BLASTX nr result
ID: Coptis24_contig00003359
seq
BLASTX 2.2.25 [Feb-01-2011] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= Coptis24_contig00003359 (5938 letters) Database: ./nr 23,641,837 sequences; 8,123,359,852 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ref|XP_002278761.1| PREDICTED: uncharacterized protein LOC100259... 320 3e-84 ref|XP_004142921.1| PREDICTED: uncharacterized protein LOC101216... 229 8e-82 emb|CBI20623.3| unnamed protein product [Vitis vinifera] 229 1e-81 emb|CAN67283.1| hypothetical protein VITISV_021595 [Vitis vinifera] 306 3e-80 ref|XP_002516463.1| nucleic acid binding protein, putative [Rici... 221 7e-78 >ref|XP_002278761.1| PREDICTED: uncharacterized protein LOC100259454 [Vitis vinifera] Length = 690 Score = 320 bits (820), Expect = 3e-84 Identities = 184/400 (46%), Positives = 215/400 (53%), Gaps = 13/400 (3%) Frame = +1 Query: 4435 QNRVRNPSMGGGYSQQGFRXXXXXXXXXXXXXXXXX---YGYMQPGAYPGAPPQYSMSQP 4605 +NR+RNP+M GGY QQG++ Y Y QPG+YPG PQY+MSQP Sbjct: 301 ENRIRNPAMAGGYPQQGYQARPPSGWGAPPGAPPMQQPGYSYAQPGSYPGPSPQYNMSQP 360 Query: 4606 PYTGYPPQATSTGWDXXXXXXXXXXXXXXGYDYYNQQP---QQPSTGGASAPADNTGYNY 4776 Y GY Q +TGWD GYDYY QQ QQ + GG S PADN+GYNY Sbjct: 361 AYAGYS-QPNATGWDQTAAPPSQQTTPGSGYDYYGQQQTQQQQQAHGGPSGPADNSGYNY 419 Query: 4777 NQAPASNXXXXXXXXXXXXXXXXXXXXXXXXTQDGYGSGYHAPAPQAGYGQPQANPQSGY 4956 NQ PAS QDGYG GYHAPAPQ GYGQPQ P GY Sbjct: 420 NQPPASGYNQQGQGYP----------------QDGYGGGYHAPAPQPGYGQPQPIP--GY 461 Query: 4957 DQTQGYNSAPTYATGVNXXXXXXXXXXXXXXXT-QVTPSVQPAVGAQQGYSTQQPN-TPP 5130 DQ QGYNSA Y N T Q PSVQP+ QQGY+TQQP+ +P Sbjct: 462 DQQQGYNSATGYGNVANPTQEGHTTSYGAQGETGQAPPSVQPSAIGQQGYNTQQPSPSPA 521 Query: 5131 SYPTQAVQS---GYPPSSQPGYGAQMPATSGYGQSAPPTQPSYGPPQGQKAPSSQAIYGQ 5301 SYP Q G PP+SQ G+G+Q PA SGY +YGPPQ QKAP++ +YGQ Sbjct: 522 SYPPQGSNQPAYGMPPTSQTGFGSQPPAQSGY-------TTNYGPPQAQKAPANPPVYGQ 574 Query: 5302 TQP-PSSQAGYTQPATAQPVYAHAQSTPTHSGSAQSDSGHHRPPASGFGSAAPQAGYVQP 5478 TQ PS+Q GY QPA QP Y H+Q P SG AQ+DS R S +G+AA Q GY P Sbjct: 575 TQQSPSAQGGYAQPAPVQPGYPHSQQPPAQSGYAQTDSSSQRAAPSSYGTAAGQPGYGGP 634 Query: 5479 Q-YGVPLTSQPGYGXXXXXTYGDSYAGAYTQPPVFSGDGT 5595 Y P +Q GYG Y SY G Y+QPP+++ D T Sbjct: 635 SAYSAPTVTQAGYG--QQPPYSGSYGGGYSQPPMYAADAT 672 Score = 229 bits (585), Expect(2) = 1e-81 Identities = 118/146 (80%), Positives = 133/146 (91%) Frame = +2 Query: 626 TIKYLQSQSGGAKIQVTRDMDADPHSLTRLVEIMGTSDQISKAEQLIQEVLAEAESGGSG 805 TIKYLQ QSG AKIQVTRDMDADP+S TRLVE+MGT DQI+KAEQLI +VL+EAE+GGSG Sbjct: 157 TIKYLQLQSG-AKIQVTRDMDADPNSPTRLVELMGTPDQIAKAEQLINDVLSEAEAGGSG 215 Query: 806 LVSKRFTGQPGAEQFSMKVPNNKVGLVIGKGGETIKSMQAKSGARIQLIPLHLPPGDLST 985 +VS+R TGQ G+EQF MKVPNNKVGL+IGKGGETIK+MQA++GARIQ+IPLHLPPGD S Sbjct: 216 IVSRRLTGQAGSEQFVMKVPNNKVGLIIGKGGETIKNMQARTGARIQVIPLHLPPGDTSM 275 Query: 986 ERTVYIDGTEQQIEYAKQLVNEVISE 1063 ERTV IDGT +QIE AKQLVNEVISE Sbjct: 276 ERTVQIDGTSEQIESAKQLVNEVISE 301 Score = 103 bits (258), Expect(2) = 1e-81 Identities = 83/198 (41%), Positives = 94/198 (47%), Gaps = 19/198 (9%) Frame = +1 Query: 40 MAEELQYSS------KRKYEDXXXXXXXXXXXXXXXXXFSAPISPXXXXXXXXXXXXXXX 201 MAEE+QYSS KRKYED FSAPIS Sbjct: 1 MAEEVQYSSGTDATNKRKYEDQTTPSQPSTRRPTG---FSAPISTPSPDSSHAPPSYNS- 56 Query: 202 XXXXXXXXXXXXXXXXXXXXXXXXXXXVPPPAMDQFQLAKQRAQEIASRLYNNT--TEPK 375 VPPPA D+ QLAKQRAQEIA+RL++N TE K Sbjct: 57 ---------------------------VPPPA-DEIQLAKQRAQEIAARLFSNASNTEAK 88 Query: 376 RPRTESN---GSDDSNPNDYGSGYHQAS--------SALPVPYGFQGGTANGSSKKIEIP 522 RPR E+ G DS + S SA+PV YG+QG +SKKI+IP Sbjct: 89 RPRVENGAGAGGFDSGDKGFSSAPSDVGQKPMISTPSAIPVSYGYQG-----TSKKIDIP 143 Query: 523 NGRVGVIIGKGGETIKYL 576 NGRVGVIIGKGGETIKYL Sbjct: 144 NGRVGVIIGKGGETIKYL 161 Score = 63.5 bits (153), Expect = 7e-07 Identities = 33/68 (48%), Positives = 47/68 (69%) Frame = +2 Query: 860 VPNNKVGLVIGKGGETIKSMQAKSGARIQLIPLHLPPGDLSTERTVYIDGTEQQIEYAKQ 1039 +PN +VG++IGKGGETIK +Q +SGA+IQ + + S R V + GT QI A+Q Sbjct: 142 IPNGRVGVIIGKGGETIKYLQLQSGAKIQ-VTRDMDADPNSPTRLVELMGTPDQIAKAEQ 200 Query: 1040 LVNEVISE 1063 L+N+V+SE Sbjct: 201 LINDVLSE 208 >ref|XP_004142921.1| PREDICTED: uncharacterized protein LOC101216803 [Cucumis sativus] gi|449494409|ref|XP_004159539.1| PREDICTED: uncharacterized LOC101216803 [Cucumis sativus] Length = 694 Score = 229 bits (584), Expect(2) = 8e-82 Identities = 117/146 (80%), Positives = 133/146 (91%) Frame = +2 Query: 626 TIKYLQSQSGGAKIQVTRDMDADPHSLTRLVEIMGTSDQISKAEQLIQEVLAEAESGGSG 805 TIKYLQ QSG AKIQVTRDMDADP+S TR+VE+MGT DQI+KAEQLI +VL+EAESGGSG Sbjct: 156 TIKYLQLQSG-AKIQVTRDMDADPNSTTRMVELMGTPDQIAKAEQLINDVLSEAESGGSG 214 Query: 806 LVSKRFTGQPGAEQFSMKVPNNKVGLVIGKGGETIKSMQAKSGARIQLIPLHLPPGDLST 985 +VS+R TG G+EQF MK+PNNKVGLVIGKGGETIKSMQA++GARIQ+IPLHLPPGD ST Sbjct: 215 IVSRRLTGPSGSEQFVMKIPNNKVGLVIGKGGETIKSMQARTGARIQVIPLHLPPGDTST 274 Query: 986 ERTVYIDGTEQQIEYAKQLVNEVISE 1063 ERT+ IDG+ +QIE AKQLVNEVISE Sbjct: 275 ERTLQIDGSSEQIESAKQLVNEVISE 300 Score = 105 bits (261), Expect(2) = 8e-82 Identities = 63/115 (54%), Positives = 72/115 (62%), Gaps = 19/115 (16%) Frame = +1 Query: 289 PPAMDQFQLAKQRAQEIASRLYNNT------------TEPKRPRTESNGSDDSNPNDYGS 432 PP MD+ QLAKQRAQEIASRL ++ + KRPR E+ G DS + S Sbjct: 51 PPPMDEIQLAKQRAQEIASRLIISSGGVGAGAGPGVGADVKRPRVENGGGYDSYDKGFSS 110 Query: 433 G-------YHQASSALPVPYGFQGGTANGSSKKIEIPNGRVGVIIGKGGETIKYL 576 G + A SA+P+ YGFQG SSKKIEIPNGRVGVIIGKGGETIKYL Sbjct: 111 GPDLKPHMSNSAPSAIPISYGFQG-----SSKKIEIPNGRVGVIIGKGGETIKYL 160 Score = 226 bits (577), Expect = 5e-56 Identities = 159/414 (38%), Positives = 194/414 (46%), Gaps = 17/414 (4%) Frame = +1 Query: 4435 QNRVRNPSMGGGYSQQGF--RXXXXXXXXXXXXXXXXXYGYMQPGAYPGAPPQYSMSQPP 4608 +NR RN M GGY+QQG+ R YGY Q G Y QY++SQPP Sbjct: 300 ENRARNSGMSGGYNQQGYQARPPSSWGPPGAPPMQQPNYGYGQQGGYSAPSSQYNISQPP 359 Query: 4609 YTGYPPQAT---STGWDXXXXXXXXXXXXXXGYDYYNQQ-PQQPST-GGASAPADNTGYN 4773 Y GY A+ ++ WD GYDYY QQ PQQ T GG A DN+GY+ Sbjct: 360 YQGYSQPASGGYASNWDQSTVPPNQPATQGSGYDYYGQQAPQQQQTAGGPGATGDNSGYS 419 Query: 4774 YNQAPASNXXXXXXXXXXXXXXXXXXXXXXXXTQDGYGSGYHAPAPQAGYGQPQANPQSG 4953 Y Q PA+ +QDGYG YH APQ+GYGQP Sbjct: 420 YGQPPATT------------------YNQQGYSQDGYGGNYH--APQSGYGQPPT----- 454 Query: 4954 YDQTQGYNSAPTYATGVNXXXXXXXXXXXXXXXTQVTP--SVQPAVGAQQGYS-TQQPNT 5124 YDQ QGY+S Y N +Q P + QP+ +QQGYS QQP+ Sbjct: 455 YDQ-QGYSSTTNYGNVANATQDGLNSYGSQGDSSQTVPPAAPQPSSVSQQGYSANQQPSP 513 Query: 5125 PPSYPTQAVQSGYPPSSQPGYGAQMPATSGYGQSAPPTQ----PSYGPPQGQK-APSSQA 5289 P YPP SQ GYG P+ +GYG + P Q +YG PQ QK P++ Sbjct: 514 NP--------GSYPPPSQSGYGMTAPSQTGYG-NQPAAQAAYGAAYGAPQTQKQPPTNPP 564 Query: 5290 IYGQ-TQPPSSQAGYTQPATAQPVYAHAQSTPTHSGSAQSDSGHHRPPASGFGSAAPQAG 5466 YGQ TQ PS+ +GY QPA Y+ Q P SG Q DS R P S +G+AA Q G Sbjct: 565 AYGQSTQSPSTASGYGQPAGLPSGYSSTQ--PPASGYTQPDSASQRAPPSSYGTAAAQPG 622 Query: 5467 YVQPQY-GVPLTSQPGYGXXXXXTYGDSYAGAYTQPPVFSGDGTVGSNSHGTYD 5625 + P Y G P T+Q YG YG SY Y QP +S +G G + G YD Sbjct: 623 FAPPPYGGAPPTNQSAYG-QAPPPYGGSYGAGYPQPH-YSSEGNAGGATRGGYD 674 Score = 66.6 bits (161), Expect = 8e-08 Identities = 34/70 (48%), Positives = 50/70 (71%) Frame = +2 Query: 854 MKVPNNKVGLVIGKGGETIKSMQAKSGARIQLIPLHLPPGDLSTERTVYIDGTEQQIEYA 1033 +++PN +VG++IGKGGETIK +Q +SGA+IQ + + ST R V + GT QI A Sbjct: 139 IEIPNGRVGVIIGKGGETIKYLQLQSGAKIQ-VTRDMDADPNSTTRMVELMGTPDQIAKA 197 Query: 1034 KQLVNEVISE 1063 +QL+N+V+SE Sbjct: 198 EQLINDVLSE 207 >emb|CBI20623.3| unnamed protein product [Vitis vinifera] Length = 479 Score = 229 bits (585), Expect(2) = 1e-81 Identities = 118/146 (80%), Positives = 133/146 (91%) Frame = +2 Query: 626 TIKYLQSQSGGAKIQVTRDMDADPHSLTRLVEIMGTSDQISKAEQLIQEVLAEAESGGSG 805 TIKYLQ QSG AKIQVTRDMDADP+S TRLVE+MGT DQI+KAEQLI +VL+EAE+GGSG Sbjct: 157 TIKYLQLQSG-AKIQVTRDMDADPNSPTRLVELMGTPDQIAKAEQLINDVLSEAEAGGSG 215 Query: 806 LVSKRFTGQPGAEQFSMKVPNNKVGLVIGKGGETIKSMQAKSGARIQLIPLHLPPGDLST 985 +VS+R TGQ G+EQF MKVPNNKVGL+IGKGGETIK+MQA++GARIQ+IPLHLPPGD S Sbjct: 216 IVSRRLTGQAGSEQFVMKVPNNKVGLIIGKGGETIKNMQARTGARIQVIPLHLPPGDTSM 275 Query: 986 ERTVYIDGTEQQIEYAKQLVNEVISE 1063 ERTV IDGT +QIE AKQLVNEVISE Sbjct: 276 ERTVQIDGTSEQIESAKQLVNEVISE 301 Score = 103 bits (258), Expect(2) = 1e-81 Identities = 83/198 (41%), Positives = 94/198 (47%), Gaps = 19/198 (9%) Frame = +1 Query: 40 MAEELQYSS------KRKYEDXXXXXXXXXXXXXXXXXFSAPISPXXXXXXXXXXXXXXX 201 MAEE+QYSS KRKYED FSAPIS Sbjct: 1 MAEEVQYSSGTDATNKRKYEDQTTPSQPSTRRPTG---FSAPISTPSPDSSHAPPSYNS- 56 Query: 202 XXXXXXXXXXXXXXXXXXXXXXXXXXXVPPPAMDQFQLAKQRAQEIASRLYNNT--TEPK 375 VPPPA D+ QLAKQRAQEIA+RL++N TE K Sbjct: 57 ---------------------------VPPPA-DEIQLAKQRAQEIAARLFSNASNTEAK 88 Query: 376 RPRTESN---GSDDSNPNDYGSGYHQAS--------SALPVPYGFQGGTANGSSKKIEIP 522 RPR E+ G DS + S SA+PV YG+QG +SKKI+IP Sbjct: 89 RPRVENGAGAGGFDSGDKGFSSAPSDVGQKPMISTPSAIPVSYGYQG-----TSKKIDIP 143 Query: 523 NGRVGVIIGKGGETIKYL 576 NGRVGVIIGKGGETIKYL Sbjct: 144 NGRVGVIIGKGGETIKYL 161 Score = 119 bits (299), Expect = 8e-24 Identities = 75/197 (38%), Positives = 85/197 (43%), Gaps = 6/197 (3%) Frame = +1 Query: 4435 QNRVRNPSMGGGYSQQGFRXXXXXXXXXXXXXXXXX---YGYMQPGAYPGAPPQYSMSQP 4605 +NR+RNP+M GGY QQG++ Y Y QPG+YPG PQY+MSQP Sbjct: 301 ENRIRNPAMAGGYPQQGYQARPPSGWGAPPGAPPMQQPGYSYAQPGSYPGPSPQYNMSQP 360 Query: 4606 PYTGYPPQATSTGWDXXXXXXXXXXXXXXGYDYYNQ---QPQQPSTGGASAPADNTGYNY 4776 Y GY Q +TGWD GYDYY Q Q QQ + GG S PADN+GYNY Sbjct: 361 AYAGY-SQPNATGWDQTAAPPSQQTTPGSGYDYYGQQQTQQQQQAHGGPSGPADNSGYNY 419 Query: 4777 NQAPASNXXXXXXXXXXXXXXXXXXXXXXXXTQDGYGSGYHAPAPQAGYGQPQANPQSGY 4956 NQ PAS GY Q GY Sbjct: 420 NQPPAS-----------------------------------------GYNQ----QGQGY 434 Query: 4957 DQTQGYNSAPTYATGVN 5007 DQ QGYNSA Y N Sbjct: 435 DQQQGYNSATGYGNVAN 451 Score = 63.5 bits (153), Expect = 7e-07 Identities = 33/68 (48%), Positives = 47/68 (69%) Frame = +2 Query: 860 VPNNKVGLVIGKGGETIKSMQAKSGARIQLIPLHLPPGDLSTERTVYIDGTEQQIEYAKQ 1039 +PN +VG++IGKGGETIK +Q +SGA+IQ + + S R V + GT QI A+Q Sbjct: 142 IPNGRVGVIIGKGGETIKYLQLQSGAKIQ-VTRDMDADPNSPTRLVELMGTPDQIAKAEQ 200 Query: 1040 LVNEVISE 1063 L+N+V+SE Sbjct: 201 LINDVLSE 208 >emb|CAN67283.1| hypothetical protein VITISV_021595 [Vitis vinifera] Length = 382 Score = 306 bits (785), Expect = 3e-80 Identities = 179/392 (45%), Positives = 207/392 (52%), Gaps = 13/392 (3%) Frame = +1 Query: 4459 MGGGYSQQGFRXXXXXXXXXXXXXXXXX---YGYMQPGAYPGAPPQYSMSQPPYTGYPPQ 4629 M GGY QQG++ Y Y QPG+YPG PQY+MSQP Y GY Q Sbjct: 1 MAGGYPQQGYQARPPSGWGAPPGAPPMQQPGYSYAQPGSYPGPSPQYNMSQPAYAGYS-Q 59 Query: 4630 ATSTGWDXXXXXXXXXXXXXXGYDYYNQQP---QQPSTGGASAPADNTGYNYNQAPASNX 4800 +TGWD GYDYY QQ QQ + GG S PADN+GYNYNQ PAS Sbjct: 60 PNATGWDQTAAPPSQQTTPGSGYDYYGQQQTQQQQQAHGGPSGPADNSGYNYNQPPASGY 119 Query: 4801 XXXXXXXXXXXXXXXXXXXXXXXTQDGYGSGYHAPAPQAGYGQPQANPQSGYDQTQGYNS 4980 QDGYG GYHAPAPQ GYGQPQ P GYDQ QGYNS Sbjct: 120 NQQGQGYP----------------QDGYGGGYHAPAPQPGYGQPQPIP--GYDQQQGYNS 161 Query: 4981 APTYATGVNXXXXXXXXXXXXXXXT-QVTPSVQPAVGAQQGYSTQQPN-TPPSYPTQAVQ 5154 A Y N T Q PSVQP+ QQGY+TQQP+ +P SYP Q Sbjct: 162 ATGYGNVANPTQEGHTTSYGAQGETGQAPPSVQPSAIGQQGYNTQQPSPSPASYPPQGSN 221 Query: 5155 S---GYPPSSQPGYGAQMPATSGYGQSAPPTQPSYGPPQGQKAPSSQAIYGQTQP-PSSQ 5322 G PP+SQ G+G+Q PA SGY +YGPPQ QKAP++ +YGQTQ PS+Q Sbjct: 222 QPAYGMPPTSQTGFGSQPPAQSGY-------TTNYGPPQAQKAPANPPVYGQTQQSPSAQ 274 Query: 5323 AGYTQPATAQPVYAHAQSTPTHSGSAQSDSGHHRPPASGFGSAAPQAGYVQPQ-YGVPLT 5499 GY QPA QP Y H+Q P SG AQ+DS R S +G+AA Q GY P Y P Sbjct: 275 GGYAQPAPVQPGYPHSQQPPAQSGYAQTDSSSQRAAPSSYGTAAGQPGYGGPSAYSAPTV 334 Query: 5500 SQPGYGXXXXXTYGDSYAGAYTQPPVFSGDGT 5595 +Q GYG Y SY G Y+QPP+++ D T Sbjct: 335 TQAGYG--QQPPYSGSYGGGYSQPPMYAADAT 364 >ref|XP_002516463.1| nucleic acid binding protein, putative [Ricinus communis] gi|223544283|gb|EEF45804.1| nucleic acid binding protein, putative [Ricinus communis] Length = 306 Score = 221 bits (562), Expect(2) = 7e-78 Identities = 112/146 (76%), Positives = 130/146 (89%) Frame = +2 Query: 626 TIKYLQSQSGGAKIQVTRDMDADPHSLTRLVEIMGTSDQISKAEQLIQEVLAEAESGGSG 805 TIKYLQ QSG AKIQVTRDMDADP+S TR+VE+MG DQI+KAEQLI EVLAEA+ GGSG Sbjct: 161 TIKYLQIQSG-AKIQVTRDMDADPNSPTRMVELMGNPDQIAKAEQLISEVLAEADVGGSG 219 Query: 806 LVSKRFTGQPGAEQFSMKVPNNKVGLVIGKGGETIKSMQAKSGARIQLIPLHLPPGDLST 985 VS+RFTGQ G+E F MK+PNNKVGLVIGKGG++IK+MQA++GARIQ+IPLHLPPGD ST Sbjct: 220 TVSRRFTGQGGSEHFVMKIPNNKVGLVIGKGGDSIKNMQARTGARIQVIPLHLPPGDTST 279 Query: 986 ERTVYIDGTEQQIEYAKQLVNEVISE 1063 +R V+I+GT +QIE AKQLVNE ISE Sbjct: 280 DRNVHIEGTSEQIELAKQLVNEAISE 305 Score = 100 bits (249), Expect(2) = 7e-78 Identities = 61/112 (54%), Positives = 75/112 (66%), Gaps = 16/112 (14%) Frame = +1 Query: 289 PPAMDQFQLAKQRAQEIASRLYNNTT----EPKRPRTESNG-----SDDSN-------PN 420 PP +D+ Q+AKQ+AQEIA+RL + + KRPR ++NG S+D+N PN Sbjct: 57 PPPVDEIQMAKQKAQEIAARLLSGAAGGGGDIKRPRVDNNGASGFDSNDNNKGFSSAPPN 116 Query: 421 DYGSGYHQASSALPVPYGFQGGTANGSSKKIEIPNGRVGVIIGKGGETIKYL 576 D S + A SA+PV YG G+ SSKKIEIPNGRVGVIIGKGGETIKYL Sbjct: 117 DLKSLSNSAPSAIPVSYGTYLGS---SSKKIEIPNGRVGVIIGKGGETIKYL 165 Score = 62.0 bits (149), Expect = 2e-06 Identities = 32/76 (42%), Positives = 50/76 (65%) Frame = +2 Query: 836 GAEQFSMKVPNNKVGLVIGKGGETIKSMQAKSGARIQLIPLHLPPGDLSTERTVYIDGTE 1015 G+ +++PN +VG++IGKGGETIK +Q +SGA+IQ + + S R V + G Sbjct: 138 GSSSKKIEIPNGRVGVIIGKGGETIKYLQIQSGAKIQ-VTRDMDADPNSPTRMVELMGNP 196 Query: 1016 QQIEYAKQLVNEVISE 1063 QI A+QL++EV++E Sbjct: 197 DQIAKAEQLISEVLAE 212