BLASTX 2.2.26 [Sep-21-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Rehmannia31_contig00021513
         (465 letters)

Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects 
           149,584,005 sequences; 54,822,741,787 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

ref|XP_020549276.1| heparanase-like protein 3 isoform X2 [Sesamu...   134   2e-35
ref|XP_011078541.1| heparanase-like protein 3 isoform X1 [Sesamu...   134   4e-34
gb|PIN22219.1| Beta-glucuronidase [Handroanthus impetiginosus]        127   3e-31
ref|XP_022842392.1| heparanase-like protein 3 isoform X2 [Olea e...   112   4e-26
ref|XP_022842391.1| heparanase-like protein 3 isoform X1 [Olea e...   112   4e-26
gb|KZV30089.1| heparanase-like protein 3-like [Dorcoceras hygrom...   112   6e-26
ref|XP_019230408.1| PREDICTED: heparanase-like protein 3 [Nicoti...   110   4e-25
ref|XP_016493875.1| PREDICTED: heparanase-like protein 3 [Nicoti...   109   7e-25
ref|XP_009625836.1| PREDICTED: heparanase-like protein 3 [Nicoti...   109   7e-25
ref|XP_016511107.1| PREDICTED: heparanase-like protein 3 [Nicoti...   108   1e-24
ref|XP_009757548.1| PREDICTED: heparanase-like protein 3 [Nicoti...   108   1e-24
ref|XP_015082126.1| PREDICTED: heparanase-like protein 3 isoform...   107   1e-24
ref|XP_015082125.1| PREDICTED: heparanase-like protein 3 isoform...   107   3e-24
ref|XP_004242732.1| PREDICTED: heparanase-like protein 3 [Solanu...   107   3e-24
ref|XP_006359499.1| PREDICTED: heparanase-like protein 3 [Solanu...   107   5e-24
ref|XP_016552931.1| PREDICTED: heparanase-like protein 3 isoform...   105   1e-23
gb|PHU11298.1| Heparanase-like protein 3 [Capsicum chinense]          105   2e-23
ref|XP_016552930.1| PREDICTED: heparanase-like protein 3 isoform...   105   2e-23
gb|KNA04466.1| hypothetical protein SOVF_199420, partial [Spinac...   104   3e-23
ref|XP_022845357.1| heparanase-like protein 3 [Olea europaea var...   104   3e-23

>ref|XP_020549276.1| heparanase-like protein 3 isoform X2 [Sesamum indicum]
          Length = 341

 Score =  134 bits (338), Expect = 2e-35
 Identities = 72/112 (64%), Positives = 79/112 (70%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           NTTV  +V+F GTL                 PLH  KQ  G VREEYHLTP+DGNIQS+T
Sbjct: 232 NTTVHAKVDFNGTLTRLRKHRHHRHRST-ATPLHHNKQVSGKVREEYHLTPADGNIQSRT 290

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPACR 337
           +LLN K LTV+ SSGLIP LEPVRVNSSEPI VAPYSIVFV MP  A+PACR
Sbjct: 291 ILLNGKALTVN-SSGLIPVLEPVRVNSSEPIMVAPYSIVFVHMPNAAVPACR 341


>ref|XP_011078541.1| heparanase-like protein 3 isoform X1 [Sesamum indicum]
          Length = 537

 Score =  134 bits (338), Expect = 4e-34
 Identities = 72/112 (64%), Positives = 79/112 (70%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           NTTV  +V+F GTL                 PLH  KQ  G VREEYHLTP+DGNIQS+T
Sbjct: 428 NTTVHAKVDFNGTLTRLRKHRHHRHRST-ATPLHHNKQVSGKVREEYHLTPADGNIQSRT 486

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPACR 337
           +LLN K LTV+ SSGLIP LEPVRVNSSEPI VAPYSIVFV MP  A+PACR
Sbjct: 487 ILLNGKALTVN-SSGLIPVLEPVRVNSSEPIMVAPYSIVFVHMPNAAVPACR 537


>gb|PIN22219.1| Beta-glucuronidase [Handroanthus impetiginosus]
          Length = 537

 Score =  127 bits (318), Expect = 3e-31
 Identities = 72/113 (63%), Positives = 78/113 (69%), Gaps = 1/113 (0%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXX-PKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQ 178
           NTTVQ ++ F GT M               V+PL  RKQA  + REEYHLTP  GNIQSQ
Sbjct: 426 NTTVQAKLNFNGTFMYLHKHRHHHHRHRSNVSPLPHRKQASVAFREEYHLTPMGGNIQSQ 485

Query: 179 TVLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPACR 337
            VLLN K L VD SSGLIPALEPVRVNSS+PITVA YSIVFV MP V +PACR
Sbjct: 486 IVLLNGKELRVD-SSGLIPALEPVRVNSSDPITVASYSIVFVHMPSVVLPACR 537


>ref|XP_022842392.1| heparanase-like protein 3 isoform X2 [Olea europaea var.
           sylvestris]
          Length = 517

 Score =  112 bits (281), Expect = 4e-26
 Identities = 63/112 (56%), Positives = 75/112 (66%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           N TV+ +V F GTL+             KV+ +HQ  +A G+ REEYHLT  DGNIQSQT
Sbjct: 409 NNTVEAKVNFNGTLVDRHEDRHHRHRS-KVSKMHQANEARGT-REEYHLTAMDGNIQSQT 466

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPACR 337
           +LLN K L  D SSG IP LEP+ V SSEPI VA +SI FV MPYVA+PAC+
Sbjct: 467 MLLNGKALITD-SSGAIPLLEPITVTSSEPIRVASFSIAFVHMPYVALPACK 517


>ref|XP_022842391.1| heparanase-like protein 3 isoform X1 [Olea europaea var.
           sylvestris]
          Length = 536

 Score =  112 bits (281), Expect = 4e-26
 Identities = 63/112 (56%), Positives = 75/112 (66%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           N TV+ +V F GTL+             KV+ +HQ  +A G+ REEYHLT  DGNIQSQT
Sbjct: 428 NNTVEAKVNFNGTLVDRHEDRHHRHRS-KVSKMHQANEARGT-REEYHLTAMDGNIQSQT 485

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPACR 337
           +LLN K L  D SSG IP LEP+ V SSEPI VA +SI FV MPYVA+PAC+
Sbjct: 486 MLLNGKALITD-SSGAIPLLEPITVTSSEPIRVASFSIAFVHMPYVALPACK 536


>gb|KZV30089.1| heparanase-like protein 3-like [Dorcoceras hygrometricum]
          Length = 573

 Score =  112 bits (280), Expect = 6e-26
 Identities = 68/121 (56%), Positives = 73/121 (60%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           NTTV    +  GT +             KV  L   KQ     REEYHLTP DGNI+SQT
Sbjct: 430 NTTVHAAPDISGTSIEVHKRRRHHRHRSKVILLPHNKQLSVPTREEYHLTPLDGNIRSQT 489

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPACR*MEVEISS 361
           VLLN KPLTVD SSG IPALEP   NSSEPITVAPYSIVFV +P VAI A   + V    
Sbjct: 490 VLLNGKPLTVD-SSGAIPALEPSFFNSSEPITVAPYSIVFVHLPSVAIQASSLLRVPFFE 548

Query: 362 I 364
           I
Sbjct: 549 I 549


>ref|XP_019230408.1| PREDICTED: heparanase-like protein 3 [Nicotiana attenuata]
 gb|OIT29452.1| heparanase-like protein 3 [Nicotiana attenuata]
          Length = 538

 Score =  110 bits (274), Expect = 4e-25
 Identities = 56/111 (50%), Positives = 73/111 (65%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           NTT+   V F GTL+                 L + ++   + R+EYHLT  DG++QSQT
Sbjct: 428 NTTISANVAFNGTLLHHRKHSHHSHKKSSSIRLPKSRKIASNTRQEYHLTAKDGDLQSQT 487

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPAC 334
           +LLN KPL +D SSG IP LEP+ VNS+EP+TVAP+SIVFV +PYV +PAC
Sbjct: 488 MLLNGKPLAID-SSGNIPPLEPIFVNSTEPLTVAPFSIVFVHIPYVILPAC 537


>ref|XP_016493875.1| PREDICTED: heparanase-like protein 3 [Nicotiana tabacum]
          Length = 538

 Score =  109 bits (272), Expect = 7e-25
 Identities = 54/111 (48%), Positives = 75/111 (67%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           NTT++  + F GTL+                 L + ++   + R+EYHLT  DG++QSQT
Sbjct: 428 NTTIRANIAFNGTLLHHRKHRHHSHRKSSSIRLPKSRKIASNTRQEYHLTAKDGDLQSQT 487

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPAC 334
           +LLN KPLT+D S G IP+LEP+ VNS+EP+TVAP+SI+FV +PYV +PAC
Sbjct: 488 MLLNGKPLTID-SFGNIPSLEPIFVNSTEPLTVAPFSILFVHIPYVILPAC 537


>ref|XP_009625836.1| PREDICTED: heparanase-like protein 3 [Nicotiana tomentosiformis]
          Length = 538

 Score =  109 bits (272), Expect = 7e-25
 Identities = 54/111 (48%), Positives = 75/111 (67%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           NTT++  + F GTL+                 L + ++   + R+EYHLT  DG++QSQT
Sbjct: 428 NTTIRANIAFNGTLLHHRKHRHHSHRKSSSIRLPKSRKIASNTRQEYHLTAKDGDLQSQT 487

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPAC 334
           +LLN KPLT+D S G IP+LEP+ VNS+EP+TVAP+SI+FV +PYV +PAC
Sbjct: 488 MLLNGKPLTID-SFGNIPSLEPIFVNSTEPLTVAPFSILFVHIPYVILPAC 537


>ref|XP_016511107.1| PREDICTED: heparanase-like protein 3 [Nicotiana tabacum]
          Length = 538

 Score =  108 bits (271), Expect = 1e-24
 Identities = 55/111 (49%), Positives = 74/111 (66%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           NTT+   V F GT++                 L + ++   + R+EYHLT  DG++QSQT
Sbjct: 428 NTTMSANVAFNGTMLHQRKHRHHSHRKSSSIRLPKSRKIASNTRQEYHLTAKDGDLQSQT 487

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPAC 334
           +LLN KPLT+D S G IP+LEP+ VNS+EP+TVAP+SIVFV +PYV +PAC
Sbjct: 488 MLLNGKPLTID-SFGNIPSLEPIFVNSTEPLTVAPFSIVFVHIPYVILPAC 537


>ref|XP_009757548.1| PREDICTED: heparanase-like protein 3 [Nicotiana sylvestris]
          Length = 538

 Score =  108 bits (271), Expect = 1e-24
 Identities = 55/111 (49%), Positives = 74/111 (66%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           NTT+   V F GT++                 L + ++   + R+EYHLT  DG++QSQT
Sbjct: 428 NTTMSANVAFNGTMLHQRKHRHHSHRKSSSIRLPKSRKIASNTRQEYHLTAKDGDLQSQT 487

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPAC 334
           +LLN KPLT+D S G IP+LEP+ VNS+EP+TVAP+SIVFV +PYV +PAC
Sbjct: 488 MLLNGKPLTID-SFGNIPSLEPIFVNSTEPLTVAPFSIVFVHIPYVILPAC 537


>ref|XP_015082126.1| PREDICTED: heparanase-like protein 3 isoform X2 [Solanum pennellii]
          Length = 413

 Score =  107 bits (267), Expect = 1e-24
 Identities = 56/111 (50%), Positives = 71/111 (63%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           NTT+ +RV+F GT++                 L +  +   + REEYHLT  DGN+QSQT
Sbjct: 303 NTTIHSRVDFNGTMLHQQKHRHHHNHRKSSIKLPRSNKIASNTREEYHLTAKDGNLQSQT 362

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPAC 334
           +LLN K L VD SSG IP  EP+ VNS+E IT+AP SIVFV +PYV +PAC
Sbjct: 363 MLLNGKALIVD-SSGNIPTFEPIYVNSTEAITIAPLSIVFVHIPYVLLPAC 412


>ref|XP_015082125.1| PREDICTED: heparanase-like protein 3 isoform X1 [Solanum pennellii]
          Length = 536

 Score =  107 bits (267), Expect = 3e-24
 Identities = 56/111 (50%), Positives = 71/111 (63%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           NTT+ +RV+F GT++                 L +  +   + REEYHLT  DGN+QSQT
Sbjct: 426 NTTIHSRVDFNGTMLHQQKHRHHHNHRKSSIKLPRSNKIASNTREEYHLTAKDGNLQSQT 485

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPAC 334
           +LLN K L VD SSG IP  EP+ VNS+E IT+AP SIVFV +PYV +PAC
Sbjct: 486 MLLNGKALIVD-SSGNIPTFEPIYVNSTEAITIAPLSIVFVHIPYVLLPAC 535


>ref|XP_004242732.1| PREDICTED: heparanase-like protein 3 [Solanum lycopersicum]
          Length = 536

 Score =  107 bits (267), Expect = 3e-24
 Identities = 57/111 (51%), Positives = 70/111 (63%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           NTT+  RV+F GT++                 L +  +   + REEYHLT  DGN+QSQT
Sbjct: 426 NTTIHPRVDFNGTMLHQQKHRHHHNHRKSSIKLPRSNKVASNTREEYHLTAKDGNLQSQT 485

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPAC 334
           +LLN K L VD SSG IP  EP+ VNS+E ITVAP SIVFV +PYV +PAC
Sbjct: 486 MLLNGKALIVD-SSGNIPTFEPIYVNSTEAITVAPLSIVFVHIPYVLLPAC 535


>ref|XP_006359499.1| PREDICTED: heparanase-like protein 3 [Solanum tuberosum]
          Length = 536

 Score =  107 bits (266), Expect = 5e-24
 Identities = 56/111 (50%), Positives = 70/111 (63%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           NTT+  RV+F GT++                 L +  +   + REEYHLT  DGN+QSQT
Sbjct: 426 NTTIHARVDFNGTMLHRRKHRHHHNHRKSSIKLPRSSKIASNTREEYHLTAKDGNLQSQT 485

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPAC 334
           +LLN   L VD SSG IP  EP+ VNS+E ITVAP+SIVFV +PYV +PAC
Sbjct: 486 MLLNGNALIVD-SSGNIPTFEPIYVNSTEAITVAPFSIVFVHIPYVLLPAC 535


>ref|XP_016552931.1| PREDICTED: heparanase-like protein 3 isoform X2 [Capsicum annuum]
          Length = 469

 Score =  105 bits (262), Expect = 1e-23
 Identities = 55/111 (49%), Positives = 71/111 (63%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           NTT+  RV+F GT++                 L +  +   + REEYHLT  DG++QSQT
Sbjct: 359 NTTIHARVDFNGTMLHRRKHRRHHSLRKSSIQLSKSSKIASNTREEYHLTAKDGDLQSQT 418

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPAC 334
           +LLN   LTVD S G IP L+P+ VNS+E ITVAP+SIVFV +PYV +PAC
Sbjct: 419 MLLNGNALTVD-SFGNIPTLDPIFVNSTEAITVAPFSIVFVHIPYVLLPAC 468


>gb|PHU11298.1| Heparanase-like protein 3 [Capsicum chinense]
          Length = 537

 Score =  105 bits (262), Expect = 2e-23
 Identities = 55/111 (49%), Positives = 71/111 (63%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           NTT+  RV+F GT++                 L +  +   + REEYHLT  DG++QSQT
Sbjct: 427 NTTIHARVDFNGTMLHRRKHRRHHSLRKSSIQLSKSSKIASNTREEYHLTAKDGDLQSQT 486

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPAC 334
           +LLN   LTVD S G IP L+P+ VNS+E ITVAP+SIVFV +PYV +PAC
Sbjct: 487 MLLNGNALTVD-SFGNIPTLDPIFVNSTEAITVAPFSIVFVHIPYVLLPAC 536


>ref|XP_016552930.1| PREDICTED: heparanase-like protein 3 isoform X1 [Capsicum annuum]
 gb|PHT75496.1| Heparanase-like protein 3 [Capsicum annuum]
          Length = 537

 Score =  105 bits (262), Expect = 2e-23
 Identities = 55/111 (49%), Positives = 71/111 (63%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           NTT+  RV+F GT++                 L +  +   + REEYHLT  DG++QSQT
Sbjct: 427 NTTIHARVDFNGTMLHRRKHRRHHSLRKSSIQLSKSSKIASNTREEYHLTAKDGDLQSQT 486

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPAC 334
           +LLN   LTVD S G IP L+P+ VNS+E ITVAP+SIVFV +PYV +PAC
Sbjct: 487 MLLNGNALTVD-SFGNIPTLDPIFVNSTEAITVAPFSIVFVHIPYVLLPAC 536


>gb|KNA04466.1| hypothetical protein SOVF_199420, partial [Spinacia oleracea]
          Length = 448

 Score =  104 bits (259), Expect = 3e-23
 Identities = 56/112 (50%), Positives = 73/112 (65%)
 Frame = +2

Query: 2   NTTVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQT 181
           NTT++T V F GT               +    HQ K+A   VR EYHLT  DG++QSQT
Sbjct: 339 NTTIETNVAFNGTWSLPHMHHHMHKNRGRAMKWHQ-KEASERVRAEYHLTAKDGDLQSQT 397

Query: 182 VLLNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPACR 337
           +LLN + L+V+ SSG IPAL P+ VNS+EPI V P+SIVFV MP++ +PAC+
Sbjct: 398 MLLNGEALSVN-SSGDIPALTPLHVNSTEPIVVGPFSIVFVHMPFIVLPACK 448


>ref|XP_022845357.1| heparanase-like protein 3 [Olea europaea var. sylvestris]
          Length = 539

 Score =  104 bits (260), Expect = 3e-23
 Identities = 60/110 (54%), Positives = 73/110 (66%)
 Frame = +2

Query: 8   TVQTRVEFQGTLMXXXXXXXXXXXXPKVNPLHQRKQAFGSVREEYHLTPSDGNIQSQTVL 187
           TV  +V+F GTL+             KV  + +  +A    REEYHLT  DGNIQSQT+L
Sbjct: 433 TVDAKVDFNGTLLHRHKHGHHGHRS-KVIKMPRANEA-RKTREEYHLTAMDGNIQSQTML 490

Query: 188 LNRKPLTVDPSSGLIPALEPVRVNSSEPITVAPYSIVFVRMPYVAIPACR 337
           LN K LT+D SSG IP LEP+ V SSE + VAP+SIVFV MPYVA+PAC+
Sbjct: 491 LNGKALTLD-SSGAIPPLEPITVTSSELVKVAPFSIVFVHMPYVALPACK 539