGSLTIEKVQELCNNRDKLI 1405
              E  VAG+ +  EETEENS+ AS  G R SDY+YL+SM+IG+LTIE+VQ LC +RDK+ 
Sbjct: 1080 AQEPEVAGAIEDTEETEENSESASGNGARISDYEYLISMAIGTLTIERVQALCADRDKVN 1139

Query: 1404 QEVEEMRKATINSLWTKDLDALERELDEQDRRDALTEEEAMEIKAKTRRA-----SKPAT 1240
             EV E+R +T  SLW KDLDALE EL E ++ +AL EE   + + + + A     SKPA 
Sbjct: 1140 NEVAELRNSTPRSLWLKDLDALEMELGELEKSEALAEEAKKKSRNQVKNAPAAKVSKPAP 1199

Query: 1239 KNPRKNNKKISKTESAAEPMEISTNSEIETVSANIGPFPPSDNARV-AVQKKAP---RKG 1072
            KNPRKNNKK +  E+AAE  E S++   E   A     P     +V AV KKAP   ++ 
Sbjct: 1200 KNPRKNNKKANNAEAAAESRETSSSFVFEMEKA-----PEIVKRKVGAVAKKAPAGKKQA 1254

Query: 1071 KSVAALKDEEDDDEILALNERIAAYNLDSSPDHAEAPEAEVSEVQIKNKGPTRKAAATKK 892
            KS   L D  DDDE+L L +R+AAYNLDSSP+++   E EV +  ++ K P+++A     
Sbjct: 1255 KSAVVLSD--DDDEVLELKDRLAAYNLDSSPENSAGKETEVPQEPVQRKEPSKRA----- 1307

Query: 891  PLSTVTXXXXXXXXXXXXXXEVIPAEEKKKAGRKPATAKTTKPPVGAKKRGPAAKQSQI- 715
                                   PA  KK   +   T K +KPP  AKKRG A KQSQ  
Sbjct: 1308 -------MQIDDDEDFEVEIAAAPAAGKKGGRKAAGTTKASKPPAAAKKRGAANKQSQAS 1360

Query: 714  --LGQKLITEVLQGAAD---SPDKKVRKMRISPFNKKSGSVLGR---XXXXXXXXXXXXX 559
               GQKL+T++L+ A     SP+ KVRKMR SPFNKKSGSV+GR                
Sbjct: 1361 SSSGQKLLTDMLKPAETSGISPEPKVRKMRASPFNKKSGSVMGRESLEVEMAESEEKVDT 1420

Query: 558  XXXXXESNQVVVPRARPQRANSRKATYVLSDDDSE 454
                  S+  V  RARPQRAN R+  YVLSD +SE
Sbjct: 1421 PSTEERSDAPVAARARPQRANRRQTRYVLSDSESE 1455


>ref|XP_008231457.1| PREDICTED: DNA topoisomerase 2 isoform X1 [Prunus mume]
          Length = 1471

 Score = 1939 bits (5023), Expect = 0.0
 Identities = 997/1474 (67%), Positives = 1161/1474 (78%), Gaps = 35/1474 (2%)
 Frame = -1

Query: 4770 KKAPLTSSNNANIPPEXXXXXXXXXAKTIEQTYQKKTQLEHILLRPDTYIGSIEKHNQTL 4591
            KK PL +SN+ANI P           KTIE+ YQKK+QLEHILLRPDTYIGSIEKH Q L
Sbjct: 5    KKRPLQTSNSANIAPAPTDGQG----KTIEEMYQKKSQLEHILLRPDTYIGSIEKHTQIL 60

Query: 4590 WVYEEKQMVQKPITYVPGLYKIFDEILVNAADNKQRDPKMNSLKVTIDAEANCISVYNNG 4411
            WVY+  +MV + I+YVPGLYKIFDEILVNAADNKQRD  M+++KVTID E NCISVYNNG
Sbjct: 61   WVYQNDEMVNRSISYVPGLYKIFDEILVNAADNKQRDSSMDAVKVTIDVEQNCISVYNNG 120

Query: 4410 DGVPVEIHQEEGVYVPELIFGHLLTSSNYDDHEKKTTGGRNGYGAKLTNIFSTEFVIETA 4231
             GVPVEIHQEE VYVPELIFGHLLTSSNYDD EKKTTGGRNGYGAKLTNIFSTEF+IETA
Sbjct: 121  AGVPVEIHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFIIETA 180

Query: 4230 DGRRQRKYKQVFTCNMGNKSQPVISKCKESENWTKVTFKPDLSKFNMTHLEDDVVALMKK 4051
            DG+RQ+KYKQVFT NMG K++PVI+KCKESENWT+VT+KPDLSKFNMTHLEDDVVALMKK
Sbjct: 181  DGKRQKKYKQVFTNNMGKKTEPVITKCKESENWTRVTYKPDLSKFNMTHLEDDVVALMKK 240

Query: 4050 RVIDMAGCLGKNVKVELNGEDIRVRSFGDYCNLYLKSAF--------RIEEKV-DRWEVC 3898
            RVID+AGCLGK VKVELNG+ + V+SF DY +LYL+SA         R+ EKV DRWE+C
Sbjct: 241  RVIDLAGCLGKTVKVELNGKRVPVKSFLDYVDLYLQSACKSRDTPLPRMTEKVNDRWEIC 300

Query: 3897 VSLSDGQFQQVSFVNSISTIKGGTHVDYVTNQIATHLAEYVNKKRKNANLKPHSVRNHLW 3718
            VSLSDGQFQQVSFVN I+TIKGGTHVDYVTNQI  H+   VNKK KNANLK H+V+N+LW
Sbjct: 301  VSLSDGQFQQVSFVNGIATIKGGTHVDYVTNQITNHVMNIVNKKNKNANLKAHNVKNYLW 360

Query: 3717 VFVNCLIDNPAFDSQTKETLTLRQKSFGSECKLSDKFLSKVANSEIVNNILEWAEFKEKK 3538
            VFVN LIDNPAFDSQTKETLT+R  SFGS+C+L+  FL+KVA S IV+++L WA FK+ K
Sbjct: 361  VFVNALIDNPAFDSQTKETLTIRPNSFGSKCELTPAFLTKVAKSGIVDSLLSWANFKQNK 420

Query: 3537 DLKKTDGTKSKRITGLTKLADANNAGGRNSEKCTLILTEGDSAATLAIAGLSVVGRDHYG 3358
            DLKKTDGTK++R+  + KL DAN AGG+NSEKCTLILTEGDSA  LA+AGL+VVGRDHYG
Sbjct: 421  DLKKTDGTKTERVHNINKLEDANLAGGKNSEKCTLILTEGDSAKALAMAGLAVVGRDHYG 480

Query: 3357 VFPLRGKLLNVRDASTKQINDNAEIQNIKKILGLQHGKQYDSIKSLRYGHLMIMTDQDHD 3178
            VFPLRGKLLNVR+AS  Q+ DN EI+NIK+ILGLQ  K+Y S+KSLRYG LMIMTDQDHD
Sbjct: 481  VFPLRGKLLNVREASATQVRDNEEIKNIKRILGLQQDKEYTSLKSLRYGSLMIMTDQDHD 540

Query: 3177 GSHIKGLLINFIHSFWPSLLRIPSFLVEFITPIVKATHKNGEKRSFYTMPEYESWKESLG 2998
            GSHIKGLLINFIHSFWPSLL+IPSFLVEFITPIVKATHKNG+  +FY+MPEYE+WKESL 
Sbjct: 541  GSHIKGLLINFIHSFWPSLLKIPSFLVEFITPIVKATHKNGKSLAFYSMPEYEAWKESLR 600

Query: 2997 DKARSWSIKYYKGLGTSTDKEGKEYFKDLEKHKKDFVWADDNDGEAIELAFSKKKIEARK 2818
              A  WSIKYYKGLGTST KEG++YF++L  HKKDF+W D+ DGEAIELAFSKKKIE RK
Sbjct: 601  GNASGWSIKYYKGLGTSTSKEGRDYFQNLAMHKKDFIWIDERDGEAIELAFSKKKIEERK 660

Query: 2817 NWLRQFEPGTYLDQEDKLIKYRDFVNKELILFSIADLQRSIPSMVDGLKPGQRKILFCAF 2638
            NWLRQFEP  +LDQ++KLIKY DFV+KELI FS+ADLQRSIPSMVDGLKPGQRKILFC+F
Sbjct: 661  NWLRQFEPSVHLDQKEKLIKYSDFVHKELIQFSMADLQRSIPSMVDGLKPGQRKILFCSF 720

Query: 2637 KRNFVHEAKVGQFAGYVSEHSAYHHGEQSLASTIIGMAQQYVGSNNINILKPNGQFGTRN 2458
            KRNFV EAKV QF+GYVSEHSAYHHGEQSLASTIIGMAQ YVGSNNIN+L+PNGQFGTRN
Sbjct: 721  KRNFVKEAKVAQFSGYVSEHSAYHHGEQSLASTIIGMAQDYVGSNNINLLQPNGQFGTRN 780

Query: 2457 QGGKDHASARYIFTQLSAITRFLFPKDDDILLDYQNEDGQTIEPTWYVPIIPVVLVNGSE 2278
             GGKDHASARYI+T+LS ITRFLFPKDDD LLDY NEDGQ+IEPTWYVPIIP VLVNGSE
Sbjct: 781  LGGKDHASARYIYTRLSPITRFLFPKDDDRLLDYLNEDGQSIEPTWYVPIIPTVLVNGSE 840

Query: 2277 GIGTGWSSFVPNYNPRDIIANVRHMLRDEPMEPMDPWYKGFRGTIEKTATKEAGATYTVT 2098
            GIGTGWSS++PNYNPRDI+ANVR +L  E M PMDPWY+GF GTIEKT  KE+G +YTV 
Sbjct: 841  GIGTGWSSYIPNYNPRDIVANVRRLLNGEAMVPMDPWYRGFAGTIEKT-VKESGVSYTVC 899

Query: 2097 GIIEEVSDTTLRVTELPVRKWTQDYKDFLESLY--------PFIEDVREYHTTDSVNFEI 1942
            G+IEE ++TT+R++ELP+R+WTQDYK+FLES+         PFIE   ++    +V+  +
Sbjct: 900  GVIEEGNETTVRISELPIRRWTQDYKEFLESISQGNDKAKDPFIEGFTQHSDHSTVDIIV 959

Query: 1941 DLSEENMRIAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEKILEDFFSIRFEFY 1762
             L EEN+  A+QEGLLKKFKLTT+ISTSNMHLFD KGVIKKYDTPE+ILE+FF +R EFY
Sbjct: 960  HLPEENLMAARQEGLLKKFKLTTSISTSNMHLFDPKGVIKKYDTPEQILEEFFHLRLEFY 1019

Query: 1761 EKRKKALMDNLERELLILENKVRFIMDVVEGKIVVSNRRRADLVLELKEKGFTPFPKKAK 1582
            EKRKK L+DNLE ELL LENKVRFI+ VV G+I+VSNRRRADL LEL++KGFTPFPKK K
Sbjct: 1020 EKRKKVLLDNLEMELLKLENKVRFILAVVNGEIIVSNRRRADLFLELQQKGFTPFPKKTK 1079

Query: 1581 TTEISVAGSTDVPEETEENSDMAS-QGVRASDYDYLLSMSIGSLTIEKVQELCNNRDKLI 1405
              E  VAG+ +  EETEENS+ AS  G R SDY+YL+SM+IG+LTIE+VQ LC +RDK+ 
Sbjct: 1080 AQEPEVAGAIEDTEETEENSESASGNGARISDYEYLISMAIGTLTIERVQALCADRDKVN 1139

Query: 1404 QEVEEMRKATINSLWTKDLDALERELDEQDRRDALTEEEAMEIKAKTRRA-----SKPAT 1240
             EV E+R +T  SLW KDLDALE EL E ++ +AL EE   + + + + A     SKPA 
Sbjct: 1140 NEVAELRNSTPRSLWLKDLDALEMELGELEKSEALAEEAKKKSRNQVKNAPAAKVSKPAP 1199

Query: 1239 KNPRKNNKKISKTESAAEPMEISTNSEIETVSANIGPFPPSDNARV-AVQKKAP--RKGK 1069
            KNPRKNNKK +  E+AAE  E S++   E   A     P     +V AV KKAP  +K +
Sbjct: 1200 KNPRKNNKKANNAEAAAESRETSSSFVFEMEKA-----PEIVKRKVGAVAKKAPAGKKQQ 1254

Query: 1068 SVAALKDEEDDDEILALNERIAAYNLDSSPDHAEAPEAEVSEVQIKNKGPTRKAAATKKP 889
            + +A+   +DDDE+L L +R+AAYNLDSSP+++   E EV +  ++ K P+++A      
Sbjct: 1255 AKSAVVLSDDDDEVLELKDRLAAYNLDSSPENSAGKETEVPQEPVQRKEPSKRA------ 1308

Query: 888  LSTVTXXXXXXXXXXXXXXEVIPAEEKKKAGRKPATAKTTKPPVGAKKRGPAAKQSQI-- 715
                                  PA  KK   +   T K +KPP  AKKRG A KQSQ   
Sbjct: 1309 ------MQIDDDEDFEVEIAAAPAAGKKGGRKAAGTTKASKPPAAAKKRGAANKQSQASS 1362

Query: 714  -LGQKLITEVLQGAAD---SPDKKVRKMRISPFNKKSGSVLGR---XXXXXXXXXXXXXX 556
              GQKL+T++L+ A     SP+ KVRKMR SPFNKKSGSV+GR                 
Sbjct: 1363 SSGQKLLTDMLKPAETSGISPEPKVRKMRASPFNKKSGSVMGRESLEVEMAESEEKVDTP 1422

Query: 555  XXXXESNQVVVPRARPQRANSRKATYVLSDDDSE 454
                 S+  V  RARPQRAN R+  YVLSD +SE
Sbjct: 1423 STEERSDAPVAARARPQRANRRQTRYVLSDSESE 1456