BLASTX 2.2.26 [Sep-21-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Chrysanthemum22_contig00012484
         (2335 letters)

Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects 
           149,584,005 sequences; 54,822,741,787 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gb|OTG25011.1| putative DNA-repair protein [Helianthus annuus]        163   2e-51
gb|KVI11807.1| DNA recombination and repair protein Rad51, C-ter...   154   3e-51
ref|XP_022037955.1| DNA repair protein XRCC3 homolog [Helianthus...   163   9e-51
ref|XP_021977342.1| DNA topoisomerase 2-like [Helianthus annuus]...   202   4e-50
ref|XP_022005320.1| DNA topoisomerase 2-like [Helianthus annuus]...   199   3e-49
gb|PLY87541.1| hypothetical protein LSAT_8X66820 [Lactuca sativa]     145   5e-48
ref|XP_023761164.1| DNA repair protein XRCC3 homolog [Lactuca sa...   145   5e-48
ref|XP_020113224.1| DNA topoisomerase 2-like [Ananas comosus]         188   6e-48
ref|XP_023759895.1| DNA topoisomerase 2 [Lactuca sativa]              193   3e-47
gb|PLY88472.1| hypothetical protein LSAT_1X105720 [Lactuca sativa]    191   1e-46
ref|XP_012455307.1| PREDICTED: DNA topoisomerase 2 isoform X2 [G...   188   1e-45
ref|XP_012455306.1| PREDICTED: DNA topoisomerase 2 isoform X1 [G...   188   1e-45
gb|KHG03878.1| DNA topoisomerase 2 -like protein [Gossypium arbo...   187   2e-45
gb|PPD78478.1| hypothetical protein GOBAR_DD24581 [Gossypium bar...   187   2e-45
ref|XP_017619617.1| PREDICTED: DNA topoisomerase 2 isoform X2 [G...   187   2e-45
ref|XP_017619616.1| PREDICTED: DNA topoisomerase 2 isoform X1 [G...   187   2e-45
ref|XP_016722313.1| PREDICTED: DNA topoisomerase 2 isoform X2 [G...   187   2e-45
ref|XP_016722312.1| PREDICTED: DNA topoisomerase 2 isoform X1 [G...   187   2e-45
ref|XP_018621925.1| PREDICTED: DNA topoisomerase 2 isoform X2 [N...   187   2e-45
ref|XP_018621924.1| PREDICTED: DNA topoisomerase 2 isoform X1 [N...   187   2e-45

>gb|OTG25011.1| putative DNA-repair protein [Helianthus annuus]
          Length = 373

 Score =  163 bits (413), Expect(2) = 2e-51
 Identities = 91/150 (60%), Positives = 110/150 (73%), Gaps = 4/150 (2%)
 Frame = -1

Query: 439 TLLTTPLHFTAPNHP*RPQRLLVISLH---EFPFPYRRFTQLVHSFQSTHPILFESARDP 269
           T L+  L FTA      P  L   SL+   EFPFPYRRF QL+HSF+S+HPILF + RDP
Sbjct: 125 TQLSLQLLFTAQ----LPHGLSGSSLYLYSEFPFPYRRFAQLLHSFRSSHPILFANYRDP 180

Query: 268 QDYIYTREVHDAHQLFDILSHLSFCLEN-KATKLDVKMIVIDSIAALFRSEFENNARDLK 92
            D+I+TR+ H AH L D+L  L   L++ K T+LD+K+IVIDSIAALFRSEFENN  DLK
Sbjct: 181 CDHIFTRDCHTAHHLLDVLLQLESRLKHPKETRLDIKLIVIDSIAALFRSEFENNGADLK 240

Query: 91  KRCDLFFRISACLKGIAKRFGVAVVVTNQV 2
           KR  LFF+IS+ LK  AKRFG+AVV+TNQV
Sbjct: 241 KRSALFFKISSVLKMYAKRFGIAVVITNQV 270



 Score = 70.5 bits (171), Expect(2) = 2e-51
 Identities = 34/48 (70%), Positives = 38/48 (79%)
 Frame = -2

Query: 588 QMNPQNLLIRPPPT*FCTLGCPILDKALGGGIPTNSITELVSESGCGK 445
           QM P+NLL+        +LGCPILD ALGGGIP+NSITELVSESGCGK
Sbjct: 77  QMQPENLLLHHTHHHHLSLGCPILDAALGGGIPSNSITELVSESGCGK 124


>gb|KVI11807.1| DNA recombination and repair protein Rad51, C-terminal [Cynara
           cardunculus var. scolymus]
          Length = 299

 Score =  154 bits (389), Expect(2) = 3e-51
 Identities = 78/120 (65%), Positives = 95/120 (79%), Gaps = 1/120 (0%)
 Frame = -1

Query: 358 EFPFPYRRFTQLVHSFQSTHPILFESARDPQDYIYTREVHDAHQLFDILSHLSFCLEN-K 182
           EFPFP RRF QL+ SF+ +HPILF S+RDP+DYI+TR+   A  L D+L  L   LE  K
Sbjct: 77  EFPFPNRRFNQLLESFRLSHPILFASSRDPRDYIFTRDCQTAQDLLDVLLLLESRLEKPK 136

Query: 181 ATKLDVKMIVIDSIAALFRSEFENNARDLKKRCDLFFRISACLKGIAKRFGVAVVVTNQV 2
            T+LD+K+IVIDSIAALFRSEFENN RDLK+R  LFF+IS+ LK  AKRFG+A+V+TNQV
Sbjct: 137 ETRLDIKLIVIDSIAALFRSEFENNPRDLKRRSSLFFKISSLLKSHAKRFGIAIVLTNQV 196



 Score = 79.3 bits (194), Expect(2) = 3e-51
 Identities = 40/69 (57%), Positives = 44/69 (63%)
 Frame = -2

Query: 585 MNPQNLLIRPPPT*FCTLGCPILDKALGGGIPTNSITELVSESGCGKXXXXXXXXXXXXX 406
           M P +LL+RP  T +CTLGCPILD  LGGGIP NSITELVSESGCGK             
Sbjct: 1   MRPDSLLLRPANTQYCTLGCPILDAFLGGGIPCNSITELVSESGCGKTQLSLQLLFTAQL 60

Query: 405 XXTHNGLNG 379
               NGL+G
Sbjct: 61  PLHLNGLSG 69


>ref|XP_022037955.1| DNA repair protein XRCC3 homolog [Helianthus annuus]
          Length = 296

 Score =  163 bits (413), Expect(2) = 9e-51
 Identities = 91/150 (60%), Positives = 110/150 (73%), Gaps = 4/150 (2%)
 Frame = -1

Query: 439 TLLTTPLHFTAPNHP*RPQRLLVISLH---EFPFPYRRFTQLVHSFQSTHPILFESARDP 269
           T L+  L FTA      P  L   SL+   EFPFPYRRF QL+HSF+S+HPILF + RDP
Sbjct: 48  TQLSLQLLFTAQ----LPHGLSGSSLYLYSEFPFPYRRFAQLLHSFRSSHPILFANYRDP 103

Query: 268 QDYIYTREVHDAHQLFDILSHLSFCLEN-KATKLDVKMIVIDSIAALFRSEFENNARDLK 92
            D+I+TR+ H AH L D+L  L   L++ K T+LD+K+IVIDSIAALFRSEFENN  DLK
Sbjct: 104 CDHIFTRDCHTAHHLLDVLLQLESRLKHPKETRLDIKLIVIDSIAALFRSEFENNGADLK 163

Query: 91  KRCDLFFRISACLKGIAKRFGVAVVVTNQV 2
           KR  LFF+IS+ LK  AKRFG+AVV+TNQV
Sbjct: 164 KRSALFFKISSVLKMYAKRFGIAVVITNQV 193



 Score = 68.6 bits (166), Expect(2) = 9e-51
 Identities = 33/47 (70%), Positives = 37/47 (78%)
 Frame = -2

Query: 585 MNPQNLLIRPPPT*FCTLGCPILDKALGGGIPTNSITELVSESGCGK 445
           M P+NLL+        +LGCPILD ALGGGIP+NSITELVSESGCGK
Sbjct: 1   MQPENLLLHHTHHHHLSLGCPILDAALGGGIPSNSITELVSESGCGK 47


>ref|XP_021977342.1| DNA topoisomerase 2-like [Helianthus annuus]
 gb|OTG37224.1| putative topoisomerase II [Helianthus annuus]
          Length = 1499

 Score =  202 bits (513), Expect = 4e-50
 Identities = 133/329 (40%), Positives = 175/329 (53%), Gaps = 38/329 (11%)
 Frame = -3

Query: 2333 MLPWYNGFKGEIEKTETPSKDTLYTTKGMIEV--DNNGITITELPVGTWTKVYEKSLK-- 2166
            M PWY  FKG I+KT   SKDT YTT G+ E   DNN + ITELP+  WT+ Y++ L+  
Sbjct: 871  MDPWYKWFKGTIQKTT--SKDTGYTTVGVFEENEDNNSLNITELPIRRWTQEYKEFLEAA 928

Query: 2165 SRVGNDIKAYTPRHGKTNN---VHFEITMTNEQMKSAKEGGILNKFKLTTTLSTANMHML 1995
            S  G D + +   +   N+   VHFE+ MT  QM  AKE G+L KFKLTTTLST+NMH+ 
Sbjct: 929  SLSGKDKEPFIEEYNAHNDDTTVHFEVVMTANQMNKAKEEGLLKKFKLTTTLSTSNMHLF 988

Query: 1994 GLDDQLKKYDTPDEILEDFYHFRLKLYEKRRSARXXXXXXXXXXXXXXXXLICKVRDGEY 1815
              +  +KKYDTP++ILEDF+H RL  YEKR++A                  I +V +G  
Sbjct: 989  DANGVIKKYDTPEQILEDFFHLRLDYYEKRKNALLHELGKASLQLENKVRFIREVVEGT- 1047

Query: 1814 LVFPPKEKEERCAELMDKGFQS-------SQAIAYEVHPVERKATKEEELK--------- 1683
            LV   ++K + CAEL  KG+           +IA  V  VE     EE  +         
Sbjct: 1048 LVVSNRKKADLCAELKVKGYTPLPKEAVLEASIAGAVDHVEGSEETEEGSEEETAEMAVE 1107

Query: 1682 ---------------TGYDYLLSTPIVSFSAEKIKELEKEMGAKKIELRELDNTSAKSLW 1548
                           T YDYLLS  I + + EK+++L  E   KK E  EL NT +KSLW
Sbjct: 1108 EQKPSAGTASKTIPGTEYDYLLSMAIGTLTYEKMQQLWHERDTKKAEFDELTNTPSKSLW 1167

Query: 1547 LKDLDALIRQLDAEKYPSAKRAPDAARPQ 1461
            L+DLD+L  QLD +    AK   +  + Q
Sbjct: 1168 LRDLDSLNNQLDEQDKRDAKDEAERRKQQ 1196


>ref|XP_022005320.1| DNA topoisomerase 2-like [Helianthus annuus]
 gb|OTF98638.1| putative DNA topoisomerase 2 [Helianthus annuus]
          Length = 1488

 Score =  199 bits (506), Expect = 3e-49
 Identities = 133/331 (40%), Positives = 174/331 (52%), Gaps = 40/331 (12%)
 Frame = -3

Query: 2333 MLPWYNGFKGEIEKTETPSKDTLYTTKGMIEV--DNNGITITELPVGTWTKVYEKSLK-- 2166
            M PWY  FKG I+KT   SKDT YTT G +E   D N ++ITELP+  WT+ Y++ L+  
Sbjct: 858  MDPWYKWFKGTIQKTT--SKDTGYTTIGNVEEKEDENALSITELPIRRWTQEYKEFLEAA 915

Query: 2165 SRVGNDIKAYTPRHGKTNN---VHFEITMTNEQMKSAKEGGILNKFKLTTTLSTANMHML 1995
            S  G D + +   +   N+   VHFE+ MT  QM  AKE G+L KFKLTTTLST+NMH+ 
Sbjct: 916  SLSGKDKEPFIEEYNAHNDDTTVHFEVIMTASQMNKAKEEGLLKKFKLTTTLSTSNMHLF 975

Query: 1994 GLDDQLKKYDTPDEILEDFYHFRLKLYEKRRSARXXXXXXXXXXXXXXXXLICKVRDGEY 1815
              +  +KKYDTP++ILEDF+H RL  YEKR+ A                  I +V +G  
Sbjct: 976  DANGVIKKYDTPEQILEDFFHLRLDFYEKRKVALLHELGKASLILENKVRFIREVVEGT- 1034

Query: 1814 LVFPPKEKEERCAELMDKGFQS-------SQAIAYEVHPVERKATKEEELKTG------- 1677
            +V   ++K + CAEL  KGF           +IA  V  VE     EEE  +G       
Sbjct: 1035 IVVSNRKKADLCAELKVKGFTPLPKEAVLEASIAGAVDHVEGSDETEEEEGSGSPADVAA 1094

Query: 1676 -------------------YDYLLSTPIVSFSAEKIKELEKEMGAKKIELRELDNTSAKS 1554
                               YDYLLS  I + + EK+K+L  E   KK E  EL NT +KS
Sbjct: 1095 VEEEKSHVGTASKTIPGTEYDYLLSMAIGTLTYEKMKQLWHERDTKKAEFDELTNTPSKS 1154

Query: 1553 LWLKDLDALIRQLDAEKYPSAKRAPDAARPQ 1461
            LWL+DL+AL  QLD +     K   +  + Q
Sbjct: 1155 LWLRDLNALSDQLDEQDKRDVKDEAERRKQQ 1185


>gb|PLY87541.1| hypothetical protein LSAT_8X66820 [Lactuca sativa]
          Length = 301

 Score =  145 bits (366), Expect(2) = 5e-48
 Identities = 84/150 (56%), Positives = 104/150 (69%), Gaps = 4/150 (2%)
 Frame = -1

Query: 439 TLLTTPLHFTAPNHP*RPQRLLVISLH---EFPFPYRRFTQLVHSFQSTHPILFESARDP 269
           T L+  L FTA   P     L   SL+   E+PFP RR  QLV SF+S+HPILF S+RDP
Sbjct: 48  TQLSLQLLFTA-QLPLHLNGLSASSLYLYSEYPFPNRRLDQLVESFRSSHPILFASSRDP 106

Query: 268 QDYIYTREVHDAHQLFDILSHLSFCLEN-KATKLDVKMIVIDSIAALFRSEFENNARDLK 92
           +DYI+TR    A  L D+L  L   LE  K T+LD+K+IVIDSIAALFRS+F+NN  DLK
Sbjct: 107 RDYIFTRNCQTAQDLLDVLLLLESRLEKPKETRLDIKLIVIDSIAALFRSDFDNNPADLK 166

Query: 91  KRCDLFFRISACLKGIAKRFGVAVVVTNQV 2
           +R  LFF+IS+ LK  A+R G+A+VVTNQV
Sbjct: 167 RRSSLFFKISSILKSHARRRGIAIVVTNQV 196



 Score = 77.4 bits (189), Expect(2) = 5e-48
 Identities = 36/47 (76%), Positives = 39/47 (82%)
 Frame = -2

Query: 585 MNPQNLLIRPPPT*FCTLGCPILDKALGGGIPTNSITELVSESGCGK 445
           M P+NLL RP  T +CTLGCPILD  LGGGIP NSITELV+ESGCGK
Sbjct: 1   MTPENLLHRPTHTQYCTLGCPILDAFLGGGIPCNSITELVAESGCGK 47


>ref|XP_023761164.1| DNA repair protein XRCC3 homolog [Lactuca sativa]
          Length = 300

 Score =  145 bits (366), Expect(2) = 5e-48
 Identities = 84/150 (56%), Positives = 104/150 (69%), Gaps = 4/150 (2%)
 Frame = -1

Query: 439 TLLTTPLHFTAPNHP*RPQRLLVISLH---EFPFPYRRFTQLVHSFQSTHPILFESARDP 269
           T L+  L FTA   P     L   SL+   E+PFP RR  QLV SF+S+HPILF S+RDP
Sbjct: 48  TQLSLQLLFTA-QLPLHLNGLSASSLYLYSEYPFPNRRLDQLVESFRSSHPILFASSRDP 106

Query: 268 QDYIYTREVHDAHQLFDILSHLSFCLEN-KATKLDVKMIVIDSIAALFRSEFENNARDLK 92
           +DYI+TR    A  L D+L  L   LE  K T+LD+K+IVIDSIAALFRS+F+NN  DLK
Sbjct: 107 RDYIFTRNCQTAQDLLDVLLLLESRLEKPKETRLDIKLIVIDSIAALFRSDFDNNPADLK 166

Query: 91  KRCDLFFRISACLKGIAKRFGVAVVVTNQV 2
           +R  LFF+IS+ LK  A+R G+A+VVTNQV
Sbjct: 167 RRSSLFFKISSILKSHARRRGIAIVVTNQV 196



 Score = 77.4 bits (189), Expect(2) = 5e-48
 Identities = 36/47 (76%), Positives = 39/47 (82%)
 Frame = -2

Query: 585 MNPQNLLIRPPPT*FCTLGCPILDKALGGGIPTNSITELVSESGCGK 445
           M P+NLL RP  T +CTLGCPILD  LGGGIP NSITELV+ESGCGK
Sbjct: 1   MTPENLLHRPTHTQYCTLGCPILDAFLGGGIPCNSITELVAESGCGK 47


>ref|XP_020113224.1| DNA topoisomerase 2-like [Ananas comosus]
          Length = 536

 Score =  188 bits (478), Expect = 6e-48
 Identities = 129/345 (37%), Positives = 177/345 (51%), Gaps = 26/345 (7%)
 Frame = -3

Query: 2333 MLPWYNGFKGEIEKTETPSKDTLYTTKGMIE-VDNNGITITELPVGTWTKVYEKSLKSRV 2157
            M PWY GFKG IEK+ T      YT  G+IE VDN  + I ELPV  WT+ Y++ L++ +
Sbjct: 171  MDPWYRGFKGLIEKSATKEAGVTYTITGIIEEVDNTTLRIMELPVRRWTQDYKEFLEALM 230

Query: 2156 -GND------IKAYTPRHGKTNNVHFEITMTNEQMKSAKEGGILNKFKLTTTLSTANMHM 1998
             GND      IK Y   H     VHFE+T+T E +  A + G+  KFKLTTT+ T NMH+
Sbjct: 231  TGNDKVKEPFIKDYR-EHNDDTTVHFEVTLTEENLNIALQEGLEKKFKLTTTIGTTNMHL 289

Query: 1997 LGLDDQLKKYDTPDEILEDFYHFRLKLYEKRRSARXXXXXXXXXXXXXXXXLICKVRDGE 1818
               +  +KKYDTP++ILEDF+H RL+ YEKR+                    I  V  GE
Sbjct: 290  FDSNGVIKKYDTPEQILEDFFHLRLEFYEKRKKVLLDNLEMDLLKLDNKVRFILGVVRGE 349

Query: 1817 YLVFPPKEKEERCAELMDKGFQSSQAIAYEVHPVERKATKEEE-------------LKTG 1677
             +V   +++ E   EL  KGF      +  +      AT EEE               + 
Sbjct: 350  IIV-NNRKRAELFIELHQKGFTPFPKKSKGIDVAIVGATTEEEENEESPEMGKGGVRASD 408

Query: 1676 YDYLLSTPIVSFSAEKIKELEKEMGAKKIELRELDNTSAKSLWLKDLDALIRQLDAEKYP 1497
            Y+YLLS  I + + EK++EL  E    + E+ EL   + +SLWLKDLDAL R+L+ ++  
Sbjct: 409  YEYLLSMAIGTLTLEKVQELCGERDKLESEVEELRKATPRSLWLKDLDALERELEEQERK 468

Query: 1496 SAKRAPDAARPQRAN-----*KSHSDEEEPEDDNDATEDSDFEDE 1377
             A+ A  A R  RA        S    ++P  +     +SD EDE
Sbjct: 469  DAE-ADGARRAMRAKNIGAAAASKQGAKKPRKNTSKAVESDDEDE 512


>ref|XP_023759895.1| DNA topoisomerase 2 [Lactuca sativa]
          Length = 1508

 Score =  193 bits (490), Expect = 3e-47
 Identities = 129/321 (40%), Positives = 177/321 (55%), Gaps = 30/321 (9%)
 Frame = -3

Query: 2333 MLPWYNGFKGEIEKTETPSKDTLYTTKGMIEVDN--NGITITELPVGTWTKVYEKSLK-- 2166
            M PWY  F+G I+KT   SKDT YTT G+++ D   N + ITELPV  WT+ Y++ L+  
Sbjct: 872  MDPWYKWFRGTIQKTA--SKDTGYTTTGIVDEDEDENTLRITELPVRRWTQEYKEFLEVA 929

Query: 2165 SRVGNDIKAYTPRHGKTNN---VHFEITMTNEQMKSAKEGGILNKFKLTTTLSTANMHML 1995
            S  G D + +   +   N+   V+F+I MT +QM  A++ G+L KFKLTTTLST+NMH+ 
Sbjct: 930  STAGKDKEPFIEEYNAHNDDTTVNFQIIMTADQMNKARQEGLLKKFKLTTTLSTSNMHLF 989

Query: 1994 GLDDQLKKYDTPDEILEDFYHFRLKLYEKRRSARXXXXXXXXXXXXXXXXLICKVRDGEY 1815
              +  +KKYDTP++ILEDF+  RL  YE+R++A                  I +V +G  
Sbjct: 990  DANGVIKKYDTPEQILEDFFPLRLDYYERRKTALLRELGKISLTLENKVRFIKEVVEGT- 1048

Query: 1814 LVFPPKEKEERCAELMDKGFQS-------SQAIAYEVHPVE-RKATKEEELK-------- 1683
            LV   ++K +  AEL  K +           +IA  V  VE  + T+EEE          
Sbjct: 1049 LVVSNRKKADLYAELAKKKYTPLPKEAVIEASIAGAVDHVEGSEETEEEEASDVPIDVEA 1108

Query: 1682 -------TGYDYLLSTPIVSFSAEKIKELEKEMGAKKIELRELDNTSAKSLWLKDLDALI 1524
                   T YDYLLS  I S + EK+K+L KE   KK E  EL NT ++SLWLKDLD L 
Sbjct: 1109 AAAXIPGTEYDYLLSMAIASLTYEKMKQLWKERDEKKAEFDELTNTPSRSLWLKDLDDLD 1168

Query: 1523 RQLDAEKYPSAKRAPDAARPQ 1461
            +QLD +    AK   +  + Q
Sbjct: 1169 KQLDEQDKRDAKDEAERKKQQ 1189


>gb|PLY88472.1| hypothetical protein LSAT_1X105720 [Lactuca sativa]
          Length = 1508

 Score =  191 bits (486), Expect = 1e-46
 Identities = 128/321 (39%), Positives = 176/321 (54%), Gaps = 30/321 (9%)
 Frame = -3

Query: 2333 MLPWYNGFKGEIEKTETPSKDTLYTTKGMIEVDN--NGITITELPVGTWTKVYEKSLK-- 2166
            M PWY  F+G I+KT   SKDT YTT G+++ D   N + ITELPV  WT+ Y++ L+  
Sbjct: 872  MDPWYKWFRGTIQKTA--SKDTGYTTTGIVDEDEDENTLRITELPVRRWTQEYKEFLEVA 929

Query: 2165 SRVGNDIKAYTPRHGKTNN---VHFEITMTNEQMKSAKEGGILNKFKLTTTLSTANMHML 1995
            S  G D + +   +   N+   V+F+I MT +QM  A++ G+L KFKLTTTLST+NMH+ 
Sbjct: 930  STAGKDKEPFIEEYNAHNDDTTVNFQIIMTADQMNKARQEGLLKKFKLTTTLSTSNMHLF 989

Query: 1994 GLDDQLKKYDTPDEILEDFYHFRLKLYEKRRSARXXXXXXXXXXXXXXXXLICKVRDGEY 1815
              +  +KKYDTP++ILEDF+  RL  YE+R++                   I +V +G  
Sbjct: 990  DANGVIKKYDTPEQILEDFFPLRLDYYERRKATLLRELGKISLTLENKVRFIKEVVEGT- 1048

Query: 1814 LVFPPKEKEERCAELMDKGFQS-------SQAIAYEVHPVE-RKATKEEELK-------- 1683
            LV   ++K +  AEL  K +           +IA  V  VE  + T+EEE          
Sbjct: 1049 LVVSNRKKADLYAELAKKKYTPLPKEAVIEASIAGAVDHVEGSEETEEEEASDVPIDVEA 1108

Query: 1682 -------TGYDYLLSTPIVSFSAEKIKELEKEMGAKKIELRELDNTSAKSLWLKDLDALI 1524
                   T YDYLLS  I S + EK+K+L KE   KK E  EL NT ++SLWLKDLD L 
Sbjct: 1109 AAAXIPGTEYDYLLSMAIASLTYEKMKQLWKERDEKKAEFDELTNTPSRSLWLKDLDDLD 1168

Query: 1523 RQLDAEKYPSAKRAPDAARPQ 1461
            +QLD +    AK   +  + Q
Sbjct: 1169 KQLDEQDKRDAKDEAERKKQQ 1189


>ref|XP_012455307.1| PREDICTED: DNA topoisomerase 2 isoform X2 [Gossypium raimondii]
 gb|KJB73929.1| hypothetical protein B456_011G261600 [Gossypium raimondii]
          Length = 1461

 Score =  188 bits (477), Expect = 1e-45
 Identities = 114/289 (39%), Positives = 163/289 (56%), Gaps = 13/289 (4%)
 Frame = -3

Query: 2333 MLPWYNGFKGEIEKTETPSKDTLYTTKGMIE-VDNNGITITELPVGTWTKVYEKSLKSRV 2157
            M PWY GFKG IEKT +      YT  G++E VD   + ITELP+  WT+ Y++ L+S +
Sbjct: 871  MHPWYRGFKGTIEKTASKESGVTYTISGIVEEVDETTLKITELPIRRWTQDYKEFLESVI 930

Query: 2156 -GND--IKAYTPRHGKTNNVHFEITMTNEQMKSAKEGGILNKFKLTTTLSTANMHMLGLD 1986
              ND  IK +  ++     VHFE+ MT E M  AK+ G++ KFKLTTT+ST+NMH+    
Sbjct: 931  TANDSFIKEFK-QYSDDRTVHFEVFMTEENMMLAKQEGLMKKFKLTTTVSTSNMHLFDSR 989

Query: 1985 DQLKKYDTPDEILEDFYHFRLKLYEKRRSARXXXXXXXXXXXXXXXXLICKVRDGEYLVF 1806
              +KKYDTP+EIL++FYH RL+ YEKRR                    I  V  G  +V 
Sbjct: 990  GMIKKYDTPEEILDEFYHLRLEFYEKRRKHMLDTLELELLKMDNKVRFILDVVKGNIIV- 1048

Query: 1805 PPKEKEERCAELMDKGF----QSSQAIAYEV-----HPVERKATKEEELKTGYDYLLSTP 1653
              +++ +   EL +KGF    + ++A+   V     H  E + + E    + YDYLLS  
Sbjct: 1049 NNRKRADLFLELQEKGFTPFPKKTKAVEVAVAGDIDHEGEPELSPEATRASDYDYLLSMA 1108

Query: 1652 IVSFSAEKIKELEKEMGAKKIELRELDNTSAKSLWLKDLDALIRQLDAE 1506
            I + + EK++EL  +    + E+ EL   + KSLWLKDL+ L +QLD +
Sbjct: 1109 IGTLTLEKVQELCSDRDKLEHEVEELRKHTPKSLWLKDLEELEKQLDEQ 1157


>ref|XP_012455306.1| PREDICTED: DNA topoisomerase 2 isoform X1 [Gossypium raimondii]
 gb|KJB73930.1| hypothetical protein B456_011G261600 [Gossypium raimondii]
          Length = 1462

 Score =  188 bits (477), Expect = 1e-45
 Identities = 114/289 (39%), Positives = 163/289 (56%), Gaps = 13/289 (4%)
 Frame = -3

Query: 2333 MLPWYNGFKGEIEKTETPSKDTLYTTKGMIE-VDNNGITITELPVGTWTKVYEKSLKSRV 2157
            M PWY GFKG IEKT +      YT  G++E VD   + ITELP+  WT+ Y++ L+S +
Sbjct: 871  MHPWYRGFKGTIEKTASKESGVTYTISGIVEEVDETTLKITELPIRRWTQDYKEFLESVI 930

Query: 2156 -GND--IKAYTPRHGKTNNVHFEITMTNEQMKSAKEGGILNKFKLTTTLSTANMHMLGLD 1986
              ND  IK +  ++     VHFE+ MT E M  AK+ G++ KFKLTTT+ST+NMH+    
Sbjct: 931  TANDSFIKEFK-QYSDDRTVHFEVFMTEENMMLAKQEGLMKKFKLTTTVSTSNMHLFDSR 989

Query: 1985 DQLKKYDTPDEILEDFYHFRLKLYEKRRSARXXXXXXXXXXXXXXXXLICKVRDGEYLVF 1806
              +KKYDTP+EIL++FYH RL+ YEKRR                    I  V  G  +V 
Sbjct: 990  GMIKKYDTPEEILDEFYHLRLEFYEKRRKHMLDTLELELLKMDNKVRFILDVVKGNIIV- 1048

Query: 1805 PPKEKEERCAELMDKGF----QSSQAIAYEV-----HPVERKATKEEELKTGYDYLLSTP 1653
              +++ +   EL +KGF    + ++A+   V     H  E + + E    + YDYLLS  
Sbjct: 1049 NNRKRADLFLELQEKGFTPFPKKTKAVEVAVAGDIDHEGEPELSPEATRASDYDYLLSMA 1108

Query: 1652 IVSFSAEKIKELEKEMGAKKIELRELDNTSAKSLWLKDLDALIRQLDAE 1506
            I + + EK++EL  +    + E+ EL   + KSLWLKDL+ L +QLD +
Sbjct: 1109 IGTLTLEKVQELCSDRDKLEHEVEELRKHTPKSLWLKDLEELEKQLDEQ 1157


>gb|KHG03878.1| DNA topoisomerase 2 -like protein [Gossypium arboreum]
          Length = 1245

 Score =  187 bits (475), Expect = 2e-45
 Identities = 114/289 (39%), Positives = 162/289 (56%), Gaps = 13/289 (4%)
 Frame = -3

Query: 2333 MLPWYNGFKGEIEKTETPSKDTLYTTKGMIE-VDNNGITITELPVGTWTKVYEKSLKSRV 2157
            M PWY GFKG IEKT +      YT  G++E VD   + ITELP+  WT+ Y++ L+S +
Sbjct: 871  MHPWYRGFKGTIEKTASKESGVTYTISGIVEEVDETTLKITELPIRRWTQDYKEFLESII 930

Query: 2156 -GND--IKAYTPRHGKTNNVHFEITMTNEQMKSAKEGGILNKFKLTTTLSTANMHMLGLD 1986
              ND  IK +  ++     VHFE+ MT E M  AK+ G++ KFKLTTT+ST+NMH+    
Sbjct: 931  TANDSFIKEFK-QYSDDRTVHFEVFMTEENMMLAKQEGLMKKFKLTTTVSTSNMHLFDSR 989

Query: 1985 DQLKKYDTPDEILEDFYHFRLKLYEKRRSARXXXXXXXXXXXXXXXXLICKVRDGEYLVF 1806
              +KKYDTP+EIL++FYH RL+ YEKRR                    I  V  G  +V 
Sbjct: 990  GMIKKYDTPEEILDEFYHLRLEFYEKRRKHMLDTLELELLKMDNKVRFILDVVKGNIIV- 1048

Query: 1805 PPKEKEERCAELMDKGFQS--------SQAIAYEV-HPVERKATKEEELKTGYDYLLSTP 1653
              +++ +   EL +KGF            A+A ++ H  E + + E    + YDYLLS  
Sbjct: 1049 NNRKRADLFLELQEKGFTPFPKKTKGVEVAVAGDIDHEGEPELSPEATRASDYDYLLSMA 1108

Query: 1652 IVSFSAEKIKELEKEMGAKKIELRELDNTSAKSLWLKDLDALIRQLDAE 1506
            I + + EK++EL  +    + E+ EL   + KSLWLKDL+ L +QLD +
Sbjct: 1109 IGTLTLEKVQELCSDRDKLEHEVEELRKHTPKSLWLKDLEELEKQLDEQ 1157


>gb|PPD78478.1| hypothetical protein GOBAR_DD24581 [Gossypium barbadense]
          Length = 1420

 Score =  187 bits (475), Expect = 2e-45
 Identities = 114/289 (39%), Positives = 163/289 (56%), Gaps = 13/289 (4%)
 Frame = -3

Query: 2333 MLPWYNGFKGEIEKTETPSKDTLYTTKGMIE-VDNNGITITELPVGTWTKVYEKSLKSRV 2157
            M PWY GFKG IEKT +      YT  G++E VD   + ITELP+  WT+ Y++ L+S +
Sbjct: 847  MHPWYRGFKGTIEKTASKESGVTYTISGIVEEVDETTLKITELPLRRWTQDYKEFLESVI 906

Query: 2156 -GND--IKAYTPRHGKTNNVHFEITMTNEQMKSAKEGGILNKFKLTTTLSTANMHMLGLD 1986
              ND  IK +  ++     VHFE+ MT E M  AK+ G++ KFKLTTT+ST+NMH+    
Sbjct: 907  TANDSFIKEFK-QYSDDRTVHFEVFMTEENMMLAKQEGLMKKFKLTTTVSTSNMHLFDSR 965

Query: 1985 DQLKKYDTPDEILEDFYHFRLKLYEKRRSARXXXXXXXXXXXXXXXXLICKVRDGEYLVF 1806
              +KKYDTP+EIL++FYH RL+ YEKRR                    I  V  G  +V 
Sbjct: 966  GMIKKYDTPEEILDEFYHLRLEFYEKRRKHMLDTLELELLKMDNKVRFILDVVKGNIIV- 1024

Query: 1805 PPKEKEERCAELMDKGF----QSSQAIAYEV-----HPVERKATKEEELKTGYDYLLSTP 1653
              +++ +   EL +KGF    + ++A+   V     H  E + + E    + YDYLLS  
Sbjct: 1025 NNRKRADLFLELQEKGFTPFPKKTKAVEVAVAGDIDHEGEPELSPEATRASDYDYLLSMA 1084

Query: 1652 IVSFSAEKIKELEKEMGAKKIELRELDNTSAKSLWLKDLDALIRQLDAE 1506
            I + + EK++EL  +    + E+ EL   + KSLWLKDL+ L +QLD +
Sbjct: 1085 IGTLTLEKVQELCSDRDKLEHEVEELRKHTPKSLWLKDLEELEKQLDEQ 1133


>ref|XP_017619617.1| PREDICTED: DNA topoisomerase 2 isoform X2 [Gossypium arboreum]
          Length = 1459

 Score =  187 bits (475), Expect = 2e-45
 Identities = 114/289 (39%), Positives = 162/289 (56%), Gaps = 13/289 (4%)
 Frame = -3

Query: 2333 MLPWYNGFKGEIEKTETPSKDTLYTTKGMIE-VDNNGITITELPVGTWTKVYEKSLKSRV 2157
            M PWY GFKG IEKT +      YT  G++E VD   + ITELP+  WT+ Y++ L+S +
Sbjct: 871  MHPWYRGFKGTIEKTASKESGVTYTISGIVEEVDETTLKITELPIRRWTQDYKEFLESII 930

Query: 2156 -GND--IKAYTPRHGKTNNVHFEITMTNEQMKSAKEGGILNKFKLTTTLSTANMHMLGLD 1986
              ND  IK +  ++     VHFE+ MT E M  AK+ G++ KFKLTTT+ST+NMH+    
Sbjct: 931  TANDSFIKEFK-QYSDDRTVHFEVFMTEENMMLAKQEGLMKKFKLTTTVSTSNMHLFDSR 989

Query: 1985 DQLKKYDTPDEILEDFYHFRLKLYEKRRSARXXXXXXXXXXXXXXXXLICKVRDGEYLVF 1806
              +KKYDTP+EIL++FYH RL+ YEKRR                    I  V  G  +V 
Sbjct: 990  GMIKKYDTPEEILDEFYHLRLEFYEKRRKHMLDTLELELLKMDNKVRFILDVVKGNIIV- 1048

Query: 1805 PPKEKEERCAELMDKGFQS--------SQAIAYEV-HPVERKATKEEELKTGYDYLLSTP 1653
              +++ +   EL +KGF            A+A ++ H  E + + E    + YDYLLS  
Sbjct: 1049 NNRKRADLFLELQEKGFTPFPKKTKGVEVAVAGDIDHEGEPELSPEATRASDYDYLLSMA 1108

Query: 1652 IVSFSAEKIKELEKEMGAKKIELRELDNTSAKSLWLKDLDALIRQLDAE 1506
            I + + EK++EL  +    + E+ EL   + KSLWLKDL+ L +QLD +
Sbjct: 1109 IGTLTLEKVQELCSDRDKLEHEVEELRKHTPKSLWLKDLEELEKQLDEQ 1157


>ref|XP_017619616.1| PREDICTED: DNA topoisomerase 2 isoform X1 [Gossypium arboreum]
          Length = 1460

 Score =  187 bits (475), Expect = 2e-45
 Identities = 114/289 (39%), Positives = 162/289 (56%), Gaps = 13/289 (4%)
 Frame = -3

Query: 2333 MLPWYNGFKGEIEKTETPSKDTLYTTKGMIE-VDNNGITITELPVGTWTKVYEKSLKSRV 2157
            M PWY GFKG IEKT +      YT  G++E VD   + ITELP+  WT+ Y++ L+S +
Sbjct: 871  MHPWYRGFKGTIEKTASKESGVTYTISGIVEEVDETTLKITELPIRRWTQDYKEFLESII 930

Query: 2156 -GND--IKAYTPRHGKTNNVHFEITMTNEQMKSAKEGGILNKFKLTTTLSTANMHMLGLD 1986
              ND  IK +  ++     VHFE+ MT E M  AK+ G++ KFKLTTT+ST+NMH+    
Sbjct: 931  TANDSFIKEFK-QYSDDRTVHFEVFMTEENMMLAKQEGLMKKFKLTTTVSTSNMHLFDSR 989

Query: 1985 DQLKKYDTPDEILEDFYHFRLKLYEKRRSARXXXXXXXXXXXXXXXXLICKVRDGEYLVF 1806
              +KKYDTP+EIL++FYH RL+ YEKRR                    I  V  G  +V 
Sbjct: 990  GMIKKYDTPEEILDEFYHLRLEFYEKRRKHMLDTLELELLKMDNKVRFILDVVKGNIIV- 1048

Query: 1805 PPKEKEERCAELMDKGFQS--------SQAIAYEV-HPVERKATKEEELKTGYDYLLSTP 1653
              +++ +   EL +KGF            A+A ++ H  E + + E    + YDYLLS  
Sbjct: 1049 NNRKRADLFLELQEKGFTPFPKKTKGVEVAVAGDIDHEGEPELSPEATRASDYDYLLSMA 1108

Query: 1652 IVSFSAEKIKELEKEMGAKKIELRELDNTSAKSLWLKDLDALIRQLDAE 1506
            I + + EK++EL  +    + E+ EL   + KSLWLKDL+ L +QLD +
Sbjct: 1109 IGTLTLEKVQELCSDRDKLEHEVEELRKHTPKSLWLKDLEELEKQLDEQ 1157


>ref|XP_016722313.1| PREDICTED: DNA topoisomerase 2 isoform X2 [Gossypium hirsutum]
          Length = 1461

 Score =  187 bits (475), Expect = 2e-45
 Identities = 114/289 (39%), Positives = 163/289 (56%), Gaps = 13/289 (4%)
 Frame = -3

Query: 2333 MLPWYNGFKGEIEKTETPSKDTLYTTKGMIE-VDNNGITITELPVGTWTKVYEKSLKSRV 2157
            M PWY GFKG IEKT +      YT  G++E VD   + ITELP+  WT+ Y++ L+S +
Sbjct: 871  MHPWYRGFKGTIEKTASKESGVTYTISGIVEEVDETTLKITELPLRRWTQDYKEFLESVI 930

Query: 2156 -GND--IKAYTPRHGKTNNVHFEITMTNEQMKSAKEGGILNKFKLTTTLSTANMHMLGLD 1986
              ND  IK +  ++     VHFE+ MT E M  AK+ G++ KFKLTTT+ST+NMH+    
Sbjct: 931  TANDSFIKEFK-QYSDDRTVHFEVFMTEENMMLAKQEGLMKKFKLTTTVSTSNMHLFDSR 989

Query: 1985 DQLKKYDTPDEILEDFYHFRLKLYEKRRSARXXXXXXXXXXXXXXXXLICKVRDGEYLVF 1806
              +KKYDTP+EIL++FYH RL+ YEKRR                    I  V  G  +V 
Sbjct: 990  GMIKKYDTPEEILDEFYHLRLEFYEKRRKHMLDTLELELLKMDNKVRFILDVVKGNIIV- 1048

Query: 1805 PPKEKEERCAELMDKGF----QSSQAIAYEV-----HPVERKATKEEELKTGYDYLLSTP 1653
              +++ +   EL +KGF    + ++A+   V     H  E + + E    + YDYLLS  
Sbjct: 1049 NNRKRADLFLELQEKGFTPFPKKTKAVEVAVAGDIDHEGEPELSPEATRASDYDYLLSMA 1108

Query: 1652 IVSFSAEKIKELEKEMGAKKIELRELDNTSAKSLWLKDLDALIRQLDAE 1506
            I + + EK++EL  +    + E+ EL   + KSLWLKDL+ L +QLD +
Sbjct: 1109 IGTLTLEKVQELCSDRDKLEHEVEELRKHTPKSLWLKDLEELEKQLDEQ 1157


>ref|XP_016722312.1| PREDICTED: DNA topoisomerase 2 isoform X1 [Gossypium hirsutum]
          Length = 1462

 Score =  187 bits (475), Expect = 2e-45
 Identities = 114/289 (39%), Positives = 163/289 (56%), Gaps = 13/289 (4%)
 Frame = -3

Query: 2333 MLPWYNGFKGEIEKTETPSKDTLYTTKGMIE-VDNNGITITELPVGTWTKVYEKSLKSRV 2157
            M PWY GFKG IEKT +      YT  G++E VD   + ITELP+  WT+ Y++ L+S +
Sbjct: 871  MHPWYRGFKGTIEKTASKESGVTYTISGIVEEVDETTLKITELPLRRWTQDYKEFLESVI 930

Query: 2156 -GND--IKAYTPRHGKTNNVHFEITMTNEQMKSAKEGGILNKFKLTTTLSTANMHMLGLD 1986
              ND  IK +  ++     VHFE+ MT E M  AK+ G++ KFKLTTT+ST+NMH+    
Sbjct: 931  TANDSFIKEFK-QYSDDRTVHFEVFMTEENMMLAKQEGLMKKFKLTTTVSTSNMHLFDSR 989

Query: 1985 DQLKKYDTPDEILEDFYHFRLKLYEKRRSARXXXXXXXXXXXXXXXXLICKVRDGEYLVF 1806
              +KKYDTP+EIL++FYH RL+ YEKRR                    I  V  G  +V 
Sbjct: 990  GMIKKYDTPEEILDEFYHLRLEFYEKRRKHMLDTLELELLKMDNKVRFILDVVKGNIIV- 1048

Query: 1805 PPKEKEERCAELMDKGF----QSSQAIAYEV-----HPVERKATKEEELKTGYDYLLSTP 1653
              +++ +   EL +KGF    + ++A+   V     H  E + + E    + YDYLLS  
Sbjct: 1049 NNRKRADLFLELQEKGFTPFPKKTKAVEVAVAGDIDHEGEPELSPEATRASDYDYLLSMA 1108

Query: 1652 IVSFSAEKIKELEKEMGAKKIELRELDNTSAKSLWLKDLDALIRQLDAE 1506
            I + + EK++EL  +    + E+ EL   + KSLWLKDL+ L +QLD +
Sbjct: 1109 IGTLTLEKVQELCSDRDKLEHEVEELRKHTPKSLWLKDLEELEKQLDEQ 1157


>ref|XP_018621925.1| PREDICTED: DNA topoisomerase 2 isoform X2 [Nicotiana tomentosiformis]
          Length = 1481

 Score =  187 bits (475), Expect = 2e-45
 Identities = 116/292 (39%), Positives = 163/292 (55%), Gaps = 16/292 (5%)
 Frame = -3

Query: 2333 MLPWYNGFKGEIEKTETPSKDTLYTTKGMIE-VDNNGITITELPVGTWTKVYEKSLKSRV 2157
            M PWY GFKG IEKT T      YT  G+IE V+   + I+ELPV  WT+ Y++ L+S  
Sbjct: 867  MDPWYKGFKGTIEKTATKEAGATYTVTGIIEEVNETTLRISELPVRRWTEDYKQFLESMT 926

Query: 2156 GNDIKAYTP------RHGKTNNVHFEITMTNEQMKSAKEGGILNKFKLTTTLSTANMHML 1995
             ++ KA  P       +G  N+V FE+ M+ E +  A++ G+L KFKL TT+ST+NMH+ 
Sbjct: 927  VSNDKAKDPFIKEVRAYGDENSVCFEVIMSEENLILAQQEGLLKKFKLATTISTSNMHLF 986

Query: 1994 GLDDQLKKYDTPDEILEDFYHFRLKLYEKRRSARXXXXXXXXXXXXXXXXLICKVRDGEY 1815
              + ++KKYD P++ILE+FYH RL+ YEKR+ A                  I  V  GE 
Sbjct: 987  DSNGKIKKYDNPEDILEEFYHVRLEYYEKRKKALLEILELELLRIENKVKFILGVVKGEI 1046

Query: 1814 LVFPPKEKEERCAELMDKG---FQSSQAIAYEVHPVERKA-TKEEELKTG-----YDYLL 1662
            +V   +++ +   EL +KG   F   +A+   V      A   EEEL  G     YDYLL
Sbjct: 1047 IV-NNRKRADLLLELKEKGFTPFPKKKAVEAVVADTSDDAEDSEEELNRGVRAGDYDYLL 1105

Query: 1661 STPIVSFSAEKIKELEKEMGAKKIELRELDNTSAKSLWLKDLDALIRQLDAE 1506
            S PI + + EK++EL  E      E+ ++ N + K LWLKDLD L +QLD +
Sbjct: 1106 SMPIGTLTLEKVQELCAERDKLNGEVEDMRNATPKLLWLKDLDVLEKQLDEQ 1157


>ref|XP_018621924.1| PREDICTED: DNA topoisomerase 2 isoform X1 [Nicotiana tomentosiformis]
          Length = 1482

 Score =  187 bits (475), Expect = 2e-45
 Identities = 116/292 (39%), Positives = 163/292 (55%), Gaps = 16/292 (5%)
 Frame = -3

Query: 2333 MLPWYNGFKGEIEKTETPSKDTLYTTKGMIE-VDNNGITITELPVGTWTKVYEKSLKSRV 2157
            M PWY GFKG IEKT T      YT  G+IE V+   + I+ELPV  WT+ Y++ L+S  
Sbjct: 867  MDPWYKGFKGTIEKTATKEAGATYTVTGIIEEVNETTLRISELPVRRWTEDYKQFLESMT 926

Query: 2156 GNDIKAYTP------RHGKTNNVHFEITMTNEQMKSAKEGGILNKFKLTTTLSTANMHML 1995
             ++ KA  P       +G  N+V FE+ M+ E +  A++ G+L KFKL TT+ST+NMH+ 
Sbjct: 927  VSNDKAKDPFIKEVRAYGDENSVCFEVIMSEENLILAQQEGLLKKFKLATTISTSNMHLF 986

Query: 1994 GLDDQLKKYDTPDEILEDFYHFRLKLYEKRRSARXXXXXXXXXXXXXXXXLICKVRDGEY 1815
              + ++KKYD P++ILE+FYH RL+ YEKR+ A                  I  V  GE 
Sbjct: 987  DSNGKIKKYDNPEDILEEFYHVRLEYYEKRKKALLEILELELLRIENKVKFILGVVKGEI 1046

Query: 1814 LVFPPKEKEERCAELMDKG---FQSSQAIAYEVHPVERKA-TKEEELKTG-----YDYLL 1662
            +V   +++ +   EL +KG   F   +A+   V      A   EEEL  G     YDYLL
Sbjct: 1047 IV-NNRKRADLLLELKEKGFTPFPKKKAVEAVVADTSDDAEDSEEELNRGVRAGDYDYLL 1105

Query: 1661 STPIVSFSAEKIKELEKEMGAKKIELRELDNTSAKSLWLKDLDALIRQLDAE 1506
            S PI + + EK++EL  E      E+ ++ N + K LWLKDLD L +QLD +
Sbjct: 1106 SMPIGTLTLEKVQELCAERDKLNGEVEDMRNATPKLLWLKDLDVLEKQLDEQ 1157