BLASTX 2.2.25 [Feb-01-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Cimicifuga21_contig00011168
         (1482 letters)

Database: ./nr 
           23,641,837 sequences; 8,123,359,852 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

ref|XP_781798.3| PREDICTED: uncharacterized protein LOC576390 [S...   130   1e-27
ref|XP_001649474.1| ankyrin 2,3/unc44 [Aedes aegypti] gi|1088687...   130   1e-27
ref|XP_001181547.2| PREDICTED: serine/threonine-protein phosphat...   129   3e-27
ref|XP_003729085.1| PREDICTED: uncharacterized protein LOC752844...   128   3e-27
ref|XP_001183008.2| PREDICTED: serine/threonine-protein phosphat...   125   3e-26

>ref|XP_781798.3| PREDICTED: uncharacterized protein LOC576390 [Strongylocentrotus
            purpuratus]
          Length = 2951

 Score =  130 bits (326), Expect = 1e-27
 Identities = 147/531 (27%), Positives = 230/531 (43%), Gaps = 59/531 (11%)
 Frame = -1

Query: 1452 NNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEV---DNEGKNFLHIAAMFGVFKVVKYTL 1282
            +NG T LH ++  G L    D+ ++      EV   DN GK  LH AA    F V K+ +
Sbjct: 1501 DNGMTALHASAMQGHL----DVTKYLISQGAEVNKGDNNGKTALHFAAQEAHFDVTKHLI 1556

Query: 1281 EIKEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLL-YDPRVNKMTTNKEGKYVLDSIT 1105
                   + +NK DN G+T LH AA  GH   T CL+     VNK   +  G   L S  
Sbjct: 1557 S----QGAEVNKGDNAGDTALHSAAYMGHIDVTKCLISQGAEVNK--GDNYGMTALHSAA 1610

Query: 1104 FNYDM----------------RKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENND-S 976
            F+ ++                  AG   +     RG  +  + +       ++++N+D +
Sbjct: 1611 FSGELDITKYLISQGAELNTGDNAGKTALHSAAFRGQLDVTKYLISQGAEGNKEDNDDKT 1670

Query: 975  VLSKAVMENQLDCCKEIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKT-- 802
             L  A    QLD  K +  +  +    ++N+G  ALH AA++G L++ ++LIS GA+   
Sbjct: 1671 ALHSAAFGGQLDVTKYLISQ-GAEGNKEDNDGKTALHFAAYKGPLDVTKYLISQGAEVNK 1729

Query: 801  ---------YHANKEVESGDVE-TIPNKKFLTMVDGQGATALHSAVNGVQLEAVKLLIE- 655
                     Y A +E     ++  I     +   D  G TALH A     ++  K LI  
Sbjct: 1730 GDNNGKTALYFAAQEANLDVIKYLISQGAEVNKGDNAGETALHRAAYMGHIDVTKCLISE 1789

Query: 654  -ADSNKELLMMVTKKKATALHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQ 478
             A+ NK           TALH+A  K +L++ K L+    ++    D +G+T L  A ++
Sbjct: 1790 GAEGNKG-----NNAGKTALHFAAYKGHLDVTKCLISQGAEVNK-GDNNGKTALYFAAQE 1843

Query: 477  A---------------QQGGNTSASAKIRKFLL------KTQPSQG-KAPIGDNRW-TPL 367
            A                +G N   +A  R   +      K   S+G +   G+N   T L
Sbjct: 1844 ANLDVIKYLISQGTEVNKGDNAGETALHRAAYMGHIDVTKCLISEGAEGNKGNNACKTAL 1903

Query: 366  HYAAYKGDLNAIEDIIRYCPGCWEEVDNKKQNFLHIAVMFEHVKVVKFVLGTKEVAATVL 187
            H+AAYKG L+  + +I       +E DN  +  LH A    H+ V K+++         +
Sbjct: 1904 HFAAYKGHLDVTKCLISQGADVNKE-DNAGKTALHFAAYKGHLDVTKYLIS----QGAEV 1958

Query: 186  NGQDQDGKTPLHVAALSGNENMTLCLL-YDPRVNKTTMSREGQSVLDSITF 37
            N +D +GKT LH AA   + ++T  L+     VNK   +  G++ L S  F
Sbjct: 1959 NKEDNEGKTALHFAAQEAHLDVTKHLISQGAEVNKG--NNAGKTALHSAAF 2007



 Score =  117 bits (293), Expect = 8e-24
 Identities = 134/471 (28%), Positives = 200/471 (42%), Gaps = 22/471 (4%)
 Frame = -1

Query: 1452 NNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVDNEGKNFLHIAAMFGVFKVVKYTLEIK 1273
            NNGWT LH ++ +G L+  + +I        + DNE    LH AA+ G   V KY +   
Sbjct: 1270 NNGWTALHASAQEGHLAVTKYLIS-QGADVNKGDNEDWTALHSAALLGHLDVTKYLIS-- 1326

Query: 1272 EIDASVLNKQDNEGNTPLHVAALNGHESTTLCLL-YDPRVNKMTTNKEGKYVLDSITFNY 1096
                + + K +N+G T  H AA NGH      L+     VNK   N  GK VL S  F  
Sbjct: 1327 --QGAEVKKGNNDGRTAFHGAAFNGHLDVIKYLISQGAEVNKEDNN--GKTVLHSAAF-- 1380

Query: 1095 DMRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVLSKAVMENQLDCCKEIYRR 916
                +G   V + +     E          ++  D +  +VL  A  E  LD  K +  +
Sbjct: 1381 ----SGHLDVTKHLTSQGAE----------VNKEDNDGMTVLHFAAQEGHLDETKHLISQ 1426

Query: 915  CPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESGDVET-------- 760
              + +  ++N G   LH AA  G L++ + LIS GA+    NK   +GD           
Sbjct: 1427 -GAEVNKEDNNGKTVLHSAAFSGHLDVTKHLISQGAE---VNKGDNAGDTALHSAAYMGH 1482

Query: 759  IPNKKFL-------TMVDGQGATALHSAVNGVQLEAVKLLIE--ADSNKELLMMVTKKKA 607
            I   K+L         +   G TALH++     L+  K LI   A+ NK           
Sbjct: 1483 IDVTKYLISQGAEVNNIHDNGMTALHASAMQGHLDVTKYLISQGAEVNKG-----DNNGK 1537

Query: 606  TALHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNTSASAKIRKFL 427
            TALH+A ++ + ++ K L+    ++    D +G+T    A+  A   G+      + K L
Sbjct: 1538 TALHFAAQEAHFDVTKHLISQGAEVNK-GDNAGDT----ALHSAAYMGHID----VTKCL 1588

Query: 426  LKTQPSQGKAPIGDN-RWTPLHYAAYKGDLNAIEDIIRYCPGCWEEV---DNKKQNFLHI 259
            +       K   GDN   T LH AA+ G+L    DI +Y      E+   DN  +  LH 
Sbjct: 1589 ISQGAEVNK---GDNYGMTALHSAAFSGEL----DITKYLISQGAELNTGDNAGKTALHS 1641

Query: 258  AVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMTLCLL 106
            A     + V K+++          N +D D KT LH AA  G  ++T  L+
Sbjct: 1642 AAFRGQLDVTKYLISQGAEG----NKEDNDDKTALHSAAFGGQLDVTKYLI 1688



 Score =  114 bits (285), Expect = 7e-23
 Identities = 139/488 (28%), Positives = 204/488 (41%), Gaps = 38/488 (7%)
 Frame = -1

Query: 1455 GNN-GWTPLHHASYDGDLSAIEDIIRFCPGSWEEV---DNEGKNFLHIAAMFGVFKVVKY 1288
            GNN G T LH A+Y G L    D+ +       EV   DN GK  L+ AA      V+KY
Sbjct: 1796 GNNAGKTALHFAAYKGHL----DVTKCLISQGAEVNKGDNNGKTALYFAAQEANLDVIKY 1851

Query: 1287 TLEIKEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLLYDPRVNKMTTNK--------E 1132
             +       + +NK DN G T LH AA  GH   T CL+ +        N          
Sbjct: 1852 LIS----QGTEVNKGDNAGETALHRAAYMGHIDVTKCLISEGAEGNKGNNACKTALHFAA 1907

Query: 1131 GKYVLDS----ITFNYDMRK---AGVYGVMERVQRGDKEYFR-VVALDVLLDSRDENNDS 976
             K  LD     I+   D+ K   AG   +     +G  +  + +++    ++  D    +
Sbjct: 1908 YKGHLDVTKCLISQGADVNKEDNAGKTALHFAAYKGHLDVTKYLISQGAEVNKEDNEGKT 1967

Query: 975  VLSKAVMENQLDCCKEIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAK--- 805
             L  A  E  LD  K +  +   +    NN G  ALH AA  G+L++ ++LIS GA+   
Sbjct: 1968 ALHFAAQEAHLDVTKHLISQGAEV-NKGNNAGKTALHSAAFSGQLDVTKYLISQGAEVNK 2026

Query: 804  -------TYHANKEVESGDV--ETIPNKKFLTMVDGQGATALHSAVNGVQLEAVKLLIE- 655
                     H+   +   DV    I     L   D  G TALHSA    QL+  K LI  
Sbjct: 2027 GDNAGEPVLHSAAHMGHLDVIKYLISQGAELNTGDNSGKTALHSAAFSGQLDVTKCLISQ 2086

Query: 654  -ADSNKELLMMVTKKKATALHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQ 478
             A+ NK           TALH A    ++++ K+L+    ++    D +G T L      
Sbjct: 2087 GAEGNKG-----DNDGETALHSAAYMGHIDVTKYLISQGAEVNNIHD-NGMTAL---HAS 2137

Query: 477  AQQGGNTSASAKIRKFLLKTQPSQGKAPIGDNRW-TPLHYAAYKGDLNAIEDIIRYCPGC 301
            A QG        + K+L+       K   GDN   T LH+AA +       D+ ++    
Sbjct: 2138 AMQG-----HLDVTKYLISQGAEVNK---GDNNGKTALHFAAQEAHF----DVTKHLISQ 2185

Query: 300  WEEVD---NKKQNFLHIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGN 130
              EV+   N  +  LH A    ++ V  ++          +NG DQDG+T LH AA  G+
Sbjct: 2186 GAEVNKGRNDGKTALHKAAQEGYLDVTNYLTS----QGAEVNGGDQDGRTALHNAAYMGH 2241

Query: 129  ENMTLCLL 106
             ++T+ L+
Sbjct: 2242 LDVTIYLI 2249



 Score =  110 bits (276), Expect = 7e-22
 Identities = 127/504 (25%), Positives = 212/504 (42%), Gaps = 38/504 (7%)
 Frame = -1

Query: 1449 NGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVDN---EGKNFLHIAAMFGVFKVVKYTLE 1279
            +G T LH A+  G L    DI ++      EV+N   +G+  LH AA  G F V+KY + 
Sbjct: 127  SGRTALHSAAIRGHL----DITKYLISQGAEVNNGEIDGETALHFAAYGGHFDVIKYLIS 182

Query: 1278 IKEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLLYDPRVNKMTTNKEGKYVLDSITFN 1099
                  +V+N   N+G T LH+ A +GH   T  L+      K   N             
Sbjct: 183  ----QGAVVNNNKNDGKTALHITAFHGHLDVTKYLISQGAEVKKVDND------------ 226

Query: 1098 YDMRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVLSKAVMENQLDCCKEIYR 919
               R+  ++   +       +Y  +++    ++    +  + L  A  E  LD  K +  
Sbjct: 227  ---RRTALHCAAQEDHLQITKY--LISKGAEMNKGGNDGRTALHIAAQEGHLDVTKYLIS 281

Query: 918  RCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESGD------VETI 757
            +   +  +++N+   ALH A H+G L++ ++LIS GA       EV+ GD      +   
Sbjct: 282  QGAEM-NNRDNKSMTALHFAIHKGHLDVTKYLISQGA-------EVKKGDNDGGTVLHIA 333

Query: 756  PNKKFLTMVDGQGATALHSAVNGVQLEAVKLLIE--ADSNKELLMMVTKKKATALHWAVE 583
              +  +   DG G+T LH A     L+  K LI   A+ N+           TALH    
Sbjct: 334  AQEAEVNNRDGTGSTPLHIAAFTGHLDVAKYLISQGAEVNEG-----DNYGRTALHTIAF 388

Query: 582  KQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQA---------------QQGGNTSAS 448
            + +L++ K+ +  + D+    D  G T L +A R+                 +GGN   +
Sbjct: 389  RGHLDVTKYFISQEADVNK-EDNDGITALHIAAREGHLDVTKNLISQGADMNKGGNDGRT 447

Query: 447  A----------KIRKFLLKTQPSQGKA--PIGDNRWTPLHYAAYKGDLNAIEDIIRYCPG 304
            A           + K+L+    SQG     I  N  T L +A +KG L+  E +I     
Sbjct: 448  ALHSAALGGHLDVTKYLI----SQGAEVNNIDSNGMTALQFATHKGHLDVTEYLI----- 498

Query: 303  CWEEVDNKKQNFLHIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNEN 124
               + D   +  LH+A    H+ V K ++         +N +D +G+T L+ AA SG+ +
Sbjct: 499  --SQGDINGRTVLHVAANKGHLDVTKNLIS----QGAEVNKEDINGRTALNSAASSGHLD 552

Query: 123  MTLCLLYDPRVNKTTMSREGQSVL 52
            +T  L+     +  T   +G++ L
Sbjct: 553  VTKYLI-SQGADANTRDNDGRTAL 575



 Score =  109 bits (273), Expect = 2e-21
 Identities = 126/455 (27%), Positives = 195/455 (42%), Gaps = 6/455 (1%)
 Frame = -1

Query: 1452 NNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVDNEGKNFLHIAAMFGVFKVVKYTLEIK 1273
            N+G T LH  ++ G L   + +I       ++VDN+ +  LH AA     ++ KY +   
Sbjct: 192  NDGKTALHITAFHGHLDVTKYLISQ-GAEVKKVDNDRRTALHCAAQEDHLQITKYLIS-- 248

Query: 1272 EIDASVLNKQDNEGNTPLHVAALNGHESTTLCLLYDPRVNKMTTNKEGKYVLDSITFNY- 1096
                + +NK  N+G T LH+AA  GH   T  L+          NK    +  +I   + 
Sbjct: 249  --KGAEMNKGGNDGRTALHIAAQEGHLDVTKYLISQGAEMNNRDNKSMTALHFAIHKGHL 306

Query: 1095 DMRKAGVYGVMERVQRGDKE---YFRVVALDVLLDSRDENNDSVLSKAVMENQLDCCKEI 925
            D+ K  +    E V++GD +      + A +  +++RD    + L  A     LD  K +
Sbjct: 307  DVTKYLISQGAE-VKKGDNDGGTVLHIAAQEAEVNNRDGTGSTPLHIAAFTGHLDVAKYL 365

Query: 924  YRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESGDVETIPNKK 745
              +   +    +N G  ALH  A RG L++ ++ IS  A     NKE             
Sbjct: 366  ISQGAEV-NEGDNYGRTALHTIAFRGHLDVTKYFISQEADV---NKE------------- 408

Query: 744  FLTMVDGQGATALHSAVNGVQLEAVKLLIE--ADSNKELLMMVTKKKATALHWAVEKQNL 571
                 D  G TALH A     L+  K LI   AD NK           TALH A    +L
Sbjct: 409  -----DNDGITALHIAAREGHLDVTKNLISQGADMNKG-----GNDGRTALHSAALGGHL 458

Query: 570  EIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNTSASAKIRKFLLKTQPSQGKAPI 391
            ++ K+L+    ++    D +G T L  A  +            + ++L+    SQG    
Sbjct: 459  DVTKYLISQGAEVNNI-DSNGMTALQFATHKGH--------LDVTEYLI----SQGDI-- 503

Query: 390  GDNRWTPLHYAAYKGDLNAIEDIIRYCPGCWEEVDNKKQNFLHIAVMFEHVKVVKFVLGT 211
              N  T LH AA KG L+  +++I       +E D   +  L+ A    H+ V K+++  
Sbjct: 504  --NGRTVLHVAANKGHLDVTKNLISQGAEVNKE-DINGRTALNSAASSGHLDVTKYLISQ 560

Query: 210  KEVAATVLNGQDQDGKTPLHVAALSGNENMTLCLL 106
               A    N +D DG+T LHVAA  GN ++T  L+
Sbjct: 561  GADA----NTRDNDGRTALHVAAQKGNTDVTKYLI 591



 Score =  103 bits (257), Expect = 1e-19
 Identities = 115/434 (26%), Positives = 177/434 (40%), Gaps = 16/434 (3%)
 Frame = -1

Query: 1359 EVDNEGKNFLHIAAMFGVFKVVKYTLEIKEIDASVLNKQDNEGNTPLHVAALNGHESTTL 1180
            E DN G   LH +A  G   V KY +       + +NK DNE  T LH AAL GH   T 
Sbjct: 1267 ERDNNGWTALHASAQEGHLAVTKYLIS----QGADVNKGDNEDWTALHSAALLGHLDVTK 1322

Query: 1179 CLLYDPRVNKMTTNKEGKYVLDSITFNYDMRKAGVYGVMERVQRGDKEYFRVVALDVLLD 1000
             L+      K   N +G+       FN         G ++ ++        +++    ++
Sbjct: 1323 YLISQGAEVK-KGNNDGRTAFHGAAFN---------GHLDVIK-------YLISQGAEVN 1365

Query: 999  SRDENNDSVLSKAVMENQLDCCKEIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLI 820
              D N  +VL  A     LD  K +  +  + +  ++N+G   LH AA  G L+  + LI
Sbjct: 1366 KEDNNGKTVLHSAAFSGHLDVTKHLTSQ-GAEVNKEDNDGMTVLHFAAQEGHLDETKHLI 1424

Query: 819  SVGAKTYHANKEVESGDV---------------ETIPNKKFLTMVDGQGATALHSAVNGV 685
            S GA+    NKE  +G                   I     +   D  G TALHSA    
Sbjct: 1425 SQGAE---VNKEDNNGKTVLHSAAFSGHLDVTKHLISQGAEVNKGDNAGDTALHSAAYMG 1481

Query: 684  QLEAVKLLIEADSNKELLMMVTKKKATALHWAVEKQNLEIVKFLVETDPDMEYCADVSGE 505
             ++  K LI   +    +  +     TALH +  + +L++ K+L+    ++    D +G+
Sbjct: 1482 HIDVTKYLISQGAE---VNNIHDNGMTALHASAMQGHLDVTKYLISQGAEVNK-GDNNGK 1537

Query: 504  TPLLMAMRQAQQGGNTSASAKIRKFLLKTQPSQGKAPIGDNRW-TPLHYAAYKGDLNAIE 328
            T L  A ++A           + K L+       K   GDN   T LH AAY G ++  +
Sbjct: 1538 TALHFAAQEAH--------FDVTKHLISQGAEVNK---GDNAGDTALHSAAYMGHIDVTK 1586

Query: 327  DIIRYCPGCWEEVDNKKQNFLHIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHV 148
             +I        + DN     LH A     + + K+++         LN  D  GKT LH 
Sbjct: 1587 CLISQGAEV-NKGDNYGMTALHSAAFSGELDITKYLIS----QGAELNTGDNAGKTALHS 1641

Query: 147  AALSGNENMTLCLL 106
            AA  G  ++T  L+
Sbjct: 1642 AAFRGQLDVTKYLI 1655



 Score = 96.7 bits (239), Expect = 1e-17
 Identities = 125/492 (25%), Positives = 208/492 (42%), Gaps = 37/492 (7%)
 Frame = -1

Query: 1449 NGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVDNEGKNFLHIAAMFGVFKVVKYTLEIKE 1270
            NG T L+ A+  G L   + +I     +    DN+G+  LH+AA  G   V KY +    
Sbjct: 537  NGRTALNSAASSGHLDVTKYLISQGADA-NTRDNDGRTALHVAAQKGNTDVTKYLIS--- 592

Query: 1269 IDASVLNKQDNEGNTPLHVAALNGHESTTLCLL-----YDPRVNKMTT-----NKEG--- 1129
               + +N  D  G T LH AA +GH   T  L+      + R N   T     + EG   
Sbjct: 593  -QGAEVNNGDINGLTALHSAAFSGHLDVTKYLIRQGADVNNRENHNWTVLYLADTEGYLD 651

Query: 1128 --KYVLDS---ITFNYDMRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVLSK 964
              KY++     + +  +  +  ++   ++      +Y  +++    ++  D +  + L  
Sbjct: 652  VTKYLISQEADVNYRENQSRTALHLAAQKGHLDVTKY--LISQGAEVNKGDNDGRTALHV 709

Query: 963  AVMENQLDCCKEIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAK------- 805
            A  +   D  K +  R   +   + N+G+ ALH AA  G L++ ++LIS GA+       
Sbjct: 710  AARKGNTDVTKYLISRGADV-NKEKNDGWTALHIAAFSGHLDVTKYLISQGAEVKKGDND 768

Query: 804  ---TYHANKEVESGDVE--TIPNKKFLTMVDGQGATALHSAVNGVQLEAVKLLIE--ADS 646
                +H   +  + DV    I     +   D +G TA+HS      L+  K LI   A+ 
Sbjct: 769  GRTAFHVAAQKGNTDVTKYLISQGAEVNNGDIKGLTAIHSVAFSGHLDVTKYLISQGAEM 828

Query: 645  NKELLMMVTKKKATALHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQG 466
            NK           TALH A    +L++ K+L+    ++    D  G T L  A       
Sbjct: 829  NKG-----GNDGRTALHRAAFHGHLDVTKYLISHGAEVNK-GDNHGTTALHSAA------ 876

Query: 465  GNTSASAKIRKFLLKTQPSQGKAPIGDN-RWTPLHYAAYKGDLNAIEDIIRYCPGCWEEV 289
              +S    + K+L+       K   GD   WT LH AA++G L    DI +Y      ++
Sbjct: 877  --SSDHLDVAKYLISQGAEVNK---GDKIGWTSLHIAAFEGFL----DITKYLISQGSDL 927

Query: 288  DN---KKQNFLHIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMT 118
            +      +  LH A +  H+ V K ++    +    +N  D  G T L+VAA  G+ ++T
Sbjct: 928  NKGYINGRTALHCAAVKNHLDVTKCLI----IQGAEVNKGDNVGTTALNVAAHKGHLDVT 983

Query: 117  LCLLYD-PRVNK 85
              ++ +   VNK
Sbjct: 984  TYIISEGAEVNK 995



 Score = 93.2 bits (230), Expect = 2e-16
 Identities = 123/473 (26%), Positives = 197/473 (41%), Gaps = 24/473 (5%)
 Frame = -1

Query: 1452 NNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVDNEGKNFLHIAAMFGVFKVVKYTL--- 1282
            ++ W  LH A+++  L   + +IR       + DN+    L +AA  G   V  Y +   
Sbjct: 44   DDSWAALHSAAHESHLDIPKYLIRR-EAFVNKGDNDSLAALLMAAFSGQLDVTIYLISEG 102

Query: 1281 -EIKEID--------ASVLNKQDNEGNTPLHVAALNGHESTTLCLLYDPRVNKMTTNKEG 1129
             E+ + D         +V+NK D  G T LH AA+ GH   T  L+          N E 
Sbjct: 103  AEVNKGDIAVYLIYQGAVVNKGDISGRTALHSAAIRGHLDITKYLISQ---GAEVNNGE- 158

Query: 1128 KYVLDSITFNYDMRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVLSKAVMEN 949
               +D  T  +     G + V++           +++   ++++   +  + L       
Sbjct: 159  ---IDGETALHFAAYGGHFDVIK----------YLISQGAVVNNNKNDGKTALHITAFHG 205

Query: 948  QLDCCKEIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESGD 769
             LD  K +  +  + +   +N+   ALH AA    L + ++LIS GA       E+  G 
Sbjct: 206  HLDVTKYLISQ-GAEVKKVDNDRRTALHCAAQEDHLQITKYLISKGA-------EMNKG- 256

Query: 768  VETIPNKKFLTMVDGQGATALHSAVNGVQLEAVKLLIE--ADSNKELLMMVTKKKATALH 595
                            G TALH A     L+  K LI   A+ N         K  TALH
Sbjct: 257  -------------GNDGRTALHIAAQEGHLDVTKYLISQGAEMNNR-----DNKSMTALH 298

Query: 594  WAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQ---QGGNTSASAKIRKF-- 430
            +A+ K +L++ K+L+    +++   D  G T L +A ++A+   + G  S    I  F  
Sbjct: 299  FAIHKGHLDVTKYLISQGAEVKK-GDNDGGTVLHIAAQEAEVNNRDGTGSTPLHIAAFTG 357

Query: 429  ---LLKTQPSQG-KAPIGDNRW-TPLHYAAYKGDLNAIEDIIRYCPGCWEEVDNKKQNFL 265
               + K   SQG +   GDN   T LH  A++G L+  +  I       +E DN     L
Sbjct: 358  HLDVAKYLISQGAEVNEGDNYGRTALHTIAFRGHLDVTKYFISQEADVNKE-DNDGITAL 416

Query: 264  HIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMTLCLL 106
            HIA    H+ V K ++         +N    DG+T LH AAL G+ ++T  L+
Sbjct: 417  HIAAREGHLDVTKNLIS----QGADMNKGGNDGRTALHSAALGGHLDVTKYLI 465



 Score = 91.3 bits (225), Expect = 6e-16
 Identities = 129/495 (26%), Positives = 197/495 (39%), Gaps = 24/495 (4%)
 Frame = -1

Query: 1449 NGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVDNEGKNFLHIAAMFGVFKVVKYTLEIKE 1270
            NG T LH A++ G L   + +IR         +N     L++A   G   V KY +  +E
Sbjct: 603  NGLTALHSAAFSGHLDVTKYLIRQ-GADVNNRENHNWTVLYLADTEGYLDVTKYLIS-QE 660

Query: 1269 IDASVLNKQDNEGNTPLHVAALNGHESTTLCLLYD-PRVNKMTTNKEGKYVLDSITFNYD 1093
             D   +N ++N+  T LH+AA  GH   T  L+     VNK   + +G+  L     +  
Sbjct: 661  AD---VNYRENQSRTALHLAAQKGHLDVTKYLISQGAEVNK--GDNDGRTAL-----HVA 710

Query: 1092 MRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENND--SVLSKAVMENQLDCCKEIYR 919
             RK         + RG              D   E ND  + L  A     LD  K +  
Sbjct: 711  ARKGNTDVTKYLISRG-------------ADVNKEKNDGWTALHIAAFSGHLDVTKYLIS 757

Query: 918  RCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESGDVE---TIPNK 748
            +   +    +N+G  A H AA +G  ++ ++LIS GA       EV +GD++    I + 
Sbjct: 758  QGAEVKKG-DNDGRTAFHVAAQKGNTDVTKYLISQGA-------EVNNGDIKGLTAIHSV 809

Query: 747  KFLTMVD----------------GQGATALHSAVNGVQLEAVKLLIE--ADSNKELLMMV 622
             F   +D                  G TALH A     L+  K LI   A+ NK      
Sbjct: 810  AFSGHLDVTKYLISQGAEMNKGGNDGRTALHRAAFHGHLDVTKYLISHGAEVNKG----- 864

Query: 621  TKKKATALHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNTSASAK 442
                 TALH A    +L++ K+L+    ++    D  G T L +A  +            
Sbjct: 865  DNHGTTALHSAASSDHLDVAKYLISQGAEVNK-GDKIGWTSLHIAAFEG--------FLD 915

Query: 441  IRKFLLKTQPSQGKAPIGDNRWTPLHYAAYKGDLNAIEDIIRYCPGCWEEVDNKKQNFLH 262
            I K+L+       K  I  N  T LH AA K  L+  + +I        + DN     L+
Sbjct: 916  ITKYLISQGSDLNKGYI--NGRTALHCAAVKNHLDVTKCLIIQGAEV-NKGDNVGTTALN 972

Query: 261  IAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMTLCLLYDPRVNKT 82
            +A    H+ V  +++         +N  + DG+TPLH A  + + N+   LL +      
Sbjct: 973  VAAHKGHLDVTTYIISE----GAEVNKGNNDGRTPLHHAVQNVHINIVKVLL-EGGARSD 1027

Query: 81   TMSREGQSVLDSITF 37
            T   +G + L   TF
Sbjct: 1028 TGDIDGHTPLQMSTF 1042



 Score = 83.2 bits (204), Expect = 2e-13
 Identities = 129/494 (26%), Positives = 191/494 (38%), Gaps = 23/494 (4%)
 Frame = -1

Query: 1449 NGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVDNEGKNFLHIAAMFGVFKVVKYTLEIKE 1270
            +G  P H A+  G L A + II     + E  D +G + ++     G +    +T     
Sbjct: 1202 DGQVPWHLAASFGRLKATKVIINH-GANMETGDKDGYSAVY-KRKSGQYWHYSFTHCSLA 1259

Query: 1269 IDASVLNKQDNEGNTPLHVAALNGHESTTLCLLYDPRVNKMTTNKEGKYVLDSITFNYDM 1090
               + +N++DN G T LH +A  GH + T                  KY++         
Sbjct: 1260 RQGAGVNERDNNGWTALHASAQEGHLAVT------------------KYLISQGA----- 1296

Query: 1089 RKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVLSKAVMENQLDCCKEIYRRCP 910
                       V +GD E +                 + L  A +   LD  K +  +  
Sbjct: 1297 ----------DVNKGDNEDW-----------------TALHSAALLGHLDVTKYLISQGA 1329

Query: 909  SLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESGDVET--------IP 754
             +    NN+G  A H AA  G L+++++LIS GA+    NKE  +G            + 
Sbjct: 1330 EVKKG-NNDGRTAFHGAAFNGHLDVIKYLISQGAE---VNKEDNNGKTVLHSAAFSGHLD 1385

Query: 753  NKKFLT-------MVDGQGATALHSAVNGVQLEAVKLLIE--ADSNKELLMMVTKKKATA 601
              K LT         D  G T LH A     L+  K LI   A+ NKE          T 
Sbjct: 1386 VTKHLTSQGAEVNKEDNDGMTVLHFAAQEGHLDETKHLISQGAEVNKE-----DNNGKTV 1440

Query: 600  LHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNTSASAKIRKFLLK 421
            LH A    +L++ K L+    ++    D +G+T    A+  A   G+      + K+L+ 
Sbjct: 1441 LHSAAFSGHLDVTKHLISQGAEVNK-GDNAGDT----ALHSAAYMGHID----VTKYLI- 1490

Query: 420  TQPSQGKA--PIGDNRWTPLHYAAYKGDLNAIEDIIRYCPGCWEEV---DNKKQNFLHIA 256
               SQG     I DN  T LH +A +G L    D+ +Y      EV   DN  +  LH A
Sbjct: 1491 ---SQGAEVNNIHDNGMTALHASAMQGHL----DVTKYLISQGAEVNKGDNNGKTALHFA 1543

Query: 255  VMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMTLCLL-YDPRVNKTT 79
                H  V K ++         +N  D  G T LH AA  G+ ++T CL+     VNK  
Sbjct: 1544 AQEAHFDVTKHLIS----QGAEVNKGDNAGDTALHSAAYMGHIDVTKCLISQGAEVNKG- 1598

Query: 78   MSREGQSVLDSITF 37
                G + L S  F
Sbjct: 1599 -DNYGMTALHSAAF 1611



 Score = 81.3 bits (199), Expect = 6e-13
 Identities = 109/405 (26%), Positives = 158/405 (39%), Gaps = 59/405 (14%)
 Frame = -1

Query: 1476 SQG-KAPSGNN-GWTPLHHASYDGDLSAIEDIIRFCPGSWEEV---DNEGKNFLHIAAMF 1312
            SQG +   GNN G T LH A++ G L    D+ ++      EV   DN G+  LH AA  
Sbjct: 1986 SQGAEVNKGNNAGKTALHSAAFSGQL----DVTKYLISQGAEVNKGDNAGEPVLHSAAHM 2041

Query: 1311 GVFKVVKYTLEIKEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLLYDPRVNKMTTNKE 1132
            G   V+KY +       + LN  DN G T LH AA +G    T CL+          N +
Sbjct: 2042 GHLDVIKYLIS----QGAELNTGDNSGKTALHSAAFSGQLDVTKCLISQGAEGNKGDN-D 2096

Query: 1131 GKYVLDSITF--NYDMRKA--------------GVYGVMERVQRGDKEYFR-VVALDVLL 1003
            G+  L S  +  + D+ K               G+  +     +G  +  + +++    +
Sbjct: 2097 GETALHSAAYMGHIDVTKYLISQGAEVNNIHDNGMTALHASAMQGHLDVTKYLISQGAEV 2156

Query: 1002 DSRDENNDSVLSKAVMENQLDCCKEIYRRCPSLLYSQNN----------EGYI------- 874
            +  D N  + L  A  E   D  K +  +   +   +N+          EGY+       
Sbjct: 2157 NKGDNNGKTALHFAAQEAHFDVTKHLISQGAEVNKGRNDGKTALHKAAQEGYLDVTNYLT 2216

Query: 873  ---------------ALHHAAHRGKLNMLQFLISVGAKTYHANKEVESGDVETIPNKKFL 739
                           ALH+AA+ G L++  +LIS GA       EV +G           
Sbjct: 2217 SQGAEVNGGDQDGRTALHNAAYMGHLDVTIYLISQGA-------EVNNG----------- 2258

Query: 738  TMVDGQGATALHSAVNGVQLEAVKLLIE--ADSNKELLMMVTKKKATALHWAVEKQNLEI 565
               D  G TALH A     L+  K LI   A+ NK           TALH A     L+I
Sbjct: 2259 ---DNAGKTALHFAAQEAHLDVTKHLISEGAEVNKG-----DNAGKTALHSAPFSGQLDI 2310

Query: 564  VKFLVETDPDMEYCADVSGET---PLLMAMRQAQQGGNTSASAKI 439
             K+L+    D+    D  G T     L  +  A Q G+TS   K+
Sbjct: 2311 TKYLISQGADLNK-GDNDGLTLDQIYLTDIHLAIQDGHTSTVEKL 2354



 Score = 80.5 bits (197), Expect = 1e-12
 Identities = 104/443 (23%), Positives = 187/443 (42%), Gaps = 7/443 (1%)
 Frame = -1

Query: 1452 NNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEV---DNEGKNFLHIAAMFGVFKVVKYTL 1282
            N+GWT LH A++ G L    D+ ++      EV   DN+G+   H+AA  G   V KY +
Sbjct: 734  NDGWTALHIAAFSGHL----DVTKYLISQGAEVKKGDNDGRTAFHVAAQKGNTDVTKYLI 789

Query: 1281 EIKEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLL-YDPRVNKMTTNKEGKYVLDSIT 1105
                   + +N  D +G T +H  A +GH   T  L+     +NK     +G+  L    
Sbjct: 790  S----QGAEVNNGDIKGLTAIHSVAFSGHLDVTKYLISQGAEMNK--GGNDGRTAL---- 839

Query: 1104 FNYDMRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVLSKAVMENQLDCCKEI 925
                  +A  +G ++  +        +++    ++  D +  + L  A   + LD  K +
Sbjct: 840  -----HRAAFHGHLDVTK-------YLISHGAEVNKGDNHGTTALHSAASSDHLDVAKYL 887

Query: 924  YRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESGDVETIPNKK 745
              +  + +   +  G+ +LH AA  G L++ ++LIS G+                  NK 
Sbjct: 888  ISQ-GAEVNKGDKIGWTSLHIAAFEGFLDITKYLISQGSDL----------------NKG 930

Query: 744  FLTMVDGQGATALHSAVNGVQLEAVKLLI--EADSNKELLMMVTKKKATALHWAVEKQNL 571
            ++      G TALH A     L+  K LI   A+ NK           TAL+ A  K +L
Sbjct: 931  YI-----NGRTALHCAAVKNHLDVTKCLIIQGAEVNKG-----DNVGTTALNVAAHKGHL 980

Query: 570  EIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNTSASAKIRKFLLKTQPSQGKAPI 391
            ++  +++    ++    +  G TPL  A++        +    I K LL+      ++  
Sbjct: 981  DVTTYIISEGAEVNK-GNNDGRTPLHHAVQ--------NVHINIVKVLLE---GGARSDT 1028

Query: 390  GD-NRWTPLHYAAYKGDLNAIEDIIRYCPGCWEEVDNKKQNFLHIAVMFEHVKVVKFVLG 214
            GD +  TPL  + ++G   +I D+  +      ++D +    + +A+   H   ++ ++ 
Sbjct: 1029 GDIDGHTPLQMSTFQG-YQSIVDL--FIDRSNSKLDKRDLTDIQLAIQDGHTSTIEKLVS 1085

Query: 213  TKEVAATVLNGQDQDGKTPLHVA 145
                    +N Q  DG+T LH A
Sbjct: 1086 ----EGADINAQSTDGQTCLHRA 1104



 Score = 70.9 bits (172), Expect = 8e-10
 Identities = 71/289 (24%), Positives = 132/289 (45%), Gaps = 3/289 (1%)
 Frame = -1

Query: 963 AVMENQLDCCKEIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKE 784
           A M   LD  K +     +L+   N++ + ALH AAH   L++ ++LI            
Sbjct: 20  AAMYGDLDDTKHLIS-LGALVNKGNDDSWAALHSAAHESHLDIPKYLI-------RREAF 71

Query: 783 VESGDVETIPNKKFLTMVDGQGATALHSAVNGVQLEAVKLLIEADSNKELLMMVTKKKAT 604
           V  GD +++     +    GQ    ++    G ++    + +       ++        T
Sbjct: 72  VNKGDNDSLA-ALLMAAFSGQLDVTIYLISEGAEVNKGDIAVYLIYQGAVVNKGDISGRT 130

Query: 603 ALHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNTSASAKIRKFLL 424
           ALH A  + +L+I K+L+    ++    ++ GET    A+  A  GG+      + K+L+
Sbjct: 131 ALHSAAIRGHLDITKYLISQGAEVNN-GEIDGET----ALHFAAYGGHFD----VIKYLI 181

Query: 423 KTQPSQGKAPIGDNR---WTPLHYAAYKGDLNAIEDIIRYCPGCWEEVDNKKQNFLHIAV 253
               SQG A + +N+    T LH  A+ G L+  + +I       ++VDN ++  LH A 
Sbjct: 182 ----SQG-AVVNNNKNDGKTALHITAFHGHLDVTKYLISQGAEV-KKVDNDRRTALHCAA 235

Query: 252 MFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMTLCLL 106
             +H+++ K+++         +N    DG+T LH+AA  G+ ++T  L+
Sbjct: 236 QEDHLQITKYLIS----KGAEMNKGGNDGRTALHIAAQEGHLDVTKYLI 280



 Score = 66.2 bits (160), Expect = 2e-08
 Identities = 113/500 (22%), Positives = 191/500 (38%), Gaps = 17/500 (3%)
 Frame = -1

Query: 1455 GNNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEV---DNEGKNFLHIAAMFGVFKVVKYT 1285
            GN+G T LH A++ G L    D+ ++      EV   DN G   LH AA      V KY 
Sbjct: 832  GNDGRTALHRAAFHGHL----DVTKYLISHGAEVNKGDNHGTTALHSAASSDHLDVAKYL 887

Query: 1284 LEIKEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLLYDPR-VNKMTTNKEGKYVLDSI 1108
            +       + +NK D  G T LH+AA  G    T  L+     +NK   N        ++
Sbjct: 888  IS----QGAEVNKGDKIGWTSLHIAAFEGFLDITKYLISQGSDLNKGYINGRTALHCAAV 943

Query: 1107 TFNYDMRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVLSKAVMENQLDCCKE 928
              + D+ K  +    E V +GD                     + L+ A  +  LD    
Sbjct: 944  KNHLDVTKCLIIQGAE-VNKGDNV-----------------GTTALNVAAHKGHLDVTTY 985

Query: 927  IYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESGDVETIPNK 748
            I      +    NN+G   LHHA     +N+++ L+  GA++       ++GD++     
Sbjct: 986  IISEGAEV-NKGNNDGRTPLHHAVQNVHINIVKVLLEGGARS-------DTGDID----- 1032

Query: 747  KFLTMVDGQGATALHSAVNGVQLEAVKLLIEADSNKELLMMVTKKKATALHWAVEKQNLE 568
                     G T L  +        V L I+  ++K     + K+  T +  A++  +  
Sbjct: 1033 ---------GHTPLQMSTFQGYQSIVDLFIDRSNSK-----LDKRDLTDIQLAIQDGHTS 1078

Query: 567  IVKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNTSASAKIRKFLLKTQPSQGKAPIG 388
             ++ LV    D+       G+T L  A++   +   +               S     I 
Sbjct: 1079 TIEKLVSEGADIN-AQSTDGQTCLHRAIKLCYKSDKS------------MHDSDTLQEIS 1125

Query: 387  DNRWTPLHYAAYKGDLNAIEDIIRYCPGCWEEVDNKKQNFLHIAVMFEHVKVVK------ 226
            D           KG+L+  + ++ Y      ++D + +N  ++ + +   +VVK      
Sbjct: 1126 DE--------YCKGELSPEKALVFYLLENGAKLDVRDKNG-NLPIQYAKDEVVKQMILSR 1176

Query: 225  -FVLGTKEVAATVLN-GQD-----QDGKTPLHVAALSGNENMTLCLLYDPRVNKTTMSRE 67
             F  G + V   ++N G D      DG+ P H+AA  G    T  ++ +   N  T  ++
Sbjct: 1177 AFQYGEETVTENLINHGSDVEKATPDGQVPWHLAASFGRLKATKVII-NHGANMETGDKD 1235

Query: 66   GQSVLDSITFDYDKRKAGVY 7
            G S +        KRK+G Y
Sbjct: 1236 GYSAV-------YKRKSGQY 1248


>ref|XP_001649474.1| ankyrin 2,3/unc44 [Aedes aegypti] gi|108868779|gb|EAT33004.1|
            AAEL014742-PA, partial [Aedes aegypti]
          Length = 789

 Score =  130 bits (326), Expect = 1e-27
 Identities = 137/483 (28%), Positives = 219/483 (45%), Gaps = 20/483 (4%)
 Frame = -1

Query: 1452 NNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVDNEGKNFLHIAAMFGVFKVVKYTLEIK 1273
            N GWTPLH AS +G L  ++ +I     + +   NEG   LH A+  G  +VVK+ ++ +
Sbjct: 116  NGGWTPLHVASQNGHLEVVKLLIE-NRANVDTKKNEGWTPLHFASQNGHLEVVKFLIDNR 174

Query: 1272 EIDASVLNKQDNEGNTPLHVAALNGHESTTLCLLYDPRVNKMTTNKEGKYVLDSITFNYD 1093
               A+V   QD EG TPLHVA+ NGH    + LL + R N  T   EG   L   + N  
Sbjct: 175  ---ANVDTTQD-EGWTPLHVASQNGH-LEVVKLLIENRANVDTKKNEGWTPLHFASQN-- 227

Query: 1092 MRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVLSKAVMENQLDCCKEIYRRC 913
                   G +E V+        ++     +D+  +   + L  A     L+  K +    
Sbjct: 228  -------GHLEVVK-------FLIDNRANVDTTQDEGWTPLHLAAENGHLEVVKLLIENR 273

Query: 912  PSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKE--------VESGDVET- 760
             + + ++ N G+  LH A+  G L +++FLI   A       E         ++G +E  
Sbjct: 274  AN-VDTKKNGGWTPLHVASQNGHLEVVKFLIDNRANVDTTQYEGWTPLHVASQNGHLEVV 332

Query: 759  ---IPNKKFLTMVDGQGATALHSAVNGVQLEAVKLLIEADSNKELLMMVTK--------K 613
               I NK  +     +G T LH A     LE VKLLI+  +N   L++  +        K
Sbjct: 333  KLLIDNKANVDTTQNKGITPLHFASQNGHLEVVKLLIDNRANVVKLLIENRANVDTTQNK 392

Query: 612  KATALHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNTSASAKIRK 433
              T LH+A +  +LE+VK L+E   ++    +  G TPL  A R        +   ++ K
Sbjct: 393  GITPLHFASQNGHLEVVKLLIENRANVGTTQN-EGWTPLHFASR--------NGHLEVVK 443

Query: 432  FLLKTQPSQGKAPIGDNRWTPLHYAAYKGDLNAIEDIIRYCPGCWEEVDNKKQNFLHIAV 253
             L++ + +       +  WTPL+ A+  G L  ++ +I       +   N+    L++A 
Sbjct: 444  LLIENRANVDTTQ--NEGWTPLYVASINGHLEVVKLLINNRANV-DTTQNEGWTPLYVAS 500

Query: 252  MFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMTLCLLYDPRVNKTTMS 73
               H++VVK ++  K    T  N    +G TPLHVA+ +G+  + + LL D R N  T  
Sbjct: 501  KNGHLEVVKLLIDNKANVDTTQN----EGWTPLHVASQNGHLEV-VKLLIDNRANVDTTK 555

Query: 72   REG 64
             +G
Sbjct: 556  NKG 558



 Score =  122 bits (307), Expect = 2e-25
 Identities = 140/507 (27%), Positives = 223/507 (43%), Gaps = 44/507 (8%)
 Frame = -1

Query: 1452 NNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVDN---EGKNFLHIAAMFGVFKVVKYTL 1282
            N GWTPLH AS +G L    ++++F   +   VD    EG   LH+A+  G  +VVK  +
Sbjct: 281  NGGWTPLHVASQNGHL----EVVKFLIDNRANVDTTQYEGWTPLHVASQNGHLEVVKLLI 336

Query: 1281 EIKEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLLYDPRVNKMTTNKEGKYVLDSITF 1102
            + K    + ++   N+G TPLH A+ NGH      LL D R N +    E +  +D+   
Sbjct: 337  DNK----ANVDTTQNKGITPLHFASQNGHLEVVK-LLIDNRANVVKLLIENRANVDTT-- 389

Query: 1101 NYDMRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENND-SVLSKAVMENQLDCCKEI 925
                +  G+  +    Q G  E  +++  +       +N   + L  A     L+  K +
Sbjct: 390  ----QNKGITPLHFASQNGHLEVVKLLIENRANVGTTQNEGWTPLHFASRNGHLEVVKLL 445

Query: 924  YRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKE--------VESGD 769
                 ++  +QN EG+  L+ A+  G L +++ LI+  A       E         ++G 
Sbjct: 446  IENRANVDTTQN-EGWTPLYVASINGHLEVVKLLINNRANVDTTQNEGWTPLYVASKNGH 504

Query: 768  VET----IPNKKFLTMVDGQGATALHSAVNGVQLEAVKLLIEADSNKELLMMVTKKKA-T 604
            +E     I NK  +     +G T LH A     LE VKLLI+  +N +     TK K  T
Sbjct: 505  LEVVKLLIDNKANVDTTQNEGWTPLHVASQNGHLEVVKLLIDNRANVD----TTKNKGIT 560

Query: 603  ALHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNTSASAKI--RKF 430
             L+ A +  +LE+VK L++   +++   D  G TPL +A     Q G+      +   + 
Sbjct: 561  PLYVASKNGHLEVVKLLIDNKANVD-TTDNEGWTPLHVA----SQNGHLEVVKLLIENRA 615

Query: 429  LLKTQPSQGKAPIG---------------DNR----------WTPLHYAAYKGDLNAIED 325
             + T  ++G  P+                DNR          WTPLH A+  G L  ++ 
Sbjct: 616  NVDTTQNKGITPLHFASQNGHLEVVKLLIDNRANVDTTQNEGWTPLHVASQNGHLEVVKL 675

Query: 324  IIRYCPGCWEEVDNKKQNFLHIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVA 145
            +I       +   NK    LH A    H++VVK ++  +    T  N    +G TPLHVA
Sbjct: 676  LIENRANV-DTTQNKGITPLHFASQNGHLEVVKLLIDNRANVDTTQN----EGWTPLHVA 730

Query: 144  ALSGNENMTLCLLYDPRVNKTTMSREG 64
            + +G+  + + LL D R N  T   +G
Sbjct: 731  SQNGHLEV-VKLLIDNRANVDTTQNKG 756



 Score =  121 bits (304), Expect = 4e-25
 Identities = 136/507 (26%), Positives = 231/507 (45%), Gaps = 39/507 (7%)
 Frame = -1

Query: 1455 GNNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVDNEGKNFLHIAAMFGVFKVVKYTLEI 1276
            G+ GWTPLH A+ +G L  ++ +I     + +   +EG   LH+AA  G  +VVK  ++ 
Sbjct: 49   GDEGWTPLHLAAENGYLEVVKLLID-NGANVDTTQDEGWTPLHLAAENGHLEVVKLLID- 106

Query: 1275 KEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLLYDPRVNKMTTNKEG----------- 1129
               + + ++ + N G TPLHVA+ NGH    + LL + R N  T   EG           
Sbjct: 107  ---NRANVDTKKNGGWTPLHVASQNGH-LEVVKLLIENRANVDTKKNEGWTPLHFASQNG 162

Query: 1128 -----KYVLDSITFNYDMRKAGVYGVMERVQRGDKEYFRVVALD-VLLDSRDENNDSVLS 967
                 K+++D+       +  G   +    Q G  E  +++  +   +D++     + L 
Sbjct: 163  HLEVVKFLIDNRANVDTTQDEGWTPLHVASQNGHLEVVKLLIENRANVDTKKNEGWTPLH 222

Query: 966  KAVMENQLDCCKEIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKT----- 802
             A     L+  K +     ++  +Q +EG+  LH AA  G L +++ LI   A       
Sbjct: 223  FASQNGHLEVVKFLIDNRANVDTTQ-DEGWTPLHLAAENGHLEVVKLLIENRANVDTKKN 281

Query: 801  ---YHANKEVESGDVET----IPNKKFLTMVDGQGATALHSAVNGVQLEAVKLLIEADSN 643
                  +   ++G +E     I N+  +     +G T LH A     LE VKLLI+   N
Sbjct: 282  GGWTPLHVASQNGHLEVVKFLIDNRANVDTTQYEGWTPLHVASQNGHLEVVKLLID---N 338

Query: 642  KELLMMVTKKKATALHWAVEKQNLEIVKFLVETDPD-----MEYCADV-----SGETPLL 493
            K  +     K  T LH+A +  +LE+VK L++   +     +E  A+V      G TPL 
Sbjct: 339  KANVDTTQNKGITPLHFASQNGHLEVVKLLIDNRANVVKLLIENRANVDTTQNKGITPL- 397

Query: 492  MAMRQAQQGGNTSASAKIRKFLLKTQPSQGKAPIGDNRWTPLHYAAYKGDLNAIEDIIRY 313
                 A Q G+     ++ K L++ + + G     +  WTPLH+A+  G L  ++ +I  
Sbjct: 398  ---HFASQNGH----LEVVKLLIENRANVGTTQ--NEGWTPLHFASRNGHLEVVKLLIEN 448

Query: 312  CPGCWEEVDNKKQNFLHIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSG 133
                 +   N+    L++A +  H++VVK ++  +    T  N    +G TPL+VA+ +G
Sbjct: 449  RANV-DTTQNEGWTPLYVASINGHLEVVKLLINNRANVDTTQN----EGWTPLYVASKNG 503

Query: 132  NENMTLCLLYDPRVNKTTMSREGQSVL 52
            +  + + LL D + N  T   EG + L
Sbjct: 504  HLEV-VKLLIDNKANVDTTQNEGWTPL 529



 Score =  117 bits (294), Expect = 6e-24
 Identities = 138/496 (27%), Positives = 217/496 (43%), Gaps = 27/496 (5%)
 Frame = -1

Query: 1458 SGNNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVDNEGKNF---LHIAAMFGVFKVVKY 1288
            + N G TPLH AS +G L  ++ +I     +   VD EG      LH+AA  G  +VVK 
Sbjct: 15   ANNGGRTPLHVASQNGHLKVVKLLI----DNGANVDTEGDEGWTPLHLAAENGYLEVVKL 70

Query: 1287 TLEIKEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLLYDPRVNKMTTNKEGKYVLDSI 1108
             ++    + + ++   +EG TPLH+AA NGH    + LL D R N + T K G +     
Sbjct: 71   LID----NGANVDTTQDEGWTPLHLAAENGH-LEVVKLLIDNRAN-VDTKKNGGWT---- 120

Query: 1107 TFNYDMRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVLSKAVMENQLDCCKE 928
                 +  A   G +E V+        ++     +D++     + L  A     L+  K 
Sbjct: 121  ----PLHVASQNGHLEVVK-------LLIENRANVDTKKNEGWTPLHFASQNGHLEVVKF 169

Query: 927  IYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKE--------VESG 772
            +     ++  +Q +EG+  LH A+  G L +++ LI   A       E         ++G
Sbjct: 170  LIDNRANVDTTQ-DEGWTPLHVASQNGHLEVVKLLIENRANVDTKKNEGWTPLHFASQNG 228

Query: 771  DVET----IPNKKFLTMVDGQGATALHSAVNGVQLEAVKLLIEADSNKELLMMVTKKKA- 607
             +E     I N+  +     +G T LH A     LE VKLLIE  +N +     TKK   
Sbjct: 229  HLEVVKFLIDNRANVDTTQDEGWTPLHLAAENGHLEVVKLLIENRANVD-----TKKNGG 283

Query: 606  -TALHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNTSASAKIRKF 430
             T LH A +  +LE+VKFL++   +++      G TPL      A Q G+      +   
Sbjct: 284  WTPLHVASQNGHLEVVKFLIDNRANVD-TTQYEGWTPL----HVASQNGHLEVVKLLIDN 338

Query: 429  LLKTQPSQGKAPIGDNRWTPLHYAAYKGDLNAIE-------DIIRYCPGCWEEVD---NK 280
                  +Q K        TPLH+A+  G L  ++       ++++        VD   NK
Sbjct: 339  KANVDTTQNKG------ITPLHFASQNGHLEVVKLLIDNRANVVKLLIENRANVDTTQNK 392

Query: 279  KQNFLHIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMTLCLLYD 100
                LH A    H++VVK ++  +    T  N    +G TPLH A+ +G+  + + LL +
Sbjct: 393  GITPLHFASQNGHLEVVKLLIENRANVGTTQN----EGWTPLHFASRNGHLEV-VKLLIE 447

Query: 99   PRVNKTTMSREGQSVL 52
             R N  T   EG + L
Sbjct: 448  NRANVDTTQNEGWTPL 463



 Score =  112 bits (281), Expect = 2e-22
 Identities = 121/441 (27%), Positives = 198/441 (44%), Gaps = 2/441 (0%)
 Frame = -1

Query: 1362 EEVDNEGKNFLHIAAMFGVFKVVKYTLEIKEIDASVLNKQDNEGNTPLHVAALNGHESTT 1183
            +  +N G+  LH+A+  G  KVVK  ++    + + ++ + +EG TPLH+AA NG+    
Sbjct: 13   DTANNGGRTPLHVASQNGHLKVVKLLID----NGANVDTEGDEGWTPLHLAAENGY-LEV 67

Query: 1182 LCLLYDPRVNKMTTNKEGKYVLDSITFNYDMRKAGVYGVMERVQRGDKEYFRVVALDVLL 1003
            + LL D   N  TT  EG   L     N  +    +  +  R     K+      L V  
Sbjct: 68   VKLLIDNGANVDTTQDEGWTPLHLAAENGHLEVVKLL-IDNRANVDTKKNGGWTPLHV-- 124

Query: 1002 DSRDENNDSVLSKAVMENQLDCCKEIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFL 823
                +N    + K ++EN+ +            + ++ NEG+  LH A+  G L +++FL
Sbjct: 125  --ASQNGHLEVVKLLIENRAN------------VDTKKNEGWTPLHFASQNGHLEVVKFL 170

Query: 822  ISVGAKTYHANKEVESGDVETIPNKKFLTMVDGQGATALHSAVNGVQLEAVKLLIEADSN 643
            I                      N+  +     +G T LH A     LE VKLLIE  +N
Sbjct: 171  ID---------------------NRANVDTTQDEGWTPLHVASQNGHLEVVKLLIENRAN 209

Query: 642  KELLMMVTKKKA--TALHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQ 469
             +     TKK    T LH+A +  +LE+VKFL++   +++   D  G TPL +A   A+ 
Sbjct: 210  VD-----TKKNEGWTPLHFASQNGHLEVVKFLIDNRANVDTTQD-EGWTPLHLA---AEN 260

Query: 468  GGNTSASAKIRKFLLKTQPSQGKAPIGDNRWTPLHYAAYKGDLNAIEDIIRYCPGCWEEV 289
            G       ++ K L++ + +      G   WTPLH A+  G L  ++ +I       +  
Sbjct: 261  G-----HLEVVKLLIENRANVDTKKNGG--WTPLHVASQNGHLEVVKFLIDNRANV-DTT 312

Query: 288  DNKKQNFLHIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMTLCL 109
              +    LH+A    H++VVK ++  K    T  N     G TPLH A+ +G+  + + L
Sbjct: 313  QYEGWTPLHVASQNGHLEVVKLLIDNKANVDTTQN----KGITPLHFASQNGHLEV-VKL 367

Query: 108  LYDPRVNKTTMSREGQSVLDS 46
            L D R N   +  E ++ +D+
Sbjct: 368  LIDNRANVVKLLIENRANVDT 388



 Score = 84.7 bits (208), Expect = 6e-14
 Identities = 92/322 (28%), Positives = 140/322 (43%)
 Frame = -1

Query: 1452 NNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVDNEGKNFLHIAAMFGVFKVVKYTLEIK 1273
            N GWTPLH AS +G L  ++ +I     + +   N+G   L++A+  G  +VVK  ++ K
Sbjct: 523  NEGWTPLHVASQNGHLEVVKLLIDN-RANVDTTKNKGITPLYVASKNGHLEVVKLLIDNK 581

Query: 1272 EIDASVLNKQDNEGNTPLHVAALNGHESTTLCLLYDPRVNKMTTNKEGKYVLDSITFNYD 1093
                + ++  DNEG TPLHVA+ NGH    + LL + R N  TT  +G   L   + N  
Sbjct: 582  ----ANVDTTDNEGWTPLHVASQNGH-LEVVKLLIENRANVDTTQNKGITPLHFASQN-- 634

Query: 1092 MRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVLSKAVMENQLDCCKEIYRRC 913
                   G +E V+             +L+D+R  N D+                     
Sbjct: 635  -------GHLEVVK-------------LLIDNR-ANVDTT-------------------- 653

Query: 912  PSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESGDVETIPNKKFLTM 733
                    NEG+  LH A+  G L +++ LI                +V+T  NK     
Sbjct: 654  -------QNEGWTPLHVASQNGHLEVVKLLIE------------NRANVDTTQNK----- 689

Query: 732  VDGQGATALHSAVNGVQLEAVKLLIEADSNKELLMMVTKKKATALHWAVEKQNLEIVKFL 553
                G T LH A     LE VKLLI+  +N +       +  T LH A +  +LE+VK L
Sbjct: 690  ----GITPLHFASQNGHLEVVKLLIDNRANVD---TTQNEGWTPLHVASQNGHLEVVKLL 742

Query: 552  VETDPDMEYCADVSGETPLLMA 487
            ++   +++   +  G TPL +A
Sbjct: 743  IDNRANVDTTQN-KGITPLYVA 763


>ref|XP_001181547.2| PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin
            repeat subunit B-like, partial [Strongylocentrotus
            purpuratus]
          Length = 1362

 Score =  129 bits (323), Expect = 3e-27
 Identities = 152/488 (31%), Positives = 217/488 (44%), Gaps = 47/488 (9%)
 Frame = -1

Query: 1452 NNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEV---DNEGKNFLHIAAMFGVFKVVKYTL 1282
            N+ WT LH A+ +G L    D+I++      +V   DN+G+  LHI +  G   V KY +
Sbjct: 728  NDDWTALHSAAQEGHL----DVIKYLISEEADVNKGDNDGRTALHIVSQKGHLDVTKYLI 783

Query: 1281 EIKEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLL-YDPRVNKMTTNKEGKYVLDSIT 1105
                 D + ++K D+ G T LH AAL+GH      L+  +  VNK   +K+G   L    
Sbjct: 784  SHGG-DGADVSKGDDGGKTALHKAALSGHLDVIKYLISQEADVNK--GDKDGATALHEAA 840

Query: 1104 FNYDMRKAGVYGVMERV--QRGDKEYFRVVALDVLLDSRDENNDSVLSKAVMENQLDCCK 931
            FN  +       VM+ +    GD         DV+    D+   + L  A +   LD  K
Sbjct: 841  FNCHL------DVMKYLISHGGD-------GADVI--KGDDGGKTALHIATLSGHLDAIK 885

Query: 930  EIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESG------- 772
             +  +   +    +NEG  ALH AA +G L+++++LISV A     NK +  G       
Sbjct: 886  YLISQGADV-NKGDNEGGTALHIAAQKGHLDVIKYLISVEADV---NKGINEGWTALHIA 941

Query: 771  --------DVETIPNKKFLTMVDGQGATALHSAVNGVQLEAVKLLI--EADSNKE----L 634
                     +  I     +   D  G TALHSA +   L+ +K LI  EAD NK      
Sbjct: 942  VFNGHLDVTIYLISQGADVNEGDINGRTALHSAAHEGHLDVIKYLISEEADVNKGDNGGR 1001

Query: 633  LMMVTK--------------KKATALHWAVEKQNLEIVKFLVETDPDMEYCADV-SGETP 499
             + VTK                 TALH A    +L+++K+L+    D    ADV  G+  
Sbjct: 1002 TLDVTKYLISQGADVNKGANDGRTALHDAAFNCHLDVMKYLISHGGDG---ADVIKGDDG 1058

Query: 498  LLMAMRQAQQGGNTSASAKIRKFLLKTQPSQGKAPIGDNRW-TPLHYAAYKGDLNAIE-D 325
               A+  A   G+  A     K+L+       K   GDN   T LH AA KG L+    D
Sbjct: 1059 GKTALHIATLSGHLDAI----KYLISQGADVNK---GDNEGGTALHIAAQKGHLDEGHLD 1111

Query: 324  IIRYCPGCWEEV---DNKKQNFLHIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPL 154
            +I+Y      +V   DN  +  LHIA    H+ V K+++      A V  G D DGKT L
Sbjct: 1112 VIKYLISQEADVNEGDNNGRTALHIASQKGHLDVTKYLISHGGDGADVSKG-DNDGKTAL 1170

Query: 153  HVAALSGN 130
            H AALSG+
Sbjct: 1171 HKAALSGH 1178



 Score =  112 bits (280), Expect = 3e-22
 Identities = 130/485 (26%), Positives = 217/485 (44%), Gaps = 36/485 (7%)
 Frame = -1

Query: 1452 NNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEV---DNEGKNFLHIAAMFGVFKVVKYTL 1282
            N G T LH A++ G +    D+I++      +V   DN  +  LH AA      V+KY +
Sbjct: 131  NEGATALHMAAFSGHI----DVIKYLMSQGADVNKGDNYDRTALHYAAASDHLDVIKYLI 186

Query: 1281 EIKEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLLYDPR-VNKMTTNKEGKYVLDSIT 1105
                   + +NK +N+  T LH AA NGH   T+ L+     VNK   +  G   L    
Sbjct: 187  T----QEAEVNKGENDCKTALHEAAFNGHLDVTIYLISQGADVNK--GDNTGATALHKAA 240

Query: 1104 FN--YDMRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENND--SVLSKAVMENQLDC 937
            F+   D+ K  +    + V +GD      +    + +    +ND  + L +A     LD 
Sbjct: 241  FSGHIDVIKYLISQGAD-VNKGDNYDRTALHYAAVTEVNKGDNDCMTALHEAAFNGHLDV 299

Query: 936  CKEIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESGDVE-T 760
               +  +   +    +NEG  ALH AA  G L+++++LIS GA     + E     ++  
Sbjct: 300  TIYLITQGADV-NKGDNEGATALHKAAFSGHLDVIKYLISQGADVNKGDNEGHLDVIKYL 358

Query: 759  IPNKKFLTMVDGQGATALHSAVNGVQLEAVKLLI--EADSNKELLMM------------- 625
            I  +  +   D  G+TALH A     L+ +K LI  EA+ NK  L +             
Sbjct: 359  ISQEADVNKGDSDGSTALHMASLNGCLDVIKYLISKEAEVNKGHLDVTKYLISHGGDGAD 418

Query: 624  ---VTKKKATALHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNTS 454
               V  +  TALH A    +L+++K+L+  + D+       G+   L A+  A   G+  
Sbjct: 419  VNKVDNEGMTALHLAALMCHLDVIKYLISKEADVN-----KGDNHGLTALHMAAFNGHLD 473

Query: 453  ASAKIRKFLLKTQPSQGKAPIGDNRWTPLHYAAYKGDLNAIEDIIRYCPGCWEEVDNKKQ 274
                + K+L+  +    K  + D R T LH AA+ G L+ ++ +I       EE D  K 
Sbjct: 474  ----VIKYLISEEADVNKV-VNDGR-TALHSAAFNGHLDVMKYLIS------EEADVHKG 521

Query: 273  N-----FLHIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAA----LSGNENM 121
            N      LH A    H+ V+K+++       + +N ++ +G T L++AA     +G+ ++
Sbjct: 522  NNDGRTVLHSAASNGHLDVIKYLI----CLDSDVNKENNEGGTALNIAAQKAVFNGHLDV 577

Query: 120  TLCLL 106
            T+ L+
Sbjct: 578  TIYLI 582



 Score =  104 bits (259), Expect = 7e-20
 Identities = 120/449 (26%), Positives = 185/449 (41%), Gaps = 9/449 (2%)
 Frame = -1

Query: 1449 NGWTPLHHASYDGDLSAIEDIIRFCPGSWEEV--DNEGKNFLHIAAMFGVFKVVKYTLEI 1276
            +G T LH A+++  L  ++ +I       + +  D+ GK  LHIA + G    +KY +  
Sbjct: 831  DGATALHEAAFNCHLDVMKYLISHGGDGADVIKGDDGGKTALHIATLSGHLDAIKYLIS- 889

Query: 1275 KEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLL-YDPRVNKMTTNKEGKYVLDSITFN 1099
                 + +NK DNEG T LH+AA  GH      L+  +  VNK     EG   L    FN
Sbjct: 890  ---QGADVNKGDNEGGTALHIAAQKGHLDVIKYLISVEADVNKGI--NEGWTALHIAVFN 944

Query: 1098 YDMRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVLSKAVMENQLDCCKEIYR 919
              +                      V + ++    D N   +                  
Sbjct: 945  GHLD---------------------VTIYLISQGADVNEGDI------------------ 965

Query: 918  RCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESGDVE--TIPNKK 745
                        G  ALH AAH G L+++++LIS  A     +    + DV    I    
Sbjct: 966  -----------NGRTALHSAAHEGHLDVIKYLISEEADVNKGDNGGRTLDVTKYLISQGA 1014

Query: 744  FLTMVDGQGATALHSAVNGVQLEAVKLLIEADSNKELLMMVTKKKATALHWAVEKQNLEI 565
             +      G TALH A     L+ +K LI    +   ++       TALH A    +L+ 
Sbjct: 1015 DVNKGANDGRTALHDAAFNCHLDVMKYLISHGGDGADVIKGDDGGKTALHIATLSGHLDA 1074

Query: 564  VKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNTSASAKIRKFLLKTQPSQGKAPIGD 385
            +K+L+    D+    D  G T L +A   AQ+G        + K+L+  +    +   GD
Sbjct: 1075 IKYLISQGADVNK-GDNEGGTALHIA---AQKGHLDEGHLDVIKYLISQEADVNE---GD 1127

Query: 384  NRW-TPLHYAAYKGDLNAIEDIIRYCPGCWEEV---DNKKQNFLHIAVMFEHVKVVKFVL 217
            N   T LH A+ KG L+  + +I +  G   +V   DN  +  LH A +  H+ V+K+++
Sbjct: 1128 NNGRTALHIASQKGHLDVTKYLISH-GGDGADVSKGDNDGKTALHKAALSGHLAVIKYLI 1186

Query: 216  GTKEVAATVLNGQDQDGKTPLHVAALSGN 130
                  A V  G + DG+T LH AA SG+
Sbjct: 1187 SQ---GADVNKGAN-DGRTALHDAAFSGH 1211



 Score =  103 bits (258), Expect = 9e-20
 Identities = 135/488 (27%), Positives = 212/488 (43%), Gaps = 32/488 (6%)
 Frame = -1

Query: 1452 NNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVDNEG----KNFLHIAAMFGVFKVVKYT 1285
            N G T L+ A+     +   D+  +      +V NEG    +  LH+AA  G   V+KY 
Sbjct: 556  NEGGTALNIAAQKAVFNGHLDVTIYLISQGADV-NEGDIHCRTALHLAAQEGHLDVMKYL 614

Query: 1284 LEIKEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLLYDPRVNKMTTNKEGKYVLDSIT 1105
            +  +E D   +NK DN+G T +H+A+  GH   T                  KY++    
Sbjct: 615  IS-EEAD---VNKGDNDGRTVIHIASQKGHLDVT------------------KYLISHGG 652

Query: 1104 FNYDMRKA---GVYGVMERVQRGDKEYFRVVALDVLLDSRDENND-SVLSKAVMENQLDC 937
               D+ K    G   + +    G  +  + +  +    ++ +N+D + L  A  E  LD 
Sbjct: 653  DGADVGKGDNDGATALHKAAHEGHLDVIKYLISEESDVNKGDNDDWTALHSASQEGHLDV 712

Query: 936  CKEIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESGDVETI 757
             K +     + +   +N+ + ALH AA  G L+++++LIS  A     + +  +  +  +
Sbjct: 713  IKYLISE-EADVNKGDNDDWTALHSAAQEGHLDVIKYLISEEADVNKGDNDGRTA-LHIV 770

Query: 756  PNK------KFLTMVDGQGA----------TALHSAVNGVQLEAVKLLI--EADSNKELL 631
              K      K+L    G GA          TALH A     L+ +K LI  EAD NK   
Sbjct: 771  SQKGHLDVTKYLISHGGDGADVSKGDDGGKTALHKAALSGHLDVIKYLISQEADVNKG-- 828

Query: 630  MMVTKKKATALHWAVEKQNLEIVKFLVETDPDMEYCADV-SGETPLLMAMRQAQQGGNTS 454
                K  ATALH A    +L+++K+L+    D    ADV  G+     A+  A   G+  
Sbjct: 829  ---DKDGATALHEAAFNCHLDVMKYLISHGGD---GADVIKGDDGGKTALHIATLSGHLD 882

Query: 453  ASAKIRKFLLKTQPSQGKAPIGDNR-WTPLHYAAYKGDLNAIEDIIRYCPGCWEEVD--- 286
            A     K+L+       K   GDN   T LH AA KG L    D+I+Y      +V+   
Sbjct: 883  AI----KYLISQGADVNK---GDNEGGTALHIAAQKGHL----DVIKYLISVEADVNKGI 931

Query: 285  NKKQNFLHIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMTLCLL 106
            N+    LHIAV   H+ V  +++         +N  D +G+T LH AA  G+ ++   L+
Sbjct: 932  NEGWTALHIAVFNGHLDVTIYLIS----QGADVNEGDINGRTALHSAAHEGHLDVIKYLI 987

Query: 105  YDPR-VNK 85
             +   VNK
Sbjct: 988  SEEADVNK 995



 Score = 72.4 bits (176), Expect = 3e-10
 Identities = 115/501 (22%), Positives = 194/501 (38%), Gaps = 63/501 (12%)
 Frame = -1

Query: 1347 EGKNFLHIAAMFGVFKVVKYTLEIKEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLLY 1168
            +GK  LH         V++Y +       + + K DN+G T L+ AA +GH   T  L+ 
Sbjct: 24   DGKARLHNTVNKHHRTVIEYPIT----QGAEIEKGDNDGWTALNSAAFDGHLDVTKSLI- 78

Query: 1167 DPRVNKMTTNKEGKYVLDSITFNYDMRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDE 988
                 +   NK       +   NYD  +  +Y           +Y      DV  +  D 
Sbjct: 79   ---SQRADVNKGDNTADVNKGDNYD--RTALYYAAVSDHLDVIKYLISQGADV--NKGDN 131

Query: 987  NNDSVLSKAVMENQLDCCKEIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGA 808
               + L  A     +D  K +  +   +    N +   ALH+AA    L+++++LI+  A
Sbjct: 132  EGATALHMAAFSGHIDVIKYLMSQGADVNKGDNYD-RTALHYAAASDHLDVIKYLITQEA 190

Query: 807  KTYHANKEVESGDVETIPNKKFLTMV------------DGQGATALHSAVNGVQLEAVKL 664
            +      + ++   E   N      +            D  GATALH A     ++ +K 
Sbjct: 191  EVNKGENDCKTALHEAAFNGHLDVTIYLISQGADVNKGDNTGATALHKAAFSGHIDVIKY 250

Query: 663  LIE--ADSNK-----------ELLMMVTKKK---ATALHWAVEKQNLEIVKFLVETDPDM 532
            LI   AD NK             +  V K      TALH A    +L++  +L+    D+
Sbjct: 251  LISQGADVNKGDNYDRTALHYAAVTEVNKGDNDCMTALHEAAFNGHLDVTIYLITQGADV 310

Query: 531  EYCADVSGETPL--------------LMAMRQAQQGGNTSASAKIRKFLLKTQPSQGKAP 394
                D  G T L              L++       G+      + K+L+  +    K  
Sbjct: 311  NK-GDNEGATALHKAAFSGHLDVIKYLISQGADVNKGDNEGHLDVIKYLISQEADVNKGD 369

Query: 393  IGDNRWTPLHYAAYKGDLNAIE--------------DIIRYC------PGCWEEVDNKKQ 274
               +  T LH A+  G L+ I+              D+ +Y            +VDN+  
Sbjct: 370  SDGS--TALHMASLNGCLDVIKYLISKEAEVNKGHLDVTKYLISHGGDGADVNKVDNEGM 427

Query: 273  NFLHIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMTLCLLYDPR 94
              LH+A +  H+ V+K+++ +KE     +N  D  G T LH+AA +G+ ++   L+ +  
Sbjct: 428  TALHLAALMCHLDVIKYLI-SKEAD---VNKGDNHGLTALHMAAFNGHLDVIKYLISEEA 483

Query: 93   -VNKTTMSREGQSVLDSITFD 34
             VNK     +G++ L S  F+
Sbjct: 484  DVNKVV--NDGRTALHSAAFN 502


>ref|XP_003729085.1| PREDICTED: uncharacterized protein LOC752844 [Strongylocentrotus
            purpuratus]
          Length = 1556

 Score =  128 bits (322), Expect = 3e-27
 Identities = 133/493 (26%), Positives = 215/493 (43%), Gaps = 20/493 (4%)
 Frame = -1

Query: 1452 NNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVDNEGKNFLHIAAMFGVFKVVKYTLEIK 1273
            N+ +T LH A++ G L   + +I         V N+G+  LH+AA  G   V KY +   
Sbjct: 39   NDSFTALHLAAFSGHLDVTKYLISQAADMNNGV-NDGRTALHLAAQVGHLDVTKYLIS-- 95

Query: 1272 EIDASVLNKQDNEGNTPLHVAALNGHESTTLCLLYDPRVNKMTTNKEGKYVLDSITFNYD 1093
                + +NK+D +G T LH AA NGH   T  LL          N+ G    +S     +
Sbjct: 96   --QGAEVNKEDKDGETALHQAAFNGHLDVTKYLL----------NQGGDVKKES-----N 138

Query: 1092 MRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVLSKAVMENQLDCCKEIYRRC 913
            + +  ++G  +       +Y  ++   V ++S   N  + L  A     LD  K +  + 
Sbjct: 139  IGRTALHGASQNGHLDVTKY--LINQGVDMNSGVNNGRTALHLAAQVGHLDVTKYLLSQ- 195

Query: 912  PSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESG--------DVETI 757
             + +   +N+ + ALH AA  G L++ ++LIS GA+    NKEV  G         V  +
Sbjct: 196  GAEVNEGDNDSFTALHLAAFNGHLDVTKYLISHGAR---INKEVNDGRTALHLAAQVGHL 252

Query: 756  PNKKFLTMVD-------GQGATALHSAVNGVQLEAVKLLIE--ADSNKELLMMVTKKKAT 604
               K+L             G TALH A     L+    L+   A+ NKE         +T
Sbjct: 253  DVTKYLISQGADLNNGVNDGRTALHLAAQVGHLDVTNYLLSQGAEVNKE-----GNDGST 307

Query: 603  ALHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNTSASAKIRKFLL 424
            ALH A +  +L+I+K+L+    D+   ++       + A+  A   G+      + K+L 
Sbjct: 308  ALHLAAQNGHLDIIKYLLSQGADVNKQSNDG-----ITALHHAAFNGHLD----VIKYLT 358

Query: 423  KTQPSQGKAPIGDNRWTPLHYAAYKGDLNAIEDIIRYCPGCWEEVDNKKQN---FLHIAV 253
                   K    +N  T LH AA+ G L    D+I+Y      +V+ +  N    LH+A 
Sbjct: 359  SQGGDVNKQ--SNNGLTTLHVAAFSGHL----DVIKYLTSQGGDVNKQSNNGLTTLHVAA 412

Query: 252  MFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMTLCLLYDPRVNKTTMS 73
               H+ V K++L         +N +D DG+T LH+AA +G+ ++T   L+    N    S
Sbjct: 413  REGHLDVTKYLLS----QGAEVNKEDNDGETALHLAAFNGHLDVTK-YLFSQGANMNKQS 467

Query: 72   REGQSVLDSITFD 34
             +G + L     D
Sbjct: 468  NDGLTALHLAAHD 480



 Score =  113 bits (283), Expect = 1e-22
 Identities = 136/482 (28%), Positives = 206/482 (42%), Gaps = 33/482 (6%)
 Frame = -1

Query: 1452 NNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVDNEGKNFLHIAAMFGVFKVVKYTLEIK 1273
            N G T LH AS +G L   + +I         V+N G+  LH+AA  G   V KY L   
Sbjct: 138  NIGRTALHGASQNGHLDVTKYLINQGVDMNSGVNN-GRTALHLAAQVGHLDVTKYLLS-- 194

Query: 1272 EIDASVLNKQDNEGNTPLHVAALNGHESTTLCLL-YDPRVNKMTTNKEGKYVLDSITFNY 1096
                + +N+ DN+  T LH+AA NGH   T  L+ +  R+NK   +      L +   + 
Sbjct: 195  --QGAEVNEGDNDSFTALHLAAFNGHLDVTKYLISHGARINKEVNDGRTALHLAAQVGHL 252

Query: 1095 DMRK------AGVYGVMERVQRGDKEYFRVVALDVL-------LDSRDENND--SVLSKA 961
            D+ K      A +   +   +       +V  LDV         +   E ND  + L  A
Sbjct: 253  DVTKYLISQGADLNNGVNDGRTALHLAAQVGHLDVTNYLLSQGAEVNKEGNDGSTALHLA 312

Query: 960  VMENQLDCCKEIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKE- 784
                 LD  K +  +   +   Q+N+G  ALHHAA  G L+++++L S G      +   
Sbjct: 313  AQNGHLDIIKYLLSQGADV-NKQSNDGITALHHAAFNGHLDVIKYLTSQGGDVNKQSNNG 371

Query: 783  -------VESGDVETIPNKKFLTMVDG-------QGATALHSAVNGVQLEAVKLLIE--A 652
                     SG ++ I   K+LT   G        G T LH A     L+  K L+   A
Sbjct: 372  LTTLHVAAFSGHLDVI---KYLTSQGGDVNKQSNNGLTTLHVAAREGHLDVTKYLLSQGA 428

Query: 651  DSNKELLMMVTKKKATALHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQ 472
            + NKE          TALH A    +L++ K+L     +M   ++       L A+  A 
Sbjct: 429  EVNKE-----DNDGETALHLAAFNGHLDVTKYLFSQGANMNKQSNDG-----LTALHLAA 478

Query: 471  QGGNTSASAKIRKFLLKTQPSQGKAPIGDNRWTPLHYAAYKGDLNAIEDIIRYCPGCWEE 292
              G+      + K+L     SQG    GD        AA+ G L+  + IIR+  G    
Sbjct: 479  HDGHLD----VTKYL----QSQG----GD-------VAAFSGHLDVTKYIIRHGVGMNNG 519

Query: 291  VDNKKQNFLHIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMTLC 112
            V N  +  LH+A    H+ V K+++         +N +D+DG+T LH AA +G+ ++T  
Sbjct: 520  V-NDGETALHLAAQVGHLDVTKYLIS----QGAEVNKEDKDGETALHQAAFNGHLDVTKY 574

Query: 111  LL 106
            LL
Sbjct: 575  LL 576



 Score =  105 bits (261), Expect = 4e-20
 Identities = 120/425 (28%), Positives = 184/425 (43%), Gaps = 12/425 (2%)
 Frame = -1

Query: 1455 GNNGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVD---NEGKNFLHIAAMFGVFKVVKYT 1285
            GN+G T LH A+ +G L    DII++      +V+   N+G   LH AA  G   V+KY 
Sbjct: 302  GNDGSTALHLAAQNGHL----DIIKYLLSQGADVNKQSNDGITALHHAAFNGHLDVIKYL 357

Query: 1284 LEIKEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLLYDPR-VNKMTTNKEGKYVLDSI 1108
                      +NKQ N G T LHVAA +GH      L      VNK + N         +
Sbjct: 358  TS----QGGDVNKQSNNGLTTLHVAAFSGHLDVIKYLTSQGGDVNKQSNN--------GL 405

Query: 1107 TFNYDMRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVLSKAVMENQLDCCKE 928
            T  +   + G   V + +     E          ++  D + ++ L  A     LD  K 
Sbjct: 406  TTLHVAAREGHLDVTKYLLSQGAE----------VNKEDNDGETALHLAAFNGHLDVTKY 455

Query: 927  IYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESGDVETIPNK 748
            ++ +  ++   Q+N+G  ALH AAH G L++ ++L S G      +  +   DV     +
Sbjct: 456  LFSQGANM-NKQSNDGLTALHLAAHDGHLDVTKYLQSQGGDVAAFSGHL---DVTKYIIR 511

Query: 747  KFLTMVDG--QGATALHSAVNGVQLEAVKLLIE--ADSNKELLMMVTKKKATALHWAVEK 580
              + M +G   G TALH A     L+  K LI   A+ NKE      K   TALH A   
Sbjct: 512  HGVGMNNGVNDGETALHLAAQVGHLDVTKYLISQGAEVNKE-----DKDGETALHQAAFN 566

Query: 579  QNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNTSASAKIRKFLLKTQPSQGK 400
             +L++ K+L+    D++  +++        A+  A Q G+      + K+L+        
Sbjct: 567  GHLDVTKYLLSQGGDVKNESNIG-----FTALHGASQNGHLD----VTKYLINQGVDMNS 617

Query: 399  APIGDNRWTPLHYAAYKGDLNAIEDIIRYCPGCWEEVDNKKQN----FLHIAVMFEHVKV 232
                +N  T LH AA  G L    D+ +Y      EV NK+ N     LH+A    H+ V
Sbjct: 618  GV--NNGRTALHLAAQVGHL----DVTKYLLSQGAEV-NKESNDSFTALHLAAFKGHLDV 670

Query: 231  VKFVL 217
             K+++
Sbjct: 671  TKYLI 675



 Score = 85.9 bits (211), Expect = 3e-14
 Identities = 114/469 (24%), Positives = 195/469 (41%), Gaps = 62/469 (13%)
 Frame = -1

Query: 1254 LNKQDNEGNTPLHVAALNGH-ESTTLCLLYDPRVNKMTTNKEGKYVLDSITFNYDMRK-- 1084
            ++K + +G TPLH+AA  G  ++T   +     VNK + +      L + + + D+ K  
Sbjct: 1    MDKTNPDGQTPLHLAASLGRLKATKYLISQGAEVNKQSNDSFTALHLAAFSGHLDVTKYL 60

Query: 1083 ------------AGVYGVMERVQRGDKEYFR-VVALDVLLDSRDENNDSVLSKAVMENQL 943
                         G   +    Q G  +  + +++    ++  D++ ++ L +A     L
Sbjct: 61   ISQAADMNNGVNDGRTALHLAAQVGHLDVTKYLISQGAEVNKEDKDGETALHQAAFNGHL 120

Query: 942  DCCKEIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESG--- 772
            D  K +  +    +  ++N G  ALH A+  G L++ ++LI+ G      N  V +G   
Sbjct: 121  DVTKYLLNQGGD-VKKESNIGRTALHGASQNGHLDVTKYLINQGV---DMNSGVNNGRTA 176

Query: 771  -----DVETIPNKKFLTMV-------DGQGATALHSAVNGVQLEAVKLLIE--ADSNKEL 634
                  V  +   K+L          D    TALH A     L+  K LI   A  NKE+
Sbjct: 177  LHLAAQVGHLDVTKYLLSQGAEVNEGDNDSFTALHLAAFNGHLDVTKYLISHGARINKEV 236

Query: 633  LMMVTKKKATALHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMR--------- 481
                     TALH A +  +L++ K+L+    D+    +  G T L +A +         
Sbjct: 237  -----NDGRTALHLAAQVGHLDVTKYLISQGADLNNGVN-DGRTALHLAAQVGHLDVTNY 290

Query: 480  ------QAQQGGNTSASA----------KIRKFLLKTQPSQGKAPIGDNRWTPLHYAAYK 349
                  +  + GN  ++A           I K+LL       K    ++  T LH+AA+ 
Sbjct: 291  LLSQGAEVNKEGNDGSTALHLAAQNGHLDIIKYLLSQGADVNKQ--SNDGITALHHAAFN 348

Query: 348  GDLNAIEDIIRYCPGCWEEVDNKKQN---FLHIAVMFEHVKVVKFVLGTKEVAATVLNGQ 178
            G L    D+I+Y      +V+ +  N    LH+A    H+ V+K++          +N Q
Sbjct: 349  GHL----DVIKYLTSQGGDVNKQSNNGLTTLHVAAFSGHLDVIKYLTS----QGGDVNKQ 400

Query: 177  DQDGKTPLHVAALSGNENMTLCLL-YDPRVNKTTMSREGQSVLDSITFD 34
              +G T LHVAA  G+ ++T  LL     VNK     +G++ L    F+
Sbjct: 401  SNNGLTTLHVAAREGHLDVTKYLLSQGAEVNKE--DNDGETALHLAAFN 447


>ref|XP_001183008.2| PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin
            repeat subunit A-like [Strongylocentrotus purpuratus]
          Length = 1275

 Score =  125 bits (314), Expect = 3e-26
 Identities = 138/494 (27%), Positives = 216/494 (43%), Gaps = 46/494 (9%)
 Frame = -1

Query: 1449 NGWTPLHHASYDGDLSAIEDIIRFCPGSWEEVD---NEGKNFLHIAAMFGVFKVVKYTLE 1279
            +G T LH A++ G L    D+ ++      EV+   + G+  LH AA  G  ++ KY + 
Sbjct: 474  DGSTALHIAAFGGHL----DVTKYLISQGAEVNKGNDGGRTALHRAAFSGHLEIAKYLIS 529

Query: 1278 IKEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLL-YDPRVNKMTTNKEGKYVLDSITF 1102
                  +  NK+DN G+T LH AA+NGH   T  L+     VNK   +K+G+ VL S TF
Sbjct: 530  ----QGAEANKEDNYGSTALHSAAVNGHYDVTKYLISQGAEVNK--GDKDGRTVLHSATF 583

Query: 1101 --NYDMRKAGVYGVMERVQ--RGDKE------------------YFRVVALDVLLDSRDE 988
              + D+ K   Y + +  +  +GDK+                  YF     DV  +  D 
Sbjct: 584  GGHLDVTK---YLISQEAEGNKGDKDGKTALHLAAIKGHLDITKYFISQGADV--NKGDN 638

Query: 987  NNDSVLSKAVMENQLDCCKEIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGA 808
                 L  A      D  K +  +  + +  +NN G  ALH AA+ G  ++ ++LI  GA
Sbjct: 639  YGSIALHSAAANGHYDVTKYLISQ-GAEVNEENNRGVTALHKAAYNGHCDVTKYLICQGA 697

Query: 807  KTYHA--------NKEVESGDVET----IPNKKFLTMVDGQGATALHSAVNGVQLEAVKL 664
            +            +K   +G ++     I     +   D  G++ALHSA      +  K 
Sbjct: 698  EVNEGDNDGSSALHKAAHNGHLDVTECLISQGAEVNKGDNYGSSALHSAAVNGHYDVTKY 757

Query: 663  LIEADSNKELLMMVTKKKATALHWAV-----EKQNLEIVKFLVETDPDMEYCADVSGETP 499
            LI   S  + +     +  TALH A      +K +L I ++LV    ++       G   
Sbjct: 758  LI---SQGDEVNKANNEGRTALHSATFEGHFDKGHLAITEYLVSQGAEVN-----MGNNA 809

Query: 498  LLMAMRQAQQGGNTSASAKIRKFLLKTQPSQGKAPIGDNRWTPLHYAAYKGDLNAIEDII 319
               A+  A  GG++     + K+L+       K   G    T LH AA KG L+  E +I
Sbjct: 810  GWTALHSAAFGGHSD----VTKYLISQGAEVNKGEKGGK--TALHLAANKGHLDITEHLI 863

Query: 318  RYCPGCWEEVDNKKQN---FLHIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHV 148
                    EV+   +N    LH A    H+ V K+++   +     LN +D DG+T LH 
Sbjct: 864  SQ----GAEVNKGDKNGGTALHSAARSGHLVVTKYLISQGD----DLNKEDNDGRTALHS 915

Query: 147  AALSGNENMTLCLL 106
            AA+SG+ ++T CL+
Sbjct: 916  AAVSGHLDVTKCLI 929



 Score =  124 bits (311), Expect = 6e-26
 Identities = 148/504 (29%), Positives = 227/504 (45%), Gaps = 33/504 (6%)
 Frame = -1

Query: 1449 NGWTPLHHASYDGDLSAIEDIIRFCPGSWEEV---DNEGKNFLHIAAMFGVFKVVKYTL- 1282
            NG T LH A++ G L    D+ ++  G   EV   D++G   LH A + G   V KY   
Sbjct: 27   NGSTALHTAAFRGHL----DVTKYLIGQRAEVNKGDDDGMTALHSAVVGGHLDVTKYLTS 82

Query: 1281 ---EIKEIDASV-LNKQDNEGNTPLHVAALNGH-ESTTLCLLYDPRVNKMTTNKEGKYVL 1117
               E+ ++D+   +NK D +GNT LH+AAL GH + TT  +     VNK   +K G+ VL
Sbjct: 83   QGAEVNKVDSDAEVNKGDKDGNTALHLAALGGHLDVTTYIISRGAEVNK--GDKGGRTVL 140

Query: 1116 DSITFNYDMRKAG-VYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVLSKAVMENQLD 940
             S  F   +R    +      V +GD         D  ++  D+++ +VL  A     L 
Sbjct: 141  HSAAFGGHLRVTKYLVSCGAEVNKGDN--------DAEVNKADDDDRTVLHGAAFGGHLK 192

Query: 939  CCKEIYRRCPSLLYSQ-NNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESGD-- 769
              K  Y  C     ++ + +G  ALH+AA +G   + ++LIS GA+    NK    G   
Sbjct: 193  VTK--YLICQGAEVNKGDKDGKTALHYAAIKGYPEITKYLISQGAE---VNKRDNHGQTA 247

Query: 768  VETIPNKKFLTMV-------------DGQGATALH-SAVNGVQLEAVKLLIE--ADSNKE 637
            +  +  K  L +              D  G TALH SAV+G  L+  K LI   A+ NK 
Sbjct: 248  LHVVAFKGHLDVTKYIFSRGAEVNKGDNDGRTALHISAVSG-HLDITKYLINQGAEVNK- 305

Query: 636  LLMMVTKKKATALHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNT 457
                 +K    ALH A  + +L++ K+L     ++    D  G T L +A          
Sbjct: 306  ----ASKDGLIALHIAAFEGHLDVTKYLFSRGAEVNK-GDNDGRTALHIAA--------V 352

Query: 456  SASAKIRKFLLKTQPSQGKAPIGDNRWTPLHYAAYKGDLNAIEDIIRYCPGCWEEVDNKK 277
            S    I K+L+       K  + D R T L+ AA+ G L    +I++Y      EV+   
Sbjct: 353  SGHLDITKYLISQGAEVNKGNV-DGR-TALYRAAFSGHL----EIVKYLISQGAEVNKGN 406

Query: 276  ---QNFLHIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMTLCLL 106
               +  LH A    H+++ K+++     A    N +D  G T LH AA++G+ ++T  L+
Sbjct: 407  DGGRTALHCAAFSGHLEIAKYLISQGAEA----NKEDIYGSTALHSAAVNGHYDVTKYLI 462

Query: 105  -YDPRVNKTTMSREGQSVLDSITF 37
                 VNK T+  +G + L    F
Sbjct: 463  SQGDEVNKATI--DGSTALHIAAF 484



 Score =  103 bits (257), Expect = 1e-19
 Identities = 140/498 (28%), Positives = 206/498 (41%), Gaps = 14/498 (2%)
 Frame = -1

Query: 1476 SQG-KAPSGNNGW-TPLHHASYDGDLSAIEDIIRFCPGSWEEVDNE---GKNFLHIAAMF 1312
            SQG +   GN+G  T LH A++ G L    +I ++      E + E   G   LH AA+ 
Sbjct: 397  SQGAEVNKGNDGGRTALHCAAFSGHL----EIAKYLISQGAEANKEDIYGSTALHSAAVN 452

Query: 1311 GVFKVVKYTLEIKEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLL-YDPRVNKMTTNK 1135
            G + V KY +         +NK   +G+T LH+AA  GH   T  L+     VNK   N 
Sbjct: 453  GHYDVTKYLIS----QGDEVNKATIDGSTALHIAAFGGHLDVTKYLISQGAEVNK--GND 506

Query: 1134 EGKYVLDSITFNYDMRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVLSKAVM 955
             G+  L    F+         G +E                             ++K ++
Sbjct: 507  GGRTALHRAAFS---------GHLE-----------------------------IAKYLI 528

Query: 954  ENQLDCCKEIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVES 775
                +  KE            +N G  ALH AA  G  ++ ++LIS GA       EV  
Sbjct: 529  SQGAEANKE------------DNYGSTALHSAAVNGHYDVTKYLISQGA-------EVNK 569

Query: 774  GDVETIPNKKFLTMVDGQGATALHSAVNGVQLEAVKLLI--EADSNKELLMMVTKKKATA 601
            GD +              G T LHSA  G  L+  K LI  EA+ NK       K   TA
Sbjct: 570  GDKD--------------GRTVLHSATFGGHLDVTKYLISQEAEGNKG-----DKDGKTA 610

Query: 600  LHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNTSASAKIRKFLLK 421
            LH A  K +L+I K+ +    D+       G+    +A+  A   G+      + K+L+ 
Sbjct: 611  LHLAAIKGHLDITKYFISQGADVN-----KGDNYGSIALHSAAANGHYD----VTKYLI- 660

Query: 420  TQPSQGKAPIGDNR--WTPLHYAAYKGDLNAIEDIIRYCPGC-WEEVDNKKQNFLHIAVM 250
               SQG     +N    T LH AAY G  +  + +I  C G    E DN   + LH A  
Sbjct: 661  ---SQGAEVNEENNRGVTALHKAAYNGHCDVTKYLI--CQGAEVNEGDNDGSSALHKAAH 715

Query: 249  FEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMTLCLL-YDPRVNKTTMS 73
              H+ V + ++         +N  D  G + LH AA++G+ ++T  L+     VNK   +
Sbjct: 716  NGHLDVTECLIS----QGAEVNKGDNYGSSALHSAAVNGHYDVTKYLISQGDEVNKA--N 769

Query: 72   REGQSVLDSITFD--YDK 25
             EG++ L S TF+  +DK
Sbjct: 770  NEGRTALHSATFEGHFDK 787



 Score = 95.9 bits (237), Expect = 2e-17
 Identities = 121/438 (27%), Positives = 183/438 (41%), Gaps = 8/438 (1%)
 Frame = -1

Query: 1326 IAAMFGVFKVVKYTLEIKEIDASVLNKQDNEGNTPLHVAALNGHESTTLCLL-YDPRVNK 1150
            +AA  G   + +Y +       + +NK D  G+T LH AA  GH   T  L+     VNK
Sbjct: 1    MAAQKGHLVITEYLVS----QGADVNKGDKNGSTALHTAAFRGHLDVTKYLIGQRAEVNK 56

Query: 1149 MTTNKEGKYVLDSITFNYDMRKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVL 970
                       D +T  +     G   V + +     E  +V + D  ++  D++ ++ L
Sbjct: 57   GDD--------DGMTALHSAVVGGHLDVTKYLTSQGAEVNKVDS-DAEVNKGDKDGNTAL 107

Query: 969  SKAVMENQLDCCKEIYRRCPSLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHAN 790
              A +   LD    I  R  + +   +  G   LH AA  G L + ++L+S GA      
Sbjct: 108  HLAALGGHLDVTTYIISR-GAEVNKGDKGGRTVLHSAAFGGHLRVTKYLVSCGA------ 160

Query: 789  KEVESGDVETIPNKKFLTMVDGQGATALHSAVNGVQLEAVKLLI--EADSNKELLMMVTK 616
             EV  GD +   NK      D    T LH A  G  L+  K LI   A+ NK       K
Sbjct: 161  -EVNKGDNDAEVNK-----ADDDDRTVLHGAAFGGHLKVTKYLICQGAEVNKG-----DK 209

Query: 615  KKATALHWAVEKQNLEIVKFLVETDPDMEYCADVSGETPLLMAMRQAQQGGNTSASAKIR 436
               TALH+A  K   EI K+L+    ++    D  G+T L +   +            + 
Sbjct: 210  DGKTALHYAAIKGYPEITKYLISQGAEVNK-RDNHGQTALHVVAFKGH--------LDVT 260

Query: 435  KFLLKTQPSQGKAPIGDNRW-TPLHYAAYKGDLNAIEDIIRYCPGCWEEVDNKKQN---F 268
            K++        K   GDN   T LH +A  G L    DI +Y      EV+   ++    
Sbjct: 261  KYIFSRGAEVNK---GDNDGRTALHISAVSGHL----DITKYLINQGAEVNKASKDGLIA 313

Query: 267  LHIAVMFEHVKVVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMTLCLL-YDPRV 91
            LHIA    H+ V K++          +N  D DG+T LH+AA+SG+ ++T  L+     V
Sbjct: 314  LHIAAFEGHLDVTKYLFS----RGAEVNKGDNDGRTALHIAAVSGHLDITKYLISQGAEV 369

Query: 90   NKTTMSREGQSVLDSITF 37
            NK  +  +G++ L    F
Sbjct: 370  NKGNV--DGRTALYRAAF 385



 Score = 82.0 bits (201), Expect = 4e-13
 Identities = 113/482 (23%), Positives = 194/482 (40%), Gaps = 16/482 (3%)
 Frame = -1

Query: 1446 GWTPLHHASYDGDLSAIEDIIRFCPGSWEEVDNEGKNFLHIAAMFGVFKVVKYTLEIKEI 1267
            G T LH A+  G L   E +I        + D  G   LH AA  G   V KY +     
Sbjct: 843  GKTALHLAANKGHLDITEHLISQ-GAEVNKGDKNGGTALHSAARSGHLVVTKYLIS---- 897

Query: 1266 DASVLNKQDNEGNTPLHVAALNGHESTTLCLL-YDPRVNKMTTNKEGKYVLDSITFNYDM 1090
                LNK+DN+G T LH AA++GH   T CL+     VNK   + +  +   +I  + D+
Sbjct: 898  QGDDLNKEDNDGRTALHSAAVSGHLDVTKCLISQGAEVNKGDKDGKTAFHFAAIKGHLDV 957

Query: 1089 RKAGVYGVMERVQRGDKEYFRVVALDVLLDSRDENNDSVLSKAVMENQLDCCKEIYRRCP 910
             K  + G    V +G+K+    +    +    +E    ++S+    N+ D          
Sbjct: 958  TKY-LIGKGAEVNKGEKDGKTALHFAAIKGHLEETK-YLISQGAEVNKWD---------- 1005

Query: 909  SLLYSQNNEGYIALHHAAHRGKLNMLQFLISVGAKTYHANKEVESGDVETIPNKKFLTMV 730
                    +G  ALH AA    L + ++LIS G  +  A+   E+ D             
Sbjct: 1006 -------KDGMTALHCAAFSSHL-VTKYLISQGLISQGADVNKENKD------------- 1044

Query: 729  DGQGATALHSAVNGVQLEAVKLLIE--ADSNKELLMMVTKKKATALHWAVEKQNLEIVKF 556
               G TAL  A +   ++  K LI   A+ N+E     T    TALH A    + ++ K+
Sbjct: 1045 ---GDTALGFAASNGHIDVTKYLISKGAEVNEE-----TDCGVTALHKAAYNGHCDVTKY 1096

Query: 555  LVETDPDMEYCADVSGETPLLMAMRQAQQGGNTSAS------------AKIRKFLLKTQP 412
            L+    ++       G+   L A+ +A Q G+ + +              + +FL+    
Sbjct: 1097 LISQGAEVN-----EGDNDGLSALHKAAQNGHLNVTECLIGQGAENGHLNVTEFLISQGS 1151

Query: 411  SQGKAPIGDNRWTPLHYAAYKGDLNAIEDIIRYCPGCWEEV-DNKKQNFLHIAVMFEHVK 235
               K    ++  TPLH A     L  ++ ++    G   ++ D + +  L ++++ ++  
Sbjct: 1152 DVNKG--NNDGVTPLHNAVQNDYLEVVKVLL--AGGARFDIGDIRGRTPLQLSLILQYRS 1207

Query: 234  VVKFVLGTKEVAATVLNGQDQDGKTPLHVAALSGNENMTLCLLYDPRVNKTTMSREGQSV 55
            +    +   +      +  DQ+    +H+A   G +  T+  L     N    S +GQ+ 
Sbjct: 1208 IYDLFIDRSD------SNLDQNVLRDIHLAIQQG-QTSTIEKLVSEGANLNVQSTDGQTC 1260

Query: 54   LD 49
            LD
Sbjct: 1261 LD 1262