BLASTX 2.2.26 [Sep-21-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Rehmannia31_contig00004502
         (2710 letters)

Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
from WGS projects 
           149,584,005 sequences; 54,822,741,787 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

ref|XP_011093631.1| DNA topoisomerase 1 [Sesamum indicum] >gi|11...  1272   0.0  
gb|PIN13662.1| DNA topoisomerase I [Handroanthus impetiginosus]      1218   0.0  
ref|XP_012845487.1| PREDICTED: DNA topoisomerase 1-like [Erythra...  1056   0.0  
gb|EYU30724.1| hypothetical protein MIMGU_mgv1a001121mg [Erythra...  1056   0.0  
gb|KZV21640.1| DNA topoisomerase 1-like [Dorcoceras hygrometricum]   1048   0.0  
emb|CDP13767.1| unnamed protein product [Coffea canephora]           1008   0.0  
dbj|BAG31376.1| topoisomerase I [Camptotheca acuminata]               994   0.0  
dbj|BAG31377.1| topoisomerase I [Catharanthus roseus]                 978   0.0  
ref|XP_022846035.1| DNA topoisomerase 1 beta-like [Olea europaea...   975   0.0  
dbj|BAK32958.1| topoisomerase I [Ophiorrhiza pedunculata]             975   0.0  
dbj|BAK32962.1| topoisomerase I [Ophiorrhiza trichocarpon var. g...   972   0.0  
dbj|BAK32960.1| topoisomerase I [Ophiorrhiza pseudofasciculata]       969   0.0  
dbj|BAG31375.1| topoisomerase I [Ophiorrhiza japonica]                969   0.0  
ref|XP_010266803.1| PREDICTED: DNA topoisomerase 1 alpha-like [N...   917   0.0  
ref|XP_023553297.1| DNA topoisomerase 1 beta-like [Cucurbita pep...   914   0.0  
gb|KVI01089.1| DNA breaking-rejoining enzyme, catalytic core [Cy...   914   0.0  
ref|XP_023007686.1| DNA topoisomerase 1 beta-like [Cucurbita max...   907   0.0  
ref|XP_022932254.1| DNA topoisomerase 1 beta-like [Cucurbita mos...   905   0.0  
gb|PON81509.1| DNA topoisomerase I [Trema orientalis]                 894   0.0  
gb|PNT12575.1| hypothetical protein POPTR_011G092700v3 [Populus ...   863   0.0  

>ref|XP_011093631.1| DNA topoisomerase 1 [Sesamum indicum]
 ref|XP_020553411.1| DNA topoisomerase 1 [Sesamum indicum]
          Length = 893

 Score = 1272 bits (3292), Expect = 0.0
 Identities = 641/813 (78%), Positives = 676/813 (83%)
 Frame = +3

Query: 249  MAVEACDKQKLXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDVR 428
            MA+E+C+ QKL         PLVFKR            E K+ LSQKHDR L RP+PDVR
Sbjct: 1    MAIESCNDQKLMDDMDEDDEPLVFKRSSSSAKQSQGNSETKRPLSQKHDRPLNRPSPDVR 60

Query: 429  SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 608
             QNGQST+++KSKTVP S+TPP++ PL SPKSSN+S KALA++  EVD +PSTSVTD+SN
Sbjct: 61   PQNGQSTMIQKSKTVPSSRTPPLRSPLASPKSSNSSAKALAVRPREVDPRPSTSVTDESN 120

Query: 609  SVKHQIKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTSTLSQK 788
            SVKHQIKDEK ST+ATG  NEDS+DSEDDKPLSARLPAGLSKVNSNHA K PN  T  QK
Sbjct: 121  SVKHQIKDEKPSTKATGGLNEDSEDSEDDKPLSARLPAGLSKVNSNHANKGPNALTSVQK 180

Query: 789  RRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTERKPSTN 968
             +IP PEDSDDEIPLSSKFQVKSNAGES NR S SGERKPLL+KYDQNGSAS ERKPST 
Sbjct: 181  TKIPKPEDSDDEIPLSSKFQVKSNAGESTNRPSISGERKPLLAKYDQNGSASAERKPSTI 240

Query: 969  LKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDEDHVPISHRMXXXXX 1148
            LKKRP DGVK+  ESYLKKPKLS+A+TP+K KE SIK EM++EDDEDHVPIS R+     
Sbjct: 241  LKKRPADGVKSAGESYLKKPKLSDASTPNKTKETSIKDEMKDEDDEDHVPISQRIKQQTS 300

Query: 1149 XXXXXXXXXNITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGEGQKWTTLVHNGVI 1328
                     N+TKPI                              GEGQKWTTLVHNGVI
Sbjct: 301  SDKKSSSAKNMTKPISASAKKTSKKPKKVMKNSKYSKSSKVPPSSGEGQKWTTLVHNGVI 360

Query: 1329 FPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKPKFKENFMADWRKILGK 1508
            FPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVML+TDYMNKPKFKENFMADWRKILGK
Sbjct: 361  FPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLDTDYMNKPKFKENFMADWRKILGK 420

Query: 1509 NHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXXXXXYMWAIVNGVKEKV 1688
            NH IQSLEHCDFTPIYEWH                            YMWAIVNGVKEKV
Sbjct: 421  NHVIQSLEHCDFTPIYEWHQKEKEKKKQMTAEEKKALKEEKLKQEEKYMWAIVNGVKEKV 480

Query: 1689 GNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWKEIRHDNT 1868
            GNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWKEIRHDNT
Sbjct: 481  GNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWKEIRHDNT 540

Query: 1869 VTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYILGIRAAYTKDFTSK 2048
            VTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYI GIRAAYTKDFT+K
Sbjct: 541  VTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYIHGIRAAYTKDFTNK 600

Query: 2049 DPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNTLKFDFLGKDS 2228
            DP K+QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPN LKFDFLGKDS
Sbjct: 601  DPTKKQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNILKFDFLGKDS 660

Query: 2229 IRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNA 2408
            IRYQNEVEVET VFKAIQQFRSGKKG DD+FDRLDTSKLNAHLKELMPGLTAKVFRTYNA
Sbjct: 661  IRYQNEVEVETPVFKAIQQFRSGKKGSDDMFDRLDTSKLNAHLKELMPGLTAKVFRTYNA 720

Query: 2409 SITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMLRLNEKIEELK 2588
            SITLDD LSRET+GGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQM RLNEKIEELK
Sbjct: 721  SITLDDKLSRETKGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMTRLNEKIEELK 780

Query: 2589 GVVEELQTDLARAKKGKPPLKSADGKPKRNMNP 2687
            GV+EELQTDLARAKKGKPPLKSADGKPKRN+NP
Sbjct: 781  GVLEELQTDLARAKKGKPPLKSADGKPKRNLNP 813


>gb|PIN13662.1| DNA topoisomerase I [Handroanthus impetiginosus]
          Length = 895

 Score = 1218 bits (3151), Expect = 0.0
 Identities = 616/815 (75%), Positives = 663/815 (81%), Gaps = 2/815 (0%)
 Frame = +3

Query: 249  MAVEACDKQKLXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDVR 428
            MAVEACDKQKL         PLVFKR            E KKSLSQKHDRQLG+PAPD+R
Sbjct: 1    MAVEACDKQKLMDDMDDDDEPLVFKRSSSAAKQNQSVSETKKSLSQKHDRQLGKPAPDIR 60

Query: 429  SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 608
            SQNGQST+V+KSK    SKTPPV+ PL SPKSSN+S K+ A+KS  V+SKPSTSV D+SN
Sbjct: 61   SQNGQSTMVEKSKMASSSKTPPVRSPLASPKSSNSSAKSFAVKSSGVNSKPSTSVADESN 120

Query: 609  SVKHQIKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTSTLSQK 788
            SVK Q +D++  TEAT E NE+S+DS+DDKPL+ARL AG SK+NSNHA K PN S L QK
Sbjct: 121  SVKQQSRDKRPLTEATAELNEESEDSDDDKPLTARLSAGFSKINSNHANKGPNASILGQK 180

Query: 789  RRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTERKPSTN 968
             +IP  EDSDDEIPLSSKFQVKSNAG+S  +S  SG RKPL +K D NG  S ERKPS++
Sbjct: 181  PKIPKSEDSDDEIPLSSKFQVKSNAGDSSKKSPTSGGRKPLSAKCDHNGLGSPERKPSSS 240

Query: 969  --LKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDEDHVPISHRMXXX 1142
              LKKRP DGVK+  ES+LK+PKLS+A+  +KNKE SIKAE++EEDDEDHVPIS RM   
Sbjct: 241  TILKKRPADGVKSAGESHLKRPKLSDASASNKNKETSIKAELKEEDDEDHVPISARMKKS 300

Query: 1143 XXXXXXXXXXXNITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGEGQKWTTLVHNG 1322
                       NITKP+                              GEGQKWTTLVHNG
Sbjct: 301  TSSDKKPSSSKNITKPVSSLSKKINKKSKKVTKKSEYSKSSKVPPGSGEGQKWTTLVHNG 360

Query: 1323 VIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKPKFKENFMADWRKIL 1502
            VIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATM+AVML+TDYMNKPKFKENFM DWRKIL
Sbjct: 361  VIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMNKPKFKENFMDDWRKIL 420

Query: 1503 GKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXXXXXYMWAIVNGVKE 1682
            GKNH IQSLEHC+FTPIYEWH                            YMWAIV+GVKE
Sbjct: 421  GKNHVIQSLEHCNFTPIYEWHQKEKEKKKQMSADEKKALKEEKLKQEDKYMWAIVDGVKE 480

Query: 1683 KVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWKEIRHD 1862
            KVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDI INIGKDAPIPECPIPGESWKE+RHD
Sbjct: 481  KVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDIVINIGKDAPIPECPIPGESWKEVRHD 540

Query: 1863 NTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYILGIRAAYTKDFT 2042
            NTVTWLAYWNDPINPKEFKYVFLAASS LKGQSDKEKYEKARLLKDYI  IRA YTK+FT
Sbjct: 541  NTVTWLAYWNDPINPKEFKYVFLAASSALKGQSDKEKYEKARLLKDYIQDIRATYTKNFT 600

Query: 2043 SKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNTLKFDFLGK 2222
            SKDP K+QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPN LKFDFLGK
Sbjct: 601  SKDPTKKQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNILKFDFLGK 660

Query: 2223 DSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLKELMPGLTAKVFRTY 2402
            DSIRYQNEVEVETAVF+AIQ+FR GKKGGDDLFD+LDTSKLNAHLKELMPGLTAKVFRTY
Sbjct: 661  DSIRYQNEVEVETAVFRAIQEFRRGKKGGDDLFDKLDTSKLNAHLKELMPGLTAKVFRTY 720

Query: 2403 NASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMLRLNEKIEE 2582
            NASITLDDMLSRET+GGDVAEKVVVYQ ANKEVAIICNHQRTVSKSHSAQMLRLNEKIEE
Sbjct: 721  NASITLDDMLSRETKGGDVAEKVVVYQLANKEVAIICNHQRTVSKSHSAQMLRLNEKIEE 780

Query: 2583 LKGVVEELQTDLARAKKGKPPLKSADGKPKRNMNP 2687
            LKGV+EELQTDLARAKKGKPPLK+ADGKPKRN+NP
Sbjct: 781  LKGVLEELQTDLARAKKGKPPLKNADGKPKRNLNP 815


>ref|XP_012845487.1| PREDICTED: DNA topoisomerase 1-like [Erythranthe guttata]
          Length = 894

 Score = 1056 bits (2732), Expect = 0.0
 Identities = 559/829 (67%), Positives = 621/829 (74%), Gaps = 16/829 (1%)
 Frame = +3

Query: 249  MAVEAC-DKQKLXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDV 425
            M VEA  DK  +         PLVFKR            E K S SQKH+ Q+GR + DV
Sbjct: 1    MTVEAREDKNMMEDMDDDDDAPLVFKRSGSSSKPKQSEPENKLS-SQKHNAQVGRQSSDV 59

Query: 426  RSQNGQSTIVKKSKTVPLSKT--PPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTD 599
            R QNG +   +K K+V  S +  PPV+  L SPKSSN+S KA  +KSP+V+SKPSTSV  
Sbjct: 60   RPQNGTNANAQKGKSVTSSSSMKPPVRPSLVSPKSSNSSVKASPIKSPDVNSKPSTSVVG 119

Query: 600  KSNSVKHQIKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTSTL 779
            +S SVK  IK+E            +S+DSEDDKPLSAR  AG SK N N   K PN   L
Sbjct: 120  ESKSVKSTIKEE------------NSEDSEDDKPLSARQVAGSSKNNPNQTNK-PNAPNL 166

Query: 780  SQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLS-KYDQNGSASTERK 956
             +K  +P PEDSDDEIPLS+KFQ KSNAG S +RSS+S E+KPL++ K D+NGSASTERK
Sbjct: 167  GKKSNVPKPEDSDDEIPLSAKFQGKSNAGASTSRSSHSEEKKPLVARKPDKNGSASTERK 226

Query: 957  PSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDEDHVPISHRMX 1136
            PST L+KRP DGV +  +S LKKPKLS++    K+K+AS+K E++ EDDED VP+S R  
Sbjct: 227  PSTVLQKRPADGVASAGQSNLKKPKLSDSLAS-KDKKASVKPEVKAEDDEDLVPLSQRTK 285

Query: 1137 XXXXXXXXXXXXXNITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX----------- 1283
                          +TK                                           
Sbjct: 286  KSTTPEKKPSPALKVTKSTASISKKTNNKTNSKTNSKTNKKSKQVSKDNNYSKSSKLPPS 345

Query: 1284 -GEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKP 1460
             G+GQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPV+LTPEQEEVATMYAVMLETDY+ KP
Sbjct: 346  SGDGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVNLTPEQEEVATMYAVMLETDYLKKP 405

Query: 1461 KFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXX 1640
            +FKENFM DW+KILGKNH IQSLEHCDFTPIYEWH                         
Sbjct: 406  QFKENFMTDWKKILGKNHVIQSLEHCDFTPIYEWHQREKEKKKQMSTDEKKALKEEKLKL 465

Query: 1641 XXXYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPE 1820
               YMWA+++GV+EKVGNFRVEPPGLFRGRGEHPKMGKLK+RIRPSDITINIG+DAPIPE
Sbjct: 466  EEKYMWAVLDGVREKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDITINIGRDAPIPE 525

Query: 1821 CPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKD 2000
            CPI GE WKEIRHDNTVTWLAYW+DPIN KEFKYVFLAASSTLKGQSDKEKYEKARLLKD
Sbjct: 526  CPIEGERWKEIRHDNTVTWLAYWSDPINGKEFKYVFLAASSTLKGQSDKEKYEKARLLKD 585

Query: 2001 YILGIRAAYTKDFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVE 2180
            YI GIR AYT+DF SKDPAK+QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVE
Sbjct: 586  YIQGIRTAYTRDFVSKDPAKKQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVE 645

Query: 2181 PVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLK 2360
            PVPPN LKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFD+LDTSKLNAHLK
Sbjct: 646  PVPPNILKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDKLDTSKLNAHLK 705

Query: 2361 ELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKS 2540
            ELMPGLTAKVFRTYNASITLDD LSRET+GGD+AEKVV Y HANKEVAIICNHQRTVSK+
Sbjct: 706  ELMPGLTAKVFRTYNASITLDDKLSRETKGGDLAEKVVTYNHANKEVAIICNHQRTVSKT 765

Query: 2541 HSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNMNP 2687
            HSAQMLRL+EKI+ELKGV+EEL+TDL RA+KGKP L  ADGK KRN+NP
Sbjct: 766  HSAQMLRLDEKIDELKGVLEELKTDLGRARKGKPLLAGADGKAKRNINP 814


>gb|EYU30724.1| hypothetical protein MIMGU_mgv1a001121mg [Erythranthe guttata]
          Length = 883

 Score = 1056 bits (2732), Expect = 0.0
 Identities = 558/818 (68%), Positives = 619/818 (75%), Gaps = 5/818 (0%)
 Frame = +3

Query: 249  MAVEAC-DKQKLXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDV 425
            M VEA  DK  +         PLVFKR            E K S SQKH+ Q+GR + DV
Sbjct: 1    MTVEAREDKNMMEDMDDDDDAPLVFKRSGSSSKPKQSEPENKLS-SQKHNAQVGRQSSDV 59

Query: 426  RSQNGQSTIVKKSKTVPLSKT--PPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTD 599
            R QNG +   +K K+V  S +  PPV+  L SPKSSN+S KA  +KSP+V+SKPSTSV  
Sbjct: 60   RPQNGTNANAQKGKSVTSSSSMKPPVRPSLVSPKSSNSSVKASPIKSPDVNSKPSTSVVG 119

Query: 600  KSNSVKHQIKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTSTL 779
            +S SVK  IK+E            +S+DSEDDKPLSAR  AG SK N N   K PN   L
Sbjct: 120  ESKSVKSTIKEE------------NSEDSEDDKPLSARQVAGSSKNNPNQTNK-PNAPNL 166

Query: 780  SQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLS-KYDQNGSASTERK 956
             +K  +P PEDSDDEIPLS+KFQ KSNAG S +RSS+S E+KPL++ K D+NGSASTERK
Sbjct: 167  GKKSNVPKPEDSDDEIPLSAKFQGKSNAGASTSRSSHSEEKKPLVARKPDKNGSASTERK 226

Query: 957  PSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDEDHVPISHRMX 1136
            PST L+KRP DGV +  +S LKKPKLS++    K+K+AS+K E++ EDDED VP+S R  
Sbjct: 227  PSTVLQKRPADGVASAGQSNLKKPKLSDSLAS-KDKKASVKPEVKAEDDEDLVPLSQRTK 285

Query: 1137 XXXXXXXXXXXXXNIT-KPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGEGQKWTTLV 1313
                             K                                G+GQKWTTLV
Sbjct: 286  KSTTPEKKPSPALKTNNKTNSKTNSKTNKKSKQVSKDNNYSKSSKLPPSSGDGQKWTTLV 345

Query: 1314 HNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKPKFKENFMADWR 1493
            HNGVIFPPPYKPHGVKMLYKGKPV+LTPEQEEVATMYAVMLETDY+ KP+FKENFM DW+
Sbjct: 346  HNGVIFPPPYKPHGVKMLYKGKPVNLTPEQEEVATMYAVMLETDYLKKPQFKENFMTDWK 405

Query: 1494 KILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXXXXXYMWAIVNG 1673
            KILGKNH IQSLEHCDFTPIYEWH                            YMWA+++G
Sbjct: 406  KILGKNHVIQSLEHCDFTPIYEWHQREKEKKKQMSTDEKKALKEEKLKLEEKYMWAVLDG 465

Query: 1674 VKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWKEI 1853
            V+EKVGNFRVEPPGLFRGRGEHPKMGKLK+RIRPSDITINIG+DAPIPECPI GE WKEI
Sbjct: 466  VREKVGNFRVEPPGLFRGRGEHPKMGKLKRRIRPSDITINIGRDAPIPECPIEGERWKEI 525

Query: 1854 RHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYILGIRAAYTK 2033
            RHDNTVTWLAYW+DPIN KEFKYVFLAASSTLKGQSDKEKYEKARLLKDYI GIR AYT+
Sbjct: 526  RHDNTVTWLAYWSDPINGKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYIQGIRTAYTR 585

Query: 2034 DFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNTLKFDF 2213
            DF SKDPAK+QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPN LKFDF
Sbjct: 586  DFVSKDPAKKQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNILKFDF 645

Query: 2214 LGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLKELMPGLTAKVF 2393
            LGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFD+LDTSKLNAHLKELMPGLTAKVF
Sbjct: 646  LGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDKLDTSKLNAHLKELMPGLTAKVF 705

Query: 2394 RTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMLRLNEK 2573
            RTYNASITLDD LSRET+GGD+AEKVV Y HANKEVAIICNHQRTVSK+HSAQMLRL+EK
Sbjct: 706  RTYNASITLDDKLSRETKGGDLAEKVVTYNHANKEVAIICNHQRTVSKTHSAQMLRLDEK 765

Query: 2574 IEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNMNP 2687
            I+ELKGV+EEL+TDL RA+KGKP L  ADGK KRN+NP
Sbjct: 766  IDELKGVLEELKTDLGRARKGKPLLAGADGKAKRNINP 803


>gb|KZV21640.1| DNA topoisomerase 1-like [Dorcoceras hygrometricum]
          Length = 870

 Score = 1048 bits (2709), Expect = 0.0
 Identities = 556/818 (67%), Positives = 619/818 (75%), Gaps = 5/818 (0%)
 Frame = +3

Query: 249  MAVEACDKQK-LXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDV 425
            MAV+A D++K L         PLVFKR                S S KH+ + G+     
Sbjct: 1    MAVDAFDEKKSLDDVDDDDDQPLVFKR---------------SSSSSKHNLKNGQ----- 40

Query: 426  RSQNGQSTIVKKSKTVP-LSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDK 602
            +S+NG+S+ V+K   VP  SK PP+K PLTSPKSS+++ K   +KS   +SK   S TDK
Sbjct: 41   QSRNGESSSVQKGTLVPPSSKAPPIKSPLTSPKSSSSAAKESPVKSSAANSKRPMSETDK 100

Query: 603  SNSVKHQIKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTSTLS 782
             NSVK Q+K+E+   +A  E + D +DS DD PLSARL A  SK NSNHAK+ PN   L 
Sbjct: 101  PNSVKQQVKEEQPFAQAADETH-DLEDSGDDTPLSARLLASSSKGNSNHAKQRPNALALV 159

Query: 783  QKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE---R 953
            QK  IP  EDSDDE+PLSSKFQVKS+   S +RS+NS ERKP+L+K DQNGS+ST+   +
Sbjct: 160  QKNSIPKKEDSDDEMPLSSKFQVKSDVRVSTSRSNNSDERKPILNKADQNGSSSTDHSQK 219

Query: 954  KPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDEDHVPISHRM 1133
            KPS  +K RP + VK    S  KKPKLS A++      A  +A+ + EDD+DHVPIS RM
Sbjct: 220  KPSIAMK-RPPNPVKVECRSPEKKPKLSNASS------AIPRAKPKAEDDDDHVPISQRM 272

Query: 1134 XXXXXXXXXXXXXXNITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGEGQKWTTLV 1313
                           +TK +                              GEGQKWTTLV
Sbjct: 273  KNQSSSEKKSLSVKKVTKSVSAVATKTNKISKKIVKNTKYSISSKVLPNSGEGQKWTTLV 332

Query: 1314 HNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKPKFKENFMADWR 1493
            HNGVIFPPPYKPHGVKMLYKGKPV LTPEQEEVATM+AVML+TDYMNKPKFKENFM DWR
Sbjct: 333  HNGVIFPPPYKPHGVKMLYKGKPVVLTPEQEEVATMFAVMLDTDYMNKPKFKENFMTDWR 392

Query: 1494 KILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXXXXXYMWAIVNG 1673
            KILGKNHTIQ LE CDFTPIYEWH                            YMWAI++G
Sbjct: 393  KILGKNHTIQKLEDCDFTPIYEWHQKEKEKKKQMSTEEKKALKEEKLKQEEKYMWAILDG 452

Query: 1674 VKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWKEI 1853
            VKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRI+PSDI INIGKDA IPECPIPGESWKEI
Sbjct: 453  VKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIQPSDIIINIGKDAAIPECPIPGESWKEI 512

Query: 1854 RHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYILGIRAAYTK 2033
            RHDNTVTWLAYWNDPIN KEFKYVFLAASSTLKGQSDKEKYEKARLLK+YI GIRAAYTK
Sbjct: 513  RHDNTVTWLAYWNDPINQKEFKYVFLAASSTLKGQSDKEKYEKARLLKNYIQGIRAAYTK 572

Query: 2034 DFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNTLKFDF 2213
            DF+SKDP ++QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPN LKFDF
Sbjct: 573  DFSSKDPTRKQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNILKFDF 632

Query: 2214 LGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLKELMPGLTAKVF 2393
            LGKDSIRYQNEV VETAVFKAIQQFR+GKKGGDDLFD+LDTSKLNAHLKELMPGLTAKVF
Sbjct: 633  LGKDSIRYQNEVVVETAVFKAIQQFRNGKKGGDDLFDKLDTSKLNAHLKELMPGLTAKVF 692

Query: 2394 RTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMLRLNEK 2573
            RTYNASITLDDML+RET+GG+VAEK+VVYQHANKEVAIICNHQRTVSKSHSAQMLRL+EK
Sbjct: 693  RTYNASITLDDMLNRETKGGEVAEKIVVYQHANKEVAIICNHQRTVSKSHSAQMLRLDEK 752

Query: 2574 IEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNMNP 2687
            I+ELKG +EEL+ DL+RAKKGKPPLKSADGKPKRNMNP
Sbjct: 753  IDELKGAMEELREDLSRAKKGKPPLKSADGKPKRNMNP 790


>emb|CDP13767.1| unnamed protein product [Coffea canephora]
          Length = 926

 Score = 1008 bits (2607), Expect = 0.0
 Identities = 532/847 (62%), Positives = 600/847 (70%), Gaps = 34/847 (4%)
 Frame = +3

Query: 249  MAVEACDKQKLXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDVR 428
            MAVEAC    L         PLVFKR            E KK  SQK D Q  R + DV 
Sbjct: 1    MAVEACSTPSLLEDSDEENAPLVFKRTSSSSKQNLSNSETKKLSSQKRDGQSSRNSSDVC 60

Query: 429  SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 608
              NGQS+  +  + V  +KTPP K PL+SPK++N S K   + SP  +SKPS+S +    
Sbjct: 61   PVNGQSSSAQTGRVVSSAKTPPAKSPLSSPKAANISAKTSLITSPGANSKPSSSTSATVK 120

Query: 609  SVKHQ-----IKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTS 773
             +++      +K  K S  A  + +   +DS+DDKPL A+LP+G S+   NH  K  + S
Sbjct: 121  QLENHKNSPVVKLPKRSVSAA-KLSSTPEDSDDDKPLMAKLPSGSSRAIVNHGNKDGDGS 179

Query: 774  TLSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTER 953
            +L QK  +   EDSDDE PLSS++  KSN  ESI++S N GE+K L +K  QNGSA  + 
Sbjct: 180  SLVQKPGVEEDEDSDDEKPLSSRYLSKSNLVESISKSRNPGEKKSLPAKVQQNGSALRDG 239

Query: 954  ---KPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDED----- 1109
               K S+   KRP   VK++DES +KKPKLS        K+A++KAE + EDD+D     
Sbjct: 240  PVGKSSSLSNKRPPGEVKSSDESAVKKPKLSGPTAAINKKQATLKAEPKVEDDDDDILIS 299

Query: 1110 ---------------------HVPISHRMXXXXXXXXXXXXXXNITKPIXXXXXXXXXXX 1226
                                 HVPI+ RM               + K +           
Sbjct: 300  QTAKKMFASASKPKSNDDDDDHVPITQRMKKSTTSVSQSSSVKKVAKVVSSSLKKTNKKS 359

Query: 1227 XXXXXXXXXXXXXXXXXXXGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQE 1406
                               GEGQKWTTLVHNGVIFPPPYKPHGVKMLYKG+PV LTPEQE
Sbjct: 360  KKIIKKSKYSKSSKVPPGSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGQPVTLTPEQE 419

Query: 1407 EVATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXX 1586
            EVATM+AVML+TDYM+KP+FKENF +DW++ILGKNHTIQ+LE CDF PIYEWH       
Sbjct: 420  EVATMFAVMLDTDYMSKPQFKENFFSDWKRILGKNHTIQNLEDCDFRPIYEWHQKEKEKK 479

Query: 1587 XXXXXXXXXXXXXXXXXXXXXYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKR 1766
                                 YMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKR
Sbjct: 480  KQMTTEEKKSLKEEKLKQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKR 539

Query: 1767 IRPSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASST 1946
            IRP DITINIGKDAPIPECPIPGE WKEIRHDNTVTWLA+WNDPINPKEFKYVFLAASST
Sbjct: 540  IRPRDITINIGKDAPIPECPIPGERWKEIRHDNTVTWLAFWNDPINPKEFKYVFLAASST 599

Query: 1947 LKGQSDKEKYEKARLLKDYILGIRAAYTKDFTSKDPAKRQIAVATYLIDKLALRAGNEKD 2126
            LKGQSDKEKYEKARLLKDYI GIR AYTKDF SKDP K+QIAVATYLIDKLALRAGNEKD
Sbjct: 600  LKGQSDKEKYEKARLLKDYIHGIRTAYTKDFASKDPMKKQIAVATYLIDKLALRAGNEKD 659

Query: 2127 DDEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKG 2306
            DDEADTVGCCTLKVENVEPVPPN LKFDFLGKDSIRYQNEVEVE+ VFKAIQQFRSGK+G
Sbjct: 660  DDEADTVGCCTLKVENVEPVPPNILKFDFLGKDSIRYQNEVEVESGVFKAIQQFRSGKEG 719

Query: 2307 GDDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQH 2486
             +DLFD+LDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSR+T GGDV EKVVVYQ 
Sbjct: 720  SEDLFDKLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRKTNGGDVLEKVVVYQQ 779

Query: 2487 ANKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGK 2666
            ANKEVAIICNHQRTVSK+HSAQM RLNEKIEELKGV+EEL+TDL+RAKKGKPPLK+ADGK
Sbjct: 780  ANKEVAIICNHQRTVSKTHSAQMSRLNEKIEELKGVLEELKTDLSRAKKGKPPLKNADGK 839

Query: 2667 PKRNMNP 2687
            PKRN+NP
Sbjct: 840  PKRNLNP 846


>dbj|BAG31376.1| topoisomerase I [Camptotheca acuminata]
          Length = 894

 Score =  994 bits (2571), Expect = 0.0
 Identities = 528/823 (64%), Positives = 599/823 (72%), Gaps = 10/823 (1%)
 Frame = +3

Query: 249  MAVEACDKQKLXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDVR 428
            MAV+AC K+K+         PLVFKR            + KKS SQ++D Q GR   DV 
Sbjct: 1    MAVQACVKEKMMDEIDEDDEPLVFKRSNATSKHNQLNSDTKKS-SQRYDGQSGRQVSDVP 59

Query: 429  SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 608
            S NGQS+   K KT  LS    +K P+ SPK+S +  KA  + +P+V S  S+    K +
Sbjct: 60   STNGQSSSASKGKTTKLSS---MKSPIASPKASTSFAKASPVANPKVSS--SSDDRSKHS 114

Query: 609  SVKHQIKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTSTLSQK 788
            S ++ I   K   E      E   DSED+KPLSARL  GL+K +SN+A K    S+ +  
Sbjct: 115  SKQNTINVVKEEKELVNPAAEPYGDSEDEKPLSARLFTGLTKGSSNNANKGLINSSPAS- 173

Query: 789  RRIPIP--------EDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSAS 944
              +P+P        +DSDDEIPLSSKF++K+NAG S  +S  S + K L+S + QNGS +
Sbjct: 174  --LPVPKPEINRYSDDSDDEIPLSSKFRLKANAGTSTVKSYESDDNKTLVSNFQQNGSIN 231

Query: 945  TERKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREED-DEDHVPI 1121
               K S  + KRP   VK++ +S +KKPKLS+A+TP  NK+AS KAE + +D D+DHVPI
Sbjct: 232  RGSKSSIKVNKRPLGEVKSSVQSSVKKPKLSDASTPVNNKQASKKAEPKADDSDDDHVPI 291

Query: 1122 SHRMXXXXXXXXXXXXXXN-ITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGEGQK 1298
            S RM                +TK +                              GEG+K
Sbjct: 292  SQRMKKSATSGNKSSTAKQKVTKVVSSSMKKASKKFKKVVKKSKYSKSSKVPPSSGEGKK 351

Query: 1299 WTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKPKFKENF 1478
            W TLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATM+AVML+TDYM K KFKENF
Sbjct: 352  WNTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMFAVMLDTDYMTKSKFKENF 411

Query: 1479 MADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXXXXXYMW 1658
            M DWRKILGKNH IQ+LE CDFTPIYEWH                            YMW
Sbjct: 412  MDDWRKILGKNHVIQNLEDCDFTPIYEWHQREKEKKKKMTAEEKKVLKEERLKQEEKYMW 471

Query: 1659 AIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGE 1838
            AIVNGVKEKVGNFRVEPP LFRGRGEHPKMGKLKK IRPSDITINIGKDAPIPECPIPGE
Sbjct: 472  AIVNGVKEKVGNFRVEPPSLFRGRGEHPKMGKLKKCIRPSDITINIGKDAPIPECPIPGE 531

Query: 1839 SWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYILGIR 2018
            SWKEIRHDNTVTWLA+WNDPI P+EFKYVFLAASS+LKGQSDKEKYEKARLLKD+I GIR
Sbjct: 532  SWKEIRHDNTVTWLAFWNDPIKPREFKYVFLAASSSLKGQSDKEKYEKARLLKDFIQGIR 591

Query: 2019 AAYTKDFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNT 2198
            AAYTKDF SKD  KRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEP PP+ 
Sbjct: 592  AAYTKDFASKDITKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPKPPSI 651

Query: 2199 LKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLKELMPGL 2378
            LKFDFLGKDSIRYQNEVEVE  V+KAIQQFR+GK+GGDDLFD+LDTSKLNAHLK LMPGL
Sbjct: 652  LKFDFLGKDSIRYQNEVEVELPVYKAIQQFRTGKRGGDDLFDKLDTSKLNAHLKGLMPGL 711

Query: 2379 TAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQML 2558
            TAKVFRTYNASITLD+MLSRET+GG+VAEK+VVYQHANKEVAIICNHQRTVSKSH AQM 
Sbjct: 712  TAKVFRTYNASITLDEMLSRETKGGNVAEKIVVYQHANKEVAIICNHQRTVSKSHPAQMT 771

Query: 2559 RLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNMNP 2687
            RLN KI+ELKG+++ LQTDLARAKKGKPPL+ ADGKPKRN+ P
Sbjct: 772  RLNGKIDELKGILDGLQTDLARAKKGKPPLEDADGKPKRNLTP 814


>dbj|BAG31377.1| topoisomerase I [Catharanthus roseus]
          Length = 910

 Score =  978 bits (2529), Expect = 0.0
 Identities = 525/839 (62%), Positives = 585/839 (69%), Gaps = 26/839 (3%)
 Frame = +3

Query: 249  MAVEACDKQKLXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDVR 428
            MAVEAC    L         P+VFKR            E +K  SQK D Q  R   D R
Sbjct: 1    MAVEACPTPNLRDDMDEDDEPIVFKRNNSASKQSQTNSETRKVSSQKRDGQSVRQIYDSR 60

Query: 429  SQNGQSTIVKKSKTVPLSK---------TPP-----VKYPLTSPKSSNTSGKALALKSPE 566
              NG+S+  +K + VP SK         +PP     VK PL+SPK S +S K   + S  
Sbjct: 61   PANGESSSGQKGRMVPPSKPSQVKSPLSSPPSKPSQVKSPLSSPKVSTSSAKKSPVSSLP 120

Query: 567  VDSKPSTSVTDKSNSVKHQ-----IKDEKLST-EATGEPNEDSQDSEDDKPLSARLPAGL 728
             +SKPSTS + K            IK+EK S          DS+DS+D KPLS R  A  
Sbjct: 121  ANSKPSTSGSFKVKPFNQHKSATVIKEEKSSPLRLASAIINDSEDSDDGKPLSLRHSASS 180

Query: 729  SKVNSNHAKKSPNTSTLSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKP 908
            SK N+N   K  +          P  EDSDDE PLSS+F +KS  GES +++ +S + KP
Sbjct: 181  SKGNTNQVSKEGSK---------PENEDSDDEKPLSSRFPLKSGVGESTSKAYDSDDDKP 231

Query: 909  LLSKYDQNGSASTERKP---STNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIK 1079
            L  K   NGSA  + +P   S    KRP   +K++++  +KKPKLS    P   K+AS+K
Sbjct: 232  LAKKLQHNGSAMRDGQPNKYSNMSNKRPPGDIKSSNQLSVKKPKLSSVTAPTNKKQASVK 291

Query: 1080 AEMR-EEDDEDHVPISHRMXXXXXXXXXXXXXXNITKPIXXXXXXXXXXXXXXXXXXXXX 1256
             E + E+DD+DH+PIS R+                TK +                     
Sbjct: 292  PEPKAEDDDDDHLPISQRIKKSPTSESKSSSIKKTTKVVSSSVKKVNKKSKKVMKNSKYS 351

Query: 1257 XXXXXXXXXGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVML 1436
                     GEG+KW  L HNGVIFPPPYKPHG+KMLYKGKPVDLTPEQEEVATM+AVML
Sbjct: 352  KSSKVPPSSGEGKKWNKLEHNGVIFPPPYKPHGIKMLYKGKPVDLTPEQEEVATMFAVML 411

Query: 1437 ETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXX 1616
            +TDYMNKP+FKENF  DW+KILGKNH IQ+LE+CDF+PIYEWH                 
Sbjct: 412  DTDYMNKPRFKENFFGDWKKILGKNHVIQNLENCDFSPIYEWHQSEKEKKKQMTTEEKKA 471

Query: 1617 XXXXXXXXXXXYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINI 1796
                       YMWA V+G KEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRP DITINI
Sbjct: 472  LKEEKLKQEEKYMWAWVDGKKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPCDITINI 531

Query: 1797 GKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKY 1976
            GKDAPIPECP+PGE WKE+RHDNTVTWLA+WNDPINPKEFKYVFLAASSTLKG SDKEKY
Sbjct: 532  GKDAPIPECPVPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSTLKGLSDKEKY 591

Query: 1977 EKARLLKDYILGIRAAYTKDFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCC 2156
            EKARLLKDYI GIRAAYTKDF SKDP K+QIAVATYLIDKLALRAGNEKDDDEADTVGCC
Sbjct: 592  EKARLLKDYIQGIRAAYTKDFASKDPTKKQIAVATYLIDKLALRAGNEKDDDEADTVGCC 651

Query: 2157 TLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDT 2336
            TLKVENVEPVPPN LKFDFLGKDSIRYQNEVEVE AVFKAIQQFRSGK+G  DLFD LDT
Sbjct: 652  TLKVENVEPVPPNILKFDFLGKDSIRYQNEVEVEAAVFKAIQQFRSGKEGSSDLFDLLDT 711

Query: 2337 SKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICN 2516
            SKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRET+GGDVAEKVVVYQHANKEVAIICN
Sbjct: 712  SKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETKGGDVAEKVVVYQHANKEVAIICN 771

Query: 2517 HQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKS--ADGKPKRNMNP 2687
            HQRTVSKSHSAQMLRLNEKIEELK VVEEL++DL+R KKGKPPLKS  ADGKPKRN+NP
Sbjct: 772  HQRTVSKSHSAQMLRLNEKIEELKAVVEELKSDLSRVKKGKPPLKSKNADGKPKRNLNP 830


>ref|XP_022846035.1| DNA topoisomerase 1 beta-like [Olea europaea var. sylvestris]
          Length = 771

 Score =  975 bits (2520), Expect = 0.0
 Identities = 497/692 (71%), Positives = 544/692 (78%), Gaps = 4/692 (0%)
 Frame = +3

Query: 624  IKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTSTLSQKRRIPI 803
            +K EK ST    EPN DS+DSEDDKPLSARL   LSK NSN+A K  N S L QK  IP 
Sbjct: 1    MKVEKPSTGPAAEPN-DSEDSEDDKPLSARLSTSLSKNNSNNASKGSNASRLGQKPSIPK 59

Query: 804  PEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSA---STERKPSTNLK 974
             EDSDDE PLS K Q+KSN G S  +S +S E+  L +K +QNGS    S  +KPST L 
Sbjct: 60   QEDSDDEKPLSHKVQLKSNVGSSTRKSYDSDEKMHLAAKNNQNGSPLQDSGSKKPSTILS 119

Query: 975  KRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMR-EEDDEDHVPISHRMXXXXXX 1151
            KRP   V +  +S +KK K+S A+    NK+AS+KAE + E+DD+DH+PIS RM      
Sbjct: 120  KRPASEVNSAGQSSIKKHKISNASVLINNKQASVKAEPKVEDDDDDHIPISQRMKKPAAS 179

Query: 1152 XXXXXXXXNITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGEGQKWTTLVHNGVIF 1331
                     +TK +                              GEGQKWTTL+HNGVIF
Sbjct: 180  DKKISAIKKVTKVVSSSLNKTNKNSKKVVKKSQYSKSSKVPPGSGEGQKWTTLIHNGVIF 239

Query: 1332 PPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKPKFKENFMADWRKILGKN 1511
            PPPY+ HGVKMLYKGKPV+LTPEQEEVATM+AVML+T+YMNKPKFKENFM+DWRKILGKN
Sbjct: 240  PPPYQSHGVKMLYKGKPVNLTPEQEEVATMFAVMLDTEYMNKPKFKENFMSDWRKILGKN 299

Query: 1512 HTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXXXXXYMWAIVNGVKEKVG 1691
            H IQ+LE CDFTPIYEWH                            YMWAIV+GVKEKVG
Sbjct: 300  HIIQNLEDCDFTPIYEWHQKEKEKKKQMTTEEKKVIKEEKMKQEEKYMWAIVDGVKEKVG 359

Query: 1692 NFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWKEIRHDNTV 1871
            NFRVEPPGLFRGRGEHPKMGKLK+RIRPSDITINIGKDAPIPECPIPGESWKEIRHDNTV
Sbjct: 360  NFRVEPPGLFRGRGEHPKMGKLKRRIRPSDITINIGKDAPIPECPIPGESWKEIRHDNTV 419

Query: 1872 TWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYILGIRAAYTKDFTSKD 2051
            TWLA+WNDPINPKE KYVFLAASSTLKGQSDKEKYEK+RLLKDYI GIRA+YTKDF SKD
Sbjct: 420  TWLAFWNDPINPKEIKYVFLAASSTLKGQSDKEKYEKSRLLKDYIQGIRASYTKDFASKD 479

Query: 2052 PAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSI 2231
            P K+QIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEP+PPN LKFDFLGKDSI
Sbjct: 480  PTKKQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPMPPNILKFDFLGKDSI 539

Query: 2232 RYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNAS 2411
            RYQNEVEVE+AVFKAIQQFRSGKK  DDLFD+LDTSKLNAHLKELMPGLTAKVFRTYNAS
Sbjct: 540  RYQNEVEVESAVFKAIQQFRSGKKAADDLFDKLDTSKLNAHLKELMPGLTAKVFRTYNAS 599

Query: 2412 ITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKG 2591
            ITLD+MLS++T+ GDVAE +VVYQHANKEVAIICNHQRTVSKSHSAQMLRLNEKIEELK 
Sbjct: 600  ITLDEMLSKDTKAGDVAENIVVYQHANKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKV 659

Query: 2592 VVEELQTDLARAKKGKPPLKSADGKPKRNMNP 2687
            V+EEL TDL RAKKGKPPLKSADGK KRN+NP
Sbjct: 660  VLEELTTDLVRAKKGKPPLKSADGKTKRNLNP 691


>dbj|BAK32958.1| topoisomerase I [Ophiorrhiza pedunculata]
          Length = 920

 Score =  975 bits (2520), Expect = 0.0
 Identities = 519/846 (61%), Positives = 589/846 (69%), Gaps = 33/846 (3%)
 Frame = +3

Query: 249  MAVEACDKQKLXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDVR 428
            MAVEAC    L         P++FKR            E KK   QKH  Q      DVR
Sbjct: 1    MAVEACTTTNLMEDMEDDEGPVIFKRSNPASKQNQANSEKKKLSLQKHVGQSAVHTSDVR 60

Query: 429  SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 608
              NG+++  +K +  P +KTPPVK PL+SPK+SN+S KA  + SP  +SKPS S T  + 
Sbjct: 61   PANGENSSAQKGRIQPSAKTPPVKSPLSSPKASNSSAKASPITSPGANSKPSASATSTAK 120

Query: 609  SVKHQIKD----EKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTST 776
               H        E   +    + N +S+ S+D+KPLSAR     SK  SNHA K    S 
Sbjct: 121  QQNHHKSSAAFIEPKPSVPAAKANSNSESSDDEKPLSARTFGCSSKGKSNHANKEGGDSC 180

Query: 777  LSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE-- 950
              ++  I   EDS+DE PLS +F  KS+ GES ++S +S E+KPL +K   NGSAS +  
Sbjct: 181  SIRRPVIEESEDSEDEKPLSRRFTSKSSLGESTSKSYDSDEKKPLAAKVQPNGSASRDSP 240

Query: 951  -RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDE------- 1106
              K ++   KRP   VK+ ++S LKKPKLS   T   NK+A++K E + EDD+       
Sbjct: 241  MNKSASLSNKRPPGEVKSLNQSSLKKPKLSSPITSISNKQAAVKPEPKAEDDDDNIPLSQ 300

Query: 1107 -----------------DHVPISHRMXXXXXXXXXXXXXXN-ITKPIXXXXXXXXXXXXX 1232
                             D+VPIS R+                 +  +             
Sbjct: 301  RGKKSQTATSKPKDEDDDNVPISQRIKKSPASVSKSSAPVKKASTVVSPSLKKVNKKSKK 360

Query: 1233 XXXXXXXXXXXXXXXXXGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEV 1412
                             GEGQKWTTLVHNGVIFPPPYKPHGVKMLYK +P+ LTPEQEEV
Sbjct: 361  VIKKTAYTKSSKVPPGSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKRQPITLTPEQEEV 420

Query: 1413 ATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXX 1592
            ATM+AVML+TDYMNKP+FKENF +DW+K+LGKNHTIQ+LE CDF PIYEWH         
Sbjct: 421  ATMFAVMLDTDYMNKPRFKENFFSDWKKMLGKNHTIQNLEDCDFGPIYEWHQQEKEKKKQ 480

Query: 1593 XXXXXXXXXXXXXXXXXXXYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR 1772
                               YMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR
Sbjct: 481  MTTEEKKALKEEKLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR 540

Query: 1773 PSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLK 1952
            P DITINIGKDAPIPECPIPGE WKE+R+DNTVTWLAYWNDPIN KEFKYVFLAASSTLK
Sbjct: 541  PRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAYWNDPINQKEFKYVFLAASSTLK 600

Query: 1953 GQSDKEKYEKARLLKDYILGIRAAYTKDFTS-KDPAKRQIAVATYLIDKLALRAGNEKDD 2129
            GQSDKEKYEKARLLKDYI GIRAAYTKDFT+ KDP K+QIAVATYLIDKLALRAGNEKDD
Sbjct: 601  GQSDKEKYEKARLLKDYIHGIRAAYTKDFTNNKDPMKKQIAVATYLIDKLALRAGNEKDD 660

Query: 2130 DEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGG 2309
            DEADTVGCCTLKVENVEPVPPN LKFDFLGKDSIRYQNEV+VE AVFKAI QFRSGK+G 
Sbjct: 661  DEADTVGCCTLKVENVEPVPPNILKFDFLGKDSIRYQNEVQVEPAVFKAIHQFRSGKEGS 720

Query: 2310 DDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHA 2489
            +DLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLS++T GG+VAEKVVVYQHA
Sbjct: 721  EDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKKTNGGEVAEKVVVYQHA 780

Query: 2490 NKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGKP 2669
            NKEVAIICNHQRTVSKSHSAQM RLNEKI+ELK  +EEL+TDL+RAKKGKP  K ADGKP
Sbjct: 781  NKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTALEELKTDLSRAKKGKPLSKGADGKP 840

Query: 2670 KRNMNP 2687
            KRN+NP
Sbjct: 841  KRNLNP 846


>dbj|BAK32962.1| topoisomerase I [Ophiorrhiza trichocarpon var. glabra]
          Length = 920

 Score =  973 bits (2514), Expect = 0.0
 Identities = 518/846 (61%), Positives = 589/846 (69%), Gaps = 33/846 (3%)
 Frame = +3

Query: 249  MAVEACDKQKLXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDVR 428
            MAVEAC    L         P++FKR            E KK   Q+H  Q      DVR
Sbjct: 1    MAVEACTTTNLMEDMEDDEGPVIFKRSNPASKQNQANSEKKKLSLQRHVGQSAVHTSDVR 60

Query: 429  SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 608
              NG+++  +K +  P +KTPPVK PL+SPK+SN+S KA  + S   +SKPS S T  + 
Sbjct: 61   PANGENSSAQKGRIQPSAKTPPVKSPLSSPKASNSSAKASPITSAGANSKPSASATSTAK 120

Query: 609  SVKHQIKD----EKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTST 776
               H        E   +    + N +S+ S+D+KPLSAR     SK  SNHA K    S 
Sbjct: 121  QQNHHKSSAAFIEPKPSVPAAKANSNSESSDDEKPLSARTFGCSSKGKSNHANKEGGDSC 180

Query: 777  LSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE-- 950
              ++  I   EDS+DE PLS +F  KS+ GES ++S +S E+KPL +K   NGSAS +  
Sbjct: 181  SIRRPVIEESEDSEDEKPLSRRFTSKSSLGESTSKSYDSDEKKPLAAKVQPNGSASRDSP 240

Query: 951  -RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDE------- 1106
              K ++   KRP   VK+ ++S LKKPKLS   T   NK+A++K E + EDD+       
Sbjct: 241  MNKSASLSNKRPPGEVKSLNQSSLKKPKLSSPITSISNKQAAVKPEPKAEDDDDNIPLSQ 300

Query: 1107 -----------------DHVPISHRMXXXXXXXXXXXXXXN-ITKPIXXXXXXXXXXXXX 1232
                             D+VPIS R+                 +  +             
Sbjct: 301  RGKKSQTATSKPKDEDDDNVPISQRIKKSPASVSKSSAPVKKASTVVSPSLKKVNKKSKK 360

Query: 1233 XXXXXXXXXXXXXXXXXGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEV 1412
                             GEGQKWTTLVHNGVIFPPPYKPHGVKMLYK +P+ LTPEQEEV
Sbjct: 361  VIKKTAYTKSSKVPPGSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKRQPITLTPEQEEV 420

Query: 1413 ATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXX 1592
            ATM+AVML+TDYMNKP+FKENF +DW+K+LGKNHTIQ+LE CDF PIYEWH         
Sbjct: 421  ATMFAVMLDTDYMNKPRFKENFFSDWKKMLGKNHTIQNLEDCDFGPIYEWHQQEKEKKKQ 480

Query: 1593 XXXXXXXXXXXXXXXXXXXYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR 1772
                               YMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR
Sbjct: 481  MTTEEKKALKEEKLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR 540

Query: 1773 PSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLK 1952
            P DITINIGKDAPIPECPIPGE WKE+R+DNTVTWLAYWNDPIN KEFKYVFLAASSTLK
Sbjct: 541  PRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAYWNDPINQKEFKYVFLAASSTLK 600

Query: 1953 GQSDKEKYEKARLLKDYILGIRAAYTKDFTS-KDPAKRQIAVATYLIDKLALRAGNEKDD 2129
            GQSDKEKYEKARLLKDYI GIRAAYTKDFT+ KDP K+QIAVATYLIDKLALRAGNEKDD
Sbjct: 601  GQSDKEKYEKARLLKDYIHGIRAAYTKDFTNNKDPMKKQIAVATYLIDKLALRAGNEKDD 660

Query: 2130 DEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGG 2309
            DEADTVGCCTLKVENVEPVPPN LKFDFLGKDSIRYQNEV+VE AVFKAIQQFRSGK+G 
Sbjct: 661  DEADTVGCCTLKVENVEPVPPNILKFDFLGKDSIRYQNEVQVEPAVFKAIQQFRSGKEGS 720

Query: 2310 DDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHA 2489
            +DLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLS++T GG+VAEKVVVYQHA
Sbjct: 721  EDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKKTNGGEVAEKVVVYQHA 780

Query: 2490 NKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGKP 2669
            NKEVAIICNHQRTVSKSHSAQM RLNEKI+ELK  +EEL+TDL+RAKKGKP  K ADGKP
Sbjct: 781  NKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTALEELKTDLSRAKKGKPLSKGADGKP 840

Query: 2670 KRNMNP 2687
            KRN+NP
Sbjct: 841  KRNLNP 846


>dbj|BAK32960.1| topoisomerase I [Ophiorrhiza pseudofasciculata]
          Length = 925

 Score =  969 bits (2506), Expect = 0.0
 Identities = 519/846 (61%), Positives = 587/846 (69%), Gaps = 33/846 (3%)
 Frame = +3

Query: 249  MAVEACDKQKLXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDVR 428
            MAVEAC    L         P++FKR            E KK   QK D Q      DVR
Sbjct: 1    MAVEACTTN-LMEDMEDDGGPVIFKRSKPAPKQNQANSEKKKLSLQKQDGQSAVHTSDVR 59

Query: 429  SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 608
              NG+S+  +K +  P +KTPPVK PL+SPK+SN+S KA  + SP  +SKPS S T  + 
Sbjct: 60   PANGESSSAQKGRIQPSAKTPPVKSPLSSPKASNSSAKASPITSPGANSKPSASATSTAK 119

Query: 609  SVKHQIKD----EKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTST 776
               H        E   +    + N +S+ S+D+KPLSAR     SK  SNHA K    S 
Sbjct: 120  QQNHHKSSAAFIEPKPSVPAAKANSNSESSDDEKPLSARTFGCSSKGKSNHANKEGGDSC 179

Query: 777  LSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE-- 950
              ++  I   EDS+DE PLS +F  KS+ GES ++S +S E+KPL +K  QNGSAS +  
Sbjct: 180  SIRRPVIEESEDSEDEKPLSCRFTSKSSLGESTSKSYDSDEKKPLAAKVQQNGSASRDGP 239

Query: 951  -RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDE------- 1106
              K ++   KRP    K+ ++S +KKPKLS   T   NK+A++K E + EDD+       
Sbjct: 240  MNKSASLSNKRPPGEAKSLNQSSVKKPKLSSPITSISNKQAAVKPEPKAEDDDDNIPLSQ 299

Query: 1107 -----------------DHVPISHRMXXXXXXXXXXXXXXN-ITKPIXXXXXXXXXXXXX 1232
                             D+VPIS R+                 +  +             
Sbjct: 300  RGKKSQSATSKPKDDDDDNVPISQRIKKSPASVSKSSVPVKKASTVVSSSLKKVNKNSKK 359

Query: 1233 XXXXXXXXXXXXXXXXXGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEV 1412
                             GEGQKWTTLVHNGVIFPPPYKPHGVKMLYK +P+ LTPEQEEV
Sbjct: 360  VIKKTAYTKSSKVPPGSGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKRQPITLTPEQEEV 419

Query: 1413 ATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXX 1592
            ATM+AVML+TDYMNKP FKENF +DW+KILGKNH IQ+LE CDF PIYEWH         
Sbjct: 420  ATMFAVMLDTDYMNKPCFKENFFSDWKKILGKNHMIQNLEDCDFGPIYEWHQQEKEKKKQ 479

Query: 1593 XXXXXXXXXXXXXXXXXXXYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR 1772
                               YMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR
Sbjct: 480  MTTEEKKALKEEKLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIR 539

Query: 1773 PSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLK 1952
            P DITINIGKDAPIPECPIPGE WKE+R+ NTVTWLAYWNDPIN KEFKYVFLAASSTLK
Sbjct: 540  PRDITINIGKDAPIPECPIPGERWKEVRNGNTVTWLAYWNDPINQKEFKYVFLAASSTLK 599

Query: 1953 GQSDKEKYEKARLLKDYILGIRAAYTKDFTS-KDPAKRQIAVATYLIDKLALRAGNEKDD 2129
            GQSDKEKYEKARLLKDYI GIRAAYTKDFT+ KDP K+QIAVATYLIDKLALRAGNEKDD
Sbjct: 600  GQSDKEKYEKARLLKDYIHGIRAAYTKDFTNNKDPMKKQIAVATYLIDKLALRAGNEKDD 659

Query: 2130 DEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGG 2309
            DEADTVGCCTLKVENVEPVPPN LKFDFLGKDSIRYQNEV+VE AVFKAIQQFRSGK+G 
Sbjct: 660  DEADTVGCCTLKVENVEPVPPNILKFDFLGKDSIRYQNEVQVEPAVFKAIQQFRSGKEGS 719

Query: 2310 DDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHA 2489
            +DLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLS+ET+GG+VAE VVVYQHA
Sbjct: 720  EDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKETKGGEVAENVVVYQHA 779

Query: 2490 NKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGKP 2669
            NKEVAIICNHQRTVSKSHSAQM RLNEKI+ELK  +EEL+TDL+RAKKGKPP K ADGK 
Sbjct: 780  NKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTALEELKTDLSRAKKGKPPTKGADGKA 839

Query: 2670 KRNMNP 2687
            KRN+NP
Sbjct: 840  KRNLNP 845


>dbj|BAG31375.1| topoisomerase I [Ophiorrhiza japonica]
          Length = 927

 Score =  969 bits (2505), Expect = 0.0
 Identities = 516/848 (60%), Positives = 590/848 (69%), Gaps = 35/848 (4%)
 Frame = +3

Query: 249  MAVEACDKQKLXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDVR 428
            MAVEAC    L         P++FKR            E KK   QKH  Q      DVR
Sbjct: 1    MAVEACTPN-LMEDMEDDEGPVIFKRSNPASKQNQANSEKKKLSLQKHVGQSAVHTSDVR 59

Query: 429  SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 608
              NG+S+  +K +  P +KTPPVK PL+SPK+SN+S KA  + SP  +SKPS S T  + 
Sbjct: 60   PANGESSSAQKGRIQPSAKTPPVKSPLSSPKASNSSAKASPITSPGANSKPSASATSTAK 119

Query: 609  SVKHQIKD----EKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTST 776
               H        E   +    + N +S+ S+D+KPLSAR     SK  SNHA K    S 
Sbjct: 120  QQNHHKSSAAFIEPKPSVPAAKANSNSESSDDEKPLSARTFGCSSKGKSNHANKEGGDSC 179

Query: 777  LSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE-- 950
              ++R I   EDS+DE PLS +F  KS+ GES ++S +S E+KPL +K  QNGS S +  
Sbjct: 180  SIRRRVIEESEDSEDEKPLSRRFTSKSSLGESTSKSYDSDEKKPLAAKVQQNGSVSRDGP 239

Query: 951  -RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMR------------ 1091
              K ++   KRP   VK+ ++S +KKPKLS   T   NK+A++K E              
Sbjct: 240  MNKSASLSNKRPPGEVKSLNQSSVKKPKLSSPITSISNKQAAVKPEPEPKAEDDDDNIPL 299

Query: 1092 --------------EEDDEDHVPISHRMXXXXXXXXXXXXXXN-ITKPIXXXXXXXXXXX 1226
                          +++D+D+VPI+ R+                 +  +           
Sbjct: 300  SQRGKKSQAATSKPKDEDDDNVPIAQRIKKSPASVSKSSAPVKKASTVVSPSLKKVNKNS 359

Query: 1227 XXXXXXXXXXXXXXXXXXXGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQE 1406
                               GEGQKWTTLVHNGVIFPPPY PHGVKMLYK +P+ LTPEQE
Sbjct: 360  KKVIKKTAYTKSSKVPPGSGEGQKWTTLVHNGVIFPPPYNPHGVKMLYKRQPITLTPEQE 419

Query: 1407 EVATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXX 1586
            EVATM+AVML+TDYMNKP+FKENF +DW+K+LGKNHTIQ+LE CDF PIYEWH       
Sbjct: 420  EVATMFAVMLDTDYMNKPRFKENFFSDWKKMLGKNHTIQNLEDCDFGPIYEWHQQEKEKK 479

Query: 1587 XXXXXXXXXXXXXXXXXXXXXYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKR 1766
                                 YMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKR
Sbjct: 480  KQMTTEEKKALKEDKLQQEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKR 539

Query: 1767 IRPSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASST 1946
            IRP DITINIGKDAPIPECPIPGE WKE+R+DNTVTWLA+W DPIN KEFKYVFLAASST
Sbjct: 540  IRPRDITINIGKDAPIPECPIPGERWKEVRNDNTVTWLAFWIDPINQKEFKYVFLAASST 599

Query: 1947 LKGQSDKEKYEKARLLKDYILGIRAAYTKDFTS-KDPAKRQIAVATYLIDKLALRAGNEK 2123
            LKGQSDKEKYEKARLLKDYI GIRAAYTKDFT+ KDP K+QIAVATYLIDKLALRAGNEK
Sbjct: 600  LKGQSDKEKYEKARLLKDYIHGIRAAYTKDFTNNKDPMKKQIAVATYLIDKLALRAGNEK 659

Query: 2124 DDDEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKK 2303
            DDDEADTVGCCTLKVENVEPVPPN LKFDFLGKDSIRYQNEV+VE AVFKAIQQFRSGK+
Sbjct: 660  DDDEADTVGCCTLKVENVEPVPPNILKFDFLGKDSIRYQNEVQVEPAVFKAIQQFRSGKE 719

Query: 2304 GGDDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQ 2483
            G +DLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLS+ET+GG+VAEKVVVYQ
Sbjct: 720  GSEDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSKETKGGEVAEKVVVYQ 779

Query: 2484 HANKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADG 2663
            HANKEVAIICNHQRTVSKSHSAQM RLNEKI+ELK  +EEL+TDL+R KKGKPP K ADG
Sbjct: 780  HANKEVAIICNHQRTVSKSHSAQMSRLNEKIDELKTAMEELKTDLSRVKKGKPPSKGADG 839

Query: 2664 KPKRNMNP 2687
            KPKRN+NP
Sbjct: 840  KPKRNLNP 847


>ref|XP_010266803.1| PREDICTED: DNA topoisomerase 1 alpha-like [Nelumbo nucifera]
          Length = 890

 Score =  917 bits (2371), Expect = 0.0
 Identities = 496/830 (59%), Positives = 570/830 (68%), Gaps = 16/830 (1%)
 Frame = +3

Query: 246  LMAVEACDKQKLXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDV 425
            +MAV+AC K K          P++FKR            E KK  S+K D   G+   D 
Sbjct: 1    MMAVDACIKPKFFDDGDDDEGPIIFKRNNASSKKNQLNKELKKVSSRKRDGSSGKCVSDS 60

Query: 426  RSQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDK- 602
             S NGQ++ ++K K V                    S KA   KS E  SK STS+TDK 
Sbjct: 61   FSPNGQNSSLQKGKAVQ-------------------SSKASTGKSTETSSKASTSITDKL 101

Query: 603  -SNSVKHQIKD--EKLSTEATGEPNEDSQDSEDDKPLSARLP--AGLSKVNSNHAKKSPN 767
              +  K+   D  EK   +   EP  DS DS+DDKPLS RLP  A L K  S+   K  +
Sbjct: 102  KCSPQKNSSIDNMEKQLKKPCNEPYTDSVDSDDDKPLSIRLPTSASLLKCKSSPVSKGLS 161

Query: 768  T----STLSQKRRIP---IPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYD 926
            +    S+ S+K  +      EDS+DE+PLS K ++K + G S  +  +SGE KPL+SK  
Sbjct: 162  SPVASSSQSEKTNVTNKKSSEDSEDELPLSLKLKLKPSVGLSGKKFYDSGEEKPLVSKLQ 221

Query: 927  QNGSASTERKP---STNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREE 1097
            QNGS+  + +P     NL KRP  G  ++ +S +KK K+SE + P K K+ SIK+E +EE
Sbjct: 222  QNGSSKRDNEPLKSPKNLNKRPLSGANSSGQSLVKKLKVSEVSVPTKVKQTSIKSEPKEE 281

Query: 1098 DDEDHVPISHRMXXXXXXXXXXXXXXNITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXX 1277
            D++D +PIS R+                TK +                            
Sbjct: 282  DEDD-IPISQRLKKSASSDDKSLSLKKTTKVVSSSFKKTTNKLKKAAKNSKYSKSTKMPP 340

Query: 1278 XXGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNK 1457
              GEGQKWTTL HNGVIFPP YKPHGVKMLY GKPVDLTPEQEEVATM+AVM +TDY  K
Sbjct: 341  SSGEGQKWTTLEHNGVIFPPLYKPHGVKMLYNGKPVDLTPEQEEVATMFAVMKDTDYATK 400

Query: 1458 PKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXX 1637
             +F ENFM DWR ILGKNH I+  E CDFTPIYEWH                        
Sbjct: 401  SRFIENFMNDWRTILGKNHVIKKFELCDFTPIYEWHQREKEKKKQMSAEEKKALKEEKLK 460

Query: 1638 XXXXYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIP 1817
                YMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRI PSDITINIGK APIP
Sbjct: 461  QEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIHPSDITINIGKGAPIP 520

Query: 1818 ECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLK 1997
            ECPIPGE WKE+RHDNTVTWLA+WNDPINPKEFKYVFLAASS+LKGQSDKEKYEKARLLK
Sbjct: 521  ECPIPGERWKEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARLLK 580

Query: 1998 DYILGIRAAYTKDFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENV 2177
            DYI  IRA YT+DF SKD  KRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENV
Sbjct: 581  DYIKDIRANYTRDFVSKDITKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENV 640

Query: 2178 EPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHL 2357
            E VPPN L+FDFLGKDSIRY N VEVE AV+KAI QF++GK+ G+DLFD LDTSKLNAHL
Sbjct: 641  ELVPPNKLQFDFLGKDSIRYFNTVEVELAVYKAIGQFKNGKEDGEDLFDSLDTSKLNAHL 700

Query: 2358 KELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSK 2537
            KELMPGLTAKVFRTYNASITLD+ML+RE++GGDVAEK+ VYQHANKEVAIICNHQR+VSK
Sbjct: 701  KELMPGLTAKVFRTYNASITLDEMLNRESKGGDVAEKIAVYQHANKEVAIICNHQRSVSK 760

Query: 2538 SHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNMNP 2687
            SHSAQM RL++KI+ELK  ++EL+TDLARAKKGKPPLK ADGKPKRN+ P
Sbjct: 761  SHSAQMHRLDDKIKELKDALDELKTDLARAKKGKPPLKGADGKPKRNLTP 810


>ref|XP_023553297.1| DNA topoisomerase 1 beta-like [Cucurbita pepo subsp. pepo]
          Length = 887

 Score =  914 bits (2361), Expect = 0.0
 Identities = 488/820 (59%), Positives = 570/820 (69%), Gaps = 7/820 (0%)
 Frame = +3

Query: 249  MAVEACDKQKLXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDVR 428
            MAVE   K  +         P+VFKR            E K S SQ+ ++  GRP  D  
Sbjct: 1    MAVETFGKAPMFDDDDEDNMPIVFKRSSASRQNQLNS-EVKHSQSQRLNQLSGRPGSDAC 59

Query: 429  SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPST-SVTDKS 605
            S NGQS+  +K  T  L KT P++  + S K+S +S     ++ P V S  +T  V+D  
Sbjct: 60   SANGQSSNAQKRMT-SLPKTSPMRPEIGSQKASKSS-----IQEPLVKSLGTTLKVSDSM 113

Query: 606  NSVKHQIKDEKLSTEATG-EPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTSTLS 782
            +S   Q+ +  +  E     P +D+ DSEDDKPLS RL     K NSNH  K P   T+ 
Sbjct: 114  DSRPKQLANAAVKEENDSIHPTQDNSDSEDDKPLSIRL-----KGNSNHPSKGP-IPTVQ 167

Query: 783  QKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTER--K 956
            + +     EDSDDE+PLSSKFQ+KS +G    R     E+KPL SK  QNGS S ++  K
Sbjct: 168  KNKIKKSSEDSDDEVPLSSKFQMKSASGVLGGRQHGFDEKKPLDSKVHQNGSTSRDKLQK 227

Query: 957  PSTNLKKRPGDGVKTTDESYL--KKPKLSEAATPHKNKEASIKAEMREEDDEDHVPISHR 1130
            P+    KRP     +   S +  KKPKLS+++TP      S+KA+    DD+DH+PIS R
Sbjct: 228  PAVVSSKRPLPNADSHSSSQISSKKPKLSDSSTPLSTNTVSLKAKQEVADDDDHIPISQR 287

Query: 1131 MXXXXXXXXXXXXXXNITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGEGQK-WTT 1307
            M               ++K                                G+GQK WTT
Sbjct: 288  MKMSAAVNKSSGSKKTVSKVASSSIKKTLKKSKKPVKKSKYVKSTKLLPSSGDGQKKWTT 347

Query: 1308 LVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKPKFKENFMAD 1487
            LVHNGVIFPPPY+ HGVK+L+KGKPVDLTPEQEEVATM+AVM +TDYM KPKFKENF  D
Sbjct: 348  LVHNGVIFPPPYQTHGVKILHKGKPVDLTPEQEEVATMFAVMKDTDYMQKPKFKENFWND 407

Query: 1488 WRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXXXXXYMWAIV 1667
            WRK+LGKNH IQ+L+ CDFTPIY+W+                            YMWAI+
Sbjct: 408  WRKLLGKNHVIQNLDDCDFTPIYDWYQTEKEKKKQMTTEEKKALKEEKLKQEEKYMWAIL 467

Query: 1668 NGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWK 1847
            +GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPG+ WK
Sbjct: 468  DGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGQRWK 527

Query: 1848 EIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYILGIRAAY 2027
            E+RHDNTVTWLA+WNDPINPKEFKYVFLAASS+LKGQSDKEKYEKAR+LKDYI  IR +Y
Sbjct: 528  EVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNSY 587

Query: 2028 TKDFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNTLKF 2207
            TKDFTSKDP +RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENV+ VPPN L+F
Sbjct: 588  TKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEF 647

Query: 2208 DFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLKELMPGLTAK 2387
            +FLGKDSI+Y+N VEVE  VFKAI QF+SGK G DDLFD+LDTSKLNAHLK+LMPGLTAK
Sbjct: 648  NFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAK 707

Query: 2388 VFRTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMLRLN 2567
            VFRTYNASITLDDML+R T+ G+V+EK+V YQHANKEVAIICNHQRTVSKSH AQM RLN
Sbjct: 708  VFRTYNASITLDDMLNRGTKDGEVSEKIVTYQHANKEVAIICNHQRTVSKSHGAQMTRLN 767

Query: 2568 EKIEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNMNP 2687
            EKI EL+ +V+EL+ DL RAKKGKPPLK +DGK KRN+ P
Sbjct: 768  EKISELRDIVKELKIDLDRAKKGKPPLKGSDGKQKRNLTP 807


>gb|KVI01089.1| DNA breaking-rejoining enzyme, catalytic core [Cynara cardunculus
            var. scolymus]
          Length = 778

 Score =  914 bits (2361), Expect = 0.0
 Identities = 475/712 (66%), Positives = 531/712 (74%), Gaps = 2/712 (0%)
 Frame = +3

Query: 558  SPEVDSKPSTSVTDKSNSVKHQIKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKV 737
            S + D KP   +  + +S   ++K    S   + +P+ D  DSEDDKPLS RL   +SK 
Sbjct: 4    SSDEDDKP---LVFRRSSKADKVKCSSQSLRPSPKPSNDLTDSEDDKPLSFRLST-VSKG 59

Query: 738  NSNHAKKSPNTSTLSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLS 917
            N+NHAKK    +     +     EDSDDE PLSSK+  K N   SI++ S S   K L S
Sbjct: 60   NTNHAKKGSCMNVSPLPKPQVKDEDSDDEKPLSSKYISKPNVVSSISKHSGSNNDKTLTS 119

Query: 918  KYDQNGSASTERKP-STNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMRE 1094
            K  QNGSAS + +  ST   KRP D  +++ +S  KKPKLSE++TP   K+  +KAE   
Sbjct: 120  KVHQNGSASRDNQSRSTGSIKRPLDEERSSSQSLAKKPKLSESSTPINRKQVPLKAETES 179

Query: 1095 EDDE-DHVPISHRMXXXXXXXXXXXXXXNITKPIXXXXXXXXXXXXXXXXXXXXXXXXXX 1271
            +DDE D VPIS R+              +                               
Sbjct: 180  DDDEEDDVPISQRIKNHAPSGSKSSSVKHKVTKKNSSLKETNKKSKKVVKNSKYSKPSKV 239

Query: 1272 XXXXGEGQKWTTLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYM 1451
                GEGQKWT+LVH+GVIFPP YKPHGVK+LYKGKPVDLTPEQEEVATM+AVML+TDYM
Sbjct: 240  PPGSGEGQKWTSLVHSGVIFPPAYKPHGVKILYKGKPVDLTPEQEEVATMFAVMLDTDYM 299

Query: 1452 NKPKFKENFMADWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXX 1631
             KPKFKENF  DWRKILG+NHTIQ+L+ CDF PIYEWH                      
Sbjct: 300  TKPKFKENFWDDWRKILGRNHTIQNLDDCDFKPIYEWHQTEKEKKKQMSTEEKKALKEEK 359

Query: 1632 XXXXXXYMWAIVNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAP 1811
                  YMWAIV+GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRI PSDITINIGKDAP
Sbjct: 360  MKLEEKYMWAIVDGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIHPSDITINIGKDAP 419

Query: 1812 IPECPIPGESWKEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARL 1991
            IPECPIPGESWKEIRHDNTVTWLAYWNDPIN KEFKYVFLAASS+LKGQSDKEKYEKAR+
Sbjct: 420  IPECPIPGESWKEIRHDNTVTWLAYWNDPINSKEFKYVFLAASSSLKGQSDKEKYEKARM 479

Query: 1992 LKDYILGIRAAYTKDFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVE 2171
            LK YI GIR AYT+DF +KD  KRQ+AVATYLIDKLALRAGNEKDDDEADTVGCCTLKVE
Sbjct: 480  LKGYIQGIRNAYTRDFGNKDLTKRQVAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVE 539

Query: 2172 NVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNA 2351
            NVEP PPN LKFDFLGKDSIRYQNEVEVE  VFKAIQQFR+GK+G DDLFD+LDTSKLNA
Sbjct: 540  NVEPKPPNILKFDFLGKDSIRYQNEVEVELPVFKAIQQFRTGKQGTDDLFDKLDTSKLNA 599

Query: 2352 HLKELMPGLTAKVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTV 2531
            HLKELMPGLTAKVFRTYNASITLDDMLSRET+GGDVA+ +VVYQHANKEVAIICNHQRTV
Sbjct: 600  HLKELMPGLTAKVFRTYNASITLDDMLSRETKGGDVAQNLVVYQHANKEVAIICNHQRTV 659

Query: 2532 SKSHSAQMLRLNEKIEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNMNP 2687
            SKSHSAQM RLNEKI+ELKGV++EL+TDL RAKKGKPPLK++DGKPKRN+NP
Sbjct: 660  SKSHSAQMTRLNEKIDELKGVIKELETDLVRAKKGKPPLKNSDGKPKRNLNP 711


>ref|XP_023007686.1| DNA topoisomerase 1 beta-like [Cucurbita maxima]
 ref|XP_023007687.1| DNA topoisomerase 1 beta-like [Cucurbita maxima]
 ref|XP_023007688.1| DNA topoisomerase 1 beta-like [Cucurbita maxima]
 ref|XP_023007689.1| DNA topoisomerase 1 beta-like [Cucurbita maxima]
          Length = 887

 Score =  907 bits (2345), Expect = 0.0
 Identities = 484/819 (59%), Positives = 569/819 (69%), Gaps = 6/819 (0%)
 Frame = +3

Query: 249  MAVEACDKQKLXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDVR 428
            MAVE   K  +         P+VFKR            E K S SQ+ ++  GRP  D  
Sbjct: 1    MAVETFGKATMFDDDDEDNMPIVFKRSSASRQNQLNS-EVKHSQSQRLNQLSGRPGSDAC 59

Query: 429  SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 608
            S NGQS+  +K  T  L KT P++  + S K+S +S +   +KS     K S S+  +  
Sbjct: 60   STNGQSSNAQKRMT-SLPKTSPMRPEIGSQKASKSSIQEPLVKSLGTTLKVSDSMDSRPK 118

Query: 609  S-VKHQIKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTSTLSQ 785
              V   +K+E  S      P +++ DSEDDKPLS RL     K NSNH  K P   T+ +
Sbjct: 119  QLVNAAVKEENDSIH----PAQENSDSEDDKPLSIRL-----KGNSNHPSKGP-IPTVQK 168

Query: 786  KRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTER--KP 959
             +     EDSDDE+PLSSKF++KS +G    +     E+KPL SK  QNGS S+++  KP
Sbjct: 169  NKIKKSSEDSDDEVPLSSKFRMKSASGVLGGKQHGFDEKKPLDSKVHQNGSTSSDKLQKP 228

Query: 960  STNLKKRPGDGVKTTDESYL--KKPKLSEAATPHKNKEASIKAEMREEDDEDHVPISHRM 1133
            +    KRP     +   S +  KKPKLS+++TP      S+KA+    DD+DH+PIS RM
Sbjct: 229  AVVSSKRPLPNADSHSSSQISSKKPKLSDSSTPLSTHTVSLKAKQEVVDDDDHIPISQRM 288

Query: 1134 XXXXXXXXXXXXXXNITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGEGQK-WTTL 1310
                           ++K                                G+GQK WTTL
Sbjct: 289  KMSAAVNKSSGSKKTVSKVASSSIKKTLKKSKKPVKKSKYVKSTKLLPSSGDGQKKWTTL 348

Query: 1311 VHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKPKFKENFMADW 1490
            VHNGVIFPPPY+ HGVK+L+KGKPVDLTPEQEEVATM+AVM +TDYM KPKFKENF  DW
Sbjct: 349  VHNGVIFPPPYQTHGVKILHKGKPVDLTPEQEEVATMFAVMKDTDYMQKPKFKENFWNDW 408

Query: 1491 RKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXXXXXYMWAIVN 1670
            RK+LGKNH IQ+L+ CDFTPIY+W+                            YMWAI++
Sbjct: 409  RKLLGKNHVIQNLDDCDFTPIYDWYQTEKEKKKQMTTEEKKALKEEKLKQEEKYMWAILD 468

Query: 1671 GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWKE 1850
            GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPG+ WKE
Sbjct: 469  GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGQRWKE 528

Query: 1851 IRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYILGIRAAYT 2030
            +RHDNTVTWLA+WNDPINPKEFKYVFLAASS+LKGQSDKEKYEKAR+LKDYI  IR +YT
Sbjct: 529  VRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNSYT 588

Query: 2031 KDFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNTLKFD 2210
            KDFTSKDP +RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENV+ VPPN L+F+
Sbjct: 589  KDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEFN 648

Query: 2211 FLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLKELMPGLTAKV 2390
            FLGKDSI+Y+N VEVE  VFKAI QF+SGK G DDLFD+LDTSKLNAHLK+LMPGLTAKV
Sbjct: 649  FLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAKV 708

Query: 2391 FRTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMLRLNE 2570
            FRTYNASITLDDML+R T+ G+V+EK+V YQHANKEVAIICNHQRTVSKSH AQM RLNE
Sbjct: 709  FRTYNASITLDDMLNRGTKDGEVSEKIVTYQHANKEVAIICNHQRTVSKSHGAQMTRLNE 768

Query: 2571 KIEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNMNP 2687
            KI EL+ +++EL+ DL RAKKGKPPLK +DGK KRN+ P
Sbjct: 769  KISELRDILKELKIDLDRAKKGKPPLKGSDGKQKRNLTP 807


>ref|XP_022932254.1| DNA topoisomerase 1 beta-like [Cucurbita moschata]
 ref|XP_022932255.1| DNA topoisomerase 1 beta-like [Cucurbita moschata]
 ref|XP_022932256.1| DNA topoisomerase 1 beta-like [Cucurbita moschata]
 ref|XP_022932257.1| DNA topoisomerase 1 beta-like [Cucurbita moschata]
          Length = 887

 Score =  905 bits (2338), Expect = 0.0
 Identities = 483/820 (58%), Positives = 569/820 (69%), Gaps = 7/820 (0%)
 Frame = +3

Query: 249  MAVEACDKQKLXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDVR 428
            MAVE   K  +         P+VFKR            E K S SQ+ ++  GRP  D  
Sbjct: 1    MAVETFGKAPMFDDDDEDNMPIVFKRSSASRQNQLNS-EVKHSQSQRLNQLSGRPGSDAC 59

Query: 429  SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPST-SVTDKS 605
            S NGQS+  +K  T  L KT P++  + S K++ +S     ++ P V S  +T  V+D  
Sbjct: 60   SANGQSSNAQKRMT-SLPKTSPMRPEIGSQKAAKSS-----IQEPLVKSLGTTLKVSDSM 113

Query: 606  NSVKHQIKDEKLSTEATG-EPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTSTLS 782
            +S   Q+ +  +  E     P +++ DSEDDKPLS RL     K NSNH  K P   T+ 
Sbjct: 114  DSRPKQLANAAVKEENDSIHPTQENSDSEDDKPLSIRL-----KGNSNHPSKGP-IPTVQ 167

Query: 783  QKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTER--K 956
            + +     EDSDDE+PLSSKFQ+KS +G    +     E+KPL SK  QNGS S ++  K
Sbjct: 168  KNKIKKSSEDSDDEVPLSSKFQMKSASGVLGGKQHGFHEKKPLDSKVHQNGSTSRDKLQK 227

Query: 957  PSTNLKKRPGDGVKTTDESYL--KKPKLSEAATPHKNKEASIKAEMREEDDEDHVPISHR 1130
            P+    KRP     +   S +  KKPKLS+++TP      S+KA+    DD+DH+PIS R
Sbjct: 228  PAVVSSKRPLPNADSHSSSQISSKKPKLSDSSTPLSTNTVSLKAKQEVVDDDDHIPISQR 287

Query: 1131 MXXXXXXXXXXXXXXNITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGEGQK-WTT 1307
            M               ++K                                G+GQK WTT
Sbjct: 288  MKMSAAVNKSSGSKKTVSKVASSSIKKTLKKSKKPVKKSKYVKSTKLLPSSGDGQKKWTT 347

Query: 1308 LVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKPKFKENFMAD 1487
            LVHNGVIFPPPY+ HGVK+L+KGKPVDLT EQEEVATM+AVM +TDYM KPKFKENF  D
Sbjct: 348  LVHNGVIFPPPYQTHGVKILHKGKPVDLTTEQEEVATMFAVMKDTDYMQKPKFKENFWND 407

Query: 1488 WRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXXXXXYMWAIV 1667
            WRK+LGKNH IQ+L+ CDFTPIY+W+                            YMWAI+
Sbjct: 408  WRKLLGKNHVIQNLDDCDFTPIYDWYQTEKEKKKQMTTEEKKALKEEKLKQEEKYMWAIL 467

Query: 1668 NGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWK 1847
            +GVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPG+ WK
Sbjct: 468  DGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGQRWK 527

Query: 1848 EIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYILGIRAAY 2027
            E+RHDNTVTWLA+WNDPINPKEFKYVFLAASS+LKGQSDKEKYEKAR+LKDYI  IR +Y
Sbjct: 528  EVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIKNIRNSY 587

Query: 2028 TKDFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNTLKF 2207
            TKDFTSKDP +RQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENV+ VPPN L+F
Sbjct: 588  TKDFTSKDPTRRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAVPPNLLEF 647

Query: 2208 DFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLKELMPGLTAK 2387
            +FLGKDSI+Y+N VEVE  VFKAI QF+SGK G DDLFD+LDTSKLNAHLK+LMPGLTAK
Sbjct: 648  NFLGKDSIKYENTVEVELPVFKAITQFQSGKSGSDDLFDKLDTSKLNAHLKDLMPGLTAK 707

Query: 2388 VFRTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMLRLN 2567
            VFRTYNASITLDDML+R T+ G+V+EK+V YQHANKEVAIICNHQRTVSKSH AQM RLN
Sbjct: 708  VFRTYNASITLDDMLNRGTKDGEVSEKIVTYQHANKEVAIICNHQRTVSKSHGAQMTRLN 767

Query: 2568 EKIEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNMNP 2687
            EKI EL+ +++EL+ DL RAKKGKPPLK +DGK KRN+ P
Sbjct: 768  EKISELRDILKELKIDLDRAKKGKPPLKGSDGKQKRNLTP 807


>gb|PON81509.1| DNA topoisomerase I [Trema orientalis]
          Length = 897

 Score =  894 bits (2309), Expect = 0.0
 Identities = 481/821 (58%), Positives = 565/821 (68%), Gaps = 8/821 (0%)
 Frame = +3

Query: 249  MAVEACDKQKLXXXXXXXXXPLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDVR 428
            MAV+A  K  L         P+VFKR            E KK LSQK D Q GR   D  
Sbjct: 1    MAVQAPAKPNLVDDYDEDE-PIVFKRTNPISKQNQLNSEVKKPLSQKPDGQSGRQISDRV 59

Query: 429  SQNGQSTIVKKSKTVPLSKTPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSN 608
            S N  ++  +K K V  ++   VK  + SPK+S +S K   LKSP  +SK STS+  +S 
Sbjct: 60   SLNDLNSSSQKGKVVQSNRALVVKSSVASPKASASSAKTSPLKSPITNSKTSTSLDGQSK 119

Query: 609  SVKHQ-----IKDEKLSTEATGEPNEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTS 773
                +     +K+EK S +     +  S+DSEDD PLSARL    S+  S    K    S
Sbjct: 120  FSLEKNKSSIVKEEKSSIKQPIRSDSHSEDSEDDIPLSARLKGSTSQ-GSKGLVKPTTAS 178

Query: 774  TLSQKRRIPIPEDSDDEIPLSSKFQVKSNAGESINRSSNSGERKPLLSKYDQNGSASTE- 950
             L    +  + ED  D  PLSS+FQ+K N G S ++ ++  ++KPLLS   QNGS  T+ 
Sbjct: 179  KLPPVTKSVVKEDDSDNEPLSSRFQMKPNVGTSGSKPNDFNDKKPLLSINKQNGSTVTDV 238

Query: 951  RKPSTNLKKRPGDGVKTTDESYLKKPKLSEAATPHKNKEASIKAEMREEDDEDHVPISHR 1130
            +KP     KRP D  K+ D+S +K+PKLS++    KNK+ S+KAE + +DD DHVPIS R
Sbjct: 239  KKPLNTNTKRPLDREKS-DQSSVKRPKLSDSPALLKNKQVSVKAESKVDDD-DHVPISQR 296

Query: 1131 MXXXXXXXXXXXXXXN-ITKPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGEGQK-WT 1304
            +                +TKP+                              G+GQK WT
Sbjct: 297  IKKSPASNNKSSTTKQKVTKPVSSSFKKTTKKFKKGAKNSKYSKSTKLSPSSGDGQKKWT 356

Query: 1305 TLVHNGVIFPPPYKPHGVKMLYKGKPVDLTPEQEEVATMYAVMLETDYMNKPKFKENFMA 1484
            TL+HNGVIFPPPY+PHGVK+ Y GKPVDLTP QEEVATM+AVM +TDY  K  F+ENF  
Sbjct: 357  TLIHNGVIFPPPYQPHGVKLFYNGKPVDLTPVQEEVATMFAVMKDTDYAEKKTFRENFWN 416

Query: 1485 DWRKILGKNHTIQSLEHCDFTPIYEWHXXXXXXXXXXXXXXXXXXXXXXXXXXXXYMWAI 1664
            DWRK+LGKNH IQ L+ CDFTPIY+W+                            YMWAI
Sbjct: 417  DWRKLLGKNHVIQKLDLCDFTPIYDWYQNEKEKKKQMSADEKKALKEEKLKQEEKYMWAI 476

Query: 1665 VNGVKEKVGNFRVEPPGLFRGRGEHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESW 1844
            V+GVKEKVGNFRVEPPGLFRGRGEHPK GKLK+RIRPSD+TINIGKDAP+PECPIPGE W
Sbjct: 477  VDGVKEKVGNFRVEPPGLFRGRGEHPKSGKLKRRIRPSDVTINIGKDAPVPECPIPGERW 536

Query: 1845 KEIRHDNTVTWLAYWNDPINPKEFKYVFLAASSTLKGQSDKEKYEKARLLKDYILGIRAA 2024
            KE+RHDNTVTWLA+WNDPINPKEFKYVFLAASS+LKGQSDKEKYEKAR+LKDYI  IRAA
Sbjct: 537  KEVRHDNTVTWLAFWNDPINPKEFKYVFLAASSSLKGQSDKEKYEKARMLKDYIHNIRAA 596

Query: 2025 YTKDFTSKDPAKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNTLK 2204
            YTKDFTSKD  KRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENV+ + PN L+
Sbjct: 597  YTKDFTSKDVTKRQIAVATYLIDKLALRAGNEKDDDEADTVGCCTLKVENVKAIAPNKLE 656

Query: 2205 FDFLGKDSIRYQNEVEVETAVFKAIQQFRSGKKGGDDLFDRLDTSKLNAHLKELMPGLTA 2384
            F+FLGKDSIRY+N VEVE  V+KAI QF+SGKKG DDLFD LDTSKLNAHLKELMPGLTA
Sbjct: 657  FNFLGKDSIRYENTVEVELPVYKAIIQFQSGKKGNDDLFDLLDTSKLNAHLKELMPGLTA 716

Query: 2385 KVFRTYNASITLDDMLSRETRGGDVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMLRL 2564
            KVFRTYNASITLDDML++ET+ GD+ EK  VY  ANK+VAIICNHQRT+SKSH AQM +L
Sbjct: 717  KVFRTYNASITLDDMLNQETKDGDLEEKKTVYNTANKQVAIICNHQRTISKSHEAQMSKL 776

Query: 2565 NEKIEELKGVVEELQTDLARAKKGKPPLKSADGKPKRNMNP 2687
             EKI EL+ VV+EL+ DL RA+KGKPPLK ADGK KRN++P
Sbjct: 777  MEKIRELEDVVKELEVDLERARKGKPPLKDADGKTKRNLSP 817


>gb|PNT12575.1| hypothetical protein POPTR_011G092700v3 [Populus trichocarpa]
          Length = 783

 Score =  863 bits (2229), Expect = 0.0
 Identities = 466/798 (58%), Positives = 544/798 (68%), Gaps = 5/798 (0%)
 Frame = +3

Query: 309  PLVFKRXXXXXXXXXXXXEAKKSLSQKHDRQLGRPAPDVRSQNGQSTIVKKSKT-VPLSK 485
            P+VFKR                S   + + +  +P+   ++ NGQS    K K+ +  S 
Sbjct: 23   PIVFKRGGN-----------STSKQNQPNLEAKKPSSSSQNSNGQSLNAHKGKSPISSSN 71

Query: 486  TPPVKYPLTSPKSSNTSGKALALKSPEVDSKPSTSVTDKSNSVKHQIKDEKLSTEATGEP 665
              PVK P+ SPK+S +S KA  +K P   S+  +S  D+S       K+E        +P
Sbjct: 72   ASPVKSPIGSPKASASSAKASPMKPPVTYSRVPSSSIDQS-------KEET-------KP 117

Query: 666  NEDSQDSEDDKPLSARLPAGLSKVNSNHAKKSPNTSTLSQKRRIPIPEDSDDEIPLSSKF 845
              D  DSEDDKPLS+R      K ++N+A K      ++   R+      DDE+PLSS+F
Sbjct: 118  IVDDDDSEDDKPLSSRF-----KGSTNNANKG-----VTVPARVKDEHSDDDEVPLSSRF 167

Query: 846  QVKSNAGESINRSSNSGERKPLLSKYDQNGSASTER--KPSTNLKKRPGDGVKTTDESYL 1019
              KSNAG S  ++ +S E+  L+SK   NGS + ++  K S    KRP D    +++S+ 
Sbjct: 168  AAKSNAGSSSCKTISSSEKILLVSKIQLNGSTAKDKQQKSSAVPTKRPMDNKVPSNQSFA 227

Query: 1020 KKPKLSEAATPHKNKEASIKAEMREEDDEDHVPISHRMXXXXXXXXXXXXXX-NITKPIX 1196
            KKPKLS+A+T    K+ ++KAE++ +DD DH+ IS RM               N+TK + 
Sbjct: 228  KKPKLSDAST---TKQVTVKAELKADDD-DHLTISQRMKKASSSSNKSLSVKQNVTKVVS 283

Query: 1197 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXGEGQK-WTTLVHNGVIFPPPYKPHGVKMLYK 1373
                                          +GQK W TLVHNGVIFPPPYKPHGVKMLYK
Sbjct: 284  FSSKKTTKNNKKQMQNSKYSKSTKVQPGSSDGQKKWKTLVHNGVIFPPPYKPHGVKMLYK 343

Query: 1374 GKPVDLTPEQEEVATMYAVMLETDYMNKPKFKENFMADWRKILGKNHTIQSLEHCDFTPI 1553
            GKPVDLTPEQEEVATM+AVM +T+Y+ KP+F +NF  DWR +LGKNH IQ LE CDF PI
Sbjct: 344  GKPVDLTPEQEEVATMFAVMKDTEYVQKPQFLQNFWNDWRTLLGKNHVIQKLEACDFNPI 403

Query: 1554 YEWHXXXXXXXXXXXXXXXXXXXXXXXXXXXXYMWAIVNGVKEKVGNFRVEPPGLFRGRG 1733
            YEWH                            YMWAIVNGVKEKVGNFRVEPPGLFRGRG
Sbjct: 404  YEWHQKEKEKKKQMSTEEKKAVREEKLKQEEMYMWAIVNGVKEKVGNFRVEPPGLFRGRG 463

Query: 1734 EHPKMGKLKKRIRPSDITINIGKDAPIPECPIPGESWKEIRHDNTVTWLAYWNDPINPKE 1913
            EHPKMGKLK RIRPSDITINIGKDAPIP+CPIPGE WKE++HDNTVTWLA+WNDPINPKE
Sbjct: 464  EHPKMGKLKSRIRPSDITINIGKDAPIPKCPIPGERWKEVKHDNTVTWLAFWNDPINPKE 523

Query: 1914 FKYVFLAASSTLKGQSDKEKYEKARLLKDYILGIRAAYTKDFTSKDPAKRQIAVATYLID 2093
            FKYVFLAASS+LKGQSDKEKYEKAR LKDYI  IR AYTKDF SKD  KRQIAVATYLID
Sbjct: 524  FKYVFLAASSSLKGQSDKEKYEKARKLKDYIHNIRTAYTKDFASKDITKRQIAVATYLID 583

Query: 2094 KLALRAGNEKDDDEADTVGCCTLKVENVEPVPPNTLKFDFLGKDSIRYQNEVEVETAVFK 2273
            KLALRAGNEKDDDEADTVGCCTLKV NVE +PPN LKFDFLGKDSIRY+N VEVE  V+K
Sbjct: 584  KLALRAGNEKDDDEADTVGCCTLKVANVECIPPNKLKFDFLGKDSIRYENTVEVELPVYK 643

Query: 2274 AIQQFRSGKKGGDDLFDRLDTSKLNAHLKELMPGLTAKVFRTYNASITLDDMLSRETRGG 2453
            AI+QF+  KK  DDLFD LDTSKLNAHLKELMPGLTAKVFRTYNASITLD+ L  ET  G
Sbjct: 644  AIRQFQVAKKPTDDLFDSLDTSKLNAHLKELMPGLTAKVFRTYNASITLDEKLYEETEDG 703

Query: 2454 DVAEKVVVYQHANKEVAIICNHQRTVSKSHSAQMLRLNEKIEELKGVVEELQTDLARAKK 2633
            DVAEK V+Y  ANK+VAIICNHQRT+SKSH AQM RL EK+EELKG ++E +TDL RAKK
Sbjct: 704  DVAEKFVIYNQANKQVAIICNHQRTISKSHDAQMSRLTEKLEELKGTLKEFKTDLDRAKK 763

Query: 2634 GKPPLKSADGKPKRNMNP 2687
            GKPPLK ADGK KRN+ P
Sbjct: 764  GKPPLKDADGKQKRNLTP 781