BLASTX 2.2.25 [Feb-01-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Coptis24_contig00025687
         (864 letters)

Database: ./nr 
           23,641,837 sequences; 8,123,359,852 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

ref|XP_002263650.1| PREDICTED: pentatricopeptide repeat-containi...   360   2e-97
ref|NP_194257.1| pentatricopeptide repeat-containing protein [Ar...   351   1e-94
ref|XP_002322407.1| predicted protein [Populus trichocarpa] gi|2...   348   9e-94
ref|XP_002867617.1| hypothetical protein ARALYDRAFT_354257 [Arab...   347   2e-93
ref|XP_004160887.1| PREDICTED: LOW QUALITY PROTEIN: pentatricope...   340   3e-91

>ref|XP_002263650.1| PREDICTED: pentatricopeptide repeat-containing protein At4g25270,
            chloroplastic [Vitis vinifera]
            gi|296084180|emb|CBI24568.3| unnamed protein product
            [Vitis vinifera]
          Length = 516

 Score =  360 bits (924), Expect = 2e-97
 Identities = 175/268 (65%), Positives = 213/268 (79%)
 Frame = -1

Query: 834  DSVSWNSMLTGYIHHGLMVEALDIFRGMIDDGFEPDSVAISTILSKFSSSKVAFEVHACV 655
            DSVSWNSMLTGYI HGL ++AL IFR M+  GFEPD+VAIST+++   S K+A ++H  V
Sbjct: 247  DSVSWNSMLTGYIRHGLPLQALSIFRRMLQYGFEPDAVAISTVVTGVPSLKLAGQIHGWV 306

Query: 654  LRRGHEQSLSIANSLIALYSEQGKLDEACWLFDKMVDRDVVSWNAIISGHWKHSQALEYF 475
            LRRG + +LSIANSLI LYS  GKLD+ACWLFD M +RDVVSWN+IIS H K  +A+ YF
Sbjct: 307  LRRGVQWNLSIANSLIVLYSNHGKLDQACWLFDHMPERDVVSWNSIISAHRKDLKAITYF 366

Query: 474  NQMENSNISPDSVTFVSLLSVCAHLGLVEDGRELFVKMKNRYGIKPRMEHYACMVNLLGR 295
            ++M+ +++ PD VTFVSLLS CAHLGLV+DG  LF  M+  YG+ P MEHYACMVNL GR
Sbjct: 367  SRMQKADVLPDVVTFVSLLSACAHLGLVKDGEGLFSMMREDYGMIPSMEHYACMVNLYGR 426

Query: 294  AGLINDAYDIVVKQMEFDAGPTVWGALLYACSAHGNMDVGETAAARLFDLEPDNAHNFEL 115
            AGLI +AY+I+ K+MEF+AGPTVWGALLYAC  H N+D+G+ AA  LF+LEPDN HNFEL
Sbjct: 427  AGLIEEAYEIIEKRMEFEAGPTVWGALLYACYFHHNVDIGKIAAECLFELEPDNEHNFEL 486

Query: 114  LIKIYDNAGRWDKVEKVMQSMADRGLDS 31
            L+ IY N GR + VEKV + MADRG DS
Sbjct: 487  LMNIYRNVGRLEDVEKVRKMMADRGFDS 514



 Score = 83.2 bits (204), Expect = 7e-14
 Identities = 46/143 (32%), Positives = 80/143 (55%), Gaps = 6/143 (4%)
 Frame = -1

Query: 825 SWNSMLTGYIHHGLMVEALDIFRGMIDDGFEPDSVAISTILSK---FSSSKVAFEVHACV 655
           +WNS+++GY   GL  +A+ ++  M ++G  PD      +L       S  V  EVH  V
Sbjct: 149 AWNSLISGYAELGLYEDAMALYFQMEEEGVVPDRFTFPRVLKACGGIGSISVGEEVHRHV 208

Query: 654 LRRGHEQSLSIANSLIALYSEQGKLDEACWLFDKMVDRDVVSWNAIISGHWKHS---QAL 484
           +R G      + N+L+ +Y++ G + +A  +FDK+V RD VSWN++++G+ +H    QAL
Sbjct: 209 VRCGFADDGFVLNALVDMYAKCGDIVKARKVFDKIVCRDSVSWNSMLTGYIRHGLPLQAL 268

Query: 483 EYFNQMENSNISPDSVTFVSLLS 415
             F +M      PD+V   ++++
Sbjct: 269 SIFRRMLQYGFEPDAVAISTVVT 291



 Score = 63.9 bits (154), Expect = 4e-08
 Identities = 37/134 (27%), Positives = 70/134 (52%), Gaps = 8/134 (5%)
 Frame = -1

Query: 750 IDDGFEPDSVAISTILS---KFSSSKVAFEVHACVLRRGHEQSLSIANSLIALYSEQGKL 580
           I DG   D+   S++L    +  +      +H  +      +S+++++ L+ LY+  G++
Sbjct: 71  IQDGITVDAQIFSSLLETCFQLQAFDHGIRIHRLIPTSLLRKSVALSSKLLRLYASIGRI 130

Query: 579 DEACWLFDKMV--DRDVVSWNAIISGHWK---HSQALEYFNQMENSNISPDSVTFVSLLS 415
           +EA  LFD+M   +R   +WN++ISG+ +   +  A+  + QME   + PD  TF  +L 
Sbjct: 131 EEAHRLFDQMSRRNRSAFAWNSLISGYAELGLYEDAMALYFQMEEEGVVPDRFTFPRVLK 190

Query: 414 VCAHLGLVEDGREL 373
            C  +G +  G E+
Sbjct: 191 ACGGIGSISVGEEV 204


>ref|NP_194257.1| pentatricopeptide repeat-containing protein [Arabidopsis thaliana]
            gi|75265547|sp|Q9SB36.1|PP337_ARATH RecName:
            Full=Pentatricopeptide repeat-containing protein
            At4g25270, chloroplastic; Flags: Precursor
            gi|4454015|emb|CAA23068.1| putative protein [Arabidopsis
            thaliana] gi|7269378|emb|CAB81338.1| putative protein
            [Arabidopsis thaliana] gi|332659633|gb|AEE85033.1|
            pentatricopeptide repeat-containing protein [Arabidopsis
            thaliana]
          Length = 527

 Score =  351 bits (900), Expect = 1e-94
 Identities = 164/268 (61%), Positives = 210/268 (78%)
 Frame = -1

Query: 834  DSVSWNSMLTGYIHHGLMVEALDIFRGMIDDGFEPDSVAISTILSKFSSSKVAFEVHACV 655
            D VSWNSMLTGY+HHGL+ EALDIFR M+ +G EPD VAIS++L++  S K   ++H  V
Sbjct: 260  DYVSWNSMLTGYLHHGLLHEALDIFRLMVQNGIEPDKVAISSVLARVLSFKHGRQLHGWV 319

Query: 654  LRRGHEQSLSIANSLIALYSEQGKLDEACWLFDKMVDRDVVSWNAIISGHWKHSQALEYF 475
            +RRG E  LS+AN+LI LYS++G+L +AC++FD+M++RD VSWNAIIS H K+S  L+YF
Sbjct: 320  IRRGMEWELSVANALIVLYSKRGQLGQACFIFDQMLERDTVSWNAIISAHSKNSNGLKYF 379

Query: 474  NQMENSNISPDSVTFVSLLSVCAHLGLVEDGRELFVKMKNRYGIKPRMEHYACMVNLLGR 295
             QM  +N  PD +TFVS+LS+CA+ G+VEDG  LF  M   YGI P+MEHYACMVNL GR
Sbjct: 380  EQMHRANAKPDGITFVSVLSLCANTGMVEDGERLFSLMSKEYGIDPKMEHYACMVNLYGR 439

Query: 294  AGLINDAYDIVVKQMEFDAGPTVWGALLYACSAHGNMDVGETAAARLFDLEPDNAHNFEL 115
            AG++ +AY ++V++M  +AGPTVWGALLYAC  HGN D+GE AA RLF+LEPDN HNFEL
Sbjct: 440  AGMMEEAYSMIVQEMGLEAGPTVWGALLYACYLHGNTDIGEVAAQRLFELEPDNEHNFEL 499

Query: 114  LIKIYDNAGRWDKVEKVMQSMADRGLDS 31
            LI+IY  A R + VE+V Q M DRGL++
Sbjct: 500  LIRIYSKAKRAEDVERVRQMMVDRGLET 527



 Score = 87.4 bits (215), Expect = 4e-15
 Identities = 57/219 (26%), Positives = 112/219 (51%), Gaps = 6/219 (2%)
 Frame = -1

Query: 825 SWNSMLTGYIHHGLMVEALDIFRGMIDDGFEPDSVAISTILSK---FSSSKVAFEVHACV 655
           +WNS+++GY   G   +A+ ++  M +DG +PD      +L       S ++   +H  +
Sbjct: 162 AWNSLISGYAELGQYEDAMALYFQMAEDGVKPDRFTFPRVLKACGGIGSVQIGEAIHRDL 221

Query: 654 LRRGHEQSLSIANSLIALYSEQGKLDEACWLFDKMVDRDVVSWNAIISGHWKHS---QAL 484
           ++ G    + + N+L+ +Y++ G + +A  +FD +  +D VSWN++++G+  H    +AL
Sbjct: 222 VKEGFGYDVYVLNALVVMYAKCGDIVKARNVFDMIPHKDYVSWNSMLTGYLHHGLLHEAL 281

Query: 483 EYFNQMENSNISPDSVTFVSLLSVCAHLGLVEDGRELFVKMKNRYGIKPRMEHYACMVNL 304
           + F  M  + I PD    V++ SV A +   + GR+L   +  R G++  +     ++ L
Sbjct: 282 DIFRLMVQNGIEPDK---VAISSVLARVLSFKHGRQLHGWVIRR-GMEWELSVANALIVL 337

Query: 303 LGRAGLINDAYDIVVKQMEFDAGPTVWGALLYACSAHGN 187
             + G +  A  I  + +E D     W A++ A S + N
Sbjct: 338 YSKRGQLGQACFIFDQMLERDT--VSWNAIISAHSKNSN 374


>ref|XP_002322407.1| predicted protein [Populus trichocarpa] gi|222869403|gb|EEF06534.1|
           predicted protein [Populus trichocarpa]
          Length = 442

 Score =  348 bits (893), Expect = 9e-94
 Identities = 172/266 (64%), Positives = 199/266 (74%)
 Frame = -1

Query: 834 DSVSWNSMLTGYIHHGLMVEALDIFRGMIDDGFEPDSVAISTILSKFSSSKVAFEVHACV 655
           DS+SWNSMLTGYI HGL+ EAL  F  M+ DG E DSVA+STIL+  SS +VA ++H  +
Sbjct: 177 DSISWNSMLTGYIRHGLIAEALHTFHSMVHDGMELDSVAVSTILANVSSFEVAVQIHGWI 236

Query: 654 LRRGHEQSLSIANSLIALYSEQGKLDEACWLFDKMVDRDVVSWNAIISGHWKHSQALEYF 475
           +RRG E   SIANSLIA+YS   KLD A WLFD M  +D+VSWN+IIS H K  +AL YF
Sbjct: 237 VRRGMEWDFSIANSLIAVYSNGRKLDRARWLFDHMPKKDIVSWNSIISAHCKDLKALTYF 296

Query: 474 NQMENSNISPDSVTFVSLLSVCAHLGLVEDGRELFVKMKNRYGIKPRMEHYACMVNLLGR 295
             ME     PD +TFVSLLS CAHLGLV+DG  LF  MK +Y I P MEHYACMVNL GR
Sbjct: 297 ELMERDGALPDKITFVSLLSACAHLGLVKDGERLFSLMKAKYQINPIMEHYACMVNLYGR 356

Query: 294 AGLINDAYDIVVKQMEFDAGPTVWGALLYACSAHGNMDVGETAAARLFDLEPDNAHNFEL 115
           AGLIN+AY I+  QMEF+AGPTVWGALLY+C  H N+D GE AA  LFDLEPDN HNFEL
Sbjct: 357 AGLINEAYAIIRDQMEFEAGPTVWGALLYSCYLHRNVDTGEIAAQYLFDLEPDNEHNFEL 416

Query: 114 LIKIYDNAGRWDKVEKVMQSMADRGL 37
           L+KIYDNAGR +  E+V + M DRGL
Sbjct: 417 LMKIYDNAGRLEDAERVRKMMVDRGL 442



 Score = 76.6 bits (187), Expect = 7e-12
 Identities = 40/142 (28%), Positives = 79/142 (55%), Gaps = 6/142 (4%)
 Frame = -1

Query: 822 WNSMLTGYIHHGLMVEALDIFRGMIDDGFEPDSVAISTILSKFSSS---KVAFEVHACVL 652
           WNS++ GY   GL  +A+ ++  M ++G EPD      +L         ++   VH  ++
Sbjct: 80  WNSLIAGYTESGLYEDAMALYFQMEEEGVEPDQFTFPRVLKACGGIGLIRIGEAVHRDLV 139

Query: 651 RRGHEQSLSIANSLIALYSEQGKLDEACWLFDKMVDRDVVSWNAIISGHWKH---SQALE 481
           R G      + N+L+ +Y++ G + +A  +FDK+  +D +SWN++++G+ +H   ++AL 
Sbjct: 140 RLGFANDGFVLNALVDMYAKCGDIVKARRIFDKIDCKDSISWNSMLTGYIRHGLIAEALH 199

Query: 480 YFNQMENSNISPDSVTFVSLLS 415
            F+ M +  +  DSV   ++L+
Sbjct: 200 TFHSMVHDGMELDSVAVSTILA 221



 Score = 57.8 bits (138), Expect = 3e-06
 Identities = 33/131 (25%), Positives = 67/131 (51%), Gaps = 8/131 (6%)
 Frame = -1

Query: 750 IDDGFEPDSVAISTILS---KFSSSKVAFEVHACVLRRGHEQSLSIANSLIALYSEQGKL 580
           ++ G   D+   S++L    + ++ ++  ++H  +      ++  I++ L+ LYS  G +
Sbjct: 1   MEKGIRIDTQIFSSLLETCYRLNAIELGVKIHRLIPINLLRRNAGISSKLVRLYSSCGDV 60

Query: 579 DEACWLFDKMVDR--DVVSWNAIISGHWK---HSQALEYFNQMENSNISPDSVTFVSLLS 415
           + A  +FD+M  R      WN++I+G+ +   +  A+  + QME   + PD  TF  +L 
Sbjct: 61  EVAHQVFDEMFKRGESAFPWNSLIAGYTESGLYEDAMALYFQMEEEGVEPDQFTFPRVLK 120

Query: 414 VCAHLGLVEDG 382
            C  +GL+  G
Sbjct: 121 ACGGIGLIRIG 131


>ref|XP_002867617.1| hypothetical protein ARALYDRAFT_354257 [Arabidopsis lyrata subsp.
            lyrata] gi|297313453|gb|EFH43876.1| hypothetical protein
            ARALYDRAFT_354257 [Arabidopsis lyrata subsp. lyrata]
          Length = 758

 Score =  347 bits (891), Expect = 2e-93
 Identities = 159/268 (59%), Positives = 212/268 (79%)
 Frame = -1

Query: 834  DSVSWNSMLTGYIHHGLMVEALDIFRGMIDDGFEPDSVAISTILSKFSSSKVAFEVHACV 655
            D VSWNSMLTGY+HHGL+ EALDIFR M+ +G +PD VAIS++L++  S K   ++H  V
Sbjct: 491  DYVSWNSMLTGYLHHGLLHEALDIFRLMVQNGIDPDKVAISSVLARVLSFKHGRQLHGWV 550

Query: 654  LRRGHEQSLSIANSLIALYSEQGKLDEACWLFDKMVDRDVVSWNAIISGHWKHSQALEYF 475
            +RRG E  LS+AN+LI LYS++G+L +AC++FD+M++RD VSWNAIIS H + S   +YF
Sbjct: 551  IRRGMEWELSVANALIVLYSKRGQLGQACFIFDQMLERDTVSWNAIISAHSRDSNGFKYF 610

Query: 474  NQMENSNISPDSVTFVSLLSVCAHLGLVEDGRELFVKMKNRYGIKPRMEHYACMVNLLGR 295
             QM++++  PD +TFVS+LS+CA+ G+VEDG  LF  M   YGI P+MEHYACMVNL GR
Sbjct: 611  EQMQHADAKPDGITFVSVLSLCANTGMVEDGERLFSLMSKEYGINPKMEHYACMVNLYGR 670

Query: 294  AGLINDAYDIVVKQMEFDAGPTVWGALLYACSAHGNMDVGETAAARLFDLEPDNAHNFEL 115
            AG++ +AY ++V++MEF+AGPTVWGALLYAC  HGN D+GE +A RLF+LEPDN HNFEL
Sbjct: 671  AGMMEEAYSMIVQEMEFEAGPTVWGALLYACYLHGNTDIGEVSAQRLFELEPDNEHNFEL 730

Query: 114  LIKIYDNAGRWDKVEKVMQSMADRGLDS 31
            L++IY  A R + VE+V Q + DRGL++
Sbjct: 731  LMRIYSKAKRAEDVERVRQMLVDRGLET 758



 Score = 87.8 bits (216), Expect = 3e-15
 Identities = 67/272 (24%), Positives = 132/272 (48%), Gaps = 8/272 (2%)
 Frame = -1

Query: 840  EPDSVSWNSMLTGYIHHGLMVEALDIFRGMIDDGFEPDSVAISTILSK---FSSSKVAFE 670
            E    +WNS+++GY   G   +A+ ++  M +DG +PD      +L       S ++   
Sbjct: 388  ESSPFAWNSLISGYAELGQYEDAMALYFQMAEDGVKPDRFTFPRVLKACGGIGSVQIGEA 447

Query: 669  VHACVLRRGHEQSLSIANSLIALYSEQGKLDEACWLFDKMVDRDVVSWNAIISGHWKHS- 493
            +H  +++ G    + + N+L+ +Y++ G + +A  +FD + ++D VSWN++++G+  H  
Sbjct: 448  IHRDLVKAGFGYDVHVLNALVDMYAKCGDIVKARNVFDMIPNKDYVSWNSMLTGYLHHGL 507

Query: 492  --QALEYFNQMENSNISPDSVTFVSLLSVCAHLGLVEDGRELFVKMKNRYGIKPRMEHYA 319
              +AL+ F  M  + I PD    V++ SV A +   + GR+L   +  R G++  +    
Sbjct: 508  LHEALDIFRLMVQNGIDPDK---VAISSVLARVLSFKHGRQLHGWVIRR-GMEWELSVAN 563

Query: 318  CMVNLLGRAGLINDAYDIVVKQMEFDAGPTVWGALLYACSAHGNMDVGETAAARL--FDL 145
             ++ L  + G +  A  I  + +E D     W A++   SAH     G     ++   D 
Sbjct: 564  ALIVLYSKRGQLGQACFIFDQMLERDT--VSWNAII---SAHSRDSNGFKYFEQMQHADA 618

Query: 144  EPDNAHNFELLIKIYDNAGRWDKVEKVMQSMA 49
            +PD    F  ++ +  N G  +  E++   M+
Sbjct: 619  KPDGI-TFVSVLSLCANTGMVEDGERLFSLMS 649


>ref|XP_004160887.1| PREDICTED: LOW QUALITY PROTEIN: pentatricopeptide repeat-containing
            protein At4g25270, chloroplastic-like [Cucumis sativus]
          Length = 489

 Score =  340 bits (871), Expect = 3e-91
 Identities = 164/268 (61%), Positives = 205/268 (76%)
 Frame = -1

Query: 834  DSVSWNSMLTGYIHHGLMVEALDIFRGMIDDGFEPDSVAISTILSKFSSSKVAFEVHACV 655
            D VSWNSMLTGY  HGL  EALDIF  MI +G+EPDSVA+ST+LS  SS K    +H  V
Sbjct: 222  DIVSWNSMLTGYTRHGLHFEALDIFDQMIQEGYEPDSVALSTLLSNISSMKFKLHIHGWV 281

Query: 654  LRRGHEQSLSIANSLIALYSEQGKLDEACWLFDKMVDRDVVSWNAIISGHWKHSQALEYF 475
            +R G E +LSIANSLI +Y++ GKL+ A WLF +M  +D+VSWN+IIS H+  ++AL YF
Sbjct: 282  IRHGVEWNLSIANSLIVMYAKCGKLNRAKWLFQQMPQKDMVSWNSIISAHFNSAEALTYF 341

Query: 474  NQMENSNISPDSVTFVSLLSVCAHLGLVEDGRELFVKMKNRYGIKPRMEHYACMVNLLGR 295
              ME+  +SPD VTFVSLLS CAHLGLV++G EL+  MK +YGI+P +EHYACMVNL GR
Sbjct: 342  EVMESLGVSPDGVTFVSLLSTCAHLGLVKEGXELYFLMKGKYGIRPTIEHYACMVNLYGR 401

Query: 294  AGLINDAYDIVVKQMEFDAGPTVWGALLYACSAHGNMDVGETAAARLFDLEPDNAHNFEL 115
            AG+I +AY I+ K ME +AGPT+WGALLYAC  H ++D+ E AA RLF+LEPDN  NFEL
Sbjct: 402  AGMIEEAYKIITKGMEIEAGPTIWGALLYACYLHSDVDIAEIAAERLFELEPDNELNFEL 461

Query: 114  LIKIYDNAGRWDKVEKVMQSMADRGLDS 31
            L+KIY NAGR +  ++V   MA+RGL+S
Sbjct: 462  LMKIYGNAGRSEDEKRVKLMMAERGLNS 489



 Score = 90.9 bits (224), Expect = 3e-16
 Identities = 49/143 (34%), Positives = 83/143 (58%), Gaps = 6/143 (4%)
 Frame = -1

Query: 825 SWNSMLTGYIHHGLMVEALDIFRGMIDDGFEPDSVAISTILSK---FSSSKVAFEVHACV 655
           +WNS+++GY   GL  +AL ++  M ++G EPD+     +L       S ++   VH  V
Sbjct: 124 AWNSLISGYAELGLYEDALALYFQMEEEGVEPDNFTFPRVLKACGGIGSIQIGEAVHRHV 183

Query: 654 LRRGHEQSLSIANSLIALYSEQGKLDEACWLFDKMVDRDVVSWNAIISG---HWKHSQAL 484
           +R G    + + N+L+ +YS+ G +  A  +FD++  +D+VSWN++++G   H  H +AL
Sbjct: 184 VRSGFAGDVFVLNALVDMYSKCGCIVRARKVFDQIEYKDIVSWNSMLTGYTRHGLHFEAL 243

Query: 483 EYFNQMENSNISPDSVTFVSLLS 415
           + F+QM      PDSV   +LLS
Sbjct: 244 DIFDQMIQEGYEPDSVALSTLLS 266



 Score = 62.8 bits (151), Expect = 1e-07
 Identities = 52/209 (24%), Positives = 99/209 (47%), Gaps = 12/209 (5%)
 Frame = -1

Query: 780 VEALDI----FRGMIDDGFEPDSVAISTILS---KFSSSKVAFEVHACVLRRGHEQSLSI 622
           ++ALD         ID+G   D    S++L    +  +      +H  +      +++ I
Sbjct: 32  IQALDAVLTDLEASIDNGLFIDPEIFSSLLELCYQLQAIHHGIRIHRLIPTNLLRRNVGI 91

Query: 621 ANSLIALYSEQGKLDEACWLFDKMVDRD--VVSWNAIISGHWK---HSQALEYFNQMENS 457
           ++ L+ LY+  G +++A  +FD+M +R+    +WN++ISG+ +   +  AL  + QME  
Sbjct: 92  SSKLLRLYASFGYMEDAHQVFDEMGNRNFSAFAWNSLISGYAELGLYEDALALYFQMEEE 151

Query: 456 NISPDSVTFVSLLSVCAHLGLVEDGRELFVKMKNRYGIKPRMEHYACMVNLLGRAGLIND 277
            + PD+ TF  +L  C  +G ++ G E   +   R G    +     +V++  + G I  
Sbjct: 152 GVEPDNFTFPRVLKACGGIGSIQIG-EAVHRHVVRSGFAGDVFVLNALVDMYSKCGCIVR 210

Query: 276 AYDIVVKQMEFDAGPTVWGALLYACSAHG 190
           A   V  Q+E+      W ++L   + HG
Sbjct: 211 ARK-VFDQIEY-KDIVSWNSMLTGYTRHG 237