BLASTX 2.2.25 [Feb-01-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Akebia24_contig00018788
         (289 letters)

Database: ./nr 
           38,876,450 sequences; 13,856,398,315 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

ref|XP_007201726.1| hypothetical protein PRUPE_ppa003014mg [Prun...   130   2e-28
ref|XP_007042495.1| Pten 2 [Theobroma cacao] gi|508706430|gb|EOX...   123   2e-26
ref|XP_002298741.2| hypothetical protein POPTR_0001s30940g [Popu...   119   6e-25
ref|XP_006487024.1| PREDICTED: formin-like protein 5-like isofor...   115   8e-24
emb|CBI40281.3| unnamed protein product [Vitis vinifera]              114   1e-23
ref|XP_002285306.1| PREDICTED: uncharacterized protein LOC100246...   114   1e-23
gb|EXC17260.1| Phosphatidylinositol-3,4,5-trisphosphate 3-phosph...   112   4e-23
ref|XP_004230750.1| PREDICTED: uncharacterized protein LOC101255...   112   7e-23
ref|XP_004230749.1| PREDICTED: uncharacterized protein LOC101255...   112   7e-23
ref|XP_006422958.1| hypothetical protein CICLE_v10028040mg [Citr...   111   9e-23
ref|XP_004304029.1| PREDICTED: cyclin-G-associated kinase-like [...   110   2e-22
gb|ADV04056.1| tyrosine phosphatase [Hevea brasiliensis]              110   2e-22
ref|XP_002518704.1| phosphoprotein phosphatase, putative [Ricinu...   110   3e-22
ref|XP_004159902.1| PREDICTED: phosphatidylinositol 3,4,5-trisph...   105   5e-21
ref|XP_004136966.1| PREDICTED: phosphatidylinositol 3,4,5-trisph...   105   5e-21
ref|NP_188573.1| phosphatase PTEN2 [Arabidopsis thaliana] gi|119...   103   2e-20
gb|AAO13749.1|AF268257_1 PTEN-like protein [Arabidopsis thaliana]     103   2e-20
ref|XP_003555950.1| PREDICTED: phosphatidylinositol 3,4,5-trisph...   103   3e-20
ref|XP_006406503.1| hypothetical protein EUTSA_v10020332mg [Eutr...   102   4e-20
ref|XP_006297600.1| hypothetical protein CARUB_v10013622mg [Caps...   102   7e-20

>ref|XP_007201726.1| hypothetical protein PRUPE_ppa003014mg [Prunus persica]
           gi|462397126|gb|EMJ02925.1| hypothetical protein
           PRUPE_ppa003014mg [Prunus persica]
          Length = 612

 Score =  130 bits (327), Expect = 2e-28
 Identities = 62/95 (65%), Positives = 73/95 (76%)
 Frame = -1

Query: 286 ENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPAT 107
           ENRK+L  +DLDGFDKRKLPSPGFQVEVVL+DY+G +PT P TE ++KKP+ESS TNP++
Sbjct: 419 ENRKVLTNNDLDGFDKRKLPSPGFQVEVVLVDYNGNVPTAPNTETSTKKPDESSGTNPSS 478

Query: 106 SDXXXXXXXXNKGSGTSDKDDVFSDSETEESGSSK 2
            D        +K  G  DKDDVFSDSE EES SSK
Sbjct: 479 DDGGTAAPQESKSPGNQDKDDVFSDSEAEESSSSK 513


>ref|XP_007042495.1| Pten 2 [Theobroma cacao] gi|508706430|gb|EOX98326.1| Pten 2
           [Theobroma cacao]
          Length = 609

 Score =  123 bits (309), Expect = 2e-26
 Identities = 63/96 (65%), Positives = 75/96 (78%)
 Frame = -1

Query: 289 MENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPA 110
           +ENRKIL TSDLD FDKRKLPSPGFQVEVVL+DY+GT+ T+P  E+ + KP+ESS +N A
Sbjct: 415 IENRKILNTSDLDWFDKRKLPSPGFQVEVVLVDYNGTVLTKPQPENAATKPDESSGSNAA 474

Query: 109 TSDXXXXXXXXNKGSGTSDKDDVFSDSETEESGSSK 2
           ++D        NK  G +DKDDVFSDSE EESGSSK
Sbjct: 475 SADGGAASSNQNKDPGHNDKDDVFSDSEAEESGSSK 510


>ref|XP_002298741.2| hypothetical protein POPTR_0001s30940g [Populus trichocarpa]
           gi|550348589|gb|EEE83546.2| hypothetical protein
           POPTR_0001s30940g [Populus trichocarpa]
          Length = 615

 Score =  119 bits (297), Expect = 6e-25
 Identities = 63/96 (65%), Positives = 70/96 (72%)
 Frame = -1

Query: 289 MENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPA 110
           MENRKIL TSD+DGFDKRKLPSPGFQVEVVL+DYDGT+ TR   E   KK +E S T  A
Sbjct: 422 MENRKILNTSDIDGFDKRKLPSPGFQVEVVLVDYDGTVSTRSNIETAVKKSDEGSSTALA 481

Query: 109 TSDXXXXXXXXNKGSGTSDKDDVFSDSETEESGSSK 2
           + D        NK S ++DKDDVFSDSE EES SSK
Sbjct: 482 SVDAGTTAPNQNKDSASNDKDDVFSDSEAEESVSSK 517


>ref|XP_006487024.1| PREDICTED: formin-like protein 5-like isoform X1 [Citrus sinensis]
           gi|568867399|ref|XP_006487025.1| PREDICTED: formin-like
           protein 5-like isoform X2 [Citrus sinensis]
          Length = 611

 Score =  115 bits (287), Expect = 8e-24
 Identities = 56/96 (58%), Positives = 71/96 (73%)
 Frame = -1

Query: 289 MENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPA 110
           MENRK+L T DLDGFDKRKLPSPGFQVEVVL DY+G +     +E  +KKP+E+S + PA
Sbjct: 420 MENRKVLNTGDLDGFDKRKLPSPGFQVEVVLADYNGPVRAAANSETVAKKPDETSGSAPA 479

Query: 109 TSDXXXXXXXXNKGSGTSDKDDVFSDSETEESGSSK 2
           +          +KGSG +DKDDVFSD+E+EE+GS +
Sbjct: 480 SVGQGLDASKESKGSGNNDKDDVFSDNESEEAGSKR 515


>emb|CBI40281.3| unnamed protein product [Vitis vinifera]
          Length = 548

 Score =  114 bits (286), Expect = 1e-23
 Identities = 59/96 (61%), Positives = 67/96 (69%)
 Frame = -1

Query: 289 MENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPA 110
           MENRK+L   DLDGFDKRKLPSPGFQVEVVLID+DG++P  P TE   KK +  S T  A
Sbjct: 415 MENRKVLNPDDLDGFDKRKLPSPGFQVEVVLIDHDGSVPPAPKTETDVKKSDGVSGTGSA 474

Query: 109 TSDXXXXXXXXNKGSGTSDKDDVFSDSETEESGSSK 2
           + D        +K  G+ DKDDVFSD E EESGSSK
Sbjct: 475 SVDGANATPNPSKDPGSKDKDDVFSDGEVEESGSSK 510


>ref|XP_002285306.1| PREDICTED: uncharacterized protein LOC100246943 [Vitis vinifera]
          Length = 607

 Score =  114 bits (286), Expect = 1e-23
 Identities = 59/96 (61%), Positives = 67/96 (69%)
 Frame = -1

Query: 289 MENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPA 110
           MENRK+L   DLDGFDKRKLPSPGFQVEVVLID+DG++P  P TE   KK +  S T  A
Sbjct: 415 MENRKVLNPDDLDGFDKRKLPSPGFQVEVVLIDHDGSVPPAPKTETDVKKSDGVSGTGSA 474

Query: 109 TSDXXXXXXXXNKGSGTSDKDDVFSDSETEESGSSK 2
           + D        +K  G+ DKDDVFSD E EESGSSK
Sbjct: 475 SVDGANATPNPSKDPGSKDKDDVFSDGEVEESGSSK 510


>gb|EXC17260.1| Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and
           dual-specificity protein phosphatase PTEN [Morus
           notabilis]
          Length = 607

 Score =  112 bits (281), Expect = 4e-23
 Identities = 57/95 (60%), Positives = 70/95 (73%)
 Frame = -1

Query: 286 ENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPAT 107
           ENRK+L T+DLDGFDKRKLPSPGFQVEVVL+DY+GT+P  P  E T+K  +E S++  +T
Sbjct: 416 ENRKLLSTADLDGFDKRKLPSPGFQVEVVLVDYNGTVPKTPNAESTTKISDEGSQSALST 475

Query: 106 SDXXXXXXXXNKGSGTSDKDDVFSDSETEESGSSK 2
            +         K SGT +KDDVFSDSE E+ GSSK
Sbjct: 476 VEGAPAALKPTKDSGTQEKDDVFSDSEAED-GSSK 509


>ref|XP_004230750.1| PREDICTED: uncharacterized protein LOC101255438 isoform 2 [Solanum
           lycopersicum] gi|460369812|ref|XP_004230751.1|
           PREDICTED: uncharacterized protein LOC101255438 isoform
           3 [Solanum lycopersicum]
          Length = 619

 Score =  112 bits (279), Expect = 7e-23
 Identities = 57/102 (55%), Positives = 69/102 (67%), Gaps = 6/102 (5%)
 Frame = -1

Query: 289 MENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPA 110
           +ENRK+L+TSDLDGFDKRKLPSPGFQVEVVL DYD  +P RP +E  +K+  +SS  NPA
Sbjct: 421 IENRKVLMTSDLDGFDKRKLPSPGFQVEVVLADYDAALPARPQSETATKESADSSSANPA 480

Query: 109 TSDXXXXXXXXNKGS------GTSDKDDVFSDSETEESGSSK 2
                        G+      G +DKDDVFSD+E+EE G SK
Sbjct: 481 PVSNPTSGSEPADGTNVNQQPGNNDKDDVFSDNESEEPGMSK 522


>ref|XP_004230749.1| PREDICTED: uncharacterized protein LOC101255438 isoform 1 [Solanum
           lycopersicum]
          Length = 637

 Score =  112 bits (279), Expect = 7e-23
 Identities = 57/102 (55%), Positives = 69/102 (67%), Gaps = 6/102 (5%)
 Frame = -1

Query: 289 MENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPA 110
           +ENRK+L+TSDLDGFDKRKLPSPGFQVEVVL DYD  +P RP +E  +K+  +SS  NPA
Sbjct: 439 IENRKVLMTSDLDGFDKRKLPSPGFQVEVVLADYDAALPARPQSETATKESADSSSANPA 498

Query: 109 TSDXXXXXXXXNKGS------GTSDKDDVFSDSETEESGSSK 2
                        G+      G +DKDDVFSD+E+EE G SK
Sbjct: 499 PVSNPTSGSEPADGTNVNQQPGNNDKDDVFSDNESEEPGMSK 540


>ref|XP_006422958.1| hypothetical protein CICLE_v10028040mg [Citrus clementina]
           gi|567860610|ref|XP_006422959.1| hypothetical protein
           CICLE_v10028040mg [Citrus clementina]
           gi|557524892|gb|ESR36198.1| hypothetical protein
           CICLE_v10028040mg [Citrus clementina]
           gi|557524893|gb|ESR36199.1| hypothetical protein
           CICLE_v10028040mg [Citrus clementina]
          Length = 611

 Score =  111 bits (278), Expect = 9e-23
 Identities = 55/94 (58%), Positives = 69/94 (73%)
 Frame = -1

Query: 289 MENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPA 110
           MENRK+L T DLDGFDKRKLPSPGFQVEVVL DY+G +     +E  +KKP+E+S + PA
Sbjct: 420 MENRKVLNTGDLDGFDKRKLPSPGFQVEVVLADYNGPVRAAANSETVAKKPDETSGSAPA 479

Query: 109 TSDXXXXXXXXNKGSGTSDKDDVFSDSETEESGS 8
           +          +K SG +DKDDVFSD+E+EE+GS
Sbjct: 480 SVGQGLDASKESKDSGNNDKDDVFSDNESEEAGS 513


>ref|XP_004304029.1| PREDICTED: cyclin-G-associated kinase-like [Fragaria vesca subsp.
           vesca]
          Length = 617

 Score =  110 bits (275), Expect = 2e-22
 Identities = 57/100 (57%), Positives = 70/100 (70%), Gaps = 5/100 (5%)
 Frame = -1

Query: 286 ENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPT--TEDTSKKPNESSETNP 113
           ENRK L T+DLDGFDKRKLPSPGFQ+EVVL+DY+G +P  PT  T+ T+KKP+ESS T P
Sbjct: 419 ENRKTLTTNDLDGFDKRKLPSPGFQLEVVLVDYNGNVPATPTPNTDTTAKKPDESSGTKP 478

Query: 112 ATSDXXXXXXXXNK---GSGTSDKDDVFSDSETEESGSSK 2
            + D                + DKDDVFSD+E +E+GSSK
Sbjct: 479 PSDDSAAATADPPSHHANPESQDKDDVFSDNELDETGSSK 518


>gb|ADV04056.1| tyrosine phosphatase [Hevea brasiliensis]
          Length = 469

 Score =  110 bits (275), Expect = 2e-22
 Identities = 57/97 (58%), Positives = 67/97 (69%), Gaps = 1/97 (1%)
 Frame = -1

Query: 289 MENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPA 110
           MENRK+L T+D+DGFDKRKLPSPGFQVEVVL+DY+G  PT P +E  ++K NE S   PA
Sbjct: 275 MENRKVLNTNDIDGFDKRKLPSPGFQVEVVLVDYNGAAPTGPNSETAAEKSNEGSSAAPA 334

Query: 109 TSDXXXXXXXXNKGSGT-SDKDDVFSDSETEESGSSK 2
             D         +     +DKDDVFSDSE EES SSK
Sbjct: 335 PVDANAAAAAPKQNKDQGNDKDDVFSDSEAEESVSSK 371


>ref|XP_002518704.1| phosphoprotein phosphatase, putative [Ricinus communis]
           gi|223542085|gb|EEF43629.1| phosphoprotein phosphatase,
           putative [Ricinus communis]
          Length = 612

 Score =  110 bits (274), Expect = 3e-22
 Identities = 58/96 (60%), Positives = 67/96 (69%)
 Frame = -1

Query: 289 MENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPA 110
           MENRK+L T+D+DGFDKRKLPSPGFQVEVVL+DY GT P    +E  + K NE S   PA
Sbjct: 420 MENRKVLNTNDIDGFDKRKLPSPGFQVEVVLVDYSGTTPAGTNSETATNKSNEGSSAAPA 479

Query: 109 TSDXXXXXXXXNKGSGTSDKDDVFSDSETEESGSSK 2
             D        NK  G+++KDDVFSDSE EES SSK
Sbjct: 480 -PDPAPAVRSQNKDRGSTEKDDVFSDSEAEESVSSK 514


>ref|XP_004159902.1| PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase
           and dual-specificity protein phosphatase PTEN-like
           [Cucumis sativus]
          Length = 612

 Score =  105 bits (263), Expect = 5e-21
 Identities = 58/95 (61%), Positives = 70/95 (73%)
 Frame = -1

Query: 286 ENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPAT 107
           ENRK+L T+DLDGFDKRKLPSPGFQVEVVL+D      T P  ++T+KK +ESS + P T
Sbjct: 425 ENRKMLYTNDLDGFDKRKLPSPGFQVEVVLVD------TSPNMDNTTKKSDESSGSKPPT 478

Query: 106 SDXXXXXXXXNKGSGTSDKDDVFSDSETEESGSSK 2
           +D        N+ SGT+DKDDVFSDSE+ E GSSK
Sbjct: 479 ADGSEVSENQNRKSGTNDKDDVFSDSES-EGGSSK 512


>ref|XP_004136966.1| PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase
           and dual-specificity protein phosphatase PTEN-like
           [Cucumis sativus]
          Length = 612

 Score =  105 bits (263), Expect = 5e-21
 Identities = 58/95 (61%), Positives = 70/95 (73%)
 Frame = -1

Query: 286 ENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPAT 107
           ENRK+L T+DLDGFDKRKLPSPGFQVEVVL+D      T P  ++T+KK +ESS + P T
Sbjct: 425 ENRKMLYTNDLDGFDKRKLPSPGFQVEVVLVD------TSPNMDNTTKKSDESSGSKPPT 478

Query: 106 SDXXXXXXXXNKGSGTSDKDDVFSDSETEESGSSK 2
           +D        N+ SGT+DKDDVFSDSE+ E GSSK
Sbjct: 479 ADGSEVSENQNRKSGTNDKDDVFSDSES-EGGSSK 512


>ref|NP_188573.1| phosphatase PTEN2 [Arabidopsis thaliana]
           gi|11994464|dbj|BAB02466.1| tyrosine phosphatase-like
           protein [Arabidopsis thaliana]
           gi|17979063|gb|AAL49799.1| putative tyrosine phosphatase
           [Arabidopsis thaliana] gi|332642717|gb|AEE76238.1|
           protein phosphatase and tensin homolog deleted on
           chromosome ten 2A [Arabidopsis thaliana]
          Length = 611

 Score =  103 bits (258), Expect = 2e-20
 Identities = 53/96 (55%), Positives = 65/96 (67%)
 Frame = -1

Query: 289 MENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPA 110
           MENR IL TS+LDGFDKRKLPSPGF VEVVL D + TIPT P++E  SK P E+S  N +
Sbjct: 425 MENRVILKTSELDGFDKRKLPSPGFMVEVVLADINATIPTNPSSETASKTPEETSAANSS 484

Query: 109 TSDXXXXXXXXNKGSGTSDKDDVFSDSETEESGSSK 2
             D        +K +   DKDDVFSD+E + +G +K
Sbjct: 485 PVDGSASVPGPDKETENPDKDDVFSDNEGDSTGPTK 520


>gb|AAO13749.1|AF268257_1 PTEN-like protein [Arabidopsis thaliana]
          Length = 611

 Score =  103 bits (258), Expect = 2e-20
 Identities = 53/96 (55%), Positives = 65/96 (67%)
 Frame = -1

Query: 289 MENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPA 110
           MENR IL TS+LDGFDKRKLPSPGF VEVVL D + TIPT P++E  SK P E+S  N +
Sbjct: 425 MENRVILKTSELDGFDKRKLPSPGFMVEVVLADINATIPTNPSSETASKTPEETSAANSS 484

Query: 109 TSDXXXXXXXXNKGSGTSDKDDVFSDSETEESGSSK 2
             D        +K +   DKDDVFSD+E + +G +K
Sbjct: 485 PVDGSASVPGPDKETENPDKDDVFSDNEGDSTGPTK 520


>ref|XP_003555950.1| PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase
           and dual-specificity protein phosphatase PTEN-like
           isoform X1 [Glycine max]
           gi|571566754|ref|XP_006605967.1| PREDICTED:
           phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase
           and dual-specificity protein phosphatase PTEN-like
           isoform X2 [Glycine max]
          Length = 623

 Score =  103 bits (256), Expect = 3e-20
 Identities = 58/99 (58%), Positives = 68/99 (68%), Gaps = 4/99 (4%)
 Frame = -1

Query: 286 ENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPAT 107
           ENRK+L TSDLDGFDKRKLPSPGF VEVVL+DY+G   T   TE T+KK +ESS  NPA+
Sbjct: 428 ENRKVLNTSDLDGFDKRKLPSPGFMVEVVLVDYNGNDVT-SKTETTTKKSDESSSNNPAS 486

Query: 106 S----DXXXXXXXXNKGSGTSDKDDVFSDSETEESGSSK 2
           S             +K S + DKDDVFSD E E+S SS+
Sbjct: 487 SAPVERSTTPAQNADKESDSHDKDDVFSDGEAEQSASSR 525


>ref|XP_006406503.1| hypothetical protein EUTSA_v10020332mg [Eutrema salsugineum]
           gi|557107649|gb|ESQ47956.1| hypothetical protein
           EUTSA_v10020332mg [Eutrema salsugineum]
          Length = 603

 Score =  102 bits (255), Expect = 4e-20
 Identities = 52/96 (54%), Positives = 66/96 (68%)
 Frame = -1

Query: 289 MENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPA 110
           MENR IL TS+LDGFDKRKLPSPGF VEVVL D + TIP  P++E  SK P+E+S  N +
Sbjct: 418 MENRVILKTSELDGFDKRKLPSPGFMVEVVLADINQTIPANPSSETASKPPDETSAANSS 477

Query: 109 TSDXXXXXXXXNKGSGTSDKDDVFSDSETEESGSSK 2
             +        +K +   DKDDVFSD+ET+ +G +K
Sbjct: 478 PVEGVIPAPGPSKETENPDKDDVFSDNETDSTGPTK 513


>ref|XP_006297600.1| hypothetical protein CARUB_v10013622mg [Capsella rubella]
           gi|482566309|gb|EOA30498.1| hypothetical protein
           CARUB_v10013622mg [Capsella rubella]
          Length = 469

 Score =  102 bits (253), Expect = 7e-20
 Identities = 53/96 (55%), Positives = 64/96 (66%)
 Frame = -1

Query: 289 MENRKILITSDLDGFDKRKLPSPGFQVEVVLIDYDGTIPTRPTTEDTSKKPNESSETNPA 110
           MENR IL TS+LD FDKRKLPSPGF VEVVL D + TIPT P++E  SK P E+S  N +
Sbjct: 283 MENRMILKTSELDAFDKRKLPSPGFMVEVVLADINATIPTNPSSESASKTPEETSAANSS 342

Query: 109 TSDXXXXXXXXNKGSGTSDKDDVFSDSETEESGSSK 2
             D        NK +   DKDDVFSD+E + +G +K
Sbjct: 343 PVDGSASVPGPNKETEDPDKDDVFSDNEGDSTGPTK 378