BLASTX nr result
ID: Cimicifuga21_contig00003646
seq
BLASTX 2.2.25 [Feb-01-2011]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Cimicifuga21_contig00003646
(4429 letters)
Database: ./nr
23,641,837 sequences; 8,123,359,852 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
ref|XP_001347658.2| Pf11-1 protein [Plasmodium falciparum 3D7] g... 153 5e-34
pir||S00485 gene 11-1 protein precursor - malaria parasite (Plas... 144 2e-31
ref|XP_001348162.2| Antigen 332, DBL-like protein [Plasmodium fa... 137 3e-29
gb|AAF15293.3| erythrocyte membrane-associated giant protein ant... 134 3e-28
gb|ACJ64146.1| sporozoite-specific transmembrane protein S6 prec... 127 2e-26
>ref|XP_001347658.2| Pf11-1 protein [Plasmodium falciparum 3D7]
gi|254922499|gb|AAN35571.2| Pf11-1 protein [Plasmodium
falciparum 3D7]
Length = 9563
Score = 153 bits (386), Expect = 5e-34
Identities = 286/1408 (20%), Positives = 580/1408 (41%), Gaps = 42/1408 (2%)
Frame = -1
Query: 4138 DELFKAFKDSEDKVKPILTKTQEPESERQMQKDQTNDTVEATGDIIKGDKIDSCGEHA-L 3962
D+ K KD +D+ K ++ E + + +KD+ ++ E KG+K +S GE L
Sbjct: 335 DDEEKEEKDEKDEKDEKDEKDEKDEKDEKDEKDEKDEKDEKDEKDEKGEKDESKGEEKFL 394
Query: 3961 KKMSLDSARADNVGLVNSSALSTAPNDDDNIGEKLPAVPITSVSDDLNVQEGQTEGGNGA 3782
K+ + + + D+ + A IT + ++E TEG G
Sbjct: 395 KEEKMPKKEENMQDKIERDKEFEGFKDEYFTQMEGGAYGITVEHEGQKLRETLTEGVEGY 454
Query: 3781 D--MDDMEQKNDVIFDDKQAPVVEHLQSGDIIRHHLVGNSKEVNGDQLTEGICASQSIEE 3608
+ +++MEQ D+ P E G S + + E + S E
Sbjct: 455 EKVIEEMEQTK---LDEFLLPTNE-------------GKSDDFVSEMEEERLFNFVSYME 498
Query: 3607 DKAVTSSHEDQTEGTESGE-DPDLKSGXXXXXXXXXXXEYYDKEKVVADDLYTHNISIEE 3431
++ ++ +GTE DL D V+D++ IEE
Sbjct: 499 EEVKDKMFIEREQGTEEEVIHEDLSDEKIGIEKKELETFVQD----VSDEVLQDEQLIEE 554
Query: 3430 VKQSGFQEKELECKEQSSNSMGMVKDPEKIGQMEDRDYENKEGVKMVTEETSLQKSEVEE 3251
K + +E++L +E+ + + +D + I + + + E + +TEE L + E
Sbjct: 555 EKLT--EEEKLTEEEKLTEEEKLTEDEQLIEEEKLTEEEKLTEEEKLTEEEKLTEEE--- 609
Query: 3250 SWSPDNTHSHLLDETSLKPIDLQKERNDENATEPKIQDTKIMDIIGRVDIDDEEVPEQLE 3071
T L E K + +K +E TE +I I I +EV E LE
Sbjct: 610 ----KLTEEEKLTEEE-KLTEEEKLTEEEKLTEEEI-------FIEEDKISPKEVEEPLE 657
Query: 3070 KDQPEMEQNDRKELPPEMKH---EDLDFK--GNGAQDVDGTPIEQINQGSKMVQVTEVTH 2906
E + + KE+ E K +D+D K +D D P E I + V EVT
Sbjct: 658 DVLMEKMEKEYKEILHEGKSVVTQDMDEKLLSENLED-DLIPEEIIEELVDEELVEEVTA 716
Query: 2905 KDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPEEEINEGLDIGGAEEDTGEHIVEN 2726
++I EE + + E + KE E PEE+++E + EE E ++E
Sbjct: 717 EEIVEE-----FVAEVEIEE----KIPKELVEEVMPEEDVDEVVPEELVEEVVPEELIEG 767
Query: 2725 DVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKDDGETVMEEDVVPDPSTTTIGEEP 2546
+ + I E+ ++ E+ E++ V + E ++EE++ + + I +E
Sbjct: 768 VIPEELVEDVIPEKVLEKVIPEEIIEELVLEEVVEEIKHEELVEEEIPEEVTEEVIPDEV 827
Query: 2545 TKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDVSTTTIGEAQTKDVREEDKIIEGLN 2366
++ E+ + ++ K + V+K + E I++E V ++ + E ++V E+ I E +
Sbjct: 828 VEEVIPEELIEKVVKEELVEKVVAEEIVEEVVPEELVEKVVAEEIVEEVIPEELIEEVIT 887
Query: 2365 IDADEEVGDSITKDVVQDQSTTTIGEETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPA 2186
EEV I +++V++ I EE + E +E+ +P
Sbjct: 888 EKPAEEV---IPEELVEEVIPKEIVEEVLP--EEVVKEVIPEEVVEEVIPEELVEEVIP- 941
Query: 2185 TGEEPIKDGHEKEKIIEQPEIVGADREIREPVIEEDVVPDLSTTTTREE--PIQDGHDI- 2015
E I + E+++E+ + E+ E VI E++V ++ EE P + ++
Sbjct: 942 ---EEIVEEVVPEELVEEMK----PEEVVEEVISEELVEEMKPEEVVEEMKPEEVVEEVT 994
Query: 2014 -NKVIEGLEIASSNKDNGDPTIEGEVVPNHSITTIGEESTNDGQEEDKVVAELDIVDVHK 1838
KV+E + ++ + EV+ + + E + +KVV E+ ++ +
Sbjct: 995 PEKVVEEVVPEELVEEMKPEEVVEEVISEELVEEMKPEEVVEEVTPEKVVEEVVPEELVE 1054
Query: 1837 XXXXXXXXXXXXXDHSTTTIGEEPIQDGPAENKVIEGLEKVDLDEHIGEHITEKDVAPDH 1658
+ + E + + +++E ++ ++ E + ++V P+
Sbjct: 1055 EMKPEEVVEEVISEELVEEMKPEEVVEEVISEELVEEMKPEEVVEEVTPEKVVEEVVPEE 1114
Query: 1657 SITSFEEEPIKDFHEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHE 1478
+ + E + + ++++E + +++ + EE+VP+ ++ E + ++
Sbjct: 1115 LVEEMKPEEVVEEVISEELVEEMKPEEVVEEVTPEKVVEEVVPEELVEEMKPEEVVEEVI 1174
Query: 1477 EEKVIEELKIDGANKDIGESSIKDVVLDQSTTS--IGETPVKDA-HEEHKVRVGANKDIG 1307
E+++EE+K + +++ + + V+ + I E V +A HEE + ++
Sbjct: 1175 SEELVEEMKPEEVVEEVVPEELVEEVIPEEVVEEIIPEEVVHEAKHEELFEKTVPEVEVQ 1234
Query: 1306 EPIIKENVVLDH----PTKTIGE------IKDKHEEDKVIEGLDNDCVNXXXXXXXXXXX 1157
E I KE V + P + I E I++ E+ V E + + V
Sbjct: 1235 EIIPKELVEVIPEEVLPEELIEEVIPEEIIEEVIPEEVVEEVIPEEIVQEVIPEDLMEEV 1294
Query: 1156 GVREHSTKTTWEEPTKDGHEDKVIEGL---EIVDDVVPKPSTTITGEEAIRNGQEENKVI 986
E + EE ++ ++++E + E+V++VVP EE I E +
Sbjct: 1295 VPEEIIEEKILEEIVEEEIHEEIVEEIISEEVVEEVVPAEVV----EEMIPEKLVEEVIP 1350
Query: 985 EELEIVDAEEDIGEPIIEKDVVPGHT--TTIGEELINDVHDDNKVIEGFEMVGSDKDTGE 812
EEL EE I E ++E +VVP + E++ +V + V E ++ E
Sbjct: 1351 EEL----VEEVISEELVE-EVVPVEVLEEVVPVEVLEEVIPEEVVEEVIPEEFIEEMIPE 1405
Query: 811 PVVDDVIPEHSTTTSVGESIKDAHXXXXXXXXXXIVGADKEIREPAIKEDVVPD--LSTT 638
+V++V+PE E +++ V +E+ + E+V+P+ +
Sbjct: 1406 EIVEEVVPEVVEEVIPEELVEEV----------VPVELLEEVIPEELLEEVIPEELVEEV 1455
Query: 637 TREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIE--------EEVIPDHST-TIIGEEST 485
EE ++D + E + +++ + ++E EEVIP+ +I E
Sbjct: 1456 VPEELVEDVIPEELIAEVVSEELVEEEIPEEVLEEVIPEELVEEVIPEELVEEVIPEVLV 1515
Query: 484 NDGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEK 305
+ E+ V V+ V V++++ E ++E+ + EE + + E V E + +
Sbjct: 1516 EEVIPEELVEEVIPEVLVEEEVPEELVEEVIPELLVAEVIPEELVAEVIPEEFVEEVIPE 1575
Query: 304 VDLDKDIGEPITEKDVAPDNFIAAFEEEAIKDVHEEDKVIEETEIIGADKDIGDHIIGEE 125
+++ + E + E +V P+ + EE ++++ E+ VIEE K++ ++ EE
Sbjct: 1576 EVVEELVPEELVE-EVIPEEIVEEVVEEVVEEIIPEE-VIEEVIPEEIVKEVVPEVLVEE 1633
Query: 124 IVPDHSTTTIRGEPIQDGHEEDKVTEEL 41
+VP+ + E I + +++ EE+
Sbjct: 1634 VVPEEIVEEVVPEEIVEEVVPEELVEEV 1661
Score = 145 bits (366), Expect = 1e-31
Identities = 276/1320 (20%), Positives = 556/1320 (42%), Gaps = 62/1320 (4%)
Frame = -1
Query: 3781 DMDDMEQKNDVIFDDKQAPVVEHLQSGDIIRHHLVGNSKEVNGDQLTEGICASQSIEE-- 3608
DMD+ ++ D ++E L +++ +EV +++ E A IEE
Sbjct: 682 DMDEKLLSENLEDDLIPEEIIEELVDEELV--------EEVTAEEIVEEFVAEVEIEEKI 733
Query: 3607 -----DKAVTSSHEDQTEGTESGED---PDLKSGXXXXXXXXXXXEYYDKEKVVADDLYT 3452
++ + D+ E E+ +L G EKV+ +++
Sbjct: 734 PKELVEEVMPEEDVDEVVPEELVEEVVPEELIEGVIPEELVEDVIPEKVLEKVIPEEIIE 793
Query: 3451 HNIS---IEEVKQSGFQEKEL--ECKEQ--SSNSMGMVKDPEKIGQMEDRDYENK----E 3305
+ +EE+K E+E+ E E+ + V E I ++ + K E
Sbjct: 794 ELVLEEVVEEIKHEELVEEEIPEEVTEEVIPDEVVEEVIPEELIEKVVKEELVEKVVAEE 853
Query: 3304 GVKMVTEETSLQK---SEVEESWSPDNTHSHLLDETSLK---PIDLQKERNDENATEPKI 3143
V+ V E ++K E+ E P+ ++ E + P +L +E + E +
Sbjct: 854 IVEEVVPEELVEKVVAEEIVEEVIPEELIEEVITEKPAEEVIPEELVEEVIPKEIVEEVL 913
Query: 3142 QDTKIMDIIGRVDIDDEEVPEQL-EKDQPE--MEQNDRKELPPEMKHEDLDFKGNGAQDV 2972
+ + ++I ++ +E +PE+L E+ PE +E+ +EL EMK E++ + + V
Sbjct: 914 PEEVVKEVIPE-EVVEEVIPEELVEEVIPEEIVEEVVPEELVEEMKPEEVVEEVISEELV 972
Query: 2971 DGTPIEQINQGSKMVQVTE-VTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPE 2795
+ E++ + K +V E VT + + EE + + + E+ S+E E KPE
Sbjct: 973 EEMKPEEVVEEMKPEEVVEEVTPEKVVEEVVPEELVEEMKPEEVVEEVISEELVEEMKPE 1032
Query: 2794 EEINEGLDIGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKD 2615
E + E EE E +VE + I EE +++ E+ EV+ V +
Sbjct: 1033 EVVEEVTPEKVVEEVVPEELVEEMKPEEVVEEVISEELVEEMKPEEVVEEVISEELVEEM 1092
Query: 2614 DGETVMEE--------DVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIK 2459
E V+EE +VVP+ + E + ++++E K + V +++ +
Sbjct: 1093 KPEEVVEEVTPEKVVEEVVPEELVEEMKPEEVVEEVISEELVEEMKPEEVVEEVTPEKVV 1152
Query: 2458 ENVVPDVSTTTIGEAQTKDVREE---DKIIEGLNID--ADEEVGDSITKDVVQDQSTTTI 2294
E VVP+ + E + ++V EE ++++E + + +E V + + ++V+ ++ I
Sbjct: 1153 EEVVPE---ELVEEMKPEEVVEEVISEELVEEMKPEEVVEEVVPEELVEEVIPEEVVEEI 1209
Query: 2293 GEETI--KCGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQPEIV 2120
E + + HEE E +P EE + + +E I E+
Sbjct: 1210 IPEEVVHEAKHEELFEKTVPEVEVQEIIPKELVEVIP---EEVLPEELIEEVIPEEIIEE 1266
Query: 2119 GADREIREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEV 1940
E+ E VI E++V ++ EE + + K++E + +++ + I EV
Sbjct: 1267 VIPEEVVEEVIPEEIVQEVIPEDLMEEVVPEEIIEEKILEEIVEEEIHEEIVEEIISEEV 1326
Query: 1939 VPNHSITTIGEESTNDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQ 1760
V + EE + E+ + EL + + + + EE I
Sbjct: 1327 VEEVVPAEVVEEMIPEKLVEEVIPEELVEEVISEELVEEVVPVEVLEEVVPVEVLEEVIP 1386
Query: 1759 DGPAENKVIEGLEKVDLDEHIGEHITEK---DVAPDHSI-----TSFEEEPIKDFHEEDK 1604
+ E + E + + E I E + + +V P+ + EE I + E+
Sbjct: 1387 EEVVEEVIPEEFIEEMIPEEIVEEVVPEVVEEVIPEELVEEVVPVELLEEVIPEELLEEV 1446
Query: 1603 VIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGANKDIG 1424
+ E +++ + +I EE++ + + + E I ++ EE + EEL + +++
Sbjct: 1447 IPEELVEEVVPEELVEDVIPEELIAEVVSEELVEEEIPEEVLEEVIPEELVEEVIPEELV 1506
Query: 1423 ESSIKDVVLDQSTTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDH-PTKTIGE- 1250
E I +V++++ I E V++ E V +++ E +I E +V + P + + E
Sbjct: 1507 EEVIPEVLVEEV---IPEELVEEVIPEVLVEEEVPEELVEEVIPELLVAEVIPEELVAEV 1563
Query: 1249 IKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVIEGL-- 1076
I ++ E+ + E + + V + E + EE ++ ++VIE +
Sbjct: 1564 IPEEFVEEVIPEEVVEELV-----PEELVEEVIPEEIVEEVVEEVVEEIIPEEVIEEVIP 1618
Query: 1075 -EIVDDVVPKPSTTITGEEAIRNGQEENKVIEELEIVDAEEDIGEPIIEKDVVPGHTTTI 899
EIV +VVP+ + EE + E V EE+ E++ E ++ ++++ I
Sbjct: 1619 EEIVKEVVPE----VLVEEVVPEEIVEEVVPEEIVEEVVPEELVEEVVPEELIE---EVI 1671
Query: 898 GEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAHXXXXXXX 719
EEL+ +V + V E V ++ E +V++VIPE V E + +
Sbjct: 1672 PEELVEEVIPEVLVEEVIPEVLVEEMVLEELVEEVIPEVLVEEMVPEEVVEKMVLEEVVE 1731
Query: 718 XXXIVGADKEIREPAIKEDVVPD--LSTTTREEPIQDGHDINKVGEGLEIAGSDKDNGDP 545
+E+ E V+P+ + EE I++ V E L ++ +
Sbjct: 1732 EVIPEEVVEEVIPEEDVEQVIPEELIEEVVPEEVIEEVITEEVVEEVLP-----EELVEK 1786
Query: 544 IIEEEVIPDHSTTIIGEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPNHSTTTT 365
++EEE++ + +I EE + E+ + V+ V+K + E ++E+ V+
Sbjct: 1787 VVEEEILEE----VIPEELVEEVVREELIEEVVTEELVEKVVEEEIVEEVVLAEVVEEVI 1842
Query: 364 GEEPIQDGQAENKVIEGLEKVDLDKDIGEPITEKDVAPDNFIA-AFEEEAIKDVHEEDKV 188
+E +++ E V E + K +++ I E + E +V P+ +A EE + +V E+ +
Sbjct: 1843 PQEIVEEVIPEEVVEEVIPKEIVEEVIPEELVE-EVVPEELVAEVIPEELVAEVIPEE-L 1900
Query: 187 IEETEIIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEELKIDGAKKDIGE 8
IEE +++ + +I EE+V + + E + + E+ V EEL + ++I E
Sbjct: 1901 IEEV----VTEELVEEVIPEEVVEEVIPEEVVEEVVPEELVEEVVPEELVEEVVPEEIVE 1956
Score = 136 bits (342), Expect = 6e-29
Identities = 259/1189 (21%), Positives = 501/1189 (42%), Gaps = 42/1189 (3%)
Frame = -1
Query: 3481 EKVVADDLYTHNISIEEVKQSGFQEKELECKEQSSNSMGMVKD--PEKIGQMEDRDYENK 3308
E+VV ++L + EE+ + E E +EQ +V++ PE++ + + +
Sbjct: 2417 EEVVPEEL-VEEVVPEELVEEVVPEVVEEVQEQ------LVEEFIPEEVVE----ELVPE 2465
Query: 3307 EGVKMVTEETSLQK---SEVEESWSPDNTHSHLLDETSLK---PIDLQKERNDENATEPK 3146
E V+ V E +++ E+ E P+ ++ E ++ P +L +E E E
Sbjct: 2466 ELVEEVIPEELVEEVIPEEIVEEVLPEEVVKEVIPEEVVEEVIPEELVEEVIPEEIVEEV 2525
Query: 3145 IQDTKIMDIIGRVDIDDEEVPEQL-EKDQPE--MEQNDRKELPPEMKHEDLDFKGNGAQD 2975
+ + + ++I ++ +E +PE+L E+ PE +E+ +EL E+ E+L +
Sbjct: 2526 LPEEVVKEVIPE-EVVEEVIPEELVEEVIPEELVEEVIPEELVEEVVSEELV-----EEV 2579
Query: 2974 VDGTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPE 2795
+ +E++ + +V E +I EE + + + T E+ E KE PE
Sbjct: 2580 IPEEIVEEVIPEELLEEVVEEVVPEIVEEVVP-EVVEEVITEEVIPEELIKE----VIPE 2634
Query: 2794 EEINEGLDIGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKD 2615
E + E + EE E IVE + + + E +++ E+ EVL V +
Sbjct: 2635 ELVEEVIPEEIVEEVIPEEIVEEVISEEVVEEVVPEVVVEEVIPEEIVEEVLPKEIVEEV 2694
Query: 2614 DGETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDVS 2435
E V+EE + + I EE ++ E ++ EI + +++ + E +I+E + ++
Sbjct: 2695 ISEKVVEEMIPEELVEEVIPEEVVEEVIPEVEIEEILPEELIEELVAEEVIEEVIPKELI 2754
Query: 2434 TTTIGEAQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCGHEEER 2255
I E +DV E+ + E L +E V + I ++VV++ + EE I E
Sbjct: 2755 EEVIPEKLIEDVVPEEIVEEVL---PEEVVKEVIPEEVVEEVLPEELVEEVIP---EVVE 2808
Query: 2254 ELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQPEIVGADREIREPVIEEDV 2075
E+ +P E I E+IIE E+V +E+ E VI +++
Sbjct: 2809 EVVPEELVEEVLPKEVVEEVIPEVEIEEIL----PEEIIE--ELVA--KEVIEEVIPKEL 2860
Query: 2074 VPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVVPNHSITTIGEESTN 1895
+ + T EE I + ++IE EVVP I + E
Sbjct: 2861 IEEAITEEVVEEMIPE-----EIIE------------------EVVPEEVIEEVITEEVV 2897
Query: 1894 DGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAENKVIEGLEKV 1715
+ ++V+ E+ +V + I EE +++ E ++ E L +
Sbjct: 2898 EEVVPEEVIEEVITEEVVE-----------------EAIPEEVVEEVIPEVEIEEVLPEE 2940
Query: 1714 DLDEHIGEHITEKDVAP---DHSITSFEEEPIKDFHEEDKVIEGTEIVGADKDIGDPIIG 1544
++E + E +TE+ + + +I+ EE I + ++ + E ++I + II
Sbjct: 2941 LIEELVPEEVTEEVITEEVVEEAISEVVEEVIPEEIVKEVIPEEVVEEIITEEIAEEIIP 3000
Query: 1543 ----EEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGANKDIGESSIKDVVLDQSTTSI 1376
EE++P+ I E + ++ E+++EEL + E ++ VV ++ I
Sbjct: 3001 KELVEEVIPEEVVVEIIPEKLVEEFVSEELVEEL--------VPEEIVEKVVPEELVEEI 3052
Query: 1375 -GETPVKDAHEEHKVRVGANKDIGEPIIKENVVLD-HPTKTIGEIKDKHEEDKVIEGLDN 1202
E V++ E V +++ E I E VV + P + + E+ + E+ V E L
Sbjct: 3053 VPEELVEEVVPEELVEEVIPEELVEEFIPEEVVEEVLPEQLVEEVISEVVEEVVPEELVE 3112
Query: 1201 DCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVIEGLEIVDDVVPKPSTTITGEE 1022
+ + + E K EE + E+ + E EIV++V+P EE
Sbjct: 3113 EVIPEEVVEELVAEEVIEEVIPKELIEEAITEEVEEVIPE--EIVEEVIP--------EE 3162
Query: 1021 AIRNGQEENKVIEELEIVD-AEEDIGEPIIEKDVVPGHTT------TIGEELINDVHDDN 863
++ +VI E+EI + E++ E ++ K+V+ T I EE++ +V +
Sbjct: 3163 VVK------EVIPEVEIEEILPEELIEELVAKEVIEEVITEEVAEEVIPEEIVQEVIPEE 3216
Query: 862 KVIEGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAHXXXXXXXXXXIVGA-DKEI 686
V E V ++ E ++D+V+PE T + E + KE+
Sbjct: 3217 VVEEIITEVEIEEVLPEELIDEVVPEEVTEEVITEEVMPEEVVKEVIPEEIAEEVIPKEL 3276
Query: 685 REPAIKEDVVPDLSTTTREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHST- 509
E I E+VV ++ E + I +V +EI EE+IPD
Sbjct: 3277 VEEVIPEEVVEEIIPEVEIEEVLPEEVIEEVVPEVEI-------------EELIPDEVVE 3323
Query: 508 TIIGEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAEN 329
++ EE + E+ V V+ +++ + E ++E+ + EE I+ E
Sbjct: 3324 EVLPEELVEEVIPEEVAVEVVPEEVIEEAVPEEIVEEFIPEEQIEEVIQEEIIEQVVPEE 3383
Query: 328 KVIEGLEKVDLDKDIGEPITE----KDVAPDNFI-AAFEEEAIKDVHEE--------DKV 188
+ E + + +++ I E I E ++V P+ + E+ +K++ E +++
Sbjct: 3384 LIEEVVPEEIIEEVIPEEIVEEVIYEEVIPEELVEEVIAEKLVKEIVPEQVREEVTLEEI 3443
Query: 187 IEETEIIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEEL 41
+EE +++ + EEI+P+ + E I + E+ V EEL
Sbjct: 3444 VEEMIPEEFVEEVAPEVEIEEIIPEE----LIEEVIPEVLVEEAVPEEL 3488
Score = 135 bits (340), Expect = 1e-28
Identities = 245/1142 (21%), Positives = 503/1142 (44%), Gaps = 41/1142 (3%)
Frame = -1
Query: 3310 KEGVKMVTEETSLQKSEVEESWS---PDNTHSHLLDETSLKPI---DLQKERNDENATEP 3149
KE V+ V E +++ EE + P+ + ++ E ++ + +L +E E E
Sbjct: 1862 KEIVEEVIPEELVEEVVPEELVAEVIPEELVAEVIPEELIEEVVTEELVEEVIPEEVVEE 1921
Query: 3148 KIQDTKIMDIIGRVDIDDEEVPEQL-EKDQPE--MEQNDRKELPPEMKHEDLDFKGNGAQ 2978
I + + +++ ++ +E VPE+L E+ PE +E+ KE+ E+ +E+ Q
Sbjct: 1922 VIPEEVVEEVVPE-ELVEEVVPEELVEEVVPEEIVEELLPKEVVEEVIYEE--------Q 1972
Query: 2977 DVDGTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKP 2798
+ P E + + V EV +++ EE ++L E+ +E E P
Sbjct: 1973 VEEVIPEELVAEVIPEKLVEEVIPEELVEEVIP-EELVEEVVPEVVEEVVPEELVEEVIP 2031
Query: 2797 EEEINEGLDIGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGK 2618
EE + E + EE+ E +VE + + + EE I+ E+ EV V +
Sbjct: 2032 EELVEEVIPEVLVEEEVPEELVEEVIPEELVEEMLPEELIEVVVPEELVEEV-----VPE 2086
Query: 2617 DDGETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDV 2438
+ E V+ E+VV + + EE + E+ + E + V ++I E +I + ++ +V
Sbjct: 2087 ELVEEVVPEEVVEEVIPEELIEELVPEVEIEEILPEELIEELVPEEIIEEVIPKELIEEV 2146
Query: 2437 STTTIGEAQTKDVREE--DKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCGHE 2264
+ E +V EE +I+E + + EEV + +++++++ + + EE +
Sbjct: 2147 IPEVVVEEVVPEVVEEVVPEIVEEVVPEVVEEV---VPEEIIEEKISEEVVEEVLPKEIV 2203
Query: 2263 EE---RELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQ--PEIVGADREIR 2099
EE EL V E + + E ++E+ PE+V + EI
Sbjct: 2204 EEVIPEELVEEVVPEELVAEVIPEELVEEVIPEVLFEEEIPEVVVEEVVPEVV--EEEIP 2261
Query: 2098 EPVIEEDVVPDLSTTTTREEPIQD--GHDINKVIEGLEIASSNKDNGDPTIEGEVVPNHS 1925
E V+EE VVP++ EE +++ ++ + + E+A EV+P
Sbjct: 2262 EVVVEE-VVPEVVEEVIPEELVEEVIPEELIEEVIPEEVAE------------EVLPEEL 2308
Query: 1924 ITTIGEESTNDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAE 1745
I + E + +++VAE+ ++ + + EE +++ +
Sbjct: 2309 IEEVIPEELVEEVVPEELVAEVIPEEIVEEVVREELVEE--------VVPEEVVEEVIPK 2360
Query: 1744 NKVIEGLEKVDLDEHIGEHITEKDVAPDHSITSFEEEPIKDFHEEDKVIEGTEIVGADKD 1565
V E + + ++E I + I E++V P+ + EE +++ E+ V E ++
Sbjct: 2361 EIVEEVVSEEVVEEVIPKEIVEEEV-PEELVEVVPEELVEEVVPEELVEEVVPEELVEEV 2419
Query: 1564 IGDPIIGEEIVPDHSTTTIRGEPIQDDHEE-------EKVIEELKIDGANKD-IGESSIK 1409
+ + ++ EE+VP+ + E +++ E+ E+V+EEL + ++ I E ++
Sbjct: 2420 VPEELV-EEVVPEELVEEVVPEVVEEVQEQLVEEFIPEEVVEELVPEELVEEVIPEELVE 2478
Query: 1408 DVVLDQSTTSI-GETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDH-PTKTIGEIKDKH 1235
+V+ ++ + E VK+ E V +++ E +I E +V + P + + E+ +
Sbjct: 2479 EVIPEEIVEEVLPEEVVKEVIPEEVVEEVIPEELVEEVIPEEIVEEVLPEEVVKEVIPEE 2538
Query: 1234 EEDKVI----------EGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVI 1085
++VI E L + + V E + EE + ++V+
Sbjct: 2539 VVEEVIPEELVEEVIPEELVEEVIPEELVEEVVSEELVEEVIPEEIVEEVIPEELLEEVV 2598
Query: 1084 EGL--EIVDDVVPKPSTTITGEEAIRNGQEENKVIEELEIVDAEEDIGEPIIEKDVVPGH 911
E + EIV++VVP+ + EE I + + EEL EE I E I+E +V+P
Sbjct: 2599 EEVVPEIVEEVVPEVVEEVITEEVIPEELIKEVIPEEL----VEEVIPEEIVE-EVIP-- 2651
Query: 910 TTTIGEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAHXXX 731
EE++ +V + V E V ++ E +V++V+P+ + E + +
Sbjct: 2652 -----EEIVEEVISEEVVEEVVPEVVVEEVIPEEIVEEVLPKEIVEEVISEKVVEEMIP- 2705
Query: 730 XXXXXXXIVGADKEIREPAIKEDVVPDLSTTTREEPIQDGHDINK-VGEGLEIAGSDKDN 554
+E+ E I E+VV ++ E I I + V E + K+
Sbjct: 2706 ------------EELVEEVIPEEVVEEVIPEVEIEEILPEELIEELVAEEVIEEVIPKEL 2753
Query: 553 GDPIIEEEVIPDHSTTIIGEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPNHST 374
+ +I E++I D ++ EE + E+ V V+ V++ + E ++E+ V+P
Sbjct: 2754 IEEVIPEKLIED----VVPEEIVEEVLPEEVVKEVIPEEVVEEVLPEELVEE-VIPEVVE 2808
Query: 373 TTTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPITEKDVAPDNFIAAFEEEAIKDVHEED 194
EE +++ + V E + +V++++ + E I E+ VA + +E I++ E+
Sbjct: 2809 EVVPEELVEEVLPKEVVEEVIPEVEIEEILPEEIIEELVAKEVIEEVIPKELIEEAITEE 2868
Query: 193 KVIEETEIIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEELKIDGAKKDI 14
V+EE ++I + ++ EE++ + T + E + + E+ +TEE+ + +++
Sbjct: 2869 -VVEEM----IPEEIIEEVVPEEVIEEVITEEVVEEVVPEEVIEEVITEEVVEEAIPEEV 2923
Query: 13 GE 8
E
Sbjct: 2924 VE 2925
Score = 134 bits (338), Expect = 2e-28
Identities = 232/1117 (20%), Positives = 480/1117 (42%), Gaps = 62/1117 (5%)
Frame = -1
Query: 3196 PIDLQKERNDENATEPKIQDTKIMDIIGRVDIDDEEVPEQLEKDQPE--MEQNDRKELPP 3023
P ++ +E + E + + + ++I + +I +EEVPE+L + PE +E+ +EL
Sbjct: 2350 PEEVVEEVIPKEIVEEVVSEEVVEEVIPK-EIVEEEVPEELVEVVPEELVEEVVPEELVE 2408
Query: 3022 EMKHEDLDFKGNGAQDVDGTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGEL 2843
E+ E+L + + V+ E++ + + +V E + + EE + + + EL
Sbjct: 2409 EVVPEELVEEVVPEELVEEVVPEELVE-EVVPEVVEEVQEQLVEEFIPEEVVEELVPEEL 2467
Query: 2842 AGIESSKEDNEAKKPEEEINEGLDIGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHK 2663
+E E PEE + E L +E E +VE + + I EE +++
Sbjct: 2468 VEEVIPEELVEEVIPEEIVEEVLPEEVVKEVIPEEVVEEVIPEELVEEVIPEEIVEEVLP 2527
Query: 2662 EDKANEVLEIAGVGKDDGETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDK 2483
E+ EV+ V + E ++EE + + I EE ++ E+ V E+ + V++
Sbjct: 2528 EEVVKEVIPEEVVEEVIPEELVEEVIPEELVEEVIPEELVEEVVSEELVEEVIPEEIVEE 2587
Query: 2482 DIGESIIKE-------NVVPDVSTTTIGEAQTKDVREEDKIIEGLNIDADEEVGDSITKD 2324
I E +++E +V +V + E T++V E+ I E + + EEV I ++
Sbjct: 2588 VIPEELLEEVVEEVVPEIVEEVVPEVVEEVITEEVIPEELIKEVIPEELVEEV---IPEE 2644
Query: 2323 VVQDQSTTTIGEETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEK 2144
+V++ I EE I E E+ +P E + EK
Sbjct: 2645 IVEEVIPEEIVEEVIS--EEVVEEVVPEVVVEEVIPEEIVEEVLPKEIVEEVIS----EK 2698
Query: 2143 IIEQ--PEIVGADREIREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKD 1970
++E+ PE E+ E VI E+VV ++ EE + + ++IE L ++
Sbjct: 2699 VVEEMIPE------ELVEEVIPEEVVEEVIPEVEIEEILPE-----ELIEELVAEEVIEE 2747
Query: 1969 NGDPTIEGEVVPNHSITTIGEESTNDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHS 1790
+ EV+P I + E + ++VV E+ +V + +
Sbjct: 2748 VIPKELIEEVIPEKLIEDVVPEEIVEEVLPEEVVKEVIPEEVVEEVLPEELVEEVIPEVV 2807
Query: 1789 TTTIGEEPIQDGPAENKVIEGLEKVDLDEHIGEHITEK--------DVAPDHSIT-SFEE 1637
+ EE +++ + V E + +V+++E + E I E+ +V P I + E
Sbjct: 2808 EEVVPEELVEEVLPKEVVEEVIPEVEIEEILPEEIIEELVAKEVIEEVIPKELIEEAITE 2867
Query: 1636 EPIKDFHEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEE 1457
E +++ E+ + E ++ I + ++ EE+VP+ + E + ++ E+V+EE
Sbjct: 2868 EVVEEMIPEEIIEEVVPEEVIEEVITEEVV-EEVVPEEVIEEVITEEVVEEAIPEEVVEE 2926
Query: 1456 LKIDGANKDI-GESSIKDVVLDQSTTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENVV 1280
+ + +++ E I+++V ++ T + V + V ++I + +I E VV
Sbjct: 2927 VIPEVEIEEVLPEELIEELVPEEVTEEVITEEVVEEAISEVVEEVIPEEIVKEVIPEEVV 2986
Query: 1279 LDHPTKTIGE-------IKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWE 1121
+ T+ I E +++ E+ V+E + V E K E
Sbjct: 2987 EEIITEEIAEEIIPKELVEEVIPEEVVVEIIPEKLVEEFVSEELVEELVPEEIVEKVVPE 3046
Query: 1120 EPTKDGHEDKVIEGL---EIVDDVVPKPSTTITGEEAIRNGQEENKVIEELEIVDAEEDI 950
E ++ ++++E + E+V++V+P+ E + +++EE+ EE +
Sbjct: 3047 ELVEEIVPEELVEEVVPEELVEEVIPEELVEEFIPEEVVEEVLPEQLVEEVISEVVEEVV 3106
Query: 949 GEPIIEKDVVPGHTTT--IGEELINDVHD----DNKVIEGFEMVGSDKDTGEPVVDDVIP 788
E ++E +V+P + EE+I +V + + E E V ++ E + ++V+
Sbjct: 3107 PEELVE-EVIPEEVVEELVAEEVIEEVIPKELIEEAITEEVEEVIPEEIVEEVIPEEVVK 3165
Query: 787 EHSTTTSVGESIKDAHXXXXXXXXXXIVGADKEIREPAIKEDVVPDLSTTTREEPIQDGH 608
E + E + + +E+ E I E++V ++ E I
Sbjct: 3166 EVIPEVEIEEILPEELIEELVAKEVIEEVITEEVAEEVIPEEIVQEVIPEEVVEEIITEV 3225
Query: 607 DINKV-GEGLEIAGSDKDNGDPIIEEEVIPDH----------STTIIGEESTNDGHEEDK 461
+I +V E L ++ + +I EEV+P+ + +I +E + E+
Sbjct: 3226 EIEEVLPEELIDEVVPEEVTEEVITEEVMPEEVVKEVIPEEIAEEVIPKELVEEVIPEEV 3285
Query: 460 VVAVLDIVGVDKDIGEPVIEDNV--------VPNHSTTTT-GEEPIQDGQAENKVIEGLE 308
V ++ V +++ + E VIE+ V +P+ EE +++ E +E +
Sbjct: 3286 VEEIIPEVEIEEVLPEEVIEEVVPEVEIEELIPDEVVEEVLPEELVEEVIPEEVAVEVVP 3345
Query: 307 KVDLDKDIGEPITEKDVAPDNFIAAFEEEAIKDVHEEDKVIEET---EIIGA--DKDIGD 143
+ +++ + E I E+ + + +EE I+ V E+ +IEE EII ++I +
Sbjct: 3346 EEVIEEAVPEEIVEEFIPEEQIEEVIQEEIIEQVVPEE-LIEEVVPEEIIEEVIPEEIVE 3404
Query: 142 HIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEELKID 32
+I EE++P+ + E + ++V EE+ ++
Sbjct: 3405 EVIYEEVIPEELVEEVIAEKLVKEIVPEQVREEVTLE 3441
Score = 133 bits (335), Expect = 4e-28
Identities = 238/1073 (22%), Positives = 462/1073 (43%), Gaps = 21/1073 (1%)
Frame = -1
Query: 3196 PIDLQKERNDENATEPKIQDTKIMDIIGRVDIDDEEVPEQL-EKDQPE--MEQNDRKELP 3026
P +L +E E E I + + ++I + +E +PE+L E+ PE +E+ +EL
Sbjct: 4202 PEELIEEVIPEEIVEEVIPEELVAEVIPE-KLVEEVIPEELVEEVIPEELVEEVIPEELV 4260
Query: 3025 PEMKHEDLDFKGNGAQDVDGTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGE 2846
E+ E++ + + P E I + + EV +++ EE + T E
Sbjct: 4261 EEVLPEEVVEEAVPEVVEEIVPEELIEEVIPEELIKEVVPEEVIEE---------VITEE 4311
Query: 2845 LAGIESSKEDNEAKKPEEEINEGLDIGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAH 2666
+ +E E PEE I E + EE E +VE V + + EE +++
Sbjct: 4312 VVEEVLPEEIVEEVLPEEVIEEVVPEELVEEVLPEEVVEEVVPEELVEEVVPEELVEEVI 4371
Query: 2665 KEDKANEVLEIAGVGKDDGETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVD 2486
E+ EVL V + + ++EE + + I EE ++ E+ V E+ +
Sbjct: 4372 PEELVEEVLPEEVVEEVVPKELVEELIPEELVEEVIPEELVEEVVPEELVAEV-----IP 4426
Query: 2485 KDIGESIIKENVVPDVSTTTIGEAQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQS 2306
+++ E +I E +V +V + E + + E+ I+E L +E V + + ++VV ++
Sbjct: 4427 EELVEEVIPEELVEEVIPEELVEEEIPEELVEEVILEEL---VEEVVPEELIEEVVPEE- 4482
Query: 2305 TTTIGEETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQPE 2126
+ EE + EE I++ EK+I +
Sbjct: 4483 ---LIEEVVP--------------------------------EELIEE--VVEKVIPE-- 4503
Query: 2125 IVGADREIREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNGDPTIEG 1946
EI E V+ E+V+ ++ T EE + + KVIE E+ + +
Sbjct: 4504 ------EIIEEVVPEEVIEEVITEEVVEEVVPE-----KVIE--EVITEE-------VVE 4543
Query: 1945 EVVPNHSITTIGEESTNDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEP 1766
EVVP I + E + ++V+ E+ I +V + I EE
Sbjct: 4544 EVVPEEVIDEVITEEVVEEVVPEEVIEEVIIEEVVEEVVPEEVI--------EEVITEEV 4595
Query: 1765 IQDGPAENKVIEGLEKVDLDEHIGEHITEKDVAPDHSITSFEEEPIKDFHEE---DKVIE 1595
+++ E V E + +V ++E I E + E+ + + EE I++ EE +K++E
Sbjct: 4596 VEEAIPEELVEEVIPEVLVEEEIPEELVEEVILEELVEEVVAEELIEEVVEEVIPEKLVE 4655
Query: 1594 GT---EIVG--ADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGANKD 1430
EIV +++ + ++ EE+V + + E I ++ EE + EEL + +++
Sbjct: 4656 EVIPEEIVEEVIPEELVEVVVPEELVEEVIPEELVEEVIHEELVEEVIPEELVEEVIHEE 4715
Query: 1429 IGESSIKDVVLDQSTTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDHPTKTIGE 1250
I E I + V+++ I E V++ E + + + E ++ E V P + + E
Sbjct: 4716 IVEEVIPEEVVEE---VIPEEIVEEVVPEELLEEVIPELLVEEVVPEVVEEVVPVELLEE 4772
Query: 1249 IKDKHEEDKVI-EGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVIEGLE 1073
+ ++ ++VI E L + ++ V+E T+ EE + +++I +
Sbjct: 4773 VVEEVITEEVIPEELIKEVISEELVEELIPEEVVQEVITEEVLEEVIPEEIVEELIPE-K 4831
Query: 1072 IVDDVVPKPSTTITGEEAIRNGQEENKVIEEL-EIVDAEEDIGEPIIEKDVVPGHTTTIG 896
++ +VVP+ EE + E + EE+ E V EE + E I+E + VP
Sbjct: 4832 LIGEVVPEKVV----EEVVLEEVVEEVIPEEIVEEVITEEVLAEEIVE-EFVP------- 4879
Query: 895 EELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAHXXXXXXXX 716
EEL+ ++ + V E V ++ E +V++V+PE V E I +
Sbjct: 4880 EELVEEMLPEEVVEERVREVEIEEMVPEVLVEEVLPE-----VVEEVITEEVVEEMVPEE 4934
Query: 715 XXIVGADKEIREPAIKEDVVPDLSTTTREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIE 536
KEI E + E+VV ++ EE +++ V E L ++ + ++
Sbjct: 4935 VVEEMVPKEIVEEVLPEEVVEEV---IPEEVVEE-----MVPEVLVEEVVPEEIVEKVVP 4986
Query: 535 EEVIPDHSTTIIGEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEE 356
EEV+ + ++ EE + E+ V ++ V++ + E +IE+ V EE
Sbjct: 4987 EEVVEE----VVAEEIIEEVITEEVVEEIVPGEVVEEMVPEEIIEEVVPEEVIEEVITEE 5042
Query: 355 PIQDGQAENKVIEGLEKVDLDKDIGEPITEKDVAPDNFIAAFEEEAIKDVHEEDKV---- 188
+++ E V E + ++ ++ +I E + E +V P+ + EE +++V E+ V
Sbjct: 5043 VVEEVIPEELVEEVIPEISVEVEIPEVLVE-EVIPEKLVKVVPEELVEEVIPEELVEEVI 5101
Query: 187 ----IEETEIIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEEL 41
+EE + ++I + ++ EE+V + + E + + E+ V EEL
Sbjct: 5102 TEALVEEVVDVVVPEEIFEEVLPEEVVEEVIPEEVVEEMVPEEVVEEVVPEEL 5154
Score = 129 bits (325), Expect = 5e-27
Identities = 273/1196 (22%), Positives = 517/1196 (43%), Gaps = 38/1196 (3%)
Frame = -1
Query: 3481 EKVVADDLYTHNISIEEVKQSGFQEKELECKEQSSNSMGMVKDPEKIGQMEDRDYENKEG 3302
E+VV ++L + EE+ + E+ LE + + +K E I ++ R+ +
Sbjct: 5951 EEVVPEELVEKKVP-EEIVEEVIYEEFLE-EIMPEELIEEMKPEELIEEIIPREIVEEII 6008
Query: 3301 VKMVTEETSLQKSEVEESWSPDNTHSHLLDETSLKPIDLQKERNDENATEPKIQDTKIMD 3122
+ V EE ++ E+ E P+ ++ E ++ +E E E I + I +
Sbjct: 6009 TEEVVEE--MKPEELVEEMVPEEVVEEMVPE------EVVEEMVPEEVVEEVITEKLIEE 6060
Query: 3121 IIGRVDIDDEEVPEQLEKDQPEMEQNDRKELPPEMKHEDLDFKGNGAQDVDGTPIEQINQ 2942
++ +I +E +PE+L ++ + + +E+ PE E++ + + V IE++
Sbjct: 6061 VVPE-EIIEELIPEELVEEV--IPEKLIEEMIPEEVVEEMLLEEVVEEVVPEVEIEEMIP 6117
Query: 2941 GSKMVQVT--EVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPEEEINEGLDI 2768
+ +V E+ K+I E + I T E+ E PEE + E +
Sbjct: 6118 EQLVEEVVPEELVEKEIPEV------VEEIITEEVV---------EEMVPEEVVEEMVPE 6162
Query: 2767 GGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKDDGETVMEE- 2591
EE E ++E V ++ + EE I++ E E++ V + E ++EE
Sbjct: 6163 EVVEEVILEKLIEEVVPVEVIEEVVPEEVIEEVIPEKLIEEIIPEVLVEEVVPEELIEEV 6222
Query: 2590 -------DVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDVST 2432
+VVP+ + EE + E+ V E+ + V++ I E I++E V ++
Sbjct: 6223 IPEVLFEEVVPEVVEEVVPEELVEKVVPEEIVEEVIP-EFVEEVISEEIVEEVVTEELIE 6281
Query: 2431 TTIGEAQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCGHEEERE 2252
I E ++V E+ + E + ++ EEV + +++++ + EE + E E
Sbjct: 6282 EMIPEEVVEEVIPEELVEEVVPVELIEEV---VPVELLEEVIPEELVEEVVPV--ELIEE 6336
Query: 2251 LXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEK--EKIIEQ--PEIVGADREIREPVIE 2084
+ +P +E + + E+ +++E+ PE+V E+ V+E
Sbjct: 6337 VVPVELLEEVIPEEVVEEVIPEVVKEVVPEVVEEVVPEVVEEVVPEVV---EEVVPEVVE 6393
Query: 2083 EDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVVPNHSITTIGEE 1904
E V +L EE I++ +VIE L+ ++ + EV+P I EE
Sbjct: 6394 EVVPEELIEEVIPEELIKEVLP-EEVIEELKPEELIEEIIPEEVVEEVIPEELI----EE 6448
Query: 1903 STNDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAENKVIEGL 1724
+ E++V EL V + + I EE I + E E
Sbjct: 6449 MIPELLVEEEVPEEL----VEEVIPEVLVEEMVPEEIVEEVIPEELIAEFAPE----ELF 6500
Query: 1723 EKVDLDEHIGEHITEKDVAPDHSITSFEEEPIKDFHEE---DKVIEGTEIVGAD--KDIG 1559
EKV +E + E ++E+ V + + EE + + EE ++VIE EIV + +++
Sbjct: 6501 EKVIPEEVVEELVSEELV--EEVLPEVVEEVLPEVFEEVIPEEVIE--EIVPEEVMEEVV 6556
Query: 1558 DPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGANKDIGESSIKDVVLDQSTTS 1379
+ EE++P+ + E + ++ EK+IEE+ I E IK+VV ++
Sbjct: 6557 PKELIEEVIPEELIEEVIPEEVAEEVVPEKLIEEV--------IPEELIKEVVPEELIEE 6608
Query: 1378 -IGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDH-PTKTIGEIKDKHEEDKVI-EGL 1208
I E V++A E V +++ E +I E ++ + P + I EI + ++VI E L
Sbjct: 6609 VITEEVVEEAISEELVEEVVPEEVVEEVIPEELIEEVVPEELIEEIIPEELVEEVIPEEL 6668
Query: 1207 DNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVIEGLEIVDDVVPKPSTTITG 1028
+ V V E + EE + +K+I E+V++V+P+ +
Sbjct: 6669 VEEVV---------PEELVEEVIPEELVEEVVPEELVEKLIPE-ELVEEVIPE----LLV 6714
Query: 1027 EEAIRNGQEENKVIEELEIVDAEEDIGEPIIEKDVVPGHTT--TIGEELINDVHDDNKVI 854
EE + E + EEL EE I E ++E +V+P I EEL+ +V + V
Sbjct: 6715 EEVVPEEVVEELIPEEL----VEEVIPEELVE-EVIPEEVPEEVIREELVEEVIPEELVE 6769
Query: 853 EGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAHXXXXXXXXXXIVGADKEIREPA 674
E ++ E +V +VIPE V E + + +E+
Sbjct: 6770 EVIPEEVPEEVVPEELVQEVIPEELVEEVVHEEVPEEVVPEKLVEEVIPEELFEEVVPEE 6829
Query: 673 IKEDVVPD--LSTTTREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHSTTII 500
+ E+VVP+ + EE +++ V E + ++ + ++EE + + I
Sbjct: 6830 VPEEVVPEELVEEVISEELVEEVIPEELVEEFIPEELVEEVIPEELVEEVIPEELVEEFI 6889
Query: 499 GEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVI 320
EE + E+ V V+ V V+++I E ++E+ VVP EE I + E V
Sbjct: 6890 PEELVEEVIPEELVEEVIPEVLVEEEIPEKLVEE-VVPEELV----EEVIPEVLVEEVVT 6944
Query: 319 EGL-EKVDLDKDIGEPITE---KDVAPDNFIA-AFEEEAIKDVHEEDKVIEET------- 176
E + E+V ++ + E + E K+V P+ + EE +++V E+ V+EE
Sbjct: 6945 EEVPEEVVPEELVAEVVPEELVKEVIPEELVEEVIPEEIVEEVIPEE-VVEEVVPEELVE 7003
Query: 175 EIIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEELKIDGAKKDIGE 8
E+I +++ + +I EE+V + + E + + E+ + EEL + ++I E
Sbjct: 7004 EVI--PEEVVEEVIPEELVEEVVPVELVEEVVPEELVEEVIPEELVEEVIPEEIVE 7057
Score = 129 bits (324), Expect = 7e-27
Identities = 232/1096 (21%), Positives = 463/1096 (42%), Gaps = 48/1096 (4%)
Frame = -1
Query: 3151 PKIQDTKIMDIIGRV--DIDDEEVPEQLEKDQPEMEQNDRKELPPEMKHEDLDFKGNGAQ 2978
P++ + + +++ V ++ +E VPE +E+ PE+ + E+ PE+ E + +
Sbjct: 3667 PEVVEEVVPEVVEEVVPEVVEEVVPEVVEEVVPEVVE----EVVPEVVEEVVP------E 3716
Query: 2977 DVDGTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKP 2798
V+ E + + V EV + + EE ++L + EL +E E P
Sbjct: 3717 VVEEVVPEVVEEVVPEELVEEVIPEVLFEEEIP-EELVEVVPVELLEEAIPEELVEEVIP 3775
Query: 2797 EEEINEGLDIGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGK 2618
EE + E + EE E +VE ++ + I EE +++ E+ EV+ V +
Sbjct: 3776 EELVEEVIPEELVEEVIPEELVEEVILEELVEEVIPEELVEEVIPEELVEEVIPEVLVEE 3835
Query: 2617 DDGETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDV 2438
+ E ++EED+ + EE + E+ V E+ + V + I E ++KE VVP+
Sbjct: 3836 EIPEKLVEEDIPEKLVEEVVPEELVEVVIPEELVEEVIPEELVKEVIPEELVKE-VVPEE 3894
Query: 2437 STTTIGEAQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCGHEEE 2258
++V E+ + E + + EEV I ++VV ++ + E ++
Sbjct: 3895 LVEEEIPKVVEEVLPEELVEEVMLEEVVEEVVPEIVEEVVPEELVEEVVPEVVE--EVVP 3952
Query: 2257 RELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQ--PEIVGAD-------RE 2105
E+ V +E + + KE+++E+ PE++ + E
Sbjct: 3953 EEIVEEVIPEELVEEVVKEELVEEVVKEELVEEVVKEELVEEVIPEVLVEEVVPEELLEE 4012
Query: 2104 IREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVVPNHS 1925
+ V+ E+V+P+L E I++ V+ P + EVVP
Sbjct: 4013 VIPKVLVEEVIPELLVEEVVPEVIEE------VV--------------PEVVEEVVPEEL 4052
Query: 1924 ITTIGEESTNDGQEEDKVVAELDIVD-VHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPA 1748
+ + E + + +K+V E+ + V + + I EE +++
Sbjct: 4053 LEEVIPEVLVEEEIPEKLVEEVVPEELVEEVIPEVLVEEVVPEELVEEVISEELVEEVIP 4112
Query: 1747 ENKVIEGLEKVDLDEHIGEHITE------KDVAPD---HSITSFEEEPIKDFHEE--DKV 1601
E V E + + ++E + E + E ++V P+ + EE + + EE +V
Sbjct: 4113 EELVEEVIPEEVVEEVVPEVVEEVVPEVVEEVVPEVVEEVVPEVVEEVVPEVVEEVVPEV 4172
Query: 1600 IEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGANKDIGE 1421
+E E+V + P + EE+VP+ + E I++ EE V E + + + I E
Sbjct: 4173 VE--EVVPEVVEEVVPEVVEEVVPEVVEEVVPEELIEEVIPEEIVEEVIPEELVAEVIPE 4230
Query: 1420 SSIKDVVLDQSTTS-IGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDHPTKTIGE-- 1250
+++V+ ++ I E V++ E V +++ E + E V P + I E
Sbjct: 4231 KLVEEVIPEELVEEVIPEELVEEVIPEELVEEVLPEEVVEEAVPEVVEEIVPEELIEEVI 4290
Query: 1249 ----IKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVIE 1082
IK+ E+ + E + + V E + EE ++ ++V+E
Sbjct: 4291 PEELIKEVVPEEVIEEVITEEVVEEVLPEEIVEEVLPEEVIEEVVPEELVEEVLPEEVVE 4350
Query: 1081 GL---EIVDDVVPKPSTT-ITGEEAIRNGQEENKVIEELEIVDAEEDIGEPIIEKDVVPG 914
+ E+V++VVP+ + EE + E V E + EE I E ++E +V+P
Sbjct: 4351 EVVPEELVEEVVPEELVEEVIPEELVEEVLPEEVVEEVVPKELVEELIPEELVE-EVIP- 4408
Query: 913 HTTTIGEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAHXX 734
EEL+ +V + V E ++ E +V++VIPE + E + +
Sbjct: 4409 ------EELVEEVVPEELVAEVIPEELVEEVIPEELVEEVIPEELVEEEIPEELVEEVIL 4462
Query: 733 XXXXXXXXIVGADKEIREPAIKEDVVPD------LSTTTREEPIQDGHDINKVGEGLEIA 572
+E+ + E+VVP+ + EE I++ + E +
Sbjct: 4463 EELVEEVVPEELIEEVVPEELIEEVVPEELIEEVVEKVIPEEIIEEVVPEEVIEEVITEE 4522
Query: 571 GSDKDNGDPIIEEEVIPDHSTTIIGEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIEDNV 392
++ + +IEE + + ++ EE ++ E+ V V+ +++ I E V+E+ V
Sbjct: 4523 VVEEVVPEKVIEEVITEEVVEEVVPEEVIDEVITEEVVEEVVPEEVIEEVIIEEVVEEVV 4582
Query: 391 VPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPITEKDVAPDNFIAAFEEEAIK 212
EE +++ E V E + +V ++++I E + E+ + + EE I+
Sbjct: 4583 PEEVIEEVITEEVVEEAIPEELVEEVIPEVLVEEEIPEELVEEVILEELVEEVVAEELIE 4642
Query: 211 DVHEE---DKVIEET---EIIGA--DKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDK 56
+V EE +K++EE EI+ +++ + ++ EE+V + + E I + E+
Sbjct: 4643 EVVEEVIPEKLVEEVIPEEIVEEVIPEELVEVVVPEELVEEVIPEELVEEVIHEELVEEV 4702
Query: 55 VTEELKIDGAKKDIGE 8
+ EEL + ++I E
Sbjct: 4703 IPEELVEEVIHEEIVE 4718
Score = 129 bits (324), Expect = 7e-27
Identities = 222/1075 (20%), Positives = 467/1075 (43%), Gaps = 23/1075 (2%)
Frame = -1
Query: 3196 PIDLQKERNDENATEPKIQDTKIMDIIGRVDIDDEEVPEQLEKDQPEMEQNDRKELPPEM 3017
P++L +E E E I + + ++I ++ +E +PE+L ++ +E+ + +P E+
Sbjct: 3757 PVELLEEAIPEELVEEVIPEELVEEVIPE-ELVEEVIPEELV-EEVILEELVEEVIPEEL 3814
Query: 3016 KHEDLDFKGNGAQDVDGTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAG 2837
E + P E + + V V E + + EE K + + EL
Sbjct: 3815 VEEVI-------------PEELVEEVIPEVLVEEEIPEKLVEEDIPEKLVEEVVPEELVE 3861
Query: 2836 IESSKEDNEAKKPEEEINEGLDIGGAEEDTGEHIVENDV--ILDHNRTTIQEEAIKDAHK 2663
+ +E E PEE + E + +E E +VE ++ +++ + EE +++
Sbjct: 3862 VVIPEELVEEVIPEELVKEVIPEELVKEVVPEELVEEEIPKVVEE---VLPEELVEEVML 3918
Query: 2662 EDKANEVLEIAGVGKDDGETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDK 2483
E+ EV + + ++ + E+VVP+ + EE ++ E+ V E+ K + V++
Sbjct: 3919 EEVVEEV--VPEIVEEVVPEELVEEVVPEVVEEVVPEEIVEEVIPEELVEEVVKEELVEE 3976
Query: 2482 DIGESIIKENVVPDVSTTTIGEAQTKDVREEDKIIEGL-NIDADEEVGDSITKDVVQDQS 2306
+ E +++E V ++ I E ++V E+ + E + + +E + + + ++VV +
Sbjct: 3977 VVKEELVEEVVKEELVEEVIPEVLVEEVVPEELLEEVIPKVLVEEVIPELLVEEVVPEVI 4036
Query: 2305 TTTIGEETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQ-- 2132
+ E + EE E V E + + E+++E+
Sbjct: 4037 EEVVPEVVEEVVPEELLE------------EVIPEVLVEEEIPEKLVEEVVPEELVEEVI 4084
Query: 2131 PEIVGAD---REIREPVIEEDVVPDLSTTTTREEPIQDG---HDINKVIEGLEIASSNKD 1970
PE++ + E+ E VI E++V ++ EE I + + +V+E E+ +
Sbjct: 4085 PEVLVEEVVPEELVEEVISEELVEEVIPEELVEEVIPEEVVEEVVPEVVE--EVVPEVVE 4142
Query: 1969 NGDPTIEGEVVPN---HSITTIGEESTNDGQEE--DKVVAELDIVDVHKXXXXXXXXXXX 1805
P + EVVP + + EE + EE +VV E+ + +V +
Sbjct: 4143 EVVPEVVEEVVPEVVEEVVPEVVEEVVPEVVEEVVPEVVEEV-VPEVVEEVVPEVVEEVV 4201
Query: 1804 XXDHSTTTIGEEPIQDGPAENKVIEGLEKVDLDEHIGEHITEKDVAPDHSITSFEEEPIK 1625
+ I EE +++ E V E + + ++E I E + E+ + + EE ++
Sbjct: 4202 PEELIEEVIPEEIVEEVIPEELVAEVIPEKLVEEVIPEELVEEVIPEELVEEVIPEELVE 4261
Query: 1624 DFHEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKID 1445
+ E+ V E V ++ + + +I EE++P+ + E + ++ E+V+EE+ +
Sbjct: 4262 EVLPEEVVEEAVPEV-VEEIVPEELI-EEVIPEELIKEVVPEEVIEEVITEEVVEEVLPE 4319
Query: 1444 GANKDI-GESSIKDVVLDQSTTSI-GETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDH 1271
+++ E I++VV ++ + E V++ E V +++ E +I E +V +
Sbjct: 4320 EIVEEVLPEEVIEEVVPEELVEEVLPEEVVEEVVPEELVEEVVPEELVEEVIPEELVEEV 4379
Query: 1270 -PTKTIGEIKDKHEEDKVI-EGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHE 1097
P + + E+ K +++I E L + + V E + EE +
Sbjct: 4380 LPEEVVEEVVPKELVEELIPEELVEEVIPEELVEEVVPEELVAEVIPEELVEEVIPEELV 4439
Query: 1096 DKVIEGLEIVDDVVPKPSTTITGEEAIRNGQEENKVIEEL-EIVDAEEDIGEPIIEKDVV 920
++VI E+V++ +P+ EE I E V EEL E V EE I E + E+ +
Sbjct: 4440 EEVIPE-ELVEEEIPEELV----EEVILEELVEEVVPEELIEEVVPEELIEEVVPEELIE 4494
Query: 919 PGHTTTIGEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAH 740
I EE+I +V + + E ++ E V+++VI E V E + D
Sbjct: 4495 EVVEKVIPEEIIEEVVPEEVIEEVITEEVVEEVVPEKVIEEVITEEVVEEVVPEEVIDEV 4554
Query: 739 XXXXXXXXXXIVGADKEIREPAIKEDVVPD--LSTTTREEPIQDGHDINKVGEGLEIAGS 566
+E+ + E+VVP+ + EE +++ V E +
Sbjct: 4555 ITEEVVEEVVPEEVIEEVIIEEVVEEVVPEEVIEEVITEEVVEEAIPEELVEEVIPEVLV 4614
Query: 565 DKDNGDPIIEEEVIPDHSTTIIGEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVP 386
+++ + ++EE ++ + ++ EE + EE V+ V++ I E ++E+ +
Sbjct: 4615 EEEIPEELVEEVILEELVEEVVAEELIEEVVEE-----VIPEKLVEEVIPEEIVEEVIPE 4669
Query: 385 NHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPITEKDVAPDNFIAAFEEEAIKDV 206
EE +++ E V E + + +++ I E + E+ + + EE +++V
Sbjct: 4670 ELVEVVVPEELVEEVIPEELVEEVIHEELVEEVIPEELVEEVIHEEIVEEVIPEEVVEEV 4729
Query: 205 HEEDKVIEETEIIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEEL 41
E+ ++EE +++ ++ EE+VP+ + E +++ EE +TEE+
Sbjct: 4730 IPEE-IVEEVVPEELLEEVIPELLVEEVVPEVVEEVVPVELLEEVVEE-VITEEV 4782
Score = 128 bits (321), Expect = 2e-26
Identities = 221/1104 (20%), Positives = 458/1104 (41%), Gaps = 61/1104 (5%)
Frame = -1
Query: 3169 DENATEPKIQDTKI-MDIIGRVDIDDEEVPEQLEKDQPEMEQNDRKELPPEMKHEDLDFK 2993
D E K +D + D G D DDEE E+ E+D E E+ D K+ E +D
Sbjct: 301 DRGGDENKDKDNEENKDKKGNKDDDDEEEEEE-EEDDEEKEEKDEKDEKDEKDEKD---- 355
Query: 2992 GNGAQDVDGTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDN 2813
+ ++ + + E KD K+E D K S GE ++ K
Sbjct: 356 -------------EKDEKDEKDEKDEKDEKDEKDEK-DEKGEKDESKGEEKFLKEEKMPK 401
Query: 2812 EAKKPEEEINEGLDIGGAEED--TGEHIVENDVILDHNRTTIQE---------EAIKDAH 2666
+ + +++I + G +++ T + ++H ++E E + +
Sbjct: 402 KEENMQDKIERDKEFEGFKDEYFTQMEGGAYGITVEHEGQKLRETLTEGVEGYEKVIEEM 461
Query: 2665 KEDKANEVLEIAGVGK-DDGETVMEEDVVPDPSTTTIGEEPTKD----GHEEDKVIEISK 2501
++ K +E L GK DD + MEE+ + + + EE KD E+ E+
Sbjct: 462 EQTKLDEFLLPTNEGKSDDFVSEMEEERL--FNFVSYMEEEVKDKMFIEREQGTEEEVIH 519
Query: 2500 IDSVDKDIG-ESIIKENVVPDVSTTTIGEAQ---TKDVREEDKIIEGLNIDADEEVGDSI 2333
D D+ IG E E V DVS + + Q + + EE+K+ E + +E++ +
Sbjct: 520 EDLSDEKIGIEKKELETFVQDVSDEVLQDEQLIEEEKLTEEEKLTEEEKLTEEEKLTED- 578
Query: 2332 TKDVVQDQSTTTIGEETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHE 2153
+ +++++ T + T + EE +L T EE + E
Sbjct: 579 -EQLIEEEKLTEEEKLTEEEKLTEEEKLTEEE---------------KLTEEEKLT---E 619
Query: 2152 KEKIIEQPEIVGADREIREPV-IEEDVVPDLSTTTTREEPIQD------GHDINKVI-EG 1997
+EK+ E+ ++ ++ E + IEED + EEP++D + +++ EG
Sbjct: 620 EEKLTEEEKLTEEEKLTEEEIFIEEDKISPKEV----EEPLEDVLMEKMEKEYKEILHEG 675
Query: 1996 LEIASSNKDNG--DPTIEGEVVPNHSITTIGEESTNDGQEEDKVVAE-LDIVDVHKXXXX 1826
+ + + D +E +++P I + +E + +++V E + V++ +
Sbjct: 676 KSVVTQDMDEKLLSENLEDDLIPEEIIEELVDEELVEEVTAEEIVEEFVAEVEIEEKIPK 735
Query: 1825 XXXXXXXXXDHSTTTIGEEPIQDGPAENKVIEGLEKVDL-DEHIGEHITEKDVAPDHSIT 1649
+ + EE +++ E ++IEG+ +L ++ I E + EK V P+ I
Sbjct: 736 ELVEEVMPEEDVDEVVPEELVEEVVPE-ELIEGVIPEELVEDVIPEKVLEK-VIPEEIIE 793
Query: 1648 SFE-EEPIKDFHEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEE 1472
EE +++ E+ V E ++ I D ++ EE++P+ + E + + E
Sbjct: 794 ELVLEEVVEEIKHEELVEEEIPEEVTEEVIPDEVV-EEVIPEELIEKVVKEELVEKVVAE 852
Query: 1471 KVIEELKIDG-ANKDIGESSIKDVVLDQSTTS-IGETPVKDAHEEHKVRVGANKDIGEPI 1298
+++EE+ + K + E +++V+ ++ I E P ++ E V K+I E +
Sbjct: 853 EIVEEVVPEELVEKVVAEEIVEEVIPEELIEEVITEKPAEEVIPEELVEEVIPKEIVEEV 912
Query: 1297 IKENVVLDHPTKTIGEIKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEE 1118
+ E VV + + + +++ E+ V E + + V E + EE
Sbjct: 913 LPEEVVKEVIPEEV--VEEVIPEELVEEVIPEEIVEEVVPEELVEEMKPEEVVEEVISEE 970
Query: 1117 PTKDGHEDKVIEGL---EIVDDVVP-KPSTTITGEEAIRNGQEE--------NKVIEELE 974
++ ++V+E + E+V++V P K + EE + + E +++EE++
Sbjct: 971 LVEEMKPEEVVEEMKPEEVVEEVTPEKVVEEVVPEELVEEMKPEEVVEEVISEELVEEMK 1030
Query: 973 IVDAEEDIGEPIIEKDVVPGHTT-----------TIGEELINDVHDDNKVIEGFEMVGSD 827
+ E++ + ++VVP I EEL+ ++ + V E +
Sbjct: 1031 PEEVVEEVTPEKVVEEVVPEELVEEMKPEEVVEEVISEELVEEMKPEEVVEEVISEELVE 1090
Query: 826 KDTGEPVVDDVIPEHSTTTSVGESIKDAHXXXXXXXXXXIVGADKEIREPAIKEDVVPD- 650
+ E VV++V PE V E + + +E++ + E+V P+
Sbjct: 1091 EMKPEEVVEEVTPEKVVEEVVPEELVEEMKPEEVVEEVISEELVEEMKPEEVVEEVTPEK 1150
Query: 649 -LSTTTREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHSTTIIGEESTNDGH 473
+ EE +++ V E + ++ + ++EE V + +I EE +
Sbjct: 1151 VVEEVVPEELVEEMKPEEVVEEVISEELVEEMKPEEVVEEVVPEELVEEVIPEEVVEEII 1210
Query: 472 EEDKVVAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLD 293
E+ V +K + E +++ ++P EE + + E + E + + +
Sbjct: 1211 PEEVVHEAKHEELFEKTVPEVEVQE-IIPKELVEVIPEEVLPEELIEEVIPEEIIEEVIP 1269
Query: 292 KDIGEPITEKDVAPDNFIAAFEEEAIKDVHEEDKVIEETEIIGADKDIGDHIIGEEIVPD 113
+++ E + +++ + EE + + E+K++EE ++I + II EE+V +
Sbjct: 1270 EEVVEEVIPEEIVQEVIPEDLMEEVVPEEIIEEKILEEIVEEEIHEEIVEEIISEEVVEE 1329
Query: 112 HSTTTIRGEPIQDGHEEDKVTEEL 41
+ E I + E+ + EEL
Sbjct: 1330 VVPAEVVEEMIPEKLVEEVIPEEL 1353
Score = 127 bits (320), Expect = 2e-26
Identities = 237/1080 (21%), Positives = 457/1080 (42%), Gaps = 17/1080 (1%)
Frame = -1
Query: 3196 PIDLQKERNDENATEPKIQDTKIMDIIGRVDIDDEEVPEQLEKDQ-PE--MEQNDRKELP 3026
P +L +E E E + + I ++I ++ +E VPE+L + PE +E+ R+EL
Sbjct: 2287 PEELIEEVIPEEVAEEVLPEELIEEVIPE-ELVEEVVPEELVAEVIPEEIVEEVVREELV 2345
Query: 3025 PEMKHEDLDFKGNGAQDVDGTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGE 2846
E+ E++ ++V P E + + V EV K+I EE ++L + E
Sbjct: 2346 EEVVPEEV------VEEV--IPKEIVEEVVSEEVVEEVIPKEIVEEEVP-EELVEVVPEE 2396
Query: 2845 LAGIESSKEDNEAKKPEEEINEGLDIGGAEEDTGEHIVENDV--ILDHNRTTIQEEAIKD 2672
L +E E PEE + E + EE E +VE V +++ + + EE I +
Sbjct: 2397 LVEEVVPEELVEEVVPEELVEEVVPEELVEEVVPEELVEEVVPEVVEEVQEQLVEEFIPE 2456
Query: 2671 AHKEDKANEVLEIAGVGKDDGETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDS 2492
E+ E L + ++ E V+ E++V + + EE K+ E+ V E+ +
Sbjct: 2457 EVVEELVPEELVEEVIPEELVEEVIPEEIVEE----VLPEEVVKEVIPEEVVEEVIPEEL 2512
Query: 2491 VDKDIGESIIKENVVPDVSTTTIGEAQTKDVREEDKIIEGLNIDADEEV-GDSITKDVVQ 2315
V++ I E I++E + +V I E ++V E+ + E + + EEV + + ++VV
Sbjct: 2513 VEEVIPEEIVEEVLPEEVVKEVIPEEVVEEVIPEELVEEVIPEELVEEVIPEELVEEVVS 2572
Query: 2314 DQSTTTIGEETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIE 2135
++ + E I EE VP EE I + E++I+
Sbjct: 2573 EELVEEVIPEEIV---EEVIPEELLEEVVEEVVPEIVEEVVPEVVEEVITEEVIPEELIK 2629
Query: 2134 Q--PEIVGADREIREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNGD 1961
+ PE E+ E VI E++V ++ EE I + +V+E E+
Sbjct: 2630 EVIPE------ELVEEVIPEEIVEEVIPEEIVEEVISE-----EVVE--EVVPE------ 2670
Query: 1960 PTIEGEVVPNHSITTIGEESTNDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTTT 1781
+ EV+P + + + + +KVV E+
Sbjct: 2671 -VVVEEVIPEEIVEEVLPKEIVEEVISEKVVEEM-------------------------- 2703
Query: 1780 IGEEPIQDGPAENKVIEGLEKVDLDEHIGEHITEKDVAPDHSITSFEEEPIKDFHEE--- 1610
I EE +++ E V E + +V+++E + E + E+ VA + EE K+ EE
Sbjct: 2704 IPEELVEEVIPEEVVEEVIPEVEIEEILPEELIEELVAEE----VIEEVIPKELIEEVIP 2759
Query: 1609 DKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGANKD 1430
+K+IE D+ I EE++P+ + E + ++ E+++EE+ + +
Sbjct: 2760 EKLIE---------DVVPEEIVEEVLPEEVVKEVIPEEVVEEVLPEELVEEVIPEVVEEV 2810
Query: 1429 IGESSIKDVVLDQSTTS-IGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDHPTKTIG 1253
+ E +++V+ + I E +++ E + K++ E +I + ++ + T+ +
Sbjct: 2811 VPEELVEEVLPKEVVEEVIPEVEIEEILPEEIIEELVAKEVIEEVIPKELIEEAITEEVV 2870
Query: 1252 E--IKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVIEG 1079
E I ++ E+ V E + + + + E T+ EE +
Sbjct: 2871 EEMIPEEIIEEVVPEEVIEEVITEEVVEEVVPEEVIEEVITEEVVEEAIPE--------- 2921
Query: 1078 LEIVDDVVPKPSTTITGEEAIRNGQEENKVIEELEIVDAEEDIGEPIIEKDVVPGHTTTI 899
E+V++V+P+ + EE + E V EE+ EE I E ++E+ + I
Sbjct: 2922 -EVVEEVIPE----VEIEEVLPEELIEELVPEEV----TEEVITEEVVEEAISEVVEEVI 2972
Query: 898 GEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAHXXXXXXX 719
EE++ +V + V E +++ + +V++VIPE + E + +
Sbjct: 2973 PEEIVKEVIPEEVVEEIITEEIAEEIIPKELVEEVIPEEVVVEIIPEKLVEEF------- 3025
Query: 718 XXXIVGADKEIREPAIKEDVVPDLSTTTREEPIQDGHDINKVGEGLEIAGSDKDNGDPII 539
+E+ E + E++V + E I V E L ++ + +I
Sbjct: 3026 ------VSEELVEELVPEEIVEKVVPEELVEEI--------VPEELVEEVVPEELVEEVI 3071
Query: 538 EEEVIPDHSTTIIGEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGE 359
EE++ + + EE + E+ + V++ V V +++ E VI + VV E
Sbjct: 3072 PEELVEEFIPEEVVEEVLPEQLVEEVISEVVEEV-VPEELVEEVIPEEVVEELVAEEVIE 3130
Query: 358 EPIQDGQAENKVIEGLEKVDLDKDIGEPITE---KDVAPDNFIAAFEEEAIKDVHEEDKV 188
E I E + E +E+V ++ + E I E K+V P+ I E + + +V
Sbjct: 3131 EVIPKELIEEAITEEVEEVIPEEIVEEVIPEEVVKEVIPEVEIEEILPEELIEELVAKEV 3190
Query: 187 IEETEIIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEELKIDGAKKDIGE 8
IEE +++ + +I EEIV + + E I + E+ + EEL + +++ E
Sbjct: 3191 IEEV----ITEEVAEEVIPEEIVQEVIPEEVVEEIITEVEIEEVLPEELIDEVVPEEVTE 3246
Score = 126 bits (317), Expect = 5e-26
Identities = 244/1128 (21%), Positives = 478/1128 (42%), Gaps = 43/1128 (3%)
Frame = -1
Query: 3262 EVEESWSPDNTHSHLLDETSLK---PIDLQKERNDENATEPKIQDTKIMDIIGRVDIDD- 3095
EV E P+ L+ E ++ P +L +E E E I I ++I V +++
Sbjct: 7823 EVVEEVIPEELIEELVPEVEIEEILPEELIEELVPEEIIEEVIPKELIEEVIPEVVVEEV 7882
Query: 3094 -------EEVPEQL----------EKDQPE--MEQNDRKELPPEMKHEDLDFKGNGAQDV 2972
E VPE+L E++ PE +E +EL E+ E+L + + V
Sbjct: 7883 VPEVLVEEVVPEELVEEVIPEVLVEEEVPEELVEDVIPEELVEEVVPEELVEEVIPEEVV 7942
Query: 2971 DGT-PIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPE 2795
+ P E + + V EV +++ EE + + + E+ +E E PE
Sbjct: 7943 EEVLPEELVEEVVPEEIVEEVIPEELVEEEVPEELVEEVIPEEVVEEVIPEEVPEKVIPE 8002
Query: 2794 EEINEGLDIGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKD 2615
+ + E + EE E +VE V ++ + E +++ E EV+ V +
Sbjct: 8003 KLVEELIPEEVVEELIPEEVVEEMVPIEVVEEVVPTEVLEEVIPEIVVEEVVPEELVEEV 8062
Query: 2614 DGETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDVS 2435
E ++EE + + EE ++ E+ V E+ + V++ + E I++E + ++
Sbjct: 8063 IPEELVEEVIPEIVVEEVVPEELVEEVIPEELVEEVVPEELVEEVVPEEIVEELLPKEIV 8122
Query: 2434 TTTIGEAQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCGHEEER 2255
I E Q ++V E+ + E + + EEV + ++VV + I EE ++ E
Sbjct: 8123 EEVIYEEQVEEVIHEELVAEVIPEEVVEEVVPEVVEEVVPEIVAEVIPEEVVEEVVPEVV 8182
Query: 2254 ELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQ------PEIVGAD--REIR 2099
E VP EE I + +E I E+ PE + + E+
Sbjct: 8183 E-----------------EVVPEVVEEVIPEEVVEEVIPEEFIEEMIPEEIVEEVVPEVV 8225
Query: 2098 EPVIEEDVVPDLSTTTTREEPIQD---GHDINKVIEGLEIASSNKDNGDPTIEGEVVPNH 1928
E VI E++V ++ EE I + +I +V+ + ++ + EVVP
Sbjct: 8226 EEVIPEELVAEVIPEELVEEVIPEVLFEEEIPEVVVEEVVPEVVEEEIPEVVVEEVVPEV 8285
Query: 1927 SITTIGEESTNDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPA 1748
I EE + E+ VV E+ +++ + T + EE I +
Sbjct: 8286 VEEVIPEEVVEELIPEE-VVEEMVPIEIVEEVV-------------PTEVLEEVIPEIVV 8331
Query: 1747 ENKVIEGLEKVDLDEHIGEHITEKDVAPDHSITSFEEEPIKDFHEEDKVIEGTEIVGADK 1568
E V E L ++E I E + E +V P+ + E +++ E V+E +
Sbjct: 8332 EEVVPEEL----VEEVIPEELVE-EVVPEELVEEVVPEVVEEVVPE--VVEEVVPEELVE 8384
Query: 1567 DIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGANKDIGESSIKDVVLDQS 1388
++ ++ EE+VP+ + E + ++ E+++EE+ +++ E + +V++++
Sbjct: 8385 EVIPEVVVEEVVPEELVEEVIPEELVEEIIPEEIVEEV----IPEELIEEVVPEVLVEE- 8439
Query: 1387 TTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLD-HPTKTIGE-IKDKHEEDKVIE 1214
I E V++ E +++ +I E +V + P + I E + ++ E++V E
Sbjct: 8440 --VIPEELVEEVIPEELFEEVVPEELVAEVIPEEIVEEVIPEELIEEFVPEELVEEEVPE 8497
Query: 1213 GLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVIEGLEIVDDVVPKPSTTI 1034
L + + V E + EE + ++VI E+V++VVP+ +
Sbjct: 8498 ELVEEVIPEVLVEEVIPEEFVEEVIPEEIVEEVIPEEIVEEVIPE-EVVEEVVPEIVAEV 8556
Query: 1033 TGEEAIRNGQEENKVIEELEIVDAEEDIGEPIIE--KDVVPGHTTTIGEELINDVHDDNK 860
EE + E V+EE+ EE + E I E +VV + EE++ +V ++
Sbjct: 8557 IPEEVVEEVVPE--VVEEVVPEVIEEVVPEVIEEVVPEVVEEVVPEVVEEVVPEVVEEVV 8614
Query: 859 VIEGFEMVGSDKDTGEPV----VDDVIPEHSTTTSVGESIKDAHXXXXXXXXXXIVGADK 692
+E E V ++ E + ++++IPE V E ++D +
Sbjct: 8615 PVEVLEEVIPEEVVEEVIPEEFIEEMIPEEIVEEVVPEVVEDVIPEELIAEV-----VSE 8669
Query: 691 EIREPAIKEDVVPDLSTTTREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHS 512
E+ E I E++V + EE I + + E L ++ + ++ EE++ +
Sbjct: 8670 ELFEEEIPEELVEVVPVELLEEVIPEELVEEVIPEELVEEVVPEELVEEVVPEELVEE-- 8727
Query: 511 TTIIGEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAE 332
+I EE + E+ V V+ V++ I E +IE+ V EE +++ E
Sbjct: 8728 --VIPEELFEEVVPEELVEEVIPEEIVEEVIPEELIEEFVPEELVEEEVPEELVEEVIPE 8785
Query: 331 NKVIEGLEKVDLDKDIGEPITEKDVAPDNFIAAFEEEAIKDVHEEDKVIEETEIIGADKD 152
V E + + +++ I E + E+ + + F EE +++V E+ ++EE ++
Sbjct: 8786 VLVEEVIPEEFVEEVIPEELVEEVIPEELFEEVVPEELVEEVIPEE-IVEEVIPEELIEE 8844
Query: 151 IGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEELKIDGAKKDIGE 8
+ ++ EE++P+ + E I + E+ V EEL + ++I E
Sbjct: 8845 VVPEVLVEEVIPEE----LVEEVIPEELFEEVVPEELVAEVIPEEIVE 8888
Score = 125 bits (315), Expect = 8e-26
Identities = 222/1110 (20%), Positives = 478/1110 (43%), Gaps = 25/1110 (2%)
Frame = -1
Query: 3262 EVEESWSPDNTHSHLLDETSLKPIDLQKERNDENATEPKIQDT---KIMDIIGRVDIDDE 3092
E+ E P+ ++ E L+ + + +E +E E I + K+++ + ++ +E
Sbjct: 4795 ELVEELIPEEVVQEVITEEVLEEV-IPEEIVEELIPEKLIGEVVPEKVVEEVVLEEVVEE 4853
Query: 3091 EVPEQLEKD--------QPEMEQNDRKELPPEMKHEDLDFKGNGAQDVDGTPIEQINQGS 2936
+PE++ ++ + +E+ +EL EM E++ + +++ E + +
Sbjct: 4854 VIPEEIVEEVITEEVLAEEIVEEFVPEELVEEMLPEEVVEERVREVEIEEMVPEVLVEEV 4913
Query: 2935 KMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPEEEINEGLDIGGAE 2756
V EV +++ EE + + + E+ +E E PEE + E + E
Sbjct: 4914 LPEVVEEVITEEVVEEMVPEEVVEEMVPKEIVEEVLPEEVVEEVIPEEVVEEMVPEVLVE 4973
Query: 2755 EDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKDDGETVMEEDVVPD 2576
E E IVE V + + EE I++ E+ E++ V + E ++EE V +
Sbjct: 4974 EVVPEEIVEKVVPEEVVEEVVAEEIIEEVITEEVVEEIVPGEVVEEMVPEEIIEEVVPEE 5033
Query: 2575 PSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDVSTTTIGEAQTKDVR 2396
I EE ++ E+ V E+ SV+ +I E +++E V+P+ + E ++V
Sbjct: 5034 VIEEVITEEVVEEVIPEELVEEVIPEISVEVEIPEVLVEE-VIPEKLVKVVPEELVEEVI 5092
Query: 2395 EEDKIIEGLNIDADEEVGDSIT-KDVVQDQSTTTIGEETIKCGHEEERELXXXXXXXXXX 2219
E+ + E + EEV D + +++ ++ + EE I E E+
Sbjct: 5093 PEELVEEVITEALVEEVVDVVVPEEIFEEVLPEEVVEEVIP--EEVVEEMVPEEVVEEVV 5150
Query: 2218 XXXXXXXAVPATGEEPIKDGHEKEKIIEQPEIVGA-DREIREPVIEEDVVPDLSTTTTRE 2042
+P E + EK++ + + E+ E V+ E+++ ++ T E
Sbjct: 5151 PEELVEEVIPEEVVEKVVPEQLVEKVVPEELVEKVLPEELVEEVVPEELIEEVVTEEVIE 5210
Query: 2041 EPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVVPNHSITTIGEESTNDGQEEDKVVAE 1862
E I + ++IE + ++ + E+VP I + E + +K++ E
Sbjct: 5211 EIIPE-----EIIEEIIPEEVVEERVSIEVVEELVPEELIEEVVAEEIFEEVVPEKLIEE 5265
Query: 1861 LDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAENKVIEGLEKVDLDEHIGEHIT 1682
+ ++ + I EE I + E + E + + ++E I E +
Sbjct: 5266 VVAEELIEEMVPEVVEEVVEEIIPEEVI-EEVIPEEIREEIIPEEVVEEVIEEVIPEELI 5324
Query: 1681 EKDVAPDHSITSFEEEPIKDFHEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRG 1502
E++++ + EE +++ E+ + E ++ I + ++ EE++P+ +
Sbjct: 5325 EEEISREIVEEVIPEEVVEEMMPEEVIEEVIPEEIREEMIPEEVV-EEMIPEIEIEQVLP 5383
Query: 1501 EPIQDDHEEEKVIEELKIDGANKDIGESSIKDVVLDQSTTS--IGETPVKDAHEEHKVRV 1328
E + ++ E IEE+ + +++ + + V+ + I E +K+ E V
Sbjct: 5384 EELIEELVPEVEIEEILPEELIEELVPEGVIEEVIPKELIEEVIPEELIKEVVPEEVVEE 5443
Query: 1327 GANKDIGEPIIKENVVLDH-PTKTIGEIKDKHEEDKVI-EGLDNDCVNXXXXXXXXXXXG 1154
K+I E ++ E ++ + P + I E+ + ++VI E L + V
Sbjct: 5444 VIPKEIVEEVVPEELIEEVIPEELIEEVVPEEMIEEVIPEELIEEVV---------PEEM 5494
Query: 1153 VREHSTKTTWEEPTKDGHEDKVIEGLEIVDDVVPKPSTT-ITGEEAIRNGQEENKVIEEL 977
+ E + EE + +++VI +E++++VVP+ + EE + E V E L
Sbjct: 5495 IEEVIPEELIEEVVPEEVKEEVIP-VELIEEVVPEEMIEEVISEEVVEEVIPEELVEEVL 5553
Query: 976 EIVDAEEDIGEPIIEKDVVPGHTTTIGEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDD 797
V EE + + ++E +V+P EE++ +V + V E ++ E ++++
Sbjct: 5554 PEVFVEEIVPKELVE-EVIP-------EEIVEEVIPEELVEEVIPEELVEEVISEELLEE 5605
Query: 796 VIPEHSTTTSVGESIKDAHXXXXXXXXXXIVG--ADKEIREPAIKEDVVPDLSTTTREEP 623
VIPE V E I++ +V +E+ E I E+VV ++ E
Sbjct: 5606 VIPELLVEEVVPEVIEEVVPEVVEEVIPEVVEEVVTEELVEEVIPEEVVEEMIPGVEIEE 5665
Query: 622 IQDGHDINKV--GEGLEIAGSDKDNGDPIIE---EEVIPDHSTTIIGEESTNDGHEEDKV 458
+ + +V E +E S++D + I E EEVIP+ ++ EE + E+ +
Sbjct: 5666 VLPEELVEEVIPEEIVEEVISEEDFEEVIPEALVEEVIPE----LLVEEVVLEELIEEVI 5721
Query: 457 VAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGE 278
V++ V + +++ E VI + VV EE I + E + E + + + +++ E
Sbjct: 5722 PEVVEEV-IPEEVVEEVIPEEVVEKVVPEELVEEVIPEELVEEVIPEEVPEEVVPEELVE 5780
Query: 277 PITEKDVAPDNFIAAFEEEAIKDVHEEDKVIEETEIIGADKDIGDHIIGEEIVPDHSTTT 98
+ +++ + EE +++V E+ ++EE +++ + ++ EE+V +
Sbjct: 5781 EVISEELVEE----VIPEEIVEEVIPEE-IVEEV----MPEEVAEEVVPEELVEEEVPEE 5831
Query: 97 IRGEPIQDGHEEDKVTEELKIDGAKKDIGE 8
+ E I + E+ + EE+ + +++ E
Sbjct: 5832 LVEEVIPEVLVEEVIPEEIVEEVVPEEVVE 5861
Score = 124 bits (311), Expect = 2e-25
Identities = 243/1106 (21%), Positives = 476/1106 (43%), Gaps = 16/1106 (1%)
Frame = -1
Query: 3310 KEGVKMVTEETSLQK---SEVEESWSPDNTHSHLLDETSLKPIDLQKERNDENATEPKIQ 3140
KE V+ V E +++ EV E P+ ++ E ++ + + +E +E E I+
Sbjct: 4942 KEIVEEVLPEEVVEEVIPEEVVEEMVPEVLVEEVVPEEIVEKV-VPEEVVEEVVAEEIIE 5000
Query: 3139 DTKIMDIIGRV---DIDDEEVPEQL-EKDQPE------MEQNDRKELPPEMKHEDLDFKG 2990
+ +++ + ++ +E VPE++ E+ PE + + +E+ PE E++ +
Sbjct: 5001 EVITEEVVEEIVPGEVVEEMVPEEIIEEVVPEEVIEEVITEEVVEEVIPEELVEEVIPEI 5060
Query: 2989 NGAQDVDGTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNE 2810
+ ++ +E++ + V E +++ E + + E+ + +E E
Sbjct: 5061 SVEVEIPEVLVEEVIPEKLVKVVPEELVEEVIPEELVEEVITEALVEEVVDVVVPEEIFE 5120
Query: 2809 AKKPEEEINEGLDIGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIA 2630
PEE + E + EE E +VE V + I EE ++ E +V+
Sbjct: 5121 EVLPEEVVEEVIPEEVVEEMVPEEVVEEVVPEELVEEVIPEEVVEKVVPEQLVEKVVPEE 5180
Query: 2629 GVGKDDGETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIKENV 2450
V K E ++EE V + + EE ++ E+ + EI + V++ + +++E V
Sbjct: 5181 LVEKVLPEELVEEVVPEELIEEVVTEEVIEEIIPEEIIEEIIPEEVVEERVSIEVVEELV 5240
Query: 2449 VPDVSTTTIGEAQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCG 2270
++ + E ++V E I E + + EE+ + ++VV++ + EE I
Sbjct: 5241 PEELIEEVVAEEIFEEVVPEKLIEEVVAEELIEEMVPEVVEEVVEEIIPEEVIEEVIP-- 5298
Query: 2269 HEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQPEIVGADREIREPV 2090
EE RE +P E + + E++IE+ REI E V
Sbjct: 5299 -EEIRE-----------------EIIPEEVVEEVIEEVIPEELIEEE----ISREIVEEV 5336
Query: 2089 IEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGE-VVPNHSITTI 1913
I E+VV ++ EE I + +I + + E+ + P IE E V+P I
Sbjct: 5337 IPEEVVEEMMPEEVIEEVIPE--EIREEMIPEEVV----EEMIPEIEIEQVLPEELI--- 5387
Query: 1912 GEESTNDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAENKVI 1733
EE + + E+ + EL + + + I EE I++ E V
Sbjct: 5388 -EELVPEVEIEEILPEEL----IEELVPEGVIEEVIPKELIEEVIPEELIKEVVPEEVVE 5442
Query: 1732 EGLEKVDLDEHIGEHITEKDVAPDHSITSFEEEPIKDFHEEDKVIEGTEIVGADKDIGDP 1553
E + K ++E + E + E +V P+ I E + + +++IE E+V +++ +
Sbjct: 5443 EVIPKEIVEEVVPEELIE-EVIPEELIEEVVPEEMIEEVIPEELIE--EVV--PEEMIEE 5497
Query: 1552 IIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGANKDIGESSIKDVVLDQSTTSIG 1373
+I EE++ + ++ E I + EE V EE+ + ++++ E I + ++++ +
Sbjct: 5498 VIPEELIEEVVPEEVKEEVIPVELIEEVVPEEMIEEVISEEVVEEVIPEELVEE---VLP 5554
Query: 1372 ETPVKDAHEEHKVRVGANKDIGEPIIKENVVLD-HPTKTIGEIKDKHEEDKVIEGLDNDC 1196
E V++ + V ++I E +I E +V + P + + E+ + ++VI L
Sbjct: 5555 EVFVEEIVPKELVEEVIPEEIVEEVIPEELVEEVIPEELVEEVISEELLEEVIPEL---- 5610
Query: 1195 VNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVIEGLEIVDDVVPKPSTTITGEEAI 1016
V E EE + E+ V E E+V++V+P+ EE I
Sbjct: 5611 ------LVEEVVPEVIEEVVPEVVEEVIPEVVEEVVTE--ELVEEVIPEEVV----EEMI 5658
Query: 1015 RNGQEENKVIEEL-EIVDAEEDIGEPIIEKDVVPGHTTTIGEELINDVHDDNKVIEGFEM 839
+ E + EEL E V EE + E I E+D + EE+I ++ + V+E E+
Sbjct: 5659 PGVEIEEVLPEELVEEVIPEEIVEEVISEEDFEEVIPEALVEEVIPELLVEEVVLE--EL 5716
Query: 838 VGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAHXXXXXXXXXXIVGADKEIREPAIKEDV 659
+ ++ VV++VIPE + E + + +E+ + E+V
Sbjct: 5717 I---EEVIPEVVEEVIPEEVVEEVIPEEVVEKVVPEELVEEVIPEELVEEVIPEEVPEEV 5773
Query: 658 VPDLSTTTREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHSTTIIGEESTND 479
VP EE +++ V E + ++ + I+EE + + + ++ EE +
Sbjct: 5774 VP-------EELVEEVISEELVEEVIPEEIVEEVIPEEIVEEVMPEEVAEEVVPEELVEE 5826
Query: 478 GHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVD 299
E+ V V+ V V++ I E ++E+ V EE I++ E V+E +
Sbjct: 5827 EVPEELVEEVIPEVLVEEVIPEEIVEEVVPEEVVEVVIPEEFIEEIIPEEVVVEVTPEEL 5886
Query: 298 LDKDIGEPITEKDVAPDNFIAAFEEEAIKDVHEEDKVIEETEIIGADKDIGDHIIGEEIV 119
+++ E + E+ + + EE IK+V E+ +IEE K+I + ++ EEI+
Sbjct: 5887 IEEMKPEELFEEVIPKELIEEIIPEELIKEVIPEE-IIEEV----ISKEIVEEVVEEEII 5941
Query: 118 PDHSTTTIRGEPIQDGHEEDKVTEEL 41
+ I E + + E KV EE+
Sbjct: 5942 EEVIPEEIVEEVVPEELVEKKVPEEI 5967
Score = 123 bits (308), Expect = 5e-25
Identities = 231/1103 (20%), Positives = 476/1103 (43%), Gaps = 29/1103 (2%)
Frame = -1
Query: 3262 EVEESWSPDNTHSHLLDETSLK---PIDLQKERNDENATEPKIQDTKIMDIIGRVDIDDE 3092
E+ E P+ ++ E ++ P +L ++ E E I + + +++ ++ +E
Sbjct: 6667 ELVEEVVPEELVEEVIPEELVEEVVPEELVEKLIPEELVEEVIPELLVEEVVPE-EVVEE 6725
Query: 3091 EVPEQL-EKDQPE--MEQNDRKELPPEMKHEDLDFKGNGAQDVDGTPIEQINQG---SKM 2930
+PE+L E+ PE +E+ +E+P E+ E+L + + V+ E++ + ++
Sbjct: 6726 LIPEELVEEVIPEELVEEVIPEEVPEEVIREELVEEVIPEELVEEVIPEEVPEEVVPEEL 6785
Query: 2929 VQ-------VTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPEEEINEGLD 2771
VQ V EV H+++ EE K + + EL +E E PEE + E +
Sbjct: 6786 VQEVIPEELVEEVVHEEVPEEVVPEKLVEEVIPEELFEEVVPEEVPEEVVPEELVEEVIS 6845
Query: 2770 IGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVL--EIAG--VGKDDGET 2603
EE E +VE + + I EE +++ E+ E + E+ + ++ E
Sbjct: 6846 EELVEEVIPEELVEEFIPEELVEEVIPEELVEEVIPEELVEEFIPEELVEEVIPEELVEE 6905
Query: 2602 VMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDVSTTTI 2423
V+ E +V + + EE + E+ + E+ + V +++ E ++ E +V +V +
Sbjct: 6906 VIPEVLVEEEIPEKLVEEVVPEELVEEVIPEVLVEEVVTEEVPEEVVPEELVAEV----V 6961
Query: 2422 GEAQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCGHEEERELXX 2243
E K+V E+ + E + + EEV I ++VV++ + EE I E E+
Sbjct: 6962 PEELVKEVIPEELVEEVIPEEIVEEV---IPEEVVEEVVPEELVEEVIP--EEVVEEVIP 7016
Query: 2242 XXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQPEIVGADREIREPVIEEDVVPDL 2063
VP E + E++I + EIV + I E V+EE + ++
Sbjct: 7017 EELVEEVVPVELVEEVVPEELVEEVIPEELVEEVIPE-EIV--EEVIPEEVVEEVIPEEI 7073
Query: 2062 STTTTREEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVVPNHSITTIGEESTNDGQE 1883
EE I++ + + E + + + +E EV+P I + E +
Sbjct: 7074 VEEVISEELIEEVVPVELLEEVVPVEVLEDVIPEEVVE-EVIPEEFIEEMIPEEIIEEAI 7132
Query: 1882 EDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAENKVIEGLEKVDLDE 1703
+++V E+ V + + + EE +++ E V E + + +E
Sbjct: 7133 PEEIVEEVIPEVVEEVVPEELVEEVIPEEVVEKVVPEELVEEVIPEELVEEVIPEEVPEE 7192
Query: 1702 HIGEHITEKDVAPDHSITSFEEEPIKDFHEEDKVIEGTEIVGADKDIGDPIIGEEIVPDH 1523
+ E + E+ ++ + EE +++ E+ V E ++ I + ++ EE++P+
Sbjct: 7193 VVPEELVEEVISEELVEEIIPEELVEEVIPEEVVEEVVPEELVEEVIPEELV-EEVIPEE 7251
Query: 1522 STTTIRGEPIQDDHEEEKVIEELKIDGANKDIGESSIKDVVLDQSTTSIGETPVKDAHEE 1343
+ E +++ E+ V E + + + I E +++VV + I E +++ E
Sbjct: 7252 LVEEVIPEVVEEVIPEKLVEEVVPEELIEEMIPEEIVEEVVPEVVEEVIPEELIEEVIPE 7311
Query: 1342 HKVRVGANKDIGEPIIKENVVLDHPTKTIGE--IKDKHEEDKVIEGLDNDCVNXXXXXXX 1169
V + + E +I E +V + + + E I ++ E+ + E L + V
Sbjct: 7312 ELVEEVIPEKLIEEMIPEELVEEVILEEVVEEVIPEEVVEEVLPEELVEEVVPEELVEEV 7371
Query: 1168 XXXXGVREHSTKTTWEEPTKDGHEDKVIEGLEIVDDVVPKPST-TITGEEAIRNGQEENK 992
+ E + EE + ++VI E+V+DV+P+ + EE + E
Sbjct: 7372 APVELLEEVIPEELLEEVIPEELVEEVIPE-ELVEDVIPEELVEEVIPEELVEEIIPEEL 7430
Query: 991 VIEELEIVDAEEDIGEPIIEKDVVPGHTTTIGEELINDVHDDNKVIEGFEMVGSDKDTGE 812
V E + V EE++ E ++E +V+P EEL+ +V + V E V ++ E
Sbjct: 7431 VEEVIPEVLVEEEVPEELVE-EVIP-------EELVEEVIPEELVEELIPEV-LEEVIPE 7481
Query: 811 PVVDDVIPEHSTTTSVGESIKDAHXXXXXXXXXXIVGADKEIREPAIKEDVVPD--LSTT 638
+V++V+P + E + + ++ I E +KE VVP+ +
Sbjct: 7482 KLVEEVVPVELLEEVIPEELIEEVVPEVLVEVIPEKVVEEVIHEEIVKE-VVPEELVEEV 7540
Query: 637 TREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHSTTIIGEESTNDGHEEDKV 458
EE +++ + E + +++ + ++EE + + ++ EE + E+ V
Sbjct: 7541 VPEEIVEEVVPEEVLEEVIPKVLLEEEIPEKLVEEVIPEELIEEVVPEELVEEVMPEEVV 7600
Query: 457 VAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKV-IEGLEKVDLDKDIG 281
V+ V++ I E V+E+ V+P EE + E V +E LE+V ++ +
Sbjct: 7601 EEVVPEELVEEVIPEEVVEE-VIPEELV----EEVVPVELLEEIVPVELLEEVIPEELVE 7655
Query: 280 EPITE---KDVAPDNFIAAFEEEAIKDVHEEDKVIEETEIIGADKDIGDHIIGEEIVPDH 110
E I E ++V P+ +A E + + +K++EE +++ + ++ EE+V +
Sbjct: 7656 EVIPEELVEEVVPEELVAEVIPEKLVEEVIPEKLVEEV----IPEELVEEVVPEELVAEV 7711
Query: 109 STTTIRGEPIQDGHEEDKVTEEL 41
+ E I + E+ + EEL
Sbjct: 7712 IPEKLVEEVIPEELVEEIIPEEL 7734
Score = 121 bits (304), Expect = 1e-24
Identities = 235/1103 (21%), Positives = 467/1103 (42%), Gaps = 29/1103 (2%)
Frame = -1
Query: 3262 EVEESWSPDNTHSHLLDETSLKPI--DLQKERNDENATEPKIQDTKIMDIIGRVDIDDEE 3089
EV E P+ ++ E ++ + ++ +E E E I + + +++ V ++ E
Sbjct: 1576 EVVEELVPEELVEEVIPEEIVEEVVEEVVEEIIPEEVIEEVIPEEIVKEVVPEVLVE-EV 1634
Query: 3088 VPEQL-EKDQPE--MEQNDRKELPPEMKHEDLDFKGNGAQDVDGTPIEQINQGSKMVQVT 2918
VPE++ E+ PE +E+ +EL E+ E+L ++V P E + + V V
Sbjct: 1635 VPEEIVEEVVPEEIVEEVVPEELVEEVVPEEL------IEEV--IPEELVEEVIPEVLVE 1686
Query: 2917 EVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPEEEINEGLDIGGAEEDTGEH 2738
EV + + EE ++L E+ E E+ K EE+ EE E
Sbjct: 1687 EVIPEVLVEEMV-LEELVEEVIPEVLVEEMVPEEVVEKMVLEEV--------VEEVIPEE 1737
Query: 2737 IVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKDDGETVMEEDVVPDPSTTTI 2558
+VE + + I EE I++ E+ EV+ V + E ++E+ V + I
Sbjct: 1738 VVEEVIPEEDVEQVIPEELIEEVVPEEVIEEVITEEVVEEVLPEELVEKVVEEEILEEVI 1797
Query: 2557 GEEPTKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDVSTTTIGEAQTKDVREEDKII 2378
EE ++ E+ + E+ + V+K + E I++E V+ +V I + ++V E+ +
Sbjct: 1798 PEELVEEVVREELIEEVVTEELVEKVVEEEIVEEVVLAEVVEEVIPQEIVEEVIPEEVVE 1857
Query: 2377 EGLNIDADEEV-GDSITKDVVQDQSTTTIGEETIKCGHEEERELXXXXXXXXXXXXXXXX 2201
E + + EEV + + ++VV ++ + E + E EL
Sbjct: 1858 EVIPKEIVEEVIPEELVEEVVPEELVAEVIPEELVAEVIPE-ELIEEVVTEELVEEVIPE 1916
Query: 2200 XAVPATGEEPIKDGHEKEKIIEQPEIVGADREIREPVIEEDVVPDLSTTTTREEPIQDGH 2021
V E + + E+++E E+V E+ E V+ E++V +L EE I +
Sbjct: 1917 EVVEEVIPEEVVEEVVPEELVE--EVV--PEELVEEVVPEEIVEELLPKEVVEEVIYE-E 1971
Query: 2020 DINKVIEGLEIASSNKDNGDPTIEGEVVPNHSITTIGEESTNDGQEEDKVVAEL--DIVD 1847
+ +VI +A EV+P + + E + +++V E+ ++V+
Sbjct: 1972 QVEEVIPEELVA-------------EVIPEKLVEEVIPEELVEEVIPEELVEEVVPEVVE 2018
Query: 1846 VHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAENKVIEGLEKVDLDEHIGEHITEKDVA 1667
+ EE +++ E V E + +V ++E + E + E +V
Sbjct: 2019 --------------------EVVPEELVEEVIPEELVEEVIPEVLVEEEVPEELVE-EVI 2057
Query: 1666 PDHSITSFEEEPIKDFHEEDKVIEGTEIVGAD-------KDIGDPIIGEEIVPDHSTTTI 1508
P+ + E + + ++++E E+V + +++ + +I EE++ +
Sbjct: 2058 PEELVEEMLPEELIEVVVPEELVE--EVVPEELVEEVVPEEVVEEVIPEELIEELVPEVE 2115
Query: 1507 RGEPIQDDHEEEKVIEELKIDGANKDIGESSIKDVVLDQSTTSIGETPVKDAHEE---HK 1337
E + ++ EE V EE+ + K++ E I +VV+++ + E V + EE
Sbjct: 2116 IEEILPEELIEELVPEEIIEEVIPKELIEEVIPEVVVEEVVPEVVEEVVPEIVEEVVPEV 2175
Query: 1336 VRVGANKDIGEPIIKENVVLDHPTKTIGE--IKDKHEEDKVIEGLDNDCVNXXXXXXXXX 1163
V ++I E I E VV + K I E I ++ E+ V E L + +
Sbjct: 2176 VEEVVPEEIIEEKISEEVVEEVLPKEIVEEVIPEELVEEVVPEELVAEVIPEELVEEVIP 2235
Query: 1162 XXGVREHSTKTTWEEPTKDGHEDKVIEGLEIVDDVVPKPSTTITGEEAIRNGQEENKVIE 983
E + EE + E+++ E +V++VVP+ + EE + E + E
Sbjct: 2236 EVLFEEEIPEVVVEEVVPEVVEEEIPE--VVVEEVVPEVVEEVIPEELVEEVIPEELIEE 2293
Query: 982 ELEIVDAEEDIGEPIIEKDVVPGHTT--TIGEELINDVHDDNKVIEGFEMVGSDKDTGEP 809
+ AEE + E +IE +V+P + EEL+ +V + V E ++ E
Sbjct: 2294 VIPEEVAEEVLPEELIE-EVIPEELVEEVVPEELVAEVIPEEIVEEVVREELVEEVVPEE 2352
Query: 808 VVDDVIPEHSTTTSVGESIKDAHXXXXXXXXXXIVGADKEIREPAIKEDVVPDLSTTTRE 629
VV++VIP+ V E + + KEI E + E++V + E
Sbjct: 2353 VVEEVIPKEIVEEVVSEEVVEE-------------VIPKEIVEEEVPEELVEVVPEELVE 2399
Query: 628 EPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHSTTIIGEESTNDGHEEDKVVAV 449
E + + V E L ++ + ++ EE++ + ++ E +E V
Sbjct: 2400 EVVPEELVEEVVPEELVEEVVPEELVEEVVPEELVEEVVPEVVEEV------QEQLVEEF 2453
Query: 448 LDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPIT 269
+ V++ + E ++E+ + EE +++ E V E + + +++ I E +
Sbjct: 2454 IPEEVVEELVPEELVEEVIPEELVEEVIPEEIVEEVLPEEVVKEVIPEEVVEEVIPEELV 2513
Query: 268 EKDVAPDNFIAAFEEEAIKDVHEEDKVIEET-------EIIGADKDIGDHIIGEEIVPDH 110
E+ + + EE +K+V E+ V+EE E+I +++ + +I EE+V +
Sbjct: 2514 EEVIPEEIVEEVLPEEVVKEVIPEE-VVEEVIPEELVEEVI--PEELVEEVIPEELVEEV 2570
Query: 109 STTTIRGEPIQDGHEEDKVTEEL 41
+ + E I + E+ + EEL
Sbjct: 2571 VSEELVEEVIPEEIVEEVIPEEL 2593
Score = 120 bits (302), Expect = 3e-24
Identities = 235/1125 (20%), Positives = 468/1125 (41%), Gaps = 24/1125 (2%)
Frame = -1
Query: 3310 KEGVKMVTEETSLQK---SEVEESWSPDNTHSHLLDETSLK---PIDLQKERNDENATEP 3149
+E VK V E +++ E+ E P+ ++ E ++ P +L +E E E
Sbjct: 1619 EEIVKEVVPEVLVEEVVPEEIVEEVVPEEIVEEVVPEELVEEVVPEELIEEVIPEELVEE 1678
Query: 3148 KIQDTKIMDIIGRVDIDDEEVPEQLEKDQPEMEQNDRKELPPEMKHEDLDFKGNGAQDVD 2969
I + + ++I V +++ + E +E+ PE+ L EM E++ V+
Sbjct: 1679 VIPEVLVEEVIPEVLVEEMVLEELVEEVIPEV-------LVEEMVPEEV---------VE 1722
Query: 2968 GTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPEEE 2789
+E++ V EV +++ EE +D+ + EL E PEE
Sbjct: 1723 KMVLEEV--------VEEVIPEEVVEEVIPEEDVEQVIPEELI---------EEVVPEEV 1765
Query: 2788 INEGLDIGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKDDG 2609
I E + EE E +VE V + I EE +++ +E+ EV+ V K
Sbjct: 1766 IEEVITEEVVEEVLPEELVEKVVEEEILEEVIPEELVEEVVREELIEEVVTEELVEKVVE 1825
Query: 2608 ETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDVSTT 2429
E ++EE V+ + I +E ++ E+ V E+ + K+I E +I E +V +V
Sbjct: 1826 EEIVEEVVLAEVVEEVIPQEIVEEVIPEEVVEEV-----IPKEIVEEVIPEELVEEV--- 1877
Query: 2428 TIGEAQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCGHEEEREL 2249
+ E +V E+ + E + + EEV +T+++V++ + EE I
Sbjct: 1878 -VPEELVAEVIPEELVAEVIPEELIEEV---VTEELVEEVIPEEVVEEVIP--------- 1924
Query: 2248 XXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQPEIVGADREIREPVIEEDVVP 2069
E + + E+++E E+V E+ E V+ E++V
Sbjct: 1925 ------------------------EEVVEEVVPEELVE--EVV--PEELVEEVVPEEIVE 1956
Query: 2068 DLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVVPNHSITTIGEESTNDG 1889
+L EE I + + +VI +A EV+P + + E +
Sbjct: 1957 ELLPKEVVEEVIYE-EQVEEVIPEELVA-------------EVIPEKLVEEVIPEELVEE 2002
Query: 1888 QEEDKVVAEL--DIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAENKVIEGLEKV 1715
+++V E+ ++V+ + EE +++ E V E + +V
Sbjct: 2003 VIPEELVEEVVPEVVE--------------------EVVPEELVEEVIPEELVEEVIPEV 2042
Query: 1714 DLDEHIGEHITEKDVAPDHSITSFEEEPIKDFHEEDKVIEGTEIVGAD-------KDIGD 1556
++E + E + E +V P+ + E + + ++++E E+V + +++ +
Sbjct: 2043 LVEEEVPEELVE-EVIPEELVEEMLPEELIEVVVPEELVE--EVVPEELVEEVVPEEVVE 2099
Query: 1555 PIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGANKDIGESSIKDVVLDQSTTSI 1376
+I EE++ + E + ++ EE V EE+ + K++ E I +VV+++ +
Sbjct: 2100 EVIPEELIEELVPEVEIEEILPEELIEELVPEEIIEEVIPKELIEEVIPEVVVEEVVPEV 2159
Query: 1375 GETPVKDAHEE---HKVRVGANKDIGEPIIKENVVLDHPTKTIGE--IKDKHEEDKVIEG 1211
E V + EE V ++I E I E VV + K I E I ++ E+ V E
Sbjct: 2160 VEEVVPEIVEEVVPEVVEEVVPEEIIEEKISEEVVEEVLPKEIVEEVIPEELVEEVVPEE 2219
Query: 1210 LDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVIEGLEIVDDVVPKPSTTIT 1031
L + + E + EE + E+++ E +V++VVP+ +
Sbjct: 2220 LVAEVIPEELVEEVIPEVLFEEEIPEVVVEEVVPEVVEEEIPE--VVVEEVVPEVVEEVI 2277
Query: 1030 GEEAIRNGQEENKVIEELEIVDAEEDIGEPIIEKDVVPGHTT--TIGEELINDVHDDNKV 857
EE + E + E + AEE + E +IE +V+P + EEL+ +V + V
Sbjct: 2278 PEELVEEVIPEELIEEVIPEEVAEEVLPEELIE-EVIPEELVEEVVPEELVAEVIPEEIV 2336
Query: 856 IEGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAHXXXXXXXXXXIVGADKEIREP 677
E ++ E VV++VIP+ V E + ++ I +
Sbjct: 2337 EEVVREELVEEVVPEEVVEEVIPKEIVEEVVSEEV-----------------VEEVIPKE 2379
Query: 676 AIKEDVVPDLSTTTREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHSTT-II 500
++E+V +L EE ++ E+ + + EEV+P+ ++
Sbjct: 2380 IVEEEVPEELVEVVPEELVE------------EVVPEE-------LVEEVVPEELVEEVV 2420
Query: 499 GEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVI 320
EE + E+ V V + V +++ E ++E+ + EE +++ E V
Sbjct: 2421 PEELVEEVVPEELVEEV--VPEVVEEVQEQLVEEFIPEEVVEELVPEELVEEVIPEELVE 2478
Query: 319 EGLEKVDLDKDIGEPITEKDVAPDNFIA-AFEEEAIKDVHEEDKVIEETEIIGADKDIGD 143
E + + +++ + E + K+V P+ + EE +++V E+ ++EE +++
Sbjct: 2479 EVIPEEIVEEVLPEEVV-KEVIPEEVVEEVIPEELVEEVIPEE-IVEEV----LPEEVVK 2532
Query: 142 HIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEELKIDGAKKDIGE 8
+I EE+V + + E I + E+ + EEL + +++ E
Sbjct: 2533 EVIPEEVVEEVIPEELVEEVIPEELVEEVIPEELVEEVVSEELVE 2577
Score = 120 bits (302), Expect = 3e-24
Identities = 237/1104 (21%), Positives = 468/1104 (42%), Gaps = 26/1104 (2%)
Frame = -1
Query: 3274 LQKSEVEESWSPDNTHSHLLDETSLKPIDLQKERNDENATEPKIQDTKIMDIIGRVDIDD 3095
L + EV E D L++E + P +L +E E E + + + +++ +I +
Sbjct: 7905 LVEEEVPEELVEDVIPEELVEE--VVPEELVEEVIPEEVVEEVLPEELVEEVVPE-EIVE 7961
Query: 3094 EEVPEQL-EKDQPE--MEQNDRKELPPEMKHEDLDFKGNGAQDVDGT-PIEQINQGSKMV 2927
E +PE+L E++ PE +E+ +E+ E+ E++ K + V+ P E + +
Sbjct: 7962 EVIPEELVEEEVPEELVEEVIPEEVVEEVIPEEVPEKVIPEKLVEELIPEEVVEELIPEE 8021
Query: 2926 QVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPEEEINEGLDIGGAEEDT 2747
V E+ ++ EE + L + + +E E PEE + E + EE
Sbjct: 8022 VVEEMVPIEVVEEVVPTEVLEEVIPEIVVEEVVPEELVEEVIPEELVEEVIPEIVVEEVV 8081
Query: 2746 GEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVL--EIAG--VGKDDGETVMEEDVVP 2579
E +VE + + + EE +++ E+ E+L EI + ++ E V+ E++V
Sbjct: 8082 PEELVEEVIPEELVEEVVPEELVEEVVPEEIVEELLPKEIVEEVIYEEQVEEVIHEELVA 8141
Query: 2578 DPSTTTIGEEPTKDGHEE---DKVIEISKIDSVDKDIGESIIKENVVPDVSTTTIGEAQT 2408
+ + EE + EE + V E+ + V++ + E + E VVP+V I E
Sbjct: 8142 EVIPEEVVEEVVPEVVEEVVPEIVAEVIPEEVVEEVVPEVV--EEVVPEVVEEVIPEEVV 8199
Query: 2407 KDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCGHEEERELXXXXXXX 2228
++V E+ I E + + EEV + ++V+ ++ + E E E+
Sbjct: 8200 EEVIPEEFIEEMIPEEIVEEVVPEVVEEVIPEELVAEVIPE------ELVEEVIPEVLFE 8253
Query: 2227 XXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQPEIVGADREIREPVIEEDVVPDLSTTTT 2048
VP EE I + +E + PE+V E VI E+VV +L
Sbjct: 8254 EEIPEVVVEEVVPEVVEEEIPEVVVEEVV---PEVV-------EEVIPEEVVEELIPEEV 8303
Query: 2047 REEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVVPNHSITTIGEESTNDGQEEDKVV 1868
EE + +++E + ++ + EVVP + + E + +++V
Sbjct: 8304 VEEMVPI-----EIVEEVVPTEVLEEVIPEIVVEEVVPEELVEEVIPEELVEEVVPEELV 8358
Query: 1867 AELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAENKVIEGLEKVDLDEHIGEH 1688
E+ + +V + + I E +++ E V E + + ++E I E
Sbjct: 8359 EEV-VPEVVEEVVPEVVEEVVPEELVEEVIPEVVVEEVVPEELVEEVIPEELVEEIIPEE 8417
Query: 1687 ITEKDVAPDHSITSFEEEPIKDFHEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTI 1508
I E +V P+ I E + + ++++E E++ +++ + ++ EE+V + I
Sbjct: 8418 IVE-EVIPEELIEEVVPEVLVEEVIPEELVE--EVI--PEELFEEVVPEELVAEVIPEEI 8472
Query: 1507 RGEPIQDDHEEEKVIEELKIDGANKDIGESSIKDVVLDQSTTSIGETPVKDAHEEHKVRV 1328
E I ++ EE V EEL + +++ E I +V++++ I E V++ E V
Sbjct: 8473 VEEVIPEELIEEFVPEELVEEEVPEELVEEVIPEVLVEEV---IPEEFVEEVIPEEIVEE 8529
Query: 1327 GANKDIGEPIIKENVVLDHPTKTIGEIKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVR 1148
++I E +I E VV + + + E+ + ++V+ + + V V
Sbjct: 8530 VIPEEIVEEVIPEEVVEEVVPEIVAEVIPEEVVEEVVPEVVEEVV-----------PEVI 8578
Query: 1147 EHSTKTTWEEPTKDGHEDKVIEGLEIVDDVVPKPSTTITGEEAIRNGQEENKVIEELEIV 968
E EE + E+ V E +V++VVP+ + E + E V E +
Sbjct: 8579 EEVVPEVIEEVVPEVVEEVVPE---VVEEVVPEVVEEVVPVEVLEEVIPEEVVEEVIPEE 8635
Query: 967 DAEEDIGEPIIEKDVVPGHTTTIGEELINDVHDDN--------KVIEGFEMVGSDKDTGE 812
EE I E I+E+ V I EELI +V + +++E + ++ E
Sbjct: 8636 FIEEMIPEEIVEEVVPEVVEDVIPEELIAEVVSEELFEEEIPEELVEVVPVELLEEVIPE 8695
Query: 811 PVVDDVIPEHSTTTSVGESIKDAHXXXXXXXXXXIVGADKEIREPAIKEDVVPD--LSTT 638
+V++VIPE V E + + E+ + E+V+P+
Sbjct: 8696 ELVEEVIPEELVEEVVPEELVE------------------EVVPEELVEEVIPEELFEEV 8737
Query: 637 TREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHSTTIIGEESTNDGHEEDKV 458
EE +++ V E + ++ + ++EEEV + +I E + E+ V
Sbjct: 8738 VPEELVEEVIPEEIVEEVIPEELIEEFVPEELVEEEVPEELVEEVIPEVLVEEVIPEEFV 8797
Query: 457 VAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGE 278
V+ V++ I E + E+ V EE +++ E + E + +V +++ I E
Sbjct: 8798 EEVIPEELVEEVIPEELFEEVVPEELVEEVIPEEIVEEVIPEELIEEVVPEVLVEEVIPE 8857
Query: 277 PITEKDVAPDNFIAAFEEEAIKDVHEEDKVIEET---EIIG--ADKDIGDHIIGEEIVPD 113
+ E+ + + F EE + +V E+ ++EE E+I +++ + + EE+V +
Sbjct: 8858 ELVEEVIPEELFEEVVPEELVAEVIPEE-IVEEVIPEELIEEFVPEELVEEEVPEELVEE 8916
Query: 112 HSTTTIRGEPIQDGHEEDKVTEEL 41
+ E + + E+ + EEL
Sbjct: 8917 VIPEVLVEEEVPEELVEEVIPEEL 8940
Score = 115 bits (289), Expect = 8e-23
Identities = 247/1171 (21%), Positives = 479/1171 (40%), Gaps = 74/1171 (6%)
Frame = -1
Query: 3298 KMVTEET--SLQKSEVEESWSPDNTHSHLLDETSLK---PIDLQKERNDENATEPKIQDT 3134
++VTEE + EV E P +L E ++ P ++ +E E E I +
Sbjct: 5638 EVVTEELVEEVIPEEVVEEMIPGVEIEEVLPEELVEEVIPEEIVEEVISEEDFEEVIPEA 5697
Query: 3133 KIMDIIGRVDIDDEEVPEQLEKDQPEM-EQNDRKELPPEMKHEDLDFKGNGAQDVDGTPI 2957
+ ++I + +++ + E +E+ PE+ E+ +E+ E+ E++ K P
Sbjct: 5698 LVEEVIPELLVEEVVLEELIEEVIPEVVEEVIPEEVVEEVIPEEVVEKV--------VPE 5749
Query: 2956 EQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPEEEINEG 2777
E + + V EV +++ EE + + + + EL +E E PEE + E
Sbjct: 5750 ELVEEVIPEELVEEVIPEEVPEEVVPEELVEEVISEELVEEVIPEEIVEEVIPEEIVEEV 5809
Query: 2776 LDIGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKDDGETVM 2597
+ AEE E +VE +V + I E +++ E+ EV+ V E +
Sbjct: 5810 MPEEVAEEVVPEELVEEEVPEELVEEVIPEVLVEEVIPEEIVEEVVPEEVVEVVIPEEFI 5869
Query: 2596 EEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDVSTTTIGE 2417
EE + + EE ++ E+ E+ + +++ I E +IKE + ++ I +
Sbjct: 5870 EEIIPEEVVVEVTPEELIEEMKPEELFEEVIPKELIEEIIPEELIKEVIPEEIIEEVISK 5929
Query: 2416 AQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCGHEEE---RELX 2246
++V EE+ I E + + EEV + +++V+ + I EE I EE EL
Sbjct: 5930 EIVEEVVEEEIIEEVIPEEIVEEV---VPEELVEKKVPEEIVEEVIYEEFLEEIMPEELI 5986
Query: 2245 XXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQPEIVGADREIREPVIEEDVVPD 2066
V E + + + E+++E+ E+ E ++ E+VV +
Sbjct: 5987 EEMKPEELIEEIIPREIVEEIITEEVVEEMKPEELVEEM----VPEEVVEEMVPEEVVEE 6042
Query: 2065 LSTTTTREEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVVPNHSITT-IGEESTNDG 1889
+ EE I + K+IE + ++ + EV+P I I EE +
Sbjct: 6043 MVPEEVVEEVITE-----KLIEEVVPEEIIEELIPEELVEEVIPEKLIEEMIPEEVVEEM 6097
Query: 1888 QEED---KVVAELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAENKVIEGL-E 1721
E+ +VV E++I ++ + + EE I + E V E + E
Sbjct: 6098 LLEEVVEEVVPEVEIEEMIPEQLVEEVVPEELVEKEIPEVVEEIITEEVVEEMVPEEVVE 6157
Query: 1720 KVDLDEHIGEHITEK---DVAPDHSITSFEEEPIKDFHEEDKVIEGTEIVGADKDIGDPI 1550
++ +E + E I EK +V P I E + + +K+IE +I +
Sbjct: 6158 EMVPEEVVEEVILEKLIEEVVPVEVIEEVVPEEVIEEVIPEKLIE---------EIIPEV 6208
Query: 1549 IGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGANKDIGESSIKDVVLDQSTTSIGE 1370
+ EE+VP+ + E + ++ E V E + + K + E +++V+ + I E
Sbjct: 6209 LVEEVVPEELIEEVIPEVLFEEVVPEVVEEVVPEELVEKVVPEEIVEEVIPEFVEEVISE 6268
Query: 1369 TPVKDAHEEHKVRVGANKDIGEPIIKENVVLDH-PTKTIGEIKDKHEEDKVI-EGLDNDC 1196
V++ E + +++ E +I E +V + P + I E+ ++VI E L +
Sbjct: 6269 EIVEEVVTEELIEEMIPEEVVEEVIPEELVEEVVPVELIEEVVPVELLEEVIPEELVEEV 6328
Query: 1195 VNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVIEGLE-------------IVDDVV 1055
V + E + EE + ++ V E +E +V++VV
Sbjct: 6329 VPVELIEEVVPVELLEEVIPEEVVEEVIPEVVKEVVPEVVEEVVPEVVEEVVPEVVEEVV 6388
Query: 1054 PKPSTTITGEEAIRNGQEEN--------KVIEELEIVDAEEDIGEPIIEKDVVPGHTTT- 902
P+ + EE I E +VIEEL+ + E+I + ++V+P
Sbjct: 6389 PEVVEEVVPEELIEEVIPEELIKEVLPEEVIEELKPEELIEEIIPEEVVEEVIPEELIEE 6448
Query: 901 -IGEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAHXXXXX 725
I E L+ + + V E V ++ E +V++VIPE E + +
Sbjct: 6449 MIPELLVEEEVPEELVEEVIPEVLVEEMVPEEIVEEVIPEELIAEFAPEELFEKVIPEEV 6508
Query: 724 XXXXXIVGADKEIRE-------PAIKEDVVPD-----------LSTTTREEPIQDGHDIN 599
+E+ P + E+V+P+ + +E I++
Sbjct: 6509 VEELVSEELVEEVLPEVVEEVLPEVFEEVIPEEVIEEIVPEEVMEEVVPKELIEEVIPEE 6568
Query: 598 KVGEGLEIAGSDKDNGDPIIEE--------EVIPDHSTT-IIGEESTNDGHEEDKVVAVL 446
+ E + +++ + +IEE EV+P+ +I EE + E+ V V+
Sbjct: 6569 LIEEVIPEEVAEEVVPEKLIEEVIPEELIKEVVPEELIEEVITEEVVEEAISEELVEEVV 6628
Query: 445 DIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPITE 266
V++ I E +IE+ V EE +++ E V E + + +++ I E + E
Sbjct: 6629 PEEVVEEVIPEELIEEVVPEELIEEIIPEELVEEVIPEELVEEVVPEELVEEVIPEELVE 6688
Query: 265 KDVAPDNFIAAF-----EEEAIKDVHEEDKVIEETEIIGADKDIGDHIIGEEIVPDHSTT 101
+V P+ + EE I ++ E+ V EE +++ + +I EE+V +
Sbjct: 6689 -EVVPEELVEKLIPEELVEEVIPELLVEEVVPEEVVEELIPEELVEEVIPEELVEEVIPE 6747
Query: 100 TIRGEPIQDGHEEDKVTEELKIDGAKKDIGE 8
+ E I++ E+ + EEL + +++ E
Sbjct: 6748 EVPEEVIREELVEEVIPEELVEEVIPEEVPE 6778
Score = 115 bits (288), Expect = 1e-22
Identities = 250/1161 (21%), Positives = 489/1161 (42%), Gaps = 46/1161 (3%)
Frame = -1
Query: 3352 PEKIGQMEDRDYENKEGVKMVTEETS--LQKSEVEESWSPDNTHSHLLDETSLKPIDLQK 3179
PE+I +E+ YE ++V E + L K V E + T +++E + P + +
Sbjct: 3399 PEEI--VEEVIYEEVIPEELVEEVIAEKLVKEIVPEQVREEVTLEEIVEE--MIPEEFVE 3454
Query: 3178 ERNDENATEPKIQDTKIMDIIGRVDIDDEEVPEQL-EKDQPEM--EQNDRKELPPEMKHE 3008
E E E I + I ++I V ++ E VPE+L EK PE+ E+ KE PE+ E
Sbjct: 3455 EVAPEVEIEEIIPEELIEEVIPEVLVE-EAVPEELIEKVIPEVLVEEIIYKEGIPEVLIE 3513
Query: 3007 DLDFKGNGAQDVDGTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIES 2828
++ P E + + V EV ++ EE + + + T +
Sbjct: 3514 EV------------IPEELVQEVIPEEIVEEVVPEEFIEEMIPQEVVKEVITEKFIEEMI 3561
Query: 2827 SKEDNEAKKPEEEINEGLDIGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKAN 2648
+E E PEE I E + EE E +VE + + + EE I++ E+
Sbjct: 3562 PEEVVEEVIPEEFIEEMIPEVVVEEVVPEELVEEMLPEELIEVVVPEELIEEVIPEELVE 3621
Query: 2647 EVLEIAGVGKDDGETVMEEDVVPDPSTTTIGEEPTKDG-HEEDKVIEISKIDSVDKDIGE 2471
EV+ E ++EE V+P+ + E ++ HE + + ++ V ++ E
Sbjct: 3622 EVV---------AEELVEE-VIPEELVEKVVPEVVEEFIHEVVEEVVPEVVEEVVPEVVE 3671
Query: 2470 SIIKE---NVVPDVSTTTIGEAQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTT 2300
++ E VVP+V + E + V E ++E + + EEV + ++VV +
Sbjct: 3672 EVVPEVVEEVVPEVVEEVVPEVVEEVVPE---VVEEVVPEVVEEVVPEVVEEVVPEVVEE 3728
Query: 2299 TIGEETIK------CGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKII 2138
+ EE ++ EE E V E + + E+++
Sbjct: 3729 VVPEELVEEVIPEVLFEEEIPEELVEVVPVELLEEAIPEELVEEVIPEELVEEVIPEELV 3788
Query: 2137 EQ--PEIVGADREIREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNG 1964
E+ PE + + I E ++EE + +L EE +++ V E + +D
Sbjct: 3789 EEVIPEEL-VEEVILEELVEEVIPEELVEEVIPEELVEEVIPEVLVEEEIPEKLVEEDIP 3847
Query: 1963 DPTIEGEVVPNHSITTIGEESTNDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTT 1784
+ +E EVVP + + E + +++V E+ ++ K
Sbjct: 3848 EKLVE-EVVPEELVEVVIPEELVEEVIPEELVKEVIPEELVKEVVPEELVEEEIPKVVEE 3906
Query: 1783 TIGEEPIQDGPAENKVIEGLEKVDLDEHIGEHITEKDVAPDHSITSFEEEPIKDFHEEDK 1604
+ EE +++ E V E + ++ ++E + E + E +V P+ EE +++ E+
Sbjct: 3907 VLPEELVEEVMLEEVVEEVVPEI-VEEVVPEELVE-EVVPEVVEEVVPEEIVEEVIPEEL 3964
Query: 1603 VIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGANKDIG 1424
V E + +++ + ++ EE+V + + E I + EE V EEL + K +
Sbjct: 3965 VEEVVK-----EELVEEVVKEELVEEVVKEELVEEVIPEVLVEEVVPEELLEEVIPKVLV 4019
Query: 1423 ESSIKDVVLDQSTTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDHPTKTIGEIK 1244
E I ++++++ + E V + EE + I E +++E + P K + E+
Sbjct: 4020 EEVIPELLVEEVVPEVIEEVVPEVVEEVVPEELLEEVIPEVLVEEEI----PEKLVEEVV 4075
Query: 1243 DKHEEDKVI----------EGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHED 1094
+ ++VI E L + ++ V E + EE + E+
Sbjct: 4076 PEELVEEVIPEVLVEEVVPEELVEEVISEELVEEVIPEELVEEVIPEEVVEEVVPEVVEE 4135
Query: 1093 KVIEGLE-----IVDDVVPKPSTTITGE---EAIRNGQEE--NKVIEELEIVDAEEDIGE 944
V E +E +V++VVP+ + E E + EE +V+EE+ EE +
Sbjct: 4136 VVPEVVEEVVPEVVEEVVPEVVEEVVPEVVEEVVPEVVEEVVPEVVEEVVPEVVEEVV-- 4193
Query: 943 PIIEKDVVPGHTT--TIGEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEHSTTT 770
P + ++VVP I EE++ +V + V E ++ E +V++VIPE
Sbjct: 4194 PEVVEEVVPEELIEEVIPEEIVEEVIPEELVAEVIPEKLVEEVIPEELVEEVIPEELVEE 4253
Query: 769 SVGESIKDAHXXXXXXXXXXIVGADKEIREPAIKEDVVPD--LSTTTREEPIQDGHDINK 596
+ E + + ++ + E I E+V+P+ + EE I++
Sbjct: 4254 VIPEELVEEVLPEEVVEEAVPEVVEEIVPEELI-EEVIPEELIKEVVPEEVIEEVITEEV 4312
Query: 595 VGEGLEIAGSDKDNGDPIIEEEVIPDHSTTIIGEESTNDGHEEDKVVAVLDIVGVDKDIG 416
V E L ++ + ++ EEVI + ++ EE + E+ V V+ V++ +
Sbjct: 4313 VEEVLP-----EEIVEEVLPEEVIEE----VVPEELVEEVLPEEVVEEVVPEELVEEVVP 4363
Query: 415 EPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPITEKDVAPDNFIA 236
E ++E+ V+P E + + +++E L +L +++ ++V P+ +A
Sbjct: 4364 EELVEE-VIPEELVEEVLPEEVVEEVVPKELVEELIPEELVEEVIPEELVEEVVPEELVA 4422
Query: 235 -AFEEEAIKDVHEEDKVIE--ETEIIGAD--KDIGDHIIGEEIVPDHSTTTIRGEPIQDG 71
EE +++V E+ V E E++ + +++ + +I EE+V + + E + +
Sbjct: 4423 EVIPEELVEEVIPEELVEEVIPEELVEEEIPEELVEEVILEELVEEVVPEELIEEVVPEE 4482
Query: 70 HEEDKVTEELKIDGAKKDIGE 8
E+ V EEL + +K I E
Sbjct: 4483 LIEEVVPEELIEEVVEKVIPE 4503
Score = 114 bits (284), Expect = 3e-22
Identities = 242/1125 (21%), Positives = 469/1125 (41%), Gaps = 36/1125 (3%)
Frame = -1
Query: 3274 LQKSEVEESWSPDNTHSHLLDETSLKPI--DLQKERNDENATEPKIQDTKIMDIIGRV-- 3107
L + EV E + L++E + + +L E +E E +++ ++++ V
Sbjct: 7439 LVEEEVPEELVEEVIPEELVEEVIPEELVEELIPEVLEEVIPEKLVEEVVPVELLEEVIP 7498
Query: 3106 -DIDDEEVPEQLEKDQPE--MEQNDRKELPPEMKHEDLDFKGNGAQDVDGTPIEQINQGS 2936
++ +E VPE L + PE +E+ +E+ E+ E+L ++V P E + +
Sbjct: 7499 EELIEEVVPEVLVEVIPEKVVEEVIHEEIVKEVVPEEL------VEEV--VPEEIVEEVV 7550
Query: 2935 KMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPEEEINEGLDIGGAE 2756
+ EV K + EE K + + EL +E E PEE + E + E
Sbjct: 7551 PEEVLEEVIPKVLLEEEIPEKLVEEVIPEELIEEVVPEELVEEVMPEEVVEEVVPEELVE 7610
Query: 2755 EDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKDDGETVMEEDVVPD 2576
E E +VE I EE +++ + E++ + + + E ++EE + +
Sbjct: 7611 EVIPEEVVEE---------VIPEELVEEVVPVELLEEIVPVELLEEVIPEELVEEVIPEE 7661
Query: 2575 PSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDVSTTTIGEAQTKDVR 2396
+ EE + E V E+ V++ I E +++E V ++ I E ++V
Sbjct: 7662 LVEEVVPEELVAEVIPEKLVEEVIPEKLVEEVIPEELVEEVVPEELVAEVIPEKLVEEVI 7721
Query: 2395 EEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCGHEEERELXXXXXXXXXXX 2216
E+ + E I +E V + + +++V++ + EE I EL
Sbjct: 7722 PEELVEE---IIPEELVEEVVPEELVEEVVPEELVEEVI------PEELVEEVIPEVLVE 7772
Query: 2215 XXXXXXAVPATGEEPIKDGHEKEKIIEQPEIVGADREIREPVIEEDVVPDLSTTTTREEP 2036
V EE I + +E + E+ V E+ E V+ E++V ++ EE
Sbjct: 7773 EEVPEELV----EEVIPEELVEEMLPEELIEVVVPEELVEEVVPEELVEEVVPEEVVEEV 7828
Query: 2035 IQDGHDINKVIEGLEIASSNKDNGDPTIEGEVVPNHSITTIGEESTNDGQEEDKVVAE-L 1859
I + I +++ +EI + + E+VP I + + + + VV E +
Sbjct: 7829 IPE-ELIEELVPEVEIEEILPEE----LIEELVPEEIIEEVIPKELIEEVIPEVVVEEVV 7883
Query: 1858 DIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAENKVIEGLEKVDLDEHIGEHITE 1679
V V + + EE ++D E V E + + ++E I E + E
Sbjct: 7884 PEVLVEEVVPEELVEEVIPEVLVEEEVPEELVEDVIPEELVEEVVPEELVEEVIPEEVVE 7943
Query: 1678 KDVAPDHSITS-FEEEPIKDFHEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRG 1502
+V P+ + EE +++ E+ V E ++ I + ++ EE++P+ +
Sbjct: 7944 -EVLPEELVEEVVPEEIVEEVIPEELVEEEVPEELVEEVIPEEVV-EEVIPEEVPEKVIP 8001
Query: 1501 EPIQDDHEEEKVIEELKIDGANKDIGESSIKDVVLDQSTTS--IGETPVKDAHEEHKVRV 1328
E + ++ E+V+EEL + +++ + + V+ I E V++ E V
Sbjct: 8002 EKLVEELIPEEVVEELIPEEVVEEMVPIEVVEEVVPTEVLEEVIPEIVVEEVVPEELVEE 8061
Query: 1327 GANKDIGEPIIKENVVLDHPTKTIGE-------IKDKHEEDKVIEGLDNDCVNXXXXXXX 1169
+++ E +I E VV + + + E +++ E+ V E + + V
Sbjct: 8062 VIPEELVEEVIPEIVVEEVVPEELVEEVIPEELVEEVVPEELVEEVVPEEIVEELLPKEI 8121
Query: 1168 XXXXGVREHSTKTTWEEPTKDGHEDKVIEGL--EIVDDVVPKPSTTITGEEAIRNGQEE- 998
E + EE + ++V+E + E+V++VVP+ + EE + E
Sbjct: 8122 VEEVIYEEQVEEVIHEELVAEVIPEEVVEEVVPEVVEEVVPEIVAEVIPEEVVEEVVPEV 8181
Query: 997 -----NKVIEEL---EIVD-------AEEDIGEPIIEKDVVPGHTTTIGEELINDVHDDN 863
+V+EE+ E+V+ EE I E I+E+ V I EEL+ +V +
Sbjct: 8182 VEEVVPEVVEEVIPEEVVEEVIPEEFIEEMIPEEIVEEVVPEVVEEVIPEELVAEVIPEE 8241
Query: 862 KVIEGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAHXXXXXXXXXXIVGADKEIR 683
V E V +++ E VV++V+PE V E I + E+
Sbjct: 8242 LVEEVIPEVLFEEEIPEVVVEEVVPE-----VVEEEIPEVVVEEVV----------PEVV 8286
Query: 682 EPAIKEDVVPDLSTTTREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHSTTI 503
E I E+VV +L EE +++ I V E + ++ + ++EE V + +
Sbjct: 8287 EEVIPEEVVEEL---IPEEVVEEMVPIEIVEEVVPTEVLEEVIPEIVVEEVVPEELVEEV 8343
Query: 502 IGEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKV 323
I EE + E+ V V+ V V++ + P + + VVP EE I + E V
Sbjct: 8344 IPEELVEEVVPEELVEEVVPEV-VEEVV--PEVVEEVVPEELV----EEVIPEVVVEEVV 8396
Query: 322 IEGLEKVDLDKDIGEPITEKDVAPDNFIAAFEEEAIKDVHEEDKVIEETEIIGADKDIGD 143
E L + + +++ E I +++ + EE + +V E+ + EE +++ +
Sbjct: 8397 PEELVEEVIPEELVEEIIPEEIVEEVIPEELIEEVVPEVLVEEVIPEELVEEVIPEELFE 8456
Query: 142 HIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEELKIDGAKKDIGE 8
++ EE+V + I E I + E+ V EEL + +++ E
Sbjct: 8457 EVVPEELVAEVIPEEIVEEVIPEELIEEFVPEELVEEEVPEELVE 8501
Score = 113 bits (283), Expect = 4e-22
Identities = 238/1067 (22%), Positives = 460/1067 (43%), Gaps = 20/1067 (1%)
Frame = -1
Query: 3181 KERNDENATEPKIQDTKIMDIIGRVDIDD---EEVPEQLEKDQPEMEQNDRKELPPEMKH 3011
+E E E I + + ++I V+I++ EE+ E+L ++ +E+ KEL E+
Sbjct: 2701 EEMIPEELVEEVIPEEVVEEVIPEVEIEEILPEELIEELVAEEV-IEEVIPKELIEEVIP 2759
Query: 3010 EDLDFKGNGAQDVDGTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIE 2831
E L +DV P E + + V EV +++ EE ++L E+
Sbjct: 2760 EKL------IEDV--VPEEIVEEVLPEEVVKEVIPEEVVEEVLP-EELVEEVIPEVVEEV 2810
Query: 2830 SSKEDNEAKKPEEEINEGLDIGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKA 2651
+E E P+E + E + EE E I+E V + I +E I++A E+
Sbjct: 2811 VPEELVEEVLPKEVVEEVIPEVEIEEILPEEIIEELVAKEVIEEVIPKELIEEAITEEVV 2870
Query: 2650 NEVLEIAGVGKDDGETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGE 2471
E++ + + E V+EE + + + EE ++ E+ V E + V++ I E
Sbjct: 2871 EEMIPEEIIEEVVPEEVIEEVITEEVVEEVVPEEVIEEVITEEVVEEAIPEEVVEEVIPE 2930
Query: 2470 SIIKENVVPDVSTTTIGEAQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIG 2291
I+E + ++ + E T++V E+ + E ++ +E + + I K+V+ ++ +
Sbjct: 2931 VEIEEVLPEELIEELVPEEVTEEVITEEVVEEAISEVVEEVIPEEIVKEVIPEE----VV 2986
Query: 2290 EETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQPEIVGAD 2111
EE I E E+ +P E + + E+++E E+V
Sbjct: 2987 EEIIT--EEIAEEIIPKELVEEVIPEEVVVEIIP----EKLVEEFVSEELVE--ELV--P 3036
Query: 2110 REIREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVVPN 1931
EI E V+ E++V ++ EE + + +++E + ++ + EV+P
Sbjct: 3037 EEIVEKVVPEELVEEIVPEELVEEVVPE-----ELVEEVIPEELVEEFIPEEVVEEVLPE 3091
Query: 1930 HSITTIGEESTNDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGP 1751
+ EE ++ EE VV E + +V I EE +++
Sbjct: 3092 QLV----EEVISEVVEE--VVPEELVEEV---------------------IPEEVVEELV 3124
Query: 1750 AENKVIEGLEKVDLDEHIGEHITEKDVAPDHSITS-FEEEPIKDFHEEDKVIEGTEIVGA 1574
AE + E + K ++E I E + E V P+ + EE +K+ E +E EI+
Sbjct: 3125 AEEVIEEVIPKELIEEAITEEVEE--VIPEEIVEEVIPEEVVKEVIPE---VEIEEIL-- 3177
Query: 1573 DKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEE----EKVIEELKIDGANKDIGESSIKD 1406
+++ + ++ +E++ + T + E I ++ + E+V+EE+ + +++ + D
Sbjct: 3178 PEELIEELVAKEVIEEVITEEVAEEVIPEEIVQEVIPEEVVEEIITEVEIEEVLPEELID 3237
Query: 1405 VVLDQSTTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLD-HPTKTIGEIKDKHEE 1229
V+ + T E ++ E V+ ++I E +I + +V + P + + EI + E
Sbjct: 3238 EVVPEEVTE--EVITEEVMPEEVVKEVIPEEIAEEVIPKELVEEVIPEEVVEEIIPEVEI 3295
Query: 1228 DKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVIEGLEIVDDVVPK 1049
++V+ + E + EE D ++V+ E+V++V+P+
Sbjct: 3296 EEVL-----------------PEEVIEEVVPEVEIEELIPDEVVEEVLPE-ELVEEVIPE 3337
Query: 1048 P-STTITGEEAIRNGQEENKVIEELEIVDAEEDIGEPIIEKDVVPGHTTTIGEELINDVH 872
+ + EE I E V E + EE I E IIE+ VVP EELI +V
Sbjct: 3338 EVAVEVVPEEVIEEAVPEEIVEEFIPEEQIEEVIQEEIIEQ-VVP-------EELIEEVV 3389
Query: 871 DDNKVIEGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGES-IKDAHXXXXXXXXXXIVGAD 695
+ E E V ++ E + ++VIPE + E +K+
Sbjct: 3390 PE----EIIEEVIPEEIVEEVIYEEVIPEELVEEVIAEKLVKEI--------------VP 3431
Query: 694 KEIREPAIKEDVVPDLSTTTREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDH 515
+++RE E++V EE I + + +V +EI + II EE+I +
Sbjct: 3432 EQVREEVTLEEIV--------EEMIPE-EFVEEVAPEVEI--------EEIIPEELIEEV 3474
Query: 514 STTIIGEESTNDGHEEDKVVAVL--DIV---GVDKDIGEPVIEDNVVPNHSTTTTGEEPI 350
++ EE+ + E + VL +I+ G+ + + E VI + +V EE +
Sbjct: 3475 IPEVLVEEAVPEELIEKVIPEVLVEEIIYKEGIPEVLIEEVIPEELVQEVIPEEIVEEVV 3534
Query: 349 QDGQAENKV-IEGLEKVDLDKDIGEPITE---KDVAPDNFIAAFEEEAIKDVHEEDKVIE 182
+ E + E +++V +K I E I E ++V P+ FI EE I +V E+ V E
Sbjct: 3535 PEEFIEEMIPQEVVKEVITEKFIEEMIPEEVVEEVIPEEFI----EEMIPEVVVEEVVPE 3590
Query: 181 ETEIIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEEL 41
E +++ + ++ EE++ + + E + + E+ + EEL
Sbjct: 3591 ELVEEMLPEELIEVVVPEELIEEVIPEELVEEVVAEELVEEVIPEEL 3637
Score = 112 bits (279), Expect = 1e-21
Identities = 249/1147 (21%), Positives = 458/1147 (39%), Gaps = 73/1147 (6%)
Frame = -1
Query: 3262 EVEESWSPDNTHSHLLDET---SLKPIDLQKERNDENATEPKIQDTKIMDIIGRVDIDDE 3092
E+ E P+ ++ E + P +L +E E E I + + ++I +I +E
Sbjct: 5795 EIVEEVIPEEIVEEVMPEEVAEEVVPEELVEEEVPEELVEEVIPEVLVEEVIPE-EIVEE 5853
Query: 3091 EVPEQ----------LEKDQPE--MEQNDRKELPPEMKHEDLDFKGNGAQDVDGTPIEQI 2948
VPE+ +E+ PE + + +EL EMK E+L ++V P E I
Sbjct: 5854 VVPEEVVEVVIPEEFIEEIIPEEVVVEVTPEELIEEMKPEEL------FEEV--IPKELI 5905
Query: 2947 NQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPEEEINEGLDI 2768
+ + EV ++I EE + + E+ +E E PEE + E +
Sbjct: 5906 EEIIPEELIKEVIPEEIIEE---------VISKEIVEEVVEEEIIEEVIPEEIVEEVVPE 5956
Query: 2767 GGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKDDGETVMEED 2588
E+ E IVE + + + EE I++ E+ E+ + ++ E ++ E+
Sbjct: 5957 ELVEKKVPEEIVEEVIYEEFLEEIMPEELIEEMKPEELIEEI-----IPREIVEEIITEE 6011
Query: 2587 VVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDVSTTTIGEAQT 2408
VV + + EE + E+ V E + V +++ E +I E ++ +V I E
Sbjct: 6012 VVEEMKPEELVEEMVPEEVVEEMVPEEVVEEMVPEEVVEEVITEKLIEEVVPEEIIEELI 6071
Query: 2407 KDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCGHEEERELXXXXXXX 2228
+ E+ I E L + + I ++VV++ + EE + E E+
Sbjct: 6072 PEELVEEVIPEKL-------IEEMIPEEVVEEMLLEEVVEEVVP--EVEIEEMIPEQLVE 6122
Query: 2227 XXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQPEIVGADREIREPVIEEDVVPDLSTTTT 2048
+P EE I + +E + E+ E+ E VI E ++ ++
Sbjct: 6123 EVVPEELVEKEIPEVVEEIITEEVVEEMVPEEVVEEMVPEEVVEEVILEKLIEEVVPVEV 6182
Query: 2047 REEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVVPNHSI-----TTIGEESTNDGQE 1883
EE + + +VIE + ++ + EVVP I + EE + E
Sbjct: 6183 IEEVVPE-----EVIEEVIPEKLIEEIIPEVLVEEVVPEELIEEVIPEVLFEEVVPEVVE 6237
Query: 1882 E-------DKVVAELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAENKV---- 1736
E +KVV E + +V + T + EE I + E +
Sbjct: 6238 EVVPEELVEKVVPEEIVEEVIPEFVEEVISEEIVEEVVTEELIEEMIPEEVVEEVIPEEL 6297
Query: 1735 ------IEGLEKVD----LDEHIGEHITE-----------------KDVAPDHSITSFEE 1637
+E +E+V L+E I E + E ++V P+ +
Sbjct: 6298 VEEVVPVELIEEVVPVELLEEVIPEELVEEVVPVELIEEVVPVELLEEVIPEEVVEEVIP 6357
Query: 1636 EPIKDFHEE------DKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEE 1475
E +K+ E +V+E E+V + P + EE+VP+ + E + +
Sbjct: 6358 EVVKEVVPEVVEEVVPEVVE--EVVPEVVEEVVPEVVEEVVPEELIEEVIPEELIKEVLP 6415
Query: 1474 EKVIEELKIDGANKDIGESSIKDVVLDQSTTS--IGETPVKDAHEEHKVRVGANKDIGEP 1301
E+VIEELK + ++I + + V+ + I E V++ E V + + E
Sbjct: 6416 EEVIEELKPEELIEEIIPEEVVEEVIPEELIEEMIPELLVEEEVPEELVEEVIPEVLVEE 6475
Query: 1300 IIKENVVLD-HPTKTIGEIKDKHEEDKVI-EGLDNDCVNXXXXXXXXXXXGVREHSTKTT 1127
++ E +V + P + I E + +KVI E + + V+ V E
Sbjct: 6476 MVPEEIVEEVIPEELIAEFAPEELFEKVIPEEVVEELVS--EELVEEVLPEVVEEVLPEV 6533
Query: 1126 WEEPTKDGHEDKVIEGLEIVDDVVPKPSTTITGEEAIRNGQEENKVIEELEIVDAEEDIG 947
+EE + ++++ E++++VVPK EE I E + EE+ AEE +
Sbjct: 6534 FEEVIPEEVIEEIVPE-EVMEEVVPKELI----EEVIPEELIEEVIPEEV----AEEVVP 6584
Query: 946 EPIIEKDVVPGH--TTTIGEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEHSTT 773
E +IE +V+P + EELI +V + V E ++ E VV++VIPE
Sbjct: 6585 EKLIE-EVIPEELIKEVVPEELIEEVITEEVVEEAISEELVEEVVPEEVVEEVIPEELIE 6643
Query: 772 TSVGESIKDAHXXXXXXXXXXIVGADKEIREPAIKEDVVPD--LSTTTREEPIQDGHDIN 599
V E + + +E+ + E+V+P+ + EE ++
Sbjct: 6644 EVVPEELIEEIIPEELVEEVIPEELVEEVVPEELVEEVIPEELVEEVVPEELVEKLIPEE 6703
Query: 598 KVGEGLEIAGSDKDNGDPIIEEEVIPDHST-TIIGEESTNDGHEEDKVVAVLDIVGVDKD 422
V E + ++ EEV+P+ +I EE + E+ V V + ++
Sbjct: 6704 LVEEVI----------PELLVEEVVPEEVVEELIPEELVEEVIPEELVEEV-----IPEE 6748
Query: 421 IGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPITEKDVAPDNF 242
+ E VI + +V EE I + E V E L + + +++ E + ++V +
Sbjct: 6749 VPEEVIREELVEEVIPEELVEEVIPEEVPEEVVPEELVQEVIPEELVEEVVHEEVPEEVV 6808
Query: 241 IAAFEEEAIKDVHEEDKVIEETEIIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEE 62
EE I + E+ V EE +++ + +I EE+V + + E I + E
Sbjct: 6809 PEKLVEEVIPEELFEEVVPEEVPEEVVPEELVEEVISEELVEEVIPEELVEEFIPEELVE 6868
Query: 61 DKVTEEL 41
+ + EEL
Sbjct: 6869 EVIPEEL 6875
Score = 112 bits (279), Expect = 1e-21
Identities = 255/1201 (21%), Positives = 498/1201 (41%), Gaps = 54/1201 (4%)
Frame = -1
Query: 3481 EKVVADDLYTHNISIEEVKQSGFQEKELECKEQSSNSMGMVKDPEKIGQMEDRDYENKEG 3302
E+V+ ++L + EE+ + E+ +E +E + V E + ++ + K
Sbjct: 7943 EEVLPEEL-VEEVVPEEIVEEVIPEELVE-EEVPEELVEEVIPEEVVEEVIPEEVPEKVI 8000
Query: 3301 VKMVTEETSLQKSEVEESWSPDNTHSHLLDETSLKPIDLQKERNDENATEPKIQDTKIMD 3122
+ + EE L EV E P+ ++ PI++ +E E I + + +
Sbjct: 8001 PEKLVEE--LIPEEVVEELIPEEVVEEMV------PIEVVEEVVPTEVLEEVIPEIVVEE 8052
Query: 3121 IIGRVDIDDEEVPEQL-EKDQPEM--EQNDRKELPPEMKHEDLDFKGNGAQDVDGTPIEQ 2951
++ ++ +E +PE+L E+ PE+ E+ +EL E+ E+L ++V P E
Sbjct: 8053 VVPE-ELVEEVIPEELVEEVIPEIVVEEVVPEELVEEVIPEEL------VEEV--VPEEL 8103
Query: 2950 INQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPE--EEINEG 2777
+ + V E+ K+I EE + + + EL +E E PE EE+
Sbjct: 8104 VEEVVPEEIVEELLPKEIVEEVIYEEQVEEVIHEELVAEVIPEEVVEEVVPEVVEEVVPE 8163
Query: 2776 LDIGGAEEDTGEHIVEN---DVILDHNRTTIQEEAIKDAHKEDKANEVLE---IAGVGKD 2615
+ E+ E +V +V+ + I EE +++ E+ E++ + V +
Sbjct: 8164 IVAEVIPEEVVEEVVPEVVEEVVPEVVEEVIPEEVVEEVIPEEFIEEMIPEEIVEEVVPE 8223
Query: 2614 DGETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESI---IKENVVP 2444
E V+ E++V + + EE + E+++ E+ + V + + E I + E VVP
Sbjct: 8224 VVEEVIPEELVAEVIPEELVEEVIPEVLFEEEIPEVVVEEVVPEVVEEEIPEVVVEEVVP 8283
Query: 2443 DVSTTTIGEAQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCGHE 2264
+V I E +++ E+ + E + I+ EEV + +V+++ + EE + E
Sbjct: 8284 EVVEEVIPEEVVEELIPEEVVEEMVPIEIVEEV---VPTEVLEEVIPEIVVEEVVP--EE 8338
Query: 2263 EERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEK---EKIIEQ--PEIVGAD---R 2108
E+ VP EE + + E+ E+++E+ PE+V +
Sbjct: 8339 LVEEVIPEELVEEVVPEELVEEVVPEVVEEVVPEVVEEVVPEELVEEVIPEVVVEEVVPE 8398
Query: 2107 EIREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGE----V 1940
E+ E VI E++V ++ EE I + V E L ++ + I E V
Sbjct: 8399 ELVEEVIPEELVEEIIPEEIVEEVIPEELIEEVVPEVLVEEVIPEELVEEVIPEELFEEV 8458
Query: 1939 VPNHSIT----------TIGEESTNDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHS 1790
VP + I EE + E+ V E+ V + +
Sbjct: 8459 VPEELVAEVIPEEIVEEVIPEELIEEFVPEELVEEEVPEELVEEVIPEVLVEEVIPEEFV 8518
Query: 1789 TTTIGEEPIQDGPAENKVIEGLEKVDLDEHIGEHITE--KDVAPDHSITSFEEEPIKDFH 1616
I EE +++ E V E + + ++E + E + E + + + EE + +
Sbjct: 8519 EEVIPEEIVEEVIPEEIVEEVIPEEVVEEVVPEIVAEVIPEEVVEEVVPEVVEEVVPEVI 8578
Query: 1615 EE--DKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDG 1442
EE +VIE E+V + P + EE+VP+ + E +++ EE V+EE+
Sbjct: 8579 EEVVPEVIE--EVVPEVVEEVVPEVVEEVVPEVVEEVVPVEVLEEVIPEE-VVEEV---- 8631
Query: 1441 ANKDIGESSIKDVVLDQSTTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDHPTK 1262
I E I++++ ++ + V+D E + ++++ E I E +V P +
Sbjct: 8632 ----IPEEFIEEMIPEEIVEEVVPEVVEDVIPEELIAEVVSEELFEEEIPEELVEVVPVE 8687
Query: 1261 TIGEIKDKHEEDKVI-EGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVI 1085
+ E+ + ++VI E L + V V E + +EE + ++VI
Sbjct: 8688 LLEEVIPEELVEEVIPEELVEEVVPEELVEEVVPEELVEEVIPEELFEEVVPEELVEEVI 8747
Query: 1084 EGLEIVDDVVPKPSTT-ITGEEAIRNGQEENKVIEELEIVDAEEDIGEPIIEKDVVPGHT 908
EIV++V+P+ EE + E V E + V EE I E +E +V+P
Sbjct: 8748 PE-EIVEEVIPEELIEEFVPEELVEEEVPEELVEEVIPEVLVEEVIPEEFVE-EVIPEEL 8805
Query: 907 T--TIGEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAHXX 734
I EEL +V + V E ++ E ++++V+PE + E + +
Sbjct: 8806 VEEVIPEELFEEVVPEELVEEVIPEEIVEEVIPEELIEEVVPEVLVEEVIPEELVEEVIP 8865
Query: 733 XXXXXXXXIVGADKEIREPAIKEDVVPD--LSTTTREEPIQDGHDINKVGEGLEIAGSDK 560
E+ I E+V+P+ + EE +++ V E + ++
Sbjct: 8866 EELFEEVVPEELVAEVIPEEIVEEVIPEELIEEFVPEELVEEEVPEELVEEVIPEVLVEE 8925
Query: 559 DNGDPIIEE--------EVIPDHSTTIIGEESTNDGHEEDKVVAVLDIVGVDKDIGEPVI 404
+ + ++EE E++P+ ++ E + + V V+ V++ I E V+
Sbjct: 8926 EVPEELVEEVIPEELVEEMLPEELIEVVVPEELVEEVVPEIVEEVVPEELVEEVIPEEVV 8985
Query: 403 EDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPITEKDVAPDNFIAAFEE 224
E+ V+P E +++ E V+E + +L ++I I ++V P +
Sbjct: 8986 EE-VLPEKLVEEVVPEIVEEVAPE--VVEEVIPEELVEEIIPEILVEEVVPIEVVEEAVP 9042
Query: 223 EAIKDVHEEDKVIEETEIIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEE 44
E + + +K++EE +++ ++ EEIVP I E + + +V EE
Sbjct: 9043 EVVVEEVVPEKIVEEVVPEKVLEEVIPELLVEEIVPIEVVGEIVPEEVVEKIVPMEVVEE 9102
Query: 43 L 41
L
Sbjct: 9103 L 9103
Score = 105 bits (263), Expect = 9e-20
Identities = 231/1119 (20%), Positives = 461/1119 (41%), Gaps = 48/1119 (4%)
Frame = -1
Query: 3220 LLDETSLKPIDLQKERNDENATEPKIQDTKIMDIIGRVDIDDEEVPEQLEKDQPEMEQND 3041
LL+E + P++L +E E E I + + +++ ++ E +PE+L +E+
Sbjct: 7635 LLEE--IVPVELLEEVIPEELVEEVIPEELVEEVVPE-ELVAEVIPEKL------VEEVI 7685
Query: 3040 RKELPPEMKHEDLDFKGNGAQDVDGTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGT 2861
++L E+ E+L ++V P E + + V EV +++ EE + +
Sbjct: 7686 PEKLVEEVIPEEL------VEEV--VPEELVAEVIPEKLVEEVIPEELVEEIIPEELVEE 7737
Query: 2860 ISTGELAGIESSKEDNEAKKPEEEINEGLDIGGAEEDTGEHIVENDVILDHNRTTIQEEA 2681
+ EL +E E PEE + E + EE+ E +VE + + + EE
Sbjct: 7738 VVPEELVEEVVPEELVEEVIPEELVEEVIPEVLVEEEVPEELVEEVIPEELVEEMLPEEL 7797
Query: 2680 IKDAHKEDKANEVLEIAGVGKDDGETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISK 2501
I+ E+ EV V ++ E V+ E+VV + + EE + E+ + E
Sbjct: 7798 IEVVVPEELVEEV-----VPEELVEEVVPEEVVEEVIPEELIEELVPEVEIEEILPEELI 7852
Query: 2500 IDSVDKDIGESIIKENVVPDVSTTTIGEAQTKDVREEDKIIEGL------NIDADEEVGD 2339
+ V ++I E +I + ++ +V + E +V E+ + E L + +EEV +
Sbjct: 7853 EELVPEEIIEEVIPKELIEEVIPEVVVEEVVPEVLVEEVVPEELVEEVIPEVLVEEEVPE 7912
Query: 2338 SITKDVVQDQSTTTIGEETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDG 2159
+ +DV+ ++ + EE + E E+ VP EE +++
Sbjct: 7913 ELVEDVIPEE----LVEEVVP--EELVEEVIPEEVVEEVLPEELVEEVVP---EEIVEEV 7963
Query: 2158 HEKEKIIEQPEIVGADREIREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASS 1979
+E + E+ E+ E VI E+VV ++ E+ I + K++E L
Sbjct: 7964 IPEELVEEE-----VPEELVEEVIPEEVVEEVIPEEVPEKVIPE-----KLVEELIPEEV 8013
Query: 1978 NKDNGDPTIEGEVVPNHSITTIGEESTNDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXX 1799
++ + E+VP I + E + EE V+ E+ + +V
Sbjct: 8014 VEELIPEEVVEEMVP---IEVVEEVVPTEVLEE--VIPEIVVEEV--------------- 8053
Query: 1798 DHSTTTIGEEPIQDGPAENKVIEGLEKVDLDEHIGEHITEKDVAPDHSITSFEEEPIKDF 1619
+ EE +++ E V E + ++ ++E + E + E +V P+ + E + +
Sbjct: 8054 ------VPEELVEEVIPEELVEEVIPEIVVEEVVPEELVE-EVIPEELVEEVVPEELVEE 8106
Query: 1618 HEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGA 1439
++++E E++ K+I + +I EE V + + E I ++ EE V E ++
Sbjct: 8107 VVPEEIVE--ELL--PKEIVEEVIYEEQVEEVIHEELVAEVIPEEVVEEVVPE--VVEEV 8160
Query: 1438 NKDIGESSIKDVVLDQSTTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDHPTKT 1259
+I I + V+++ + E V + EE + I E I+E + P +
Sbjct: 8161 VPEIVAEVIPEEVVEEVVPEVVEEVVPEVVEEVIPEEVVEEVIPEEFIEEMI----PEEI 8216
Query: 1258 IGEIKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVIEG 1079
+ E+ + E+ + E L + + E + EE + E+++ E
Sbjct: 8217 VEEVVPEVVEEVIPEELVAEVIPEELVEEVIPEVLFEEEIPEVVVEEVVPEVVEEEIPE- 8275
Query: 1078 LEIVDDVVPKPSTTITGEEAIRNGQEEN--------KVIEELEIVDAEEDIGEPIIEKDV 923
+V++VVP+ + EE + E +++EE+ + E++ I+ ++V
Sbjct: 8276 -VVVEEVVPEVVEEVIPEEVVEELIPEEVVEEMVPIEIVEEVVPTEVLEEVIPEIVVEEV 8334
Query: 922 VPGHTT--TIGEELINDVHDDN-------KVIEGFEMVGSDKDTGEPVVDDVIPEHSTTT 770
VP I EEL+ +V + +V+E ++ E +V++VIPE
Sbjct: 8335 VPEELVEEVIPEELVEEVVPEELVEEVVPEVVEEVVPEVVEEVVPEELVEEVIPEVVVEE 8394
Query: 769 SVGESIKDAHXXXXXXXXXXIVGADKEIREPAIKEDVVPD------LSTTTREEPIQDGH 608
V E + + +E+ + E+VVP+ + EE I +
Sbjct: 8395 VVPEELVEEVIPEELVEEIIPEEIVEEVIPEELIEEVVPEVLVEEVIPEELVEEVIPEEL 8454
Query: 607 DINKVGEGLEIAGSDKDNGDPIIEEEVIPDHSTTIIGEESTNDGHEEDKVVAVLDIVGVD 428
V E L ++ + +I EE+I + + EE + E+ + VL +
Sbjct: 8455 FEEVVPEELVAEVIPEEIVEEVIPEELIEEFVPEELVEEEVPEELVEEVIPEVLVEEVIP 8514
Query: 427 KDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPITE--KDVA 254
++ E VI + +V EE I + E V E + +V ++ + E + E ++V
Sbjct: 8515 EEFVEEVIPEEIVEEVIPEEIVEEVIPEEVVEEVVPEIVAEVIPEEVVEEVVPEVVEEVV 8574
Query: 253 P-----------DNFIAAFEEEAIKDVHEE--DKVIEETEIIGADKDIGDHIIGEEIVPD 113
P + + EE + +V EE +V+EE + +++ + EE++P+
Sbjct: 8575 PEVIEEVVPEVIEEVVPEVVEEVVPEVVEEVVPEVVEEVVPVEVLEEVIPEEVVEEVIPE 8634
Query: 112 HSTTTIRGEPIQD----GHEEDKVTEELKIDGAKKDIGE 8
+ E I + ED + EEL + +++ E
Sbjct: 8635 EFIEEMIPEEIVEEVVPEVVEDVIPEELIAEVVSEELFE 8673
Score = 103 bits (258), Expect = 3e-19
Identities = 244/1231 (19%), Positives = 472/1231 (38%), Gaps = 83/1231 (6%)
Frame = -1
Query: 3484 KEKVVADDLYTHNISIEEVKQSGFQEK-ELECKEQSSNSMGMVKDPEKIGQMEDRDYENK 3308
K K V +L +N+S E K+ ++K ++ K+ + G +K K +++ + K
Sbjct: 129 KHKKVEINLNDNNLSNNESKRKSRRKKVKVNLKDNLAKREGKMKRRNK----KEKRRKEK 184
Query: 3307 EGVKMVTEETSLQKSEVEESWSPDNTHSHLLDETSLKPIDLQKERNDE--------NATE 3152
+ KM E L++ E S+LLD S D+ RND+ N
Sbjct: 185 DNKKM--NELKLKREYKE---------SYLLDNKS----DMDVIRNDKFSYFTLYKNNLF 229
Query: 3151 PKIQDTKIMDIIGRVDIDDEEVPEQLEKDQPEMEQNDRKELPPEMKHEDLDFKGNGAQDV 2972
P + + ++ D +++ + E + ++ +E+N+ + E + + KG G
Sbjct: 230 PN-SNNYFLHMLKTYDEENKGIDENTDINE-NVEENEYVDKNTEGDKDGDEDKGGGES-- 285
Query: 2971 DGTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKK--- 2801
E G G + G+ G E+ +DNE K
Sbjct: 286 --------------------------EGGDGHGSAGDSAGGDRGGDENKDKDNEENKDKK 319
Query: 2800 -------PEEEINEGLDIGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEV 2642
EEE E D E+D + E D + + ++E + K++K +E
Sbjct: 320 GNKDDDDEEEEEEEEDDEEKEEKDEKDEKDEKDEKDEKDEKDEKDEKDEKDEKDEK-DEK 378
Query: 2641 LEIAGVGKDDG-ETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESI 2465
E + G E ++E+ +P EE +D E DK E K + + G +
Sbjct: 379 DEKGEKDESKGEEKFLKEEKMPKK------EENMQDKIERDKEFEGFKDEYFTQMEGGAY 432
Query: 2464 IKENVVPDVSTTTIGEAQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEE 2285
+ + + E T+ V +K+IE + ++ D + +S + E
Sbjct: 433 ---GITVEHEGQKLRETLTEGVEGYEKVIE----EMEQTKLDEFLLPTNEGKSDDFVSE- 484
Query: 2284 TIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKI-IEQPEIVGADR 2108
EEER T EE I + EKI IE+ E+ +
Sbjct: 485 -----MEEERLFNFVSYMEEEVKDKMFIEREQGTEEEVIHEDLSDEKIGIEKKELETFVQ 539
Query: 2107 EIREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNK-DNGDPTIEGEVVPN 1931
++ + V++++ + + T E K+ E ++ K + IE E +
Sbjct: 540 DVSDEVLQDEQLIEEEKLTEEE----------KLTEEEKLTEEEKLTEDEQLIEEEKLTE 589
Query: 1930 HSITTIGEESTNDGQ--EEDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQ- 1760
T E+ T + + EE+K+ E + + K I E+ I
Sbjct: 590 EEKLTEEEKLTEEEKLTEEEKLTEEEKLTEEEKLTEEEKLTEEEKLTEEEIFIEEDKISP 649
Query: 1759 ---DGPAENKVIEGLEK--------------VDLDEHIGEHITEKDVAPDHSITSF-EEE 1634
+ P E+ ++E +EK D+DE + E D+ P+ I +EE
Sbjct: 650 KEVEEPLEDVLMEKMEKEYKEILHEGKSVVTQDMDEKLLSENLEDDLIPEEIIEELVDEE 709
Query: 1633 PIKDFHEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEEL 1454
+++ E+ V E V ++ I ++ EE++P+ + E + ++ E++IE +
Sbjct: 710 LVEEVTAEEIVEEFVAEVEIEEKIPKELV-EEVMPEEDVDEVVPEELVEEVVPEELIEGV 768
Query: 1453 KIDGANKDIGESSIKDVVLDQSTTS--IGETPVKDAHEEHKVRVGANKDIGEPIIKENVV 1280
+ +D+ + + V+ + + E V++ E V +++ E +I + VV
Sbjct: 769 IPEELVEDVIPEKVLEKVIPEEIIEELVLEEVVEEIKHEELVEEEIPEEVTEEVIPDEVV 828
Query: 1279 LDHPTKTIGE--IKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKD 1106
+ + + E +K++ E V E + + V V E + EE +
Sbjct: 829 EEVIPEELIEKVVKEELVEKVVAEEIVEEVVPEELVEKVVAEEIVEEVIPEELIEEVITE 888
Query: 1105 GHEDKVIEGLEIVDDVVPKPST-TITGEEAIRNGQEENKVIEELEIVDAEEDIGEPIIEK 929
++VI E+V++V+PK + EE ++ E V E + EE I E I+E
Sbjct: 889 KPAEEVIPE-ELVEEVIPKEIVEEVLPEEVVKEVIPEEVVEEVIPEELVEEVIPEEIVE- 946
Query: 928 DVVPGHTT-----------TIGEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEH 782
+VVP I EEL+ ++ + V E ++ T E VV++V+PE
Sbjct: 947 EVVPEELVEEMKPEEVVEEVISEELVEEMKPEEVVEEMKPEEVVEEVTPEKVVEEVVPEE 1006
Query: 781 STTTSVGESIKDAHXXXXXXXXXXIVGADKEIREPAIKEDVVPD-----------LSTTT 635
E + + +E+ + E+VVP+ +
Sbjct: 1007 LVEEMKPEEVVEEVISEELVEEMKPEEVVEEVTPEKVVEEVVPEELVEEMKPEEVVEEVI 1066
Query: 634 REEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHSTTIIGEESTNDGHEEDKVV 455
EE +++ V E + ++ + ++EE ++ EE + E+ V
Sbjct: 1067 SEELVEEMKPEEVVEEVISEELVEEMKPEEVVEEVTPEKVVEEVVPEELVEEMKPEEVVE 1126
Query: 454 AVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGEP 275
V+ V++ E V+E+ V P E + + +V+E + +L +++
Sbjct: 1127 EVISEELVEEMKPEEVVEE-VTPEKVVEEVVPEELVEEMKPEEVVEEVISEELVEEMKPE 1185
Query: 274 ITEKDVAPDNFI-AAFEEEAIKDV----------HEE--DKVIEETEIIGADKDIGDHII 134
++V P+ + EE ++++ HEE +K + E E+ +I
Sbjct: 1186 EVVEEVVPEELVEEVIPEEVVEEIIPEEVVHEAKHEELFEKTVPEVEVQEIIPKELVEVI 1245
Query: 133 GEEIVPDHSTTTIRGEPIQDGHEEDKVTEEL 41
EE++P+ + E I + ++V EE+
Sbjct: 1246 PEEVLPEELIEEVIPEEIIEEVIPEEVVEEV 1276
Score = 88.6 bits (218), Expect = 1e-14
Identities = 228/1067 (21%), Positives = 436/1067 (40%), Gaps = 31/1067 (2%)
Frame = -1
Query: 3262 EVEESWSPDNTHSHLLDETSLK---PIDLQKERNDENATEPKIQDTKIMDIIGRV----- 3107
E+ E P ++ E ++ P +L +E E E + + + +++ V
Sbjct: 8311 EIVEEVVPTEVLEEVIPEIVVEEVVPEELVEEVIPEELVEEVVPEELVEEVVPEVVEEVV 8370
Query: 3106 -DIDDEEVPEQL-EKDQPEM--EQNDRKELPPEMKHEDLDFKGNGAQDVDGT-PIEQINQ 2942
++ +E VPE+L E+ PE+ E+ +EL E+ E+L + + V+ P E I +
Sbjct: 8371 PEVVEEVVPEELVEEVIPEVVVEEVVPEELVEEVIPEELVEEIIPEEIVEEVIPEELIEE 8430
Query: 2941 GSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPEEEINEGLDIGG 2762
V V EV +++ EE + + EL +E E PEE I E +
Sbjct: 8431 VVPEVLVEEVIPEELVEEVIPEELFEEVVPEELVAEVIPEEIVEEVIPEELIEEFVPEEL 8490
Query: 2761 AEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKDDGETVMEEDVV 2582
EE+ E +VE + I EE +++ E+ EV+ V + E V+EE VV
Sbjct: 8491 VEEEVPEELVEEVIPEVLVEEVIPEEFVEEVIPEEIVEEVIPEEIVEEVIPEEVVEE-VV 8549
Query: 2581 PDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDVSTTTIGEAQTKD 2402
P+ I EE ++ E V+E + +++ + E I E VVP+V + E +
Sbjct: 8550 PEIVAEVIPEEVVEEVVPE--VVEEVVPEVIEEVVPEVI--EEVVPEVVEEVVPEVVEEV 8605
Query: 2401 VREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCGHEEERELXXXXXXXXX 2222
V E + E + ++ EEV I ++VV++ EE I E+
Sbjct: 8606 VPEV--VEEVVPVEVLEEV---IPEEVVEEVIPEEFIEEMIP------EEIVEEVVPEVV 8654
Query: 2221 XXXXXXXXAVPATGEEPIKDGHEKEKIIEQPEIVGADREIREPVIEEDVVPDLSTTTTRE 2042
EE ++ E+++E + + I E ++EE + +L E
Sbjct: 8655 EDVIPEELIAEVVSEELFEE-EIPEELVEVVPVELLEEVIPEELVEEVIPEELVEEVVPE 8713
Query: 2041 EPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVVPNHSIT-TIGEESTNDGQEEDKVVA 1865
E +++ V E + + + +E EV+P + I EE + E+ V
Sbjct: 8714 ELVEEVVPEELVEEVIPEELFEEVVPEELVE-EVIPEEIVEEVIPEELIEEFVPEELVEE 8772
Query: 1864 ELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAENKVIEGLEKVDLDEHIGEHI 1685
E+ V + + I EE +++ E E + + ++E I E I
Sbjct: 8773 EVPEELVEEVIPEVLVEEVIPEEFVEEVIPEELVEEVIPEELFEEVVPEELVEEVIPEEI 8832
Query: 1684 TEKDVAPDHSITSFEEEPIKDFHEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIR 1505
E +V P+ I E + + ++++E E++ +++ + ++ EE+V + I
Sbjct: 8833 VE-EVIPEELIEEVVPEVLVEEVIPEELVE--EVI--PEELFEEVVPEELVAEVIPEEIV 8887
Query: 1504 GEPIQDDHEEEKVIEELKIDGANKDIGESSIKDVVLDQSTTSIGETPVKDAHEEHKVRVG 1325
E I ++ EE V EEL + +++ E I +V++++ + E V++ E V
Sbjct: 8888 EEVIPEELIEEFVPEELVEEEVPEELVEEVIPEVLVEE---EVPEELVEEVIPEELVEEM 8944
Query: 1324 ANKDIGEPIIKENVVLDHPTKTIGEIKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVRE 1145
+++ E ++ E +V + + + E+ + ++VI
Sbjct: 8945 LPEELIEVVVPEELVEEVVPEIVEEVVPEELVEEVIP----------------------- 8981
Query: 1144 HSTKTTWEEPTKDGHEDKVIEGL--EIVDDVVPKPSTTITGEEAIRNGQEENKVIEELEI 971
EE ++ +K++E + EIV++V P+ + EE + E V E + I
Sbjct: 8982 -------EEVVEEVLPEKLVEEVVPEIVEEVAPEVVEEVIPEELVEEIIPEILVEEVVPI 9034
Query: 970 VDAEEDIGEPIIEKDVVPGHTT--TIGEELINDVHDDNKV--IEGFEMVGSDKDTGEPVV 803
EE + E ++E +VVP + E+++ +V + V I E+VG + E VV
Sbjct: 9035 EVVEEAVPEVVVE-EVVPEKIVEEVVPEKVLEEVIPELLVEEIVPIEVVG--EIVPEEVV 9091
Query: 802 DDVIPEHSTTTSVGESIKDAHXXXXXXXXXXIVGADKEIREPAIKED----VVPDLSTTT 635
+ ++P + E +++ ++E+ + I ED + ++
Sbjct: 9092 EKIVPMEVVEELLPEVVEEVPHEI----------VEEEVVKEVIPEDEKKVEIVEIIIEE 9141
Query: 634 REEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHSTTIIG--EESTNDGHEEDK 461
+ E I I K E +I K +E+E+ P + G ++ H +
Sbjct: 9142 KVEKIPKKKVIEKKKEKEKIRKPKKK-----VEKEIKPKEVKGVKGKLKKDVKAKHLKGS 9196
Query: 460 VVAVLDIV--GVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKD 287
V + + + ++ DI E ++E + +E I+D + KVI EK +
Sbjct: 9197 KVKITEDIQKKMEDDIKEKIMEKEL----------KEEIKDKEYLRKVIPKEEKKEPIPK 9246
Query: 286 IG---EPITEKDVAPDNFIAAFEEEAIKDVHEEDKVIEETEIIGADK 155
G EP EK A ++E + + +E + E + A K
Sbjct: 9247 KGKSVEPKKEKQ-------AGVKKEKVPETKKEKAPAPKKEKVQAPK 9286
>pir||S00485 gene 11-1 protein precursor - malaria parasite (Plasmodium
falciparum) (fragments)
Length = 1948
Score = 144 bits (363), Expect = 2e-31
Identities = 310/1426 (21%), Positives = 587/1426 (41%), Gaps = 65/1426 (4%)
Frame = -1
Query: 4117 KDSEDKVKPILTKTQEPESERQMQKDQTNDTVEATGDIIKGDKIDSCGEHA-LKKMSLDS 3941
+D E+K + K + E + + +KD+ ++ E KG+K +S GE LK+ +
Sbjct: 334 EDDEEKEE----KDDKDEKDEKDEKDEKDEKDEKDEKDEKGEKDESKGEEKFLKEEKMPK 389
Query: 3940 ARADNVGLVNSSALSTAPNDDDNIGEKLPAVPITSVSDDLNVQEGQTEGGNGAD--MDDM 3767
+ + D+ + A IT + ++E TEG G + +++M
Sbjct: 390 KEENMQDKIERDKEFEGFKDEYFTQMEGGAYGITVEHEGQKLRETLTEGVEGYEKVIEEM 449
Query: 3766 EQKNDVIFDDKQAPVVEHLQSGDIIRHHLVGNSKEVNGDQLTEGICASQSIEEDKAVTSS 3587
EQ D+ P E G S + + E + S E++
Sbjct: 450 EQTK---LDEFLLPTNE-------------GKSDDFVSEMEEERLFNFVSYMEEEVKDKM 493
Query: 3586 HEDQTEGTESGEDPDLKSGXXXXXXXXXXXEYYDKEKVVADDLYTHNISIE--------- 3434
++ +GTE E+V+ +DL I IE
Sbjct: 494 FIEREQGTE--------------------------EEVIHEDLSDEKIGIEKKELETFVQ 527
Query: 3433 EVKQSGFQEKELECKEQSSNSMGMVKDPEKIGQMEDRDYENK--EGVKMVTEETSLQKSE 3260
+V Q+++L +E+ + + EK+ + E E K E +++ EE ++ +
Sbjct: 528 DVSDEVLQDEQL-IEEEKLTEEEKLTEEEKLTEEEKLTEEEKLTEDEQLIEEEKLTEEEK 586
Query: 3259 VEESWSPDNTHSHLLDETSLKPIDLQKERNDENATEPKIQDTKIMDIIGRVDIDDEEVPE 3080
+ E T L E K + +K +E TE +I I I +EV E
Sbjct: 587 LTE--EEKLTEEEKLTEEE-KLTEEEKLTEEEKLTEEEI-------FIEEDKISPKEVEE 636
Query: 3079 QLEKDQPEMEQNDRKELPPEMKH---EDLDFK--GNGAQDVDGTPIEQINQGSKMVQVTE 2915
LE E + + KE+ E K +D+D K +D D P E I + V E
Sbjct: 637 PLEDVLMEKMEKEYKEILHEGKSVVTQDMDEKLLSENLED-DLIPEEIIEELVDEELVEE 695
Query: 2914 VTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPEEEINEGLDIGGAEEDTGEHI 2735
VT ++I EE ++ EL +ED + PEE + E ++ EE T E +
Sbjct: 696 VTAEEIVEEFVVEVEIEEKIPKELVEEVMPEEDVDEVVPEELVEEPDEV--VEEVTTEEL 753
Query: 2734 VENDVILDHNRTTIQEEAIKD--AHK--EDKANEVLEIAGVGKDDGETVME--EDVVPDP 2573
E + + ++EE ++ A K E E++E K E + E E+V+P+
Sbjct: 754 TEEVIPEELIEKVVEEELVEKVVAQKIVEVIPEELIEEVITEKPAEEVIPELVEEVIPEE 813
Query: 2572 ST-TTIGEEPTKDGHEEDKVIEI---SKIDSVDKDIGESIIKENVVPD----------VS 2435
+ EE K+ E+ V E+ ++ V ++I E ++ E +V + +S
Sbjct: 814 IVEEVLPEEVVKEVIPEEVVEEVIPEEVVEEVPEEIVEEVVPEELVEEMKPEEVFEEVIS 873
Query: 2434 TTTIGEAQTKDVREE---DKIIEGL-------NIDADEEVGDSITKDVVQDQSTTTIGEE 2285
+ E + ++V EE +K++E + + +E V + + +++V++ + EE
Sbjct: 874 EELVEEMKPEEVVEEVTPEKVVEEVVPEELVEEMKPEEVVEEVVPEELVEEVIPEEVVEE 933
Query: 2284 TI--KCGHE-EERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQ-PEIVG 2117
I + HE + EL V EE + + +E I E+ E V
Sbjct: 934 IIPEEVVHEAKHEELFEKLVPEVEVEEIIPKELVEVIPEEVLPEELIEEVIPEEIIEEVV 993
Query: 2116 ADREIREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVV 1937
E+ E VI E++V ++ EE + + K+ E + +++ + I EVV
Sbjct: 994 IPEEVVEEVIPEEIVQEVIPEDLMEEVVPEEIIEEKIPEEIVEEEIHEEIVEEIIPEEVV 1053
Query: 1936 PNHSITTIGEESTNDGQEE---DKVVAELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEP 1766
+ E EE +++V E+ V+V + + EE
Sbjct: 1054 EEVVPAEVEEMIPEKIVEEVIPEELVEEVVPVEVLEEVV-------------PVEVLEEV 1100
Query: 1765 IQDGPAENKV-IEGLEKVDLDEHIGEHITE---KDVAPDHSITSFEEEPIKDFHEEDKVI 1598
I + E + +E LE+V +E + E I E +++ P+ + E +++ E+ V
Sbjct: 1101 IPEEVVEEVIPVEVLEEVIPEEVVEEVIPEEFIEEMIPEEIVEEVVPEVVEEVIPEELVE 1160
Query: 1597 EGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGANKDIGES 1418
E + ++ I + ++ EE++P+ + E + ++ + E+V+EE+
Sbjct: 1161 EVVPVELLEEVISEELL-EEVIPEELVEEVVPEELVEEMKPEEVLEEV------------ 1207
Query: 1417 SIKDVVLDQSTTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDHPTKTIGEIKDK 1238
I +V++++ I E V++ E V +++ E +I E +V + + + E++++
Sbjct: 1208 -IPEVLVEE---VIPEELVEEVIPEVLVEEEVPEELVEEVIPELLVEEVVPEVVEEVQEQ 1263
Query: 1237 HEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVIEGLEIVDDV 1058
E+ + E + + V V E + EE ++ E+ + E E++++V
Sbjct: 1264 LVEEFIPEEVVEELV---------PEELVEEVIPEEIVEEVVEEVVEEIIPE--EVIEEV 1312
Query: 1057 VPKPSTTITGEEAIRNGQEENKVIEEL--EIVD---AEEDIGEPIIEKDVVPGHTTTIGE 893
P P + EE I E + EEL E++ EE I E ++E+ V + E
Sbjct: 1313 RPGPEELV--EEVIPEELVEEVIPEELVAEVIPEELVEEVIPEELVEEVVPEVVEEVVPE 1370
Query: 892 ELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAHXXXXXXXXX 713
EL+ +V + V E V +++ E +V++VIPE + E + +
Sbjct: 1371 ELVEEVIPEELVEEVIPEVLVEEEVPEELVEEVIPEELVEEMLPEELIE----------- 1419
Query: 712 XIVGADKEIREPAIKEDVVPDLSTTTREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEE 533
V +E+ E + E++V ++ E + I ++ +EI + I+ E
Sbjct: 1420 --VVVPEELVEEVVPEELVEEVVPEEVVEEVIPEELIEELVPEVEI--------EEILPE 1469
Query: 532 EVIPDHSTTIIGEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEP 353
E+I + +I EE + E+ V V+ V++ + E ++E+ VVP EE
Sbjct: 1470 ELIEE----LIPEEIIEEVIPEELVAEVIPGEIVEEVVPEELVEE-VVPEEVV----EEV 1520
Query: 352 IQDGQAENKVIEGLEKVDLDKDIGEPITEKDVAPDNFIAAFEEEAIKDVHEEDKVIEETE 173
I E V E + + + K+I E + V FEE K++ EE+ E E
Sbjct: 1521 IPKEIVEEVVSEEVVEEVIPKEIAEEVLSAQV--------FEEVIPKEIVEEEVPEELVE 1572
Query: 172 IIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEELKI 35
+ A +++ + ++ EE+ + + E + +G E+ V EEL +
Sbjct: 1573 V--APEELVEEVVPEELSEEVVPEELVEEVVPEGLVEEVVPEELVV 1616
Score = 124 bits (310), Expect = 3e-25
Identities = 259/1191 (21%), Positives = 502/1191 (42%), Gaps = 44/1191 (3%)
Frame = -1
Query: 3481 EKVVADDLYTHNISIEEVKQSGFQEKELECKEQSSNSMGMVKDPEKIGQMEDRDYENKEG 3302
E+V+ +++ I EEV + E+ +E E + V E + +M+ + +
Sbjct: 816 EEVLPEEVVKEVIP-EEVVEEVIPEEVVE--EVPEEIVEEVVPEELVEEMKPEEVFEEVI 872
Query: 3301 VKMVTEETSLQKSEVEESWSPDNTHSHLLDET---SLKPIDLQKERNDENATEPKIQDTK 3131
+ + EE ++ EV E +P+ ++ E +KP ++ +E E E I +
Sbjct: 873 SEELVEE--MKPEEVVEEVTPEKVVEEVVPEELVEEMKPEEVVEEVVPEELVEEVIPEEV 930
Query: 3130 IMDIIGRVDIDDEEVPEQLEKDQPEMEQND--RKEL----PPEMKHEDLDFKGNGAQDVD 2969
+ +II + + + E EK PE+E + KEL P E+ E+L
Sbjct: 931 VEEIIPEEVVHEAKHEELFEKLVPEVEVEEIIPKELVEVIPEEVLPEEL----------- 979
Query: 2968 GTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPEEE 2789
IE++ + +V V +++ EE + + + +L +E E K PEE
Sbjct: 980 ---IEEVIPEEIIEEV--VIPEEVVEEVIPEEIVQEVIPEDLMEEVVPEEIIEEKIPEEI 1034
Query: 2788 INEGLDIGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKDDG 2609
+ E + EE E +VE +V+ I E+ +++ E+ EV+ + + +
Sbjct: 1035 VEEEIHEEIVEEIIPEEVVE-EVVPAEVEEMIPEKIVEEVIPEELVEEVVPVEVLEEVVP 1093
Query: 2608 ETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDVSTT 2429
V+EE + + I E ++ E+ V E+ + +++ I E I++E VVP+V
Sbjct: 1094 VEVLEEVIPEEVVEEVIPVEVLEEVIPEEVVEEVIPEEFIEEMIPEEIVEE-VVPEVVEE 1152
Query: 2428 TIGEAQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCGHEEE--R 2255
I E ++V + + E ++ + EEV I +++V++ + EE ++ EE
Sbjct: 1153 VIPEELVEEVVPVELLEEVISEELLEEV---IPEELVEE----VVPEELVEEMKPEEVLE 1205
Query: 2254 ELXXXXXXXXXXXXXXXXXAVPAT-GEEPIKDGHEKEKIIEQ------PEIVGADRE--- 2105
E+ +P EE + + +E I E PE+V +E
Sbjct: 1206 EVIPEVLVEEVIPEELVEEVIPEVLVEEEVPEELVEEVIPELLVEEVVPEVVEEVQEQLV 1265
Query: 2104 ---IREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGL---EIASSNKDNGDPTIEGE 1943
I E V+EE V +L EE +++ + +V+E + E+ + + +E E
Sbjct: 1266 EEFIPEEVVEELVPEELVEEVIPEEIVEEV--VEEVVEEIIPEEVIEEVRPGPEELVE-E 1322
Query: 1942 VVPNHSITTIGEESTNDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPI 1763
V+P + + E +++V E+ ++ + + I EE +
Sbjct: 1323 VIPEELVEEVIPEELVAEVIPEELVEEVIPEELVEEVVPEVVEEVVPEELVEEVIPEELV 1382
Query: 1762 QDGPAENKVIEGLEKVDLDEHIGEHITEKDVAPDHSITSFEEEPIKDFHEEDKVIEGTEI 1583
++ E V E + + ++E I E + E+ + + EE +++ E+ V E
Sbjct: 1383 EEVIPEVLVEEEVPEELVEEVIPEELVEEMLPEELIEVVVPEELVEEVVPEELVEEVVPE 1442
Query: 1582 VGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGANKDIGESSIKDV 1403
++ I + +I EE+VP+ I E + ++ E++IEE+ I E + +V
Sbjct: 1443 EVVEEVIPEELI-EELVPEVEIEEILPEELIEELIPEEIIEEV--------IPEELVAEV 1493
Query: 1402 VLDQSTTSI-GETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDHPTKTIGE-------- 1250
+ + + E V++ E V K+I E ++ E VV + K I E
Sbjct: 1494 IPGEIVEEVVPEELVEEVVPEEVVEEVIPKEIVEEVVSEEVVEEVIPKEIAEEVLSAQVF 1553
Query: 1249 -------IKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDK 1091
I ++ ++++E + V E S + EE E+
Sbjct: 1554 EEVIPKEIVEEEVPEELVEVAPEELVEEVVP---------EELSEEVVPEELV----EEV 1600
Query: 1090 VIEGLEIVDDVVPKPSTTITGEEAIRNGQEENKVIEELEIVDAEEDIGEPIIEKDVVPGH 911
V EGL V++VVP+ EE + E V+EE+E EE I E ++E ++VP
Sbjct: 1601 VPEGL--VEEVVPEELVVFLPEELVEEVVPE--VVEEVEEELVEEFIPEEVVE-ELVPEE 1655
Query: 910 TTTIGEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAHXXX 731
+ E+LI DV + V E + E VV++V+PE V E + +
Sbjct: 1656 L--VPEKLIEDVVPEEIVEEVLPEEVVKEVIPEEVVEEVLPEELVEEVVPEELVEEVIPE 1713
Query: 730 XXXXXXXIVGADKEIREPAIKEDVVPDLSTTTREEPIQDGHDINKVGEGLEIAGSDKDNG 551
E+ + E+V+P EE ++ + + E + ++
Sbjct: 1714 ELIA---------EVVSEQLVEEVLP-------EEVVEGSNPKGMLEEVIPEEVVEEVIP 1757
Query: 550 DPIIEEEVIPDHSTTIIGEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPNHSTT 371
I+EEEV P+ ++ EE + E+ V V+ V++ + E ++E+ VVP
Sbjct: 1758 KEIVEEEV-PEELVEVVPEELVEEVVPEELVEEVVPEELVEEVVPEELVEE-VVPEELVE 1815
Query: 370 TTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPITEKDVAPDNFIAAF-EEEAIKDVHEED 194
E + + +++E + ++ +++ E + +++ P+ I EE I++V E+
Sbjct: 1816 EVVPEELVEEVVPEELVEEVVPEEVVEEVEEEVEIEEILPEELIEELVTEEVIEEVIPEE 1875
Query: 193 KVIEETEIIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEEL 41
VIEE +++ ++ EE+VP+ E +Q+ E+ + EE+
Sbjct: 1876 -VIEEVIPEELVEEVIPELLVEEVVPEVV------EEVQEPLVEEFIPEEV 1919
Score = 117 bits (293), Expect = 3e-23
Identities = 250/1163 (21%), Positives = 481/1163 (41%), Gaps = 58/1163 (4%)
Frame = -1
Query: 3355 DPEKIGQMEDRDY-ENKEGVKMVTEETSLQKSEVEESWSPDNT----HSHLLDETSL-KP 3194
D E G E+ D EN E + V + T K VE+ +N H D +
Sbjct: 244 DEENKGIDENTDINENVEENEYVDKNTEGDKDGVEDKGGGENEGGDGHGSAGDSAGGDRG 303
Query: 3193 IDLQKERNDENATEPKIQDTKIMDIIGRVDIDDEEVPEQLEKDQPEMEQNDRKELPPEMK 3014
D K++++E + K G D DDEE E+ E D+ + E++D+ E + +
Sbjct: 304 GDENKDKDNEENKDKK----------GNKDDDDEEEEEEEEDDEEKEEKDDKDEKDEKDE 353
Query: 3013 HEDLDFKGNGAQDVDGTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGI 2834
++ D K E+ +G K E K +KEE K+ I
Sbjct: 354 KDEKDEKDEKD--------EKDEKGEKDESKGE--EKFLKEEKMPKKEENMQDK-----I 398
Query: 2833 ESSKEDNEAKKPEEEINEGLDIGGAEEDTGEHIVENDVILDHNRTTIQE-----EAIKDA 2669
E KE K EG G E G+ + R T+ E E + +
Sbjct: 399 ERDKEFEGFKDEYFTQMEGGAYGITVEHEGQKL----------RETLTEGVEGYEKVIEE 448
Query: 2668 HKEDKANEVLEIAGVGK-DDGETVMEEDVVPDPSTTTIGEEPTKDG----HEEDKVIEIS 2504
++ K +E L GK DD + MEE+ + + + EE KD E+ E+
Sbjct: 449 MEQTKLDEFLLPTNEGKSDDFVSEMEEERLFN--FVSYMEEEVKDKMFIEREQGTEEEVI 506
Query: 2503 KIDSVDKDIG-ESIIKENVVPDVSTTTIGEAQTKDVREEDKIIEGLNIDADEEVGDS--I 2333
D D+ IG E E V DVS + Q + + EE+K+ E + +E++ + +
Sbjct: 507 HEDLSDEKIGIEKKELETFVQDVSDEVL---QDEQLIEEEKLTEEEKLTEEEKLTEEEKL 563
Query: 2332 TKDVVQDQSTTTIGEETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGH- 2156
T++ + I EE + EEE+ T EE + +
Sbjct: 564 TEEEKLTEDEQLIEEEKLT---EEEK----------------------LTEEEKLTEEEK 598
Query: 2155 --EKEKIIEQPEIVGADREIREPV-IEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIA 1985
E+EK+ E+ ++ ++ E + IEED + EEP++D ++E +E
Sbjct: 599 LTEEEKLTEEEKLTEEEKLTEEEIFIEEDKISPKEV----EEPLED-----VLMEKME-- 647
Query: 1984 SSNKDNGDPTIEGEVVPNHSITTIGEESTNDGQEEDKVVAEL--DIVDVHKXXXXXXXXX 1811
K+ + EG+ V + E+ ++ E+D + E+ ++VD
Sbjct: 648 ---KEYKEILHEGKSVVTQDMD---EKLLSENLEDDLIPEEIIEELVD------------ 689
Query: 1810 XXXXDHSTTTIGEEPIQDGPAENKVIEGLEKVDLDEHIGEHITEKDVAPDHSITSFEEEP 1631
EE +++ AE V E + +V+++E I + + E +V P+ + E
Sbjct: 690 ------------EELVEEVTAEEIVEEFVVEVEIEEKIPKELVE-EVMPEEDVDEVVPEE 736
Query: 1630 IKDFHEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELK 1451
+ + E D+V+E ++ + EE++P+ + E + + +K++E +
Sbjct: 737 LVE--EPDEVVE---------EVTTEELTEEVIPEELIEKVVEEELVEKVVAQKIVEVIP 785
Query: 1450 IDGANKDIGESSIKDVVLDQSTTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDH 1271
+ + I E ++V+ + I E V++ E V+ +++ E +I E VV +
Sbjct: 786 EELIEEVITEKPAEEVIPELVEEVIPEEIVEEVLPEEVVKEVIPEEVVEEVIPEEVVEEV 845
Query: 1270 PTKTIGE------IKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTK 1109
P + + E +++ E+ E + + V + + EE +
Sbjct: 846 PEEIVEEVVPEELVEEMKPEEVFEEVISEELVEEMKPEEVVEEVTPEKVVEEVVPEELVE 905
Query: 1108 DGHEDKVIEGL---EIVDDVVPKPST-TITGEEAIRNGQEENKVIEELEIVDAEEDIGEP 941
+ ++V+E + E+V++V+P+ I EE + + E + + V+ EE I +
Sbjct: 906 EMKPEEVVEEVVPEELVEEVIPEEVVEEIIPEEVVHEAKHEELFEKLVPEVEVEEIIPKE 965
Query: 940 IIE---KDVVPGH--TTTIGEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEHST 776
++E ++V+P I EE+I +V +V+E E++ E +V +VIPE
Sbjct: 966 LVEVIPEEVLPEELIEEVIPEEIIEEVVIPEEVVE--EVI------PEEIVQEVIPEDLM 1017
Query: 775 TTSVGESIKDAHXXXXXXXXXXIVGADKEIREPAIKEDVVP-DLSTTTREEPIQDGHDIN 599
V E I + +EI + E+VVP ++ E+ +++
Sbjct: 1018 EEVVPEEIIEEKIPEEIVEEEIHEEIVEEIIPEEVVEEVVPAEVEEMIPEKIVEEVIPEE 1077
Query: 598 KVGEGLEIAGSDKDNGDPIIEEEVIPDHSTTIIGEESTNDGHEEDKVVAVLDIVGVDKDI 419
V E + + ++ ++EE + + +I E + E+ V V+ +++ I
Sbjct: 1078 LVEEVVPVEVLEEVVPVEVLEEVIPEEVVEEVIPVEVLEEVIPEEVVEEVIPEEFIEEMI 1137
Query: 418 GEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPITEKDVAPDNFI 239
E ++E+ VVP EE +++ + E + + L++ I E + E +V P+ +
Sbjct: 1138 PEEIVEE-VVPEVVEEVIPEELVEEVVPVELLEEVISEELLEEVIPEELVE-EVVPEELV 1195
Query: 238 AAFE-----EEAIKDVHEEDKVIEE--TEIIG---ADKDIGDHIIGEEIVPDHSTTTIRG 89
+ EE I +V E+ + EE E+I ++++ + ++ EE++P+ +
Sbjct: 1196 EEMKPEEVLEEVIPEVLVEEVIPEELVEEVIPEVLVEEEVPEELV-EEVIPELLVEEVVP 1254
Query: 88 EPIQDGHEE-------DKVTEEL 41
E +++ E+ ++V EEL
Sbjct: 1255 EVVEEVQEQLVEEFIPEEVVEEL 1277
Score = 94.0 bits (232), Expect = 3e-16
Identities = 191/869 (21%), Positives = 367/869 (42%), Gaps = 52/869 (5%)
Frame = -1
Query: 3196 PIDLQKERNDENATEPKIQDTKIMDIIGRVDIDDEEVPEQLEKDQPE--MEQNDRKELPP 3023
P+++ +E E E I + I ++I +I +E VPE +E+ PE +E+ EL
Sbjct: 1111 PVEVLEEVIPEEVVEEVIPEEFIEEMIPE-EIVEEVVPEVVEEVIPEELVEEVVPVELLE 1169
Query: 3022 EMKHEDLDFKGNGAQDVDGTPIEQINQGSKMVQVTE-VTHKDIKEEGCDFKDLGTISTGE 2846
E+ E+L + + V+ E++ + K +V E V + + EE + + +
Sbjct: 1170 EVISEELLEEVIPEELVEEVVPEELVEEMKPEEVLEEVIPEVLVEEVIPEELVEEVIPEV 1229
Query: 2845 LAGIESSKEDNEAKKPE-----------EEINEGLDIGGAEEDTGEHIVENDVILDHNRT 2699
L E +E E PE EE+ E L E+ E +V +++ +
Sbjct: 1230 LVEEEVPEELVEEVIPELLVEEVVPEVVEEVQEQLVEEFIPEEVVEELVPEELVEEVIPE 1289
Query: 2698 TIQEEAIKDAHKEDKANEVLEIAGVGKDDGETVMEEDVVPDPSTTTIGEEPTKDGHEEDK 2519
I EE +++ +E EV+E G ++ + E+V+P EE ++ E+
Sbjct: 1290 EIVEEVVEEVVEEIIPEEVIEEVRPGPEE----LVEEVIP--------EELVEEVIPEEL 1337
Query: 2518 VIEISKIDSVDKDIGESIIKENVVPDVSTTTIGEAQTKDVREEDKIIEGL-NIDADEEVG 2342
V E+ + V++ I E +++E VVP+V + E ++V E+ + E + + +EEV
Sbjct: 1338 VAEVIPEELVEEVIPEELVEE-VVPEVVEEVVPEELVEEVIPEELVEEVIPEVLVEEEVP 1396
Query: 2341 DSITKDVVQDQSTTT-IGEETIKCGHEEE--RELXXXXXXXXXXXXXXXXXAVPATGEEP 2171
+ + ++V+ ++ + EE I+ EE E+ +P E
Sbjct: 1397 EELVEEVIPEELVEEMLPEELIEVVVPEELVEEVVPEELVEEVVPEEVVEEVIPEELIEE 1456
Query: 2170 IKDGHEKEKIIEQPEIVGA-DREIREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGL 1994
+ E E+I+ + I EI E VI E++V ++ EE + + V E +
Sbjct: 1457 LVPEVEIEEILPEELIEELIPEEIIEEVIPEELVAEVIPGEIVEEVVPEELVEEVVPEEV 1516
Query: 1993 EIASSNKDNGDPTIEGEVVPNHSITTIGEESTNDGQEEDKVVAELDIVDVHKXXXXXXXX 1814
K+ + + EVV I EE + E+ + E+ +V +
Sbjct: 1517 VEEVIPKEIVEEVVSEEVVEEVIPKEIAEEVLSAQVFEEVIPKEIVEEEVPEELVEVAPE 1576
Query: 1813 XXXXXDHSTTTIGEEPIQDGPAENKVIEGLEKVDLDEHIGEHITEK---DVAPDHSITSF 1643
+ EE + + E V EGL + + E + + E+ +V P+ +
Sbjct: 1577 ELVEEV-VPEELSEEVVPEELVEEVVPEGLVEEVVPEELVVFLPEELVEEVVPE-VVEEV 1634
Query: 1642 EEEPIKDFHEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVI 1463
EEE +++F E+ V E + + + ++ EEIV + + E I ++ EE +
Sbjct: 1635 EEELVEEFIPEEVVEELVPEELVPEKLIEDVVPEEIVEEVLPEEVVKEVIPEEVVEEVLP 1694
Query: 1462 EELKIDGANKDIGESSIKDVVLDQSTTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENV 1283
EEL + +++ E I + ++ + + E V++ E V K + E +I E V
Sbjct: 1695 EELVEEVVPEELVEEVIPEELIAEV---VSEQLVEEVLPEEVVEGSNPKGMLEEVIPEEV 1751
Query: 1282 VLDHPTKTIGEIKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDG 1103
V + K EI ++ ++++E + + V E + EE ++
Sbjct: 1752 VEEVIPK---EIVEEEVPEELVEVVPEELVEEVVPEELVEEVVPEELVEEVVPEELVEEV 1808
Query: 1102 HEDKVIEGL---EIVDDVVPKPSTT-ITGEEAIRNGQEE--------NKVIEEL---EIV 968
++++E + E+V++VVP+ + EE + +EE ++IEEL E++
Sbjct: 1809 VPEELVEEVVPEELVEEVVPEELVEEVVPEEVVEEVEEEVEIEEILPEELIEELVTEEVI 1868
Query: 967 DA-------EEDIGEPIIEK--------DVVPGHTTTIGEELINDVHDDNKVIEGFEMVG 833
+ EE I E ++E+ +VVP + E L+ + + V E
Sbjct: 1869 EEVIPEEVIEEVIPEELVEEVIPELLVEEVVPEVVEEVQEPLVEEFIPEEVVKE------ 1922
Query: 832 SDKDTGEPVVDDVIPEHSTTTSVGESIKD 746
E +V++VIPE V E +++
Sbjct: 1923 ---LVPEELVEEVIPEEIVEEVVEEVVEE 1948
Score = 80.5 bits (197), Expect = 4e-12
Identities = 139/622 (22%), Positives = 260/622 (41%), Gaps = 44/622 (7%)
Frame = -1
Query: 1741 KVIEGLEKVDLDEHI--------GEHITEKDVAPDHSITSFEEEPIKD--FHEEDKVIEG 1592
KVIE +E+ LDE + + ++E + + S+ EE +KD F E + +G
Sbjct: 444 KVIEEMEQTKLDEFLLPTNEGKSDDFVSEMEEERLFNFVSYMEEEVKDKMFIERE---QG 500
Query: 1591 TEIVGADKDIGDPIIG------EEIVPDHSTTTIRGEPIQDDH---EEEKVIEELKIDGA 1439
TE +D+ D IG E V D S ++ E + ++ EEEK+ EE K+
Sbjct: 501 TEEEVIHEDLSDEKIGIEKKELETFVQDVSDEVLQDEQLIEEEKLTEEEKLTEEEKLTEE 560
Query: 1438 NKDIGESSIKDVVLDQSTTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDHPTKT 1259
K E + + +Q T + EE K+ E + +E + + T
Sbjct: 561 EKLTEEEKLTED--EQLIEEEKLTEEEKLTEEEKLTEEEKLTEEEKLTEEEKLTEEEKLT 618
Query: 1258 IGEI---KDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKV 1088
EI +DK +V E L++ + + T+ E+ + ED +
Sbjct: 619 EEEIFIEEDKISPKEVEEPLEDVLMEKMEKEYKEILHEGKSVVTQDMDEKLLSENLEDDL 678
Query: 1087 IEGLEIVDDVVPKPSTT-ITGEEAIRNG----QEENKVIEEL-EIVDAEEDIGEPIIEK- 929
I EI++++V + +T EE + + E K+ +EL E V EED+ E + E+
Sbjct: 679 IPE-EIIEELVDEELVEEVTAEEIVEEFVVEVEIEEKIPKELVEEVMPEEDVDEVVPEEL 737
Query: 928 -----DVVPGHTT------TIGEELINDVHDDNKVIEGFEMVGSDKDTG---EPVVDDVI 791
+VV TT I EELI V ++ V E V + K E ++++VI
Sbjct: 738 VEEPDEVVEEVTTEELTEEVIPEELIEKVVEEELV----EKVVAQKIVEVIPEELIEEVI 793
Query: 790 PEHSTTTSVGESIKDAHXXXXXXXXXXIVGADKEIREPAIKEDVVPDLSTTTREEPIQDG 611
E + E +++ + I E ++E + ++ EE +++
Sbjct: 794 TEKPAEEVIPELVEEVIPEEIVEEVLPEEVVKEVIPEEVVEEVIPEEVVEEVPEEIVEE- 852
Query: 610 HDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHSTTIIGEESTNDGHEEDKVVAVLDIVGV 431
V E L ++ + +I EE++ + + EE T + E+ V L V
Sbjct: 853 ----VVPEELVEEMKPEEVFEEVISEELVEEMKPEEVVEEVTPEKVVEEVVPEEL----V 904
Query: 430 DKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPITEKDVAP 251
++ E V+E+ VVP E + + +V+ + +L + + + +++ P
Sbjct: 905 EEMKPEEVVEE-VVPEELVEEVIPEEVVEEIIPEEVVHEAKHEELFEKLVPEVEVEEIIP 963
Query: 250 DNFIAAFEEEAIKDVHEEDKVIEET-EIIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQD 74
+ EE + + E+ + EE E + +++ + +I EEIV + + E + +
Sbjct: 964 KELVEVIPEEVLPEELIEEVIPEEIIEEVVIPEEVVEEVIPEEIVQEVIPEDLMEEVVPE 1023
Query: 73 GHEEDKVTEELKIDGAKKDIGE 8
E+K+ EE+ + ++I E
Sbjct: 1024 EIIEEKIPEEIVEEEIHEEIVE 1045
Score = 77.4 bits (189), Expect = 3e-11
Identities = 129/673 (19%), Positives = 279/673 (41%), Gaps = 12/673 (1%)
Frame = -1
Query: 3262 EVEESWSPDNTHSHLLDETSLKPIDLQKERNDENATEPKIQDTKIMDIIGRVDIDDEEVP 3083
EV E + +++E P +L +E E E I + + ++I ++ +E +P
Sbjct: 1294 EVVEEVVEEIIPEEVIEEVRPGPEELVEEVIPEELVEEVIPEELVAEVIPE-ELVEEVIP 1352
Query: 3082 EQL-EKDQPEMEQNDRKELPPEMKHEDLDFKGNGAQDVDGTPIEQINQGSKMVQVTEVTH 2906
E+L E+ PE+ + E+ PE E++ P E + + V V E
Sbjct: 1353 EELVEEVVPEVVE----EVVPEELVEEV------------IPEELVEEVIPEVLVEEEVP 1396
Query: 2905 KDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPEEEINEGLDIGGAEEDTGEHIVEN 2726
+++ EE + + + EL + +E E PEE + E + EE E ++E
Sbjct: 1397 EELVEEVIPEELVEEMLPEELIEVVVPEELVEEVVPEELVEEVVPEEVVEEVIPEELIEE 1456
Query: 2725 DVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKDDGETVMEEDVVPDPSTTTIGEEP 2546
V + EE I++ E+ EV+ V + ++EE V + + EE
Sbjct: 1457 LVPEVEIEEILPEELIEELIPEEIIEEVIPEELVAEVIPGEIVEEVVPEELVEEVVPEEV 1516
Query: 2545 TKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDV-STTTIGEAQTKDVREEDKIIEGL 2369
++ ++ V E+ V +++ E +I + + +V S E K++ EE+ E +
Sbjct: 1517 VEEVIPKEIVEEV-----VSEEVVEEVIPKEIAEEVLSAQVFEEVIPKEIVEEEVPEELV 1571
Query: 2368 NIDADEEVGDSITKDVVQDQSTTTIGEETIKCGHEEERELXXXXXXXXXXXXXXXXXAVP 2189
+ +E V + + +++ ++ + EE + G EE V
Sbjct: 1572 EVAPEELVEEVVPEELSEEVVPEELVEEVVPEGLVEEVVPEELVVFLPEELVEEVVPEVV 1631
Query: 2188 ATGEEPIKDGHEKEKIIEQ-------PEIVGAD---REIREPVIEEDVVPDLSTTTTREE 2039
EE + + E+++E+ PE + D EI E V+ E+VV ++ EE
Sbjct: 1632 EEVEEELVEEFIPEEVVEELVPEELVPEKLIEDVVPEEIVEEVLPEEVVKEVIPEEVVEE 1691
Query: 2038 PIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVVPNHSITTIGEESTNDGQEEDKVVAEL 1859
+ + +++E + ++ + EVV + + E +G ++ E+
Sbjct: 1692 VLPE-----ELVEEVVPEELVEEVIPEELIAEVVSEQLVEEVLPEEVVEGSNPKGMLEEV 1746
Query: 1858 DIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAENKVIEGLEKVDLDEHIGEHITE 1679
+V + + + EE +++ E V E + + ++E + E + E
Sbjct: 1747 IPEEVVEEVIPKEIVEEEVPEELVEVVPEELVEEVVPEELVEEVVPEELVEEVVPEELVE 1806
Query: 1678 KDVAPDHSITSFEEEPIKDFHEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGE 1499
+V P+ + E + + ++++E +++ + + EEI+P+ + E
Sbjct: 1807 -EVVPEELVEEVVPEELVEEVVPEELVEEVVPEEVVEEVEEEVEIEEILPEELIEELVTE 1865
Query: 1498 PIQDDHEEEKVIEELKIDGANKDIGESSIKDVVLDQSTTSIGETPVKDAHEEHKVRVGAN 1319
+ ++ E+VIEE+ + +++ + + V+ + + E V++ E V+
Sbjct: 1866 EVIEEVIPEEVIEEVIPEELVEEVIPELLVEEVVPEVVEEVQEPLVEEFIPEEVVKELVP 1925
Query: 1318 KDIGEPIIKENVV 1280
+++ E +I E +V
Sbjct: 1926 EELVEEVIPEEIV 1938
>ref|XP_001348162.2| Antigen 332, DBL-like protein [Plasmodium falciparum 3D7]
gi|254832737|gb|AAN36075.2| Antigen 332, DBL-like protein
[Plasmodium falciparum 3D7]
Length = 6093
Score = 137 bits (345), Expect = 3e-29
Identities = 300/1474 (20%), Positives = 593/1474 (40%), Gaps = 112/1474 (7%)
Frame = -1
Query: 4111 SEDKVKPILTKTQEPESERQMQKDQTNDTVEATGDIIKGDKIDSCGEH--ALKKMSLDSA 3938
+++KV+ + E E+ + ++ + T ++KG + E ++ + L+
Sbjct: 1441 NDEKVEVASITEEVEEEEKSVSEEVLEEEGSTTEKVVKGSSTEVVVEEQGSVTENLLEEE 1500
Query: 3937 RADNVGLVNSSALSTAPND--DDNIGEKLPAVPITSVSDDLNVQEGQTEGGNGADMDDME 3764
A G+V + D N+ EK + +V E E G +D E
Sbjct: 1501 SASQ-GIVEKEEFVDEEDSVKDQNVFEK-----------EGSVTEQLVEEEKGLINEDNE 1548
Query: 3763 QKNDVI-FDDKQAPVVEHLQSGDIIRHHLVGNSKEVNGDQLTEGICASQSIEEDKAVTSS 3587
++ + ++ V E ++ D+ ++ +G+ + +EE+K++T
Sbjct: 1549 KEELITEMSEEIKSVNEEIEETDLSTEEIIKQ----------QGLATYEFVEEEKSLTDK 1598
Query: 3586 HEDQTEGTESGEDPDLKSGXXXXXXXXXXXEYYDKEKVVADDLYTHNISIEEVKQSG--- 3416
++ T+ + +L + E ++EK V++++ + EEV + G
Sbjct: 1599 LLEEESVTKEVGETELSTQEVVDEKVSVTEEVIEEEKSVSEEVLEEGSATEEVVEEGSCT 1658
Query: 3415 -FQEKELECKEQSSNSMGMVKDPEKIGQMEDRDYENKEGVKMVTEETSLQKSEVEESWSP 3239
+E C E + + G + E ++V EE S + VEE +
Sbjct: 1659 EVVVEEGSCTEVVVEEGSCTEIVVEKGSDTEIVVEEGSATEIVVEEGSATEVVVEEGSAT 1718
Query: 3238 DNTHSHLLDETSLKPIDLQKERN-DENATEPKIQDTKIMDIIGRVDIDDEEVPEQLEKDQ 3062
+ +++E S+ L++E + E E + + G ++ E + KD+
Sbjct: 1719 EE----VVEEGSVSEEMLEEEGSATEEVVEEGLSSDNVQKSKGVIENVGEIYSVKTAKDE 1774
Query: 3061 PEMEQNDRKELPPEMKHEDLDFKGNGAQDVDGTPIEQINQGSKMVQVTEVTHKDIKEEGC 2882
N++ L +D FKG G D +E +N + + T + I+E
Sbjct: 1775 ---SMNEKIPLEKSSFVDDESFKGQGP--TDNVSVEDVNSEDIINEHTPLEETKIEELPT 1829
Query: 2881 DFKDLGTIST-GE------LAGIESSKEDNEAKKPEEEINEGLDIGGAEEDTGEHIVEND 2723
++ I T GE L + ++E +AK EE+I E + + E E IV+
Sbjct: 1830 EYITTADIHTKGETETKYNLIYEKINEEVEKAKFQEEKITENIPV--ERESVTEDIVQEP 1887
Query: 2722 VILDHNRTTIQEEAIKDAHKEDK-ANE-----------VLEIAGVGKDDGETVMEEDVVP 2579
+ Q+E+ + +E K ANE V+E G+ D E V+EED
Sbjct: 1888 SLAQEVE---QKESDTNEIEETKLANEKIIPEVSVTENVVEKEGL---DTEEVLEED--- 1938
Query: 2578 DPSTTTIGEEPTKDGHE--EDKVIEISKIDSVDKDIGESIIKENVVPDVSTTTIGEAQTK 2405
+ T I EE E E++ +I ++ E I++E E+ ++
Sbjct: 1939 ESITEEIVEEEVSSSEEIVEEEESSSEEIVEEEESSSEEIVEEEESSSEEIVEEEESSSE 1998
Query: 2404 DVREEDK-----IIEGLNIDADEEVGD---SITKDVVQDQSTTTIGEETIKCGHEEEREL 2249
++ EE++ IIE + + EEV + S+T+++V+++ +TT EE G E L
Sbjct: 1999 EIVEEEESSSEEIIE--EVSSTEEVLEEEGSVTEEIVEEEVSTT--EEVKDIGSVSEEVL 2054
Query: 2248 XXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQPEIVGADRE--IRE--PVIEE 2081
EE ++ EK++E VG++ E ++E PV +E
Sbjct: 2055 EEEGFGTEEFVGQQGSVI-----EEIVETESSTEKVLED---VGSNVEEIVQEEGPVAQE 2106
Query: 2080 DVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVVPNHSITTIGEES 1901
V ++STT +E D +++E + S + + E+V S+T
Sbjct: 2107 IVHEEVSTTEKHDEV--DRSTTEEIVEKVGSVSEEIIVEEVSASEEIVEEGSVT------ 2158
Query: 1900 TNDGQEEDKVVAEL-DIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAENKVI--E 1730
+ EE+K++ E+ + V + ++ EE ++ +++ E
Sbjct: 2159 -EEVVEEEKLINEVGETESVTEEIVQKEVSDAEEVLGQEGSMNEEILEKESIVEEIVGPE 2217
Query: 1729 GLEKVDLDEH--IGEHITEKDVAPDHSITSFEEEPIKDFHEEDKVIEG--------TEIV 1580
G ++ +H E + E+++ + ++ +E ++ EE+ + E EI+
Sbjct: 2218 GSVTEEIVDHGSFAEEVKEEELVTEEAV-QYEGSVTEEIKEEESITENEAIEESAFAEII 2276
Query: 1579 GADKDIGDPIIGEEIVPDH---STTTIRGEPIQDDH--EEEKVIEELKIDGANKDIGESS 1415
D I+ EE + + ++ E I+++ E+ V EE + ++ S+
Sbjct: 2277 EEKGPNTDEIVKEEGLDTEEIVNEVSVTDEVIEEEKLVNEQIVGEERSVTEKPVEVERSA 2336
Query: 1414 IKDVVLDQSTTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLD----HPTKTIGEI 1247
+D+V ++++ T HE ++ + E I++E V +D ++ E+
Sbjct: 2337 TEDLVEEEASV----TEKVSVHEGSTTEQILDESVAEEIVEEEVSVDDKIIEEEVSVDEV 2392
Query: 1246 KDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVIEGLE-- 1073
+ EE VIE + + + G E + W G E VIE +E
Sbjct: 2393 VE--EEGSVIEEIVEEEESVPEEILEEELSG-SEEVLEDEWVTDAFMGQEGSVIEEIEEI 2449
Query: 1072 ----------IVDD-------VVPKPSTT--ITG------EEAIRNGQ------------ 1004
IV+D V +PS + G EE I G
Sbjct: 2450 VDGEGSITEEIVEDGSANEKIVEEEPSRVEEVLGKEGFVIEEIIEEGSVIEQVEDTKTVS 2509
Query: 1003 ---EENKVIEELEIVDAEEDIGEPIIEKDVVPGHTTTIGEELI-NDVHDDNKVIEGFEMV 836
EE+ IEE++ V EE I E I+EK+ ++ EE++ + K+++
Sbjct: 2510 EKSEESSAIEEVKEVKEEESISEKIVEKE------ESVTEEIVRQEESTTEKIVKDVSPT 2563
Query: 835 GSDKDTGEPVVDDVIPEHSTTTSVGESIKDAH-XXXXXXXXXXIVGADKEIREPAIKEDV 659
+ + V + VI + + T V E +++ V A + ++ +++
Sbjct: 2564 EDFVEQTDSVTEKVIEQEGSNTEVAEDVEEKESASDEHEQEDVSVNAQVTYEKKSVTKEI 2623
Query: 658 VPDLSTTTREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHSTTIIGEESTND 479
V ++S T EE +++ V EG++ GS + EE+I + + T EE D
Sbjct: 2624 VDEVSRT--EEIVEEN---GSVTEGVDETGS--------VTEEIIEEATVT---EEVVED 2667
Query: 478 GHEEDKVV---AVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLE 308
G ++VV +V+ V D + E ++++N + EE +++ + N+ +E
Sbjct: 2668 GSVTEEVVEDGSVIQEVVEDGSVTEEIVQEN-------GSVTEEIVEEEGSVNEEVEEEV 2720
Query: 307 KVDLDKDIGEPITEKDVAPDNFIAAFEEEAIKDVHEEDKVIEETEIIGADKDIGDHIIGE 128
V + D E +TE+ + + EE +++ ++ETE + + + ++ E
Sbjct: 2721 SVSGEVDETEYVTEEVEEEGSVV----EEIVEEEGSVSGEVDETEYVTEEVEEEGSVV-E 2775
Query: 127 EIVPDHSTTTIRGEPIQDGHEEDKVTEELKIDGA 26
EIV + ++ GE E + VTEE++ +G+
Sbjct: 2776 EIVEEEG--SVSGEV----DETEYVTEEVEEEGS 2803
Score = 137 bits (344), Expect = 3e-29
Identities = 309/1509 (20%), Positives = 629/1509 (41%), Gaps = 179/1509 (11%)
Frame = -1
Query: 4015 TGDIIKGDKIDSCGEHALKKMSLDSARADNVGLVNSS------ALSTAPNDDDNIGEKLP 3854
T +I+K + +D+ E + ++S+ + LVN +++ P + + +
Sbjct: 2283 TDEIVKEEGLDT--EEIVNEVSVTDEVIEEEKLVNEQIVGEERSVTEKPVEVERSATEDL 2340
Query: 3853 AVPITSVSDDLNVQEGQT-EGGNGADMDDMEQKNDVIFDDK----QAPVVEHLQSGDIIR 3689
SV++ ++V EG T E + + + +V DDK + V E ++ +
Sbjct: 2341 VEEEASVTEKVSVHEGSTTEQILDESVAEEIVEEEVSVDDKIIEEEVSVDEVVEEEGSVI 2400
Query: 3688 HHLVGNSKEVNGDQLTEGICASQSIEEDKAVTSSHEDQTEGTESGEDPDLKSGXXXXXXX 3509
+V + V + L E + S+ + ED+ VT + Q EG+ E ++ G
Sbjct: 2401 EEIVEEEESVPEEILEEELSGSEEVLEDEWVTDAFMGQ-EGSVIEEIEEIVDGEGSITEE 2459
Query: 3508 XXXXEYYDKEKVVADD-------LYTHNISIEEVKQSGFQEKELEC------KEQSSNSM 3368
+ EK+V ++ L IEE+ + G +++E K + S+++
Sbjct: 2460 IVEDGSAN-EKIVEEEPSRVEEVLGKEGFVIEEIIEEGSVIEQVEDTKTVSEKSEESSAI 2518
Query: 3367 GMVKDPEKIGQMEDRDYENKEGV--KMVTEETSLQKSEVEESWSPDNTHSHLLDETSLKP 3194
VK+ ++ + ++ E +E V ++V +E S + V++ SP D + K
Sbjct: 2519 EEVKEVKEEESISEKIVEKEESVTEEIVRQEESTTEKIVKDV-SPTEDFVEQTDSVTEKV 2577
Query: 3193 IDLQKERND--------ENATEPKIQDT----------------KIMDIIGRVDIDDEE- 3089
I+ + + E+A++ Q+ +I+D + R + EE
Sbjct: 2578 IEQEGSNTEVAEDVEEKESASDEHEQEDVSVNAQVTYEKKSVTKEIVDEVSRTEEIVEEN 2637
Query: 3088 --VPEQLEKDQPEMEQNDRKELPPEMKHEDLDFKGNGAQDV--DGTPIEQI-NQGSKMVQ 2924
V E +++ E+ + E ED G+ ++V DG+ I+++ GS +
Sbjct: 2638 GSVTEGVDETGSVTEEIIEEATVTEEVVED----GSVTEEVVEDGSVIQEVVEDGSVTEE 2693
Query: 2923 VTE----VTHKDIKEEGCDFKDLG--TISTGELAGIESSKED--NEAKKPEEEINEGLDI 2768
+ + VT + ++EEG +++ +GE+ E E+ E EE + E +
Sbjct: 2694 IVQENGSVTEEIVEEEGSVNEEVEEEVSVSGEVDETEYVTEEVEEEGSVVEEIVEEEGSV 2753
Query: 2767 GGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKDDGETVMEED 2588
G ++T E++ E ++ + ++E ++ + +E + +++G +V+EE
Sbjct: 2754 SGEVDET-EYVTEE---VEEEGSVVEEIVEEEGSVSGEVDETEYVTEEVEEEG-SVVEEI 2808
Query: 2587 VVPDPS-------TTTIGEEPTKDGHEEDKVIE-----ISKIDSVDKDIGESIIKENVVP 2444
V + S T + EE ++G ++++E + +I + + E + + +V
Sbjct: 2809 VEEEGSVSGEVDETEYVTEEVEEEGSVVEEIVEEEGSVVEEIVEEEGSVSEVVDETELVN 2868
Query: 2443 D--VSTTTIGEAQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCG 2270
D V E + V D+IIE ++ E +SIT+ V Q++ T E+
Sbjct: 2869 DEIVEQAPFTEEVEEQVSVNDEIIEDASVAEAVEESESITESVSQEEET----EKGFVIE 2924
Query: 2269 HEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQPEIVGADREIREPV 2090
EE A EE ++DG E+I+E+ E V + +E
Sbjct: 2925 KVEE---------------------TGAVTEEIVQDGLITEEILEESESVNGEIINKESD 2963
Query: 2089 IEEDVVPDLSTT-------TTREEPIQDGHDINKVIEGLE-IASSNKDNGDPTIEGEVVP 1934
EE + + T +T EE +++ + K +E E + D G ++ E+V
Sbjct: 2964 AEEILETEFLTEEVVGQAGSTSEEIVEEEGSVTKEVEEKESVTEELVDEG--SVTEELVD 3021
Query: 1933 NHSIT--------TIGEESTNDGQEEDKVVA-ELDIVDVHKXXXXXXXXXXXXXDHSTTT 1781
S+T +I +E + ++++ E ++ +V + +
Sbjct: 3022 EGSVTEEVVEQGGSIAQEIVEEESATEEIIRDETNVEEVLEKEGSATEEIVQDGSGTNDF 3081
Query: 1780 IG------EEPIQD--GPAENKVIE---GLEKVDLDEHIGEH------ITEKDVAPDHSI 1652
+G EE +++ E K+ E +E+ +E I E +TE V S+
Sbjct: 3082 VGKQGSVIEEVVEEEISTTEEKLKEEASAIEEFVEEESIREDVLEESLVTENVVGQQESV 3141
Query: 1651 T--------SFEEEPIKDFHEEDKVIEGTEIVGADKDI------GDPIIGEEIVPDHSTT 1514
T SF E+ ++ EE+ V E EIV ++ + + ++ EEIV D +
Sbjct: 3142 TEEIVDGEGSFTEDIVE---EEESVTE--EIVVDEESVTKEIVEDEELVTEEIVEDEGSF 3196
Query: 1513 TIRGEPIQDDH--------EEEKVIEELKIDG--ANKDIGESSIKDVVLDQSTTSIGETP 1364
T E I +D EE +IEE++ A K+ G S IK+++ ++S T
Sbjct: 3197 T---EEIVEDEGSFTEEVIEERSLIEEVEDTETVAEKEEG-SVIKEIIDEKSLTEKIVEE 3252
Query: 1363 VKDAHEEHKVRVGANKDIGEPIIKENVVLDHPTKTIGEIKDKHEEDKVIEGL-------- 1208
K EE + + +++ E + VV + + T G ++D+ + +++ +
Sbjct: 3253 EKSVTEEVEEKESVKEEVEE---QRLVVEEEGSATEGIVEDRLATEGIVDDILVTEEIVE 3309
Query: 1207 DNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGH-EDKVIEGLEIV---DDVVPKPST 1040
D + V + T E ++G ++++EG+ ++ D++ P
Sbjct: 3310 DGLATDEFVEQQGSIIEEVLDDEGSVTEEIVEEEGSPNEEIVEGVSVIEEDDNIEPVSEE 3369
Query: 1039 TITG---EEAIRNGQEENKVIEE----LEIVDAEEDIGEPIIEK-----DVVPGHTTTIG 896
+ G EE I+ G E +++E E ++ E + E I+E+ + + +
Sbjct: 3370 IVEGSVTEEMIKEGLENEVILDEDSITEEALEKEGSVSEEIVEEMGSLTEEIVDEERSTS 3429
Query: 895 EELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEHS-TTTSVGESIK-DAHXXXXXX 722
E++I + ++I+ V + V+D+++ E T V E I+ +
Sbjct: 3430 EDMIEEGSASEEIIQEESQV-EEVVEEVSVIDEIVEEDELDTKEVVEEIEFNTEEVVEHK 3488
Query: 721 XXXXIVGAD--KEIREPAIKEDVVPDLSTTTREEPIQDGHDINKVGEGLEIAGSDKDNG- 551
V + +E +E ++ E+++ ++ + T E QD D ++ E + ++N
Sbjct: 3489 EEEGSVAEEIVQEEKEGSVNEEIIEEVGSITEEMVEQDVSDNEEIVEERSVIEEAEENVW 3548
Query: 550 -DPIIEEEVIPDHSTTIIGEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIED---NVVPN 383
+ +EEE + + +I EE + E++V +I+ D+ + +E+ N N
Sbjct: 3549 IEKEVEEEGLDNEE--VIDEEDSVSEQAEEEVYINEEILKESSDVEDVKVENELMNEEVN 3606
Query: 382 HSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPITEKDVAPDNFIAAFEEEAIKD-- 209
T + E +D + +N V+E E V + + E K+V I + EE ++D
Sbjct: 3607 EETQSVAENNEEDKELDNYVVEETESVTEEVVVDEVPNSKEVQE---IESIIEEIVEDGL 3663
Query: 208 -----VHEEDKVIEE-TEIIGADKD--IGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDKV 53
V ++ VIEE E +G+D + + + I EE+ S T +D E+ V
Sbjct: 3664 TTDDLVGQQGSVIEEVVEEVGSDSEEIVEEASITEEVEKKESVT-------EDILVEESV 3716
Query: 52 TEELKIDGA 26
T ++ ++G+
Sbjct: 3717 TGDILVEGS 3725
Score = 127 bits (319), Expect = 3e-26
Identities = 305/1530 (19%), Positives = 605/1530 (39%), Gaps = 169/1530 (11%)
Frame = -1
Query: 4114 DSEDKVKPILTKTQEPESERQMQKDQTNDTVEATGDIIKGDKID---SCGEHALKKMS-- 3950
+ +D ++P+ + E +M K+ + V D I + ++ S E +++M
Sbjct: 3358 EEDDNIEPVSEEIVEGSVTEEMIKEGLENEVILDEDSITEEALEKEGSVSEEIVEEMGSL 3417
Query: 3949 ----LDSARADNVGLVNSSALSTAPNDDDNIGEKLPAVPITSVSDDLNVQEGQTEGGNGA 3782
+D R+ + ++ + S +++ E++ V SV D++ ++
Sbjct: 3418 TEEIVDEERSTSEDMIEEGSASEEIIQEESQVEEV--VEEVSVIDEIVEED--------- 3466
Query: 3781 DMDDMEQKNDVIFDDKQAPVVEHLQSGDIIRHHLVGNSKE-------------VNGDQLT 3641
++D E ++ F+ ++ VVEH + + +V KE + + +
Sbjct: 3467 ELDTKEVVEEIEFNTEE--VVEHKEEEGSVAEEIVQEEKEGSVNEEIIEEVGSITEEMVE 3524
Query: 3640 EGICASQSIEEDKAVTSSHEDQTEGTESGEDPDLKSGXXXXXXXXXXXEYYDKEKVVADD 3461
+ + ++ I E+++V E+ + E+ L + E ++E + ++
Sbjct: 3525 QDVSDNEEIVEERSVIEEAEENVWIEKEVEEEGLDN-EEVIDEEDSVSEQAEEEVYINEE 3583
Query: 3460 LYTHNISIEEVKQSGFQEKELECKEQSSNSMGMVKDPEKIGQMEDRDYENKEGV------ 3299
+ + +E+VK E EL +E + + + ++ E+ ++++ E E V
Sbjct: 3584 ILKESSDVEDVKV----ENELMNEEVNEETQSVAENNEEDKELDNYVVEETESVTEEVVV 3639
Query: 3298 ------KMVTEETSLQKSEVEESWSPDNT------------------HSHLLDETSLKPI 3191
K V E S+ + VE+ + D+ +++E S+
Sbjct: 3640 DEVPNSKEVQEIESIIEEIVEDGLTTDDLVGQQGSVIEEVVEEVGSDSEEIVEEASITEE 3699
Query: 3190 DLQKERNDENATEPK-------IQDTKIMDIIGRVDIDDEEV--------PEQLEKDQPE 3056
+KE E+ + ++ + +++G + EE+ E +E+D P
Sbjct: 3700 VEKKESVTEDILVEESVTGDILVEGSVTEEVVGEEKLVSEEIVTEEGSVAQEIVEEDAPA 3759
Query: 3055 MEQNDRKELPPEMKHEDLDFKGNGAQDVDGTPIEQINQGSKMVQVTEVTHKDIKEEGCDF 2876
E+ D E E E+ +G+ E+I QG V+ ++E+G +
Sbjct: 3760 TEEIDEIESVTEEVVEEEGPVDEEIVQEEGSVTEEIIQGESKVEEV------VEEQGSEN 3813
Query: 2875 KDLGTISTGELAGIESSKEDNEAKKPEEEINEGLDIGGAEEDTGEHIVENDVILDHNRTT 2696
+++ + + +S+E + + EEI E + ++E + V +I + T
Sbjct: 3814 EEIF------VEEVSASQEIVQNESGTEEILE--KVSASQEIVQDGSVTEQIIEEQKPVT 3865
Query: 2695 IQEEAIKDAHKEDKANEVL-EIAGVGKDDGETVMEEDVVPDPSTTT---------IGEEP 2546
EE + + +E +E++ E + V K + + E+VV +P + T + E+
Sbjct: 3866 --EEVVNE--EESITHEIIQEESHVEKVVQQGSVAEEVVENPVSVTEEIVEKEGSVTEDI 3921
Query: 2545 TKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDVSTTTIGEAQTKD---VREEDKIIE 2375
++G+ ++++E + D+ + ES+ +E V I Q D V+EE+ + E
Sbjct: 3922 GQEGYVAEEIVEEEEFDNEEILEEESVAEEFVEEGFDNEEIFVEQISDSEIVKEENSVNE 3981
Query: 2374 ------GLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCGHEEERELXXXXXXXXXXXX 2213
G + E S T+++++++ + T EE + EEE
Sbjct: 3982 EVLEEEGSYTEEILEEEGSYTEEILEEEGSFT--EEIL----EEEGSYNEEILEEEGSYN 4035
Query: 2212 XXXXXAVPATGEEPIKD-GHEKEKIIEQPE-----IVGADREIREPVIEEDVVPD--LST 2057
+ EE +++ G E+I+E+ VG + E +IEE D +
Sbjct: 4036 EEILEEEGSYNEEILEEEGSYNEEILEEEGSATDYFVGQGSD-NEEIIEEGSATDYFVGQ 4094
Query: 2056 TTTREEPIQDGHDINKVI------------EGLEIASSNKDNGDPTIEGEVVPNHSITTI 1913
+ EE I++G + + EGL+ ++ G T E S T +
Sbjct: 4095 GSDNEEIIEEGSATDYFVGQGSIIEEVLEEEGLDTEKVFENEGSAT---EFEETESFTEV 4151
Query: 1912 GEE--STNDGQEEDKVVAELDIVD--VHKXXXXXXXXXXXXXDHSTTTIGEEPI--QDGP 1751
EE S N+ E+ + E+ ++ + I EE + ++
Sbjct: 4152 VEETESVNENILEETSINEVQKIESITEDIKEQLVPEEIKEEQLDSEEIKEEQLDSEEIK 4211
Query: 1750 AENKVIEGLEKVDLD-EHIGEHITEKDVAPDHSITSFE--EEPIKDFHEEDKVIEGTEIV 1580
E V E +++ LD E I E + + + + S E EE + +++ + EI
Sbjct: 4212 EEQLVPEEIKEEQLDSEEIKEEQLDSEEIKEEQLDSEEIKEEQLDSEEIKEEQLVPEEIK 4271
Query: 1579 GADKDIGDPIIGEEIVPDH-STTTIRGEPIQDDHEEEKVIEELKIDGANKDIGESSIKDV 1403
D + I E++VP+ + E I+++ + + I+E ++D +++I E +
Sbjct: 4272 EEQLD-SEEIKEEQLVPEEIKEEQLDSEEIKEEQLDSEEIKEEQLD--SEEIKEEQLDSE 4328
Query: 1402 VLDQSTTSIGETPVKD--------------AHEEHKVRVGANKDIGEPIIKENVVLDHPT 1265
+ + S+ E V++ +EE V + I E I++ +
Sbjct: 4329 EIKEQKGSVNEEVVEEEGSVTEEIKEQEESVNEEVLEEVEETESIKEEIVEGGIATQEII 4388
Query: 1264 KTIGEIKDKHEEDKVIEG---LDNDCVNXXXXXXXXXXXG--VREHSTKTTWEEPTKDGH 1100
+ + K+ EE+ VI+ +D V V E ST E K +
Sbjct: 4389 EEESDTKEVVEEE-VIDSEKLVDAGSVTGEVMPEEVSVTDEVVEEGSTTEEVLEEQKSVN 4447
Query: 1099 EDKVIEGLEIVDDVVPKPSTTITGEEAIR-NGQEENKVIEEL----EIVDAEEDIGEPII 935
E+ V +GL I D V + STT EE + +G K++EE EIV+ + + E I+
Sbjct: 4448 EEVVEDGLTIDDFVGLQGSTT---EEVVEEDGSAIEKILEEETATEEIVEKQVSVTEDIV 4504
Query: 934 EKDVVPGHTTTIGEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGES 755
EK+ ++ EE+I + ++I+G E ++VI E ++ E
Sbjct: 4505 EKE------GSVNEEIIEEASVAEEIIQGGSFTEEIVGQEESATEEVIDEEGLISNEIEE 4558
Query: 754 IKDAHXXXXXXXXXXIVGADKEIREPAIKEDVVPDLSTTTREEPIQDGHDINKVGEGLEI 575
++ V D E+ E ++ E++V EE + D ++ ++
Sbjct: 4559 EEEKSVTEEMIEEVEEVSVDDEVEEVSVAEEIV-------EEELVDDEILPEELSATEDV 4611
Query: 574 AGSDKDNGDPIIEEEVIPDH--------STTIIGEESTND---GHEEDKVVAVLDIVGVD 428
+ D I++EE + + S + ++S D GHE + V + V
Sbjct: 4612 IEEVRSVTDEIVQEESVCEEILEQEVSASEEYVDDKSVTDDFVGHERSVIQDVENTESVT 4671
Query: 427 KDIGE---PVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKV-----DLDKDIGEPI 272
++I E VIE+ V S T EE +Q+G + + IE LE V + DK + E
Sbjct: 4672 EEIAEVDKSVIEEAVEKQGSVT---EEKVQEGVSAIEEIEELESVTEEIAEEDKSVIEEA 4728
Query: 271 TEKDVAPDNFIAAFEEEAIKDVHEEDKV---IEETEIIGADKDIGDHIIGEEI------- 122
EK + I EE ++V E+ V + E E G D+ EE+
Sbjct: 4729 VEKQGSVTEEIVEEEELDTEEVLEDKSVTGDVVEQEGSGKDESEAKESFTEEVDELKSVK 4788
Query: 121 VPDHSTTTIRGEPIQDGHEEDKVTEELKID 32
D T I E ++ E +EL I+
Sbjct: 4789 EEDQETEYISREIEEESATEQHSEQELSIN 4818
Score = 124 bits (310), Expect = 3e-25
Identities = 290/1397 (20%), Positives = 582/1397 (41%), Gaps = 74/1397 (5%)
Frame = -1
Query: 4117 KDSEDKVKPILTKTQEPESERQMQKDQTNDTV---EATGDIIKGDKIDSCGEHALKKMSL 3947
+D ++++ P K ++ +SE ++ ++ + + + IK +++DS +K+ L
Sbjct: 4179 EDIKEQLVPEEIKEEQLDSEEIKEEQLDSEEIKEEQLVPEEIKEEQLDS---EEIKEEQL 4235
Query: 3946 DSARADNVGLVNSSALSTAPNDDDNIGEKLPAVPITSVSDDLNVQEGQTEGGNGADMDDM 3767
DS L +S + D + I E+ VP + L+ +E + E +
Sbjct: 4236 DSEEIKEEQL-DSEEIKEEQLDSEEIKEE-QLVPEEIKEEQLDSEEIKEE-----QLVPE 4288
Query: 3766 EQKNDVIFDDKQAPVVEHLQSGDIIRHHLVGNSKEVNGDQLTEGICASQSIEEDKAVTSS 3587
E K + + D + E L S +I L +S+E+ +QL S+ I+E K +
Sbjct: 4289 EIKEEQL--DSEEIKEEQLDSEEIKEEQL--DSEEIKEEQLD-----SEEIKEQKGSVNE 4339
Query: 3586 HEDQTEGTESGEDPDLKSGXXXXXXXXXXXEYYDKEKVVADDLYTHNISIEEVKQSGFQE 3407
+ EG+ + E + + KE++V + T I EE E
Sbjct: 4340 EVVEEEGSVTEEIKEQEESVNEEVLEEVEETESIKEEIVEGGIATQEIIEEESDTKEVVE 4399
Query: 3406 KELECKEQSSNSMGMVKD--PEKIGQMEDRDYENKEGVKMVTEETSLQKSEVEESWSPDN 3233
+E+ E+ ++ + + PE++ ++ E +++ E+ S+ + VE+ + D+
Sbjct: 4400 EEVIDSEKLVDAGSVTGEVMPEEVSVTDEVVEEGSTTEEVLEEQKSVNEEVVEDGLTIDD 4459
Query: 3232 -------THSHLLDE--TSLKPIDLQKERNDENATEPKIQDTKIMDIIGRVDIDDEEVPE 3080
T +++E ++++ I L++E E E ++ T+ DI+ + +EE+ E
Sbjct: 4460 FVGLQGSTTEEVVEEDGSAIEKI-LEEETATEEIVEKQVSVTE--DIVEKEGSVNEEIIE 4516
Query: 3079 QLE------------KDQPEMEQNDRKELPPEMKHEDLDFKGNGAQDVDGTPIEQINQGS 2936
+ ++ E++ +E+ E + + + V IE++ + S
Sbjct: 4517 EASVAEEIIQGGSFTEEIVGQEESATEEVIDEEGLISNEIEEEEEKSVTEEMIEEVEEVS 4576
Query: 2935 KMVQVTEVTHKD--IKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPEEEINEGL---D 2771
+V EV+ + ++EE D + L + IE + + EE + E + +
Sbjct: 4577 VDDEVEEVSVAEEIVEEELVDDEILPEELSATEDVIEEVRSVTDEIVQEESVCEEILEQE 4636
Query: 2770 IGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKDDGETVMEE 2591
+ +EE + V +D + H R+ IQ D + E EIA V K +V+EE
Sbjct: 4637 VSASEEYVDDKSVTDDFV-GHERSVIQ-----DVENTESVTE--EIAEVDK----SVIEE 4684
Query: 2590 DVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGE---SIIKENVVPDVSTTT-I 2423
V S T EE ++G + EI +++SV ++I E S+I+E V S T I
Sbjct: 4685 AVEKQGSVT---EEKVQEG--VSAIEEIEELESVTEEIAEEDKSVIEEAVEKQGSVTEEI 4739
Query: 2422 GEAQTKDVRE--EDKIIEGLNIDAD------EEVGDSITKDVVQDQSTTTIGEETIKCGH 2267
E + D E EDK + G ++ + E +S T++V + +S +ET
Sbjct: 4740 VEEEELDTEEVLEDKSVTGDVVEQEGSGKDESEAKESFTEEVDELKSVKEEDQETEYISR 4799
Query: 2266 EEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQP-----EIVGADREI 2102
E E E + ++ ++ ++I+E+ EIV +R+
Sbjct: 4800 EIEEESATEQHSEQELSINKEVVETESLTKDIEEEKSTTQEILEETQSVNEEIVEEERDT 4859
Query: 2101 REPVIE-----EDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVV 1937
E + E E+V+ + ++TT EE +++ ++++E ++ + + ++ E+V
Sbjct: 4860 DEVLKEKVSPSEEVIEEQASTT--EEFVEERSSTDEIVEVEDLFTEEVKEREGSVTEEIV 4917
Query: 1936 PNHSITTIGEESTNDGQEEDKVVAE----LDIVDVHKXXXXXXXXXXXXXDHSTTTIGEE 1769
S T GE +G + ++++ E +IV+ + ++ EE
Sbjct: 4918 EEGSDT--GEIVEEEGSDTEEILEEGSFNEEIVEEEGSITEEILQGSVTEEILQGSVTEE 4975
Query: 1768 PI-QDGPAENKVIEGLEKVDLDEHIGEHITEKDVAPDHSITSFEEEPIKDFHEEDKVIEG 1592
+ Q G +++E + ++E + E ++V S+T EE + D+V+EG
Sbjct: 4976 FVGQQGSVIEEIVE--TESAIEERVEEESATEEVDERESVTEVVEEEVSS---SDEVVEG 5030
Query: 1591 T--EIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEEL--KIDGANKDIG 1424
+ E++ + + + I+ E+ D + I++ E V EE+ + + +++I
Sbjct: 5031 SIEEVIENEGSVTEEILEHEVSADENFVGQAVSVIEEVEGTESVTEEVVEETESVSEEIV 5090
Query: 1423 ESSIKDVVLDQSTTSIGET-PVKDAHEEHKVRVGANKDIG----EPIIKENVVLDHPTKT 1259
E S + V+ Q+ + I E K+ ++ + D G E I E VV + T
Sbjct: 5091 EVSPTENVVQQTDSVIEEVVEQKEGSFNEEIDIRELGDDGVEEREKISTEEVVGQDKSAT 5150
Query: 1258 --IGEIKDKHEEDKV--IEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEE--PTKDGHE 1097
+ E+ +E++V EGL+ G+ E S EE T+D E
Sbjct: 5151 GDVEEVSSTEDEEEVSSTEGLEE----------VSSTEGLEEVSNTEDVEEVSSTEDVEE 5200
Query: 1096 DKVIEGLEIVDDVVPKPSTTITGEEAIRNGQEENKVIEELEIVDAEEDIGEPIIEKDVVP 917
V E + K + +IT E ++ +KV E E++ AE + E I+ + VP
Sbjct: 5201 GSVAENV--------KETKSITEEVSVEEDIITDKVSVEQEVM-AEASVEENILTE--VP 5249
Query: 916 GHTTTIGEEL-INDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAH 740
+ E+L + D + K++ E+V D + V +V+P + T +++
Sbjct: 5250 VEEEIMTEKLSVEDKALNEKIMSEEEIVIEDGN-----VHEVVPAEVSVTEEIPGVEET- 5303
Query: 739 XXXXXXXXXXIVGADKEIREPAIKEDVVPDLSTTTREEPIQDGHDINKVGEGLEIAGSDK 560
+ ++ + +VV D ++ E D I + +
Sbjct: 5304 -----------TNNESHVKGENVVNEVVVDDNSVNDEIQFDDDSSIEIYTVDSKDVFHKE 5352
Query: 559 DNGDPIIEEEVIPDHSTTIIGEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPNH 380
+N D EEV D + I +++ N + + + + V + E + E+ VP+H
Sbjct: 5353 ENYDSF-REEVRSDENIHIFRKKNENFVKKIENEKSSVGHVPTEYTSKENIAEE--VPSH 5409
Query: 379 STTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPITEKDVAPDNFIAAFEEEAIKDVHE 200
EN E ++V +++ E + E+ + +N I EEA D++
Sbjct: 5410 IMFK-----------ENVTEEVPKEVKYEENTVEEVFEEVTSKENII----EEAPGDINS 5454
Query: 199 EDKVIEETEIIGADKDI 149
E+ +IEE + ++I
Sbjct: 5455 EENIIEEVPEVVTSEEI 5471
Score = 121 bits (304), Expect = 1e-24
Identities = 292/1482 (19%), Positives = 591/1482 (39%), Gaps = 113/1482 (7%)
Frame = -1
Query: 4138 DELFKAFKDSEDKVKPILTKTQEPESERQMQKDQTNDTVE---ATGDI----IKGDKIDS 3980
DE SE + P ++P +E + + T++ VE T DI I +K+
Sbjct: 885 DETLTEQISSEHERVPEEIIEEKPFTEGEETESLTDEIVEEGVVTDDIPEEQIITEKVQE 944
Query: 3979 CGEHALKKMSLDSARADNVGLVNSSALSTAPNDDDNIGEKLPAVPITSVSDDLNVQEGQT 3800
E ++S + + V + S P ++D I EK+ ++ QE
Sbjct: 945 EEEFVTGELSEEDIINEKVQEEDESVTEELP-EEDIINEKVQE------EEESAYQEIVQ 997
Query: 3799 EGGNGADMDDMEQKNDVIFDDKQAPVVEHLQSGDIIRHHLVGNSKEVNGD-QLTEGICAS 3623
+G D++ E ND + D + + E G +I L + V + + E
Sbjct: 998 DGSVTKDVEYKELVNDDVRDKENFVIEEDPFKGQLINEGLPVEEEFVTKELPVKEESVFE 1057
Query: 3622 QSIEEDKAVTSSHEDQTEGTESGEDPDLKSGXXXXXXXXXXXEYYDKEKVVADDLYTHNI 3443
+ EED++VT + D E ++E V+ ++
Sbjct: 1058 ELTEEDQSVTKEIPVEEHSVFKEVDEIESVTDEIVEEEGSVNEEVEEEVSVSGEVDETEY 1117
Query: 3442 SIEEVKQSGFQEKELECKEQSSNSMGMVKDP----EKIGQMEDRDYENKEGVKMVTEETS 3275
EEV+++ +E+ KE+ S S +VK+ EKI + E E ++V EE S
Sbjct: 1118 VTEEVEETELVNEEV-LKEEGSASEKVVKEEGSASEKIVEEEGSVTEETASEEIVEEEGS 1176
Query: 3274 LQKSEVEESWSPDNTHSHLLDETSLKPIDLQKERN--DENATEPKIQDTKIMDIIGRVDI 3101
+ + E D + +E+S + I +++E + +E+A+E ++D ++ +I
Sbjct: 1177 VTEESSSEEIVEDE--GSVTEESSSEEI-VEEEGSVIEESASEVIVED----EVSASKEI 1229
Query: 3100 DDEEVPEQLEKDQPEMEQNDRKELPPEMKHEDLDFKGNGAQDVDGTPIEQINQGSKMVQV 2921
++E E + E +D ++ ++ E ++ VD +EQ
Sbjct: 1230 VEDEASVTEEVVEEEGAVSDEVQVTESVEDEIIN-----QGIVDEVIVEQ---------E 1275
Query: 2920 TEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKP--EEEINEGLDIGGAEEDT 2747
VT + +KE+ + E+A E+ E E KP EE +++G + EE
Sbjct: 1276 ASVTDEIVKEDESVIE--------EIAVEETVTEVVEETKPMDEEIVDQGSVVENVEEKK 1327
Query: 2746 --GEHIVENDVILDH--NRTTIQEEAIKDAHKEDKANEVLEIAGVGKDDGETVMEEDVVP 2579
E IV+ ++++ + T+ EE +K E E+ + E + ED+V
Sbjct: 1328 TMDEEIVDQGSVVENVEEKKTMDEEIGDQGSVAEKVEEE-ELVTEEVIEREGSINEDIVK 1386
Query: 2578 DPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIKENVVPDVSTTTIGEAQTKDV 2399
+ S T E+ E ++ KI+S+ +I E ++ E++ + AQ V
Sbjct: 1387 EASITEEVEQI------EPVTGKVEKIESITDEIKEQLVPEDIKEEQLDFEEIVAQRASV 1440
Query: 2398 REEDKIIEGLNIDADEEVGDSITKDVVQDQSTTTIGEETIKCGH-----EEERELXXXXX 2234
+E + + + +EE S++++V++++ +TT E+ +K EE+ +
Sbjct: 1441 NDEKVEVASITEEVEEEE-KSVSEEVLEEEGSTT--EKVVKGSSTEVVVEEQGSVTENLL 1497
Query: 2233 XXXXXXXXXXXXAVPATGEEPIKDGH--EKEKIIEQPEIVGADREIREPVIEEDVVPDLS 2060
E+ +KD + EKE + + + I E +E+++ ++S
Sbjct: 1498 EEESASQGIVEKEEFVDEEDSVKDQNVFEKEGSVTEQLVEEEKGLINEDNEKEELITEMS 1557
Query: 2059 TT--TTREEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVVPNHSITTIGEESTNDGQ 1886
+ EE + ++I+ +A+ + ++ +++ S+T E+ Q
Sbjct: 1558 EEIKSVNEEIEETDLSTEEIIKQQGLATYEFVEEEKSLTDKLLEEESVTKEVGETELSTQ 1617
Query: 1885 E--EDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAENKVIEGLEKVD 1712
E ++KV ++++ K ++ EE +++G A +V+E E
Sbjct: 1618 EVVDEKVSVTEEVIEEEK------------------SVSEEVLEEGSATEEVVE--EGSC 1657
Query: 1711 LDEHIGEHITEKDVAPDHSITSFEEEPIKDFHEEDKVIEGTEIVGADKDIGDPIIGEEIV 1532
+ + E + V + S T E D TEIV + + E +V
Sbjct: 1658 TEVVVEEGSCTEVVVEEGSCTEIVVEKGSD----------TEIV-----VEEGSATEIVV 1702
Query: 1531 PDHSTTTIRGEPIQDDHEEEKVIEELKIDGANKDIGESSIKDVV---LDQSTTSIGETPV 1361
+ S T + +++ E+V+EE + + S+ ++VV L + +
Sbjct: 1703 EEGSATEV---VVEEGSATEEVVEEGSVSEEMLEEEGSATEEVVEEGLSSDNVQKSKGVI 1759
Query: 1360 KDAHEEHKVRVGANKDIGE--PIIKENVVLDHPTKTIG-----EIKDKHEEDKVIEG--L 1208
++ E + V+ ++ + E P+ K + V D K G ++D + ED + E L
Sbjct: 1760 ENVGEIYSVKTAKDESMNEKIPLEKSSFVDDESFKGQGPTDNVSVEDVNSEDIINEHTPL 1819
Query: 1207 DNDCVNXXXXXXXXXXXGVREHSTKTTW--------EEPTKDG-HEDKVIEGL-----EI 1070
+ + + T+T + EE K E+K+ E + +
Sbjct: 1820 EETKIEELPTEYITTADIHTKGETETKYNLIYEKINEEVEKAKFQEEKITENIPVERESV 1879
Query: 1069 VDDVVPKPSTT--ITGEEAIRNGQEENKVIEEL--------------------EIVDAEE 956
+D+V +PS + +E+ N EE K+ E E+++ +E
Sbjct: 1880 TEDIVQEPSLAQEVEQKESDTNEIEETKLANEKIIPEVSVTENVVEKEGLDTEEVLEEDE 1939
Query: 955 DIGEPIIEKDVVPGHTTTIGEELINDVHDDNKVIEGFEMVGSDKDTGEPVV-------DD 797
I E I+E++V EE ++ + + E+V ++ + E +V ++
Sbjct: 1940 SITEEIVEEEVSSSEEIVEEEESSSEEIVEEEESSSEEIVEEEESSSEEIVEEEESSSEE 1999
Query: 796 VIPEHSTTT-------SVGESIKDAHXXXXXXXXXXIVGADKEIRE-PAIKEDVVPDLST 641
++ E +++ S E + + V +E+++ ++ E+V+ +
Sbjct: 2000 IVEEEESSSEEIIEEVSSTEEVLEEEGSVTEEIVEEEVSTTEEVKDIGSVSEEVLEEEGF 2059
Query: 640 TTREEPIQDGHDINKVGEG-------LEIAGSDKDNGDPIIEEEVIPDHSTTIIGEESTN 482
T E Q G I ++ E LE GS N + I++EE P + E ST
Sbjct: 2060 GTEEFVGQQGSVIEEIVETESSTEKVLEDVGS---NVEEIVQEEG-PVAQEIVHEEVSTT 2115
Query: 481 DGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEG---L 311
+ H+E +IV + E +I + V + EE +++G +V+E +
Sbjct: 2116 EKHDEVDRSTTEEIVEKVGSVSEEIIVEEV-------SASEEIVEEGSVTEEVVEEEKLI 2168
Query: 310 EKVDLDKDIGEPITEKDVAPDNFIAAFEEEAIKDVHEEDKVIEETEIIGADKDIGDHIIG 131
+V + + E I +K+V+ + E +++ E++ ++E EI+G + + + I+
Sbjct: 2169 NEVGETESVTEEIVQKEVSDAEEVLGQEGSMNEEILEKESIVE--EIVGPEGSVTEEIVD 2226
Query: 130 ---------EEIVPDHSTTTIRGEPIQDGHEEDKVTEELKID 32
EE + G ++ EE+ +TE I+
Sbjct: 2227 HGSFAEEVKEEELVTEEAVQYEGSVTEEIKEEESITENEAIE 2268
Score = 117 bits (293), Expect = 3e-23
Identities = 308/1540 (20%), Positives = 599/1540 (38%), Gaps = 183/1540 (11%)
Frame = -1
Query: 4111 SEDKVKPILTKTQEPESERQMQKDQTNDT-----VEATGDIIKGDKIDSCGEHALKKMSL 3947
+E+K+K + +E E +++D ++ V + + + +D G +
Sbjct: 3100 TEEKLKEEASAIEEFVEEESIREDVLEESLVTENVVGQQESVTEEIVDGEGSFTEDIVEE 3159
Query: 3946 DSARADNVGLVNSSALSTAPNDDDNIGEKLPAVPITSVSDDLNVQEGQTEGGNGADMDDM 3767
+ + + + + S D++ + E++ V D+ + E E G+ +++
Sbjct: 3160 EESVTEEIVVDEESVTKEIVEDEELVTEEI-------VEDEGSFTEEIVED-EGSFTEEV 3211
Query: 3766 EQKNDVIFDDKQAPVVEHLQSGDIIRHHLVGNSKEVNGDQLTEGICASQSIEEDKAVTSS 3587
++ +I + + V + G +I+ + ++ LTE I +EE+K+VT
Sbjct: 3212 IEERSLIEEVEDTETVAEKEEGSVIK-------EIIDEKSLTEKI-----VEEEKSVTEE 3259
Query: 3586 HEDQTEGTESGEDPDLKSGXXXXXXXXXXXEYYDKEKVVADDLYTHNISIEEVKQSGFQE 3407
E++ E E+ L + E +V D L T I + + F E
Sbjct: 3260 VEEKESVKEEVEEQRLVVEEEGSATEGIVEDRLATEGIVDDILVTEEIVEDGLATDEFVE 3319
Query: 3406 KELECKEQSSNSMGMVKDPEKIGQMEDRDYENKEGVKMVTEETSLQK--------SEVEE 3251
++ E+ + G V + E + + + E EGV ++ E+ +++ S EE
Sbjct: 3320 QQGSIIEEVLDDEGSVTE-EIVEEEGSPNEEIVEGVSVIEEDDNIEPVSEEIVEGSVTEE 3378
Query: 3250 SWSPDNTHSHLLDETSLKPIDLQKERN-------------------DENATEPKIQDTKI 3128
+ +LDE S+ L+KE + + + +E I++
Sbjct: 3379 MIKEGLENEVILDEDSITEEALEKEGSVSEEIVEEMGSLTEEIVDEERSTSEDMIEEGSA 3438
Query: 3127 MDIIGRVDIDDEEVPEQLEKDQPEMEQN--DRKELPPEMKHEDLDFKGNGAQDVDGTPIE 2954
+ I + + EEV E++ +E++ D KE+ E++ + + ++ +G+ E
Sbjct: 3439 SEEIIQEESQVEEVVEEVSVIDEIVEEDELDTKEVVEEIEFNTEEVVEH--KEEEGSVAE 3496
Query: 2953 QINQGSKMVQVTE--------VTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKP 2798
+I Q K V E +T + ++++ D +++ E + IE ++E+ +K
Sbjct: 3497 EIVQEEKEGSVNEEIIEEVGSITEEMVEQDVSDNEEI----VEERSVIEEAEENVWIEKE 3552
Query: 2797 EEEINEGLDI-------GGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVL 2639
EE EGLD E E + N+ IL + + + E+ E
Sbjct: 3553 VEE--EGLDNEEVIDEEDSVSEQAEEEVYINEEILKESSDVEDVKVENELMNEEVNEETQ 3610
Query: 2638 EIAGVGKDDGETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKDIGESIIK 2459
+A ++D E ++ VV + T ++ EE D K E+ +I+S+ ++I E +
Sbjct: 3611 SVAENNEEDKE--LDNYVVEE--TESVTEEVVVDEVPNSK--EVQEIESIIEEIVEDGLT 3664
Query: 2458 ENVVPDVSTTTIGEAQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTT----TIG 2291
+ + + I E + + ++I+E +I + E +S+T+D++ ++S T G
Sbjct: 3665 TDDLVGQQGSVIEEVVEEVGSDSEEIVEEASITEEVEKKESVTEDILVEESVTGDILVEG 3724
Query: 2290 EETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQPEIVGAD 2111
T + EE+ PAT E I++ E V +
Sbjct: 3725 SVTEEVVGEEKLVSEEIVTEEGSVAQEIVEEDAPATEE------------IDEIESVTEE 3772
Query: 2110 REIREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKD--NGDPTIEGEVV 1937
E ++E++V + + T EE IQ + +V+E E S N++ + + E+V
Sbjct: 3773 VVEEEGPVDEEIVQEEGSVT--EEIIQGESKVEEVVE--EQGSENEEIFVEEVSASQEIV 3828
Query: 1936 PNHSITTIGEESTNDGQE--EDKVVAELDIVDVHKXXXXXXXXXXXXXDH---STTTIGE 1772
N S T E + QE +D V E I++ K H + E
Sbjct: 3829 QNESGTEEILEKVSASQEIVQDGSVTE-QIIEEQKPVTEEVVNEEESITHEIIQEESHVE 3887
Query: 1771 EPIQDGPAENKVIEG---------------LEKVDLDEHIGEHITEKDVAPDHSITSFEE 1637
+ +Q G +V+E E + + ++ E I E++ + I EE
Sbjct: 3888 KVVQQGSVAEEVVENPVSVTEEIVEKEGSVTEDIGQEGYVAEEIVEEEEFDNEEILE-EE 3946
Query: 1636 EPIKDFHEED--------KVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDH 1481
++F EE + I +EIV + + + ++ EE G ++
Sbjct: 3947 SVAEEFVEEGFDNEEIFVEQISDSEIVKEENSVNEEVLEEEGSYTEEILEEEGSYTEEIL 4006
Query: 1480 EE-----EKVIEE--------LKIDGA-NKDI--GESSIKDVVLDQSTTSIGETPVKDAH 1349
EE E+++EE L+ +G+ N++I E S + +L++ S E +++
Sbjct: 4007 EEEGSFTEEILEEEGSYNEEILEEEGSYNEEILEEEGSYNEEILEEE-GSYNEEILEEEG 4065
Query: 1348 EEHKVRVGANKDIGEPIIKENVVLDHPTKTIGEIKDKHEEDKVIEGLDND-------CVN 1190
VG D E II+E D+ +G+ D E+ + EG D +
Sbjct: 4066 SATDYFVGQGSD-NEEIIEEGSATDY---FVGQGSD--NEEIIEEGSATDYFVGQGSIIE 4119
Query: 1189 XXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVIEGLEIVDDVVPKPST--TITGEEAI 1016
V E+ T E T+ E V+E E V++ + + ++ + E+I
Sbjct: 4120 EVLEEEGLDTEKVFENEGSATEFEETESFTE--VVEETESVNENILEETSINEVQKIESI 4177
Query: 1015 RNGQEENKVIEEL-------EIVDAEEDIGEPIIEKDVVPGH-------TTTIGEELIND 878
+E V EE+ E + E+ E I E+ +VP + I EE ++
Sbjct: 4178 TEDIKEQLVPEEIKEEQLDSEEIKEEQLDSEEIKEEQLVPEEIKEEQLDSEEIKEEQLDS 4237
Query: 877 VHDDNKVIEGFEMVGSDKDTGEPVVDDVIPEH-----------STTTSVGESIKDAHXXX 731
+ ++ E+ D+ E + ++PE V E IK+
Sbjct: 4238 EEIKEEQLDSEEIKEEQLDSEEIKEEQLVPEEIKEEQLDSEEIKEEQLVPEEIKEEQLDS 4297
Query: 730 XXXXXXXIVGAD--------KEIREPAIKEDVVPDLSTTTREEPIQD----GHDINKVGE 587
+ + +EI+E + + + + + EE +++ +I + E
Sbjct: 4298 EEIKEEQLDSEEIKEEQLDSEEIKEEQLDSEEIKEQKGSVNEEVVEEEGSVTEEIKEQEE 4357
Query: 586 GLEIAGSDKDNGDPIIEEEVIPDHSTT--IIGEESTNDGHEEDKVVAVLDIVGVDKDIGE 413
+ ++ I+EE++ T II EES E++V+ +V GE
Sbjct: 4358 SVNEEVLEEVEETESIKEEIVEGGIATQEIIEEESDTKEVVEEEVIDSEKLVDAGSVTGE 4417
Query: 412 PV-----IEDNVVPNHSTT--------TTGEEPIQD-----------GQAENKVIE---- 317
+ + D VV STT + EE ++D G +V+E
Sbjct: 4418 VMPEEVSVTDEVVEEGSTTEEVLEEQKSVNEEVVEDGLTIDDFVGLQGSTTEEVVEEDGS 4477
Query: 316 GLEKVDLDKDIGEPITEKDVAPDNFIAAFEEEAIKDVHEEDKVIEE--------TEIIGA 161
+EK+ ++ E I EK V+ I E +++ EE V EE EI+G
Sbjct: 4478 AIEKILEEETATEEIVEKQVSVTEDIVEKEGSVNEEIIEEASVAEEIIQGGSFTEEIVGQ 4537
Query: 160 DKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEEL 41
++ + +I EE + + + EE VTEE+
Sbjct: 4538 EESATEEVIDEEGLISNEI---------EEEEEKSVTEEM 4568
Score = 99.0 bits (245), Expect = 1e-17
Identities = 204/974 (20%), Positives = 392/974 (40%), Gaps = 31/974 (3%)
Frame = -1
Query: 2836 IESSKEDNEAKK--PEEEINEGLDIGGAEE-----DTGEHIVENDVILDHNRTTIQEEAI 2678
+E ++++NE +K E + E + G EE + + +EN++I+DH I+EE
Sbjct: 605 MEETEKENEIEKIMDENKETEQTEEGNTEEFVQEKELNQETLENEIIVDH----IKEE-- 658
Query: 2677 KDAHKEDKANEVLEIAGVGKDDGETVMEEDVVPD-PSTTTIGEEPTKDGHEEDKVIEISK 2501
ED N + E+V+EE + + P IG+ + EE + EI
Sbjct: 659 -----EDTRN---------VKEQESVLEESPIEELPVENNIGK--INEEVEEFILNEIPL 702
Query: 2500 IDSVDKDIGESIIKENVVPDVSTTTIGEAQTKDVREEDKIIEGLNIDADEEVGD-SITKD 2324
+ V K++ + I+E VV ++ ++ V EED +G I+ ++ V + S++++
Sbjct: 703 EEQVPKELPQEEIEEIVVEELPIDEHLSSEETTVTEED-TFKGQLINEEKPVEEKSVSEE 761
Query: 2323 VVQDQSTTTIGEETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEK 2144
+ ++ + + E P+++ E+
Sbjct: 762 IPVEEKS--------------------------------------VSEEIPVEEKSVSEE 783
Query: 2143 IIEQPEIVGADREIREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNG 1964
I + + V + + E + E+ +P + E P+++ + ++ E S G
Sbjct: 784 IPVEEKSVSEEIPVEEKNVSEE-IPVEEKNVSEEIPVEEKNVSEEIPVEEENVSEEIPEG 842
Query: 1963 DPTIEGEVVPNHSITTIGEESTNDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTT 1784
IE V ++T EE T D + DK+ E++ V+ +H
Sbjct: 843 GIAIEDVPVDEETVT---EEITVDEKIYDKLPNEIETVNEEMPVEDETLTEQISSEHE-- 897
Query: 1783 TIGEEPIQDGPAENKVIEGLEKVDL-DEHIGEHITEKDVAPDHSIT----SFEEEPIKDF 1619
+ EE I++ P EG E L DE + E + D+ + IT EE +
Sbjct: 898 RVPEEIIEEKP----FTEGEETESLTDEIVEEGVVTDDIPEEQIITEKVQEEEEFVTGEL 953
Query: 1618 HEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGA 1439
EED + E ++ D+ + + + E+I+ E +Q+ EEE +E+ DG+
Sbjct: 954 SEEDIINE--KVQEEDESVTEELPEEDII---------NEKVQE--EEESAYQEIVQDGS 1000
Query: 1438 -NKDIG-ESSIKDVVLDQSTTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDHPT 1265
KD+ + + D V D+ I E P K G + G P+ +E V + P
Sbjct: 1001 VTKDVEYKELVNDDVRDKENFVIEEDPFK----------GQLINEGLPVEEEFVTKELPV 1050
Query: 1264 KTIGEIKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVI 1085
K ++ EED+ + V EHS +E + D+++
Sbjct: 1051 KEESVFEELTEEDQSV----------------TKEIPVEEHSVFKEVDE--IESVTDEIV 1092
Query: 1084 EGLEIVDDVVPKPSTTITGE----EAIRNGQEENKVIEELEIVDAEEDIGEPIIEKDVVP 917
E V++ V + +++GE E + EE +++ E E++ E E +++++
Sbjct: 1093 EEEGSVNEEV-EEEVSVSGEVDETEYVTEEVEETELVNE-EVLKEEGSASEKVVKEEGSA 1150
Query: 916 GHTTTIGEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDD---VIPEHSTTTSVGESIKD 746
E + + +++E V +++ + E +V+D V E S+ V E
Sbjct: 1151 SEKIVEEEGSVTEETASEEIVEEEGSV-TEESSSEEIVEDEGSVTEESSSEEIVEEEGSV 1209
Query: 745 AHXXXXXXXXXXIVGADKEI--REPAIKEDVVPDLSTTTREEPIQDGHDINKVGEGLEIA 572
V A KEI E ++ E+VV + + E + + + + +G
Sbjct: 1210 IEESASEVIVEDEVSASKEIVEDEASVTEEVVEEEGAVSDEVQVTESVEDEIINQG---- 1265
Query: 571 GSDKDNGDPIIEEEVIPDHSTTIIGEESTNDGHEEDKVV---AVLDIVGVDKDIGEPVIE 401
I +EVI + ++ E D +++ V ++V K + E +++
Sbjct: 1266 ----------IVDEVIVEQEASVTDEIVKEDESVIEEIAVEETVTEVVEETKPMDEEIVD 1315
Query: 400 D-NVVPNHSTTTTGEEPIQDGQAENKVIEGL-EKVDLDKDIGEPITEKDVAPDNFIAAFE 227
+VV N T +E I D + V+E + EK +D++IG+ +
Sbjct: 1316 QGSVVENVEEKKTMDEEIVD---QGSVVENVEEKKTMDEEIGD----------------Q 1356
Query: 226 EEAIKDVHEEDKVIEETEIIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEE-DKVT 50
+ V EE+ V E E+I + I + I+ E + + EP+ E+ + +T
Sbjct: 1357 GSVAEKVEEEELVTE--EVIEREGSINEDIVKEASITEEVEQI---EPVTGKVEKIESIT 1411
Query: 49 EELKIDGAKKDIGE 8
+E+K +DI E
Sbjct: 1412 DEIKEQLVPEDIKE 1425
Score = 63.9 bits (154), Expect = 4e-07
Identities = 139/650 (21%), Positives = 250/650 (38%), Gaps = 86/650 (13%)
Frame = -1
Query: 1735 IEGLEKVDLDEHIGEHITEKDVAPDHSITSFEE-------EPIKDFHEEDKVIE--GTEI 1583
+ G K +E + E +E+ ++I EE E I D ++E + E TE
Sbjct: 575 VHGTGKTKKEEKMKELESEEFPKEKYNIEDMEETEKENEIEKIMDENKETEQTEEGNTEE 634
Query: 1582 VGADKDIGDPIIGEEIVPDH--STTTIRGEPIQDDHEEEKVIEELKIDG----ANKDIGE 1421
+K++ + EI+ DH R Q+ EE IEEL ++ N+++ E
Sbjct: 635 FVQEKELNQETLENEIIVDHIKEEEDTRNVKEQESVLEESPIEELPVENNIGKINEEVEE 694
Query: 1420 SSIKDVVLDQSTTS-----------IGETPVKD--AHEEHKVR---------VGANKDIG 1307
+ ++ L++ + E P+ + + EE V + K +
Sbjct: 695 FILNEIPLEEQVPKELPQEEIEEIVVEELPIDEHLSSEETTVTEEDTFKGQLINEEKPVE 754
Query: 1306 EPIIKENVVLDHPTKTIGE---IKDKH-------EEDKVIEGLDNDCVNXXXXXXXXXXX 1157
E + E + ++ K++ E +++K EE V E + + N
Sbjct: 755 EKSVSEEIPVEE--KSVSEEIPVEEKSVSEEIPVEEKSVSEEIPVEEKNVSEEIPVEEKN 812
Query: 1156 GVRE---HSTKTTWEEPTKDGH-EDKVIEGLEIVDDVVPKPSTTITGEEAIRNGQEENKV 989
E + E P ++ + +++ EG ++D VP T+T EE + + +K+
Sbjct: 813 VSEEIPVEEKNVSEEIPVEEENVSEEIPEGGIAIED-VPVDEETVT-EEITVDEKIYDKL 870
Query: 988 IEELEIVDAEEDIGEPIIEKDVVPGHTTTIGEELINDVHDDNKVIEGFEMVG-SDKDTGE 812
E+E V+ E + + + + + H E + ++ ++ EG E +D+ E
Sbjct: 871 PNEIETVNEEMPVEDETLTEQISSEH-----ERVPEEIIEEKPFTEGEETESLTDEIVEE 925
Query: 811 PVVDDVIPEHSTTT---SVGESIKDAHXXXXXXXXXXIVGADKEIREPAIKEDV----VP 653
VV D IPE T E + D+ + E +ED+ V
Sbjct: 926 GVVTDDIPEEQIITEKVQEEEEFVTGELSEEDIINEKVQEEDESVTEELPEEDIINEKVQ 985
Query: 652 DLSTTTREEPIQDGHDINKVGEGLEIAGS---DKDN---------------GDPIIEEEV 527
+ + +E +QDG + K E E+ DK+N G P+ EE V
Sbjct: 986 EEEESAYQEIVQDG-SVTKDVEYKELVNDDVRDKENFVIEEDPFKGQLINEGLPVEEEFV 1044
Query: 526 ---IPDHSTTIIGEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEE 356
+P ++ E + D ++ V + D E V ++ V S EE
Sbjct: 1045 TKELPVKEESVFEELTEEDQSVTKEIPVEEHSVFKEVDEIESVTDEIVEEEGSVNEEVEE 1104
Query: 355 PIQ-DGQAENK--VIEGLEKVDLDKDIGEPITEKDVAPDNFIAAFEEEAIKDVHEEDKVI 185
+ G+ + V E +E+ +L + E + E+ A + + + K V EE V
Sbjct: 1105 EVSVSGEVDETEYVTEEVEETELVNE--EVLKEEGSASEKVVKEEGSASEKIVEEEGSVT 1162
Query: 184 EET---EIIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEE 44
EET EI+ + + + EEIV D + T + EE V EE
Sbjct: 1163 EETASEEIVEEEGSVTEESSSEEIVEDEGSVTEESSSEEIVEEEGSVIEE 1212
>gb|AAF15293.3| erythrocyte membrane-associated giant protein antigen 332 [Plasmodium
falciparum]
Length = 5458
Score = 134 bits (336), Expect = 3e-28
Identities = 296/1472 (20%), Positives = 603/1472 (40%), Gaps = 161/1472 (10%)
Frame = -1
Query: 3958 KMSLDSARADNVGLVNSSALSTAPNDDDNIGEKLPAVPITSVSDDLNVQEGQTEGGNGAD 3779
K+ + D V S + +++++ E++ ++ S+++ E T+ G +
Sbjct: 1799 KIIEEEVSVDEVVEEEGSVIEEIVEEEESVPEEILEEELSG-SEEVLEDEWVTDAFMGQE 1857
Query: 3778 MDDMEQKNDVIFDDKQAPVVEHLQSGDIIRHHLVGNS----KEVNGDQLTEGICASQSIE 3611
+E+ +++ D + + E + +V +EV G EG + IE
Sbjct: 1858 GSVIEEIEEIV--DGEGSITEEIVEDGSANEKIVEEEPSRVEEVLGK---EGFVIEEIIE 1912
Query: 3610 EDKAVTSSHEDQTEGTESGEDPDLKSGXXXXXXXXXXXEYYDKEKVVADDLYTHNISIEE 3431
E + + +T +S E ++ + +KE+ V +++ S E
Sbjct: 1913 EGSVIEQVEDTKTVSEKSEESSAIEEVKEVKEEESISEKIVEKEESVTEEIVRQEESTTE 1972
Query: 3430 --VKQSGFQEKELECK--------EQSSNSMGMVKDPEKIGQMEDRDYENKEGV------ 3299
VK E +E EQ ++ + +D E+ D + V
Sbjct: 1973 KIVKDVSPTEDFVEQTDSVTEKVIEQEGSNTEVAEDVEEKESASDEHEQEDVSVNAQVTC 2032
Query: 3298 --KMVTEETSLQKSEVEESWSPDNTHSHLLDETSLKPIDLQKERN-------DENATEPK 3146
K VT+E + S EE + + + +DET ++ +E D + TE
Sbjct: 2033 EKKSVTKEIVDEVSRTEEIVEENGSVTEGVDETGSVTEEIIEEATVTEEVVEDGSVTEEV 2092
Query: 3145 IQD-TKIMDIIGRVDIDDE------EVPEQLEKDQPEMEQNDRKELP-------PEMKHE 3008
++D + I +++ + +E V E++ +++ + + +E+ E E
Sbjct: 2093 VEDGSVIQEVVEDGSVTEEIVQENGSVTEEIVEEEGSVNEEVEEEVSVSGEVDETEYVTE 2152
Query: 3007 DLDFKGNGAQDV---DGTPIEQI--NQGSKMVQVTE----VTHKDIKEEGCDFKDLGTIS 2855
+++ +G+ +++ +G+ +E+I +GS + ++ E V + ++EEG ++ I
Sbjct: 2153 EVEEEGSVVEEIVEEEGSVVEEIVEEEGSVVEEIVEEEGSVVEEIVEEEGSVVEE---IV 2209
Query: 2854 TGELAGIESSKEDNEAKKPEEEINEGLDIGGAEEDTG---EHIVENDVILDHNRTTIQEE 2684
E + +E E+ + E EG + E+ G E IVE + + +
Sbjct: 2210 EEEGSVVEEIVEEEGSVVEEIVEEEGSVVEEIVEEEGSVVEEIVEEEGSVVEEIVEEEGS 2269
Query: 2683 AIKDAHKEDKA--NEVLEIAGVGKDDGETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIE 2510
+++ +E+ + E++E G + E V EE V + G + EE V+E
Sbjct: 2270 VVEEIVEEEGSVVEEIVEEEGSVVE--EIVEEEGSVVEEIVEEEGSVVEEIVEEEGSVVE 2327
Query: 2509 --ISKIDSVDKDIGES-IIKENVVPDVSTTTIGEAQTKDVREEDKIIEGLNIDADEEVGD 2339
+ + SV + + E+ ++ + +V T E Q V D+IIE ++ E +
Sbjct: 2328 EIVEEEGSVSEVVDETELVNDEIVEQAPFTEEVEEQ---VSVNDEIIEDASVAEAVEESE 2384
Query: 2338 SITKDVVQDQSTTTIGEETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDG 2159
SIT+ V Q++ T E+ EE A EE ++DG
Sbjct: 2385 SITESVSQEEET----EKGFVIEKVEE---------------------TGAVTEEIVQDG 2419
Query: 2158 HEKEKIIEQPEIVGADREIREPVIEEDVVPDLSTT-------TTREEPIQDGHDINKVIE 2000
E+I+E+ E V + +E EE + + T +T EE +++ + K +E
Sbjct: 2420 LITEEILEESESVNGEIINKESDAEEILETEFLTEEVVGQAGSTSEEIVEEEGSVTKEVE 2479
Query: 1999 GLE-IASSNKDNGDPTIEGEVVPNHSIT--------TIGEESTNDGQEEDKVVA-ELDIV 1850
E + D G ++ E+V S+T +I +E + ++++ E ++
Sbjct: 2480 EKESVTEELVDEG--SVTEELVDEGSVTEEVVEQGGSIAQEIVEEESATEEIIRDETNVE 2537
Query: 1849 DVHKXXXXXXXXXXXXXDHSTTTIG------EEPIQD--GPAENKVIE---GLEKVDLDE 1703
+V + + +G EE +++ E K+ E +E+ +E
Sbjct: 2538 EVLEKEGSATEEIVQDGSGTNDFVGKQGSVIEEVVEEEISTTEEKLKEEASAIEEFVEEE 2597
Query: 1702 HIGEH------ITEKDVAPDHSIT--------SFEEEPIKDFHEEDKVIEGTEIVGADKD 1565
I E +TE V S+T SF E+ ++ EE+ V E EIV ++
Sbjct: 2598 SIREDVLEESLVTENVVGQQESVTEEIVDGEGSFTEDIVE---EEESVTE--EIVVDEES 2652
Query: 1564 I------GDPIIGEEIVPDHSTTTIRGEPIQDDH--------EEEKVIEELKIDG--ANK 1433
+ + ++ EEIV D + T E I +D EE +IEE++ A K
Sbjct: 2653 VTKEIVEDEELVTEEIVEDEGSFT---EEIVEDEGSFTEEVIEERSLIEEVEDTETVAEK 2709
Query: 1432 DIGESSIKDVVLDQSTTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDHPTKTIG 1253
+ G S IK+++ ++S T K EE + + +++ E + VV + + T G
Sbjct: 2710 EEG-SVIKEIIDEKSLTEKIVEEEKSVTEEVEEKESVKEEVEE---QRLVVEEEGSATEG 2765
Query: 1252 EIKDKHEEDKVIEGL--------DNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGH- 1100
++D+ + +++ + D + V + T E ++G
Sbjct: 2766 IVEDRLATEGIVDDILVTEEIVEDGLATDEFVEQQGSIIEEVLDDEGSVTEEIVEEEGSP 2825
Query: 1099 EDKVIEGLEIV---DDVVPKPSTTITG---EEAIRNGQEENKVIEE----LEIVDAEEDI 950
++++EG+ ++ D++ P + G EE I+ G E +++E E ++ E +
Sbjct: 2826 NEEIVEGVSVIEEDDNIEPVSEEIVEGSVTEEMIKEGLENEVILDEDSITEEALEKEGSV 2885
Query: 949 GEPIIEK-----DVVPGHTTTIGEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDVIPE 785
E I+E+ + + + E++I + ++I+ V + V+D+++ E
Sbjct: 2886 SEEIVEEMGSLTEEIVDEERSTSEDMIEEGSASEEIIQEESQV-EEVVEEVSVIDEIVEE 2944
Query: 784 HS-TTTSVGESIK-DAHXXXXXXXXXXIVGAD--KEIREPAIKEDVVPDLSTTTREEPIQ 617
T V E I+ + V + +E +E ++ E+++ ++ + T E Q
Sbjct: 2945 DELDTKEVVEEIEFNTEEVVEHKEEEGSVAEEIVQEEKEGSVNEEIIEEVGSITEEMVEQ 3004
Query: 616 DGHDINKVGEGLEIAGSDKDNG--DPIIEEEVIPDHSTTIIGEESTNDGHEEDKVVAVLD 443
D D ++ E + ++N + +EEE + + +I EE + E++V +
Sbjct: 3005 DVSDNEEIVEERSVIEEAEENVWIEKEVEEEGLDNEE--VIDEEDSVSEQAEEEVYINEE 3062
Query: 442 IVGVDKDIGEPVIED---NVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPI 272
I+ D+ + +E+ N N T + E +D + +N V+E E V + + E
Sbjct: 3063 ILKESSDVEDVKVENELMNEEVNEETQSVAENNEEDKELDNYVVEETESVTEEVVVDEVP 3122
Query: 271 TEKDVAPDNFIAAFEEEAIKD-------VHEEDKVIEE-TEIIGADKD--IGDHIIGEEI 122
K+V I + EE ++D V ++ VIEE E +G+D + + + I EE+
Sbjct: 3123 NSKEVQE---IESIIEEIVEDGLTTDDLVGQQGSVIEEVVEEVGSDSEGIVEEASITEEV 3179
Query: 121 VPDHSTTTIRGEPIQDGHEEDKVTEELKIDGA 26
S T +D E+ VT ++ ++G+
Sbjct: 3180 EKKESVT-------EDILVEESVTGDILVEGS 3204
Score = 132 bits (332), Expect = 8e-28
Identities = 297/1469 (20%), Positives = 592/1469 (40%), Gaps = 112/1469 (7%)
Frame = -1
Query: 4111 SEDKVKPILTKTQEPESERQMQKDQTNDTVEATGDIIKGDKIDSCGEHALKKMSLDSARA 3932
+++KV+ + + T+E E E +K + + +E G S E +++ S
Sbjct: 866 NDEKVE-VASITEEVEEE---EKSVSEEVLEEEG---------STTEKVVEEGSSTEVVV 912
Query: 3931 DNVGLVNSSALSTAPNDDDNIGEKLPAVPITSVSDDLNVQEGQTEGGNGADMDDMEQKND 3752
+ G V+ L + + + E+ +V + ++ + +G E D +D + +
Sbjct: 913 EEQGSVSEEVLEEEGSTTEEVVEEQGSVTENLLEEE-SASQGIVEKEEFVDEEDSVKDQN 971
Query: 3751 VIFDDKQAPVVEHL---QSGDI------------IRHHLVGNSKEVNGDQLT-------E 3638
V +K+ V E L + G I + + ++E+ L+ +
Sbjct: 972 VF--EKEGSVTEQLVEEEKGLINEDNEKEELITEMSEEIKSVNEEIEETDLSTEEIIKQQ 1029
Query: 3637 GICASQSIEEDKAVTSSHEDQTEGTESGEDPDLKSGXXXXXXXXXXXEYYDKEKVVADDL 3458
G+ + +EE+K++T ++ T+ + +L + E ++EK V++++
Sbjct: 1030 GLATYEFVEEEKSLTDKLLEEESVTKEVGETELSTQEVVDEKVSVTEEVIEEEKSVSEEV 1089
Query: 3457 YTHNISIEEVKQSGF---------QEKELECKEQSSNSMGMVKDPEKIGQMEDRDYENKE 3305
+ EEV + G + E+ +E S+ + + E+ E E
Sbjct: 1090 LEEGSATEEVVEEGSCTEIVVEKGSDTEIVVEEGSATEIVV----EEGSATEVVVEEGSV 1145
Query: 3304 GVKMVTEETSLQKSEVEESWSPDNTHSH---------------LLDETSLKPIDLQKER- 3173
+M+ EE S + VEE S DN DE+ + I L+K
Sbjct: 1146 SEEMLEEEGSATEEVVEEGLSSDNVQKSKGVIENVGEIYSVKTAKDESMNEKIPLEKSSF 1205
Query: 3172 -NDENATEPKIQDTKIMDIIGRVDIDDEEVPEQLEKDQPEMEQNDRKELPPE-MKHEDLD 2999
+DE+ D ++ + DI +E P +E+ +ELP E + D+
Sbjct: 1206 VDDESFKGQGPTDNVSVEDVNSEDIINEHTP---------LEETKIEELPTEYITTADIH 1256
Query: 2998 FKGNGAQDVDGTPIEQIN--------QGSKMVQVTEVTHKDIKEEGCDFKDLGTI---ST 2852
+G + E+IN Q K+ + V + + E+ L
Sbjct: 1257 TRGE-TETKYNLIYEKINEEVEKAKFQEEKITENIPVERESVTEDIVQEPSLAQEVEQKE 1315
Query: 2851 GELAGIESSKEDNEAKKPEEEINE------GLD---IGGAEEDTGEHIVENDVILDHNRT 2699
+ IE +K NE PE + E GLD + +E E IVE +V
Sbjct: 1316 SDTNEIEETKLANEKIIPEVSVTENVVEKEGLDTEEVLEEDESITEEIVEEEVSACEEIV 1375
Query: 2698 TIQEEAIKDAHKEDKANEVLEIAGVGKDDGETVMEEDVVPDPSTTTIGEEPTKDGHEEDK 2519
+E + ++ +E++++ EI + E ++EE+ + S+ I EE ++ E+
Sbjct: 1376 EEEESSSEEIVEEEESSSE-EIVEEEESSSEEIVEEE---ESSSEEIVEE--EESSSEEI 1429
Query: 2518 VIEISKIDSVDKDIGESIIKENVVPDVSTTTIGEAQTKDVRE-EDKIIEGLNIDADEEVG 2342
+ E+S + V ++ G S+ +E V +VSTT + KD+ ++++E +E VG
Sbjct: 1430 IEEVSSTEEVLEEEG-SVTEEIVEEEVSTTE----EVKDIGSVSEEVLEEEGFGTEEFVG 1484
Query: 2341 D--SITKDVVQDQSTTTIGEETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPI 2168
S+ +++V+ +S+T E + EE V T +
Sbjct: 1485 QQGSVIEEIVETESSTEKVLEDVGSNVEE------IVQEEGPVAQEIVHEEVSTTEKHDE 1538
Query: 2167 KDGHEKEKIIEQPEIVGADREIREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEI 1988
D E+I+E+ V + + E E++V + S T EE +++ IN+V E +
Sbjct: 1539 VDRSTTEEIVEKVGSVSEEIIVEEVSASEEIVEEGSVT---EEVVEEEKLINEVGETESV 1595
Query: 1987 ASSNKDNGDPTIEGEVVPNHSITTIGEESTNDGQ--EEDKVVAELDIVDVHKXXXXXXXX 1814
+ ++ EV + +G+E + + + E++ +V E+ +
Sbjct: 1596 T-------EEIVQKEVSDAEEV--LGQEGSMNEEILEKESIVEEIVGPEGSVTEEIVDYG 1646
Query: 1813 XXXXXDHSTTTIGEEPIQDGPAENKVIEGLEKVDLDEHIGEH-----ITEKDVAPDHSIT 1649
+ EE +Q + + I+ E + +E I E I EK D +
Sbjct: 1647 SFAEEVKEEELVTEEAVQYEGSVTEEIKEEESITENEAIEESAFAEIIEEKGPNNDEIV- 1705
Query: 1648 SFEEEPIKDFHEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEK 1469
+EE + ++V E++ +K + + I+GEE ++ +P++ E
Sbjct: 1706 --KEEGLDTEEIVNEVSVTDEVIEEEKLVNEQIVGEE-------RSVTEKPVE---VERS 1753
Query: 1468 VIEELKIDGANK----DIGESSIKDVVLDQSTTSI---GETPVKDAHEEHKVRVGANKDI 1310
E+L +GA+ + E S + +LD+S E V D E +V V +
Sbjct: 1754 ATEDLVEEGASVTEKVSVHEGSTTEQILDESVAEEIVEEEVSVDDKIIEEEVSVDEVVEE 1813
Query: 1309 GEPIIKENVVLDH--PTKTIGEIKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHST 1136
+I+E V + P + + E EE E + + + V +
Sbjct: 1814 EGSVIEEIVEEEESVPEEILEEELSGSEEVLEDEWVTDAFMGQEGSVIEEIEEIVDGEGS 1873
Query: 1135 KTTWEEPTKDGH-EDKVIE----------GLE--IVDDVVPKPSTT--ITGEEAIRNGQE 1001
T EE +DG +K++E G E ++++++ + S + + + E
Sbjct: 1874 IT--EEIVEDGSANEKIVEEEPSRVEEVLGKEGFVIEEIIEEGSVIEQVEDTKTVSEKSE 1931
Query: 1000 ENKVIEELEIVDAEEDIGEPIIEKDVVPGHTTTIGEELI-NDVHDDNKVIEGFEMVGSDK 824
E+ IEE++ V EE I E I+EK+ ++ EE++ + K+++
Sbjct: 1932 ESSAIEEVKEVKEEESISEKIVEKE------ESVTEEIVRQEESTTEKIVKDVSPTEDFV 1985
Query: 823 DTGEPVVDDVIPEHSTTTSVGESIKDAH-XXXXXXXXXXIVGADKEIREPAIKEDVVPDL 647
+ + V + VI + + T V E +++ V A + ++ +++V ++
Sbjct: 1986 EQTDSVTEKVIEQEGSNTEVAEDVEEKESASDEHEQEDVSVNAQVTCEKKSVTKEIVDEV 2045
Query: 646 STTTREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHSTTIIGEESTNDGHEE 467
S T EE +++ V EG++ GS + EE+I + + T EE DG
Sbjct: 2046 SRT--EEIVEEN---GSVTEGVDETGS--------VTEEIIEEATVT---EEVVEDGSVT 2089
Query: 466 DKVV---AVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDL 296
++VV +V+ V D + E ++++N + EE +++ + N+ +E V
Sbjct: 2090 EEVVEDGSVIQEVVEDGSVTEEIVQEN-------GSVTEEIVEEEGSVNEEVEEEVSVSG 2142
Query: 295 DKDIGEPITEKDVAPDNFIAAFEEE---AIKDVHEEDKVIEETEIIGADKDIGDHIIGEE 125
+ D E +TE+ + + EE ++++ EE+ + E EI+ + + + I+ EE
Sbjct: 2143 EVDETEYVTEEVEEEGSVVEEIVEEEGSVVEEIVEEEGSVVE-EIVEEEGSVVEEIVEEE 2201
Query: 124 IVPDHSTTTIRGEPIQD-GHEEDKVTEEL 41
G +++ EE V EE+
Sbjct: 2202 GSVVEEIVEEEGSVVEEIVEEEGSVVEEI 2230
Score = 129 bits (325), Expect = 5e-27
Identities = 324/1637 (19%), Positives = 632/1637 (38%), Gaps = 201/1637 (12%)
Frame = -1
Query: 4315 IEDGHSLPPRMVEDSRR-AEELEVFQSFKNGIVNTNTEAKVGNXXXXXXXXXXXLAIKAS 4139
+ED S +VED EE+ +S + +T T A+ +
Sbjct: 2669 VEDEGSFTEEIVEDEGSFTEEVIEERSLIEEVEDTETVAEKEEGSVIKEIIDEKSLTEKI 2728
Query: 4138 DELFKAFKDSEDKVKPILTKTQEPESERQMQKDQTNDTVE-------ATGDIIKGDKIDS 3980
E K+ + ++ + + + +E + + T VE DI+ ++I
Sbjct: 2729 VEEEKSVTEEVEEKESVKEEVEEQRLVVEEEGSATEGIVEDRLATEGIVDDILVTEEIVE 2788
Query: 3979 CG----EHALKKMSLDSARADNVGLVNSSALSTAPNDDDNIGEKLPAVPITSVSDDLN-V 3815
G E ++ S+ D+ G V + + ++ I E V + D++ V
Sbjct: 2789 DGLATDEFVEQQGSIIEEVLDDEGSVTEEIVEEEGSPNEEIVE---GVSVIEEDDNIEPV 2845
Query: 3814 QEGQTEGGNGADMDDMEQKNDVIFDD---------KQAPVVEHL-QSGDIIRHHLVGNSK 3665
E EG +M +N+VI D+ K+ V E + + + +V +
Sbjct: 2846 SEEIVEGSVTEEMIKEGLENEVILDEDSITEEALEKEGSVSEEIVEEMGSLTEEIVDEER 2905
Query: 3664 EVNGDQLTEGICASQSIEEDKAVTSSHEDQTEGTESGEDPDLKSGXXXXXXXXXXXEYYD 3485
+ D + EG + + I+E+ V E+ + E E+ +L + ++
Sbjct: 2906 STSEDMIEEGSASEEIIQEESQVEEVVEEVSVIDEIVEEDELDTKEVVEEIE------FN 2959
Query: 3484 KEKVVADDLYTHNISIEEVKQSGFQEKELECKEQSSNSMGMVKDPEKIGQMEDRDYENKE 3305
E+VV +++ EE+ Q +EKE E+ +G + + +M ++D + E
Sbjct: 2960 TEEVVEHKEEEGSVA-EEIVQ---EEKEGSVNEEIIEEVGSITE-----EMVEQDVSDNE 3010
Query: 3304 GVKMVTEETSLQKSEVEESWSPDNTHSHLLDETSLKPIDLQKERNDENATEPKIQDTKIM 3125
+ EE S+ + E W LD + ID + +++ E I + +
Sbjct: 3011 EI---VEERSVIEEAEENVWIEKEVEEEGLDNEEV--IDEEDSVSEQAEEEVYINEEILK 3065
Query: 3124 DIIGRVDIDDEEVPEQLEKDQPEMEQNDRKELPPEMKHEDLDFKGNGAQDVDGTPIEQIN 2945
+ D++D +V +L + E N+ + E ED + ++ + E +
Sbjct: 3066 E---SSDVEDVKVENELMNE----EVNEETQSVAENNEEDKELDNYVVEETESVTEEVVV 3118
Query: 2944 Q---GSKMVQVTEVTHKDIKEEGCDFKDL---------------GTISTG--ELAGIESS 2825
SK VQ E ++I E+G DL G+ S G E A I
Sbjct: 3119 DEVPNSKEVQEIESIIEEIVEDGLTTDDLVGQQGSVIEEVVEEVGSDSEGIVEEASITEE 3178
Query: 2824 KEDNEAKKP----EEEINEGLDIGGA--EEDTGEHIVENDVILDHNRTTIQEEAIKDAHK 2663
E E+ EE + + + G+ EE GE + ++ I+ + QE +DA
Sbjct: 3179 VEKKESVTEDILVEESVTGDILVEGSVTEEVVGEEKLVSEEIVTEEGSVAQEIVEEDAPA 3238
Query: 2662 EDKANEVLEIAGV-----GKDDGETVMEEDVVPDP---STTTIGEEPTKDGHEEDKVI-- 2513
++ +E+ + G D E V EE V + + + E + G E +++
Sbjct: 3239 TEEIDEIESVTEEVVEEEGPVDEEIVQEEGSVTEEIIQGESKVEEVVEEQGSENEEIFVE 3298
Query: 2512 ------EISKIDSVDKDIGESI-IKENVVPDVSTTTIGEAQTKDVREE------------ 2390
EI + +S ++I E + + +V D S T + K V EE
Sbjct: 3299 EVSASQEIVQNESGTEEILEKVSASQEIVQDGSVTEQIIEEQKPVTEEVVNEEESITHEI 3358
Query: 2389 -------DKIIEGLNIDADEEVGD--SITKDVVQDQSTTT--IGEETIKCGHEEERELXX 2243
+K+++ ++ A+E V + S+T+++V+ + + T IG+E E E
Sbjct: 3359 IQEESHVEKVVQQGSV-AEEVVENPVSVTEEIVEKEGSVTEDIGQEGYVAEEIVEEE--- 3414
Query: 2242 XXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKI----IEQPEIVGADREIREPVIEED- 2078
+ EE +++G + E+I I EIV + + E V+EE+
Sbjct: 3415 -------EFDNEEILEEESVAEEFVEEGFDNEEIFVEQISDSEIVKEENSVNEEVLEEEG 3467
Query: 2077 ----VVPDLSTTTTREEPIQDGHDINKVIE-----GLEIASSNKDNGDPTIEGE------ 1943
+ + + T E ++G +++E EI + +E E
Sbjct: 3468 SYTEEILEEEGSYTEEILEEEGSFTEEILEEEGSYNEEILEEEGSYNEEILEEEGSFTEE 3527
Query: 1942 VVPNHSITT---IGEESTND-----GQEEDKVVAELDIV---------DVHKXXXXXXXX 1814
++ T +G+ S N+ G D V + I+ D K
Sbjct: 3528 ILEEEGSATDYFVGQGSDNEEIIEEGSATDYFVGQGSIIEEVLEEEGLDTEKVFENEGSA 3587
Query: 1813 XXXXXDHSTTTIGEEP--IQDGPAENKVIEGLEKVD-LDEHIGEHITEKDVAPDH-SITS 1646
S T + EE + + E I ++K++ + E I E + +++ +
Sbjct: 3588 TEFEETESFTEVVEETESVNENILEETSINEVQKIESITEDIKEQLVPEEIKEEQLDSEE 3647
Query: 1645 FEEEPIKDFHEEDKVIEGTEI---------VGADKDIGDPIIGEEIVPDH-STTTIRGEP 1496
+EE + +++ ++ EI + ++ + I E++VP+ + E
Sbjct: 3648 IKEEQLDSEEIKEEQLDSEEIKEEQLVPEEIKEEQLDSEEIKEEQLVPEEIKEEQLNSEE 3707
Query: 1495 IQDDHEEEKVIEELKIDGANKDIGESSIKDVVLDQSTTSIGETPVKD------------- 1355
I+++ + + I+E ++D +++I E + + + S+ E V++
Sbjct: 3708 IKEEQLDSEEIKEEQLD--SEEIKEEQLDSEEIKEQKGSVNEEVVEEEGSVTEEIKEQEE 3765
Query: 1354 -AHEEHKVRVGANKDIGEPIIKENVVLDHPTKTIGEIKDKHEEDKVIEG---LDNDCVNX 1187
+EE V + I E I++ + + + K+ EE+ VI+ +D V
Sbjct: 3766 SVNEEVLEEVEETESIKEEIVEGGIATQEIIEEESDTKEVVEEE-VIDSEKLVDAGSVTG 3824
Query: 1186 XXXXXXXXXXG--VREHSTKTTWEEPTKDGHEDKVIEGLEIVDDVVPKPSTTITGEEAIR 1013
V E ST E K +E+ V +GL I D V + STT EE +
Sbjct: 3825 EVMPEEVSVTDEVVEEGSTTEEVLEEQKSVNEEVVEDGLTIDDFVGLQGSTT---EEVVE 3881
Query: 1012 -NGQEENKVIEEL----EIVDAEEDIGEPIIEKDVVPGHTTTIGEELINDVHDDNKVIEG 848
+G K++EE EIV+ + + E I+EK+ ++ EE+I + ++I+G
Sbjct: 3882 EDGSAIEKILEEETATEEIVEKQVSVTEDIVEKE------GSVNEEIIEEASVAEEIIQG 3935
Query: 847 FEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAHXXXXXXXXXXIVGADKEIREPAIK 668
E ++VI E ++ E ++ V D E+ E ++
Sbjct: 3936 GSFTEEIVGQEESATEEVIDEEGLISNEIEEEEEKSVTEEMIEEVEEVSVDDEVEEVSVA 3995
Query: 667 EDVVPDLSTTTREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDH--------S 512
E++V EE + D ++ ++ + D I++EE + + S
Sbjct: 3996 EEIV-------EEELVDDEILPEELSATEDVIEEVRSVTDEIVQEESVCEEILEQEVSAS 4048
Query: 511 TTIIGEESTND---GHEEDKVVAVLDIVGVDKDIGE---PVIEDNVVPNHSTT------- 371
+ ++S D GHE + V + V ++I E VIE+ V S T
Sbjct: 4049 EEYVDDKSVTDDFVGHERSVIQDVENTESVTEEIAEVDKSVIEEAVEKQGSVTEEIVEEE 4108
Query: 370 ------------TTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPITEKDVAPDNFIAAFE 227
TG+ Q+G +++ E E + D + + E+D + E
Sbjct: 4109 ELDTEEVLEDKSVTGDVVEQEGSGKDE-SEAKESFTEEVDELKSVKEEDQETEYISREIE 4167
Query: 226 EEAIKDVHEEDKVIEETEIIGAD---KDIGDH-IIGEEIVPDHSTTTIRGEPIQDGHEED 59
EE+ + H E ++ E++ + KDI + +EI+ + T ++ E +++ + D
Sbjct: 4168 EESATEQHSEQELSINKEVVETESLTKDIEEEKSTTQEILEE--TQSVNEEIVEEERDTD 4225
Query: 58 KVTEELKIDGAKKDIGE 8
+V +E K+ +++ I E
Sbjct: 4226 EVLKE-KVSPSEEVIEE 4241
Score = 119 bits (297), Expect = 1e-23
Identities = 276/1336 (20%), Positives = 546/1336 (40%), Gaps = 126/1336 (9%)
Frame = -1
Query: 3778 MDDMEQKNDVIFDDKQAPVVEHLQS-GDIIRHHLVGNSKEVNGDQLTEGICASQSIEEDK 3602
+++ E N+ I ++ V+ ++S + I+ LV +E+ +QL S+ I+E++
Sbjct: 3600 VEETESVNENILEETSINEVQKIESITEDIKEQLV--PEEIKEEQLD-----SEEIKEEQ 3652
Query: 3601 AVTSSHEDQTEGTESGEDPDLKSGXXXXXXXXXXXEYYDKEKVVADDLYTHNISIEEVKQ 3422
S E + E +S E + + E +E++V +++ ++ EE+K+
Sbjct: 3653 L--DSEEIKEEQLDSEEIKEEQLVPEEIKEEQLDSEEIKEEQLVPEEIKEEQLNSEEIKE 3710
Query: 3421 SGFQEKELECKEQSSNSMGMVK-DPEKIGQMEDRDYENKEGVK---MVTEETSLQKSEVE 3254
+E++ ++ S + + D E+I E + N+E V+ VTEE Q+ V
Sbjct: 3711 EQLDSEEIKEEQLDSEEIKEEQLDSEEI--KEQKGSVNEEVVEEEGSVTEEIKEQEESVN 3768
Query: 3253 ESWSPDNTHSHLLDETSLKPIDLQKERNDENATEPKIQDTKIMDIIGRVD---IDDEEVP 3083
E + + + E ++ +E +E + ++ + +++D VD + E +P
Sbjct: 3769 EEVLEEVEETESIKEEIVEGGIATQEIIEEESDTKEVVEEEVIDSEKLVDAGSVTGEVMP 3828
Query: 3082 EQLEKDQPEMEQN--------DRKELPPEMKHEDL---DF---KGNGAQDV---DGTPIE 2954
E++ +E+ ++K + E+ + L DF +G+ ++V DG+ IE
Sbjct: 3829 EEVSVTDEVVEEGSTTEEVLEEQKSVNEEVVEDGLTIDDFVGLQGSTTEEVVEEDGSAIE 3888
Query: 2953 QINQGS--------KMVQVTE-------VTHKDIKEEGCDFKDL--GTISTGELAGIESS 2825
+I + K V VTE +++I EE +++ G T E+ G E S
Sbjct: 3889 KILEEETATEEIVEKQVSVTEDIVEKEGSVNEEIIEEASVAEEIIQGGSFTEEIVGQEES 3948
Query: 2824 K---------------EDNEAKKPEEEINEGLD----------IGGAEEDTGEHIVENDV 2720
E+ E K EE+ E ++ + AEE E +V++++
Sbjct: 3949 ATEEVIDEEGLISNEIEEEEEKSVTEEMIEEVEEVSVDDEVEEVSVAEEIVEEELVDDEI 4008
Query: 2719 ILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVGKD--DGETVMEEDVVPDPSTTTIGEEP 2546
+ + T E+ I++ +E+++ V ++ + E E+ V D S T
Sbjct: 4009 LPEELSAT--EDVIEEVRSV--TDEIVQEESVCEEILEQEVSASEEYVDDKSVTD----- 4059
Query: 2545 TKDGHEEDKVIEISKIDSVDKDIGE---SIIKENVVPDVSTTT-IGEAQTKDVRE--EDK 2384
GHE + ++ +SV ++I E S+I+E V S T I E + D E EDK
Sbjct: 4060 DFVGHERSVIQDVENTESVTEEIAEVDKSVIEEAVEKQGSVTEEIVEEEELDTEEVLEDK 4119
Query: 2383 IIEGLNIDAD------EEVGDSITKDVVQDQSTTTIGEETIKCGHEEERELXXXXXXXXX 2222
+ G ++ + E +S T++V + +S +ET E E E
Sbjct: 4120 SVTGDVVEQEGSGKDESEAKESFTEEVDELKSVKEEDQETEYISREIEEESATEQHSEQE 4179
Query: 2221 XXXXXXXXAVPATGEEPIKDGHEKEKIIEQP-----EIVGADREIREPVIE-----EDVV 2072
+ ++ ++ ++I+E+ EIV +R+ E + E E+V+
Sbjct: 4180 LSINKEVVETESLTKDIEEEKSTTQEILEETQSVNEEIVEEERDTDEVLKEKVSPSEEVI 4239
Query: 2071 PDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNGDPTIEGEVVPNHSITTIGEESTND 1892
+ ++TT EE +++ ++++E ++ + + ++ E+V S T GE +
Sbjct: 4240 EEQASTT--EEFLEERSSTDEIVEVEDLFTEEVKEREGSVTEEIVEEGSDT--GEIVEEE 4295
Query: 1891 GQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTTTIGEEPIQDGPAEN------KVIE 1730
G + ++++ E + +I EE +Q E VIE
Sbjct: 4296 GSDAEEILEEGSFNE--------------EIVEEEGSITEEILQGSVTEEFVGQQGSVIE 4341
Query: 1729 GLEKVD--LDEHIGEHITEKDVAPDHSITSFEEEPIKDFHEEDKVIEGT--EIVGADKDI 1562
+ + + ++E + + ++V S+T EE + D+V+EG+ E++ + +
Sbjct: 4342 EIVETESAIEERVEDESATEEVDERESVTEVVEEEVSS---SDEVVEGSIEEVIENEGSV 4398
Query: 1561 GDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEEL--KIDGANKDIGESSIKDVVLDQS 1388
+ I+ E+ D + I++ E V EE+ + + +++I E S + V+ Q
Sbjct: 4399 TEEILEHEVSADENFVGQAVSVIEEVEGTESVTEEVVEETESVSEEIVEVSPTENVVQQ- 4457
Query: 1387 TTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDHPTKTIGEIKDKHEEDKVIEGL 1208
T S+ E V+ + +++G+ ++E ++K ++V+ G
Sbjct: 4458 TDSVIEEDVEQKEGSFNEEIDI-RELGDDGVEE--------------REKISTEEVV-GQ 4501
Query: 1207 DNDCVNXXXXXXXXXXXGVREHSTKTTWEE--PTKDGHEDKVIEGLEIVDDVVPKPSTTI 1034
D V E S+ EE T+D E EGLE V
Sbjct: 4502 DKSATGD-----------VEESSSTGDVEEVSSTEDEEEVSSTEGLEEVSST-------- 4542
Query: 1033 TGEEAIRNGQEENKVIEELEIVDAEEDIGEPIIEKDVVPGHTTTIGEELINDVHDDNKVI 854
G EE E++E V + ED+ E + ++V + T + D+ D +
Sbjct: 4543 -------EGLEEVSNTEDVEEVSSTEDVEEGSVAENVKETKSITEEVSVEEDIITDKVSV 4595
Query: 853 EGFEMVGSDKDTGEPVVDDVIPEHSTTTSVGESIKDAHXXXXXXXXXXIVGADKEIREPA 674
E + V ++ E ++ +V E T S++D IV D + E
Sbjct: 4596 E--QEVMAEASVEENILTEVPVEEEIMTEK-LSVEDKALNEKIMSEEEIVIEDGNVHEVV 4652
Query: 673 IKE----DVVPDLSTTTREEPIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHSTT 506
E + +P + TT E G ++ E+ D D I ++ D S
Sbjct: 4653 PAEVSVTEEIPGVEETTNNESHVKGENVVN-----EVVVDDNSVNDEIQFDD---DSSIE 4704
Query: 505 IIGEESTNDGHEEDKVVAVLDIVGVDKDI------GEPVI-----EDNVVPNHSTTTTGE 359
I +S + H+E+ + + V D++I E + E + V + T T +
Sbjct: 4705 IYTVDSKDVFHKEENYDSFREEVRSDENIHISRKKNENFVKKIENEKSSVGHVPTEYTSK 4764
Query: 358 EPIQDGQA------ENKVIEGLEKVDLDKDIGEPITEKDVAPDNFIAAFEEEAIKDVHEE 197
E I + EN E ++V +++ E + E+ + +N I EEA D++ E
Sbjct: 4765 ENIAEEVPSHIMFKENVTEEVPKEVKYEENTVEEVFEEVTSKENII----EEAPGDINSE 4820
Query: 196 DKVIEETEIIGADKDI 149
+ +IEE + ++I
Sbjct: 4821 ENIIEEVPEVVTSEEI 4836
Score = 103 bits (257), Expect = 4e-19
Identities = 285/1334 (21%), Positives = 528/1334 (39%), Gaps = 52/1334 (3%)
Frame = -1
Query: 3889 PNDDDNIGEKLPAVPITSVSDDLNVQEGQTEGGNGADMDDMEQKNDVIFDDKQAPVVEHL 3710
P ++ ++ E++P V SVS+++ V+E ++ +E+KN ++ PV E
Sbjct: 166 PVEEKSVSEEIP-VEEKSVSEEIPVEEKSV-----SEEIPVEEKNV----SEEIPVEEKN 215
Query: 3709 QSGDI-IRHHLVGNSKEVNGDQLTEGICASQSIEEDKAVTSSHEDQTEGTESGEDPDLKS 3533
S +I + V V + ++E I +EE+ S E E E ++
Sbjct: 216 VSEEIPVEEKNVSEEIPVEEENVSEEI----PVEEENV---SEEIPVE--EENVSEEIPE 266
Query: 3532 GXXXXXXXXXXXEYYDKEKVVADDLYTHNISIEEVKQSGFQEKELECKEQSSNSMGMVKD 3353
G E +E V + +Y + E ++ EQ S+ V
Sbjct: 267 GGIAIEDVPVDEETVTEEITVDEKIYDKLPNEIETVNEEMPVEDETLTEQISSEHERV-- 324
Query: 3352 PEKIGQMEDRDYENKEGVKMVTEETSLQKSEVEESWSPDNTHSHLLDETSLKPID--LQK 3179
PE+I +E++ + E + +T+E VEE D+ + ++ + +
Sbjct: 325 PEEI--IEEKPFTEGEETESLTDEI------VEEGVVTDDIPEEQIITEKVQEEEEFVTG 376
Query: 3178 ERNDENATEPKIQ--DTKIMDIIGRVDIDDEEVPEQLEKDQPEMEQNDRKELPPEMK--- 3014
E ++E+ K+Q D + + + DI +E+V E+ E E+ Q+ E K
Sbjct: 377 ELSEEDIINEKVQEEDESVTEELPEEDIINEKVQEEEESAYQEIVQDGSVTKDVEYKELV 436
Query: 3013 HEDLDFKGNGAQDVDGTPIEQINQGSKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGI 2834
++D+ K N + D + IN+G + + +KEE F++L
Sbjct: 437 NDDVRDKENFVIEEDPFKGQLINEGLPVEEEFVTKELPVKEESV-FEEL----------- 484
Query: 2833 ESSKEDNEAKK--PEEEINEGLDIGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKE 2660
++ED K P EE + ++ E T E IVE + ++ ++EE +
Sbjct: 485 --TEEDQSVTKEIPVEEHSVFKEVDEIESVT-EEIVEEEGSVNEE---VEEEVSVSGEVD 538
Query: 2659 DKANEVLEIAGVGKDDGETVMEEDVVPDPSTTTIGEEPTKDGHEEDKVIEISKIDSVDKD 2480
+ E+ + E + EE + G K EE V E + + + ++
Sbjct: 539 ETEYVTEEVEETELVNEEVLKEEGSASEKVVKEEGSASEKIVEEEGSVTEETASEEIVEE 598
Query: 2479 IG---ESIIKENVVPDVSTTTIGEAQTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQ 2309
G E E +V D + T + + V EE +IE + E S +K++V+D+
Sbjct: 599 EGSVTEESSSEEIVEDEGSVTEESSSEEIVEEEGSVIEESASEVIVEDEVSASKEIVEDE 658
Query: 2308 STTTIGEETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEKIIEQ- 2132
++ T EE + EEE + + +E I G E I+EQ
Sbjct: 659 ASVT--EEVV----EEEGAV------------SDEVQVTESVEDEIINQGIVDEVIVEQE 700
Query: 2131 ----PEIVGADREIREPV-IEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDN 1967
EIV D + E + +EE V + T +E I D V+E +E K
Sbjct: 701 ASVTDEIVKEDESVIEEIAVEETVTEVVEETKPMDEEIVDQ---GSVVENVE----EKKT 753
Query: 1966 GDPTI--EGEVVPN-HSITTIGEESTNDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXD 1796
D I +G VV N T+ EE + G +KV E ++
Sbjct: 754 MDEEIVDQGSVVENVEEKKTMDEEIGDQGSVAEKVEEE----ELVTEEVIEREGSINEDI 809
Query: 1795 HSTTTIGEEPIQDGPAENKVIEGLEKVD-LDEHIGEHITEKDVAPDHSITSFEEEPIKDF 1619
+I EE Q P KV EK++ + + I E + +D+ + FEE +
Sbjct: 810 VKEASITEEVEQIEPVTGKV----EKIESITDEIKEQLVPEDIKEEQ--LDFEEIVAQRA 863
Query: 1618 HEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGA 1439
D+ +E I + + + + EE++ + +TT + +++ E V+EE
Sbjct: 864 SVNDEKVEVASIT-EEVEEEEKSVSEEVLEEEGSTT--EKVVEEGSSTEVVVEE------ 914
Query: 1438 NKDIGESSIKDVVLDQSTTSIGETPVKDAHEEHKV--RVGANKDIGEPIIKENVVLDHPT 1265
+ S+ + VL++ G T + E+ V + + + I+++ +D
Sbjct: 915 -----QGSVSEEVLEEE----GSTTEEVVEEQGSVTENLLEEESASQGIVEKEEFVDEE- 964
Query: 1264 KTIGEIKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVI 1085
+KD++ +K EG + + E E+ K+ ++
Sbjct: 965 ---DSVKDQNVFEK--EGSVTE--------------QLVEEEKGLINEDNEKEELITEMS 1005
Query: 1084 EGLEIVDDVVPKPSTTITGEEAIRNGQEENKVIEELEIVDAEEDIGEPIIEKDVVPGHTT 905
E ++ V++ + + T ++ EE I+ + + E V+ E+ + + ++E++ V T
Sbjct: 1006 EEIKSVNEEIEE--TDLSTEEIIK-----QQGLATYEFVEEEKSLTDKLLEEESV---TK 1055
Query: 904 TIGE-ELINDVHDDNKVIEGFEMVGSDKDTGEPVV------DDVIPEHSTTTSVGESIKD 746
+GE EL D KV E++ +K E V+ ++V+ E S T V E D
Sbjct: 1056 EVGETELSTQEVVDEKVSVTEEVIEEEKSVSEEVLEEGSATEEVVEEGSCTEIVVEKGSD 1115
Query: 745 AHXXXXXXXXXXIV-----GADKEIREPAIKEDVVPDLSTTTREEPIQDG---HDINKVG 590
IV + + E ++ E+++ + + T EE +++G ++ K
Sbjct: 1116 TEIVVEEGSATEIVVEEGSATEVVVEEGSVSEEMLEEEGSAT-EEVVEEGLSSDNVQKSK 1174
Query: 589 EGLEIAG---SDKDNGDPIIEEEVIPDHSTTIIGEESTNDGHEEDKV----VAVLDIVGV 431
+E G S K D + E+ IP ++ + +ES D V V DI+
Sbjct: 1175 GVIENVGEIYSVKTAKDESMNEK-IPLEKSSFVDDESFKGQGPTDNVSVEDVNSEDIINE 1233
Query: 430 DKDIGEPVIED---NVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDIGEPITEKD 260
+ E IE+ + T GE + K+ E +EK + E ITE
Sbjct: 1234 HTPLEETKIEELPTEYITTADIHTRGETETKYNLIYEKINEEVEKAKFQE---EKITEN- 1289
Query: 259 VAPDNFIAAFEEEAIKDVHEEDKVIEETEIIGADKDIGDH--IIGEEIVPDHSTTTIRGE 86
I E +D+ +E + +E E +D + + + E+I+P+ S T E
Sbjct: 1290 ------IPVERESVTEDIVQEPSLAQEVEQKESDTNEIEETKLANEKIIPEVSVTENVVE 1343
Query: 85 PIQDGHEEDKVTEE 44
++G + ++V EE
Sbjct: 1344 --KEGLDTEEVLEE 1355
Score = 101 bits (252), Expect = 2e-18
Identities = 207/974 (21%), Positives = 400/974 (41%), Gaps = 31/974 (3%)
Frame = -1
Query: 2836 IESSKEDNEAKK--PEEEINEGLDIGGAEE-----DTGEHIVENDVILDHNRTTIQEEAI 2678
+E ++++NE +K E + E + G EE + + +EN++I+DH I+EE
Sbjct: 19 MEETEKENEIEKIMDENKETEQTEEGNTEEFVQEKELNQETLENEIIVDH----IKEE-- 72
Query: 2677 KDAHKEDKANEVLEIAGVGKDDGETVMEEDVVPD-PSTTTIGEEPTKDGHEEDKVIEISK 2501
ED N + E+V+EE + + P IG+ + EE + EI
Sbjct: 73 -----EDTRN---------VKEQESVLEESPIEELPVENNIGK--INEEVEEFILNEIPL 116
Query: 2500 IDSVDKDIGESIIKENVVPDVSTTTIGEAQTKDVREEDKIIEGLNIDADEEVGD-SITKD 2324
+ V K++ + I+E VV ++ ++ V EED +G I+ ++ V + S++++
Sbjct: 117 EEQVPKELPQEEIEEIVVEELPIDEHLSSEETTVTEED-TFKGQLINEEKPVEEKSVSEE 175
Query: 2323 VVQDQSTTTIGEETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGEEPIKDGHEKEK 2144
+ ++ ++ EE EE+ + + E P+++ + E+
Sbjct: 176 IPVEEK--SVSEEI----PVEEKSV---------------------SEEIPVEEKNVSEE 208
Query: 2143 IIEQPEIVGADREIREPVIEEDVVPDLSTTTTREEPIQDGHDINKVIEGLEIASSNKDNG 1964
I + + V + + E + E+ +P + E P+++ + ++ E S G
Sbjct: 209 IPVEEKNVSEEIPVEEKNVSEE-IPVEEENVSEEIPVEEENVSEEIPVEEENVSEEIPEG 267
Query: 1963 DPTIEGEVVPNHSITTIGEESTNDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTT 1784
IE V ++T EE T D + DK+ E++ V+ +H
Sbjct: 268 GIAIEDVPVDEETVT---EEITVDEKIYDKLPNEIETVNEEMPVEDETLTEQISSEHE-- 322
Query: 1783 TIGEEPIQDGPAENKVIEGLEKVDL-DEHIGEHITEKDVAPDHSIT----SFEEEPIKDF 1619
+ EE I++ P EG E L DE + E + D+ + IT EE +
Sbjct: 323 RVPEEIIEEKP----FTEGEETESLTDEIVEEGVVTDDIPEEQIITEKVQEEEEFVTGEL 378
Query: 1618 HEEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRGEPIQDDHEEEKVIEELKIDGA 1439
EED + E ++ D+ + + + E+I+ E +Q+ EEE +E+ DG+
Sbjct: 379 SEEDIINE--KVQEEDESVTEELPEEDII---------NEKVQE--EEESAYQEIVQDGS 425
Query: 1438 -NKDIG-ESSIKDVVLDQSTTSIGETPVKDAHEEHKVRVGANKDIGEPIIKENVVLDHPT 1265
KD+ + + D V D+ I E P K G + G P+ +E V + P
Sbjct: 426 VTKDVEYKELVNDDVRDKENFVIEEDPFK----------GQLINEGLPVEEEFVTKELPV 475
Query: 1264 KTIGEIKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVI 1085
K ++ EED+ + V EHS +E + ++++
Sbjct: 476 KEESVFEELTEEDQSV----------------TKEIPVEEHSVFKEVDE--IESVTEEIV 517
Query: 1084 EGLEIVDDVVPKPSTTITGE----EAIRNGQEENKVIEELEIVDAEEDIGEPIIEKDVVP 917
E V++ V + +++GE E + EE +++ E E++ E E +++++
Sbjct: 518 EEEGSVNEEV-EEEVSVSGEVDETEYVTEEVEETELVNE-EVLKEEGSASEKVVKEEGSA 575
Query: 916 GHTTTIGEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDD---VIPEHSTTTSVGESIKD 746
E + + +++E V +++ + E +V+D V E S+ V E
Sbjct: 576 SEKIVEEEGSVTEETASEEIVEEEGSV-TEESSSEEIVEDEGSVTEESSSEEIVEEEGSV 634
Query: 745 AHXXXXXXXXXXIVGADKEI--REPAIKEDVVPDLSTTTREEPIQDGHDINKVGEGLEIA 572
V A KEI E ++ E+VV + + E + + + + +G
Sbjct: 635 IEESASEVIVEDEVSASKEIVEDEASVTEEVVEEEGAVSDEVQVTESVEDEIINQG---- 690
Query: 571 GSDKDNGDPIIEEEVIPDHSTTIIGEESTNDGHEEDKVV---AVLDIVGVDKDIGEPVIE 401
I +EVI + ++ E D +++ V ++V K + E +++
Sbjct: 691 ----------IVDEVIVEQEASVTDEIVKEDESVIEEIAVEETVTEVVEETKPMDEEIVD 740
Query: 400 D-NVVPNHSTTTTGEEPIQDGQAENKVIEGL-EKVDLDKDIGEPITEKDVAPDNFIAAFE 227
+VV N T +E I D + V+E + EK +D++IG+ +
Sbjct: 741 QGSVVENVEEKKTMDEEIVD---QGSVVENVEEKKTMDEEIGD----------------Q 781
Query: 226 EEAIKDVHEEDKVIEETEIIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEE-DKVT 50
+ V EE+ V E E+I + I + I+ E + + EP+ E+ + +T
Sbjct: 782 GSVAEKVEEEELVTE--EVIEREGSINEDIVKEASITEEVEQI---EPVTGKVEKIESIT 836
Query: 49 EELKIDGAKKDIGE 8
+E+K +DI E
Sbjct: 837 DEIKEQLVPEDIKE 850
>gb|ACJ64146.1| sporozoite-specific transmembrane protein S6 precursor [Plasmodium
berghei]
Length = 2301
Score = 127 bits (320), Expect = 2e-26
Identities = 260/1221 (21%), Positives = 493/1221 (40%), Gaps = 87/1221 (7%)
Frame = -1
Query: 3445 ISIEEVKQSGFQEKELECKEQSSNSMGMV-KDPEKIGQMEDRDYENKEGVKMVTEETSLQ 3269
I + +KQ+G EK++ E +++S G + K+P I +E + + + + +
Sbjct: 474 IEKDHLKQNGEVEKKIS--ETNNDSDGNITKNPTDIQILEKKQLKGNNKHTDDSIDGAQD 531
Query: 3268 KSEVEESWSPDNTHSHLLDETSLKPIDLQKERNDENATEPKIQDTKIMDII------GRV 3107
+ E + +N +D+ + K I + +N E K I + G V
Sbjct: 532 WDKYEGNVIVENKEMKGIDKNTDK-ITIDNNMKVDNTYEMK--GALIYTTVEREGNNGSV 588
Query: 3106 DIDDEEVPEQLEKDQPEMEQNDRKELPPEMKHEDLDFKGNGAQDVDGTPIEQINQGSKMV 2927
+ + +++ ++ E+ + E+N+ K++ P+ + + K + + + +I Q +
Sbjct: 589 EPNKQKLSKEKEELESNKEKNEDKQIFPDKTKSETEKKDK--EIIRDQELNKITQNGNVE 646
Query: 2926 QVTEVTHKDIKEEGCDFKDLG-------TISTGELAGIESSKEDNEAKKPEEEI--NEGL 2774
+ EV + ++K L I E +E K +E++ EE I +E
Sbjct: 647 NIVEVIPAHETKTVEEYKPLDESRVVEEVIPVHETKTVEEYKPLDESRVVEEVIPVHETK 706
Query: 2773 DIGGAEEDTGEHIVENDVILDHNRTTIQEEAIKDAHKEDKANEVLEIAGVG--KDDGETV 2600
+ + ++E LD +T + + + ++ ++ V E V K E+
Sbjct: 707 TVEEYKPLYESRVIEEHKPLDETKTVEEYKPLDESRVVEEVIPVNETKTVEEYKPLYESR 766
Query: 2599 MEEDVVPDPSTTTIGE-EPTKDGH--EEDKVIEISKIDSVDKDIGESIIKENVVPDVSTT 2429
+ E+ P T T+ E +P + EE K ++ +K K + ES + E P T
Sbjct: 767 VIEEYKPLDETKTVEEYKPLYESRVIEEYKPLDETKTVEEYKPLYESRVIEGYKPLYETK 826
Query: 2428 TIGEA----------------QTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTT 2297
T+ E +TK V E + E I+ + + ++ T + + +
Sbjct: 827 TVEEYKPLYESRVIEEHKPLDETKTVEEYKPLYESRVIEEHKPLDETKTVEEYKPLDESR 886
Query: 2296 IGEETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGE-EPIKDGHEKEKII--EQPE 2126
+ EE I + E E +P+ + E +I + +
Sbjct: 887 VVEEVIPVNETKTVEEYKPLNESRVIEEYKPLDETKTVEEYKPLDESRVVEDVIPVHETK 946
Query: 2125 IVGADREIREPVIEEDVVPDLSTTTTRE-EPIQDGHDINKVIEGLEIASSN--KDNGDPT 1955
V + + E + E+V+P T T E +P+ + + VI E + K +
Sbjct: 947 TVEEYKPLDESRVIEEVIPVHETKTVEEYKPLYESRVVEDVIPVHETKTVEEYKPLDESR 1006
Query: 1954 IEGEVVPNHSITTIGEEST---NDGQEEDKVVAELDIVDVHKXXXXXXXXXXXXXDHSTT 1784
+ EV+P H T+ E + EE K + E V+ +K H T
Sbjct: 1007 VVEEVIPVHETKTVEEYKPLYESRVIEEHKPLDETKTVEEYKPLDESRVVEEVIPVHETK 1066
Query: 1783 TIGE-EPIQDGPA--ENKVIEGLEKVDLDEHIGEHITEKDVAPDHSITSFEE-EPIKDFH 1616
T+ E +P+ + E+K ++ + V+ + + E +DV P H + EE +P+ +
Sbjct: 1067 TVEEYKPLYESRVIEEHKPLDETKTVEEYKPLDESRVVEDVIPVHETKTVEEYKPLDESR 1126
Query: 1615 EEDKVI--EGTEIVGADKDIGDPIIGEEIVPDHSTTTIRG-EPIQDDH--EEEKVIEELK 1451
++VI T+ V K + + + EE++P + T T+ +P+ + EE K ++E K
Sbjct: 1127 VVEEVIPVHETKTVEEYKPLDESRVVEEVIPVNETKTVEEYKPLYESRVIEEYKPLDETK 1186
Query: 1450 IDGANKDIGESSIKDVV--LDQSTTSIGETPVKDAH--EEHKVRVGANKDIGE--PIIKE 1289
K + ES + + LD++ T P+ + EE+K + K + E P+ +
Sbjct: 1187 TVEEYKPLYESRVIEEYKPLDETKTVEEYKPLYGSRVIEEYKP-LDETKTVEEYKPLYES 1245
Query: 1288 NVVLDHP----TKTIGEIKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVRE-----HST 1136
V+ + TKT+ E K +E V E + + V E H T
Sbjct: 1246 RVIEGYKPLYETKTVEEYKPLYESRVVEEVIPVNETKTVEEYKPLDESRVVEDVIPVHET 1305
Query: 1135 KTTWEEPTKDGHEDKVIEGLEIVDDVVPKPSTTITGEEAIRNGQEENKVIEEL------E 974
KT E K ++ +V++V+P T E E++V+EE+ +
Sbjct: 1306 KTV--------EEYKPLDESRVVEEVIPVHETKTVEEY---KPLYESRVVEEVIPVNETK 1354
Query: 973 IVDAEEDIGEPIIEKDVVPGHTTTIGEELINDVHDDNKVIEGFEMVGSDKDTGEPVVDDV 794
V+ + + E + +DV+P H T EE D+++V+E ++ + + VV++V
Sbjct: 1355 TVEEYKPLDESKVVEDVIPVHETKTVEEY--KPLDESRVVEEYKPLDESR-----VVEEV 1407
Query: 793 IPEHSTTTSVGESIKDAHXXXXXXXXXXI-----VGADKEIREPAIKEDVVPDLSTTTRE 629
IP H T + E K + + V K + E + E+ P T T E
Sbjct: 1408 IPVHET--KIVEEYKPLYESRVIEEYKPLDETKTVEEYKPLYESRVIEEHKPLDETKTVE 1465
Query: 628 E--PIQDGHDINKVGEGLEIAGSDKDNGDPIIEEEVIPDHSTTIIGEEST---NDGHEED 464
E P+ + + + K + + EEVIP H T + E + EE
Sbjct: 1466 EYKPLDESRVVEEY----------KPLNESRVVEEVIPVHETKTVEEYKPLYESRVIEEH 1515
Query: 463 KVVAVLDIVGVDKDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENKVIEGLEKVDLDKDI 284
K + V K + E + + V+ H T T E D E++VI+ + D ++ +
Sbjct: 1516 KPLDETKTVEEYKPLNESRVVEEVIHAHETKTVEEYKPLD---ESRVIDEHKLFDENRVV 1572
Query: 283 GEPITEKDVAPDNFIAAFEEEAIKDVHEEDKVIEETEIIGADKDIGDHIIGEEIVPDHST 104
E I + + ++ V +ED ET+ + K + + I+ EE++P H T
Sbjct: 1573 EEVIPAHETKK---VEEYKPLYGSRVIDEDIPAYETKTVDEHKPLDESIVVEEVIPVHET 1629
Query: 103 TTI-RGEPIQDGHEEDKVTEE 44
TI +P+ +E +V EE
Sbjct: 1630 KTIDEHKPL----DESRVIEE 1646
Score = 95.9 bits (237), Expect = 9e-17
Identities = 252/1208 (20%), Positives = 450/1208 (37%), Gaps = 113/1208 (9%)
Frame = -1
Query: 3298 KMVTEETSLQKSEVEESWSPDNTHSHLLDETSLKPIDLQKERNDENATEPKIQDTKIMDI 3119
K V E L +S V E + P LDET K ++ K ++ E I + +
Sbjct: 898 KTVEEYKPLNESRVIEEYKP-------LDET--KTVEEYKPLDESRVVEDVIPVHETKTV 948
Query: 3118 IGRVDIDDEEVPEQLEKDQPEMEQNDRKELPPEMKHEDLDFKGNGAQDVDGTPIEQINQG 2939
+D+ V E++ + K L ED+ + P+++
Sbjct: 949 EEYKPLDESRVIEEVIPVHETKTVEEYKPLYESRVVEDVIPVHETKTVEEYKPLDESRVV 1008
Query: 2938 SKMVQVTEVTHKDIKEEGCDFKDLGTISTGELAGIESSKEDNEAKKPEEEINEGLDIGGA 2759
+++ V E K ++E +K L E IE K +E K EE
Sbjct: 1009 EEVIPVHET--KTVEE----YKPLY-----ESRVIEEHKPLDETKTVEEY---------- 1047
Query: 2758 EEDTGEHIVENDVILDHNRTTIQE------EAIKDAHKE-DKANEVLEIAGVGKDDGETV 2600
+ E V +VI H T++E + + HK D+ V E K E+
Sbjct: 1048 -KPLDESRVVEEVIPVHETKTVEEYKPLYESRVIEEHKPLDETKTVEEY----KPLDESR 1102
Query: 2599 MEEDVVPDPSTTTIGE-EPTKDGHEEDKVIEISKIDSVD--KDIGESIIKENVVPDVSTT 2429
+ EDV+P T T+ E +P + ++VI + + +V+ K + ES + E V+P T
Sbjct: 1103 VVEDVIPVHETKTVEEYKPLDESRVVEEVIPVHETKTVEEYKPLDESRVVEEVIPVNETK 1162
Query: 2428 TIGEA----------------QTKDVREEDKIIEGLNIDADEEVGDSITKDVVQDQSTTT 2297
T+ E +TK V E + E I+ + + ++ T + + +
Sbjct: 1163 TVEEYKPLYESRVIEEYKPLDETKTVEEYKPLYESRVIEEYKPLDETKTVEEYKPLYGSR 1222
Query: 2296 IGEETIKCGHEEERELXXXXXXXXXXXXXXXXXAVPATGE-EPIKDGHEKEKII--EQPE 2126
+ EE + E E +P+ + E++I + +
Sbjct: 1223 VIEEYKPLDETKTVEEYKPLYESRVIEGYKPLYETKTVEEYKPLYESRVVEEVIPVNETK 1282
Query: 2125 IVGADREIREPVIEEDVVPDLSTTTTRE-EPIQDGHDINKVIEGLEIASSN--KDNGDPT 1955
V + + E + EDV+P T T E +P+ + + +VI E + K +
Sbjct: 1283 TVEEYKPLDESRVVEDVIPVHETKTVEEYKPLDESRVVEEVIPVHETKTVEEYKPLYESR 1342
Query: 1954 IEGEVVPNHSITTIGEESTNDGQ---------------EEDKVVAELDIVDVHKXXXXXX 1820
+ EV+P + T+ E D EE K + E +V+ +K
Sbjct: 1343 VVEEVIPVNETKTVEEYKPLDESKVVEDVIPVHETKTVEEYKPLDESRVVEEYKPLDESR 1402
Query: 1819 XXXXXXXDHSTTTIGE-EPIQDGPAENKVIEGLEKVDLDEHIGEH--ITEKDVAPDHSIT 1649
H T + E +P+ E++VIE + +D + + E+ + E V +H
Sbjct: 1403 VVEEVIPVHETKIVEEYKPLY----ESRVIEEYKPLDETKTVEEYKPLYESRVIEEH--- 1455
Query: 1648 SFEEEPIKDFH--EEDKVIEGTEIVGADKDIGDPIIGEEIVPDHSTTTIRG-EPIQDDH- 1481
+P+ + EE K ++ + +V K + + + EE++P H T T+ +P+ +
Sbjct: 1456 ----KPLDETKTVEEYKPLDESRVVEEYKPLNESRVVEEVIPVHETKTVEEYKPLYESRV 1511
Query: 1480 -EEEKVIEELKIDGANKDIGESSIKDVVLDQSTTS-------IGETPVKDAH-------- 1349
EE K ++E K K + ES + + V+ T + E+ V D H
Sbjct: 1512 IEEHKPLDETKTVEEYKPLNESRVVEEVIHAHETKTVEEYKPLDESRVIDEHKLFDENRV 1571
Query: 1348 -------------EEHKVRVGA-----------------NKDIGEPIIKENVVLDHPTKT 1259
EE+K G+ +K + E I+ E V+ H TKT
Sbjct: 1572 VEEVIPAHETKKVEEYKPLYGSRVIDEDIPAYETKTVDEHKPLDESIVVEEVIPVHETKT 1631
Query: 1258 IGEIKDKHEEDKVIEGLDNDCVNXXXXXXXXXXXGVREHSTKTTWEEPTKDGHEDKVIEG 1079
I E K +E +VIE + + TKT D H K+ +
Sbjct: 1632 IDEHKPL-DESRVIE------------------EDIPAYETKTV------DKH--KLFDE 1664
Query: 1078 LEIVDDVVPKPSTTITGEEAIRNGQEENKVIEELEIVDAEEDIGEPIIEKDVVPGHTTTI 899
+V++V+P + E + + + N +I + GE I + ++ G+
Sbjct: 1665 SRVVEEVIPAYESKTVDERKLVDSIDANDIIGK----------GESIYDNKIIQGN---- 1710
Query: 898 GEELINDVHDDNKVIEGFEMVGS--------DKDTGEPVVDDVIPEHSTTTSVGESIKDA 743
+E I+D + + ++G+E S D + G+ + + + ST+ + + K
Sbjct: 1711 -DEWISDKDEAIENLDGYESTKSTNYSDNSDDNEEGKSIFPNKNIDLSTSNVINDQSK-- 1767
Query: 742 HXXXXXXXXXXIVGADKEIREPAIKEDVVPDLSTTTREEPIQDGHDINKVGEGLEIAGSD 563
I+ DK + + I D ++ T +R+E IQ + NK ++
Sbjct: 1768 -----------IIYTDKSVNK-TINSDPNENIHTESRKEDIQKESENNK-----DMISHI 1810
Query: 562 KDNGDPIIEEEVIPDHSTTIIGEESTNDGHEEDKVVAVLDIVGVDKDIGEPVIEDNVVPN 383
D D II +I E++ D +D + VD G + +
Sbjct: 1811 PD--DRIIHRVANNGEKKLLIDEKNIEDILGKD--------LNVDNSEGGSNEYNTIDME 1860
Query: 382 HSTTTTGEE--PIQDGQAENKVIEGLEKVDLDKDIGEPI-TEKDVAPDNF--IAAFEEEA 218
H +T +E I+ K+ E + DK I ++D P + I ++EA
Sbjct: 1861 HKEDSTLDEHNNIEKNDNNGKISEHSSE---DKSYTIDIKVDRDTLPHDSINIQKTKDEA 1917
Query: 217 IKDVHEEDKVIEETEIIGADKDIGDHIIGEEIVPDHSTTTIRGEPIQDGHEEDKVTEELK 38
E D +E I + DI GE + + +GE + E D +E
Sbjct: 1918 AIKKEEADTKKDEAAIKKEEVDIKK---GEAAIKKYEVDIKKGEAVIKKEEADTKKDEAA 1974
Query: 37 IDGAKKDI 14
I + DI
Sbjct: 1975 IKKEEVDI 1982
Score = 86.3 bits (212), Expect = 7e-14
Identities = 148/649 (22%), Positives = 259/649 (39%), Gaps = 64/649 (9%)
Frame = -1
Query: 1762 QDGPAENKVIEGLEKVDLDEHIGEHITEKDVAPD--------HSITSFEEEPIKDFHEED 1607
Q+G E K+ E D D +I ++ T+ + H+ S + D +E +
Sbjct: 481 QNGEVEKKISE--TNNDSDGNITKNPTDIQILEKKQLKGNNKHTDDSIDGAQDWDKYEGN 538
Query: 1606 KVIEGTEIVGADKDIGDPIIGEEIVPDHST--------TTIRGEPIQDDHE--------E 1475
++E E+ G DK+ I + D++ TT+ E E E
Sbjct: 539 VIVENKEMKGIDKNTDKITIDNNMKVDNTYEMKGALIYTTVEREGNNGSVEPNKQKLSKE 598
Query: 1474 EKVIEELKIDGANKDI--------GESSIKDVVLDQSTTSIGET-------PVKDAHEEH 1340
++ +E K +K I E K+++ DQ I + V AHE
Sbjct: 599 KEELESNKEKNEDKQIFPDKTKSETEKKDKEIIRDQELNKITQNGNVENIVEVIPAHETK 658
Query: 1339 KVRVGANKDIGEPIIKENVVLDHPTKTIGEIKDKHEEDKVIEGLD-NDCVNXXXXXXXXX 1163
V K + E + E V+ H TKT+ E K E V E + ++
Sbjct: 659 TVE--EYKPLDESRVVEEVIPVHETKTVEEYKPLDESRVVEEVIPVHETKTVEEYKPLYE 716
Query: 1162 XXGVREHSTKTTWEEPTKDGHEDKVIEGLEIVDDVVPKPSTTITGEEAIRNGQEENKVIE 983
+ EH + TK E K ++ +V++V+P T E E++VIE
Sbjct: 717 SRVIEEHKPL----DETKTVEEYKPLDESRVVEEVIPVNETKTVEEY---KPLYESRVIE 769
Query: 982 ELEIVDAEEDIGE--PIIEKDVVPGHTTTIGEELINDVHD--DNKVIEGFEMVGSDKDTG 815
E + +D + + E P+ E V+ + + + + +++VIEG++ + K
Sbjct: 770 EYKPLDETKTVEEYKPLYESRVIEEYKPLDETKTVEEYKPLYESRVIEGYKPLYETKTVE 829
Query: 814 E--PVVDD-VIPEHSTT--TSVGESIKDAHXXXXXXXXXXI-----VGADKEIREPAIKE 665
E P+ + VI EH T E K + + V K + E + E
Sbjct: 830 EYKPLYESRVIEEHKPLDETKTVEEYKPLYESRVIEEHKPLDETKTVEEYKPLDESRVVE 889
Query: 664 DVVPDLSTTTREE--PIQDGHDIN--KVGEGLEIAGSDKDNGDPIIEEEVIPDHSTTIIG 497
+V+P T T EE P+ + I K + + K + + E+VIP H T +
Sbjct: 890 EVIPVNETKTVEEYKPLNESRVIEEYKPLDETKTVEEYKPLDESRVVEDVIPVHETKTVE 949
Query: 496 E-ESTNDGHEEDKVVAVLDIVGVD--KDIGEPVIEDNVVPNHSTTTTGEEPIQDGQAENK 326
E + ++ ++V+ V + V+ K + E + ++V+P H T T E D E++
Sbjct: 950 EYKPLDESRVIEEVIPVHETKTVEEYKPLYESRVVEDVIPVHETKTVEEYKPLD---ESR 1006
Query: 325 VIEGLEKVDLDKDIGEPITEKDVAPDNFIAAFEEEAIKDVHEEDKVIEETEIIGADKDIG 146
V+E + V K + E + +E I EE K ++ET+ + K +
Sbjct: 1007 VVEEVIPVHETKTVEE-----------YKPLYESRVI----EEHKPLDETKTVEEYKPLD 1051
Query: 145 DHIIGEEIVPDHSTTTIRG-EPIQDGH--EEDKVTEELKIDGAKKDIGE 8
+ + EE++P H T T+ +P+ + EE K +E K K + E
Sbjct: 1052 ESRVVEEVIPVHETKTVEEYKPLYESRVIEEHKPLDETKTVEEYKPLDE 1100