BLASTX nr result
ID: Cheilocostus21_contig00066459
seq
BLASTX 2.2.26 [Sep-21-2011]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Cheilocostus21_contig00066459
(505 letters)
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects
149,584,005 sequences; 54,822,741,787 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
emb|CUG86908.1| cysteine peptidase, putative, partial [Bodo salt... 180 6e-53
emb|CUE71938.1| cysteine peptidase, putative [Bodo saltans] 182 6e-52
emb|CUG86907.1| cysteine peptidase, putative [Bodo saltans] 180 5e-51
emb|CUE71934.1| cysteine peptidase, putative, partial [Bodo salt... 160 2e-45
gb|ESL05360.1| cysteine peptidase [Trypanosoma rangeli SC58] 159 3e-45
pdb|1EWP|A Chain A, Cruzain Bound To Mor-Leu-Hpq >gi|9955113|pdb... 155 9e-45
pdb|4W5B|A Chain A, Crystal structure analysis of cruzain with F... 155 9e-45
pdb|4W5C|A Chain A, Crystal structure analysis of cruzain with t... 155 9e-45
pdb|4XUI|A Chain A, Crystal Structure Analysis Of Cruzain Bound ... 155 9e-45
gb|EKF26779.1| cysteine peptidase, partial [Trypanosoma cruzi ma... 154 1e-44
gb|ABQ23400.1| cathepsin L isotype 3 [Trypanoplasma borreli] 161 1e-44
ref|XP_804236.1| cruzipain precursor [Trypanosoma cruzi strain C... 156 2e-44
gb|EKF98349.1| cysteine peptidase, putative,cysteine peptidase, ... 155 2e-44
pdb|3HD3|A Chain A, High Resolution Crystal Structure Of Cruzain... 154 2e-44
ref|XP_009316281.1| cathepsin L-like protein [Trypanosoma grayi]... 156 3e-44
pdb|3IUT|A Chain A, The Crystal Structure of Cruzain in Complex ... 154 3e-44
gb|EKF27621.1| cysteine peptidase, putative, partial [Trypanosom... 154 3e-44
gb|ACI00341.1| cysteine proteinase, partial [Trypanosoma cruzi] 157 4e-44
emb|CUG31439.1| cathepsin-L cysteine peptidase, putative, partia... 157 5e-44
gb|ACR07923.1| cysteine proteinase, partial [Trypanosoma cruzi] 157 5e-44
>emb|CUG86908.1| cysteine peptidase, putative, partial [Bodo saltans]
Length = 340
Score = 180 bits (457), Expect = 6e-53
Identities = 86/137 (62%), Positives = 101/137 (73%)
Frame = -3
Query: 500 GQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIGV 321
G+IVTE SYPYV + V +TI+GHVD+ E M AW +NGP+S+ V
Sbjct: 193 GKIVTEASYPYVSGGGNVPACSLSGTT-VGSTINGHVDVATNEAAMGAWVYANGPMSVAV 251
Query: 320 DATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGYG 141
DATSWQ+Y GGILTNC+S Q+DHGVL+VGFD T+STPYWIIKNSW ASWGE GYIRV G
Sbjct: 252 DATSWQSYTGGILTNCISSQIDHGVLVVGFDDTFSTPYWIIKNSWAASWGEEGYIRVQKG 311
Query: 140 SDQCLITSGPCSSTVNK 90
+DQCLIT+ PCSS V K
Sbjct: 312 TDQCLITTVPCSSKVAK 328
>emb|CUE71938.1| cysteine peptidase, putative [Bodo saltans]
Length = 535
Score = 182 bits (463), Expect = 6e-52
Identities = 89/135 (65%), Positives = 99/135 (73%)
Frame = -3
Query: 500 GQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIGV 321
G IVTE SYPYV + ATI+GH DLPQ E QMA W ++NGP+SIGV
Sbjct: 275 GAIVTEASYPYVSGTGTVPACALPKTK--GATINGHEDLPQNEAQMATWMSTNGPISIGV 332
Query: 320 DATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGYG 141
DATSWQTY GI+TNC+S QVDHGVL VGFD T S PYWIIKNSWGA+WGE+GYIRV G
Sbjct: 333 DATSWQTYTSGIMTNCISSQVDHGVLAVGFDDTNSPPYWIIKNSWGATWGESGYIRVQKG 392
Query: 140 SDQCLITSGPCSSTV 96
+DQCLITS CSS V
Sbjct: 393 TDQCLITSNACSSKV 407
>emb|CUG86907.1| cysteine peptidase, putative [Bodo saltans]
Length = 549
Score = 180 bits (457), Expect = 5e-51
Identities = 86/137 (62%), Positives = 101/137 (73%)
Frame = -3
Query: 500 GQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIGV 321
G+IVTE SYPYV + V +TI+GHVD+ E M AW +NGP+S+ V
Sbjct: 193 GKIVTEASYPYVSGGGNVPACSLSGTT-VGSTINGHVDVATNEAAMGAWVYANGPMSVAV 251
Query: 320 DATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGYG 141
DATSWQ+Y GGILTNC+S Q+DHGVL+VGFD T+STPYWIIKNSW ASWGE GYIRV G
Sbjct: 252 DATSWQSYTGGILTNCISSQIDHGVLVVGFDDTFSTPYWIIKNSWAASWGEEGYIRVQKG 311
Query: 140 SDQCLITSGPCSSTVNK 90
+DQCLIT+ PCSS V K
Sbjct: 312 TDQCLITTVPCSSKVAK 328
>emb|CUE71934.1| cysteine peptidase, putative, partial [Bodo saltans]
Length = 303
Score = 160 bits (405), Expect = 2e-45
Identities = 76/136 (55%), Positives = 95/136 (69%)
Frame = -3
Query: 503 NGQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIG 324
NG I TE SYP+V + ATI+GH+DLPQ E QMA W ++ GP+SI
Sbjct: 124 NGNIATEASYPFVSGSGTAPACALPKT--TGATITGHIDLPQNEDQMATWLSTKGPISIA 181
Query: 323 VDATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGY 144
VDATS+QTY+GGILTN +S+Q+DH +L VG++ STP WI+KNSWG SWGE+GYI +
Sbjct: 182 VDATSFQTYVGGILTNSISKQLDHAILAVGYNDVASTPNWIVKNSWGTSWGEDGYIYIAK 241
Query: 143 GSDQCLITSGPCSSTV 96
GS+QCLI S P SS V
Sbjct: 242 GSNQCLIDSAPSSSVV 257
>gb|ESL05360.1| cysteine peptidase [Trypanosoma rangeli SC58]
Length = 293
Score = 159 bits (402), Expect = 3e-45
Identities = 75/136 (55%), Positives = 95/136 (69%)
Frame = -3
Query: 503 NGQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIG 324
NG + TE SY YV + V A ISGHVDLPQ E +MAAW NGP++I
Sbjct: 29 NGSVYTEASYSYVSGGGDSQTCSMSSHV-VGAVISGHVDLPQDEDKMAAWLAVNGPLAIA 87
Query: 323 VDATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGY 144
VDATS+ +Y GG+LTNCVS Q+DHGV++VG++ + + PYWIIKNSWGA WGE GYIR+
Sbjct: 88 VDATSFMSYTGGVLTNCVSDQLDHGVVLVGYNDSSNPPYWIIKNSWGADWGEEGYIRIQK 147
Query: 143 GSDQCLITSGPCSSTV 96
G++QCL+ S CS+ V
Sbjct: 148 GTNQCLVNSYACSAVV 163
>pdb|1EWP|A Chain A, Cruzain Bound To Mor-Leu-Hpq
pdb|1F29|A Chain A, Crystal Structure Analysis Of Cruzain Bound To A Vinyl
Sulfone Derived Inhibitor (I)
pdb|1F29|B Chain B, Crystal Structure Analysis Of Cruzain Bound To A Vinyl
Sulfone Derived Inhibitor (I)
pdb|1F29|C Chain C, Crystal Structure Analysis Of Cruzain Bound To A Vinyl
Sulfone Derived Inhibitor (I)
pdb|1F2A|A Chain A, Crystal Structure Analysis Of Cruzain Bound To A Vinyl
Sulfone Derived Inhibitor (Ii)
pdb|1F2B|A Chain A, Crystal Structure Analysis Of Cruzain Bound To Vinyl
Sulfone Derived Inhibitor (Iii)
pdb|1F2C|A Chain A, Crystal Structure Analysis Of Cryzain Bound To Vinyl
Sulfone Derived Inhibitor (Iv)
pdb|1ME3|A Chain A, High Resolution Crystal Structure Analysis Of Cruzain
Non-covalently Bound To A Hydroxymethyl Ketone Inhibitor
(ii)
pdb|1ME4|A Chain A, High Resolution Crystal Structure Analysis Of Cruzain
Non-covalently Bound To A Hydroxymethyl Ketone Inhibitor
(i)
pdb|1EWL|A Chain A, Crystal Structure Of Cruzain Bound To Wrr-99
pdb|1EWM|A Chain A, The Cysteine Protease Cruzain Bound To Wrr-112
pdb|1EWO|A Chain A, The Cysteine Protease Cruzain Bound To Wrr-204
pdb|1U9Q|X Chain X, Crystal Structure Of Cruzain Bound To An Alpha-ketoester
pdb|2AIM|A Chain A, Cruzain Inhibited With
Benzoyl-Arginine-Alanine-Fluoromethylketone
pdb|2OZ2|A Chain A, Crystal Structure Analysis Of Cruzain Bound To Vinyl
Sulfone Derived Inhibitor (K11777)
pdb|2OZ2|C Chain C, Crystal Structure Analysis Of Cruzain Bound To Vinyl
Sulfone Derived Inhibitor (K11777)
pdb|3I06|A Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine
Nitrile
pdb|3KKU|A Chain A, Cruzain In Complex With A Non-Covalent Ligand
pdb|3LXS|A Chain A, Crystal structure analysis of cruzain bound to vinyl
sulfone derived inhibitor (WRR483)
pdb|3LXS|C Chain C, Crystal structure analysis of cruzain bound to vinyl
sulfone derived inhibitor (WRR483)
pdb|4KLB|A Chain A, Crystal Structure of Cruzain in complex with the
non-covalent inhibitor Nequimed176
pdb|4KLB|B Chain B, Crystal Structure of Cruzain in complex with the
non-covalent inhibitor Nequimed176
pdb|4KLB|C Chain C, Crystal Structure of Cruzain in complex with the
non-covalent inhibitor Nequimed176
pdb|4KLB|D Chain D, Crystal Structure of Cruzain in complex with the
non-covalent inhibitor Nequimed176
pdb|4KLB|E Chain E, Crystal Structure of Cruzain in complex with the
non-covalent inhibitor Nequimed176
pdb|4QH6|A Chain A, Crystal structure of cruzain with nitrile inhibitor
N-(2-AMINOETHYL)-NALPHA-BENZOYL-L-PHENYLALANINAMIDE
pdb|4QH6|B Chain B, Crystal structure of cruzain with nitrile inhibitor
N-(2-AMINOETHYL)-NALPHA-BENZOYL-L-PHENYLALANINAMIDE
pdb|4QH6|C Chain C, Crystal structure of cruzain with nitrile inhibitor
N-(2-AMINOETHYL)-NALPHA-BENZOYL-L-PHENYLALANINAMIDE
pdb|4QH6|D Chain D, Crystal structure of cruzain with nitrile inhibitor
N-(2-AMINOETHYL)-NALPHA-BENZOYL-L-PHENYLALANINAMIDE
pdb|4QH6|E Chain E, Crystal structure of cruzain with nitrile inhibitor
N-(2-AMINOETHYL)-NALPHA-BENZOYL-L-PHENYLALANINAMIDE
Length = 215
Score = 155 bits (393), Expect = 9e-45
Identities = 71/136 (52%), Positives = 93/136 (68%)
Frame = -3
Query: 503 NGQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIG 324
NG + TE+SYPY V ATI+GHV+LPQ E Q+AAW NGPV++
Sbjct: 80 NGAVYTEDSYPYASGEGISPPCTTSGHT-VGATITGHVELPQDEAQIAAWLAVNGPVAVA 138
Query: 323 VDATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGY 144
VDA+SW TY GG++T+CVS+Q+DHGVL+VG++ + + PYWIIKNSW WGE GYIR+
Sbjct: 139 VDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAK 198
Query: 143 GSDQCLITSGPCSSTV 96
GS+QCL+ S+ V
Sbjct: 199 GSNQCLVKEEASSAVV 214
>pdb|4W5B|A Chain A, Crystal structure analysis of cruzain with Fragment 1
(N-(1H-benzimidazol-2-yl)-1,
3-dimethyl-pyrazole-4-carboxamide)
pdb|4W5B|B Chain B, Crystal structure analysis of cruzain with Fragment 1
(N-(1H-benzimidazol-2-yl)-1,
3-dimethyl-pyrazole-4-carboxamide)
pdb|4W5B|C Chain C, Crystal structure analysis of cruzain with Fragment 1
(N-(1H-benzimidazol-2-yl)-1,
3-dimethyl-pyrazole-4-carboxamide)
Length = 215
Score = 155 bits (393), Expect = 9e-45
Identities = 71/136 (52%), Positives = 93/136 (68%)
Frame = -3
Query: 503 NGQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIG 324
NG + TE+SYPY V ATI+GHV+LPQ E Q+AAW NGPV++
Sbjct: 80 NGAVYTEDSYPYASGEGISPPCTTSGHT-VGATITGHVELPQDEAQIAAWLAVNGPVAVA 138
Query: 323 VDATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGY 144
VDA+SW TY GG++T+CVS+Q+DHGVL+VG++ + + PYWIIKNSW WGE GYIR+
Sbjct: 139 VDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAK 198
Query: 143 GSDQCLITSGPCSSTV 96
GS+QCL+ S+ V
Sbjct: 199 GSNQCLVKEEASSAVV 214
>pdb|4W5C|A Chain A, Crystal structure analysis of cruzain with three
Fragments: 1
(N-(1H-benzimidazol-2-yl)-1,
3-dimethyl-pyrazole-4-carboxamide), 6
(2-amino-4,6-difluorobenzothiazole) and 9
(N-(1H-benzimidazol-2-yl)-3-(4-fluorophenyl)-1H-
pyrazole-4-carboxamide).
pdb|4W5C|B Chain B, Crystal structure analysis of cruzain with three
Fragments: 1
(N-(1H-benzimidazol-2-yl)-1,
3-dimethyl-pyrazole-4-carboxamide), 6
(2-amino-4,6-difluorobenzothiazole) and 9
(N-(1H-benzimidazol-2-yl)-3-(4-fluorophenyl)-1H-
pyrazole-4-carboxamide).
pdb|4W5C|C Chain C, Crystal structure analysis of cruzain with three
Fragments: 1
(N-(1H-benzimidazol-2-yl)-1,
3-dimethyl-pyrazole-4-carboxamide), 6
(2-amino-4,6-difluorobenzothiazole) and 9
(N-(1H-benzimidazol-2-yl)-3-(4-fluorophenyl)-1H-
pyrazole-4-carboxamide).
pdb|4W5C|D Chain D, Crystal structure analysis of cruzain with three
Fragments: 1
(N-(1H-benzimidazol-2-yl)-1,
3-dimethyl-pyrazole-4-carboxamide), 6
(2-amino-4,6-difluorobenzothiazole) and 9
(N-(1H-benzimidazol-2-yl)-3-(4-fluorophenyl)-1H-
pyrazole-4-carboxamide).
pdb|4W5C|E Chain E, Crystal structure analysis of cruzain with three
Fragments: 1
(N-(1H-benzimidazol-2-yl)-1,
3-dimethyl-pyrazole-4-carboxamide), 6
(2-amino-4,6-difluorobenzothiazole) and 9
(N-(1H-benzimidazol-2-yl)-3-(4-fluorophenyl)-1H-
pyrazole-4-carboxamide).
Length = 216
Score = 155 bits (393), Expect = 9e-45
Identities = 71/136 (52%), Positives = 93/136 (68%)
Frame = -3
Query: 503 NGQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIG 324
NG + TE+SYPY V ATI+GHV+LPQ E Q+AAW NGPV++
Sbjct: 81 NGAVYTEDSYPYASGEGISPPCTTSGHT-VGATITGHVELPQDEAQIAAWLAVNGPVAVA 139
Query: 323 VDATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGY 144
VDA+SW TY GG++T+CVS+Q+DHGVL+VG++ + + PYWIIKNSW WGE GYIR+
Sbjct: 140 VDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAK 199
Query: 143 GSDQCLITSGPCSSTV 96
GS+QCL+ S+ V
Sbjct: 200 GSNQCLVKEEASSAVV 215
>pdb|4XUI|A Chain A, Crystal Structure Analysis Of Cruzain Bound To The
No-covalent Analog Of Wrr-483 (wrr-669)
pdb|4XUI|B Chain B, Crystal Structure Analysis Of Cruzain Bound To The
No-covalent Analog Of Wrr-483 (wrr-669)
pdb|4XUI|C Chain C, Crystal Structure Analysis Of Cruzain Bound To The
No-covalent Analog Of Wrr-483 (wrr-669)
pdb|4PI3|A Chain A, Crystal Structure Analysis Of Cruzain Bound To Vinyl
Sulfone Analog Of Wrr-483 (wrr-666)
pdb|4PI3|B Chain B, Crystal Structure Analysis Of Cruzain Bound To Vinyl
Sulfone Analog Of Wrr-483 (wrr-666)
Length = 216
Score = 155 bits (393), Expect = 9e-45
Identities = 71/136 (52%), Positives = 93/136 (68%)
Frame = -3
Query: 503 NGQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIG 324
NG + TE+SYPY V ATI+GHV+LPQ E Q+AAW NGPV++
Sbjct: 81 NGAVYTEDSYPYASGEGISPPCTTSGHT-VGATITGHVELPQDEAQIAAWLAVNGPVAVA 139
Query: 323 VDATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGY 144
VDA+SW TY GG++T+CVS+Q+DHGVL+VG++ + + PYWIIKNSW WGE GYIR+
Sbjct: 140 VDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAK 199
Query: 143 GSDQCLITSGPCSSTV 96
GS+QCL+ S+ V
Sbjct: 200 GSNQCLVKEEASSAVV 215
>gb|EKF26779.1| cysteine peptidase, partial [Trypanosoma cruzi marinkellei]
Length = 179
Score = 154 bits (389), Expect = 1e-44
Identities = 71/136 (52%), Positives = 91/136 (66%)
Frame = -3
Query: 503 NGQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIG 324
NG + TE SYPY V A I+GHV+LPQ E Q+AAW +NGPV++
Sbjct: 29 NGAVYTEESYPYASGEGISPPCTTSGHT-VGAMITGHVELPQDEAQIAAWLAANGPVAVA 87
Query: 323 VDATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGY 144
VDATSW TY GG++T+CVS+Q+DHGVL+VG++ + PYWIIKNSW WGE GYIR+
Sbjct: 88 VDATSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAPVPYWIIKNSWTTLWGEEGYIRIAK 147
Query: 143 GSDQCLITSGPCSSTV 96
GS+QCL+ S+ V
Sbjct: 148 GSNQCLVKEEASSAVV 163
>gb|ABQ23400.1| cathepsin L isotype 3 [Trypanoplasma borreli]
Length = 442
Score = 161 bits (408), Expect = 1e-44
Identities = 81/137 (59%), Positives = 97/137 (70%), Gaps = 1/137 (0%)
Frame = -3
Query: 503 NGQIVTENSYPYVXXXXXXXXXXXXXSM-PVAATISGHVDLPQTEQQMAAWCNSNGPVSI 327
NGQI TE SYPYV + PV ATI+ D+P+TE+ MAA+ GP+SI
Sbjct: 193 NGQITTEASYPYVSGNGIVPACTFNSNSNPVGATITSFHDIPKTERDMAAFVFKYGPLSI 252
Query: 326 GVDATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVG 147
GVDA+SWQ+Y+GGIL++C Q+DHGVLIVGFD T STPYWIIKNSW + WGE GYIRV
Sbjct: 253 GVDASSWQSYIGGILSHCSDVQIDHGVLIVGFDDTASTPYWIIKNSWSSMWGEQGYIRVA 312
Query: 146 YGSDQCLITSGPCSSTV 96
GS+QC +TS P SS V
Sbjct: 313 KGSNQCGLTSFPSSSVV 329
>ref|XP_804236.1| cruzipain precursor [Trypanosoma cruzi strain CL Brener]
gb|EAN82385.1| cruzipain precursor, putative [Trypanosoma cruzi]
Length = 247
Score = 156 bits (394), Expect = 2e-44
Identities = 70/127 (55%), Positives = 92/127 (72%)
Frame = -3
Query: 503 NGQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIG 324
NG + TE+SYPY V ATI+GHV+LPQ E Q+AAW NGPV++
Sbjct: 52 NGAVYTEDSYPYASGEGISPPCTTSGRT-VGATITGHVELPQDEAQIAAWLAVNGPVAVA 110
Query: 323 VDATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGY 144
VDA+SW TY GG++T+CVS+Q+DHGVL+VG++ + + PYWIIKNSW A WGE+GYIR+
Sbjct: 111 VDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTAQWGEDGYIRIAK 170
Query: 143 GSDQCLI 123
GS+QCL+
Sbjct: 171 GSNQCLV 177
>gb|EKF98349.1| cysteine peptidase, putative,cysteine peptidase, clan CA, family
C1, cathepsin L-like, putative, partial [Trypanosoma
cruzi]
Length = 226
Score = 155 bits (392), Expect = 2e-44
Identities = 70/136 (51%), Positives = 93/136 (68%)
Frame = -3
Query: 503 NGQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIG 324
NG + TE SYPY V ATI+GHV+LPQ E Q+AAW NGPV++
Sbjct: 13 NGAVYTEGSYPYASGEGISPPCTTSGHT-VGATITGHVELPQDEAQIAAWLAVNGPVAVA 71
Query: 323 VDATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGY 144
VDA+SW TY GG++T+CVS+Q+DHGVL+VG++ + + PYW+IKNSW WGE+GYIR+
Sbjct: 72 VDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWVIKNSWTTQWGEDGYIRIAK 131
Query: 143 GSDQCLITSGPCSSTV 96
GS+QCL+ S+ V
Sbjct: 132 GSNQCLVKEEASSAVV 147
>pdb|3HD3|A Chain A, High Resolution Crystal Structure Of Cruzain Bound To The
Vinyl Sulfone Inhibitor Smdc-256047
pdb|3HD3|B Chain B, High Resolution Crystal Structure Of Cruzain Bound To The
Vinyl Sulfone Inhibitor Smdc-256047
Length = 215
Score = 154 bits (390), Expect = 2e-44
Identities = 71/136 (52%), Positives = 92/136 (67%)
Frame = -3
Query: 503 NGQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIG 324
NG + TE+SYPY V ATI+GHV+LPQ E Q+AAW NGPV++
Sbjct: 80 NGAVYTEDSYPYASGEGISPPCTTSGHT-VGATITGHVELPQDEAQIAAWLAVNGPVAVA 138
Query: 323 VDATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGY 144
VDA+SW TY GG++T+CVS+Q+DHGVL+VG++ + PYWIIKNSW WGE GYIR+
Sbjct: 139 VDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDGAAVPYWIIKNSWTTQWGEEGYIRIAK 198
Query: 143 GSDQCLITSGPCSSTV 96
GS+QCL+ S+ V
Sbjct: 199 GSNQCLVKEEASSAVV 214
>ref|XP_009316281.1| cathepsin L-like protein [Trypanosoma grayi]
gb|KEG05488.1| cathepsin L-like protein [Trypanosoma grayi]
Length = 283
Score = 156 bits (395), Expect = 3e-44
Identities = 75/136 (55%), Positives = 92/136 (67%)
Frame = -3
Query: 503 NGQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIG 324
NG + TE SYPYV A ISG+ DLP E +MAAW +GP++I
Sbjct: 29 NGTVDTEASYPYVSGAGYSPKCRTASH-EFGAAISGYNDLPNDEDKMAAWLAVHGPIAIA 87
Query: 323 VDATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGY 144
VDATS+Q YMGG+LTNC+S+Q+DHGVL+VG+D + S PYWIIKNSWG SWGE GYIR+
Sbjct: 88 VDATSFQFYMGGVLTNCISEQLDHGVLLVGYDDSNSPPYWIIKNSWGTSWGEEGYIRIEK 147
Query: 143 GSDQCLITSGPCSSTV 96
G +QCL+ P SS V
Sbjct: 148 GKNQCLVNEYPTSSVV 163
>pdb|3IUT|A Chain A, The Crystal Structure of Cruzain in Complex with a
Tetrafluorophenoxymethyl Ketone Inhibitor
Length = 221
Score = 154 bits (390), Expect = 3e-44
Identities = 71/136 (52%), Positives = 92/136 (67%)
Frame = -3
Query: 503 NGQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIG 324
NG + TE+SYPY V ATI+GHV+LPQ E Q+AAW NGPV++
Sbjct: 80 NGAVYTEDSYPYASGEGISPPCTTSGHT-VGATITGHVELPQDEAQIAAWLAVNGPVAVA 138
Query: 323 VDATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGY 144
VDA+SW TY GG++T+CVS+Q+DHGVL+VG++ + PYWIIKNSW WGE GYIR+
Sbjct: 139 VDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDGAAVPYWIIKNSWTTQWGEEGYIRIAK 198
Query: 143 GSDQCLITSGPCSSTV 96
GS+QCL+ S+ V
Sbjct: 199 GSNQCLVKEEASSAVV 214
>gb|EKF27621.1| cysteine peptidase, putative, partial [Trypanosoma cruzi
marinkellei]
Length = 214
Score = 154 bits (389), Expect = 3e-44
Identities = 71/136 (52%), Positives = 91/136 (66%)
Frame = -3
Query: 503 NGQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIG 324
NG + TE SYPY V A I+GHV+LPQ E Q+AAW +NGPV++
Sbjct: 13 NGAVYTEESYPYASGEGISPPCTTSGHT-VGAMITGHVELPQDEAQIAAWLAANGPVAVA 71
Query: 323 VDATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGY 144
VDATSW TY GG++T+CVS+Q+DHGVL+VG++ + PYWIIKNSW WGE GYIR+
Sbjct: 72 VDATSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAPVPYWIIKNSWTTLWGEEGYIRIAK 131
Query: 143 GSDQCLITSGPCSSTV 96
GS+QCL+ S+ V
Sbjct: 132 GSNQCLVKEEASSAVV 147
>gb|ACI00341.1| cysteine proteinase, partial [Trypanosoma cruzi]
Length = 339
Score = 157 bits (398), Expect = 4e-44
Identities = 72/136 (52%), Positives = 95/136 (69%)
Frame = -3
Query: 503 NGQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIG 324
NG + TE+SYPY V ATI+GHV+LPQ E Q+AAW NGPV++
Sbjct: 74 NGAVYTEDSYPYASGEGISPPCTTSGHT-VGATITGHVELPQDEAQIAAWLAVNGPVAVA 132
Query: 323 VDATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGY 144
VDA+SW TY GG++T+CVS+Q+DHGVL+VG++ + + PYWIIKNSW A WGE+GYIR+
Sbjct: 133 VDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTAQWGEDGYIRIAK 192
Query: 143 GSDQCLITSGPCSSTV 96
GS+QCL+ S+ V
Sbjct: 193 GSNQCLVKEEASSAVV 208
>emb|CUG31439.1| cathepsin-L cysteine peptidase, putative, partial [Bodo saltans]
Length = 314
Score = 157 bits (396), Expect = 5e-44
Identities = 73/127 (57%), Positives = 88/127 (69%)
Frame = -3
Query: 500 GQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIGV 321
G + TE SYPYV ++ A I+G DLP+ E M WC GP+++GV
Sbjct: 189 GIVYTEASYPYVSGNGNVPSCSTSAAI-TGAVINGQFDLPKDEDAMGLWCGLKGPIAVGV 247
Query: 320 DATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGYG 141
DATSWQTYMGGI+T+C+S VDHGVLIVGFD T + PYWIIKNSWG +WGE GYIRV G
Sbjct: 248 DATSWQTYMGGIMTDCISSAVDHGVLIVGFDDTNNPPYWIIKNSWGPTWGEEGYIRVQKG 307
Query: 140 SDQCLIT 120
++QCLIT
Sbjct: 308 TNQCLIT 314
>gb|ACR07923.1| cysteine proteinase, partial [Trypanosoma cruzi]
Length = 345
Score = 157 bits (398), Expect = 5e-44
Identities = 72/136 (52%), Positives = 95/136 (69%)
Frame = -3
Query: 503 NGQIVTENSYPYVXXXXXXXXXXXXXSMPVAATISGHVDLPQTEQQMAAWCNSNGPVSIG 324
NG + TE+SYPY V ATI+GHV+LPQ E Q+AAW NGPV++
Sbjct: 80 NGAVYTEDSYPYASGEGISPPCTTSGHT-VGATITGHVELPQDEAQIAAWLAVNGPVAVA 138
Query: 323 VDATSWQTYMGGILTNCVSQQVDHGVLIVGFDLTYSTPYWIIKNSWGASWGENGYIRVGY 144
VDA+SW TY GG++T+CVS+Q+DHGVL+VG++ + + PYWIIKNSW A WGE+GYIR+
Sbjct: 139 VDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTAQWGEDGYIRIAK 198
Query: 143 GSDQCLITSGPCSSTV 96
GS+QCL+ S+ V
Sbjct: 199 GSNQCLVKEEASSAVV 214