BLASTX nr result
ID: Rheum21_contig00016419
seq
BLASTX 2.2.25 [Feb-01-2011] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= Rheum21_contig00016419 (314 letters) Database: ./nr 37,332,560 sequences; 13,225,080,153 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gb|ESW27746.1| hypothetical protein PHAVU_003G228700g [Phaseolus... 166 3e-39 gb|ESW27745.1| hypothetical protein PHAVU_003G228700g [Phaseolus... 166 3e-39 ref|XP_006579678.1| PREDICTED: type I inositol 1,4,5-trisphospha... 165 5e-39 ref|XP_006579677.1| PREDICTED: type I inositol 1,4,5-trisphospha... 165 5e-39 ref|XP_003549972.1| PREDICTED: type I inositol 1,4,5-trisphospha... 164 1e-38 ref|XP_004300272.1| PREDICTED: type I inositol 1,4,5-trisphospha... 162 3e-38 gb|EOY24072.1| Type I inositol polyphosphate 5-phosphatase, puta... 161 7e-38 gb|EXB99791.1| Type I inositol-1,4,5-trisphosphate 5-phosphatase... 160 1e-37 ref|XP_002279188.2| PREDICTED: type I inositol-1,4,5-trisphospha... 160 1e-37 gb|ESW28638.1| hypothetical protein PHAVU_002G005300g [Phaseolus... 160 2e-37 ref|XP_006358576.1| PREDICTED: type I inositol 1,4,5-trisphospha... 159 4e-37 ref|XP_002329580.1| predicted protein [Populus trichocarpa] 159 4e-37 ref|NP_001234789.1| inositol-1,4,5-triphosphate-5-phosphatase [S... 159 4e-37 ref|XP_002304376.2| hypothetical protein POPTR_0003s08660g [Popu... 159 5e-37 gb|EMJ11843.1| hypothetical protein PRUPE_ppa020388mg [Prunus pe... 159 5e-37 ref|XP_006485411.1| PREDICTED: type I inositol 1,4,5-trisphospha... 158 8e-37 ref|XP_006485410.1| PREDICTED: type I inositol 1,4,5-trisphospha... 158 8e-37 ref|XP_006485408.1| PREDICTED: type I inositol 1,4,5-trisphospha... 158 8e-37 ref|XP_006436786.1| hypothetical protein CICLE_v10030898mg [Citr... 158 8e-37 ref|XP_006436785.1| hypothetical protein CICLE_v10030898mg [Citr... 158 8e-37 >gb|ESW27746.1| hypothetical protein PHAVU_003G228700g [Phaseolus vulgaris] Length = 622 Score = 166 bits (420), Expect = 3e-39 Identities = 76/101 (75%), Positives = 89/101 (88%) Frame = +2 Query: 11 RGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYVL 190 +GY++RHRRGKS+TLR QYI K+VRVTIGTWNVAG+IP +L+IE+WLC EPADIY++ Sbjct: 78 KGYKVRHRRGKSETLRVQYINTKEVRVTIGTWNVAGRIPCKDLEIEDWLCTDEPADIYII 137 Query: 191 GFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 GFQEVVPLNAGNVLGAEDNTPIR WE IIRR LN +S+ ES Sbjct: 138 GFQEVVPLNAGNVLGAEDNTPIRNWEAIIRRTLNKSSEPES 178 >gb|ESW27745.1| hypothetical protein PHAVU_003G228700g [Phaseolus vulgaris] Length = 466 Score = 166 bits (420), Expect = 3e-39 Identities = 76/101 (75%), Positives = 89/101 (88%) Frame = +2 Query: 11 RGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYVL 190 +GY++RHRRGKS+TLR QYI K+VRVTIGTWNVAG+IP +L+IE+WLC EPADIY++ Sbjct: 78 KGYKVRHRRGKSETLRVQYINTKEVRVTIGTWNVAGRIPCKDLEIEDWLCTDEPADIYII 137 Query: 191 GFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 GFQEVVPLNAGNVLGAEDNTPIR WE IIRR LN +S+ ES Sbjct: 138 GFQEVVPLNAGNVLGAEDNTPIRNWEAIIRRTLNKSSEPES 178 >ref|XP_006579678.1| PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase 2-like isoform X2 [Glycine max] Length = 468 Score = 165 bits (418), Expect = 5e-39 Identities = 75/101 (74%), Positives = 88/101 (87%) Frame = +2 Query: 11 RGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYVL 190 +GY+ RH+RGKS+TLR QYI K+VRVTIGTWNVAG+ P +LDIE+WLC EPADIY++ Sbjct: 78 KGYKTRHKRGKSETLRVQYINTKEVRVTIGTWNVAGRAPSKDLDIEDWLCTNEPADIYII 137 Query: 191 GFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 GFQEVVPL+AGNVLGAEDNTPIRKWE IIRR LN +S+ ES Sbjct: 138 GFQEVVPLSAGNVLGAEDNTPIRKWEAIIRRTLNKSSEPES 178 >ref|XP_006579677.1| PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase 2-like isoform X1 [Glycine max] Length = 624 Score = 165 bits (418), Expect = 5e-39 Identities = 75/101 (74%), Positives = 88/101 (87%) Frame = +2 Query: 11 RGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYVL 190 +GY+ RH+RGKS+TLR QYI K+VRVTIGTWNVAG+ P +LDIE+WLC EPADIY++ Sbjct: 78 KGYKTRHKRGKSETLRVQYINTKEVRVTIGTWNVAGRAPSKDLDIEDWLCTNEPADIYII 137 Query: 191 GFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 GFQEVVPL+AGNVLGAEDNTPIRKWE IIRR LN +S+ ES Sbjct: 138 GFQEVVPLSAGNVLGAEDNTPIRKWEAIIRRTLNKSSEPES 178 >ref|XP_003549972.1| PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase 2-like [Glycine max] Length = 629 Score = 164 bits (414), Expect = 1e-38 Identities = 74/101 (73%), Positives = 87/101 (86%) Frame = +2 Query: 11 RGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYVL 190 +GY +HRRGKS+TLR QYI K++RVTIGTWNVAG+ P +LDIE+WLC EPADIY++ Sbjct: 79 KGYNTKHRRGKSETLRVQYINTKELRVTIGTWNVAGRAPSKDLDIEDWLCTNEPADIYII 138 Query: 191 GFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 GFQEVVPL+AGNVLGAEDNTPIRKWE IIRR LN +S+ ES Sbjct: 139 GFQEVVPLSAGNVLGAEDNTPIRKWEAIIRRTLNKSSEPES 179 >ref|XP_004300272.1| PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase 2-like [Fragaria vesca subsp. vesca] Length = 640 Score = 162 bits (411), Expect = 3e-38 Identities = 76/102 (74%), Positives = 87/102 (85%) Frame = +2 Query: 8 SRGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYV 187 S GYQLRHRRGKS+T RAQYIK KDVRVTIGTWNVAG +PD +LDI++W+ +EP+DIY+ Sbjct: 84 SFGYQLRHRRGKSETTRAQYIKTKDVRVTIGTWNVAGTVPDEDLDIDDWISSEEPSDIYI 143 Query: 188 LGFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 LGFQEVVPLNAGNV GAEDN PI KWE IIRR LN + + ES Sbjct: 144 LGFQEVVPLNAGNVFGAEDNKPIPKWEAIIRRTLNKSLEPES 185 >gb|EOY24072.1| Type I inositol polyphosphate 5-phosphatase, putative isoform 1 [Theobroma cacao] gi|508776817|gb|EOY24073.1| Type I inositol polyphosphate 5-phosphatase, putative isoform 1 [Theobroma cacao] Length = 633 Score = 161 bits (408), Expect = 7e-38 Identities = 75/102 (73%), Positives = 88/102 (86%) Frame = +2 Query: 8 SRGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYV 187 S+GYQLRHRRGKS+TLRAQYI KDVRVTIGTWNVAG++P +L+I++WLC E ADIY+ Sbjct: 80 SKGYQLRHRRGKSETLRAQYINTKDVRVTIGTWNVAGRLPCEDLEIDDWLCTNEQADIYI 139 Query: 188 LGFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 +GFQEVVPLNAGNVLGAED+ PI KWE IIRR LN + + ES Sbjct: 140 IGFQEVVPLNAGNVLGAEDSRPIPKWEAIIRRTLNKSFEPES 181 >gb|EXB99791.1| Type I inositol-1,4,5-trisphosphate 5-phosphatase 2 [Morus notabilis] Length = 640 Score = 160 bits (406), Expect = 1e-37 Identities = 73/99 (73%), Positives = 87/99 (87%) Frame = +2 Query: 8 SRGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYV 187 S+GYQ RHRRGKS+TLR QYI KD+RVTIG+WNVAG+IP +LDIE+WLC +EPADIY+ Sbjct: 88 SKGYQSRHRRGKSETLRVQYINTKDLRVTIGSWNVAGRIPGEDLDIEDWLCTEEPADIYI 147 Query: 188 LGFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASD 304 +GFQEVVPLNAGNVLGAED+ PI KWE IIR+ LN +S+ Sbjct: 148 IGFQEVVPLNAGNVLGAEDSKPIPKWEAIIRKTLNKSSE 186 >ref|XP_002279188.2| PREDICTED: type I inositol-1,4,5-trisphosphate 5-phosphatase 2-like [Vitis vinifera] gi|297742162|emb|CBI33949.3| unnamed protein product [Vitis vinifera] Length = 628 Score = 160 bits (406), Expect = 1e-37 Identities = 73/104 (70%), Positives = 88/104 (84%) Frame = +2 Query: 2 NHSRGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADI 181 + S+GY HRRGKS+TLR YI KD+R+TIGTWNVAG++P+ +L+IEEWLCM+EPADI Sbjct: 76 SESKGYSSSHRRGKSETLRVHYINRKDIRLTIGTWNVAGRLPNEDLEIEEWLCMQEPADI 135 Query: 182 YVLGFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 Y+LGFQEVVPLNAGNVLGAED+ PI KWE IIRR LN + + ES Sbjct: 136 YILGFQEVVPLNAGNVLGAEDSQPIPKWEAIIRRTLNKSFEPES 179 >gb|ESW28638.1| hypothetical protein PHAVU_002G005300g [Phaseolus vulgaris] gi|561030060|gb|ESW28639.1| hypothetical protein PHAVU_002G005300g [Phaseolus vulgaris] Length = 622 Score = 160 bits (404), Expect = 2e-37 Identities = 73/101 (72%), Positives = 90/101 (89%) Frame = +2 Query: 11 RGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYVL 190 +G + RHRRGKS+TLRAQYI K+VRVTIGTWNVAG+ P +L+I++WLC ++PADIY+L Sbjct: 80 KGQKARHRRGKSETLRAQYINTKEVRVTIGTWNVAGRHPYEDLEIDDWLCTEDPADIYIL 139 Query: 191 GFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 GFQEVVPLNAGNVLGAEDNTPI+KWE IIRR+LN +S+ +S Sbjct: 140 GFQEVVPLNAGNVLGAEDNTPIQKWEAIIRRSLNKSSEPDS 180 >ref|XP_006358576.1| PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase 2-like [Solanum tuberosum] Length = 632 Score = 159 bits (402), Expect = 4e-37 Identities = 72/99 (72%), Positives = 85/99 (85%) Frame = +2 Query: 17 YQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYVLGF 196 Y RHRRGKS+TLRAQYI K+VRVT+GTWNVAG++PD +LDI+EWLCM+EPADIY+LGF Sbjct: 84 YTPRHRRGKSETLRAQYINTKEVRVTVGTWNVAGRLPDEDLDIDEWLCMQEPADIYILGF 143 Query: 197 QEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 QEVVPLNAGNVLGAE+ P+ KWE IIRR LN + E+ Sbjct: 144 QEVVPLNAGNVLGAENRRPVPKWETIIRRTLNRTEEPET 182 >ref|XP_002329580.1| predicted protein [Populus trichocarpa] Length = 643 Score = 159 bits (402), Expect = 4e-37 Identities = 74/102 (72%), Positives = 86/102 (84%) Frame = +2 Query: 8 SRGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYV 187 S+GY HRRGKS+TLRAQYI KDVRVTIGTWNVAG++P+ +LDI+ WLC +EPADIY+ Sbjct: 84 SKGYSSGHRRGKSETLRAQYINTKDVRVTIGTWNVAGRLPNEDLDIDSWLCPEEPADIYI 143 Query: 188 LGFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 +GFQEVVPLNAGNVLGAE + PI KWE IIRR LN + AES Sbjct: 144 IGFQEVVPLNAGNVLGAESSRPIPKWEAIIRRTLNKSHQAES 185 >ref|NP_001234789.1| inositol-1,4,5-triphosphate-5-phosphatase [Solanum lycopersicum] gi|157863708|gb|ABV90875.1| inositol-1,4,5-triphosphate-5-phosphatase [Solanum lycopersicum] Length = 630 Score = 159 bits (402), Expect = 4e-37 Identities = 72/99 (72%), Positives = 85/99 (85%) Frame = +2 Query: 17 YQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYVLGF 196 Y RHRRGKS+TLRAQYI K+VRVT+GTWNVAG++PD +LDI+EWLCM+EPADIY+LGF Sbjct: 84 YTPRHRRGKSETLRAQYINTKEVRVTVGTWNVAGRLPDEDLDIDEWLCMQEPADIYILGF 143 Query: 197 QEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 QEVVPLNAGNVLGAE+ P+ KWE IIRR LN + E+ Sbjct: 144 QEVVPLNAGNVLGAENRRPVPKWEAIIRRTLNRTEEPET 182 >ref|XP_002304376.2| hypothetical protein POPTR_0003s08660g [Populus trichocarpa] gi|550342745|gb|EEE79355.2| hypothetical protein POPTR_0003s08660g [Populus trichocarpa] Length = 643 Score = 159 bits (401), Expect = 5e-37 Identities = 73/102 (71%), Positives = 86/102 (84%) Frame = +2 Query: 8 SRGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYV 187 S+GY HRRGKS+TLRAQYI KDVRVT+GTWNVAG++P+ +LDI+ WLC +EPADIY+ Sbjct: 84 SKGYSSGHRRGKSETLRAQYINTKDVRVTVGTWNVAGRLPNEDLDIDSWLCPEEPADIYI 143 Query: 188 LGFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 +GFQEVVPLNAGNVLGAE + PI KWE IIRR LN + AES Sbjct: 144 IGFQEVVPLNAGNVLGAESSRPIPKWEAIIRRTLNKSHQAES 185 >gb|EMJ11843.1| hypothetical protein PRUPE_ppa020388mg [Prunus persica] Length = 611 Score = 159 bits (401), Expect = 5e-37 Identities = 71/102 (69%), Positives = 88/102 (86%) Frame = +2 Query: 8 SRGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYV 187 S+GYQL+HRRGKS+T+RAQYI KDVRVT+G+WNV G++P +LDI++WLC +EPAD+Y+ Sbjct: 55 SKGYQLKHRRGKSETVRAQYINTKDVRVTVGSWNVGGRLPYEDLDIDDWLCTEEPADVYI 114 Query: 188 LGFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 LGFQEVVPLNAGNVLGAEDN I KWE IIR+ LN + + ES Sbjct: 115 LGFQEVVPLNAGNVLGAEDNKSIPKWEAIIRKTLNKSLEPES 156 >ref|XP_006485411.1| PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase 2-like isoform X4 [Citrus sinensis] Length = 640 Score = 158 bits (399), Expect = 8e-37 Identities = 73/102 (71%), Positives = 86/102 (84%) Frame = +2 Query: 8 SRGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYV 187 S+GY LRHRRGKS+TLR QYI KDVRVTIGTWNVAG+ P +LDI++WLC +EPADIY+ Sbjct: 63 SKGYHLRHRRGKSETLRVQYINTKDVRVTIGTWNVAGRQPYEDLDIDDWLCTQEPADIYI 122 Query: 188 LGFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 GFQEVVPLNAGNVLGAE + PI KWE IIRR LN +++ E+ Sbjct: 123 FGFQEVVPLNAGNVLGAESSRPIPKWEAIIRRTLNKSAEPEN 164 >ref|XP_006485410.1| PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase 2-like isoform X3 [Citrus sinensis] Length = 653 Score = 158 bits (399), Expect = 8e-37 Identities = 73/102 (71%), Positives = 86/102 (84%) Frame = +2 Query: 8 SRGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYV 187 S+GY LRHRRGKS+TLR QYI KDVRVTIGTWNVAG+ P +LDI++WLC +EPADIY+ Sbjct: 80 SKGYHLRHRRGKSETLRVQYINTKDVRVTIGTWNVAGRQPYEDLDIDDWLCTQEPADIYI 139 Query: 188 LGFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 GFQEVVPLNAGNVLGAE + PI KWE IIRR LN +++ E+ Sbjct: 140 FGFQEVVPLNAGNVLGAESSRPIPKWEAIIRRTLNKSAEPEN 181 >ref|XP_006485408.1| PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase 2-like isoform X1 [Citrus sinensis] Length = 657 Score = 158 bits (399), Expect = 8e-37 Identities = 73/102 (71%), Positives = 86/102 (84%) Frame = +2 Query: 8 SRGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYV 187 S+GY LRHRRGKS+TLR QYI KDVRVTIGTWNVAG+ P +LDI++WLC +EPADIY+ Sbjct: 80 SKGYHLRHRRGKSETLRVQYINTKDVRVTIGTWNVAGRQPYEDLDIDDWLCTQEPADIYI 139 Query: 188 LGFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 GFQEVVPLNAGNVLGAE + PI KWE IIRR LN +++ E+ Sbjct: 140 FGFQEVVPLNAGNVLGAESSRPIPKWEAIIRRTLNKSAEPEN 181 >ref|XP_006436786.1| hypothetical protein CICLE_v10030898mg [Citrus clementina] gi|557538982|gb|ESR50026.1| hypothetical protein CICLE_v10030898mg [Citrus clementina] Length = 666 Score = 158 bits (399), Expect = 8e-37 Identities = 73/102 (71%), Positives = 86/102 (84%) Frame = +2 Query: 8 SRGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYV 187 S+GY LRHRRGKS+TLR QYI KDVRVTIGTWNVAG+ P +LDI++WLC +EPADIY+ Sbjct: 80 SKGYHLRHRRGKSETLRVQYINTKDVRVTIGTWNVAGRQPYEDLDIDDWLCTQEPADIYI 139 Query: 188 LGFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 GFQEVVPLNAGNVLGAE + PI KWE IIRR LN +++ E+ Sbjct: 140 FGFQEVVPLNAGNVLGAESSRPIPKWEAIIRRTLNKSAEPEN 181 >ref|XP_006436785.1| hypothetical protein CICLE_v10030898mg [Citrus clementina] gi|568864018|ref|XP_006485409.1| PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase 2-like isoform X2 [Citrus sinensis] gi|557538981|gb|ESR50025.1| hypothetical protein CICLE_v10030898mg [Citrus clementina] Length = 656 Score = 158 bits (399), Expect = 8e-37 Identities = 73/102 (71%), Positives = 86/102 (84%) Frame = +2 Query: 8 SRGYQLRHRRGKSDTLRAQYIKNKDVRVTIGTWNVAGKIPDANLDIEEWLCMKEPADIYV 187 S+GY LRHRRGKS+TLR QYI KDVRVTIGTWNVAG+ P +LDI++WLC +EPADIY+ Sbjct: 80 SKGYHLRHRRGKSETLRVQYINTKDVRVTIGTWNVAGRQPYEDLDIDDWLCTQEPADIYI 139 Query: 188 LGFQEVVPLNAGNVLGAEDNTPIRKWEEIIRRALNGASDAES 313 GFQEVVPLNAGNVLGAE + PI KWE IIRR LN +++ E+ Sbjct: 140 FGFQEVVPLNAGNVLGAESSRPIPKWEAIIRRTLNKSAEPEN 181