BLASTX 2.2.25 [Feb-01-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Cornus23_contig00024994
         (565 letters)

Database: ./nr 
           77,306,371 sequences; 28,104,191,420 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gb|KJY01636.1| hypothetical protein TI39_contig285g00048 [Zymose...   139   1e-30
ref|XP_003849146.1| hypothetical protein MYCGRDRAFT_101410 [Zymo...   138   2e-30
ref|XP_013347700.1| hypothetical protein AUEXF2481DRAFT_383967 [...   122   9e-26
gb|KEQ65342.1| hypothetical protein M437DRAFT_63961 [Aureobasidi...   122   1e-25
ref|XP_013431412.1| hypothetical protein M436DRAFT_78738 [Aureob...   120   6e-25
gb|KEQ82135.1| hypothetical protein M438DRAFT_398653 [Aureobasid...   119   8e-25
ref|XP_007922720.1| hypothetical protein MYCFIDRAFT_71596 [Pseud...   116   8e-24
gb|KKY22536.1| putative ww rsp5 wwp [Diplodia seriata]                115   1e-23
gb|EKG21013.1| WW/Rsp5/WWP [Macrophomina phaseolina MS6]              114   3e-23
ref|XP_008726227.1| hypothetical protein G647_03660 [Cladophialo...   112   9e-23
ref|XP_007676498.1| hypothetical protein BAUCODRAFT_473428 [Baud...   112   9e-23
gb|KIW68250.1| hypothetical protein PV04_04207 [Capronia semiimm...   111   2e-22
gb|EMF15001.1| hypothetical protein SEPMUDRAFT_146999 [Sphaeruli...   111   2e-22
ref|XP_007757208.1| hypothetical protein A1O7_05008 [Cladophialo...   110   5e-22
ref|XP_007586921.1| putative ww rsp5 wwp protein [Neofusicoccum ...   108   2e-21
gb|KPA41520.1| hypothetical protein FLAG1_05611 [Fusarium langse...   106   7e-21
gb|EYB21444.1| hypothetical protein FG05_11946, partial [Fusariu...   106   7e-21
ref|XP_014561843.1| hypothetical protein COCVIDRAFT_11638 [Bipol...   106   7e-21
ref|XP_007712003.1| hypothetical protein COCCADRAFT_26051 [Bipol...   106   7e-21
ref|XP_011317215.1| hypothetical protein FGSG_11946 [Fusarium gr...   106   7e-21

>gb|KJY01636.1| hypothetical protein TI39_contig285g00048 [Zymoseptoria brevis]
          Length = 614

 Score =  139 bits (349), Expect = 1e-30
 Identities = 67/95 (70%), Positives = 76/95 (80%), Gaps = 1/95 (1%)
 Frame = -1

Query: 565 DQYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPPGAPPGYDNSSKPT-YGGDDKSGLHSN 389
           DQYKEWF+VNI+TKQS WE+PTEPVYP  +  P  APPGY+N +KP  + GDDKS +HSN
Sbjct: 25  DQYKEWFYVNIYTKQSTWERPTEPVYPPPEGAPHDAPPGYNNDTKPNPHYGDDKSAMHSN 84

Query: 388 NPYNASNAGTAGSSMSEDERLARQLQAEEDARRND 284
           NPYNAS AG   SS SEDERLARQLQAEEDAR  +
Sbjct: 85  NPYNASAAG-GSSSTSEDERLARQLQAEEDARNGN 118


>ref|XP_003849146.1| hypothetical protein MYCGRDRAFT_101410 [Zymoseptoria tritici
           IPO323] gi|339469022|gb|EGP84122.1| hypothetical protein
           MYCGRDRAFT_101410 [Zymoseptoria tritici IPO323]
          Length = 294

 Score =  138 bits (348), Expect = 2e-30
 Identities = 66/95 (69%), Positives = 77/95 (81%), Gaps = 1/95 (1%)
 Frame = -1

Query: 565 DQYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPPGAPPGYDNSSKPT-YGGDDKSGLHSN 389
           DQYKEWF+VNI+TKQS WE+PTEPVYP  +  P  APPGY+N +KP  + GDDKS +HSN
Sbjct: 25  DQYKEWFYVNIYTKQSTWERPTEPVYPPPEGAPHDAPPGYNNDTKPNPHYGDDKSAMHSN 84

Query: 388 NPYNASNAGTAGSSMSEDERLARQLQAEEDARRND 284
           NPYNA+ AG   SS+SEDERLARQLQAEEDAR  +
Sbjct: 85  NPYNANAAG-GSSSISEDERLARQLQAEEDARNGN 118


>ref|XP_013347700.1| hypothetical protein AUEXF2481DRAFT_383967 [Aureobasidium
           subglaciale EXF-2481] gi|662541619|gb|KEQ98918.1|
           hypothetical protein AUEXF2481DRAFT_383967
           [Aureobasidium subglaciale EXF-2481]
          Length = 287

 Score =  122 bits (307), Expect = 9e-26
 Identities = 58/96 (60%), Positives = 74/96 (77%), Gaps = 1/96 (1%)
 Frame = -1

Query: 565 DQYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPPGAPPGYDNSSKPTYGGDDKSGLHSNN 386
           DQYKEWFFVN++TKQSQWEKPTEP YP+    PPGAPPGYD S+   + G +KSG  SNN
Sbjct: 25  DQYKEWFFVNLYTKQSQWEKPTEPAYPSSGGAPPGAPPGYD-SNHSQHMGAEKSGYGSNN 83

Query: 385 PYNAS-NAGTAGSSMSEDERLARQLQAEEDARRNDT 281
           PY +S ++G +  ++++DE LAR+LQAEE+AR   T
Sbjct: 84  PYGSSIHSGGSAHNVNDDEALARKLQAEEEARARQT 119


>gb|KEQ65342.1| hypothetical protein M437DRAFT_63961 [Aureobasidium melanogenum CBS
           110374]
          Length = 319

 Score =  122 bits (306), Expect = 1e-25
 Identities = 58/93 (62%), Positives = 70/93 (75%), Gaps = 2/93 (2%)
 Frame = -1

Query: 565 DQYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPPGAPPGYDNSSKPTYGGDDKSGLHSNN 386
           DQYKEWF+VN+HTKQSQWEKPTEP YP+    PPGAPPGYD S +P   G +K G  SNN
Sbjct: 43  DQYKEWFYVNLHTKQSQWEKPTEPAYPSSGGPPPGAPPGYD-SHQPQNTGPEKGGYASNN 101

Query: 385 PYNASNAGTAGSS--MSEDERLARQLQAEEDAR 293
           PY  S+  + GSS  +++DE  AR+LQAEE+AR
Sbjct: 102 PYGGSSIHSGGSSHNVNDDEAFARKLQAEEEAR 134


>ref|XP_013431412.1| hypothetical protein M436DRAFT_78738 [Aureobasidium namibiae CBS
           147.97] gi|662519451|gb|KEQ77010.1| hypothetical protein
           M436DRAFT_78738 [Aureobasidium namibiae CBS 147.97]
          Length = 304

 Score =  120 bits (300), Expect = 6e-25
 Identities = 55/92 (59%), Positives = 72/92 (78%), Gaps = 1/92 (1%)
 Frame = -1

Query: 565 DQYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPPGAPPGYDNSSKPTYGGDDKSGLHSNN 386
           DQYK+WFFVN+HTKQSQWEKPTEP Y +    PPGAPPGYD+ ++  Y G +K G  SNN
Sbjct: 25  DQYKQWFFVNLHTKQSQWEKPTEPAYASSGGAPPGAPPGYDH-NQSQYTGPEKGGYGSNN 83

Query: 385 PYNAS-NAGTAGSSMSEDERLARQLQAEEDAR 293
           PY +S ++G +  ++++DE LAR+LQAEE+AR
Sbjct: 84  PYGSSIHSGGSAHNVNDDEALARKLQAEEEAR 115


>gb|KEQ82135.1| hypothetical protein M438DRAFT_398653 [Aureobasidium pullulans
           EXF-150]
          Length = 301

 Score =  119 bits (299), Expect = 8e-25
 Identities = 60/99 (60%), Positives = 76/99 (76%), Gaps = 4/99 (4%)
 Frame = -1

Query: 565 DQYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPPGAPPGYDNSSKPTYGGDDKSGLHSNN 386
           DQYKEWFFVN++TKQSQWEKPTEP YP+    PPGAPPGYD S++  Y G +K    SNN
Sbjct: 25  DQYKEWFFVNLYTKQSQWEKPTEPAYPSSGGAPPGAPPGYD-SNRTQYTGPEKGNYASNN 83

Query: 385 PYNAS--NAGTAGS--SMSEDERLARQLQAEEDARRNDT 281
           PY +S  N+G AGS  ++++DE LAR+LQAEE+AR + +
Sbjct: 84  PYGSSGINSG-AGSAHNINDDEALARKLQAEEEARAHQS 121


>ref|XP_007922720.1| hypothetical protein MYCFIDRAFT_71596 [Pseudocercospora fijiensis
           CIRAD86] gi|452987108|gb|EME86864.1| hypothetical
           protein MYCFIDRAFT_71596 [Pseudocercospora fijiensis
           CIRAD86]
          Length = 291

 Score =  116 bits (290), Expect = 8e-24
 Identities = 64/100 (64%), Positives = 74/100 (74%), Gaps = 4/100 (4%)
 Frame = -1

Query: 565 DQYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPP-GAPPGYDNS-SKPTYGGDDKSGLHS 392
           DQYKEWF+VN HTKQSQW+KPTE  + T    PP GAPPGYD+S SK T  G +K  L S
Sbjct: 25  DQYKEWFYVNTHTKQSQWDKPTEAAHATSGDAPPGGAPPGYDHSQSKST--GPEKPALGS 82

Query: 391 NNPYNASNAGTAGSS--MSEDERLARQLQAEEDARRNDTA 278
           NNP+N + AG AGSS  +SEDERLARQLQ EEDAR   ++
Sbjct: 83  NNPFNGT-AGGAGSSHAVSEDERLARQLQQEEDARAQQSS 121


>gb|KKY22536.1| putative ww rsp5 wwp [Diplodia seriata]
          Length = 313

 Score =  115 bits (289), Expect = 1e-23
 Identities = 56/96 (58%), Positives = 69/96 (71%), Gaps = 6/96 (6%)
 Frame = -1

Query: 562 QYKEWFFVNIHTKQSQWEKPTEPVYPTHD----SVPPGAPPGYDNSSKPTYGGDDKSGLH 395
           QY+EWF+VNI+TKQSQW+KPTEP+YP ++    + PPG PP Y +       G +K+GL 
Sbjct: 26  QYQEWFYVNIYTKQSQWDKPTEPIYPPYEAEGSAPPPGPPPSYGHGGDARPLGPEKTGLS 85

Query: 394 SNNPYNASNAGTAGS--SMSEDERLARQLQAEEDAR 293
           SNNPY     G  GS  ++SEDERLARQLQAEEDAR
Sbjct: 86  SNNPYGPGGGGYGGSGQNISEDERLARQLQAEEDAR 121


>gb|EKG21013.1| WW/Rsp5/WWP [Macrophomina phaseolina MS6]
          Length = 370

 Score =  114 bits (285), Expect = 3e-23
 Identities = 58/94 (61%), Positives = 72/94 (76%), Gaps = 3/94 (3%)
 Frame = -1

Query: 565 DQYKEWFFVNIHTKQSQWEKPTEPVYPTHD--SVPPGAPPGYDNS-SKPTYGGDDKSGLH 395
           +QY EWF+VNI+TKQSQWEKPTEP+YP  +  + PPG PP Y +S ++P   G +K+GL 
Sbjct: 86  EQYHEWFYVNIYTKQSQWEKPTEPIYPPSEGGAPPPGPPPSYTHSDARPV--GPEKTGLS 143

Query: 394 SNNPYNASNAGTAGSSMSEDERLARQLQAEEDAR 293
           SNNPY    AG++   +SEDERLARQLQAEEDAR
Sbjct: 144 SNNPYGPGPAGSS-HDISEDERLARQLQAEEDAR 176


>ref|XP_008726227.1| hypothetical protein G647_03660 [Cladophialophora carrionii CBS
           160.54] gi|565935062|gb|ETI24291.1| hypothetical protein
           G647_03660 [Cladophialophora carrionii CBS 160.54]
          Length = 283

 Score =  112 bits (281), Expect = 9e-23
 Identities = 54/91 (59%), Positives = 61/91 (67%)
 Frame = -1

Query: 565 DQYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPPGAPPGYDNSSKPTYGGDDKSGLHSNN 386
           DQYKEWF+VN+HTKQS WEKPT P     D VPPGAPPGY +        D K  L SNN
Sbjct: 25  DQYKEWFYVNLHTKQSTWEKPTGPAPGGDDEVPPGAPPGYSSGGNAPAVSDTKRPLESNN 84

Query: 385 PYNASNAGTAGSSMSEDERLARQLQAEEDAR 293
           PYN SN    GSS   DE++AR+LQAEE +R
Sbjct: 85  PYNTSN---TGSSQESDEQMARRLQAEESSR 112


>ref|XP_007676498.1| hypothetical protein BAUCODRAFT_473428 [Baudoinia panamericana UAMH
           10762] gi|449300395|gb|EMC96407.1| hypothetical protein
           BAUCODRAFT_473428 [Baudoinia panamericana UAMH 10762]
          Length = 252

 Score =  112 bits (281), Expect = 9e-23
 Identities = 58/99 (58%), Positives = 72/99 (72%), Gaps = 1/99 (1%)
 Frame = -1

Query: 565 DQYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPPGAPPGYD-NSSKPTYGGDDKSGLHSN 389
           + YKEWF+VN +TKQS WEKPTEP +P  D+ PPGAPPGYD +SS+P     +KSGL +N
Sbjct: 25  ESYKEWFYVNTYTKQSTWEKPTEPAHPPGDAPPPGAPPGYDHSSSRPPV--PEKSGLQTN 82

Query: 388 NPYNASNAGTAGSSMSEDERLARQLQAEEDARRNDTANR 272
           NPY+    G     ++EDERLAR+LQ EE+AR   TANR
Sbjct: 83  NPYHQPGQG----GLTEDERLARKLQEEENARAG-TANR 116


>gb|KIW68250.1| hypothetical protein PV04_04207 [Capronia semiimmersa]
          Length = 306

 Score =  111 bits (278), Expect = 2e-22
 Identities = 55/91 (60%), Positives = 61/91 (67%)
 Frame = -1

Query: 565 DQYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPPGAPPGYDNSSKPTYGGDDKSGLHSNN 386
           DQYKEWF+VN+HTKQS WEKPT P     D  PPGAPPGY   S      D K  L SNN
Sbjct: 25  DQYKEWFYVNLHTKQSTWEKPTGPAPGGDDEAPPGAPPGYSAGSNAPQVSDTKRPLESNN 84

Query: 385 PYNASNAGTAGSSMSEDERLARQLQAEEDAR 293
           PYN+S   T GSS   DE+LAR+LQAEE +R
Sbjct: 85  PYNSS---TTGSSHETDEQLARRLQAEESSR 112


>gb|EMF15001.1| hypothetical protein SEPMUDRAFT_146999 [Sphaerulina musiva SO2202]
          Length = 293

 Score =  111 bits (278), Expect = 2e-22
 Identities = 51/90 (56%), Positives = 64/90 (71%)
 Frame = -1

Query: 562 QYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPPGAPPGYDNSSKPTYGGDDKSGLHSNNP 383
           QY EWF+VN HT  SQWEKPTEPV+    + PPGAPPGYD+S+    G +    L+SNNP
Sbjct: 26  QYSEWFYVNTHTGVSQWEKPTEPVFGAAGAPPPGAPPGYDHSTAQATGPEKGGYLNSNNP 85

Query: 382 YNASNAGTAGSSMSEDERLARQLQAEEDAR 293
           Y  S   T  +++SEDE+LAR+LQ EE+AR
Sbjct: 86  YAGSGGATGSNNISEDEKLARKLQEEENAR 115


>ref|XP_007757208.1| hypothetical protein A1O7_05008 [Cladophialophora yegresii CBS
           114405] gi|589977571|gb|EXJ60855.1| hypothetical protein
           A1O7_05008 [Cladophialophora yegresii CBS 114405]
          Length = 297

 Score =  110 bits (275), Expect = 5e-22
 Identities = 53/91 (58%), Positives = 58/91 (63%)
 Frame = -1

Query: 565 DQYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPPGAPPGYDNSSKPTYGGDDKSGLHSNN 386
           DQYKEWF+VN+HTKQS WEKPT P     D  PPGAPPGY          D K  L SNN
Sbjct: 25  DQYKEWFYVNLHTKQSTWEKPTAPAPGGDDEAPPGAPPGYSAGGNAPAASDTKRPLESNN 84

Query: 385 PYNASNAGTAGSSMSEDERLARQLQAEEDAR 293
           PYN S    AGSS   DE +AR+LQAEE +R
Sbjct: 85  PYNTSQ--NAGSSQESDEAMARRLQAEESSR 113


>ref|XP_007586921.1| putative ww rsp5 wwp protein [Neofusicoccum parvum UCRNP2]
           gi|485919190|gb|EOD45601.1| putative ww rsp5 wwp protein
           [Neofusicoccum parvum UCRNP2]
          Length = 283

 Score =  108 bits (269), Expect = 2e-21
 Identities = 57/101 (56%), Positives = 70/101 (69%), Gaps = 5/101 (4%)
 Frame = -1

Query: 565 DQYKEWFFVNIHTKQSQWEKPTEPVYPTHD----SVPPGAPPGY-DNSSKPTYGGDDKSG 401
           +QY EWF+VNI+TKQSQWEKPTEP+YP  D    + P G PP Y    +KP   G +K+G
Sbjct: 13  EQYHEWFYVNIYTKQSQWEKPTEPIYPPSDAELGAPPAGPPPSYAHGDAKPV--GAEKTG 70

Query: 400 LHSNNPYNASNAGTAGSSMSEDERLARQLQAEEDARRNDTA 278
           L SNNP+   + G +   +SEDERLARQLQAEEDAR +  A
Sbjct: 71  LSSNNPF--GSGGGSSHDISEDERLARQLQAEEDARAHGGA 109


>gb|KPA41520.1| hypothetical protein FLAG1_05611 [Fusarium langsethiae]
          Length = 315

 Score =  106 bits (265), Expect = 7e-21
 Identities = 51/91 (56%), Positives = 59/91 (64%)
 Frame = -1

Query: 565 DQYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPPGAPPGYDNSSKPTYGGDDKSGLHSNN 386
           DQYKEWF+VNI+TKQSQWEKPT PV+P+ D  P G PPGY+  + P      K      N
Sbjct: 28  DQYKEWFYVNIYTKQSQWEKPTAPVFPSDDGAPAGPPPGYEPGNTPIVTDTKK------N 81

Query: 385 PYNASNAGTAGSSMSEDERLARQLQAEEDAR 293
           PY    A   GSS  ED +LA +LQAEEDAR
Sbjct: 82  PYEDVTASAGGSSQDEDAKLAARLQAEEDAR 112


>gb|EYB21444.1| hypothetical protein FG05_11946, partial [Fusarium graminearum]
          Length = 307

 Score =  106 bits (265), Expect = 7e-21
 Identities = 50/91 (54%), Positives = 59/91 (64%)
 Frame = -1

Query: 565 DQYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPPGAPPGYDNSSKPTYGGDDKSGLHSNN 386
           DQYKEWF+VN++TKQSQWEKPT PV+P+ D  P G PPGY+  + P      K      N
Sbjct: 23  DQYKEWFYVNVYTKQSQWEKPTAPVFPSDDGAPAGPPPGYEPGNTPVVTDTKK------N 76

Query: 385 PYNASNAGTAGSSMSEDERLARQLQAEEDAR 293
           PY    A   GSS  ED +LA +LQAEEDAR
Sbjct: 77  PYEDVTANAGGSSQDEDAKLAARLQAEEDAR 107


>ref|XP_014561843.1| hypothetical protein COCVIDRAFT_11638 [Bipolaris victoriae FI3]
           gi|578494991|gb|EUN32375.1| hypothetical protein
           COCVIDRAFT_11638 [Bipolaris victoriae FI3]
          Length = 288

 Score =  106 bits (265), Expect = 7e-21
 Identities = 54/103 (52%), Positives = 69/103 (66%), Gaps = 7/103 (6%)
 Frame = -1

Query: 562 QYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPPGAPPGYDNSSK-------PTYGGDDKS 404
           QY EWF+VN++TKQSQWEKPT+PVYP  ++ PPGAPP Y + S        PT GG +K 
Sbjct: 26  QYNEWFYVNVYTKQSQWEKPTQPVYPPGEAPPPGAPPNYVSPSAGGAVGGFPT-GGSEKG 84

Query: 403 GLHSNNPYNASNAGTAGSSMSEDERLARQLQAEEDARRNDTAN 275
            L SNNPY         +++SEDE+LAR+LQ EE+AR    +N
Sbjct: 85  SLGSNNPY---------ANISEDEKLARKLQQEEEARARGASN 118


>ref|XP_007712003.1| hypothetical protein COCCADRAFT_26051 [Bipolaris zeicola 26-R-13]
           gi|576919519|gb|EUC33692.1| hypothetical protein
           COCCADRAFT_26051 [Bipolaris zeicola 26-R-13]
          Length = 288

 Score =  106 bits (265), Expect = 7e-21
 Identities = 54/103 (52%), Positives = 69/103 (66%), Gaps = 7/103 (6%)
 Frame = -1

Query: 562 QYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPPGAPPGYDNSSK-------PTYGGDDKS 404
           QY EWF+VN++TKQSQWEKPT+PVYP  ++ PPGAPP Y + S        PT GG +K 
Sbjct: 26  QYNEWFYVNVYTKQSQWEKPTQPVYPPGEAPPPGAPPNYVSPSAGGAVGGFPT-GGSEKG 84

Query: 403 GLHSNNPYNASNAGTAGSSMSEDERLARQLQAEEDARRNDTAN 275
            L SNNPY         +++SEDE+LAR+LQ EE+AR    +N
Sbjct: 85  SLGSNNPY---------ANISEDEKLARKLQQEEEARARGASN 118


>ref|XP_011317215.1| hypothetical protein FGSG_11946 [Fusarium graminearum PH-1]
           gi|558856647|gb|ESU06730.1| hypothetical protein
           FGSG_11946 [Fusarium graminearum PH-1]
           gi|699042558|emb|CEF73545.1| unnamed protein product
           [Fusarium graminearum]
          Length = 312

 Score =  106 bits (265), Expect = 7e-21
 Identities = 50/91 (54%), Positives = 59/91 (64%)
 Frame = -1

Query: 565 DQYKEWFFVNIHTKQSQWEKPTEPVYPTHDSVPPGAPPGYDNSSKPTYGGDDKSGLHSNN 386
           DQYKEWF+VN++TKQSQWEKPT PV+P+ D  P G PPGY+  + P      K      N
Sbjct: 28  DQYKEWFYVNVYTKQSQWEKPTAPVFPSDDGAPAGPPPGYEPGNTPVVTDTKK------N 81

Query: 385 PYNASNAGTAGSSMSEDERLARQLQAEEDAR 293
           PY    A   GSS  ED +LA +LQAEEDAR
Sbjct: 82  PYEDVTANAGGSSQDEDAKLAARLQAEEDAR 112