BLASTX 2.2.25 [Feb-01-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Coptis25_contig00006953
         (1837 letters)

Database: ./nr 
           23,641,837 sequences; 8,123,359,852 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

ref|XP_002285205.1| PREDICTED: zinc-binding alcohol dehydrogenas...   812   0.0  
ref|XP_002518780.1| alcohol dehydrogenase, putative [Ricinus com...   793   0.0  
ref|XP_002313845.1| predicted protein [Populus trichocarpa] gi|2...   793   0.0  
dbj|BAG16523.1| putative NADPH oxidoreductase [Capsicum chinense]     772   0.0  
ref|XP_003607997.1| 15-hydroxyprostaglandin dehydrogenase [Medic...   772   0.0  

>ref|XP_002285205.1| PREDICTED: zinc-binding alcohol dehydrogenase domain-containing
            protein 2 [Vitis vinifera] gi|297741296|emb|CBI32427.3|
            unnamed protein product [Vitis vinifera]
          Length = 634

 Score =  812 bits (2097), Expect = 0.0
 Identities = 419/593 (70%), Positives = 471/593 (79%), Gaps = 4/593 (0%)
 Frame = +2

Query: 50   MELKAGLSALITGAASGIGKAISLALAKKGIYITIVDFSEERGKEVAS----EIAKFHHN 217
            MELK GLSAL+TG ASGIGKAISLAL +KGI++T+VDFSEERGKEVAS    E AKFH  
Sbjct: 1    MELKPGLSALVTGGASGIGKAISLALGEKGIFVTVVDFSEERGKEVASLVEKENAKFH-- 58

Query: 218  TNLNFHPPAIFVKCDVTNTREVAAAFEKHLETYGGLDICINCAGISTPISFYDDKTDGTS 397
              L F P A+F++CDVTNTRE+AAAF+KHL TYGGLDIC+N AGI T   F+ D+T+ + 
Sbjct: 59   PKLGF-PSAMFIRCDVTNTRELAAAFKKHLATYGGLDICVNSAGIGTHEPFHKDQTENSG 117

Query: 398  SWRHAVNVNLVAVIDCTQRAIQAMLGGKKQGVIINMASASGLYPMLPDPIYSGXXXXXXX 577
             WR  +NVNLVAVIDCT+ AIQ M   KK GVIINM SASGLYPM  DPIYS        
Sbjct: 118  LWRRTINVNLVAVIDCTRLAIQTMQAAKKPGVIINMGSASGLYPMYVDPIYSA------- 170

Query: 578  XXXXXXXXXXXXXXXXXXXIYSGSKGGVVLFTRSLLLYKRQGIRINVLCPEFVQTDLAEK 757
                                   SKGGVVLFTRSL  YKR GIR+NVLCPEFVQT++   
Sbjct: 171  -----------------------SKGGVVLFTRSLAPYKRHGIRVNVLCPEFVQTEMGSS 207

Query: 758  VDPKFINMMGGYISMEMVVNGAFELIQDERRAGACLWITNRRGMEYWPTPTEEAKYRTKQ 937
            VD KFI +MGGY+SMEMVV GAFELI DER+AG+CLWITNRRGMEYWPTP EEAKYR   
Sbjct: 208  VDSKFIGLMGGYVSMEMVVKGAFELISDERKAGSCLWITNRRGMEYWPTPIEEAKYRLPI 267

Query: 938  PNARKVYSNIEKSYIQIPQSYEKTVVHTLSHNFRSATSIVRTSLKLPIEPHHVLVKVIYA 1117
              +R+         +QIPQS+EK VVHTLSHNFRSATSIVR  L+LPI+P HVLVK+IYA
Sbjct: 268  SKSRRKVPFKASLNLQIPQSFEKVVVHTLSHNFRSATSIVRVPLRLPIKPRHVLVKIIYA 327

Query: 1118 GVNASDVNFSSGRYFGGSDQELSSRLPFDAGFEAVGLIAALGDSVTDLKVGIPAAIMTFG 1297
            GVNASDVNFSSGRYFGG+D++L SRLPFDAGFEAVG+IAA+GDSV DLK+G PAA+M FG
Sbjct: 328  GVNASDVNFSSGRYFGGNDKDLGSRLPFDAGFEAVGIIAAVGDSVNDLKIGTPAAVMIFG 387

Query: 1298 SYSEFMMVPSKYXXXXXXXXXXXXAMLTSGLTASIALEEAAHMQSGKVVLVTAAAGGTGQ 1477
            SY+EFMMVPSK+            AMLTSGLTASIALE+A  M+SGKVVLVTAAAGGTGQ
Sbjct: 388  SYAEFMMVPSKHILPVARPDPEVVAMLTSGLTASIALEKAVQMESGKVVLVTAAAGGTGQ 447

Query: 1478 FAVQLAKLAGNKVVATCGGEEKASLLKDLGVDRVIDYKAENIKSVLRKEFPKGVDIVYES 1657
            FAVQLAKLAGN V+ATCGG+EKA LL+DLGVDRVIDYKAE+IK+VL+KEFPKGVDI+YES
Sbjct: 448  FAVQLAKLAGNTVIATCGGKEKAMLLRDLGVDRVIDYKAEDIKTVLKKEFPKGVDIIYES 507

Query: 1658 VGGEMFDLCFNALAVYGRFVVIGMISQYQGEHGWKPLNYTGLCEKILAKSQTV 1816
            VGGEMF+LC NALA YGR VVIGMISQYQG  GW+P NYTGLCEK+LAKSQTV
Sbjct: 508  VGGEMFNLCLNALATYGRLVVIGMISQYQGARGWQPSNYTGLCEKLLAKSQTV 560


>ref|XP_002518780.1| alcohol dehydrogenase, putative [Ricinus communis]
            gi|223542161|gb|EEF43705.1| alcohol dehydrogenase,
            putative [Ricinus communis]
          Length = 634

 Score =  793 bits (2048), Expect = 0.0
 Identities = 402/593 (67%), Positives = 475/593 (80%), Gaps = 4/593 (0%)
 Frame = +2

Query: 50   MELKAGLSALITGAASGIGKAISLALAKKGIYITIVDFSEERGKEVASEI----AKFHHN 217
            ME++ GLSALITGAASGIGKA+SLAL +KG+++T+VDFSEE+GKEVAS +    AKFH  
Sbjct: 1    MEIRPGLSALITGAASGIGKALSLALGEKGVFVTVVDFSEEKGKEVASLVQKQNAKFH-- 58

Query: 218  TNLNFHPPAIFVKCDVTNTREVAAAFEKHLETYGGLDICINCAGISTPISFYDDKTDGTS 397
              L F P A+F++CDVTNTR++AAAF+KH+ TYGGLDICIN AGI T I F+ D+TDGT 
Sbjct: 59   PKLEF-PTALFIRCDVTNTRDLAAAFDKHVATYGGLDICINSAGIGTSIPFHQDQTDGTR 117

Query: 398  SWRHAVNVNLVAVIDCTQRAIQAMLGGKKQGVIINMASASGLYPMLPDPIYSGXXXXXXX 577
            SWR  ++VNLV+VIDCT+ AI AM   +K GVIIN+ SASGLYPM  DPIY+        
Sbjct: 118  SWRRTIDVNLVSVIDCTRLAINAMKAAQKPGVIINLGSASGLYPMFNDPIYAA------- 170

Query: 578  XXXXXXXXXXXXXXXXXXXIYSGSKGGVVLFTRSLLLYKRQGIRINVLCPEFVQTDLAEK 757
                                   SKGGV++FTRSL+ YKRQGIRINVLCPEFV+T++  K
Sbjct: 171  -----------------------SKGGVIMFTRSLVPYKRQGIRINVLCPEFVETEMGSK 207

Query: 758  VDPKFINMMGGYISMEMVVNGAFELIQDERRAGACLWITNRRGMEYWPTPTEEAKYRTKQ 937
            V  KFI+MMGG++ M+MV+ GAFELI +E  AG+CLWITNRRGME+WPTP EEAKY    
Sbjct: 208  VSAKFIDMMGGFVPMQMVIKGAFELISNENSAGSCLWITNRRGMEFWPTPAEEAKYLLSS 267

Query: 938  PNARKVYSNIEKSYIQIPQSYEKTVVHTLSHNFRSATSIVRTSLKLPIEPHHVLVKVIYA 1117
              + K  S+     +Q+P SYEK VVHTLSHNFRSATSIVR  L+LPI P+ VL+KV+YA
Sbjct: 268  SGSSKRVSSAVPVNLQLPNSYEKIVVHTLSHNFRSATSIVRAPLRLPIGPNQVLLKVVYA 327

Query: 1118 GVNASDVNFSSGRYFGGSDQELSSRLPFDAGFEAVGLIAALGDSVTDLKVGIPAAIMTFG 1297
            GVNASDVNFSSGRYF G++++++SRLPFDAGFE VG+IAALG+SV DLKVG PAAIMTFG
Sbjct: 328  GVNASDVNFSSGRYFSGNNKDIASRLPFDAGFELVGIIAALGESVRDLKVGTPAAIMTFG 387

Query: 1298 SYSEFMMVPSKYXXXXXXXXXXXXAMLTSGLTASIALEEAAHMQSGKVVLVTAAAGGTGQ 1477
            SY+EF +VP+K+            AMLTSGLTASIALE+AA M+SGK+VLVTAAAGGTGQ
Sbjct: 388  SYAEFTVVPAKHILPVPRLDPEVVAMLTSGLTASIALEKAAQMESGKLVLVTAAAGGTGQ 447

Query: 1478 FAVQLAKLAGNKVVATCGGEEKASLLKDLGVDRVIDYKAENIKSVLRKEFPKGVDIVYES 1657
            FAVQLAKLAGN VVATCGG+EKA +LK+LGV RVIDYKAENIK+VL+KEFPKG+DI+YES
Sbjct: 448  FAVQLAKLAGNTVVATCGGKEKAMVLKELGVHRVIDYKAENIKTVLKKEFPKGIDIIYES 507

Query: 1658 VGGEMFDLCFNALAVYGRFVVIGMISQYQGEHGWKPLNYTGLCEKILAKSQTV 1816
            VGG+MFDLC NALAV+GR +VIGMISQYQGEHGWKP NYTGLCEKILAKSQTV
Sbjct: 508  VGGDMFDLCLNALAVHGRLIVIGMISQYQGEHGWKPSNYTGLCEKILAKSQTV 560


>ref|XP_002313845.1| predicted protein [Populus trichocarpa] gi|222850253|gb|EEE87800.1|
            predicted protein [Populus trichocarpa]
          Length = 634

 Score =  793 bits (2048), Expect = 0.0
 Identities = 400/593 (67%), Positives = 474/593 (79%), Gaps = 4/593 (0%)
 Frame = +2

Query: 50   MELKAGLSALITGAASGIGKAISLALAKKGIYITIVDFSEERGKEVAS----EIAKFHHN 217
            ME+K GLSA++TG ASGIG+A+SLAL +KGI++T++DFSEE+GKEVAS    E AKFH  
Sbjct: 1    MEIKPGLSAIVTGGASGIGRALSLALGEKGIFVTVIDFSEEKGKEVASLVEKENAKFH-- 58

Query: 218  TNLNFHPPAIFVKCDVTNTREVAAAFEKHLETYGGLDICINCAGISTPISFYDDKTDGTS 397
             NL F P A+F++CDV+ +R++AAAFEKH+ TYGG+DICIN AGIS PI FY+DKTDGT 
Sbjct: 59   PNLGF-PSALFIRCDVSKSRDLAAAFEKHVATYGGMDICINGAGISNPIPFYEDKTDGTH 117

Query: 398  SWRHAVNVNLVAVIDCTQRAIQAMLGGKKQGVIINMASASGLYPMLPDPIYSGXXXXXXX 577
            SW+H VNVNL+AVIDCT  AI +ML  +K GVIIN+ SASGLYPM  DPIYSG       
Sbjct: 118  SWKHTVNVNLLAVIDCTHLAINSMLAAQKPGVIINLGSASGLYPMYNDPIYSG------- 170

Query: 578  XXXXXXXXXXXXXXXXXXXIYSGSKGGVVLFTRSLLLYKRQGIRINVLCPEFVQTDLAEK 757
                                   SKGGVV+FTRSL+ YKR+GIRINVLCPEFV+T++ EK
Sbjct: 171  -----------------------SKGGVVMFTRSLVPYKRRGIRINVLCPEFVKTEMGEK 207

Query: 758  VDPKFINMMGGYISMEMVVNGAFELIQDERRAGACLWITNRRGMEYWPTPTEEAKYRTKQ 937
            +D KFI+MMGG++ M+MVV GAFELI DE +AG+CLWITNRRGMEYWPTP EEAKY  + 
Sbjct: 208  IDSKFIDMMGGFVPMKMVVKGAFELISDESKAGSCLWITNRRGMEYWPTPMEEAKYLARS 267

Query: 938  PNARKVYSNIEKSYIQIPQSYEKTVVHTLSHNFRSATSIVRTSLKLPIEPHHVLVKVIYA 1117
             N+++  S      +Q+P SYEK VV TLSHNFR+AT IVR  L+LPI  H VLVKVIYA
Sbjct: 268  SNSKRRVSYQAPVNLQLPLSYEKLVVQTLSHNFRNATRIVRVPLRLPIGSHQVLVKVIYA 327

Query: 1118 GVNASDVNFSSGRYFGGSDQELSSRLPFDAGFEAVGLIAALGDSVTDLKVGIPAAIMTFG 1297
            GVNASDVNFSSGRYF G +Q+L+S LPFD GFEAVG+IAA+G+SVTDLKVG PAA+MTFG
Sbjct: 328  GVNASDVNFSSGRYFSGKNQDLTSSLPFDVGFEAVGIIAAVGESVTDLKVGTPAALMTFG 387

Query: 1298 SYSEFMMVPSKYXXXXXXXXXXXXAMLTSGLTASIALEEAAHMQSGKVVLVTAAAGGTGQ 1477
            SY+EF +VP+K+            A+LTSG+TASIALE+   M+SG+ V+VTAAAGGTGQ
Sbjct: 388  SYTEFTVVPAKHILPVPRPDPEVVALLTSGMTASIALEKCGQMKSGEAVVVTAAAGGTGQ 447

Query: 1478 FAVQLAKLAGNKVVATCGGEEKASLLKDLGVDRVIDYKAENIKSVLRKEFPKGVDIVYES 1657
            FAVQLAKLAGN VVATCGG EKA LLK LGVDRVIDYKAE+IK+VL+KEFPKG+DI+YES
Sbjct: 448  FAVQLAKLAGNTVVATCGGNEKAILLKQLGVDRVIDYKAEDIKTVLKKEFPKGIDIIYES 507

Query: 1658 VGGEMFDLCFNALAVYGRFVVIGMISQYQGEHGWKPLNYTGLCEKILAKSQTV 1816
            VGG+MFDLC NALA++GR +VIGMISQYQGEHGW P NYTGLCEKILA+SQTV
Sbjct: 508  VGGDMFDLCLNALAMHGRLIVIGMISQYQGEHGWTPANYTGLCEKILARSQTV 560


>dbj|BAG16523.1| putative NADPH oxidoreductase [Capsicum chinense]
          Length = 633

 Score =  772 bits (1994), Expect = 0.0
 Identities = 394/593 (66%), Positives = 466/593 (78%), Gaps = 4/593 (0%)
 Frame = +2

Query: 50   MELKAGLSALITGAASGIGKAISLALAKKGIYITIVDFSEERGKEVAS----EIAKFHHN 217
            MELK GLSAL+TG ASGIGKA+SLALA+KG+++TIVDFSEE+GKEVA+    E AKFH  
Sbjct: 1    MELKPGLSALVTGGASGIGKALSLALAQKGVFVTIVDFSEEKGKEVAAVAEKECAKFHFG 60

Query: 218  TNLNFHPPAIFVKCDVTNTREVAAAFEKHLETYGGLDICINCAGISTPISFYDDKTDGTS 397
                  P  +F++CDVTNT E+ AAFEKH  TYGGLDICIN AGI   I F +D+TDG+ 
Sbjct: 61   LEF---PVVMFIRCDVTNTGELKAAFEKHFVTYGGLDICINSAGIGDIIPFRNDQTDGSK 117

Query: 398  SWRHAVNVNLVAVIDCTQRAIQAMLGGKKQGVIINMASASGLYPMLPDPIYSGXXXXXXX 577
            SWRH +NVNL+ VID T+ AIQ+M   +K GVIIN+ SASGLYPM   PIYS        
Sbjct: 118  SWRHTINVNLIGVIDSTRLAIQSMQTAQKPGVIINLGSASGLYPMYAGPIYSA------- 170

Query: 578  XXXXXXXXXXXXXXXXXXXIYSGSKGGVVLFTRSLLLYKRQGIRINVLCPEFVQTDLAEK 757
                                   SKGGVV+FTRSL  +KRQGIRINVLCPEFVQTDLA +
Sbjct: 171  -----------------------SKGGVVMFTRSLAPFKRQGIRINVLCPEFVQTDLAGQ 207

Query: 758  VDPKFINMMGGYISMEMVVNGAFELIQDERRAGACLWITNRRGMEYWPTPTEEAKYRTKQ 937
            V+P FI+ +GGY+ ME+++ GAF+LI+DE +AGACLW+T+RRG+EYWPTP EEAKYR   
Sbjct: 208  VNPSFIDQLGGYLPMELLLEGAFQLIRDESKAGACLWVTSRRGLEYWPTPAEEAKYRLPS 267

Query: 938  PNARKVYSNIEKSYIQIPQSYEKTVVHTLSHNFRSATSIVRTSLKLPIEPHHVLVKVIYA 1117
              +RK    +    ++IP S+EK VV+TLSHNFRSAT IVRT L+LP++P +VL+KVIYA
Sbjct: 268  SKSRKSLVTVPMD-LKIPHSFEKVVVNTLSHNFRSATRIVRTELRLPLKPDYVLLKVIYA 326

Query: 1118 GVNASDVNFSSGRYFGGSDQELSSRLPFDAGFEAVGLIAALGDSVTDLKVGIPAAIMTFG 1297
            GVNASDVNFSSGRYF G+ ++++S LP D+GFEAVG+IAA+GD+V +LK+G+PAAIMTFG
Sbjct: 327  GVNASDVNFSSGRYFSGNGKDVNSLLPLDSGFEAVGIIAAIGDAVRNLKIGMPAAIMTFG 386

Query: 1298 SYSEFMMVPSKYXXXXXXXXXXXXAMLTSGLTASIALEEAAHMQSGKVVLVTAAAGGTGQ 1477
             Y+EF MVP+K+            AMLTSGLTASIALE+AA M+SGKVVLVTAAAG TGQ
Sbjct: 387  GYAEFTMVPAKHILPVAKPAPEVLAMLTSGLTASIALEKAAQMESGKVVLVTAAAGATGQ 446

Query: 1478 FAVQLAKLAGNKVVATCGGEEKASLLKDLGVDRVIDYKAENIKSVLRKEFPKGVDIVYES 1657
            FAVQLAKLAGN VVATCGG EKA LLKDLGVDRVIDYKAE+IK+VL++EFPKG DIVYES
Sbjct: 447  FAVQLAKLAGNTVVATCGGNEKAKLLKDLGVDRVIDYKAEDIKAVLKEEFPKGTDIVYES 506

Query: 1658 VGGEMFDLCFNALAVYGRFVVIGMISQYQGEHGWKPLNYTGLCEKILAKSQTV 1816
            VGGEMFD+C NALAVYGR VVIGMISQYQGEHGWKP NY G+CEK+LAKSQTV
Sbjct: 507  VGGEMFDICLNALAVYGRLVVIGMISQYQGEHGWKPRNYPGICEKLLAKSQTV 559


>ref|XP_003607997.1| 15-hydroxyprostaglandin dehydrogenase [Medicago truncatula]
            gi|355509052|gb|AES90194.1| 15-hydroxyprostaglandin
            dehydrogenase [Medicago truncatula]
          Length = 633

 Score =  772 bits (1993), Expect = 0.0
 Identities = 388/590 (65%), Positives = 466/590 (78%), Gaps = 1/590 (0%)
 Frame = +2

Query: 50   MELKAGLSALITGAASGIGKAISLALAKKGIYITIVDFSEERGKEVASEIAKFHHNTNLN 229
            ME+KAGLSAL+TG ASGIGK + LALA+KG++ITIVDFSEE+G+E A+ + K +   + N
Sbjct: 1    MEIKAGLSALVTGGASGIGKGLVLALAEKGVFITIVDFSEEKGRETATLVEKINTKFHPN 60

Query: 230  FHPPAI-FVKCDVTNTREVAAAFEKHLETYGGLDICINCAGISTPISFYDDKTDGTSSWR 406
             H P++ FVKCDVTN+R++AAAFEKH+ TYGGLDICI  AGI+ PI F  D TDGT SWR
Sbjct: 61   LHHPSVLFVKCDVTNSRDLAAAFEKHVSTYGGLDICIASAGINNPIPFDKDPTDGTRSWR 120

Query: 407  HAVNVNLVAVIDCTQRAIQAMLGGKKQGVIINMASASGLYPMLPDPIYSGXXXXXXXXXX 586
            H +NVN +AV D T+ AI+AM   K+ G IIN+ SASGLYPM  DP+Y+G          
Sbjct: 121  HTLNVNFIAVFDTTRLAIKAMEALKRPGTIINLGSASGLYPMYGDPVYTG---------- 170

Query: 587  XXXXXXXXXXXXXXXXIYSGSKGGVVLFTRSLLLYKRQGIRINVLCPEFVQTDLAEKVDP 766
                                SKGGVV+FTR+L LYKRQGIRINVLCPEF++T++  KVDP
Sbjct: 171  --------------------SKGGVVMFTRALRLYKRQGIRINVLCPEFIETEMGLKVDP 210

Query: 767  KFINMMGGYISMEMVVNGAFELIQDERRAGACLWITNRRGMEYWPTPTEEAKYRTKQPNA 946
            + I+MMGG++ M+MVV GAFELI DE +AG CLWITNRRG+EYWPTP+EEAKY T+    
Sbjct: 211  RLISMMGGFVPMDMVVKGAFELITDESKAGHCLWITNRRGLEYWPTPSEEAKYLTRPTRF 270

Query: 947  RKVYSNIEKSYIQIPQSYEKTVVHTLSHNFRSATSIVRTSLKLPIEPHHVLVKVIYAGVN 1126
            R+  S  +   I++P S+EKTVVHTL+HNFR+ATSIVR  L+LPI+P+HVLVK+IYAGVN
Sbjct: 271  RRK-SEYQAPSIKLPDSFEKTVVHTLTHNFRNATSIVRAPLRLPIKPNHVLVKIIYAGVN 329

Query: 1127 ASDVNFSSGRYFGGSDQELSSRLPFDAGFEAVGLIAALGDSVTDLKVGIPAAIMTFGSYS 1306
            ASDVNFSSGRYFGG+++E ++RLPFDAGFEAVG+IAA+GDSVTDLKVG+P A MTFG Y+
Sbjct: 330  ASDVNFSSGRYFGGNNKETAARLPFDAGFEAVGIIAAVGDSVTDLKVGMPCAFMTFGGYA 389

Query: 1307 EFMMVPSKYXXXXXXXXXXXXAMLTSGLTASIALEEAAHMQSGKVVLVTAAAGGTGQFAV 1486
            EF M+PSKY            AMLTSGLTASIALE+A  M+SGKVVLVTAAAGGTGQFAV
Sbjct: 390  EFTMIPSKYALPVPRPDPEAVAMLTSGLTASIALEKAGQMESGKVVLVTAAAGGTGQFAV 449

Query: 1487 QLAKLAGNKVVATCGGEEKASLLKDLGVDRVIDYKAENIKSVLRKEFPKGVDIVYESVGG 1666
            QLAKLAGN VVATCGG  KA LLK+LGVDRVIDY +E+IK+VL+KEFPKG+DI+YESVGG
Sbjct: 450  QLAKLAGNTVVATCGGGAKAKLLKELGVDRVIDYHSEDIKTVLKKEFPKGIDIIYESVGG 509

Query: 1667 EMFDLCFNALAVYGRFVVIGMISQYQGEHGWKPLNYTGLCEKILAKSQTV 1816
            +M  LC +ALAV+GR +VIGMISQYQGE GW P  Y GLCEK+L+KSQ V
Sbjct: 510  DMLKLCLDALAVHGRLIVIGMISQYQGEKGWTPSKYPGLCEKLLSKSQAV 559