BLASTX 2.2.25 [Feb-01-2011]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Aconitum21_contig00004547
         (4911 letters)

Database: ./nr 
           23,641,837 sequences; 8,123,359,852 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gb|AAF15293.3| erythrocyte membrane-associated giant protein ant...   194   3e-46
ref|XP_001348162.2| Antigen 332, DBL-like protein [Plasmodium fa...   189   9e-45
ref|XP_002603167.1| hypothetical protein BRAFLDRAFT_63199 [Branc...   184   2e-43
ref|XP_001311646.1| hypothetical protein [Trichomonas vaginalis ...   183   4e-43
ref|XP_001645325.1| hypothetical protein Kpol_1058p4 [Vanderwalt...   182   8e-43

>gb|AAF15293.3| erythrocyte membrane-associated giant protein antigen 332 [Plasmodium
            falciparum]
          Length = 5458

 Score =  194 bits (492), Expect = 3e-46
 Identities = 369/1740 (21%), Positives = 717/1740 (41%), Gaps = 134/1740 (7%)
 Frame = -2

Query: 4889 EEKSINDGREKDKITAGLAIANADKGIGEPV-IEEDVIQDQYTPTIGEEPTKECHEKEKV 4713
            EE S  +G  +D++        A +GI + + + E++++D          T E  E++  
Sbjct: 2758 EEGSATEGIVEDRL--------ATEGIVDDILVTEEIVEDGLA-------TDEFVEQQGS 2802

Query: 4712 IEESKFDANKNIEEPTIEENDHSTTTILEK-TIRDAHENDKAVEDAIIEDVVMDYPKKAI 4536
            I E   D   ++ E  +EE       I+E  ++ +  +N + V + I+E         ++
Sbjct: 2803 IIEEVLDDEGSVTEEIVEEEGSPNEEIVEGVSVIEEDDNIEPVSEEIVEG--------SV 2854

Query: 4535 TEETLKDGLEENKVIEGRNIVG---------ADKDIDDPFIVEDDKCDVTATTRENSIKD 4383
            TEE +K+GLE   +++  +I           +++ +++   + ++  D   +T E+ I++
Sbjct: 2855 TEEMIKEGLENEVILDEDSITEEALEKEGSVSEEIVEEMGSLTEEIVDEERSTSEDMIEE 2914

Query: 4382 GHEEDKVIDE----VKIVEADNDTSEHVREEEVADNSTTTIMEEPTNN-----DHEEDEI 4230
            G   +++I E     ++VE  +   E V E+E+    T  ++EE   N     +H+E+E 
Sbjct: 2915 GSASEEIIQEESQVEEVVEEVSVIDEIVEEDEL---DTKEVVEEIEFNTEEVVEHKEEE- 2970

Query: 4229 GLNATEGLEVVHADKDSEV--PVIEENVVPYHSTTIVGDQTTNDGHEKDKGIEKLEIGGA 4056
                +   E+V  +K+  V   +IEE        +I  +    D  + ++ +E+  +   
Sbjct: 2971 ---GSVAEEIVQEEKEGSVNEEIIEE------VGSITEEMVEQDVSDNEEIVEERSVIEE 3021

Query: 4055 DQTTATIGEEPVEDDHGETKVAETLESASAHKD----IGEHIIEE--DVPD-HSRTTISE 3897
             +    I +E  E+     +V +  +S S   +    I E I++E  DV D      +  
Sbjct: 3022 AEENVWIEKEVEEEGLDNEEVIDEEDSVSEQAEEEVYINEEILKESSDVEDVKVENELMN 3081

Query: 3896 EKVIERLEIIDANKNSGVAITDNNVVLDDSTRTTEQ------EPTKNGEEENKVIQKL-- 3741
            E+V E  + +  N      +  +N V++++   TE+        +K  +E   +I+++  
Sbjct: 3082 EEVNEETQSVAENNEEDKEL--DNYVVEETESVTEEVVVDEVPNSKEVQEIESIIEEIVE 3139

Query: 3740 EISSADKVIG------DPIIEDVPEHSTTTTGEEPV-KEGHKENKVIEQIQI---LGLDK 3591
            +  + D ++G      + ++E+V   S     E  + +E  K+  V E I +   +  D 
Sbjct: 3140 DGLTTDDLVGQQGSVIEEVVEEVGSDSEGIVEEASITEEVEKKESVTEDILVEESVTGDI 3199

Query: 3590 EIGGPVVEENVAPNH--STTVIGEE--AIHDGLEED----ETIDGLQVDSTDKVNEEAIT 3435
             + G V EE V      S  ++ EE     + +EED    E ID ++  + + V EE   
Sbjct: 3200 LVEGSVTEEVVGEEKLVSEEIVTEEGSVAQEIVEEDAPATEEIDEIESVTEEVVEEEGPV 3259

Query: 3434 KEDLAQEHSTTTTQ--------EKLIEDDHGENK--------VSTELAIGEASRD----- 3318
             E++ QE  + T +        E+++E+   EN+         S E+   E+  +     
Sbjct: 3260 DEEIVQEEGSVTEEIIQGESKVEEVVEEQGSENEEIFVEEVSASQEIVQNESGTEEILEK 3319

Query: 3317 --AVKQITKDGSITELSTVSDIKEMTKENSQEEQ-------MEAKKYEGEVKELDLSTKT 3165
              A ++I +DGS+TE   + + K +T+E   EE+        E    E  V++  ++ + 
Sbjct: 3320 VSASQEIVQDGSVTE-QIIEEQKPVTEEVVNEEESITHEIIQEESHVEKVVQQGSVAEEV 3378

Query: 3164 YEAPAS-----AQKEETMTPSDEKEQHKNQHADSATDATTGKTNEKGSEDLNDTSTGLNF 3000
             E P S      +KE ++T    +E +  +      +    +  E+ S        G + 
Sbjct: 3379 VENPVSVTEEIVEKEGSVTEDIGQEGYVAEEIVEEEEFDNEEILEEESVAEEFVEEGFDN 3438

Query: 2999 EEADMLDGSSSLIPEVYXXXXXXXXXXXXEGTEDGPNSLEGVKKASLHDAESECRELTEL 2820
            EE  +   S S I +                TE+         +  L +  S   E+ E 
Sbjct: 3439 EEIFVEQISDSEIVKEENSVNEEVLEEEGSYTEEILEEEGSYTEEILEEEGSFTEEILEE 3498

Query: 2819 SEEVNRATSIND-SENNTSKKEQGSIKNLEECIKEETIDTKLRNHLGDREIQNQEVVASV 2643
                N      + S N    +E+GS    EE ++EE   T   ++   +   N+E++   
Sbjct: 3499 EGSYNEEILEEEGSYNEEILEEEGSF--TEEILEEEGSAT---DYFVGQGSDNEEIIEEG 3553

Query: 2642 GLTSEEQNFKPVSLSEKI---ECLDAENLNKHVDDSTTTHQLQE-NHAKAGSDFIPENKV 2475
              T  +      S+ E++   E LD E + ++   +T   + +        ++ + EN +
Sbjct: 3554 SAT--DYFVGQGSIIEEVLEEEGLDTEKVFENEGSATEFEETESFTEVVEETESVNENIL 3611

Query: 2474 HEKDTYSSKKEEQNVESF-ETSKEPEIPQSWQERTIDGEKTLIEQSERESMKLERSDESD 2298
             E    +S  E Q +ES  E  KE  +P+  +E  +D E+   EQ + E +K    ++ D
Sbjct: 3612 EE----TSINEVQKIESITEDIKEQLVPEEIKEEQLDSEEIKEEQLDSEEIK---EEQLD 3664

Query: 2297 SIEVLEHTGVMDGSHEASTIKEEHSSKIIDTETVEDKKIAEDDAVHDQ-STDPCRYETVD 2121
            S E+ E   V +   E     EE   + +  E ++++++  ++   +Q  ++  + E +D
Sbjct: 3665 SEEIKEEQLVPEEIKEEQLDSEEIKEEQLVPEEIKEEQLNSEEIKEEQLDSEEIKEEQLD 3724

Query: 2120 RSLVNDE-------KEQKSIELEPELEDDYYHTRAIEQGSNSKNQNXXXXXXXXXXXXEI 1962
               + +E       KEQK    E  +E++   T  I++   S N+             E 
Sbjct: 3725 SEEIKEEQLDSEEIKEQKGSVNEEVVEEEGSVTEEIKEQEESVNEEVLEEVEETESIKEE 3784

Query: 1961 I-------QDIIVEE-HTANAAEEVIVQENSPKD--DKVSKAPEGKVKESDIVFMEASDS 1812
            I       Q+II EE  T    EE ++      D      +    +V  +D V  E S +
Sbjct: 3785 IVEGGIATQEIIEEESDTKEVVEEEVIDSEKLVDAGSVTGEVMPEEVSVTDEVVEEGSTT 3844

Query: 1811 VRXXXXXXXXXXXXEGPKKSIDNF-GTTEATLEEITKMETNDKPNYSSTESSLSEEQGMV 1635
                               +ID+F G   +T EE+ + +       S+ E  L EE    
Sbjct: 3845 EEVLEEQKSVNEEVVEDGLTIDDFVGLQGSTTEEVVEEDG------SAIEKILEEETATE 3898

Query: 1634 EIPEKTESNNNETIFATPLTERLSLQDAETEDGELVDASSLASAKMIATQNQDVDDVKQK 1455
            EI EK  S          +TE +  ++    + E+++ +S+A  ++I   +   + V Q+
Sbjct: 3899 EIVEKQVS----------VTEDIVEKEGSVNE-EIIEEASVAE-EIIQGGSFTEEIVGQE 3946

Query: 1454 KSSNLTDNRTEDKFTAENSEAAAQEKSDIPVETSSIVLQSVDRDTETASV-EEITARKPS 1278
            +S+  T+   +++    N     +EKS        +   SVD + E  SV EEI   +  
Sbjct: 3947 ESA--TEEVIDEEGLISNEIEEEEEKSVTEEMIEEVEEVSVDDEVEEVSVAEEIVEEELV 4004

Query: 1277 SVDILERNPQEPSKLVSTKEELNKIGTQVMEAPLV--EQTKREMNTQKEQ-DIKLEEDPA 1107
              +IL   P+E S      EE+  +  ++++   V  E  ++E++  +E  D K   D  
Sbjct: 4005 DDEIL---PEELSATEDVIEEVRSVTDEIVQEESVCEEILEQEVSASEEYVDDKSVTDDF 4061

Query: 1106 TGIENS-----EQKISIPE--SDTEKHISE---QKDGDVILERGDNTELNXXXXXXXXXX 957
             G E S     E   S+ E  ++ +K + E   +K G V  E  +  EL+          
Sbjct: 4062 VGHERSVIQDVENTESVTEEIAEVDKSVIEEAVEKQGSVTEEIVEEEELDTEEVLEDKSV 4121

Query: 956  XXXSLKENQPESEESSLKDHETSDTCVNIKTDILEQEEDPIKKHDQNLEEIKKEMKVDEN 777
                +++     +ES  K+  T +            E   +K+ DQ  E I +E  ++E 
Sbjct: 4122 TGDVVEQEGSGKDESEAKESFTEEV----------DELKSVKEEDQETEYISRE--IEEE 4169

Query: 776  VLEVQSTDHSNEINEPCDTTENVTIAKKNLEATDPCEELKKPTETVDHDQSQEVLPEIEK 597
                Q ++    IN+    TE++T  K   E     +E+ + T++V    ++E++ E   
Sbjct: 4170 SATEQHSEQELSINKEVVETESLT--KDIEEEKSTTQEILEETQSV----NEEIVEEERD 4223

Query: 596  TEVVNDGEIIKDQDTVFAEDRTVEQSIEEEKENDTLDKAGHKVDVEDQSNDMHHVNHLMK 417
            T+ V   ++   ++ +  +  T E+ +EE    D +      V+VED          L  
Sbjct: 4224 TDEVLKEKVSPSEEVIEEQASTTEEFLEERSSTDEI------VEVED----------LFT 4267

Query: 416  DTXXXXXXXXXXXXXEGDNIEKQSIEEEAAKCVGVLDYKTRDKEVKDSDFTSNEGIANAT 237
            +              E  +   + +EEE +    +L+  + ++E+ + + +  E I   +
Sbjct: 4268 EEVKEREGSVTEEIVEEGSDTGEIVEEEGSDAEEILEEGSFNEEIVEEEGSITEEILQGS 4327

Query: 236  YCKE--KTEPDALTCVKELNQSVNASCDTEASIEEVLEQEEVSNTASEDLG---EVVTGT 72
              +E    +   +  + E   ++    + E++ EEV E+E V+    E++    EVV G+
Sbjct: 4328 VTEEFVGQQGSVIEEIVETESAIEERVEDESATEEVDERESVTEVVEEEVSSSDEVVEGS 4387



 Score =  186 bits (471), Expect = 7e-44
 Identities = 379/1742 (21%), Positives = 722/1742 (41%), Gaps = 112/1742 (6%)
 Frame = -2

Query: 4892 TEEKSINDGREKDKITAGLAIANADKGIGEPVIEE---DVIQDQYTPTIGEEPTKECHEK 4722
            T+  S+ D   +D       I N    + E  IEE   + I      T GE  TK     
Sbjct: 1217 TDNVSVEDVNSED-------IINEHTPLEETKIEELPTEYITTADIHTRGETETKYNLIY 1269

Query: 4721 EKV---IEESKFDANKNIEEPTIEENDHSTTTILEKTIRDAHENDKAVEDAIIEDVVMDY 4551
            EK+   +E++KF   K  E   +E    +   + E ++    E  ++  + I E  + + 
Sbjct: 1270 EKINEEVEKAKFQEEKITENIPVERESVTEDIVQEPSLAQEVEQKESDTNEIEETKLAN- 1328

Query: 4550 PKKAITEETLKDGLEENKVIEGRNIVGADKDIDDPFIVED-DKCDVTATTRENSIKDGHE 4374
             +K I E ++ + + E + ++   ++  D+ I +  + E+   C+      E+S ++  E
Sbjct: 1329 -EKIIPEVSVTENVVEKEGLDTEEVLEEDESITEEIVEEEVSACEEIVEEEESSSEEIVE 1387

Query: 4373 EDKVIDEVKIVEADNDTSEHVREEEVADNSTTTIMEEPTNNDHEEDEIGLNATEGLEVVH 4194
            E++   E +IVE +  +SE + EEE  ++S+  I+EE  ++  E  E  +++TE  EV+ 
Sbjct: 1388 EEESSSE-EIVEEEESSSEEIVEEE--ESSSEEIVEEEESSSEEIIE-EVSSTE--EVLE 1441

Query: 4193 ADKDSEVPVIEENVVPYHSTTIVGDQTTNDGHEKDKGIEKLEIGGADQTTATIGEEPVED 4014
             +      ++EE V        +G  +     E+  G E+  +G       ++ EE VE 
Sbjct: 1442 EEGSVTEEIVEEEVSTTEEVKDIGSVSEEVLEEEGFGTEEF-VG----QQGSVIEEIVET 1496

Query: 4013 DHGETKVAETL-----ESASAHKDIGEHIIEEDVP--------DHSRT--------TISE 3897
            +    KV E +     E       + + I+ E+V         D S T        ++SE
Sbjct: 1497 ESSTEKVLEDVGSNVEEIVQEEGPVAQEIVHEEVSTTEKHDEVDRSTTEEIVEKVGSVSE 1556

Query: 3896 EKVIERLEIIDANKNSGVAITDNNVVLDDSTRTTEQEPTKNGEEENKVIQKLEISSADKV 3717
            E ++E +   +     G ++T+   V+++     E   T++  EE  ++QK E+S A++V
Sbjct: 1557 EIIVEEVSASEEIVEEG-SVTEE--VVEEEKLINEVGETESVTEE--IVQK-EVSDAEEV 1610

Query: 3716 IG------------DPIIEDV--PEHSTTTTGEEPVKEGHKENKVIEQIQILGLDKEIGG 3579
            +G            + I+E++  PE S T   EE V  G    +V E+  +     +  G
Sbjct: 1611 LGQEGSMNEEILEKESIVEEIVGPEGSVT---EEIVDYGSFAEEVKEEELVTEEAVQYEG 1667

Query: 3578 PVVEENVAPNHSTT---VIGEEAIHDGLEE-----DETIDGLQVDSTDKVNEEAITKEDL 3423
             V EE +    S T    I E A  + +EE     DE +    +D+ + VNE ++T E  
Sbjct: 1668 SVTEE-IKEEESITENEAIEESAFAEIIEEKGPNNDEIVKEEGLDTEEIVNEVSVTDE-- 1724

Query: 3422 AQEHSTTTTQEKLI-EDDHGENKVSTELAIGEASRDAVKQITKDG-SITELSTVSDIKEM 3249
                     +EKL+ E   GE +  TE  + E  R A + + ++G S+TE   VS  +  
Sbjct: 1725 ------VIEEEKLVNEQIVGEERSVTEKPV-EVERSATEDLVEEGASVTE--KVSVHEGS 1775

Query: 3248 TKENSQEEQMEAKKYEGEVKELDLSTKTYEAPASAQKEETMTPSDEKEQHKNQHADSATD 3069
            T E   +E +  +  E EV   D   +   +     +EE     +  E+ ++   +   +
Sbjct: 1776 TTEQILDESVAEEIVEEEVSVDDKIIEEEVSVDEVVEEEGSVIEEIVEEEESVPEEILEE 1835

Query: 3068 ATTGKTNEKGSEDLNDTSTG----LNFEEADMLDGSSSLIPEVYXXXXXXXXXXXXEGTE 2901
              +G       E + D   G    +  E  +++DG  S+  E+                E
Sbjct: 1836 ELSGSEEVLEDEWVTDAFMGQEGSVIEEIEEIVDGEGSITEEI---------------VE 1880

Query: 2900 DGPNSLEGVKKASLHDAESECRE---LTELSEEVNRATSINDSENNTSKKEQGS-IKNLE 2733
            DG  + + V++      E   +E   + E+ EE +    + D++  + K E+ S I+ ++
Sbjct: 1881 DGSANEKIVEEEPSRVEEVLGKEGFVIEEIIEEGSVIEQVEDTKTVSEKSEESSAIEEVK 1940

Query: 2732 ECIKEETIDTKLRNHLGDREIQNQEVVASVGLTSEEQNFKPVSLSEKI--ECLDAENLNK 2559
            E  +EE+I  K+        ++ +E V    +  EE      S +EKI  +    E+  +
Sbjct: 1941 EVKEEESISEKI--------VEKEESVTEEIVRQEE------STTEKIVKDVSPTEDFVE 1986

Query: 2558 HVDDSTTTHQLQENHAKAGSDFIPENKVHEKDTYSSKKEEQNVE-SFETSKEPEIPQSWQ 2382
              D  T     QE     GS+      V EK++ S + E+++V  + + + E    +S  
Sbjct: 1987 QTDSVTEKVIEQE-----GSNTEVAEDVEEKESASDEHEQEDVSVNAQVTCE---KKSVT 2038

Query: 2381 ERTIDGEKTLIEQSERESMKLERSDESDSI--EVLEHTGVMDGSHEASTIKEE--HSSKI 2214
            +  +D      E  E      E  DE+ S+  E++E   V +   E  ++ EE      +
Sbjct: 2039 KEIVDEVSRTEEIVEENGSVTEGVDETGSVTEEIIEEATVTEEVVEDGSVTEEVVEDGSV 2098

Query: 2213 IDTETVEDKKIAEDDAVHDQSTDPCRYETVDRSLVNDEKEQKSIELEPELEDDYYHTRAI 2034
            I  E VED  + E+     Q       E V+     +E+ ++ + +  E+++  Y T  +
Sbjct: 2099 IQ-EVVEDGSVTEEIV---QENGSVTEEIVEEEGSVNEEVEEEVSVSGEVDETEYVTEEV 2154

Query: 2033 -EQGS---NSKNQNXXXXXXXXXXXXEIIQDIIVE---------EHTANAAEEVIVQENS 1893
             E+GS       +              ++++I+ E         E   +  EE++ +E S
Sbjct: 2155 EEEGSVVEEIVEEEGSVVEEIVEEEGSVVEEIVEEEGSVVEEIVEEEGSVVEEIVEEEGS 2214

Query: 1892 PKDDKVSKAPEGKVKESDIVFMEAS---DSVRXXXXXXXXXXXXEGP--KKSIDNFGTT- 1731
              ++ V +  EG V E +IV  E S   + V             EG   ++ ++  G+  
Sbjct: 2215 VVEEIVEE--EGSVVE-EIVEEEGSVVEEIVEEEGSVVEEIVEEEGSVVEEIVEEEGSVV 2271

Query: 1730 -EATLEEITKMETNDKPNYSSTESSLSEEQGMVEIPEKTESNNNETIFATPLTERLSLQD 1554
             E   EE + +E   +   S  E  + EE  +VE   + E +  E I     +    + +
Sbjct: 2272 EEIVEEEGSVVEEIVEEEGSVVEEIVEEEGSVVEEIVEEEGSVVEEIVEEEGSVVEEIVE 2331

Query: 1553 AETEDGELVDASSLASAKMIATQNQDVDDVKQKKSSNLTDNRTEDKFTA---ENSEAAAQ 1383
             E    E+VD + L + + I  Q    ++V+++ S N  D   ED   A   E SE+  +
Sbjct: 2332 EEGSVSEVVDETELVNDE-IVEQAPFTEEVEEQVSVN--DEIIEDASVAEAVEESESITE 2388

Query: 1382 EKSDIPVETSSIVLQSVDRDTETASV-EEITARKPSSVDILERNPQEPSKLVSTKEELNK 1206
              S         V++ V+   ET +V EEI      + +ILE +     ++++ + +  +
Sbjct: 2389 SVSQEEETEKGFVIEKVE---ETGAVTEEIVQDGLITEEILEESESVNGEIINKESDAEE 2445

Query: 1205 IGTQVMEAPLVEQTKREMNTQKEQDIKLEEDPATGIENSE---QKISIPESDTEKHISEQ 1035
            I   +    L E+   +  +  E+ ++ E      +E  E   +++    S TE+ + E 
Sbjct: 2446 I---LETEFLTEEVVGQAGSTSEEIVEEEGSVTKEVEEKESVTEELVDEGSVTEELVDEG 2502

Query: 1034 KDGDVILERGDN------TELNXXXXXXXXXXXXXSLKENQPESEESSLKDHETSDTCVN 873
               + ++E+G +       E +              + E +  + E  ++D   ++  V 
Sbjct: 2503 SVTEEVVEQGGSIAQEIVEEESATEEIIRDETNVEEVLEKEGSATEEIVQDGSGTNDFVG 2562

Query: 872  IKTDILEQ--------EEDPIKKHDQNLEEIKKEMKVDENVLEVQSTDHSNEINEPCDTT 717
             +  ++E+         E+ +K+    +EE  +E  + E+VLE +S    N + +    T
Sbjct: 2563 KQGSVIEEVVEEEISTTEEKLKEEASAIEEFVEEESIREDVLE-ESLVTENVVGQQESVT 2621

Query: 716  ENVTIAKKNLEATDPCEELKKPTETVDHDQSQEVLPEIEKTEVVNDGEIIKDQDTVFAED 537
            E +   + +    D  EE +  TE +  D+       +E  E+V + EI++D+ +   E 
Sbjct: 2622 EEIVDGEGSF-TEDIVEEEESVTEEIVVDEESVTKEIVEDEELVTE-EIVEDEGSFTEEI 2679

Query: 536  RTVEQSIEEEK-ENDTLDKAGHKVDVEDQSNDMHHVNHLMKDTXXXXXXXXXXXXXEGDN 360
               E S  EE  E  +L +     +   +  +   +  ++ +                + 
Sbjct: 2680 VEDEGSFTEEVIEERSLIEEVEDTETVAEKEEGSVIKEIIDEKSLTEKIVEEEKSVTEEV 2739

Query: 359  IEKQSIEEEAAKCVGVLDYKTRDKEVKDSDFTSNEGIANATYCKEKTEPDALTC---VKE 189
             EK+S++EE  +   V++ +    E    D  + EGI +     E+   D L     V++
Sbjct: 2740 EEKESVKEEVEEQRLVVEEEGSATEGIVEDRLATEGIVDDILVTEEIVEDGLATDEFVEQ 2799

Query: 188  LNQSVNASCDTEASIEEVLEQEEVSNTASEDLGEVVTGTELDIPKMDNTTDTCIKGGDIE 9
                +    D E S+ E + +EE   + +E++ E V+  E D   ++  ++  ++G   E
Sbjct: 2800 QGSIIEEVLDDEGSVTEEIVEEE--GSPNEEIVEGVSVIEED-DNIEPVSEEIVEGSVTE 2856

Query: 8    RM 3
             M
Sbjct: 2857 EM 2858



 Score =  170 bits (430), Expect = 4e-39
 Identities = 366/1755 (20%), Positives = 697/1755 (39%), Gaps = 151/1755 (8%)
 Frame = -2

Query: 4889 EEKSINDGREKDKITAGLAIANADKGIGEPVIEEDVIQDQYTPTIGEEPTKECHEK---- 4722
            EE S+N+  E++   +G    +  + + E V E +++ ++     G    K   E+    
Sbjct: 519  EEGSVNEEVEEEVSVSGEV--DETEYVTEEVEETELVNEEVLKEEGSASEKVVKEEGSAS 576

Query: 4721 EKVIEESKFDANKNIEEPTIEENDHSTTTILEKTIRDAHENDKAVEDAIIEDVVMDYPKK 4542
            EK++EE      +   E  +EE    T     + I    +     E++  E++V +  + 
Sbjct: 577  EKIVEEEGSVTEETASEEIVEEEGSVTEESSSEEI--VEDEGSVTEESSSEEIVEE--EG 632

Query: 4541 AITEETLKDGLEENKVIEGRNIVGADKDIDDPFIVED----DKCDVTATTRENSIKDGHE 4374
            ++ EE+  + + E++V   + IV  +  + +  + E+    D+  VT +  +  I  G  
Sbjct: 633  SVIEESASEVIVEDEVSASKEIVEDEASVTEEVVEEEGAVSDEVQVTESVEDEIINQG-- 690

Query: 4373 EDKVIDEVKIVEADNDTSEHVREEE------VADNSTTTIMEEPTNNDHEEDEIGLNATE 4212
               ++DEV + +  + T E V+E+E        + + T ++EE    D E  + G +  E
Sbjct: 691  ---IVDEVIVEQEASVTDEIVKEDESVIEEIAVEETVTEVVEETKPMDEEIVDQG-SVVE 746

Query: 4211 GLEVVHADKDSEVPVIEENVVPYHSTTIVGDQTTNDGHEKDKGIEKLEIGGADQTTATIG 4032
             +E        E   ++E +V   S          +  E+ K +++ EIG        + 
Sbjct: 747  NVE--------EKKTMDEEIVDQGSVV--------ENVEEKKTMDE-EIGDQGSVAEKVE 789

Query: 4031 EEPVEDDHGETKVAETLESASAHKDIGEHIIEEDVPDHSRTTISEEKVIERLEIIDANKN 3852
            EE       E    E +E   +   I E I++E        +I+EE  +E++E +     
Sbjct: 790  EE-------ELVTEEVIEREGS---INEDIVKE-------ASITEE--VEQIEPVTGKVE 830

Query: 3851 SGVAITDNNVVLDDSTRTTEQEPTKNGEEENKVIQKLEISSADKVIGDPIIEDVPEHSTT 3672
               +ITD            E    +  + E  V Q+  ++  +KV    I E+V E   +
Sbjct: 831  KIESITDEI----KEQLVPEDIKEEQLDFEEIVAQRASVND-EKVEVASITEEVEEEEKS 885

Query: 3671 TTGEEPVKEGHKENKVIEQIQILGLDKEIGGPVVEENVAPNHSTT--VIGEE-AIHDGLE 3501
             + E   +EG    KV+E+     +  E  G V EE +    STT  V+ E+ ++ + L 
Sbjct: 886  VSEEVLEEEGSTTEKVVEEGSSTEVVVEEQGSVSEEVLEEEGSTTEEVVEEQGSVTENLL 945

Query: 3500 EDETIDGLQVDSTDKVNEEAITKEDLAQEHSTTTTQEKLIEDDHG---ENKVSTELAIGE 3330
            E+E+     V+  + V+EE   K+    E   + T E+L+E++ G   E+    EL I E
Sbjct: 946  EEESASQGIVEKEEFVDEEDSVKDQNVFEKEGSVT-EQLVEEEKGLINEDNEKEEL-ITE 1003

Query: 3329 ASRDAVKQITKDGSITELSTVSDIKEM---TKENSQEEQ------MEAKKYEGEVKELDL 3177
             S + +K + ++   T+LST   IK+    T E  +EE+      +E +    EV E +L
Sbjct: 1004 MSEE-IKSVNEEIEETDLSTEEIIKQQGLATYEFVEEEKSLTDKLLEEESVTKEVGETEL 1062

Query: 3176 STKTYEAPASAQKEETMTPSDEKEQHKNQHADSATD------ATTGKTNEKGSED----L 3027
            ST+       +  EE +   ++    +     SAT+      + T    EKGS+      
Sbjct: 1063 STQEVVDEKVSVTEEVI-EEEKSVSEEVLEEGSATEEVVEEGSCTEIVVEKGSDTEIVVE 1121

Query: 3026 NDTSTGLNFEEA--------------DMLDGSSSLIPEVYXXXXXXXXXXXXEGTEDGPN 2889
              ++T +  EE               +ML+   S   EV             +G  +   
Sbjct: 1122 EGSATEIVVEEGSATEVVVEEGSVSEEMLEEEGSATEEVVEEGLSSDNVQKSKGVIENVG 1181

Query: 2888 SLEGVKKASLHDAESECRELTELSEEVNRATSINDSE--NNTSKKEQGSIKNL------- 2736
             +  VK A                E +N    +  S   ++ S K QG   N+       
Sbjct: 1182 EIYSVKTAK--------------DESMNEKIPLEKSSFVDDESFKGQGPTDNVSVEDVNS 1227

Query: 2735 EECIKEET--------------IDTKLRNHLGDREIQNQEVVASVGLTSEEQNFKPVSLS 2598
            E+ I E T              I T   +  G+ E +   +   +    E+  F+   ++
Sbjct: 1228 EDIINEHTPLEETKIEELPTEYITTADIHTRGETETKYNLIYEKINEEVEKAKFQEEKIT 1287

Query: 2597 EKI---------ECLDAENLNKHVDDSTTTHQLQENHAKAGSDFIPENKVHEKDTYSSKK 2445
            E I         + +   +L + V+   +     E    A    IPE  V E     +  
Sbjct: 1288 ENIPVERESVTEDIVQEPSLAQEVEQKESDTNEIEETKLANEKIIPEVSVTE-----NVV 1342

Query: 2444 EEQNVESFETSKEPE-IPQSWQERTIDGEKTLIEQSERESMKLERSDESDSIEVLEHTGV 2268
            E++ +++ E  +E E I +   E  +   + ++E+ E  S ++   +ES S E++E    
Sbjct: 1343 EKEGLDTEEVLEEDESITEEIVEEEVSACEEIVEEEESSSEEIVEEEESSSEEIVEE--- 1399

Query: 2267 MDGSHEASTIKEEHSSKIIDTETVEDKKIAEDDAVHD-QSTDPCRYE--TVDRSLVNDE- 2100
             + S     ++EE SS     E VE+++ + ++ + +  ST+    E  +V   +V +E 
Sbjct: 1400 -EESSSEEIVEEEESS---SEEIVEEEESSSEEIIEEVSSTEEVLEEEGSVTEEIVEEEV 1455

Query: 2099 ---KEQKSI--ELEPELEDDYYHTRAI--EQGSNSKN--QNXXXXXXXXXXXXEIIQDII 1947
               +E K I    E  LE++ + T     +QGS  +   +               +++I+
Sbjct: 1456 STTEEVKDIGSVSEEVLEEEGFGTEEFVGQQGSVIEEIVETESSTEKVLEDVGSNVEEIV 1515

Query: 1946 VEEHTANAAEEVIVQE--NSPKDDKVSKAPEGKVKE-----SDIVFMEASDSVRXXXXXX 1788
             EE     A+E++ +E   + K D+V ++   ++ E     S+ + +E   +        
Sbjct: 1516 QEE--GPVAQEIVHEEVSTTEKHDEVDRSTTEEIVEKVGSVSEEIIVEEVSASEEIVEEG 1573

Query: 1787 XXXXXXEGPKKSIDNFGTTEATLEEITKMETNDKPNYSSTESSLSEEQGMVEIPEKTESN 1608
                     +K I+  G TE+  EEI + E +D       E S++E     EI EK    
Sbjct: 1574 SVTEEVVEEEKLINEVGETESVTEEIVQKEVSDAEEVLGQEGSMNE-----EILEK---- 1624

Query: 1607 NNETIFATPLTERLSLQDAETEDG---ELVDASSLASAKMIATQNQDVDDVKQKKSSNLT 1437
              E+I    +    S+ +   + G   E V    L + + +  +    +++K+++S  +T
Sbjct: 1625 --ESIVEEIVGPEGSVTEEIVDYGSFAEEVKEEELVTEEAVQYEGSVTEEIKEEES--IT 1680

Query: 1436 DNRT-EDKFTAENSEAAAQEKSDIPVETSSIVLQSVDRDTETASVEEITARKPSSVDILE 1260
            +N   E+   AE  E       +I  E      + V+  + T  V E        +   E
Sbjct: 1681 ENEAIEESAFAEIIEEKGPNNDEIVKEEGLDTEEIVNEVSVTDEVIEEEKLVNEQIVGEE 1740

Query: 1259 RNPQEPSKLV--STKEELNKIGTQVMEAPLVEQTKREMNTQKEQDIKLEEDPATGIENSE 1086
            R+  E    V  S  E+L + G  V E   V +      +  EQ +    D +   E  E
Sbjct: 1741 RSVTEKPVEVERSATEDLVEEGASVTEKVSVHE-----GSTTEQIL----DESVAEEIVE 1791

Query: 1085 QKISIPESDTEKHIS----EQKDGDVILERGDNTELNXXXXXXXXXXXXXSLKENQPESE 918
            +++S+ +   E+ +S     +++G VI E  +  E                + E +    
Sbjct: 1792 EEVSVDDKIIEEEVSVDEVVEEEGSVIEEIVEEEE-----------SVPEEILEEELSGS 1840

Query: 917  ESSLKDHETSDTCVNIKTDILEQEEDPIKKHDQNLEEIKKEMKVDENVLE---------- 768
            E  L+D   +D  +  +  ++E+ E+ +       EEI ++   +E ++E          
Sbjct: 1841 EEVLEDEWVTDAFMGQEGSVIEEIEEIVDGEGSITEEIVEDGSANEKIVEEEPSRVEEVL 1900

Query: 767  ------VQSTDHSNEINEPCDTTENVTIAKKNLEATDPCEELKKPTETVDH--DQSQEVL 612
                  ++       + E  + T+ V+   +   A +  +E+K+     +   ++ + V 
Sbjct: 1901 GKEGFVIEEIIEEGSVIEQVEDTKTVSEKSEESSAIEEVKEVKEEESISEKIVEKEESVT 1960

Query: 611  PEIEKTEVVNDGEIIKD----QDTVFAEDRTVEQSIEEEKENDTLDKAGHKVDVEDQSND 444
             EI + E     +I+KD    +D V   D   E+ IE+E  N    +    V+ ++ ++D
Sbjct: 1961 EEIVRQEESTTEKIVKDVSPTEDFVEQTDSVTEKVIEQEGSN---TEVAEDVEEKESASD 2017

Query: 443  MHH-----VNHLMKDTXXXXXXXXXXXXXEGDNIEKQS------IEEEAAKCVGVLDYKT 297
             H      VN  +                  + I +++      ++E  +    +++  T
Sbjct: 2018 EHEQEDVSVNAQVTCEKKSVTKEIVDEVSRTEEIVEENGSVTEGVDETGSVTEEIIEEAT 2077

Query: 296  RDKEVKDSDFTSNEGIANATYCKEKTEPDALT--CVKELNQSVNASCDTEASIEEVLEQE 123
              +EV +    + E + + +  +E  E  ++T   V+E         + E S+ E +E E
Sbjct: 2078 VTEEVVEDGSVTEEVVEDGSVIQEVVEDGSVTEEIVQENGSVTEEIVEEEGSVNEEVE-E 2136

Query: 122  EVSNTASEDLGEVVT 78
            EVS +   D  E VT
Sbjct: 2137 EVSVSGEVDETEYVT 2151



 Score =  165 bits (417), Expect = 1e-37
 Identities = 368/1717 (21%), Positives = 683/1717 (39%), Gaps = 147/1717 (8%)
 Frame = -2

Query: 4811 IGEPVIEEDVIQDQYTP---TIGEEPT--KECHEKEKVIEESKFDANKNIEEPTIEENDH 4647
            I E V+EE  I +  +    T+ EE T   +   +EK +EE        +EE ++ E   
Sbjct: 129  IEEIVVEELPIDEHLSSEETTVTEEDTFKGQLINEEKPVEEKSVSEEIPVEEKSVSEE-- 186

Query: 4646 STTTILEKTIRDAHENDKAVEDAIIEDVVMDYPKKAITEETLKDGLEENKVIEGRNIVGA 4467
                + EK++    E     E  + E++ ++  +K ++EE     +EE  V E   I   
Sbjct: 187  --IPVEEKSV---SEEIPVEEKNVSEEIPVE--EKNVSEEI---PVEEKNVSE--EIPVE 234

Query: 4466 DKDIDDPFIVEDDKCDVTATTRENSIKDGHEEDKVIDEVKIVEADNDTSEHVREEEVAD- 4290
            ++++ +   VE++         E ++ +   E  +  E   V+ +  T E   +E++ D 
Sbjct: 235  EENVSEEIPVEEENVSEEIPVEEENVSEEIPEGGIAIEDVPVDEETVTEEITVDEKIYDK 294

Query: 4289 --NSTTTIMEEPTNNDHEEDEIGLNATEGLEVVHADKDSEVPVIEENVVPYHSTTIVGDQ 4116
              N   T+ EE    D          TE +   H     E+ + E+       T  + D+
Sbjct: 295  LPNEIETVNEEMPVEDE-------TLTEQISSEHERVPEEI-IEEKPFTEGEETESLTDE 346

Query: 4115 TTNDGHEKDK-GIEKLEIGGADQTTATIGEEPVEDDHGETKVAETLESASAHKDIGEHII 3939
               +G   D    E++      +    +  E  E+D    KV E  ES      + E + 
Sbjct: 347  IVEEGVVTDDIPEEQIITEKVQEEEEFVTGELSEEDIINEKVQEEDES------VTEELP 400

Query: 3938 EEDVPDHSRTTISEEKVIERLEII-DANKNSGVAITD--NNVVLDDSTRTTEQEPTKNG- 3771
            EED+ +     + EE+     EI+ D +    V   +  N+ V D      E++P K   
Sbjct: 401  EEDIINEK---VQEEEESAYQEIVQDGSVTKDVEYKELVNDDVRDKENFVIEEDPFKGQL 457

Query: 3770 EEENKVIQKLEISSADKVIGDPIIEDVPEHSTTTTGEEPVKEGHKENKVIEQIQILGLDK 3591
              E   +++  ++    V  + + E++ E   + T E PV+E H   K +++I+      
Sbjct: 458  INEGLPVEEEFVTKELPVKEESVFEELTEEDQSVTKEIPVEE-HSVFKEVDEIE------ 510

Query: 3590 EIGGPVVEENVAPNHSTTVIGEEAIHDGLEEDET-IDGLQVDSTDKVNEEAITKEDLAQE 3414
                 V EE V    S     EE +    E DET     +V+ T+ VNEE + +E  A E
Sbjct: 511  ----SVTEEIVEEEGSVNEEVEEEVSVSGEVDETEYVTEEVEETELVNEEVLKEEGSASE 566

Query: 3413 ---HSTTTTQEKLIEDDHGENKVSTELAIGEASRDAVKQITKDGSITELSTVSDIKE--- 3252
                   +  EK++E+   E  V+ E A  E        + ++GS+TE S+  +I E   
Sbjct: 567  KVVKEEGSASEKIVEE---EGSVTEETASEEI-------VEEEGSVTEESSSEEIVEDEG 616

Query: 3251 -MTKENSQEEQMEAKKYEGEVKELDLSTKTYEAPASAQKEETMTPSDEKEQHKNQHADSA 3075
             +T+E+S EE +E    EG V E   S    E   SA KE     +   E+   +    +
Sbjct: 617  SVTEESSSEEIVEE---EGSVIEESASEVIVEDEVSASKEIVEDEASVTEEVVEEEGAVS 673

Query: 3074 TDATTGKTNEKGSEDLNDTSTGLNFEEADMLDGSSSLIPEVYXXXXXXXXXXXXEGT--- 2904
             +          +E + D        +  +++  +S+  E+             E T   
Sbjct: 674  DEVQV-------TESVEDEIINQGIVDEVIVEQEASVTDEIVKEDESVIEEIAVEETVTE 726

Query: 2903 ---EDGPNSLEGVKKASLHDAESECRELTELSEEVNRATSI-NDSENNTSKKEQGSIKNL 2736
               E  P   E V + S+ +   E + + E  E V++ + + N  E  T  +E G   ++
Sbjct: 727  VVEETKPMDEEIVDQGSVVENVEEKKTMDE--EIVDQGSVVENVEEKKTMDEEIGDQGSV 784

Query: 2735 EECIKEETIDTKLRNHLGDREIQ-NQEVVASVGLTSEEQNFKPVS-LSEKIECLDAENLN 2562
             E ++EE + T+    + +RE   N+++V    +T E +  +PV+   EKIE +  E   
Sbjct: 785  AEKVEEEELVTE---EVIEREGSINEDIVKEASITEEVEQIEPVTGKVEKIESITDEIKE 841

Query: 2561 KHVDDSTTTHQLQENHAKAGSDFIPENKVHEKDTYSSKKEEQNVESFETSKEPEIPQSWQ 2382
            + V +     QL      A    + + KV         +EE+   S E  +E     S  
Sbjct: 842  QLVPEDIKEEQLDFEEIVAQRASVNDEKVEVASITEEVEEEEKSVSEEVLEE---EGSTT 898

Query: 2381 ERTI-DGEKTLIEQSERESMKLERSDESDSI--EVLEHTGVMDGSHEASTIKEEHSSK-I 2214
            E+ + +G  T +   E+ S+  E  +E  S   EV+E      GS   + ++EE +S+ I
Sbjct: 899  EKVVEEGSSTEVVVEEQGSVSEEVLEEEGSTTEEVVEE----QGSVTENLLEEESASQGI 954

Query: 2213 IDTETVEDKKIAEDDAVHDQS--------TDPCRYETVDRSLVNDEKEQKSI-------- 2082
            ++ E   D    E+D+V DQ+        T+    E  ++ L+N++ E++ +        
Sbjct: 955  VEKEEFVD----EEDSVKDQNVFEKEGSVTEQLVEE--EKGLINEDNEKEELITEMSEEI 1008

Query: 2081 -ELEPELEDDYYHTRAI--------------EQGSNSKNQNXXXXXXXXXXXXEIIQDII 1947
              +  E+E+    T  I              E+    K                  Q+++
Sbjct: 1009 KSVNEEIEETDLSTEEIIKQQGLATYEFVEEEKSLTDKLLEEESVTKEVGETELSTQEVV 1068

Query: 1946 VEEHTANAAEEVIVQENSPKDDKVSK--APEGKVKE---SDIVFMEASDSVRXXXXXXXX 1782
             E+   +  EEVI +E S  ++ + +  A E  V+E   ++IV  + SD+          
Sbjct: 1069 DEK--VSVTEEVIEEEKSVSEEVLEEGSATEEVVEEGSCTEIVVEKGSDT-------EIV 1119

Query: 1781 XXXXEGPKKSIDNFGTTEATLEEITKMETNDKPNYSSTESSLSE---------EQGMVE- 1632
                   +  ++    TE  +EE +  E   +   S+TE  + E          +G++E 
Sbjct: 1120 VEEGSATEIVVEEGSATEVVVEEGSVSEEMLEEEGSATEEVVEEGLSSDNVQKSKGVIEN 1179

Query: 1631 ------------------IP-EKTESNNNETIFATPLTERLSLQDAETEDGELVDASSLA 1509
                              IP EK+   ++E+      T+ +S++D  +ED  + + + L 
Sbjct: 1180 VGEIYSVKTAKDESMNEKIPLEKSSFVDDESFKGQGPTDNVSVEDVNSED-IINEHTPLE 1238

Query: 1508 SAKM--IATQNQDVDDVKQKKSSNLTDNRTEDKFTAENSEAAAQEK---SDIPVETSSIV 1344
              K+  + T+     D+  +  +    N   +K   E  +A  QE+    +IPVE     
Sbjct: 1239 ETKIEELPTEYITTADIHTRGETETKYNLIYEKINEEVEKAKFQEEKITENIPVERE--- 1295

Query: 1343 LQSVDRDTETASVEEITARKPSSVDILERNPQEPSKLVSTKEELNKIGTQVMEAPLVEQT 1164
                       SV E   ++PS    +E+   + +++  TK    KI   + E  + E  
Sbjct: 1296 -----------SVTEDIVQEPSLAQEVEQKESDTNEIEETKLANEKI---IPEVSVTENV 1341

Query: 1163 KREMNTQKEQDIKLEEDPATGIENSEQKISIPESDTEKHISEQKDGDVILERGDNTELNX 984
              +     E+   LEED +   E  E+++S  E   E+   E+   + I+E  +++  + 
Sbjct: 1342 VEKEGLDTEE--VLEEDESITEEIVEEEVSACEEIVEE---EESSSEEIVEEEESS--SE 1394

Query: 983  XXXXXXXXXXXXSLKENQPESEESSLKDHETSDTC---VNIKTDILEQE----EDPIKKH 825
                         ++E +  SEE   ++  +S+     V+   ++LE+E    E+ +++ 
Sbjct: 1395 EIVEEEESSSEEIVEEEESSSEEIVEEEESSSEEIIEEVSSTEEVLEEEGSVTEEIVEEE 1454

Query: 824  DQNLEEIKKEMKVDENVLEVQSTDHSNEINEPCDTTENVTIAKKNLEAT-----DPCEEL 660
                EE+K    V E VLE +       + +     E +   + + E          EE+
Sbjct: 1455 VSTTEEVKDIGSVSEEVLEEEGFGTEEFVGQQGSVIEEIVETESSTEKVLEDVGSNVEEI 1514

Query: 659  -------------KKPTETVDHDQSQEVLPE--IEKTEVVNDGEIIKD---QDTVFAEDR 534
                         ++ + T  HD+      E  +EK   V++  I+++    + +  E  
Sbjct: 1515 VQEEGPVAQEIVHEEVSTTEKHDEVDRSTTEEIVEKVGSVSEEIIVEEVSASEEIVEEGS 1574

Query: 533  TVEQSIEEEKENDTLDKAGHKVDVEDQSNDMHHVNHLMKDTXXXXXXXXXXXXXEGDNIE 354
              E+ +EEEK    +++ G    V ++         + K+                + +E
Sbjct: 1575 VTEEVVEEEK---LINEVGETESVTEEI--------VQKEVSDAEEVLGQEGSMNEEILE 1623

Query: 353  KQSIEEEAAKCVG-----VLDYKTRDKEVKDSDFTSNEGIA-NATYCKEKTEPDALTCVK 192
            K+SI EE     G     ++DY +  +EVK+ +  + E +    +  +E  E +++T  +
Sbjct: 1624 KESIVEEIVGPEGSVTEEIVDYGSFAEEVKEEELVTEEAVQYEGSVTEEIKEEESITENE 1683

Query: 191  ELNQSVNASC-------DTEASIEEVLEQEEVSNTAS 102
             + +S  A         + E   EE L+ EE+ N  S
Sbjct: 1684 AIEESAFAEIIEEKGPNNDEIVKEEGLDTEEIVNEVS 1720



 Score =  164 bits (416), Expect = 2e-37
 Identities = 375/1840 (20%), Positives = 738/1840 (40%), Gaps = 218/1840 (11%)
 Frame = -2

Query: 4889 EEKSINDGREKDKITAGLAIANADKGIGE--PVIEEDVIQDQYTPTIGEEPTKECHEKEK 4716
            EEK++++    ++      I   +K + E  PV EE+V ++   P   E  ++E   +E+
Sbjct: 201  EEKNVSEEIPVEEKNVSEEIPVEEKNVSEEIPVEEENVSEE--IPVEEENVSEEIPVEEE 258

Query: 4715 VIEESKFDANKNIEEPTIEENDHSTTTILEKTIRDA--HENDKAVEDAIIEDVVMDYPKK 4542
             + E   +    IE+  ++E   +    +++ I D   +E +   E+  +ED  +     
Sbjct: 259  NVSEEIPEGGIAIEDVPVDEETVTEEITVDEKIYDKLPNEIETVNEEMPVEDETLTEQIS 318

Query: 4541 AITEETLKDGLEENKVIEGRNIVGADKDIDDPFIVEDDKCDVTATT-----RENSIKDGH 4377
            +  E   ++ +EE    EG        +I +  +V DD  +    T      E  +    
Sbjct: 319  SEHERVPEEIIEEKPFTEGEETESLTDEIVEEGVVTDDIPEEQIITEKVQEEEEFVTGEL 378

Query: 4376 EEDKVIDEVKIVEADNDTSEHVREEE-----------------VADNSTTTIME--EPTN 4254
             E+ +I+E K+ E D   +E + EE+                 V D S T  +E  E  N
Sbjct: 379  SEEDIINE-KVQEEDESVTEELPEEDIINEKVQEEEESAYQEIVQDGSVTKDVEYKELVN 437

Query: 4253 ND--------HEEDEI-GLNATEGLEVVHADKDSEVPVIEENV----------------V 4149
            +D         EED   G    EGL V       E+PV EE+V                V
Sbjct: 438  DDVRDKENFVIEEDPFKGQLINEGLPVEEEFVTKELPVKEESVFEELTEEDQSVTKEIPV 497

Query: 4148 PYHST--------TIVGDQTTNDGHEKDKGIEKLEIGGADQTTATIGEEPVEDDHGETKV 3993
              HS         ++  +    +G   ++  E++ + G    T  + EE  E +    +V
Sbjct: 498  EEHSVFKEVDEIESVTEEIVEEEGSVNEEVEEEVSVSGEVDETEYVTEEVEETELVNEEV 557

Query: 3992 AETLESASAH--KDIG---EHIIEEDVPDHSRTTISEEKVIERLEIIDANKNSGVAITDN 3828
             +   SAS    K+ G   E I+EE+    +  T SEE V E   + + + +  +   + 
Sbjct: 558  LKEEGSASEKVVKEEGSASEKIVEEE-GSVTEETASEEIVEEEGSVTEESSSEEIVEDEG 616

Query: 3827 NVVLDDST-RTTEQEPTKNGEEENKVIQKLEISSADKVIGD--PIIEDVPEHSTTTTGEE 3657
            +V  + S+    E+E +   E  ++VI + E+S++ +++ D   + E+V E     + E 
Sbjct: 617  SVTEESSSEEIVEEEGSVIEESASEVIVEDEVSASKEIVEDEASVTEEVVEEEGAVSDEV 676

Query: 3656 PVKEGHKENKVIEQIQILGLDKEIGGPVVEENVAPNHST--TVIGEEAIHDGLEEDETID 3483
             V E   E+++I Q  +  +  E    V +E V  + S    +  EE + + +EE + +D
Sbjct: 677  QVTES-VEDEIINQGIVDEVIVEQEASVTDEIVKEDESVIEEIAVEETVTEVVEETKPMD 735

Query: 3482 GLQVDS---TDKVNEEAITKEDLAQEHST--TTTQEKLIEDDHG----------ENKVST 3348
               VD     + V E+    E++  + S      ++K ++++ G          E ++ T
Sbjct: 736  EEIVDQGSVVENVEEKKTMDEEIVDQGSVVENVEEKKTMDEEIGDQGSVAEKVEEEELVT 795

Query: 3347 ELAIGEASRDAVKQITKDGSITELSTVSDIKEMT----KENSQEEQMEAKKYEGEVKELD 3180
            E  I E      + I K+ SITE   V  I+ +T    K  S  ++++ +    ++KE  
Sbjct: 796  EEVI-EREGSINEDIVKEASITE--EVEQIEPVTGKVEKIESITDEIKEQLVPEDIKEEQ 852

Query: 3179 LSTK---TYEAPASAQKEETMTPSDEKEQHKNQHADSATDATTGKTNEKGSEDLNDTSTG 3009
            L  +      A  + +K E  + ++E E+ +   ++   +   G T EK  E+ + T   
Sbjct: 853  LDFEEIVAQRASVNDEKVEVASITEEVEEEEKSVSEEVLE-EEGSTTEKVVEEGSSTEVV 911

Query: 3008 LNFE---EADMLDGSSSLIPEVYXXXXXXXXXXXXEGT--------EDGPNSLEGVKKAS 2862
            +  +     ++L+   S   EV             E +        E+  +  + VK  +
Sbjct: 912  VEEQGSVSEEVLEEEGSTTEEVVEEQGSVTENLLEEESASQGIVEKEEFVDEEDSVKDQN 971

Query: 2861 LHDAESECRE-------------------LTELSEEVNRAT-SINDSENNTSK--KEQG- 2751
            + + E    E                   +TE+SEE+      I +++ +T +  K+QG 
Sbjct: 972  VFEKEGSVTEQLVEEEKGLINEDNEKEELITEMSEEIKSVNEEIEETDLSTEEIIKQQGL 1031

Query: 2750 -------SIKNLEECIKEETIDTKLRNHLGDREIQNQEVVASVGLTSEEQNFKPVSLSEK 2592
                     K+L + + EE   TK    +G+ E+  QEVV      +EE   +  S+SE+
Sbjct: 1032 ATYEFVEEEKSLTDKLLEEESVTK---EVGETELSTQEVVDEKVSVTEEVIEEEKSVSEE 1088

Query: 2591 I--------ECLDAENLNKHVDDSTTTHQLQENHAKAGSDFIPENKVHEKDTYSSKKEEQ 2436
            +        E ++  +  + V +  +  ++      A    + E    E         E+
Sbjct: 1089 VLEEGSATEEVVEEGSCTEIVVEKGSDTEIVVEEGSATEIVVEEGSATEVVVEEGSVSEE 1148

Query: 2435 NVESFETSKEPEIPQSWQERTIDGEKTLIEQ-SERESMKLERSDESDSIEVLEHTGVMD- 2262
             +E   ++ E  + +      +   K +IE   E  S+K  + +  +    LE +  +D 
Sbjct: 1149 MLEEEGSATEEVVEEGLSSDNVQKSKGVIENVGEIYSVKTAKDESMNEKIPLEKSSFVDD 1208

Query: 2261 ------GSHEASTIKEEHSSKIIDTET-VEDKKIAE-------DDAVHDQSTDPCRY--- 2133
                  G  +  ++++ +S  II+  T +E+ KI E          +H +     +Y   
Sbjct: 1209 ESFKGQGPTDNVSVEDVNSEDIINEHTPLEETKIEELPTEYITTADIHTRGETETKYNLI 1268

Query: 2132 -----ETVDRSLVNDEKEQKSIELEPE-LEDDYYHTRAIEQGSNSKNQNXXXXXXXXXXX 1971
                 E V+++   +EK  ++I +E E + +D     ++ Q    K  +           
Sbjct: 1269 YEKINEEVEKAKFQEEKITENIPVERESVTEDIVQEPSLAQEVEQKESDTNEIEETKLAN 1328

Query: 1970 XEIIQDIIVEEHTANA----AEEVIVQENSPKDDKVSK---APEGKVKESDIVFMEASDS 1812
             +II ++ V E+         EEV+ ++ S  ++ V +   A E  V+E +     +S+ 
Sbjct: 1329 EKIIPEVSVTENVVEKEGLDTEEVLEEDESITEEIVEEEVSACEEIVEEEE----SSSEE 1384

Query: 1811 VRXXXXXXXXXXXXEGPKKSIDNFGTTEATLEEITKMETNDKPNYSSTESSLSEEQGMVE 1632
            +             E    S +     E++ EEI + E       SS+E  + E     E
Sbjct: 1385 IVEEEESSSEEIVEEEESSSEEIVEEEESSSEEIVEEEE------SSSEEIIEEVSSTEE 1438

Query: 1631 IPEKTESNNNETIFATPLTERLSLQDAETEDGELVDASSLASAKMIATQNQDVDDVKQKK 1452
            + E+ E +  E I    ++    ++D  +   E+++     + + +  Q   ++++ + +
Sbjct: 1439 VLEE-EGSVTEEIVEEEVSTTEEVKDIGSVSEEVLEEEGFGTEEFVGQQGSVIEEIVETE 1497

Query: 1451 SSNLTDNRTEDKFTAENSEAAAQEKSDIPVE------TSSIVLQSVDRDTETASV----- 1305
            SS  T+   ED     N E   QE+  +  E      +++     VDR T    V     
Sbjct: 1498 SS--TEKVLED--VGSNVEEIVQEEGPVAQEIVHEEVSTTEKHDEVDRSTTEEIVEKVGS 1553

Query: 1304 --EEITARKPSSVDILERNPQEPSKLVSTKEELNKIG-TQVMEAPLVEQTKREMNTQKEQ 1134
              EEI   + S+ + +        ++V  ++ +N++G T+ +   +V++   +      Q
Sbjct: 1554 VSEEIIVEEVSASEEIVEEGSVTEEVVEEEKLINEVGETESVTEEIVQKEVSDAEEVLGQ 1613

Query: 1133 DIKLEEDPATGIENSEQKISIPESDTEKHISEQKDGDVILERGDNTELNXXXXXXXXXXX 954
            +  + E+     E+  ++I  PE    + I    D     E     EL            
Sbjct: 1614 EGSMNEE-ILEKESIVEEIVGPEGSVTEEI---VDYGSFAEEVKEEELVTEEAVQYEGSV 1669

Query: 953  XXSLKENQPESEESSLKDHETSDTCVNIKTDILEQE----EDPIKKHDQNLEEIKKEMKV 786
               +KE +  +E  ++++        +   +I+E++    ++ +K+   + EEI  E+ V
Sbjct: 1670 TEEIKEEESITENEAIEE--------SAFAEIIEEKGPNNDEIVKEEGLDTEEIVNEVSV 1721

Query: 785  DENVLEVQSTDHSNEINEPCDTTENVTIAKKNLEATDPCEELKKPTETVD-HDQS----- 624
             + V+E +   +   + E    TE     +++    D  EE    TE V  H+ S     
Sbjct: 1722 TDEVIEEEKLVNEQIVGEERSVTEKPVEVERS-ATEDLVEEGASVTEKVSVHEGSTTEQI 1780

Query: 623  --QEVLPEIEKTEVVNDGEIIKDQ---DTVFAEDRTVEQSIEEEKENDTLDKAGHKVDVE 459
              + V  EI + EV  D +II+++   D V  E+ +V + I EE+E+   +    ++   
Sbjct: 1781 LDESVAEEIVEEEVSVDDKIIEEEVSVDEVVEEEGSVIEEIVEEEESVPEEILEEELSGS 1840

Query: 458  DQSNDMHHVNHLMKDTXXXXXXXXXXXXXEGDNIEKQSIEEEAAKCVGVLDYKTRDKEVK 279
            ++  +   V                       +I ++ +E+ +A    V +  +R +EV 
Sbjct: 1841 EEVLEDEWVTDAFMGQEGSVIEEIEEIVDGEGSITEEIVEDGSANEKIVEEEPSRVEEVL 1900

Query: 278  DSD-FTSNEGIANA----------TYCKEKTEPDALTCVKELNQSVNAS---CDTEASI- 144
              + F   E I             T  ++  E  A+  VKE+ +  + S    + E S+ 
Sbjct: 1901 GKEGFVIEEIIEEGSVIEQVEDTKTVSEKSEESSAIEEVKEVKEEESISEKIVEKEESVT 1960

Query: 143  EEVLEQEEVSNTASEDLGEVVTGTELDIPKMDNTTDTCIK 24
            EE++ QEE   + +E + + V+ TE  + + D+ T+  I+
Sbjct: 1961 EEIVRQEE---STTEKIVKDVSPTEDFVEQTDSVTEKVIE 1997



 Score =  153 bits (387), Expect = 4e-34
 Identities = 325/1688 (19%), Positives = 705/1688 (41%), Gaps = 125/1688 (7%)
 Frame = -2

Query: 4805 EPVIEEDVIQDQYTPTIGEEPTKECHEKEKVIEESKFDANKNIEEPT-----IEENDHST 4641
            E  ++E+++Q++ + T  EE  +   + E+V+EE   +  +   E       I +N+  T
Sbjct: 3256 EGPVDEEIVQEEGSVT--EEIIQGESKVEEVVEEQGSENEEIFVEEVSASQEIVQNESGT 3313

Query: 4640 TTILEKT------IRDAHENDKAVEDA--IIEDVVMDYPKKAITEETLKDGLEENKVIEG 4485
              ILEK       ++D    ++ +E+   + E+VV +  +++IT E +++     KV++ 
Sbjct: 3314 EEILEKVSASQEIVQDGSVTEQIIEEQKPVTEEVVNE--EESITHEIIQEESHVEKVVQQ 3371

Query: 4484 RNIVGADKDIDDPFIVEDDKCDVTATTRENSIKDGHEEDKVIDEVKIVEADNDTSEHVRE 4305
             ++  A++ +++P  V ++  +   +  E+  ++G+  +++++E +      D  E + E
Sbjct: 3372 GSV--AEEVVENPVSVTEEIVEKEGSVTEDIGQEGYVAEEIVEEEEF-----DNEEILEE 3424

Query: 4304 EEVADNSTTTIMEEPTNNDHEEDEIGLNATEGLEVVHADKDSEVPVIEENVVPYHSTTIV 4125
            E VA        EE      + +EI +      E+V  +      V+EE    Y    + 
Sbjct: 3425 ESVA--------EEFVEEGFDNEEIFVEQISDSEIVKEENSVNEEVLEEEG-SYTEEILE 3475

Query: 4124 GDQTTNDGHEKDKGI---EKLEIGGAD-----QTTATIGEEPVEDDHGETKVAETLESAS 3969
             + +  +   +++G    E LE  G+      +   +  EE +E++   T+     E ++
Sbjct: 3476 EEGSYTEEILEEEGSFTEEILEEEGSYNEEILEEEGSYNEEILEEEGSFTEEILEEEGSA 3535

Query: 3968 AHKDIGEHIIEEDVPDHSRTT---ISEEKVIERLEIIDANKNSGVAITDNNVVLDDSTRT 3798
                +G+    E++ +    T   + +  +IE  E+++          D   V ++    
Sbjct: 3536 TDYFVGQGSDNEEIIEEGSATDYFVGQGSIIE--EVLEEEG------LDTEKVFENEGSA 3587

Query: 3797 TEQEPTKNGEE--------ENKVIQKLEISSADKVIGDPIIEDVPEHSTTTTGEEPVKEG 3642
            TE E T++  E           ++++  I+   K+  + I ED+ E        E +KE 
Sbjct: 3588 TEFEETESFTEVVEETESVNENILEETSINEVQKI--ESITEDIKEQLVP----EEIKEE 3641

Query: 3641 HKENKVIEQIQILGLDKEIGGPVVEENVAPNHSTTVIGEEAIHDGLEEDETIDGLQVDST 3462
              +++ I++ Q   LD E    + EE +    S  +  E+ + + ++E+      Q+DS 
Sbjct: 3642 QLDSEEIKEEQ---LDSE---EIKEEQL---DSEEIKEEQLVPEEIKEE------QLDS- 3685

Query: 3461 DKVNEEAITKEDLAQE--HSTTTTQEKLIEDDHGENKVSTELAIGEASRDAVKQITKDGS 3288
            +++ EE +  E++ +E  +S    +E+L  ++  E ++ +E  I E   D+ +   + GS
Sbjct: 3686 EEIKEEQLVPEEIKEEQLNSEEIKEEQLDSEEIKEEQLDSE-EIKEEQLDSEEIKEQKGS 3744

Query: 3287 ITELSTVSDIKEMTKENSQEEQMEAKKYEGEVKELDLSTKTYEAPASAQKEETMTPSDEK 3108
            + E   V +   +T+E  ++E+   ++   EV+E +   +       A +E     SD K
Sbjct: 3745 VNE-EVVEEEGSVTEEIKEQEESVNEEVLEEVEETESIKEEIVEGGIATQEIIEEESDTK 3803

Query: 3107 EQHKNQHADSATDATTGK-TNEKGSEDLNDTST----GLNFEEADMLDGSSSLIPEVYXX 2943
            E  + +  DS      G  T E   E+++ T      G   EE  +L+   S+  EV   
Sbjct: 3804 EVVEEEVIDSEKLVDAGSVTGEVMPEEVSVTDEVVEEGSTTEE--VLEEQKSVNEEVVED 3861

Query: 2942 XXXXXXXXXXEGT-------EDGPNSLEGVKKASLHDAESECRELTELSEEVNRATSIND 2784
                      +G+       EDG +++E + +      E   ++++   + V +  S+N+
Sbjct: 3862 GLTIDDFVGLQGSTTEEVVEEDG-SAIEKILEEETATEEIVEKQVSVTEDIVEKEGSVNE 3920

Query: 2783 S--ENNTSKKE--QGS-----IKNLEECIKEETIDTK--LRNHLGDREIQN--QEVVASV 2643
               E  +  +E  QG      I   EE   EE ID +  + N + + E ++  +E++  V
Sbjct: 3921 EIIEEASVAEEIIQGGSFTEEIVGQEESATEEVIDEEGLISNEIEEEEEKSVTEEMIEEV 3980

Query: 2642 GLTSEEQNFKPVSLSEKI---ECLDAENLNKH------------------VDDSTTTHQL 2526
               S +   + VS++E+I   E +D E L +                   V + +   ++
Sbjct: 3981 EEVSVDDEVEEVSVAEEIVEEELVDDEILPEELSATEDVIEEVRSVTDEIVQEESVCEEI 4040

Query: 2525 QENHAKAGSDFIPENKVHEKDTYSSKKEEQNVESFETSKEP--EIPQSWQERTIDGEKTL 2352
             E    A  +++ +  V +      +   Q+VE+ E+  E   E+ +S  E  ++ + ++
Sbjct: 4041 LEQEVSASEEYVDDKSVTDDFVGHERSVIQDVENTESVTEEIAEVDKSVIEEAVEKQGSV 4100

Query: 2351 IEQSERESMKLERSDESDSIEVLEHTGVM-DGSHEASTIKEEHSSKIIDTETVEDKKIAE 2175
             E+   E       +E D+ EVLE   V  D   +  + K+E  +K   TE V++ K  +
Sbjct: 4101 TEEIVEE-------EELDTEEVLEDKSVTGDVVEQEGSGKDESEAKESFTEEVDELKSVK 4153

Query: 2174 DDAVHDQSTDPCRYETVDRSLVNDEKEQKSIELEPELEDDYYHTRAIEQGSNSKNQNXXX 1995
            ++   DQ T+    E  + S      EQ+ + +  E+ +    T+ IE+  ++  +    
Sbjct: 4154 EE---DQETEYISREIEEESATEQHSEQE-LSINKEVVETESLTKDIEEEKSTTQE---- 4205

Query: 1994 XXXXXXXXXEIIQDIIVEEHTANAAEEVIVQENSPKDDKVSKAP-------EGKVKESDI 1836
                      + ++I+ EE      +EV+ ++ SP ++ + +         E +    +I
Sbjct: 4206 ---ILEETQSVNEEIVEEERDT---DEVLKEKVSPSEEVIEEQASTTEEFLEERSSTDEI 4259

Query: 1835 VFMEA--SDSVRXXXXXXXXXXXXEGPKKS--IDNFGTTEATL-------EEITKME--- 1698
            V +E   ++ V+            EG      ++  G+    +       EEI + E   
Sbjct: 4260 VEVEDLFTEEVKEREGSVTEEIVEEGSDTGEIVEEEGSDAEEILEEGSFNEEIVEEEGSI 4319

Query: 1697 TNDKPNYSSTESSLSEEQGMVEIPEKTESNNNETIFATPLTERLSLQDAETEDGELVDAS 1518
            T +    S TE  + ++  ++E   +TES   E +     TE +  +++ TE   +V+  
Sbjct: 4320 TEEILQGSVTEEFVGQQGSVIEEIVETESAIEERVEDESATEEVDERESVTE---VVEEE 4376

Query: 1517 SLASAKMIATQNQDVDDVKQKKSSNLTDNRTEDKFTAENSEAAAQEKSDIPVETSSIVLQ 1338
              +S +++    ++V +       ++T+   E + +A+ +           VE +  V +
Sbjct: 4377 VSSSDEVVEGSIEEVIE----NEGSVTEEILEHEVSADENFVGQAVSVIEEVEGTESVTE 4432

Query: 1337 SVDRDTETASVEEITARKPSSV-----DILERNPQEPSKLVSTKEELNKIGTQVMEAPLV 1173
             V  +TE+ S E +      +V      ++E + ++     + + ++ ++G   +E    
Sbjct: 4433 EVVEETESVSEEIVEVSPTENVVQQTDSVIEEDVEQKEGSFNEEIDIRELGDDGVEEREK 4492

Query: 1172 EQTKREMNTQKEQDIKLEEDPATG----IENSEQKISIPESDTEKHISEQKDGDVILERG 1005
              T+  +   K     +EE  +TG    + ++E +  +  ++  + +S  +  + +    
Sbjct: 4493 ISTEEVVGQDKSATGDVEESSSTGDVEEVSSTEDEEEVSSTEGLEEVSSTEGLEEVSNTE 4552

Query: 1004 DNTELNXXXXXXXXXXXXXSLKENQPESEESSLKDHETSDTCVNIKTDILEQEEDPIKKH 825
            D  E++              +KE +  +EE S+++        +I TD +  E++ + + 
Sbjct: 4553 DVEEVSSTEDVEEGSVAEN-VKETKSITEEVSVEE--------DIITDKVSVEQEVMAEA 4603

Query: 824  DQNLEEIKKEMKVDENVLEVQSTDHSNEINEPCDTTENVTIAKKNLEATDPCE------- 666
                E I  E+ V+E ++  + +     +NE   + E + I   N+    P E       
Sbjct: 4604 SVE-ENILTEVPVEEEIMTEKLSVEDKALNEKIMSEEEIVIEDGNVHEVVPAEVSVTEEI 4662

Query: 665  -ELKKPTETVDHDQSQEVLPEIEKTEVVNDGEIIKDQDTVFAEDRTVEQSIEEEKENDTL 489
              +++ T    H + + V+ E+    VV+D  +  + +  F +D ++E    + K+    
Sbjct: 4663 PGVEETTNNESHVKGENVVNEV----VVDDNSV--NDEIQFDDDSSIEIYTVDSKDVFHK 4716

Query: 488  DKAGHKVDVEDQSNDMHHVNHLMKD--TXXXXXXXXXXXXXEGDNIEKQSIEEEAAKCVG 315
            ++       E +S++  H++    +                  +   K++I EE    + 
Sbjct: 4717 EENYDSFREEVRSDENIHISRKKNENFVKKIENEKSSVGHVPTEYTSKENIAEEVPSHIM 4776

Query: 314  VLDYKTRD--KEVKDSDFTSNEGIANATYCKEKTEPDALTCVKELNQSVNASCDTEASIE 141
              +  T +  KEVK  + T  E     T  KE         ++E    +N+  +    + 
Sbjct: 4777 FKENVTEEVPKEVKYEENTVEEVFEEVT-SKE-------NIIEEAPGDINSEENIIEEVP 4828

Query: 140  EVLEQEEV 117
            EV+  EE+
Sbjct: 4829 EVVTSEEI 4836



 Score =  151 bits (381), Expect = 2e-33
 Identities = 312/1516 (20%), Positives = 602/1516 (39%), Gaps = 122/1516 (8%)
 Frame = -2

Query: 4886 EKSINDGREKDKI----TAGLAIANADKGIGEPVIEED------VIQDQ--YTPTIGEEP 4743
            E+ + +G + ++I     +   I   +  + E V+EE+      +++++  YT  I EE 
Sbjct: 3429 EEFVEEGFDNEEIFVEQISDSEIVKEENSVNEEVLEEEGSYTEEILEEEGSYTEEILEEE 3488

Query: 4742 ---TKECHEKEKVIEESKFDANKNIEEPTIEENDHSTTTILEKT-------IRDAHENDK 4593
               T+E  E+E    E   +   +  E  +EE    T  ILE+        +    +N++
Sbjct: 3489 GSFTEEILEEEGSYNEEILEEEGSYNEEILEEEGSFTEEILEEEGSATDYFVGQGSDNEE 3548

Query: 4592 AVEDAIIEDVVMDYPKKAITEETLKD-GLEENKVIEGRNIVGADKDIDD-PFIVED---- 4431
             +E+    D  +   + +I EE L++ GL+  KV E        ++ +    +VE+    
Sbjct: 3549 IIEEGSATDYFVG--QGSIIEEVLEEEGLDTEKVFENEGSATEFEETESFTEVVEETESV 3606

Query: 4430 -----DKCDVTATTRENSIKDGHEEDKVIDEVKIVEADNDTSEHVREEEVADNSTTTIME 4266
                 ++  +    +  SI +  +E  V +E+K  + D   SE ++EE++         E
Sbjct: 3607 NENILEETSINEVQKIESITEDIKEQLVPEEIKEEQLD---SEEIKEEQLDS-------E 3656

Query: 4265 EPTNNDHEEDEIGLNATEGLEVVHADKDSEVPVIEENVVPYHSTTIVGDQTTNDGHEKDK 4086
            E      + +EI        E+     DSE  + EE +VP      + ++  N    K++
Sbjct: 3657 EIKEEQLDSEEIKEEQLVPEEIKEEQLDSE-EIKEEQLVPEE----IKEEQLNSEEIKEE 3711

Query: 4085 GIEKLEIGGADQTTATIGEEPVEDDHGETKVAETLESASAHKDIGEHIIEEDVPDHSRTT 3906
             ++  EI      +  I EE ++ +          E       + E ++EE+        
Sbjct: 3712 QLDSEEIKEEQLDSEEIKEEQLDSE----------EIKEQKGSVNEEVVEEEGSVTEEIK 3761

Query: 3905 ISEEKVIER-LEIIDANKNSGVAITDNNVVLDDSTRTTEQEPTKNGEEENKVIQKLEISS 3729
              EE V E  LE ++  ++    I +  +   +     E+  TK   EE +VI   ++  
Sbjct: 3762 EQEESVNEEVLEEVEETESIKEEIVEGGIATQEIIE--EESDTKEVVEE-EVIDSEKLVD 3818

Query: 3728 ADKVIGDPIIEDVPEHSTTTTGEEPVKEGHKENKVIEQIQILGLDKEIGGPVVEENVAPN 3549
            A  V G+ + E+V      +  +E V+EG    +V+E+ + +  +    G  +++ V   
Sbjct: 3819 AGSVTGEVMPEEV------SVTDEVVEEGSTTEEVLEEQKSVNEEVVEDGLTIDDFVGLQ 3872

Query: 3548 HSTT--VIGEE--AIHDGLEED---ETIDGLQVDSTD-------KVNEEAITKEDLAQE- 3414
             STT  V+ E+  AI   LEE+   E I   QV  T+        VNEE I +  +A+E 
Sbjct: 3873 GSTTEEVVEEDGSAIEKILEEETATEEIVEKQVSVTEDIVEKEGSVNEEIIEEASVAEEI 3932

Query: 3413 -HSTTTTQEKLIEDDHGENKVSTE--LAIGEASRDAVKQITKDGSITELSTVSDIKEMTK 3243
                + T+E + +++    +V  E  L   E   +  K +T++  I E+  VS   E+ +
Sbjct: 3933 IQGGSFTEEIVGQEESATEEVIDEEGLISNEIEEEEEKSVTEE-MIEEVEEVSVDDEVEE 3991

Query: 3242 ENSQEEQMEAKKYEGEVKELDLSTKTYEAPASAQKEETMTPSDEKEQHKNQHADSATDAT 3063
             +  EE +E +  + E+   +LS            EE  + +DE  Q      +S  +  
Sbjct: 3992 VSVAEEIVEEELVDDEILPEELSA------TEDVIEEVRSVTDEIVQE-----ESVCEEI 4040

Query: 3062 TGKTNEKGSEDLNDTSTGLNFEEADMLDGSSSLIPEVYXXXXXXXXXXXXEGTEDGPNSL 2883
              +      E ++D S        D +    S+I +V             E TE     +
Sbjct: 4041 LEQEVSASEEYVDDKSV-----TDDFVGHERSVIQDV-------------ENTESVTEEI 4082

Query: 2882 EGVKKASLHDAESECRELTEL---SEEVNRATSIND-SENNTSKKEQGSIKNLEECIKEE 2715
              V K+ + +A  +   +TE     EE++    + D S      +++GS K+  E  +  
Sbjct: 4083 AEVDKSVIEEAVEKQGSVTEEIVEEEELDTEEVLEDKSVTGDVVEQEGSGKDESEAKESF 4142

Query: 2714 TIDTKLRNHLGDREIQNQEVVASVGLTSEEQNFKPVSLSEKIECLDAENLNKHVDDS-TT 2538
            T +      + + + + + +   +   S  +      LS   E ++ E+L K +++  +T
Sbjct: 4143 TEEVDELKSVKEEDQETEYISREIEEESATEQHSEQELSINKEVVETESLTKDIEEEKST 4202

Query: 2537 THQLQENHAKAGSDFIPENKVHEKDTYS------SKKEEQNVESFETSKEPEIPQSWQER 2376
            T ++ E       + + E    E+DT        S  EE   E   T++E    +S  + 
Sbjct: 4203 TQEILEETQSVNEEIVEE----ERDTDEVLKEKVSPSEEVIEEQASTTEEFLEERSSTDE 4258

Query: 2375 TIDGEKTLIEQ-SERESMKLERSDE--SDSIEVLEHTG------VMDGSHEASTIKEEHS 2223
             ++ E    E+  ERE    E   E  SD+ E++E  G      + +GS     ++EE S
Sbjct: 4259 IVEVEDLFTEEVKEREGSVTEEIVEEGSDTGEIVEEEGSDAEEILEEGSFNEEIVEEEGS 4318

Query: 2222 ----------------------SKIIDTETVEDKKIAEDDAVHDQSTDPCRYETVDRSLV 2109
                                   +I++TE+  ++++ ++ A  +        E V+   V
Sbjct: 4319 ITEEILQGSVTEEFVGQQGSVIEEIVETESAIEERVEDESATEEVDERESVTEVVEEE-V 4377

Query: 2108 NDEKEQKSIELEPELEDDYYHTRAIEQGSNSKNQNXXXXXXXXXXXXEIIQDIIVEEHTA 1929
            +   E     +E  +E++   T  I +   S ++N             +I+++   E T 
Sbjct: 4378 SSSDEVVEGSIEEVIENEGSVTEEILEHEVSADENFVGQAVS------VIEEV---EGTE 4428

Query: 1928 NAAEEVIVQENSPKDDKVSKAP-EGKVKESDIVFMEASDSVRXXXXXXXXXXXXEGPKKS 1752
            +  EEV+ +  S  ++ V  +P E  V+++D V  E  +                   + 
Sbjct: 4429 SVTEEVVEETESVSEEIVEVSPTENVVQQTDSVIEEDVEQKEGSF------------NEE 4476

Query: 1751 IDNFGTTEATLEEITKMETNDKPNYS-STESSLSEEQGMVEIPEKTESNNNETIFATPLT 1575
            ID     +  +EE  K+ T +      S    + E     ++ E + + + E + +T   
Sbjct: 4477 IDIRELGDDGVEEREKISTEEVVGQDKSATGDVEESSSTGDVEEVSSTEDEEEVSSTEGL 4536

Query: 1574 ERLSLQDAETEDGELVDASSLASAKMIATQNQDVDDVKQKKSS----NLTDNRTEDKFTA 1407
            E +S  +   E     D   ++S + +  +    ++VK+ KS     ++ ++   DK + 
Sbjct: 4537 EEVSSTEGLEEVSNTEDVEEVSSTEDVE-EGSVAENVKETKSITEEVSVEEDIITDKVSV 4595

Query: 1406 EN---SEAAAQEK--SDIPVE----TSSIVLQSVDRDTETASVEEITARK-------PSS 1275
            E    +EA+ +E   +++PVE    T  + ++    + +  S EEI           P+ 
Sbjct: 4596 EQEVMAEASVEENILTEVPVEEEIMTEKLSVEDKALNEKIMSEEEIVIEDGNVHEVVPAE 4655

Query: 1274 VDILERNPQEPSKLVSTKEELNKIGTQVMEAPLVEQTKREMNTQKEQDIKLE------ED 1113
            V + E  P       +T  E +  G  V+   +V+        Q + D  +E      +D
Sbjct: 4656 VSVTEEIPGVEE---TTNNESHVKGENVVNEVVVDDNSVNDEIQFDDDSSIEIYTVDSKD 4712

Query: 1112 PATGIENSEQKISIPESDTEKHISEQKDGDVILERGDNTELNXXXXXXXXXXXXXSLKEN 933
                 EN +       SD   HIS +K+ + +       ++              + KEN
Sbjct: 4713 VFHKEENYDSFREEVRSDENIHISRKKNENFV------KKIENEKSSVGHVPTEYTSKEN 4766

Query: 932  QPESEESSLKDHETSDTCVNIKTDILEQEEDPIKKHDQNLEEIKKEMKVDENVLEVQSTD 753
              E   S +            K ++ E+    +K  +  +EE+ +E+   EN++E    D
Sbjct: 4767 IAEEVPSHIM----------FKENVTEEVPKEVKYEENTVEEVFEEVTSKENIIEEAPGD 4816

Query: 752  HSNEINEPCDTTENVT 705
             ++E N   +  E VT
Sbjct: 4817 INSEENIIEEVPEVVT 4832



 Score =  139 bits (351), Expect = 6e-30
 Identities = 325/1561 (20%), Positives = 622/1561 (39%), Gaps = 133/1561 (8%)
 Frame = -2

Query: 4307 EEEVADNSTTTIMEEPTNNDHEEDEIGLNATEGLEVVHADKDSEVPVIEENVVPYHSTTI 4128
            EE   +N    IM+E  N + E+ E G N  E ++    +K+     +E  ++  H   I
Sbjct: 20   EETEKENEIEKIMDE--NKETEQTEEG-NTEEFVQ----EKELNQETLENEIIVDH---I 69

Query: 4127 VGDQTTNDGHEKDKGIEKLEIGGADQTTATIGEEPVEDDHGETKVAETLESASAHKDIGE 3948
              ++ T +  E++  +E+          + I E PVE++ G  K+ E +E       + E
Sbjct: 70   KEEEDTRNVKEQESVLEE----------SPIEELPVENNIG--KINEEVEEFI----LNE 113

Query: 3947 HIIEEDVPDHSRTTISEEKVIERLEIIDANKNSGVAITDNNVVLDDSTRTTEQEPTKNGE 3768
              +EE VP        EE V+E L I            D ++  +++T T  +E T  G+
Sbjct: 114  IPLEEQVPKELPQEEIEEIVVEELPI------------DEHLSSEETTVT--EEDTFKGQ 159

Query: 3767 --EENKVIQKLEISSADKVIGDPIIEDVPEHSTTTTGEEPVKEGH-------KENKVIEQ 3615
               E K +++  +S    V    + E++P    + + E PV+E +       +E  V E+
Sbjct: 160  LINEEKPVEEKSVSEEIPVEEKSVSEEIPVEEKSVSEEIPVEEKNVSEEIPVEEKNVSEE 219

Query: 3614 IQILGLDKEIGGPVVEENVA---PNHSTTVIGEEAIHDGLEEDETIDGLQVDSTDKVNEE 3444
            I +   +     PV EENV+   P     V  E  + +    +E  +G        V+EE
Sbjct: 220  IPVEEKNVSEEIPVEEENVSEEIPVEEENVSEEIPVEEENVSEEIPEGGIAIEDVPVDEE 279

Query: 3443 AITKE--------DLAQEHSTTTTQEKLIEDDHGENKVSTE-------------LAIGEA 3327
             +T+E        D       T  +E  +ED+    ++S+E                GE 
Sbjct: 280  TVTEEITVDEKIYDKLPNEIETVNEEMPVEDETLTEQISSEHERVPEEIIEEKPFTEGEE 339

Query: 3326 SRDAVKQITKDGSITELSTVSDIKEMTKENSQEEQMEAKKYEGEVKELD-LSTKTYEAPA 3150
            +     +I ++G +T+   + + + +T++  +EE+       GE+ E D ++ K  E   
Sbjct: 340  TESLTDEIVEEGVVTD--DIPEEQIITEKVQEEEEF----VTGELSEEDIINEKVQEEDE 393

Query: 3149 SAQK---EETMTPSDEKEQHKNQHADSATDATTGKTNEKGSEDLNDTSTGLNFE-EADML 2982
            S  +   EE +     +E+ ++ + +   D +  K  E      +D     NF  E D  
Sbjct: 394  SVTEELPEEDIINEKVQEEEESAYQEIVQDGSVTKDVEYKELVNDDVRDKENFVIEEDPF 453

Query: 2981 DGSSSLIPEVYXXXXXXXXXXXXEGTEDGPNSLEGVKKASLHDAESECRELTELSEEVNR 2802
             G   LI E                T++ P   E V +    + +S  +E+      V +
Sbjct: 454  KG--QLINE-------GLPVEEEFVTKELPVKEESVFEELTEEDQSVTKEIPVEEHSVFK 504

Query: 2801 ATSINDSENNTSKKEQGSI-KNLEE--CIKEETIDTK-LRNHLGDREIQNQEVVASVGLT 2634
                 +S      +E+GS+ + +EE   +  E  +T+ +   + + E+ N+EV+   G  
Sbjct: 505  EVDEIESVTEEIVEEEGSVNEEVEEEVSVSGEVDETEYVTEEVEETELVNEEVLKEEGSA 564

Query: 2633 SEEQNFKPVSLSEKIECLDAENLNKHVDDSTTTHQLQENHAKAGSDFIPENKVHEKDTYS 2454
            SE+   +  S SEKI  ++ E     V + T + ++ E       +   E  V ++ + +
Sbjct: 565  SEKVVKEEGSASEKI--VEEEG---SVTEETASEEIVEEEGSVTEESSSEEIVEDEGSVT 619

Query: 2453 SKKEEQNVESFETSK-EPEIPQSWQERTIDGEKTLIEQ--SERESMKLERSDESDSIEVL 2283
             +   + +   E S  E    +   E  +   K ++E   S  E +  E    SD ++V 
Sbjct: 620  EESSSEEIVEEEGSVIEESASEVIVEDEVSASKEIVEDEASVTEEVVEEEGAVSDEVQVT 679

Query: 2282 EHTGVMDGSHEASTIKE---EHSSKIIDTETVEDKKIAEDDAVHD------QSTDPCRYE 2130
            E   V D       + E   E  + + D    ED+ + E+ AV +      + T P   E
Sbjct: 680  E--SVEDEIINQGIVDEVIVEQEASVTDEIVKEDESVIEEIAVEETVTEVVEETKPMDEE 737

Query: 2129 TVDR-SLVNDEKEQKSIELEPELEDDYYHTRAIEQGSNSKNQNXXXXXXXXXXXXEIIQD 1953
             VD+ S+V + +E+K+++ E            ++QGS  +N                + +
Sbjct: 738  IVDQGSVVENVEEKKTMDEE-----------IVDQGSVVENVEEKKTMDEEIGDQGSVAE 786

Query: 1952 IIVEEHTANAAEEVIVQENSPKDDKVSKAPEGKVKESDIVFMEASDSVRXXXXXXXXXXX 1773
             + EE      EEVI +E S  +D         VKE+ I   E  + +            
Sbjct: 787  KVEEEEL--VTEEVIEREGSINED--------IVKEASIT--EEVEQIE----------P 824

Query: 1772 XEGPKKSIDNF--GTTEATLEEITKMETNDKPNYSSTESSLSEEQGMVEIPEKTESNNNE 1599
              G  + I++      E  + E  K E  D     +  +S+++E+  VE+   TE    E
Sbjct: 825  VTGKVEKIESITDEIKEQLVPEDIKEEQLDFEEIVAQRASVNDEK--VEVASITEEVEEE 882

Query: 1598 --TIFATPLTERLSLQDAETEDGE----LVDASSLASAKMIATQNQDVDDVKQKKSSNLT 1437
              ++    L E  S  +   E+G     +V+     S +++  +    ++V +++ S +T
Sbjct: 883  EKSVSEEVLEEEGSTTEKVVEEGSSTEVVVEEQGSVSEEVLEEEGSTTEEVVEEQGS-VT 941

Query: 1436 DNRTEDKFTAENSEAAAQEKSDIPVETSSIVLQSVDRDTETASVEEITARKPSSVDILER 1257
            +N  E+    E++     EK +   E  S+  Q+V     + + + +   K     ++  
Sbjct: 942  ENLLEE----ESASQGIVEKEEFVDEEDSVKDQNVFEKEGSVTEQLVEEEK----GLINE 993

Query: 1256 NPQEPSKLVSTKEELNKIGTQVMEAPLVEQ---------TKREMNTQKEQDIKLEEDPAT 1104
            + ++   +    EE+  +  ++ E  L  +         T   +  +K    KL E+ + 
Sbjct: 994  DNEKEELITEMSEEIKSVNEEIEETDLSTEEIIKQQGLATYEFVEEEKSLTDKLLEEESV 1053

Query: 1103 GIENSEQKISIPE------SDTEKHISEQKD-GDVILERGDNTE--LNXXXXXXXXXXXX 951
              E  E ++S  E      S TE+ I E+K   + +LE G  TE  +             
Sbjct: 1054 TKEVGETELSTQEVVDEKVSVTEEVIEEEKSVSEEVLEEGSATEEVVEEGSCTEIVVEKG 1113

Query: 950  XSLKENQPESEESSLKDHETSDTCV-----NIKTDILEQE---EDPIKKHDQNLEEIKKE 795
               +    E   + +   E S T V     ++  ++LE+E    + + +   + + ++K 
Sbjct: 1114 SDTEIVVEEGSATEIVVEEGSATEVVVEEGSVSEEMLEEEGSATEEVVEEGLSSDNVQKS 1173

Query: 794  MKVDENVLEVQS--TDHSNEINEPC----------------DTTENVTIAKKNLE----A 681
              V ENV E+ S  T     +NE                    T+NV++   N E     
Sbjct: 1174 KGVIENVGEIYSVKTAKDESMNEKIPLEKSSFVDDESFKGQGPTDNVSVEDVNSEDIINE 1233

Query: 680  TDPCEELK---KPTETVD----HDQSQ-EVLPEIEKTEVVNDGEIIKDQDTVFAEDRTVE 525
              P EE K    PTE +     H + + E    +   ++  + E  K Q+    E+  VE
Sbjct: 1234 HTPLEETKIEELPTEYITTADIHTRGETETKYNLIYEKINEEVEKAKFQEEKITENIPVE 1293

Query: 524  QSIEEEKENDTLDKAGHKVDVEDQSNDMHHVNH-------------LMKDTXXXXXXXXX 384
            +   E    D + +     +VE + +D + +               + ++          
Sbjct: 1294 R---ESVTEDIVQEPSLAQEVEQKESDTNEIEETKLANEKIIPEVSVTENVVEKEGLDTE 1350

Query: 383  XXXXEGDNIEKQSIEEEAAKCVGVL-DYKTRDKEVKDSDFTSNEGIANATYCKEKTEPDA 207
                E ++I ++ +EEE + C  ++ + ++  +E+ + + +S+E I       E+ E  +
Sbjct: 1351 EVLEEDESITEEIVEEEVSACEEIVEEEESSSEEIVEEEESSSEEIV------EEEESSS 1404

Query: 206  LTCVKELNQSVNASCDTEASIEEVLEQEEVSNTASEDLGEVVTGTELDIPKMDNTTDTCI 27
               V+E           E+S EE++E+EE   ++SE++ E V+ TE  + +  + T+  +
Sbjct: 1405 EEIVEE----------EESSSEEIVEEEE---SSSEEIIEEVSSTEEVLEEEGSVTEEIV 1451

Query: 26   K 24
            +
Sbjct: 1452 E 1452



 Score =  116 bits (291), Expect = 5e-23
 Identities = 247/1205 (20%), Positives = 473/1205 (39%), Gaps = 50/1205 (4%)
 Frame = -2

Query: 3473 VDSTDKVNEEAITKEDLAQEHSTTTTQEKLIEDDHGENKVSTELAIGEASRDAVKQITKD 3294
            ++ T+K NE    ++ + +   T  T+E   E+   E +++ E    E   D +K+    
Sbjct: 19   MEETEKENE---IEKIMDENKETEQTEEGNTEEFVQEKELNQETLENEIIVDHIKEEEDT 75

Query: 3293 GSITELSTV---SDIKEMTKENSQEEQMEAKKYEGEVKELDLSTKTYEAPASAQKEETMT 3123
             ++ E  +V   S I+E+  EN+  +  E  + E  + E+ L  +  +     + EE + 
Sbjct: 76   RNVKEQESVLEESPIEELPVENNIGKINEEVE-EFILNEIPLEEQVPKELPQEEIEEIVV 134

Query: 3122 PSDEKEQHKNQHADSATDATTGK---TNEKGSEDLNDTSTGLNFEEADMLDGSSSLIPEV 2952
                 ++H +    + T+  T K    NE+   +    S  +  EE  +    S  IP  
Sbjct: 135  EELPIDEHLSSEETTVTEEDTFKGQLINEEKPVEEKSVSEEIPVEEKSV----SEEIPVE 190

Query: 2951 YXXXXXXXXXXXXEGTEDGPNSLEGVKKASLHDAESECRELTELSEEVNRATSINDSENN 2772
                           +E+ P   + V +    + ++   E+    EE N +  I   E N
Sbjct: 191  EKSVSEEIPVEEKNVSEEIPVEEKNVSEEIPVEEKNVSEEIPV--EEENVSEEIPVEEEN 248

Query: 2771 TSKKEQGSIKNLEECIKEETIDTKLRNHLGDREIQNQEVVASVGLTSEEQNFKPVSLSEK 2592
             S++     +N+ E I E  I  +        ++   E   +  +T +E+ +    L  +
Sbjct: 249  VSEEIPVEEENVSEEIPEGGIAIE--------DVPVDEETVTEEITVDEKIYD--KLPNE 298

Query: 2591 IECLDAENLNKHVDDSTTTHQLQENHAKAGSDFIPENKVHEKDTYSSKKEEQNVESFETS 2412
            IE ++ E     V+D T T Q+   H +   + I E    E +   S  +E   E   T 
Sbjct: 299  IETVNEE---MPVEDETLTEQISSEHERVPEEIIEEKPFTEGEETESLTDEIVEEGVVTD 355

Query: 2411 KEPEIPQSWQERTIDGEKTLIEQSERESM---KLERSDESDSIEVLEHTGVMDGSHEAST 2241
              PE  Q   E+  + E+ +  +   E +   K++  DES + E+ E   + +   E   
Sbjct: 356  DIPE-EQIITEKVQEEEEFVTGELSEEDIINEKVQEEDESVTEELPEEDIINEKVQEE-- 412

Query: 2240 IKEEHSSKIID----TETVEDKKIAEDDAVHDQST-----DPCRYETVDRSL-VNDEKEQ 2091
             +E    +I+     T+ VE K++  DD V D+       DP + + ++  L V +E   
Sbjct: 413  -EESAYQEIVQDGSVTKDVEYKELVNDD-VRDKENFVIEEDPFKGQLINEGLPVEEEFVT 470

Query: 2090 KSIELEPE------LEDDYYHTRAIEQGSNSKNQNXXXXXXXXXXXXEIIQDIIVEEHTA 1929
            K + ++ E       E+D   T+ I    +S  +              + ++I+ EE + 
Sbjct: 471  KELPVKEESVFEELTEEDQSVTKEIPVEEHSVFKEVDEIES-------VTEEIVEEEGSV 523

Query: 1928 N--AAEEVIVQENSPKDDKVSKAPEGKVKESDIVFMEASDSVRXXXXXXXXXXXXEGPKK 1755
            N    EEV V     + + V++    +V+E+++V  E                     K 
Sbjct: 524  NEEVEEEVSVSGEVDETEYVTE----EVEETELVNEEVLKEEGSASEKVVKEEGSASEKI 579

Query: 1754 SIDNFGTTEATLEEITKMETNDKPNYSSTESSLSEEQGMVEIPEKTESNNNETIFATPLT 1575
              +    TE T  E    E       SS+E  + +E  + E     E    E        
Sbjct: 580  VEEEGSVTEETASEEIVEEEGSVTEESSSEEIVEDEGSVTEESSSEEIVEEEGSVIEESA 639

Query: 1574 ERLSLQDAETEDGELVDASSLASAKMIATQNQDVDDVKQKKS--SNLTDNRTEDKFTAEN 1401
              + ++D  +   E+V+  +  + +++  +    D+V+  +S    + +    D+   E 
Sbjct: 640  SEVIVEDEVSASKEIVEDEASVTEEVVEEEGAVSDEVQVTESVEDEIINQGIVDEVIVEQ 699

Query: 1400 SEAAAQEKSDIPVETSSIVLQSVDRDTETASVEEITARKPSSVDILERNPQEPSKLVSTK 1221
              +   E   I  E  S++ +    +T T  VEE    KP   +I+++       +V   
Sbjct: 700  EASVTDE---IVKEDESVIEEIAVEETVTEVVEET---KPMDEEIVDQG-----SVVENV 748

Query: 1220 EELNKIGTQVMEAPLVEQTKREMNTQKEQ-------DIKLEEDPATGIENSEQKISIPES 1062
            EE   +  ++++   V +   E  T  E+         K+EE+     E  E++ SI E 
Sbjct: 749  EEKKTMDEEIVDQGSVVENVEEKKTMDEEIGDQGSVAEKVEEEELVTEEVIEREGSINED 808

Query: 1061 DTEKHISEQKDGDVILERGDNTELNXXXXXXXXXXXXXSLKENQPESEESSLKDHETSDT 882
              ++    ++   +    G   ++               +KE Q + EE   +    +D 
Sbjct: 809  IVKEASITEEVEQIEPVTGKVEKIESITDEIKEQLVPEDIKEEQLDFEEIVAQRASVNDE 868

Query: 881  CVNIK--TDILEQEE-----DPIKKHDQNLEEIKKEMKVDENVLEVQSTDHSNEINEPCD 723
             V +   T+ +E+EE     + +++     E++ +E    E V+E Q +     + E   
Sbjct: 869  KVEVASITEEVEEEEKSVSEEVLEEEGSTTEKVVEEGSSTEVVVEEQGSVSEEVLEEEGS 928

Query: 722  TTENVTIAKKNLEATDPCEELKKPTETVDHDQSQEVLPEIEKTEVVNDGEIIKDQDTVFA 543
            TTE V             EE    TE +  ++S      +EK E V++ + +KDQ+    
Sbjct: 929  TTEEVV------------EEQGSVTENLLEEESASQ-GIVEKEEFVDEEDSVKDQNVFEK 975

Query: 542  EDRTVEQSIEEEKENDTLDKAGHKVDVEDQSNDMHHVNHLMKDTXXXXXXXXXXXXXEGD 363
            E    EQ +EEEK     D    ++ + + S ++  VN  +++T               +
Sbjct: 976  EGSVTEQLVEEEKGLINEDNEKEEL-ITEMSEEIKSVNEEIEETDLST-----------E 1023

Query: 362  NIEKQS-------IEEEAAKCVGVLDYKTRDKEVKDSDFTSNEGIANATYCKEKTEPDAL 204
             I KQ        +EEE +    +L+ ++  KEV +++ ++ E +       E+      
Sbjct: 1024 EIIKQQGLATYEFVEEEKSLTDKLLEEESVTKEVGETELSTQEVVDEKVSVTEE------ 1077

Query: 203  TCVKELNQSVNASCDTEASIEEVLEQEEVSNTASEDLGEVVTGTELDIPKMDNTTDTCIK 24
              V E  +SV+         EEVLE+     +A+E++ E  + TE+ + K  +T     +
Sbjct: 1078 --VIEEEKSVS---------EEVLEE----GSATEEVVEEGSCTEIVVEKGSDTEIVVEE 1122

Query: 23   GGDIE 9
            G   E
Sbjct: 1123 GSATE 1127



 Score = 94.7 bits (234), Expect = 2e-16
 Identities = 188/902 (20%), Positives = 363/902 (40%), Gaps = 64/902 (7%)
 Frame = -2

Query: 4820 DKGIGEPVI--EEDVIQDQYTPTIGEEPTKECHEKEKVIEESKFDANKNIEEPTIEENDH 4647
            DK + +  +  E  VIQD       E  T+E  E +K + E   +   ++ E  +EE + 
Sbjct: 4054 DKSVTDDFVGHERSVIQDVENT---ESVTEEIAEVDKSVIEEAVEKQGSVTEEIVEEEEL 4110

Query: 4646 STTTILE-KTI-----------RDAHENDKAVEDAIIE-------DVVMDYPKKAITEET 4524
             T  +LE K++           +D  E  ++  + + E       D   +Y  + I EE+
Sbjct: 4111 DTEEVLEDKSVTGDVVEQEGSGKDESEAKESFTEEVDELKSVKEEDQETEYISREIEEES 4170

Query: 4523 LKDGLEENKVIEGRNIVGAD---KDIDDPFIVEDDKCDVTATTRENSIKDGHEEDKVIDE 4353
              +   E ++   + +V  +   KDI++      +  + T +  E  +++  + D+V+ E
Sbjct: 4171 ATEQHSEQELSINKEVVETESLTKDIEEEKSTTQEILEETQSVNEEIVEEERDTDEVLKE 4230

Query: 4352 V-----KIVEADNDTSEHVREEEVADNSTTTIMEEPTNNDHEEDEIGLNATEGLEVVHAD 4188
                  +++E    T+E   EE    +ST  I+E       E  E   + TE  E+V   
Sbjct: 4231 KVSPSEEVIEEQASTTEEFLEER---SSTDEIVEVEDLFTEEVKEREGSVTE--EIVEEG 4285

Query: 4187 KDSEVPVIEENVVPYHSTTIVGDQTTNDGHEKDKGIEKLEIGGADQTTATIG------EE 4026
             D+   V EE      +  I+ + + N+   +++G    EI     T   +G      EE
Sbjct: 4286 SDTGEIVEEEGS---DAEEILEEGSFNEEIVEEEGSITEEILQGSVTEEFVGQQGSVIEE 4342

Query: 4025 PVEDDHGETKVAETLESASAHKDIGEH-----IIEEDVPDHSRTTI-SEEKVIERL---- 3876
             VE    E+ + E +E  SA +++ E      ++EE+V         S E+VIE      
Sbjct: 4343 IVET---ESAIEERVEDESATEEVDERESVTEVVEEEVSSSDEVVEGSIEEVIENEGSVT 4399

Query: 3875 -EIIDANKNSGVAITDNNVVLDDSTRTTEQEPTKNGEEENKVIQKL-EISSADKVIG--D 3708
             EI++   ++        V + +    TE    +  EE   V +++ E+S  + V+   D
Sbjct: 4400 EEILEHEVSADENFVGQAVSVIEEVEGTESVTEEVVEETESVSEEIVEVSPTENVVQQTD 4459

Query: 3707 PIIEDVPEHSTTTTGEE-PVKE----GHKENKVIEQIQILGLDKEIGGPVVEENVAPNHS 3543
             +IE+  E    +  EE  ++E    G +E + I   +++G DK   G V E +     S
Sbjct: 4460 SVIEEDVEQKEGSFNEEIDIRELGDDGVEEREKISTEEVVGQDKSATGDVEESS-----S 4514

Query: 3542 TTVIGEEAIHDGLEEDETIDGLQVDSTDKVNEEAITKEDLAQEHSTTTTQEKLIEDDHGE 3363
            T  + E +  +  EE  + +GL+  S+ +  EE    ED+ +  ST   +E  + ++  E
Sbjct: 4515 TGDVEEVSSTEDEEEVSSTEGLEEVSSTEGLEEVSNTEDVEEVSSTEDVEEGSVAENVKE 4574

Query: 3362 NKVSTELAIGEASRDAVKQITKDGSITELSTVSDIKEMTKENSQEEQMEAKKYEGEVKEL 3183
             K  TE    E      K   +   + E S   +I  +T+   +EE M  K     V++ 
Sbjct: 4575 TKSITEEVSVEEDIITDKVSVEQEVMAEASVEENI--LTEVPVEEEIMTEKL---SVEDK 4629

Query: 3182 DLSTKTYEAPASAQKEETMTPSDEKEQHKNQHADSATDATTGKTNEKGSEDLNDTSTGLN 3003
             L+ K         ++  +      E    +      + T  +++ KG   +N+     N
Sbjct: 4630 ALNEKIMSEEEIVIEDGNVHEVVPAEVSVTEEIPGVEETTNNESHVKGENVVNEVVVDDN 4689

Query: 3002 -FEEADMLDGSSSLIPEVYXXXXXXXXXXXXEGTEDGPNSLEGVKKASLHDAESECRELT 2826
               +    D  SS+  E+Y                   +S +   K   +D+    RE  
Sbjct: 4690 SVNDEIQFDDDSSI--EIYTV-----------------DSKDVFHKEENYDS---FREEV 4727

Query: 2825 ELSEEVNRATSINDSENNTSKKEQGSIKNL-EECIKEETIDTKLRNHLGDREIQNQEVVA 2649
               E ++ +   N++     + E+ S+ ++  E   +E I  ++ +H+  +E   +EV  
Sbjct: 4728 RSDENIHISRKKNENFVKKIENEKSSVGHVPTEYTSKENIAEEVPSHIMFKENVTEEVPK 4787

Query: 2648 SVGL--TSEEQNFKPVSLSEKI------ECLDAENLNKHVDDSTTTHQLQENHAKAGSDF 2493
             V     + E+ F+ V+  E I      +    EN+ + V +  T+ ++           
Sbjct: 4788 EVKYEENTVEEVFEEVTSKENIIEEAPGDINSEENIIEEVPEVVTSEEI----------- 4836

Query: 2492 IPENKVHEKDTYSSKKEEQNVESFETSKEPEIPQSWQERTIDGEKTLIEQSERESMKLER 2313
            + +N V+  +T      + +++      E +   +     +D    +IE+ +R+  K  +
Sbjct: 4837 VVQNDVNNINTNIDHMFDFDLDDILKIPEAQRKLNKLRTLVDVHLDVIEKMQRDEWKKNK 4896

Query: 2312 SD 2307
             D
Sbjct: 4897 RD 4898


>ref|XP_001348162.2| Antigen 332, DBL-like protein [Plasmodium falciparum 3D7]
            gi|254832737|gb|AAN36075.2| Antigen 332, DBL-like protein
            [Plasmodium falciparum 3D7]
          Length = 6093

 Score =  189 bits (479), Expect = 9e-45
 Identities = 362/1720 (21%), Positives = 701/1720 (40%), Gaps = 90/1720 (5%)
 Frame = -2

Query: 4892 TEEKSINDGREKDKITAGLAIANADKGIGEPVIEE---DVIQDQYTPTIGEEPTKECHEK 4722
            T+  S+ D   +D       I N    + E  IEE   + I      T GE  TK     
Sbjct: 1799 TDNVSVEDVNSED-------IINEHTPLEETKIEELPTEYITTADIHTKGETETKYNLIY 1851

Query: 4721 EKV---IEESKFDANKNIEEPTIEENDHSTTTILEKTIRDAHENDKAVEDAIIEDVVMDY 4551
            EK+   +E++KF   K  E   +E    +   + E ++    E  ++  + I E  + + 
Sbjct: 1852 EKINEEVEKAKFQEEKITENIPVERESVTEDIVQEPSLAQEVEQKESDTNEIEETKLAN- 1910

Query: 4550 PKKAITEETLKDGLEENKVIEGRNIVGADKDIDDPFIVEDDKCDVTATTRENSIKDGHEE 4371
             +K I E ++ + + E + ++   ++  D+ I +  + E+          E S  +   E
Sbjct: 1911 -EKIIPEVSVTENVVEKEGLDTEEVLEEDESITEEIVEEEVSSSEEIVEEEESSSEEIVE 1969

Query: 4370 DKVIDEVKIVEADNDTSEHVREEEVADNSTTTIMEEPTNNDHEEDEIGLNATEGLEVVHA 4191
            ++     +IVE +  +SE + EEE  ++S+  I+EE  ++  E  E  +++TE  EV+  
Sbjct: 1970 EEESSSEEIVEEEESSSEEIVEEE--ESSSEEIVEEEESSSEEIIE-EVSSTE--EVLEE 2024

Query: 4190 DKDSEVPVIEENVVPYHSTTIVGDQTTNDGHEKDKGIEKLEIGGADQTTATIGEEPVEDD 4011
            +      ++EE V        +G  +     E+  G E+  +G       ++ EE VE +
Sbjct: 2025 EGSVTEEIVEEEVSTTEEVKDIGSVSEEVLEEEGFGTEEF-VG----QQGSVIEEIVETE 2079

Query: 4010 HGETKVAETL-----ESASAHKDIGEHIIEEDVP--------DHSRT--------TISEE 3894
                KV E +     E       + + I+ E+V         D S T        ++SEE
Sbjct: 2080 SSTEKVLEDVGSNVEEIVQEEGPVAQEIVHEEVSTTEKHDEVDRSTTEEIVEKVGSVSEE 2139

Query: 3893 KVIERLEIIDANKNSGVAITDNNVVLDDSTRTTEQEPTKNGEEENKVIQKLEISSADKVI 3714
             ++E +   +     G ++T+   V+++     E   T++  EE  ++QK E+S A++V+
Sbjct: 2140 IIVEEVSASEEIVEEG-SVTEE--VVEEEKLINEVGETESVTEE--IVQK-EVSDAEEVL 2193

Query: 3713 G------------DPIIEDV--PEHSTTTTGEEPVKEGHKENKVIEQIQILGLDKEIGGP 3576
            G            + I+E++  PE S T   EE V  G    +V E+  +     +  G 
Sbjct: 2194 GQEGSMNEEILEKESIVEEIVGPEGSVT---EEIVDHGSFAEEVKEEELVTEEAVQYEGS 2250

Query: 3575 VVEENVAPNHSTT---VIGEEAIHDGLEE-----DETIDGLQVDSTDKVNEEAITKEDLA 3420
            V EE +    S T    I E A  + +EE     DE +    +D+ + VNE ++T E   
Sbjct: 2251 VTEE-IKEEESITENEAIEESAFAEIIEEKGPNTDEIVKEEGLDTEEIVNEVSVTDE--- 2306

Query: 3419 QEHSTTTTQEKLI-EDDHGENKVSTELAIGEASRDAVKQ-ITKDGSITELSTVSDIKEMT 3246
                    +EKL+ E   GE +  TE  + E  R A +  + ++ S+TE   VS  +  T
Sbjct: 2307 -----VIEEEKLVNEQIVGEERSVTEKPV-EVERSATEDLVEEEASVTE--KVSVHEGST 2358

Query: 3245 KENSQEEQMEAKKYEGEVKELDLSTKTYEAPASAQKEETMTPSDEKEQHKNQHADSATDA 3066
             E   +E +  +  E EV   D   +   +     +EE     +  E+ ++   +   + 
Sbjct: 2359 TEQILDESVAEEIVEEEVSVDDKIIEEEVSVDEVVEEEGSVIEEIVEEEESVPEEILEEE 2418

Query: 3065 TTGKTNEKGSEDLNDTSTG----LNFEEADMLDGSSSLIPEVYXXXXXXXXXXXXEGTED 2898
             +G       E + D   G    +  E  +++DG  S+  E+                ED
Sbjct: 2419 LSGSEEVLEDEWVTDAFMGQEGSVIEEIEEIVDGEGSITEEI---------------VED 2463

Query: 2897 GPNSLEGVKKASLHDAESECRE---LTELSEEVNRATSINDSENNTSKKEQGS-IKNLEE 2730
            G  + + V++      E   +E   + E+ EE +    + D++  + K E+ S I+ ++E
Sbjct: 2464 GSANEKIVEEEPSRVEEVLGKEGFVIEEIIEEGSVIEQVEDTKTVSEKSEESSAIEEVKE 2523

Query: 2729 CIKEETIDTKLRNHLGDREIQNQEVVASVGLTSEEQNFKPVSLSEKI--ECLDAENLNKH 2556
              +EE+I  K+        ++ +E V    +  EE      S +EKI  +    E+  + 
Sbjct: 2524 VKEEESISEKI--------VEKEESVTEEIVRQEE------STTEKIVKDVSPTEDFVEQ 2569

Query: 2555 VDDSTTTHQLQENHAKAGSDFIPENKVHEKDTYSSKKEEQNVESFETSKEPEIPQSWQER 2376
             D  T     QE     GS+      V EK++ S + E+++V     ++     +S  + 
Sbjct: 2570 TDSVTEKVIEQE-----GSNTEVAEDVEEKESASDEHEQEDVS--VNAQVTYEKKSVTKE 2622

Query: 2375 TIDGEKTLIEQSERESMKLERSDESDSI--EVLEHTGVMDGSHEASTIKEE--HSSKIID 2208
             +D      E  E      E  DE+ S+  E++E   V +   E  ++ EE      +I 
Sbjct: 2623 IVDEVSRTEEIVEENGSVTEGVDETGSVTEEIIEEATVTEEVVEDGSVTEEVVEDGSVIQ 2682

Query: 2207 TETVEDKKIAEDDAVHDQSTDPCRYETVDRSLVNDEKEQKSIELEPELEDDYYHTRAIEQ 2028
             E VED  + E+     Q       E V+     +E+ ++ + +  E+++  Y T  +E+
Sbjct: 2683 -EVVEDGSVTEEIV---QENGSVTEEIVEEEGSVNEEVEEEVSVSGEVDETEYVTEEVEE 2738

Query: 2027 GSNSKNQNXXXXXXXXXXXXEIIQDIIVEEHTANA-------AEEVIVQENSPKDDKVSK 1869
              +                  ++++I+ EE + +          E + +E S  ++ V +
Sbjct: 2739 EGS------------------VVEEIVEEEGSVSGEVDETEYVTEEVEEEGSVVEEIVEE 2780

Query: 1868 --APEGKVKESDIVFMEASDSVRXXXXXXXXXXXXEGPKKSIDNFGTTEATLEEITKMET 1695
              +  G+V E++ V  E  +                G     +    TE   EE + +E 
Sbjct: 2781 EGSVSGEVDETEYVTEEVEEEGSVVEEIVEEEGSVSGEVDETEY--VTEEVEEEGSVVEE 2838

Query: 1694 NDKPNYSSTESSLSEEQGMVEIPEKTESNNNETIFATPLTERLSLQDAETEDGELVDASS 1515
              +   S  E  + EE  + E+ ++TE  N+E +   P TE   +++  + + E+++ +S
Sbjct: 2839 IVEEEGSVVEEIVEEEGSVSEVVDETELVNDEIVEQAPFTE--EVEEQVSVNDEIIEDAS 2896

Query: 1514 LASAKMIATQNQDVDDVKQKKSSNLTDNRTEDKFTAENSEAAAQEKSDIPVETSSIVLQS 1335
            +A A         V++ +    S   +  TE  F  E  E       +I  +   ++ + 
Sbjct: 2897 VAEA---------VEESESITESVSQEEETEKGFVIEKVEETGAVTEEIVQD--GLITEE 2945

Query: 1334 VDRDTETASVEEITARKPSSVDILER---NPQEPSKLVSTKEEL-NKIGTQVMEAPLVEQ 1167
            +  ++E+ +  EI  ++  + +ILE      +   +  ST EE+  + G+   E    E 
Sbjct: 2946 ILEESESVN-GEIINKESDAEEILETEFLTEEVVGQAGSTSEEIVEEEGSVTKEVEEKES 3004

Query: 1166 TKREMNTQKEQDIKLEEDPATGIENSEQKISIPESDTEKHISEQKDGDVILERGDNTELN 987
               E+  +     +L ++ +   E  EQ  SI     ++ + E+   + I+    N E  
Sbjct: 3005 VTEELVDEGSVTEELVDEGSVTEEVVEQGGSI----AQEIVEEESATEEIIRDETNVE-- 3058

Query: 986  XXXXXXXXXXXXXSLKENQPESEESSLKDHETSDTCVNIKTDILEQ--------EEDPIK 831
                          + E +  + E  ++D   ++  V  +  ++E+         E+ +K
Sbjct: 3059 -------------EVLEKEGSATEEIVQDGSGTNDFVGKQGSVIEEVVEEEISTTEEKLK 3105

Query: 830  KHDQNLEEIKKEMKVDENVLEVQSTDHSNEINEPCDTTENVTIAKKNLEATDPCEELKKP 651
            +    +EE  +E  + E+VLE +S    N + +    TE +   + +    D  EE +  
Sbjct: 3106 EEASAIEEFVEEESIREDVLE-ESLVTENVVGQQESVTEEIVDGEGSF-TEDIVEEEESV 3163

Query: 650  TETVDHDQSQEVLPEIEKTEVVNDGEIIKDQDTVFAEDRTVEQSIEEEK-ENDTLDKAGH 474
            TE +  D+       +E  E+V + EI++D+ +   E    E S  EE  E  +L +   
Sbjct: 3164 TEEIVVDEESVTKEIVEDEELVTE-EIVEDEGSFTEEIVEDEGSFTEEVIEERSLIEEVE 3222

Query: 473  KVDVEDQSNDMHHVNHLMKDTXXXXXXXXXXXXXEGDNIEKQSIEEEAAKCVGVLDYKTR 294
              +   +  +   +  ++ +                +  EK+S++EE  +   V++ +  
Sbjct: 3223 DTETVAEKEEGSVIKEIIDEKSLTEKIVEEEKSVTEEVEEKESVKEEVEEQRLVVEEEGS 3282

Query: 293  DKEVKDSDFTSNEGIANATYCKEKTEPDALTC---VKELNQSVNASCDTEASIEEVLEQE 123
              E    D  + EGI +     E+   D L     V++    +    D E S+ E + +E
Sbjct: 3283 ATEGIVEDRLATEGIVDDILVTEEIVEDGLATDEFVEQQGSIIEEVLDDEGSVTEEIVEE 3342

Query: 122  EVSNTASEDLGEVVTGTELDIPKMDNTTDTCIKGGDIERM 3
            E   + +E++ E V+  E D   ++  ++  ++G   E M
Sbjct: 3343 E--GSPNEEIVEGVSVIEED-DNIEPVSEEIVEGSVTEEM 3379



 Score =  167 bits (422), Expect = 3e-38
 Identities = 386/1832 (21%), Positives = 713/1832 (38%), Gaps = 237/1832 (12%)
 Frame = -2

Query: 4886 EKSINDGREKDKITAGLAIANA-DKGIGEPVIEEDVIQDQYTPTIGEEPTKECHEKEKVI 4710
            EK +++ +E ++   G       +K + +  +E ++I D       EE T+   E+E V+
Sbjct: 615  EKIMDENKETEQTEEGNTEEFVQEKELNQETLENEIIVDHIKE---EEDTRNVKEQESVL 671

Query: 4709 EESKFDANKNIEEPTIEENDHSTTTILEKTIRDAHENDKAVEDAIIEDVVMD--YPKKAI 4536
            EES       IEE  +E N                + ++ VE+ I+ ++ ++   PK+  
Sbjct: 672  EESP------IEELPVENN--------------IGKINEEVEEFILNEIPLEEQVPKELP 711

Query: 4535 TEETLKDGLEENKVIEGRNIVGADKDIDDPFIVEDDKCDVTATTRENSIKDGHEEDKVID 4356
             EE  +  +EE  + E  +        ++  + E+D         E  +++    +++  
Sbjct: 712  QEEIEEIVVEELPIDEHLSS-------EETTVTEEDTFKGQLINEEKPVEEKSVSEEIPV 764

Query: 4355 EVKIVEADNDTSEHVREEEVADNSTTTIMEEPTNNDHEEDEIGL---NATEGLEVVHADK 4185
            E K V  +    E    EE+     +   E P    +  +EI +   N +E + V   + 
Sbjct: 765  EEKSVSEEIPVEEKSVSEEIPVEEKSVSEEIPVEEKNVSEEIPVEEKNVSEEIPVEEKNV 824

Query: 4184 DSEVPVIEENV-------------VPYHSTTIVGDQTTNDGHEKDKGIEKLEIGGADQTT 4044
              E+PV EENV             VP    T+  ++ T D    DK   ++E        
Sbjct: 825  SEEIPVEEENVSEEIPEGGIAIEDVPVDEETVT-EEITVDEKIYDKLPNEIE-------- 875

Query: 4043 ATIGEE-PVEDDHGETKVAETLESASAHKDIGEHIIEE---------------------- 3933
             T+ EE PVED+        T + +S H+ + E IIEE                      
Sbjct: 876  -TVNEEMPVEDE------TLTEQISSEHERVPEEIIEEKPFTEGEETESLTDEIVEEGVV 928

Query: 3932 --DVPDHSRTTISEEKVIERLEIIDANKNSGVAITDNNVVLDDSTRTTEQEPTKNGEEE- 3762
              D+P+    T   EKV E  E +    +    I  N  V ++    TE+ P    EE+ 
Sbjct: 929  TDDIPEEQIIT---EKVQEEEEFVTGELSEEDII--NEKVQEEDESVTEELP----EEDI 979

Query: 3761 -NKVIQKLEISSADKVIGDPIIEDVPEHSTTTTGEEPVKEGHKENKVIEQIQILGLDKEI 3585
             N+ +Q+ E S+  +++ D  +    E+      +  V++  KEN VIE+    G     
Sbjct: 980  INEKVQEEEESAYQEIVQDGSVTKDVEYKELVNDD--VRD--KENFVIEEDPFKGQLINE 1035

Query: 3584 GGPVVEENVAPNHSTTVIGEEAIHDGLEEDETIDGLQVDSTDKVNEEAITKEDLAQEHST 3405
            G PV EE V        + EE++ + L E++               +++TKE   +EHS 
Sbjct: 1036 GLPVEEEFVTKE---LPVKEESVFEELTEED---------------QSVTKEIPVEEHSV 1077

Query: 3404 -------TTTQEKLIEDDHGEN-KVSTELAI----------------------------G 3333
                    +  ++++E++   N +V  E+++                            G
Sbjct: 1078 FKEVDEIESVTDEIVEEEGSVNEEVEEEVSVSGEVDETEYVTEEVEETELVNEEVLKEEG 1137

Query: 3332 EASRDAVKQ--------ITKDGSITELSTVSDIKE----MTKENSQEEQMEAKKYEGEVK 3189
             AS   VK+        + ++GS+TE +   +I E    +T+E+S EE +E    EG V 
Sbjct: 1138 SASEKVVKEEGSASEKIVEEEGSVTEETASEEIVEEEGSVTEESSSEEIVED---EGSVT 1194

Query: 3188 ELDLSTKTYEAPASAQKEET--MTPSDEKEQHKNQHADSATDATTGKTNEKG-------- 3039
            E   S +  E   S  +E    +   DE    K    D A+  T     E+G        
Sbjct: 1195 EESSSEEIVEEEGSVIEESASEVIVEDEVSASKEIVEDEAS-VTEEVVEEEGAVSDEVQV 1253

Query: 3038 SEDLNDTSTGLNFEEADMLDGSSSLIPEVYXXXXXXXXXXXXEGT------EDGPNSLEG 2877
            +E + D        +  +++  +S+  E+             E T      E  P   E 
Sbjct: 1254 TESVEDEIINQGIVDEVIVEQEASVTDEIVKEDESVIEEIAVEETVTEVVEETKPMDEEI 1313

Query: 2876 VKKASLHDAESECRELTELSEEVNRATSI-NDSENNTSKKEQGSIKNLEECIKEETIDTK 2700
            V + S+ +   E + + E  E V++ + + N  E  T  +E G   ++ E ++EE + T+
Sbjct: 1314 VDQGSVVENVEEKKTMDE--EIVDQGSVVENVEEKKTMDEEIGDQGSVAEKVEEEELVTE 1371

Query: 2699 LRNHLGDREIQ-NQEVVASVGLTSEEQNFKPVS-LSEKIECLDAENLNKHVDDSTTTHQL 2526
                + +RE   N+++V    +T E +  +PV+   EKIE +  E   + V +     QL
Sbjct: 1372 ---EVIEREGSINEDIVKEASITEEVEQIEPVTGKVEKIESITDEIKEQLVPEDIKEEQL 1428

Query: 2525 QENHAKAGSDFIPENKVHEKDTYSSKKEEQNVESFETSKEPEIPQSWQERTIDGEKTLIE 2346
                  A    + + KV         +EE+   S E  +E     S  E+ + G  T + 
Sbjct: 1429 DFEEIVAQRASVNDEKVEVASITEEVEEEEKSVSEEVLEE---EGSTTEKVVKGSSTEVV 1485

Query: 2345 QSERESM----------------KLERSDESDSIE---VLEHTG---------------- 2271
              E+ S+                K E  DE DS++   V E  G                
Sbjct: 1486 VEEQGSVTENLLEEESASQGIVEKEEFVDEEDSVKDQNVFEKEGSVTEQLVEEEKGLINE 1545

Query: 2270 -------VMDGSHEASTIKEEHSSKIIDTET------------VEDKKIAEDDAVHDQS- 2151
                   + + S E  ++ EE     + TE             VE++K   D  + ++S 
Sbjct: 1546 DNEKEELITEMSEEIKSVNEEIEETDLSTEEIIKQQGLATYEFVEEEKSLTDKLLEEESV 1605

Query: 2150 ------TDPCRYETVDRSL-VNDE--KEQKSIELEPELEDDYYHTRAIEQGSNSKNQNXX 1998
                  T+    E VD  + V +E  +E+KS+  E  LE+       +E+GS ++     
Sbjct: 1606 TKEVGETELSTQEVVDEKVSVTEEVIEEEKSVS-EEVLEEGSATEEVVEEGSCTEVVVEE 1664

Query: 1997 XXXXXXXXXXEIIQDIIVEEHT-------ANAAEEVIVQENSPKDDKVSKAPEGKVKESD 1839
                          +I+VE+ +         +A E++V+E S  +  V    EG   E  
Sbjct: 1665 GSCTEVVVEEGSCTEIVVEKGSDTEIVVEEGSATEIVVEEGSATEVVVE---EGSATEE- 1720

Query: 1838 IVFMEASDSVRXXXXXXXXXXXXEGPKKSIDNFGTTEATLEEITKMETNDKPNYSSTESS 1659
             V  E S S                   S DN   ++  +E + ++ +      ++ + S
Sbjct: 1721 -VVEEGSVSEEMLEEEGSATEEVVEEGLSSDNVQKSKGVIENVGEIYSVK----TAKDES 1775

Query: 1658 LSEEQGMVEIP-EKTESNNNETIFATPLTERLSLQDAETEDGELVDASSLASAKM--IAT 1488
            ++E     +IP EK+   ++E+      T+ +S++D  +ED  + + + L   K+  + T
Sbjct: 1776 MNE-----KIPLEKSSFVDDESFKGQGPTDNVSVEDVNSED-IINEHTPLEETKIEELPT 1829

Query: 1487 QNQDVDDVKQKKSSNLTDNRTEDKFTAENSEAAAQEK---SDIPVETSSIVLQSVDRDTE 1317
            +     D+  K  +    N   +K   E  +A  QE+    +IPVE              
Sbjct: 1830 EYITTADIHTKGETETKYNLIYEKINEEVEKAKFQEEKITENIPVERE------------ 1877

Query: 1316 TASVEEITARKPSSVDILERNPQEPSKLVSTKEELNKIGTQV-MEAPLVEQTKREMNTQK 1140
              SV E   ++PS    +E+   + +++  TK    KI  +V +   +VE+   +     
Sbjct: 1878 --SVTEDIVQEPSLAQEVEQKESDTNEIEETKLANEKIIPEVSVTENVVEKEGLDTEEVL 1935

Query: 1139 EQDIKL-EEDPATGIENSEQKISIPESDTEKHISEQKDG--DVILERGDNTELNXXXXXX 969
            E+D  + EE     + +SE+ +   ES +E+ + E++    +++ E   ++E        
Sbjct: 1936 EEDESITEEIVEEEVSSSEEIVEEEESSSEEIVEEEESSSEEIVEEEESSSE-------- 1987

Query: 968  XXXXXXXSLKENQPESEESSLKDHETSDTC---VNIKTDILEQE----EDPIKKHDQNLE 810
                    ++E +  SEE   ++  +S+     V+   ++LE+E    E+ +++     E
Sbjct: 1988 ------EIVEEEESSSEEIVEEEESSSEEIIEEVSSTEEVLEEEGSVTEEIVEEEVSTTE 2041

Query: 809  EIKKEMKVDENVLEVQSTDHSNEINEPCDTTENVTIAKKNLEAT-----DPCEEL----- 660
            E+K    V E VLE +       + +     E +   + + E          EE+     
Sbjct: 2042 EVKDIGSVSEEVLEEEGFGTEEFVGQQGSVIEEIVETESSTEKVLEDVGSNVEEIVQEEG 2101

Query: 659  --------KKPTETVDHDQSQEVLPE--IEKTEVVNDGEIIKD---QDTVFAEDRTVEQS 519
                    ++ + T  HD+      E  +EK   V++  I+++    + +  E    E+ 
Sbjct: 2102 PVAQEIVHEEVSTTEKHDEVDRSTTEEIVEKVGSVSEEIIVEEVSASEEIVEEGSVTEEV 2161

Query: 518  IEEEKENDTLDKAGHKVDVEDQSNDMHHVNHLMKDTXXXXXXXXXXXXXEGDNIEKQSIE 339
            +EEEK    +++ G    V ++         + K+                + +EK+SI 
Sbjct: 2162 VEEEK---LINEVGETESVTEEI--------VQKEVSDAEEVLGQEGSMNEEILEKESIV 2210

Query: 338  EEAAKCVG-----VLDYKTRDKEVKDSDFTSNEGIA-NATYCKEKTEPDALTCVKELNQS 177
            EE     G     ++D+ +  +EVK+ +  + E +    +  +E  E +++T  + + +S
Sbjct: 2211 EEIVGPEGSVTEEIVDHGSFAEEVKEEELVTEEAVQYEGSVTEEIKEEESITENEAIEES 2270

Query: 176  VNASC-------DTEASIEEVLEQEEVSNTAS 102
              A           E   EE L+ EE+ N  S
Sbjct: 2271 AFAEIIEEKGPNTDEIVKEEGLDTEEIVNEVS 2302



 Score =  166 bits (421), Expect = 5e-38
 Identities = 341/1711 (19%), Positives = 709/1711 (41%), Gaps = 109/1711 (6%)
 Frame = -2

Query: 4817 KGIGEPVIEEDVIQDQYTPTIGEEPTKECHEKEKVIEESKFDANKNIEEPTIEE------ 4656
            + + E V+EE+   D+         T+E  + E  +EE   +     EE  +EE      
Sbjct: 3767 ESVTEEVVEEEGPVDEEIVQEEGSVTEEIIQGESKVEEVVEEQGSENEEIFVEEVSASQE 3826

Query: 4655 ---NDHSTTTILEKT------IRDAHENDKAVED--AIIEDVVMDYPKKAITEETLKDGL 4509
               N+  T  ILEK       ++D    ++ +E+   + E+VV +  +++IT E +++  
Sbjct: 3827 IVQNESGTEEILEKVSASQEIVQDGSVTEQIIEEQKPVTEEVVNE--EESITHEIIQEES 3884

Query: 4508 EENKVIEGRNIVGADKDIDDPFIVEDDKCDVTATTRENSIKDGHEEDKVIDE-----VKI 4344
               KV++  ++  A++ +++P  V ++  +   +  E+  ++G+  +++++E      +I
Sbjct: 3885 HVEKVVQQGSV--AEEVVENPVSVTEEIVEKEGSVTEDIGQEGYVAEEIVEEEEFDNEEI 3942

Query: 4343 VEADNDTSEHVRE---------EEVADNSTTTIMEEPTNNDHEEDEIGLNATEGLEVVHA 4191
            +E ++   E V E         E+++D+    + EE + N+   +E G    E LE    
Sbjct: 3943 LEEESVAEEFVEEGFDNEEIFVEQISDSE--IVKEENSVNEEVLEEEGSYTEEILE---- 3996

Query: 4190 DKDSEVPVIEENVVPYHSTTIVGDQTTNDGHEKDKGIEKLEIGGADQTTATIGEEPVEDD 4011
            ++ S    I E    +    +  + + N+   +++G    EI    +   +  EE +E++
Sbjct: 3997 EEGSYTEEILEEEGSFTEEILEEEGSYNEEILEEEGSYNEEI---LEEEGSYNEEILEEE 4053

Query: 4010 HGETKVAETLESASAHKDIGEHIIEEDVPDHSRTT-------ISEEKVIERLEIIDANKN 3852
                +     E ++    +G+    E++ +    T          E++IE     D    
Sbjct: 4054 GSYNEEILEEEGSATDYFVGQGSDNEEIIEEGSATDYFVGQGSDNEEIIEEGSATDYFVG 4113

Query: 3851 SGVAI--------TDNNVVLDDSTRTTEQEPTKNGEE--------ENKVIQKLEISSADK 3720
             G  I         D   V ++    TE E T++  E           ++++  I+   K
Sbjct: 4114 QGSIIEEVLEEEGLDTEKVFENEGSATEFEETESFTEVVEETESVNENILEETSINEVQK 4173

Query: 3719 VIGDPIIEDVPEHSTTTTGEEPVKEGHKENKVIEQIQILGLDKEIGGPVVEENVAPNHST 3540
            +  + I ED+ E        E +KE   +++ I++ Q   LD E    + EE + P    
Sbjct: 4174 I--ESITEDIKEQLV----PEEIKEEQLDSEEIKEEQ---LDSE---EIKEEQLVP---- 4217

Query: 3539 TVIGEEAIHDGLEEDETIDGLQVDSTDKVNEEAITKEDLAQEH--STTTTQEKLIEDDHG 3366
                 E I +   + E I   Q+DS +++ EE +  E++ +E   S    +E+L+ ++  
Sbjct: 4218 -----EEIKEEQLDSEEIKEEQLDS-EEIKEEQLDSEEIKEEQLDSEEIKEEQLVPEEIK 4271

Query: 3365 ENKVSTELAIGEASRDAVKQITKDGSITELSTVSDIKE--MTKENSQEEQMEAKKYEGEV 3192
            E ++ +E            +I ++  + E     +IKE  +  E  +EEQ++++    E+
Sbjct: 4272 EEQLDSE------------EIKEEQLVPE-----EIKEEQLDSEEIKEEQLDSE----EI 4310

Query: 3191 KELDLSTKTYEAPASAQKEETMTPSDEKEQHKNQHADSATDATTGKTNEKGS--EDLNDT 3018
            KE  L ++         KEE +   + KEQ  + + +           E+GS  E++ + 
Sbjct: 4311 KEEQLDSEEI-------KEEQLDSEEIKEQKGSVNEE--------VVEEEGSVTEEIKEQ 4355

Query: 3017 STGLNFEEADMLDGSSSLIPEVYXXXXXXXXXXXXEGTEDGPNSLEGVKKASLHDAESEC 2838
               +N E  + ++ + S+  E+                        G+    + + ES+ 
Sbjct: 4356 EESVNEEVLEEVEETESIKEEIVEG---------------------GIATQEIIEEESDT 4394

Query: 2837 RELTELSEEVNRATSINDSENNTSKKEQGSIKNLEECIKEETIDTKLRNHLGDREIQNQE 2658
            +E+ E  EEV  +  + D+ + T +     +   +E ++E +   ++   L +++  N+E
Sbjct: 4395 KEVVE--EEVIDSEKLVDAGSVTGEVMPEEVSVTDEVVEEGSTTEEV---LEEQKSVNEE 4449

Query: 2657 VVASVGLTSEEQNFKPVSLSEKIECLDAENLNKHVDDSTTTHQLQENHAKAGSDFI-PEN 2481
            VV   GLT ++      S +E++   D   + K +++ T T ++ E       D +  E 
Sbjct: 4450 VVED-GLTIDDFVGLQGSTTEEVVEEDGSAIEKILEEETATEEIVEKQVSVTEDIVEKEG 4508

Query: 2480 KVHEKDTYSSKKEEQNVESFETSKE-PEIPQSWQERTIDGEKTLIEQSERESMKLERSDE 2304
             V+E+    +   E+ ++    ++E     +S  E  ID E  +  + E E    E+S  
Sbjct: 4509 SVNEEIIEEASVAEEIIQGGSFTEEIVGQEESATEEVIDEEGLISNEIEEEE---EKSVT 4565

Query: 2303 SDSIEVLEHTGVMDGSHEASTIKEEHSSKIIDTETVEDKKIAEDDAVHDQSTDPCRYETV 2124
             + IE +E   V D   E S  +E    +++D E + ++  A +D + +         +V
Sbjct: 4566 EEMIEEVEEVSVDDEVEEVSVAEEIVEEELVDDEILPEELSATEDVIEE-------VRSV 4618

Query: 2123 DRSLVNDEKE-QKSIELEPELEDDYYHTRAIEQGSNSKNQNXXXXXXXXXXXXEIIQDII 1947
               +V +E   ++ +E E    ++Y   +++        ++             +IQD+ 
Sbjct: 4619 TDEIVQEESVCEEILEQEVSASEEYVDDKSVTDDFVGHERS-------------VIQDV- 4664

Query: 1946 VEEHTANAAEEVIVQENSPKDDKVSKAPEGKVKESDIVFMEASDSVRXXXXXXXXXXXXE 1767
              E+T +  EE+   + S  ++ V K  +G V E  +   E   ++              
Sbjct: 4665 --ENTESVTEEIAEVDKSVIEEAVEK--QGSVTEEKV--QEGVSAIEEIEELESVTEEIA 4718

Query: 1766 GPKKSIDNFGTTE--ATLEEITKMETNDKPNYSSTESSLSEEQGMVEIPEKTESNNNETI 1593
               KS+      +  +  EEI + E  D      TE  L ++    ++ E+  S  +E+ 
Sbjct: 4719 EEDKSVIEEAVEKQGSVTEEIVEEEELD------TEEVLEDKSVTGDVVEQEGSGKDESE 4772

Query: 1592 FATPLTERLSLQDAETEDGELVDASSLASAKMIATQNQDVDDVKQKKSSNLTDNRTEDKF 1413
                 TE +    +  E+ +  +  S    +  AT+     ++   K    T++ T+D  
Sbjct: 4773 AKESFTEEVDELKSVKEEDQETEYISREIEEESATEQHSEQELSINKEVVETESLTKD-- 4830

Query: 1412 TAENSEAAAQEKSDIPVETSSIVLQSVDRDTETASVEEITARKPS-SVDILERNPQEPSK 1236
              E  ++  QE   I  ET S+  + V+ + +T   +E+   K S S +++E       +
Sbjct: 4831 -IEEEKSTTQE---ILEETQSVNEEIVEEERDT---DEVLKEKVSPSEEVIEEQASTTEE 4883

Query: 1235 LVSTKEELNKIGTQVMEAPLVEQTKREMNTQKEQDIKLEEDPATGIENSEQKISIPESDT 1056
             V  +   ++I  +V +    E  +RE +  +E    +EE   TG     + +    SDT
Sbjct: 4884 FVEERSSTDEI-VEVEDLFTEEVKEREGSVTEE---IVEEGSDTG-----EIVEEEGSDT 4934

Query: 1055 EKHISEQK-DGDVILERGDNTE-----------LNXXXXXXXXXXXXXSLKE-NQPESEE 915
            E+ + E   + +++ E G  TE           L               ++E  + ES  
Sbjct: 4935 EEILEEGSFNEEIVEEEGSITEEILQGSVTEEILQGSVTEEFVGQQGSVIEEIVETESAI 4994

Query: 914  SSLKDHETSDTCVNIKTDILEQEEDPIKKHDQ----NLEE-IKKEMKVDENVLEVQSTDH 750
                + E++   V+ +  + E  E+ +   D+    ++EE I+ E  V E +LE + +  
Sbjct: 4995 EERVEEESATEEVDERESVTEVVEEEVSSSDEVVEGSIEEVIENEGSVTEEILEHEVSAD 5054

Query: 749  SNEINEPCDTTENVTIAKKNLEATDP-CEELKKPTETVDHDQSQEVLPE---IEKTEVVN 582
             N + +     E V       E T+   EE+ + TE+V  ++  EV P    +++T+ V 
Sbjct: 5055 ENFVGQAVSVIEEV-------EGTESVTEEVVEETESVS-EEIVEVSPTENVVQQTDSVI 5106

Query: 581  DGEIIKDQDTVFAEDRTV----EQSIEEEKENDTLDKAGHKV----DVEDQSN--DMHHV 432
            + E+++ ++  F E+  +    +  +EE ++  T +  G       DVE+ S+  D   V
Sbjct: 5107 E-EVVEQKEGSFNEEIDIRELGDDGVEEREKISTEEVVGQDKSATGDVEEVSSTEDEEEV 5165

Query: 431  NHL--MKDTXXXXXXXXXXXXXEGDNIEKQSIEEEAAKCVGVLDYK--TRDKEVKDSDFT 264
            +    +++              + + +      EE +    V + K  T +  V++   T
Sbjct: 5166 SSTEGLEEVSSTEGLEEVSNTEDVEEVSSTEDVEEGSVAENVKETKSITEEVSVEEDIIT 5225

Query: 263  SNEGIANATYCKEKTEPDALT--CVKELNQSVNASCDTEASIEEVLEQEEV---SNTASE 99
                +      +   E + LT   V+E   +   S + +A  E+++ +EE+        E
Sbjct: 5226 DKVSVEQEVMAEASVEENILTEVPVEEEIMTEKLSVEDKALNEKIMSEEEIVIEDGNVHE 5285

Query: 98   DLGEVVTGTELDIPKMDNTT--DTCIKGGDI 12
             +   V+ TE +IP ++ TT  ++ +KG ++
Sbjct: 5286 VVPAEVSVTE-EIPGVEETTNNESHVKGENV 5315



 Score =  164 bits (415), Expect = 2e-37
 Identities = 345/1718 (20%), Positives = 696/1718 (40%), Gaps = 114/1718 (6%)
 Frame = -2

Query: 4889 EEKSINDGREKDKITAGLAIANADKGIGEPVIEEDVIQDQYTPTIGEEPTKECHEKEKVI 4710
            EE S ++   K++ +A   I   +  + E    E++++++ + T      +   ++  V 
Sbjct: 1135 EEGSASEKVVKEEGSASEKIVEEEGSVTEETASEEIVEEEGSVTEESSSEEIVEDEGSVT 1194

Query: 4709 EESKFDANKNIEEPTIEENDHSTTTILEKTI---RDAHENDKAVEDAIIED--VVMDYPK 4545
            EES  +     E   IEE+  ++  I+E  +   ++  E++ +V + ++E+   V D  +
Sbjct: 1195 EESSSEEIVEEEGSVIEES--ASEVIVEDEVSASKEIVEDEASVTEEVVEEEGAVSDEVQ 1252

Query: 4544 --KAITEETLKDGLEENKVIEGRNIVGADKDIDDPFIVEDDKCDVTATTRENSIKDGHEE 4371
              +++ +E +  G+ +  ++E    V  +   +D  ++E+   + T T      K   EE
Sbjct: 1253 VTESVEDEIINQGIVDEVIVEQEASVTDEIVKEDESVIEEIAVEETVTEVVEETKPMDEE 1312

Query: 4370 DKVIDEVKIVEADNDTSEHVREEEVADNSTTTIMEEPTNNDHEEDEIGLNATEGLEVVHA 4191
              ++D+  +VE  N   +   +EE+ D    +++E        ++EIG   +       A
Sbjct: 1313 --IVDQGSVVE--NVEEKKTMDEEIVDQG--SVVENVEEKKTMDEEIGDQGSV------A 1360

Query: 4190 DKDSEVPVIEENVVPYHSTTIVGDQTTNDGHEKDKGIEKLEIGGADQTTATIGEEPVEDD 4011
            +K  E  ++ E V+                 E++  I +  +  A  T      E VE  
Sbjct: 1361 EKVEEEELVTEEVI-----------------EREGSINEDIVKEASIT------EEVEQI 1397

Query: 4010 HGETKVAETLESASAHKDIGEHIIEEDVPDHSRTTISEEKVIERLEIIDANKNSGVAITD 3831
               T   E +ES +   +I E ++ ED+ +     +  E+++ +   ++  K    +IT+
Sbjct: 1398 EPVTGKVEKIESIT--DEIKEQLVPEDIKEEQ---LDFEEIVAQRASVNDEKVEVASITE 1452

Query: 3830 NNVVLDDSTRTTEQEPTKNGEEENKVIQKLEISSADKVIGD---PIIEDVPEHSTTTTG- 3663
                +++  ++  +E     EEE    +K+   S+ +V+ +    + E++ E  + + G 
Sbjct: 1453 E---VEEEEKSVSEEVL---EEEGSTTEKVVKGSSTEVVVEEQGSVTENLLEEESASQGI 1506

Query: 3662 ---------EEPVKEGH---KENKVIEQIQILGLDKEIGGPVVEENVAPNHSTTVIGEEA 3519
                     E+ VK+ +   KE  V EQ     L +E  G + E+N           EE 
Sbjct: 1507 VEKEEFVDEEDSVKDQNVFEKEGSVTEQ-----LVEEEKGLINEDNEK---------EEL 1552

Query: 3518 IHDGLEEDETIDGLQVDSTDKVNEEAITKEDLA------QEHSTT--TTQEKLIEDDHGE 3363
            I +  EE ++++  +++ TD   EE I ++ LA      +E S T    +E+ +  + GE
Sbjct: 1553 ITEMSEEIKSVNE-EIEETDLSTEEIIKQQGLATYEFVEEEKSLTDKLLEEESVTKEVGE 1611

Query: 3362 NKVSTELAIGEASRDAVKQITKDGSITE--LSTVSDIKEMTKENSQEEQM-------EAK 3210
             ++ST+  + E      + I ++ S++E  L   S  +E+ +E S  E +       E  
Sbjct: 1612 TELSTQEVVDEKVSVTEEVIEEEKSVSEEVLEEGSATEEVVEEGSCTEVVVEEGSCTEVV 1671

Query: 3209 KYEGEVKEL--------DLSTKTYEAPASAQKEETMTPSDEKEQHKNQHADSATDATTGK 3054
              EG   E+        ++  +   A     +E + T    +E    +        +   
Sbjct: 1672 VEEGSCTEIVVEKGSDTEIVVEEGSATEIVVEEGSATEVVVEEGSATEEVVEEGSVSEEM 1731

Query: 3053 TNEKGSEDLNDTSTGLNFEEADMLDGSSSLIPEVYXXXXXXXXXXXXEGTEDGPNSLEGV 2874
              E+GS        GL+ +      G    + E+Y               ++  N    +
Sbjct: 1732 LEEEGSATEEVVEEGLSSDNVQKSKGVIENVGEIY---------SVKTAKDESMNEKIPL 1782

Query: 2873 KKASLHDAESECRELTELSEEVNRATSINDSENNTSKKEQGSIKNL-EECIKEETIDTKL 2697
            +K+S  D ES   +    +  V    S  D  N  +  E+  I+ L  E I    I TK 
Sbjct: 1783 EKSSFVDDESFKGQGPTDNVSVEDVNS-EDIINEHTPLEETKIEELPTEYITTADIHTK- 1840

Query: 2696 RNHLGDREIQNQEVVASVGLTSEEQNFKPVSLSEKI---------ECLDAENLNKHVDDS 2544
                G+ E +   +   +    E+  F+   ++E I         + +   +L + V+  
Sbjct: 1841 ----GETETKYNLIYEKINEEVEKAKFQEEKITENIPVERESVTEDIVQEPSLAQEVEQK 1896

Query: 2543 TTTHQLQENHAKAGSDFIPENKVHEKDTYSSKKEEQNVESFETSKEPE-IPQSWQERTID 2367
             +     E    A    IPE  V E     +  E++ +++ E  +E E I +   E  + 
Sbjct: 1897 ESDTNEIEETKLANEKIIPEVSVTE-----NVVEKEGLDTEEVLEEDESITEEIVEEEVS 1951

Query: 2366 GEKTLIEQSERESMKLERSDESDSIEVLEHTGVMDGSHEASTIKEEHSSKIIDTETVEDK 2187
              + ++E+ E  S ++   +ES S E++E     + S     ++EE SS     E VE++
Sbjct: 1952 SSEEIVEEEESSSEEIVEEEESSSEEIVEE----EESSSEEIVEEEESS---SEEIVEEE 2004

Query: 2186 KIAEDDAVHD-QSTDPCRYE--TVDRSLVNDE----KEQKSI--ELEPELEDDYYHTRAI 2034
            + + ++ + +  ST+    E  +V   +V +E    +E K I    E  LE++ + T   
Sbjct: 2005 ESSSEEIIEEVSSTEEVLEEEGSVTEEIVEEEVSTTEEVKDIGSVSEEVLEEEGFGTEEF 2064

Query: 2033 --EQGSNSKN--QNXXXXXXXXXXXXEIIQDIIVEEHTANAAEEVIVQE--NSPKDDKVS 1872
              +QGS  +   +               +++I+ EE     A+E++ +E   + K D+V 
Sbjct: 2065 VGQQGSVIEEIVETESSTEKVLEDVGSNVEEIVQEE--GPVAQEIVHEEVSTTEKHDEVD 2122

Query: 1871 KAPEGKVKE-----SDIVFMEASDSVRXXXXXXXXXXXXEGPKKSIDNFGTTEATLEEIT 1707
            ++   ++ E     S+ + +E   +                 +K I+  G TE+  EEI 
Sbjct: 2123 RSTTEEIVEKVGSVSEEIIVEEVSASEEIVEEGSVTEEVVEEEKLINEVGETESVTEEIV 2182

Query: 1706 KMETNDKPNYSSTESSLSEE----QGMV-EIPEKTESNNNETIFATPLTERLSLQDAETE 1542
            + E +D       E S++EE    + +V EI     S   E +      E +  ++  TE
Sbjct: 2183 QKEVSDAEEVLGQEGSMNEEILEKESIVEEIVGPEGSVTEEIVDHGSFAEEVKEEELVTE 2242

Query: 1541 DGELVDASSLASAK--MIATQNQDVD-----DVKQKKSSNLTDNRTEDKFTAENSEAAAQ 1383
            +    + S     K     T+N+ ++     ++ ++K  N TD   +++           
Sbjct: 2243 EAVQYEGSVTEEIKEEESITENEAIEESAFAEIIEEKGPN-TDEIVKEEGLDTEEIVNEV 2301

Query: 1382 EKSDIPVETSSIVLQSVDRDTETASVEEITARKPSSVDILERNPQEPSKLV----STKEE 1215
              +D  +E   +V + +  +  + + + +   + ++ D++E       K+     ST E+
Sbjct: 2302 SVTDEVIEEEKLVNEQIVGEERSVTEKPVEVERSATEDLVEEEASVTEKVSVHEGSTTEQ 2361

Query: 1214 L--NKIGTQVMEAPLVEQTKREMNTQKEQDIKLEEDPATGIENSEQKISIPESDTEKHIS 1041
            +    +  +++E   V    + +  +   D  +EE+ +   E  E++ S+PE   E+ +S
Sbjct: 2362 ILDESVAEEIVEEE-VSVDDKIIEEEVSVDEVVEEEGSVIEEIVEEEESVPEEILEEELS 2420

Query: 1040 EQKDGDVILERGDNTELNXXXXXXXXXXXXXSLKENQPE--SEESSLKDHETSDTCVNIK 867
                       G    L              S+ E   E    E S+ +    D   N K
Sbjct: 2421 -----------GSEEVLEDEWVTDAFMGQEGSVIEEIEEIVDGEGSITEEIVEDGSANEK 2469

Query: 866  TDILEQE----EDPIKKHDQNLEEIKKEMKVDENVLEV----QSTDHSNEINEPCDTTEN 711
              I+E+E    E+ + K    +EEI +E  V E V +     + ++ S+ I E  +  E 
Sbjct: 2470 --IVEEEPSRVEEVLGKEGFVIEEIIEEGSVIEQVEDTKTVSEKSEESSAIEEVKEVKEE 2527

Query: 710  VTIAKKNLEATDP-CEELKKPTETVDHDQSQEVLPE---IEKTEVVNDGEIIKD-QDTVF 546
             +I++K +E  +   EE+ +  E+      ++V P    +E+T+ V +  I ++  +T  
Sbjct: 2528 ESISEKIVEKEESVTEEIVRQEESTTEKIVKDVSPTEDFVEQTDSVTEKVIEQEGSNTEV 2587

Query: 545  AEDRTVEQSIEEEKENDTLDKAGHKVDVEDQSNDMHHVNHLMKDTXXXXXXXXXXXXXEG 366
            AED   ++S  +E E +         DV   +   +    + K+               G
Sbjct: 2588 AEDVEEKESASDEHEQE---------DVSVNAQVTYEKKSVTKEIVDEVSRTEEIVEENG 2638

Query: 365  DNIEKQSIEEEAAKCVGVLDYKTRDKEVKDSDFTSNEGIANATYCKEKTEPDALT--CVK 192
               E   ++E  +    +++  T  +EV +    + E + + +  +E  E  ++T   V+
Sbjct: 2639 SVTE--GVDETGSVTEEIIEEATVTEEVVEDGSVTEEVVEDGSVIQEVVEDGSVTEEIVQ 2696

Query: 191  ELNQSVNASCDTEASIEEVLEQEEVSNTASEDLGEVVT 78
            E         + E S+ E +E EEVS +   D  E VT
Sbjct: 2697 ENGSVTEEIVEEEGSVNEEVE-EEVSVSGEVDETEYVT 2733



 Score =  159 bits (402), Expect = 7e-36
 Identities = 380/1881 (20%), Positives = 744/1881 (39%), Gaps = 263/1881 (13%)
 Frame = -2

Query: 4889 EEKSINDGREKDKITAGLAIANADKGIGEPVIEEDVIQDQYTPTIGEEPTKECHEKEKVI 4710
            E++S +D  E++ ++    +    K + + +++E         +  EE  +E     + +
Sbjct: 2593 EKESASDEHEQEDVSVNAQVTYEKKSVTKEIVDE--------VSRTEEIVEENGSVTEGV 2644

Query: 4709 EESKFDANKNIEEPTIEENDHSTTTILEKTIRDAHENDKAVED-AIIEDVVMDYPKKAIT 4533
            +E+     + IEE T+ E      ++ E+ + D     + VED ++ E++V +    ++T
Sbjct: 2645 DETGSVTEEIIEEATVTEEVVEDGSVTEEVVEDGSVIQEVVEDGSVTEEIVQE--NGSVT 2702

Query: 4532 EETLKDGLEENKVIEGRNIVGADKDIDDPF-------------IVEDD-----KCDVTAT 4407
            EE +++    N+ +E    V  + D  +               IVE++     + D T  
Sbjct: 2703 EEIVEEEGSVNEEVEEEVSVSGEVDETEYVTEEVEEEGSVVEEIVEEEGSVSGEVDETEY 2762

Query: 4406 TRENSIKDGHEEDKVIDEVKIVEADNDTSEHVREEEVADNSTTT-IMEEPTNNDHEEDEI 4230
              E   ++G   +++++E   V  + D +E+V EE   + S    I+EE  +   E DE 
Sbjct: 2763 VTEEVEEEGSVVEEIVEEEGSVSGEVDETEYVTEEVEEEGSVVEEIVEEEGSVSGEVDET 2822

Query: 4229 GLNATEGLE----VVHADKDSEVPVIEENVVPYHSTTIVGDQT-------------TNDG 4101
                TE +E    VV    + E  V+EE V    S + V D+T             T + 
Sbjct: 2823 EY-VTEEVEEEGSVVEEIVEEEGSVVEEIVEEEGSVSEVVDETELVNDEIVEQAPFTEEV 2881

Query: 4100 HEK----DKGIEKLEIGGADQTTATIGEEPVEDDHGET-----KVAETLESASAHKDIGE 3948
             E+    D+ IE   +  A + + +I E   +++  E      KV ET   A   + + +
Sbjct: 2882 EEQVSVNDEIIEDASVAEAVEESESITESVSQEEETEKGFVIEKVEET--GAVTEEIVQD 2939

Query: 3947 HIIEEDVPDHSRTTISE--------EKVIERLEIIDANKNSGVAITDNNVVLDDSTRTTE 3792
             +I E++ + S +   E        E+++E  E +          T   +V ++ + T E
Sbjct: 2940 GLITEEILEESESVNGEIINKESDAEEILET-EFLTEEVVGQAGSTSEEIVEEEGSVTKE 2998

Query: 3791 QEPTKNGEEE----NKVIQKL--EISSADKVI--GDPIIEDVPEHSTTT-------TGEE 3657
             E  ++  EE      V ++L  E S  ++V+  G  I +++ E  + T       T  E
Sbjct: 2999 VEEKESVTEELVDEGSVTEELVDEGSVTEEVVEQGGSIAQEIVEEESATEEIIRDETNVE 3058

Query: 3656 PV--KEGHKENKVIEQIQILGLDKEIG--GPVVEENVAPNHSTT-------------VIG 3528
             V  KEG    ++++     G +  +G  G V+EE V    STT              + 
Sbjct: 3059 EVLEKEGSATEEIVQDGS--GTNDFVGKQGSVIEEVVEEEISTTEEKLKEEASAIEEFVE 3116

Query: 3527 EEAIHDGLEED----ETIDGLQVDSTDKV-------------NEEAITKEDLAQEHSTTT 3399
            EE+I + + E+    E + G Q   T+++              EE++T+E +  E S T 
Sbjct: 3117 EESIREDVLEESLVTENVVGQQESVTEEIVDGEGSFTEDIVEEEESVTEEIVVDEESVTK 3176

Query: 3398 --------TQEKLIEDDHGENKVSTELAIGEAS--------RDAVKQITKDGSITELSTV 3267
                      E+++ED   E   + E+   E S        R  ++++    ++ E    
Sbjct: 3177 EIVEDEELVTEEIVED---EGSFTEEIVEDEGSFTEEVIEERSLIEEVEDTETVAEKEEG 3233

Query: 3266 SDIKEMTKENSQEEQM---------EAKKYEGEVKELDLSTKTYEAPASAQK-------- 3138
            S IKE+  E S  E++         E ++ E   +E++      E   SA +        
Sbjct: 3234 SVIKEIIDEKSLTEKIVEEEKSVTEEVEEKESVKEEVEEQRLVVEEEGSATEGIVEDRLA 3293

Query: 3137 ---------------EETMTPSDEKEQHKN---QHADSATDATTGKTNEKGSEDLNDTST 3012
                           E+ +   +  EQ  +   +  D     T     E+GS +      
Sbjct: 3294 TEGIVDDILVTEEIVEDGLATDEFVEQQGSIIEEVLDDEGSVTEEIVEEEGSPNEEIVEG 3353

Query: 3011 GLNFEEADMLDGSSSLIPEVYXXXXXXXXXXXXEGTEDGPNSLEGVKKASLHDAESECRE 2832
                EE D ++  S  I E               G+       EG++   + D +S   E
Sbjct: 3354 VSVIEEDDNIEPVSEEIVE---------------GSVTEEMIKEGLENEVILDEDSITEE 3398

Query: 2831 LTE----LSEEV-----NRATSINDSENNTSKK--EQGSIKNLEECIKEETIDTKLRNHL 2685
              E    +SEE+     +    I D E +TS+   E+GS    EE I+EE+   ++   +
Sbjct: 3399 ALEKEGSVSEEIVEEMGSLTEEIVDEERSTSEDMIEEGSAS--EEIIQEESQVEEVVEEV 3456

Query: 2684 G-------DREIQNQEVVASVGLTSEE---QNFKPVSLSEKIECLDAE-NLNKHVDDS-- 2544
                    + E+  +EVV  +   +EE      +  S++E+I   + E ++N+ + +   
Sbjct: 3457 SVIDEIVEEDELDTKEVVEEIEFNTEEVVEHKEEEGSVAEEIVQEEKEGSVNEEIIEEVG 3516

Query: 2543 TTTHQLQENHAKAGSDFIPENKV---HEKDTYSSKK-EEQNVESFET-SKEPEIPQSWQE 2379
            + T ++ E       + + E  V    E++ +  K+ EE+ +++ E   +E  + +  +E
Sbjct: 3517 SITEEMVEQDVSDNEEIVEERSVIEEAEENVWIEKEVEEEGLDNEEVIDEEDSVSEQAEE 3576

Query: 2378 RTIDGEKTLIEQSERESMKLER-------SDESDSIE------------VLEHTGVMDGS 2256
                 E+ L E S+ E +K+E        ++E+ S+             V+E T  +   
Sbjct: 3577 EVYINEEILKESSDVEDVKVENELMNEEVNEETQSVAENNEEDKELDNYVVEETESVTEE 3636

Query: 2255 ---HEASTIKEEHSSKIIDTETVEDKKIAED----------DAVHDQSTDPCRYETVDRS 2115
                E    KE    + I  E VED    +D          + V +  +D    E V+ +
Sbjct: 3637 VVVDEVPNSKEVQEIESIIEEIVEDGLTTDDLVGQQGSVIEEVVEEVGSDS--EEIVEEA 3694

Query: 2114 LVNDEKEQKSIELEPELEDDYYHTRAIEQGSNSKN---QNXXXXXXXXXXXXEIIQDIIV 1944
             + +E E+K    E  L ++      + +GS ++    +              + Q+I+ 
Sbjct: 3695 SITEEVEKKESVTEDILVEESVTGDILVEGSVTEEVVGEEKLVSEEIVTEEGSVAQEIVE 3754

Query: 1943 EEHTAN-------AAEEVIVQENSPKDDKVSKAPEGKVKESDIVFMEASDSV---RXXXX 1794
            E+  A        +  E +V+E  P D+++ +  EG V E  I      + V   +    
Sbjct: 3755 EDAPATEEIDEIESVTEEVVEEEGPVDEEIVQE-EGSVTEEIIQGESKVEEVVEEQGSEN 3813

Query: 1793 XXXXXXXXEGPKKSIDNFGTTEATLEEITKMETNDKPNYSSTESSLSEEQGMVE-IPEKT 1617
                       ++ + N   TE  LE+++  +   +   S TE  + E++ + E +  + 
Sbjct: 3814 EEIFVEEVSASQEIVQNESGTEEILEKVSASQEIVQDG-SVTEQIIEEQKPVTEEVVNEE 3872

Query: 1616 ESNNNETIFATPLTERLSLQDAETEDGELVDASSLASAKMIATQNQDVDDVKQKK--SSN 1443
            ES  +E I      E++  Q +  E  E+V+     + +++  +    +D+ Q+   +  
Sbjct: 3873 ESITHEIIQEESHVEKVVQQGSVAE--EVVENPVSVTEEIVEKEGSVTEDIGQEGYVAEE 3930

Query: 1442 LTDNRTEDKFTAENSEAAAQEKSDIPVETSSIVLQSVDRDT----ETASVEEITARKPS- 1278
            + +    D       E+ A+E  +   +   I ++ +        E +  EE+   + S 
Sbjct: 3931 IVEEEEFDNEEILEEESVAEEFVEEGFDNEEIFVEQISDSEIVKEENSVNEEVLEEEGSY 3990

Query: 1277 SVDILERNPQEPSKLVSTKEELNKIGTQVME--APLVEQTKREMNTQKEQDIKLEEDPAT 1104
            + +ILE   +E S      EE      +++E      E+   E  +  E+   LEE+ + 
Sbjct: 3991 TEEILE---EEGSYTEEILEEEGSFTEEILEEEGSYNEEILEEEGSYNEEI--LEEEGSY 4045

Query: 1103 GIENSEQKISIPE-------SDTEKHISEQKDGDVILERGDNTELNXXXXXXXXXXXXXS 945
              E  E++ S  E       S T+  + +  D + I+E G  T+                
Sbjct: 4046 NEEILEEEGSYNEEILEEEGSATDYFVGQGSDNEEIIEEGSATDYFVGQG---------- 4095

Query: 944  LKENQPESEESSLKDHETSDTCVNIKTDILEQEEDPIKKHDQN-------------LEEI 804
              +N+   EE S  D+       +I  ++LE+E    +K  +N              E +
Sbjct: 4096 -SDNEEIIEEGSATDYFVGQG--SIIEEVLEEEGLDTEKVFENEGSATEFEETESFTEVV 4152

Query: 803  KKEMKVDENVLEVQSTDHSNEINEPCDTTENVTIAKKNLEATDPCEELKKPTETVDHDQS 624
            ++   V+EN+LE  S +   +I    +  +   + ++  E     EE+K+     +  + 
Sbjct: 4153 EETESVNENILEETSINEVQKIESITEDIKEQLVPEEIKEEQLDSEEIKEEQLDSEEIKE 4212

Query: 623  QEVLPEIEKTEVVNDGEIIKDQDTVFAEDRTVEQSIEEEKENDTLDKAGHKVDVEDQSND 444
            ++++PE  K E ++  EI ++Q  + +E+   EQ   EE + + LD      +++++   
Sbjct: 4213 EQLVPEEIKEEQLDSEEIKEEQ--LDSEEIKEEQLDSEEIKEEQLDSE----EIKEEQLV 4266

Query: 443  MHHVNHLMKDTXXXXXXXXXXXXXEGDNIEKQSIEEEAAKCVGVLDYKTRDKEVKDSDFT 264
               +     D+             + + ++ + I+EE      + + +   +E+K+    
Sbjct: 4267 PEEIKEEQLDSEEIKEEQLVPEEIKEEQLDSEEIKEEQLDSEEIKEEQLDSEEIKEEQLD 4326

Query: 263  SNE-----GIANATYCKEKTEPDALTCVKELNQSVNASCDTEASIEEVLEQEEVSNTASE 99
            S E     G  N    +E  E      +KE  +SVN         EEVLE+ E + +  E
Sbjct: 4327 SEEIKEQKGSVNEEVVEE--EGSVTEEIKEQEESVN---------EEVLEEVEETESIKE 4375

Query: 98   DLGEVVTGTELDIPKMDNTTD 36
            ++ E    T+  I +  +T +
Sbjct: 4376 EIVEGGIATQEIIEEESDTKE 4396



 Score =  151 bits (381), Expect = 2e-33
 Identities = 353/1762 (20%), Positives = 699/1762 (39%), Gaps = 199/1762 (11%)
 Frame = -2

Query: 4805 EPVIEEDVIQDQYTPTIGEEPTKECHEKEKVIEESKFDANKNIEEPT-----IEENDHST 4641
            E  ++E+++Q++ + T  EE  +   + E+V+EE   +  +   E       I +N+  T
Sbjct: 3777 EGPVDEEIVQEEGSVT--EEIIQGESKVEEVVEEQGSENEEIFVEEVSASQEIVQNESGT 3834

Query: 4640 TTILEKT------IRDAHENDKAVEDA--IIEDVVMDYPKKAITEETLKDGLEENKVIEG 4485
              ILEK       ++D    ++ +E+   + E+VV +  +++IT E +++     KV++ 
Sbjct: 3835 EEILEKVSASQEIVQDGSVTEQIIEEQKPVTEEVVNE--EESITHEIIQEESHVEKVVQQ 3892

Query: 4484 RNIVGADKDIDDPFIVEDDKCDVTATTRENSIKDGHEEDKVIDEVK-----IVEADNDTS 4320
             ++  A++ +++P  V ++  +   +  E+  ++G+  +++++E +     I+E ++   
Sbjct: 3893 GSV--AEEVVENPVSVTEEIVEKEGSVTEDIGQEGYVAEEIVEEEEFDNEEILEEESVAE 3950

Query: 4319 EHVRE---------EEVADNSTTTIMEEPTNNDHEEDEIGLNATEGLEVVHADKDSEVPV 4167
            E V E         E+++D+    + EE + N+   +E G    E LE    ++ S    
Sbjct: 3951 EFVEEGFDNEEIFVEQISDSEI--VKEENSVNEEVLEEEGSYTEEILE----EEGSYTEE 4004

Query: 4166 IEENVVPYHSTTIVGDQTTNDGHEKDKGIEKLEIGGADQTTATIGEEPVEDDHGETKVAE 3987
            I E    +    +  + + N+   +++G    EI    +   +  EE +E++    +   
Sbjct: 4005 ILEEEGSFTEEILEEEGSYNEEILEEEGSYNEEIL---EEEGSYNEEILEEEGSYNEEIL 4061

Query: 3986 TLESASAHKDIGEHIIEEDVPDHSRTT-------ISEEKVIERLEIIDANKNSGVAIT-- 3834
              E ++    +G+    E++ +    T          E++IE     D     G  I   
Sbjct: 4062 EEEGSATDYFVGQGSDNEEIIEEGSATDYFVGQGSDNEEIIEEGSATDYFVGQGSIIEEV 4121

Query: 3833 ------DNNVVLDDSTRTTEQEPTKNGEE--------ENKVIQKLEISSADKVIGDPIIE 3696
                  D   V ++    TE E T++  E           ++++  I+   K+  + I E
Sbjct: 4122 LEEEGLDTEKVFENEGSATEFEETESFTEVVEETESVNENILEETSINEVQKI--ESITE 4179

Query: 3695 DVPEHSTTTTGEEPVKEGHKENKVIEQIQILGLDKEIGGPVVEENVAPNH-STTVIGEEA 3519
            D+ E        E +KE   +++ I++ Q   LD E    + EE + P       +  E 
Sbjct: 4180 DIKEQLVP----EEIKEEQLDSEEIKEEQ---LDSE---EIKEEQLVPEEIKEEQLDSEE 4229

Query: 3518 IHDGLEEDETIDGLQVDS---------TDKVNEEAITKEDLAQEH--STTTTQEKLIEDD 3372
            I +   + E I   Q+DS         ++++ EE +  E++ +E   S    +E+L+ ++
Sbjct: 4230 IKEEQLDSEEIKEEQLDSEEIKEEQLDSEEIKEEQLVPEEIKEEQLDSEEIKEEQLVPEE 4289

Query: 3371 HGENKVSTELA-------------------IGEASRDAVKQITKDGSITELSTVSDIKEM 3249
              E ++ +E                     I E   D+ +   + GS+ E   V +   +
Sbjct: 4290 IKEEQLDSEEIKEEQLDSEEIKEEQLDSEEIKEEQLDSEEIKEQKGSVNE-EVVEEEGSV 4348

Query: 3248 TKENSQEEQMEAKKYEGEVKELDLSTKTYEAPASAQKEETMTPSDEKEQHKNQHADSATD 3069
            T+E  ++E+   ++   EV+E +   +       A +E     SD KE  + +  DS   
Sbjct: 4349 TEEIKEQEESVNEEVLEEVEETESIKEEIVEGGIATQEIIEEESDTKEVVEEEVIDSEKL 4408

Query: 3068 ATTGK-TNEKGSEDLNDTST----GLNFEEADMLDGSSSLIPEVYXXXXXXXXXXXXEGT 2904
               G  T E   E+++ T      G   EE  +L+   S+  EV             +G+
Sbjct: 4409 VDAGSVTGEVMPEEVSVTDEVVEEGSTTEE--VLEEQKSVNEEVVEDGLTIDDFVGLQGS 4466

Query: 2903 -------EDGPNSLEGVKKASLHDAESECRELTELSEEVNRATSINDS--ENNTSKKE-- 2757
                   EDG +++E + +      E   ++++   + V +  S+N+   E  +  +E  
Sbjct: 4467 TTEEVVEEDG-SAIEKILEEETATEEIVEKQVSVTEDIVEKEGSVNEEIIEEASVAEEII 4525

Query: 2756 QGS-----IKNLEECIKEETIDTK--LRNHLGDREIQN--QEVVASVGLTSEEQNFKPVS 2604
            QG      I   EE   EE ID +  + N + + E ++  +E++  V   S +   + VS
Sbjct: 4526 QGGSFTEEIVGQEESATEEVIDEEGLISNEIEEEEEKSVTEEMIEEVEEVSVDDEVEEVS 4585

Query: 2603 LSEKI---ECLDAENLNKH------------------VDDSTTTHQLQENHAKAGSDFIP 2487
            ++E+I   E +D E L +                   V + +   ++ E    A  +++ 
Sbjct: 4586 VAEEIVEEELVDDEILPEELSATEDVIEEVRSVTDEIVQEESVCEEILEQEVSASEEYVD 4645

Query: 2486 ENKVHEKDTYSSKKEEQNVESFETSKEP--EIPQSWQERTIDGEKTLIEQSERESMK-LE 2316
            +  V +      +   Q+VE+ E+  E   E+ +S  E  ++ + ++ E+  +E +  +E
Sbjct: 4646 DKSVTDDFVGHERSVIQDVENTESVTEEIAEVDKSVIEEAVEKQGSVTEEKVQEGVSAIE 4705

Query: 2315 RSDESDSI---------EVLEHTGVMDGSHEASTIKEEHSSKIIDTETVEDKKIAEDDAV 2163
              +E +S+          V+E      GS     ++EE     +DTE V + K    D V
Sbjct: 4706 EIEELESVTEEIAEEDKSVIEEAVEKQGSVTEEIVEEEE----LDTEEVLEDKSVTGDVV 4761

Query: 2162 HDQSTDPCRYETVDRSLVNDEKEQKSIELEPELEDDYYHTRAIEQGSNSK--NQNXXXXX 1989
              + +     E  + S   +  E KS++ E +  +  Y +R IE+ S ++  ++      
Sbjct: 4762 EQEGSGKDESEAKE-SFTEEVDELKSVKEEDQ--ETEYISREIEEESATEQHSEQELSIN 4818

Query: 1988 XXXXXXXEIIQDIIVEEHTAN-------AAEEVIVQENSPKDD--KVSKAPEGKVKESDI 1836
                    + +DI  E+ T         +  E IV+E    D+  K   +P  +V E   
Sbjct: 4819 KEVVETESLTKDIEEEKSTTQEILEETQSVNEEIVEEERDTDEVLKEKVSPSEEVIEEQA 4878

Query: 1835 VFMEASDSVRXXXXXXXXXXXXEGPKKSIDNFGTTEATLEEITKMETNDKPNYSSTESSL 1656
               E     R               +        TE  +EE +      +   S TE  L
Sbjct: 4879 STTEEFVEERSSTDEIVEVEDLFTEEVKEREGSVTEEIVEEGSDTGEIVEEEGSDTEEIL 4938

Query: 1655 SEEQGMVEIPEKTESNNNETIFATPLTERLSLQDAETEDGELVDASSLASAKMIATQNQD 1476
             E     EI E+ E +  E I    +TE + LQ + TE  E V        +++ T++  
Sbjct: 4939 EEGSFNEEIVEE-EGSITEEILQGSVTEEI-LQGSVTE--EFVGQQGSVIEEIVETESAI 4994

Query: 1475 VDDVKQKKSSNLTDNRTEDKFTAENSEAAAQEKSDIPVETSSIVLQSVDRDTETASVEEI 1296
             + V+++ ++   D R       E   +++ E  +  +E    V+++    TE     E+
Sbjct: 4995 EERVEEESATEEVDERESVTEVVEEEVSSSDEVVEGSIEE---VIENEGSVTEEILEHEV 5051

Query: 1295 TARKP---SSVDILERNPQEPSKLVSTKEELNKIGTQVMEAP----LVEQTK---REMNT 1146
            +A +     +V ++E      S      EE   +  +++E      +V+QT     E+  
Sbjct: 5052 SADENFVGQAVSVIEEVEGTESVTEEVVEETESVSEEIVEVSPTENVVQQTDSVIEEVVE 5111

Query: 1145 QKE----QDIKLEEDPATGIENSEQKISIPESDTEKHISEQKDGDVILERGDNTE----- 993
            QKE    ++I + E    G+E  E KIS     TE+ + + K     +E   +TE     
Sbjct: 5112 QKEGSFNEEIDIRELGDDGVEERE-KIS-----TEEVVGQDKSATGDVEEVSSTEDEEEV 5165

Query: 992  -LNXXXXXXXXXXXXXSLKENQPESEESSLKDHETSDTCVNIK-----TDILEQEEDPIK 831
                             +   +   E SS +D E      N+K     T+ +  EED I 
Sbjct: 5166 SSTEGLEEVSSTEGLEEVSNTEDVEEVSSTEDVEEGSVAENVKETKSITEEVSVEEDIIT 5225

Query: 830  KH---------DQNLEE-IKKEMKVDENVLEVQSTDHSNEINEPCDTTENVTIAKKNLEA 681
                       + ++EE I  E+ V+E ++  + +     +NE   + E + I   N+  
Sbjct: 5226 DKVSVEQEVMAEASVEENILTEVPVEEEIMTEKLSVEDKALNEKIMSEEEIVIEDGNVHE 5285

Query: 680  TDPCE--------ELKKPTETVDHDQSQEVLPEIEKTEVVNDGEIIKDQDTVFAEDRTVE 525
              P E         +++ T    H + + V+ E+    VV+D  +  + +  F +D ++E
Sbjct: 5286 VVPAEVSVTEEIPGVEETTNNESHVKGENVVNEV----VVDDNSV--NDEIQFDDDSSIE 5339

Query: 524  QSIEEEKENDTLDKAGHKVDVEDQSNDMHHVNHLMKDTXXXXXXXXXXXXXEG----DNI 357
                + K  D   K  +     ++     +++   K                G    +  
Sbjct: 5340 IYTVDSK--DVFHKEENYDSFREEVRSDENIHIFRKKNENFVKKIENEKSSVGHVPTEYT 5397

Query: 356  EKQSIEEEAAKCVGVLDYKTRD--KEVKDSDFTSNEGIANATYCKEKTEPDALTCVKELN 183
             K++I EE    +   +  T +  KEVK  + T  E     T  KE         ++E  
Sbjct: 5398 SKENIAEEVPSHIMFKENVTEEVPKEVKYEENTVEEVFEEVT-SKE-------NIIEEAP 5449

Query: 182  QSVNASCDTEASIEEVLEQEEV 117
              +N+  +    + EV+  EE+
Sbjct: 5450 GDINSEENIIEEVPEVVTSEEI 5471



 Score =  114 bits (284), Expect = 3e-22
 Identities = 252/1244 (20%), Positives = 496/1244 (39%), Gaps = 71/1244 (5%)
 Frame = -2

Query: 3527 EEAIHDGLEEDETIDGLQVDSTDKVNEEAITKEDLAQEHSTTTTQEKLIEDDHGENKVST 3348
            EE + +   E+   +   ++  ++  +E   ++ + +   T  T+E   E+   E +++ 
Sbjct: 584  EEKMKELESEEFPKEKYNIEDMEETEKENEIEKIMDENKETEQTEEGNTEEFVQEKELNQ 643

Query: 3347 ELAIGEASRDAVKQITKDGSITELSTV---SDIKEMTKENSQEEQMEAKKYEGEVKELDL 3177
            E    E   D +K+     ++ E  +V   S I+E+  EN+  +  E  + E  + E+ L
Sbjct: 644  ETLENEIIVDHIKEEEDTRNVKEQESVLEESPIEELPVENNIGKINEEVE-EFILNEIPL 702

Query: 3176 STKTYEAPASAQKEETMTPSDEKEQHKNQHADSATDATTGK---TNEKGSEDLNDTSTGL 3006
              +  +     + EE +      ++H +    + T+  T K    NE+   +    S  +
Sbjct: 703  EEQVPKELPQEEIEEIVVEELPIDEHLSSEETTVTEEDTFKGQLINEEKPVEEKSVSEEI 762

Query: 3005 NFEEADMLDGSSSLIPEVYXXXXXXXXXXXXEGTEDGPNSLEGVKKASLHDAESECRELT 2826
              EE  +                          +E+ P   + V +    + +S   E+ 
Sbjct: 763  PVEEKSV--------------------------SEEIPVEEKSVSEEIPVEEKSVSEEIP 796

Query: 2825 ELSEEVNRATSINDSENNTSKKEQGSIKNLEECI--KEETIDTKL-RNHLGDREIQNQEV 2655
               EE N +  I   E N S++     KN+ E I  +EE +  ++    +   ++   E 
Sbjct: 797  V--EEKNVSEEIPVEEKNVSEEIPVEEKNVSEEIPVEEENVSEEIPEGGIAIEDVPVDEE 854

Query: 2654 VASVGLTSEEQNFKPVSLSEKIECLDAENLNKHVDDSTTTHQLQENHAKAGSDFIPENKV 2475
              +  +T +E+ +    L  +IE ++ E     V+D T T Q+   H +   + I E   
Sbjct: 855  TVTEEITVDEKIYD--KLPNEIETVNEE---MPVEDETLTEQISSEHERVPEEIIEEKPF 909

Query: 2474 HEKDTYSSKKEEQNVESFETSKEPEIPQSWQERTIDGEKTLIEQSERESM---KLERSDE 2304
             E +   S  +E   E   T   PE  Q   E+  + E+ +  +   E +   K++  DE
Sbjct: 910  TEGEETESLTDEIVEEGVVTDDIPE-EQIITEKVQEEEEFVTGELSEEDIINEKVQEEDE 968

Query: 2303 SDSIEVLEHTGVMDGSHEASTIKEEHSSKIID----TETVEDKKIAEDDAVHDQSTDPCR 2136
            S + E+ E   + +   E    +E    +I+     T+ VE K++  DD V D+      
Sbjct: 969  SVTEELPEEDIINEKVQEE---EESAYQEIVQDGSVTKDVEYKELVNDD-VRDKENFVIE 1024

Query: 2135 YETVDRSLVND----EKEQKSIELEPELEDDYYHTRAIEQGSNSKNQNXXXXXXXXXXXX 1968
             +     L+N+    E+E  + EL P  E+  +     E  S +K               
Sbjct: 1025 EDPFKGQLINEGLPVEEEFVTKEL-PVKEESVFEELTEEDQSVTK--------------- 1068

Query: 1967 EIIQDIIVEEHTA--------NAAEEVIVQENSPKDDKVSKAP-EGKVKESDIVFMEASD 1815
                +I VEEH+         +  +E++ +E S  ++   +    G+V E++ V  E  +
Sbjct: 1069 ----EIPVEEHSVFKEVDEIESVTDEIVEEEGSVNEEVEEEVSVSGEVDETEYVTEEVEE 1124

Query: 1814 SVRXXXXXXXXXXXXEGPKKSIDNFGTTEATLEEITKMETNDKPNYSSTESSLSEEQGMV 1635
            +                 ++ +   G+     E++ K E +        E S++EE    
Sbjct: 1125 TELVN-------------EEVLKEEGSAS---EKVVKEEGSASEKIVEEEGSVTEETASE 1168

Query: 1634 EIPEK----TESNNNETIFATP--LTERLSLQDAETEDGELVD--ASSLASAKMIATQNQ 1479
            EI E+    TE +++E I      +TE  S ++   E+G +++  AS +     ++   +
Sbjct: 1169 EIVEEEGSVTEESSSEEIVEDEGSVTEESSSEEIVEEEGSVIEESASEVIVEDEVSASKE 1228

Query: 1478 DVDDVKQKKSSNLTDNRTEDKFTAENSEAAAQEKSDIPVETSSIVLQSVDRDTETASVEE 1299
             V+D      +++T+   E++  A + E    E  +  +    IV   V  + E +  +E
Sbjct: 1229 IVED-----EASVTEEVVEEE-GAVSDEVQVTESVEDEIINQGIV-DEVIVEQEASVTDE 1281

Query: 1298 ITARKPSSVDILERNPQEPSKLVSTKEELNKIGTQVMEAPLVEQTKREMNTQKEQDIKLE 1119
            I     S   ++E    E + +    EE   +  ++++   V +   E  T  E+ +   
Sbjct: 1282 IVKEDES---VIEEIAVEET-VTEVVEETKPMDEEIVDQGSVVENVEEKKTMDEEIV--- 1334

Query: 1118 EDPATGIENSEQKISIPE------SDTEKHISEQKDGDVILERGDNTELNXXXXXXXXXX 957
             D  + +EN E+K ++ E      S  EK   E+   + ++ER  +              
Sbjct: 1335 -DQGSVVENVEEKKTMDEEIGDQGSVAEKVEEEELVTEEVIEREGSI------------- 1380

Query: 956  XXXSLKENQPESEESSLKDHETSDTCVNIKTDILEQEEDPIKKHDQNLEEIKKEMKVDEN 777
                   N+   +E+S+ +       V  K + +E   D IK  +Q + E  KE ++D  
Sbjct: 1381 -------NEDIVKEASITEEVEQIEPVTGKVEKIESITDEIK--EQLVPEDIKEEQLDFE 1431

Query: 776  VLEVQSTDHSNEINEPCDTTENVTIAKKNLEATDPCEELKKPTETVDHDQSQEVLPE--- 606
             +  Q    ++E  E    TE V   +K++ + +  EE    TE V    S EV+ E   
Sbjct: 1432 EIVAQRASVNDEKVEVASITEEVEEEEKSV-SEEVLEEEGSTTEKVVKGSSTEVVVEEQG 1490

Query: 605  ----------------IEKTEVVNDGEIIKDQDTVFAEDRTVEQSIEEEKENDTLDKAGH 474
                            +EK E V++ + +KDQ+    E    EQ +EEEK     D    
Sbjct: 1491 SVTENLLEEESASQGIVEKEEFVDEEDSVKDQNVFEKEGSVTEQLVEEEKGLINEDNEKE 1550

Query: 473  KVDVEDQSNDMHHVNHLMKDTXXXXXXXXXXXXXEGDNIEKQS-------IEEEAAKCVG 315
            ++ + + S ++  VN  +++T               + I KQ        +EEE +    
Sbjct: 1551 EL-ITEMSEEIKSVNEEIEETDLST-----------EEIIKQQGLATYEFVEEEKSLTDK 1598

Query: 314  VLDYKTRDKEVKDSDFTSNEGIANATYCKEKTEPDALTCVKELNQSVNASCDT--EASIE 141
            +L+ ++  KEV +++ ++ E +       E+   +  +  +E+ +  +A+ +   E S  
Sbjct: 1599 LLEEESVTKEVGETELSTQEVVDEKVSVTEEVIEEEKSVSEEVLEEGSATEEVVEEGSCT 1658

Query: 140  EVLEQEEVSNTASEDLGEVVTGTELDIPKMDNTTDTCIKGGDIE 9
            EV+ +E    + +E + E  + TE+ + K  +T     +G   E
Sbjct: 1659 EVVVEE---GSCTEVVVEEGSCTEIVVEKGSDTEIVVEEGSATE 1699


>ref|XP_002603167.1| hypothetical protein BRAFLDRAFT_63199 [Branchiostoma floridae]
            gi|229288483|gb|EEN59178.1| hypothetical protein
            BRAFLDRAFT_63199 [Branchiostoma floridae]
          Length = 5785

 Score =  184 bits (468), Expect = 2e-43
 Identities = 310/1394 (22%), Positives = 536/1394 (38%), Gaps = 103/1394 (7%)
 Frame = -2

Query: 4883 KSINDGREKDKITAGLAIANADKGIGEPVIEEDVIQDQYTPTIGEEPTKECHEKEKVIEE 4704
            K+ ++  EK+K T        +  + E  ++ +   ++   T  EE T E    +K  E+
Sbjct: 4486 KADHETGEKEKNTE---TTTEETTVVEETVKTETRTEESAQTKKEETTSEMSVTQKETEK 4542

Query: 4703 SKFDANKNI-----------EEPTIEENDHSTTTILEKTIRDAHENDKAVEDAIIEDVVM 4557
            ++    + +           EE T+EE +  T TI E+++    E  +   + I  +   
Sbjct: 4543 TESTTEETVTEVSAKEETKREETTVEEAE-KTETITEESLEIKKEQTEVATEEITTEQTA 4601

Query: 4556 DYPKKAITEETLKDGLEENKVIEGRNIVGADKDIDDPFIVEDDKCDVTATTRENSIKDGH 4377
                   TE T ++ +E  K                    E+   +V+ T  +    +  
Sbjct: 4602 AVVATEKTEVTTEERVENKK--------------------EETTTEVSMTKEDTDTTENT 4641

Query: 4376 EEDKVIDEVKIVEADNDTSEHVREE-EVADNSTTTIM---EEPTNNDHEEDEIGLNATEG 4209
             E+ + +E+  VE   +T    +EE E+    T T     EE    + +++E  +  TE 
Sbjct: 4642 TEETIAEEMTAVEETENTEIATKEEVEIKKEETVTDKSEKEETKKGETKKEETTVEETEK 4701

Query: 4208 LEVVHAD----KDSEVPVIEENVVPYHSTTIVGDQTTNDGHEKDKGIEKLEIGGADQTTA 4041
             E +  +    K  +  V +E      +T +  ++T       ++ +E  E    +QTT 
Sbjct: 4702 TEAITEESAETKKEQTEVTKEETTTEETTAV--EETKKTKVTTEEKVETKE----EQTTT 4755

Query: 4040 TIGEEPVEDDHGETK------VAETLESASAHKDIGEHIIEEDVPDHSRT-------TIS 3900
             +     E +  ETK      V ET  +  A K+  E   EE V D S         T  
Sbjct: 4756 EVSMTKEETERTETKTEEMTAVEETENTEIATKEEVEIKKEETVTDKSEKEETKKGETKK 4815

Query: 3899 EEKVIERLEIIDA-------NKNSGVAITDNNVVLDDSTRTTEQEPTKNGEEENKVIQKL 3741
            EE  +E  E  +A        K     +T      +++T   E + TK   EE     K+
Sbjct: 4816 EETTVEETEKTEAITEESAETKKEQTEVTKEETTTEETTAVEETKKTKVTTEE-----KV 4870

Query: 3740 EISSADKVIGDPIIEDVPEHSTTTTGEEPVKEGHKENKVIEQIQILGLDKEIGGPVVEEN 3561
            E           + ++  E + T T E    E   EN  I   + + + KE      EE 
Sbjct: 4871 ETKEEQTTTEVSMTKEETERTETKTEEMTAVE-ETENTEITTKEKVDIKKE-ETKESEET 4928

Query: 3560 VAPNHSTTVIGEEAIHDGLEEDETIDGLQVDSTDKVNEEAITKEDLAQEHSTTTTQEKLI 3381
                  T V  +E      +++ET    + + T+   EE++  +      + T T+  + 
Sbjct: 4929 KKEETMTEVSVKEEEKTETKKEETTSVTEAEKTEVTKEESVEAKI-----NETATEVSVK 4983

Query: 3380 EDDHGENKVSTELAIGEASRDAVKQITKDGSITELSTVSDIKEMTKENS--QEEQMEAKK 3207
            E++  ENK             AVK+  K     E S  +  +E T E S  +EE+ E KK
Sbjct: 4984 EEEKTENKTE--------ETTAVKETKKTEGTMEESVETKKEETTTEVSVKEEEKTETKK 5035

Query: 3206 YEG-EVKELDLSTKTYEAPASAQKEETMTPSDEKEQHKNQ--HADSATDATTGKTN---- 3048
             E   V E + +  T +     +KEET T    KE+ K +    D+A    T KT     
Sbjct: 5036 EETTSVTEAEKTEVTKKDSVETKKEETTTEVSVKEEEKTETNKEDTAVVEETKKTEVTKE 5095

Query: 3047 EKGSEDLNDTSTGLNFEEADMLDGSSSLIPEVYXXXXXXXXXXXXEGTEDGPNSLEGVKK 2868
            EK      +T+T ++ +E +  +        V                     S+E  K 
Sbjct: 5096 EKVETKKEETTTEVSVKEEEKTETKKEETTAVTEAEKTQVTKE---------ESVEAKKA 5146

Query: 2867 ASLHDAESECRELTELS-------EEVNRATSIN--DSENNTSKKEQGSIKN---LEECI 2724
             ++   E+E  ELT          E V  A S++  ++E   SKK + ++       E  
Sbjct: 5147 ETVAATEAEKTELTTKQTVETTKEETVTVAVSVSQEEAEKTESKKTETTVAKETKKAEVT 5206

Query: 2723 KEETIDTKLRNHLGDREIQNQEVVASVGLTSEEQNFKPVSLSEKIECL-DAENLNKHVDD 2547
            KEE ++TK            +E    V +T +E   +     E    + +A+  +   +D
Sbjct: 5207 KEEKVETK------------EETTTEVSVTQKETMKEETKKEETAAVVTEAKETDVTTED 5254

Query: 2546 STTTHQ----LQENHAKAGSDFIPENKVHEKDTYSSKKEEQNVESFETSKEPEIPQSWQE 2379
            S  T +     QE   KA +    E  V EK    +KKEE   E  +  +E +  +   E
Sbjct: 5255 SVETQKDKTVTQEETEKAVATRTEETTVVEKADEDTKKEETTTEEIKAVEETKKTEEKVE 5314

Query: 2378 RTIDGEKTLIEQSERESMKLERSDESDSIEVLEHTGVMDGSHEASTIKEEHSSKIIDTET 2199
               +   T +  ++ ES K E   E         T V + + +   I EE +   I+ ET
Sbjct: 5315 TKKEETSTEVSMTKEESEKTEAKKEE--------TTVAEETDKTEAIIEEKAETTIE-ET 5365

Query: 2198 VEDKKIAEDDAVHDQSTDPCRYETV---DRSLVNDEKEQKSIELEPELEDDYYHTRAIEQ 2028
              +K + +++    + TD  + ET    +   +   KE+ + E++ E   D   T+  E 
Sbjct: 5366 TAEKSVTQEET---KKTDTKKDETTVGKETEKIEVAKEETATEVKKE---DNVETKKEET 5419

Query: 2027 GSNSKNQNXXXXXXXXXXXXEIIQDIIVEEHTANAAEEVIVQENSPKDDKVSKAPEGKVK 1848
                +N+               +  +  EE T    EE  V + + K  +V+KA   + K
Sbjct: 5420 ALVQENEKTEVTKEESQETKTEVS-VKEEEKTETKTEETTVLKEAEKTTEVTKAESVETK 5478

Query: 1847 ESDIVFMEASDSVRXXXXXXXXXXXXEGPKKSIDNFGTTEATLEEITKME-TNDKPNYSS 1671
            + +    E   SV+                K  +    TEA   EITK E T  K   + 
Sbjct: 5479 KEET---ETEVSVKEDEKTET---------KKEETTAITEAEKTEITKEESTETKKEETK 5526

Query: 1670 TESSLSEEQGMVEIPEKTESNNNETIFATPLTERLSLQDAETEDGELVDASSLASAKMIA 1491
            TE S+++E+      EKTE+   ET       +    +  +T+  E V+ +     K   
Sbjct: 5527 TEVSVTQEE-----VEKTEAKTEETKVVAETKKTKEEKTTDTKKEETVEETKEEDTKTKE 5581

Query: 1490 --------TQNQDV---DDVKQKKSSNLTDNRTEDKFTAENSEAAAQE------------ 1380
                    T+N +V   + V+ KK  ++T+  +  +   E +E   +E            
Sbjct: 5582 EETTVTEETKNTEVTKEESVEAKKDEHVTEATSVTQEETEKTETNKEETTIVEKTGKTEV 5641

Query: 1379 ------KSDIPVETSSIVLQSVDRDTET-----ASVEEITARKPSSVDILERNPQEPSKL 1233
                  +++   ET++ V    +  TET     A VEE    + +  D +E N +E    
Sbjct: 5642 TSEEKVETNFKEETTTEVSVKEEEKTETKKEETAVVEETKKTEATKEDRVETNKEETMTE 5701

Query: 1232 VSTKEELNKIGTQVMEAPLVEQTKREMNTQKEQDIKLEEDPATGIENSEQKISIPESDTE 1053
            VS KEE  KI T+  E   V + ++   T++E     +E+ AT +   E++ +  E+  E
Sbjct: 5702 VSVKEE-GKIETKKEETTAVMEAEKTEGTKEESVESKKEETATEVSVKEEEKT--ETKKE 5758

Query: 1052 KHISEQKDGDVILE 1011
            +  + +K G + L+
Sbjct: 5759 EMTAVEKSGKLKLQ 5772



 Score =  179 bits (455), Expect = 5e-42
 Identities = 279/1358 (20%), Positives = 525/1358 (38%), Gaps = 41/1358 (3%)
 Frame = -2

Query: 3998 KVAETLESASAHKDIGEHIIEEDVPDHSRTTISEEKVIERLEIIDANKNSGVAITDNNVV 3819
            K+ E  +  +A    G  I E    DH              E  +  KN+     +  VV
Sbjct: 4463 KIVELEKKVAAVSTDGGEIAETTKADH--------------ETGEKEKNTETTTEETTVV 4508

Query: 3818 ---LDDSTRTTEQEPTKNGEEENKVIQKLEISSADKVIGDPIIEDVPEHSTTTTGEEPVK 3648
               +   TRT E   TK  E  +++    + +   +   +  + +V     T   E  V+
Sbjct: 4509 EETVKTETRTEESAQTKKEETTSEMSVTQKETEKTESTTEETVTEVSAKEETKREETTVE 4568

Query: 3647 EGHKENKVIEQIQILGLDKEIGGPVVEENVAPNHSTTVIGEEAIHDGLEEDETIDGLQVD 3468
            E  K   + E+   L + KE    V  E +    +  V+  E     +  +E ++  + +
Sbjct: 4569 EAEKTETITEES--LEIKKE-QTEVATEEITTEQTAAVVATEKTE--VTTEERVENKKEE 4623

Query: 3467 STDKVNEEAITKEDLAQEHSTT--TTQEKLIEDDHGENKVSTELAIGEASRDAVKQITKD 3294
            +T +V+   +TKED     +TT  T  E++   +  EN   TE+A  E       +I K+
Sbjct: 4624 TTTEVS---MTKEDTDTTENTTEETIAEEMTAVEETEN---TEIATKEEV-----EIKKE 4672

Query: 3293 GSITELSTVSDIKEMTKENSQEEQMEAKKYEGEVKELDLSTKTYEAPASAQKEETMTPSD 3114
             ++T+ S     KE TK+       E KK E  V+E + +    E  A  +KE+T    +
Sbjct: 4673 ETVTDKSE----KEETKKG------ETKKEETTVEETEKTEAITEESAETKKEQTEVTKE 4722

Query: 3113 EKEQHKNQHADSATDATTGKTNEK--GSEDLNDTSTGLNFEEADMLDGSSSLIPEVYXXX 2940
            E    +    +  T  T   T EK    E+   T   +  EE +  +  +  +  V    
Sbjct: 4723 ETTTEETTAVEE-TKKTKVTTEEKVETKEEQTTTEVSMTKEETERTETKTEEMTAV---- 4777

Query: 2939 XXXXXXXXXEGTEDGPNSLEGVKKASLHDAESECRELTELSEEVNRATSINDSENNTSKK 2760
                     E TE        +KK      +SE +E T+  E     T++ ++E   +  
Sbjct: 4778 ------EETENTEIATKEEVEIKKEETVTDKSE-KEETKKGETKKEETTVEETEKTEAIT 4830

Query: 2759 EQGSIKNLE--ECIKEETI--DTKLRNHLGDREIQNQEVVASVGLTSEEQNFKPVSLSEK 2592
            E+ +    E  E  KEET   +T         ++  +E V     T EEQ    VS++++
Sbjct: 4831 EESAETKKEQTEVTKEETTTEETTAVEETKKTKVTTEEKVE----TKEEQTTTEVSMTKE 4886

Query: 2591 IECLDAENLNKHVDDSTTTHQLQENHAKAGSDFIPENKVHEKDTYSSKKEEQNVESFETS 2412
                + E      ++ T   +  EN      + +   K   K++  +KKEE   E   + 
Sbjct: 4887 ----ETERTETKTEEMTAVEET-ENTEITTKEKVDIKKEETKESEETKKEETMTEV--SV 4939

Query: 2411 KEPEIPQSWQERTI---DGEKTLIEQSERESMKLERSDESDSIEVLEHTGVMDGSHEAST 2241
            KE E  ++ +E T    + EKT  E ++ ES++ + ++ +  + V E     + + E + 
Sbjct: 4940 KEEEKTETKKEETTSVTEAEKT--EVTKEESVEAKINETATEVSVKEEEKTENKTEETTA 4997

Query: 2240 IKEEHSSKIIDTETVEDKK---IAEDDAVHDQSTDPCRYETVDRSLVNDEKEQKSIELEP 2070
            +KE   ++    E+VE KK     E     ++ T+  + ET   +     +  K   +E 
Sbjct: 4998 VKETKKTEGTMEESVETKKEETTTEVSVKEEEKTETKKEETTSVTEAEKTEVTKKDSVET 5057

Query: 2069 ELEDDYYHTRAIEQGSNSKNQNXXXXXXXXXXXXEIIQDIIVEEHTANAAEEVIVQENSP 1890
            + E+        E+     N+              + ++  VE        EV V+E   
Sbjct: 5058 KKEETTTEVSVKEEEKTETNKEDTAVVEETKKTE-VTKEEKVETKKEETTTEVSVKEEEK 5116

Query: 1889 KDDK------VSKAPEGKVKESDIVFMEASDSVRXXXXXXXXXXXXEGPKKSIDNFGTTE 1728
             + K      V++A + +V + + V  + +++V                K++++      
Sbjct: 5117 TETKKEETTAVTEAEKTQVTKEESVEAKKAETVAATEAEKTELTT----KQTVETTKEET 5172

Query: 1727 ATLEEITKMETNDKPNYSSTESSLSEEQGMVEIP--EKTESNNNETIFATPLTERLSLQD 1554
             T+      E  +K     TE+++++E    E+   EK E+   ET     +T++ ++++
Sbjct: 5173 VTVAVSVSQEEAEKTESKKTETTVAKETKKAEVTKEEKVETKE-ETTTEVSVTQKETMKE 5231

Query: 1553 AETEDGELVDASSLASAKMIATQNQDVDDVKQKKSSNLTDNRTEDKFTAENSEAAAQEKS 1374
             ET+  E     + A    + T+    D V+ +K   +T   TE        E    EK+
Sbjct: 5232 -ETKKEETAAVVTEAKETDVTTE----DSVETQKDKTVTQEETEKAVATRTEETTVVEKA 5286

Query: 1373 DIPVETSSIVLQSVDRDTETASVEEITARKPSSVDILERNPQEPSKLVSTKEELNKIGTQ 1194
            D   +      + +    ET   EE    K           +E S+    K+E   +  +
Sbjct: 5287 DEDTKKEETTTEEIKAVEETKKTEEKVETKKEETSTEVSMTKEESEKTEAKKEETTVAEE 5346

Query: 1193 VMEAPLVEQTKREM---NTQKEQDIKLEEDPATGIENSE-------QKISIPESDT---- 1056
              +   + + K E     T  E+ +  EE   T  +  E       +KI + + +T    
Sbjct: 5347 TDKTEAIIEEKAETTIEETTAEKSVTQEETKKTDTKKDETTVGKETEKIEVAKEETATEV 5406

Query: 1055 --EKHISEQKDGDVILERGDNTELNXXXXXXXXXXXXXSLKENQPESEESSLKDHETSDT 882
              E ++  +K+   +++  + TE+                +E+Q    E S+K+ E ++T
Sbjct: 5407 KKEDNVETKKEETALVQENEKTEVTK--------------EESQETKTEVSVKEEEKTET 5452

Query: 881  CVNIKTDILEQEEDPIKKHDQNLEEIKKEMKVDENVLEVQSTDHSNEINEPCDTTENVTI 702
                 T + E E+       +++E  K+E + + +V E + T+   E        E   I
Sbjct: 5453 KTEETTVLKEAEKTTEVTKAESVETKKEETETEVSVKEDEKTETKKEETTAITEAEKTEI 5512

Query: 701  AKKNLEATDPCEELKKPTETVDHDQSQEVLPEIEKTEVVNDGEIIKDQDTVFAEDRTVEQ 522
             K+  E+T+  +E  K   +V  ++ ++   + E+T+VV + +  K++ T    D   E+
Sbjct: 5513 TKE--ESTETKKEETKTEVSVTQEEVEKTEAKTEETKVVAETKKTKEEKTT---DTKKEE 5567

Query: 521  SIEEEKENDTLDKAGHKVDVEDQSNDMHHVNHLMKDTXXXXXXXXXXXXXEGDNIEKQSI 342
            ++EE KE DT  K       E+  N       + K+                +++E +  
Sbjct: 5568 TVEETKEEDTKTKEEETTVTEETKN-----TEVTKE----------------ESVEAKK- 5605

Query: 341  EEEAAKCVGVLDYKTRDKEVKDSDFTSNEGIANATYCKEKTEPDALTCVKELNQSVNASC 162
            +E   +   V   +T   E    +          T   EKT    +T  +++  +     
Sbjct: 5606 DEHVTEATSVTQEETEKTETNKEE----------TTIVEKTGKTEVTSEEKVETNFKEET 5655

Query: 161  DTEASIEEVLEQEEVSNTASEDLGEVVTGTELDIPKMD 48
             TE S++E    EE + T  E+   V    + +  K D
Sbjct: 5656 TTEVSVKE----EEKTETKKEETAVVEETKKTEATKED 5689



 Score =  119 bits (297), Expect = 1e-23
 Identities = 189/892 (21%), Positives = 353/892 (39%), Gaps = 78/892 (8%)
 Frame = -2

Query: 2486 ENKVHEKDTYSSKKEEQNVESFETSKEPEIPQSWQERTIDGEKTLIEQSERESMKLERSD 2307
            + +   +++  +KKEE   E   T KE E  +S  E T+  E +  E+++RE   +E ++
Sbjct: 4513 KTETRTEESAQTKKEETTSEMSVTQKETEKTESTTEETVT-EVSAKEETKREETTVEEAE 4571

Query: 2306 ESDSIEVLEHTGVMDGSHEASTIKEEHSSKIIDTETVEDKKIAEDDAVHDQSTDPCRYET 2127
            ++++I           + E+  IK+E +        V  ++I  +      +T+     T
Sbjct: 4572 KTETI-----------TEESLEIKKEQTE-------VATEEITTEQTAAVVATEKTEVTT 4613

Query: 2126 VDRSLVNDEKEQKSIELEPELEDDYYHTRAIEQGSNSKNQNXXXXXXXXXXXXEIIQDII 1947
             +R  V ++KE+ + E+    ED        E+                     I +++ 
Sbjct: 4614 EER--VENKKEETTTEVSMTKEDTDTTENTTEE--------------------TIAEEMT 4651

Query: 1946 VEEHTANAA----EEVIVQENSPKDDKVSKAP----EGKVKESDIVFMEASDSVRXXXXX 1791
              E T N      EEV +++     DK  K      E K +E+ +   E ++++      
Sbjct: 4652 AVEETENTEIATKEEVEIKKEETVTDKSEKEETKKGETKKEETTVEETEKTEAITEESAE 4711

Query: 1790 XXXXXXXEGPKKSIDNFGTTEATLEEITKMETNDKPNYSSTES-SLSEEQGMVEIP-EKT 1617
                      KK        E T EE T +E   K   ++ E     EEQ   E+   K 
Sbjct: 4712 T---------KKEQTEVTKEETTTEETTAVEETKKTKVTTEEKVETKEEQTTTEVSMTKE 4762

Query: 1616 ESNNNETIFATPLTERLSLQDAETEDGELVDASSLASAKMIATQNQDVDDVKQKKSSNLT 1437
            E+   ET      TE ++  + ETE+ E+     +   K      + V D  +K+ +   
Sbjct: 4763 ETERTET-----KTEEMTAVE-ETENTEIATKEEVEIKK-----EETVTDKSEKEETKKG 4811

Query: 1436 DNRTEDKFT--AENSEAAAQEKSDIPVETSSIVLQSVDRDTETASVEEITARKPSSVDIL 1263
            + + E+      E +EA  +E ++   E + +  +    + ET +VEE    K ++ + +
Sbjct: 4812 ETKKEETTVEETEKTEAITEESAETKKEQTEVTKEETTTE-ETTAVEETKKTKVTTEEKV 4870

Query: 1262 ERNPQEPSKLVS-TKEELNKIGTQVMEAPLVEQTKR-EMNTQKEQDIKLE---EDPATGI 1098
            E   ++ +  VS TKEE  +  T+  E   VE+T+  E+ T+++ DIK E   E   T  
Sbjct: 4871 ETKEEQTTTEVSMTKEETERTETKTEEMTAVEETENTEITTKEKVDIKKEETKESEETKK 4930

Query: 1097 ENSEQKISIPE---SDTEKH----ISEQKDGDVILERGDNTELN------------XXXX 975
            E +  ++S+ E   ++T+K     ++E +  +V  E     ++N                
Sbjct: 4931 EETMTEVSVKEEEKTETKKEETTSVTEAEKTEVTKEESVEAKINETATEVSVKEEEKTEN 4990

Query: 974  XXXXXXXXXSLKENQPESEES------------SLKDHETSDTCVNIKTDILEQEEDPIK 831
                       K+ +   EES            S+K+ E ++T     T + E E+  + 
Sbjct: 4991 KTEETTAVKETKKTEGTMEESVETKKEETTTEVSVKEEEKTETKKEETTSVTEAEKTEVT 5050

Query: 830  KHDQNLEEIKKEMKVDENVLEVQSTDHSNEINEPCDTTENVTIAKK-----NLEATDPCE 666
            K D ++E  K+E   + +V E + T+ + E     + T+   + K+       E T    
Sbjct: 5051 KKD-SVETKKEETTTEVSVKEEEKTETNKEDTAVVEETKKTEVTKEEKVETKKEETTTEV 5109

Query: 665  ELKKPTETVDHDQSQEVLPEIEKTEVVNDGEI-IKDQDTVFAEDR-----TVEQSIEEEK 504
             +K+  +T    +    + E EKT+V  +  +  K  +TV A +      T +Q++E  K
Sbjct: 5110 SVKEEEKTETKKEETTAVTEAEKTQVTKEESVEAKKAETVAATEAEKTELTTKQTVETTK 5169

Query: 503  ENDTLDKAGHKVDVEDQSNDMHHVNHLMKDTXXXXXXXXXXXXXEGDNIEKQSIEEEAAK 324
            E           +  +++        + K+T                  EK   +EE   
Sbjct: 5170 EETVTVAVSVSQEEAEKTESKKTETTVAKETKKAEVTKE----------EKVETKEETTT 5219

Query: 323  CVGVLDYKTRDK------------EVKDSDFTSNEGI---ANATYCKEKTEPDALTCVKE 189
             V V   +T  +            E K++D T+ + +    + T  +E+TE    T  +E
Sbjct: 5220 EVSVTQKETMKEETKKEETAAVVTEAKETDVTTEDSVETQKDKTVTQEETEKAVATRTEE 5279

Query: 188  LNQSVNASCDT---EASIEEVLEQEEVSNTASE-DLGEVVTGTELDIPKMDN 45
                  A  DT   E + EE+   EE   T  + +  +  T TE+ + K ++
Sbjct: 5280 TTVVEKADEDTKKEETTTEEIKAVEETKKTEEKVETKKEETSTEVSMTKEES 5331



 Score =  102 bits (255), Expect = 8e-19
 Identities = 149/654 (22%), Positives = 257/654 (39%), Gaps = 24/654 (3%)
 Frame = -2

Query: 4910 AHFTTTTEEKSINDGREKDKITAGLAIANADKGIGEPVIEEDVIQDQYTPTIGEEPTKEC 4731
            A  T  T ++++   +E + +T  ++++  +    E    E  +  +   T   E TKE 
Sbjct: 5154 AEKTELTTKQTVETTKE-ETVTVAVSVSQEEAEKTESKKTETTVAKE---TKKAEVTKE- 5208

Query: 4730 HEKEKVIEESKFDANKNIEEPTIEENDHSTTTILEKTIRDAHENDKAVEDAII----EDV 4563
             EK +  EE+  + +   +E   EE     T  +   + +A E D   ED++     + V
Sbjct: 5209 -EKVETKEETTTEVSVTQKETMKEETKKEETAAV---VTEAKETDVTTEDSVETQKDKTV 5264

Query: 4562 VMDYPKKAI---TEETL------KDGLEENKVIEGRNIVGADKDIDDPFIV--EDDKCDV 4416
              +  +KA+   TEET       +D  +E    E    V   K  ++      E+   +V
Sbjct: 5265 TQEETEKAVATRTEETTVVEKADEDTKKEETTTEEIKAVEETKKTEEKVETKKEETSTEV 5324

Query: 4415 TATTRENSIKDGH-EEDKVIDEVKIVEAD-NDTSEHVREEEVADNSTTTIMEEPTNNDHE 4242
            + T  E+   +   EE  V +E    EA   + +E   EE  A+ S T    + T+   +
Sbjct: 5325 SMTKEESEKTEAKKEETTVAEETDKTEAIIEEKAETTIEETTAEKSVTQEETKKTDTKKD 5384

Query: 4241 EDEIGLNATEGLEVVHADKDSEVPVIEENVVPYHSTTIVGDQTTNDGHEKDKGIEKLEIG 4062
            E  +G   TE +EV   +  +EV   +        T +V +    +  +++    K E+ 
Sbjct: 5385 ETTVG-KETEKIEVAKEETATEVKKEDNVETKKEETALVQENEKTEVTKEESQETKTEVS 5443

Query: 4061 GADQ--TTATIGEEPVEDDHGETKVAETLESASAHKDIGEHIIEEDVPDHSRTTISEEKV 3888
              ++  T     E  V  +  +T      ES    K+  E  +     + + T   E   
Sbjct: 5444 VKEEEKTETKTEETTVLKEAEKTTEVTKAESVETKKEETETEVSVKEDEKTETKKEETTA 5503

Query: 3887 IERLEIIDANKNSGVAITDNNVVLDDSTRTTEQEPTKNGEEENKVIQKLEISSADKVIGD 3708
            I   E  +  K             + S    E E T+   EE KV+ + + +  +K    
Sbjct: 5504 ITEAEKTEITKEESTETKKEETKTEVSVTQEEVEKTEAKTEETKVVAETKKTKEEKTTDT 5563

Query: 3707 PIIEDVPEHSTTTTGEEPVKEGHKENKVIEQIQILGLDKEIGGPVVEENVAPNHSTTVIG 3528
               E V E     T EE  K   +E  V E+ +   + KE      ++      +T+V  
Sbjct: 5564 KKEETVEE-----TKEEDTKTKEEETTVTEETKNTEVTKEESVEAKKDEHV-TEATSVTQ 5617

Query: 3527 EEAIHDGLEEDETIDGLQVDSTDKVNEEAITKEDLAQEHSTTTT---QEKLIEDDHGENK 3357
            EE       ++ET    +   T+  +EE +  E   +E +TT     +E+  E    E  
Sbjct: 5618 EETEKTETNKEETTIVEKTGKTEVTSEEKV--ETNFKEETTTEVSVKEEEKTETKKEETA 5675

Query: 3356 VSTELAIGEASRDAVKQITKDGSITELSTVSDIKEMTKENSQEEQMEAKKYEGEVKELDL 3177
            V  E    EA+++   +  K+ ++TE+S   + K  TK+      MEA+K EG       
Sbjct: 5676 VVEETKKTEATKEDRVETNKEETMTEVSVKEEGKIETKKEETTAVMEAEKTEG------- 5728

Query: 3176 STKTYEAPASAQKEETMTPSDEKEQHKNQHADSATDAT--TGKTNEKGSEDLND 3021
               T E    ++KEET T    KE+ K +       A   +GK   +G E  N+
Sbjct: 5729 ---TKEESVESKKEETATEVSVKEEEKTETKKEEMTAVEKSGKLKLQGRERRNE 5779


>ref|XP_001311646.1| hypothetical protein [Trichomonas vaginalis G3]
            gi|121893464|gb|EAX98716.1| hypothetical protein
            TVAG_480920 [Trichomonas vaginalis G3]
          Length = 1996

 Score =  183 bits (465), Expect = 4e-43
 Identities = 339/1578 (21%), Positives = 590/1578 (37%), Gaps = 80/1578 (5%)
 Frame = -2

Query: 4751 EEPTKECHEKEKVIEESKFDANKNIEEPTIEENDHSTTTILEKTIRDAHENDKAVEDAII 4572
            EE +    EKE++    K   N  +    I +   ST  + EK      E  K+ E+   
Sbjct: 526  EEISSSRKEKEEISSSRKEKENTQLGLSNIIKGKLSTFDVEEKPKEREFEVKKSSEE--- 582

Query: 4571 EDVVMDYPKKAITEE--TLKDGLEENK----VIEGRNIVGADKDIDDPFIVEDDKCDVTA 4410
            E+   + P + ITE      D  E  K    V +  N   ++K ID     E +K     
Sbjct: 583  ENKNNEIPSEIITESYNETNDDFESEKPKEEVSKSENDFESEKHIDSAQ-KESEKEQAKQ 641

Query: 4409 TTRENSIKDGHEEDKVIDEVKI-VEADNDTSEHVREEEVADNSTTTIMEEPTNNDH--EE 4239
            +   ++++   E +K  +  K   E+DND     ++E+  D  T    EE    D   + 
Sbjct: 642  SEETSNLESEFESEKHKESSKEETESDNDKLSDKKQEK--DKETDDDFEEEGKKDQITQS 699

Query: 4238 DEIGLNATEGLEVVHADKDSEVPVIEENVVPYHSTTIVGDQTTNDGHEKDKGIEKLEIGG 4059
            +E  LN     E    DK+ +   IEE   P +      ++ T + + + + + K     
Sbjct: 700  EEEKLNEIISSE---GDKEKDFHFIEEKK-PNNEIQDDFEEATEEKYSEREELMKPTEPD 755

Query: 4058 ADQTTATIGEEPVEDDHGETKVAETLESASAHKDIGEHIIEEDVPDHSRTTISEEKVIER 3879
              Q      EE  +++  E K  +  E+    +   E I E  V D  +    EE+    
Sbjct: 756  FQQ------EEKQKEEVNEEKQIDRKENDFLEETKEEQIHEVKVSDDIKDDFKEEQK--- 806

Query: 3878 LEIIDANKNSGVAITDNNVVLDDSTRTTEQEPTKNGEEENKVIQKLEISSADKVIGDPII 3699
             EI   + N+           ++ST  ++ E     EEE+KV  K   + +++   +   
Sbjct: 807  -EIEHESNNA-----------EESTNKSK-EVVSETEEESKVQTKERENPSEEETKEEPF 853

Query: 3698 EDVPEHSTTTTGEEPVKEGHKENKVIEQIQILGLDKEIGGPVVEENVAPNHSTTVIGEEA 3519
            ED  +  T     E +KE   E++                   EEN   N   T   EE 
Sbjct: 854  EDEYKEETKDENTEEIKEEPFEDET-----------------KEENKDKNKEETK-EEEP 895

Query: 3518 IHDGLEEDETIDGLQVDSTDKVNEEAITKEDLAQEHSTTTTQEKLIEDD-----HGENKV 3354
              D  +E+E  +    ++ ++  EE  TKE+   E+   T +E+  ED+       ENK 
Sbjct: 896  FEDETKEEEPFED---ENKEETKEE--TKEENKDENKEETKEEEPFEDETKEENKDENKE 950

Query: 3353 STELAIGEASRDAVKQITKDGSITE----------------LSTVSDIKEMTKENSQEEQ 3222
             T+    + S++  K+ TKD +  E                     + KE TKE ++EE 
Sbjct: 951  ETKEETKDKSKEETKEETKDETKEEEPFDGETKEENKDENKEENKDENKEETKEENKEET 1010

Query: 3221 MEAKKYEGEVKELDLSTKTYEAPASAQKEETMTPSDEKEQHKNQHADSATDATTGKTNE- 3045
             E + +E E KE +   +T E      KEE     + KE+ K ++ D   + T  +T E 
Sbjct: 1011 KEEEPFEDETKE-ETKDETKEETKDETKEEEPFEDESKEETKEENKDENKEETKEETKEE 1069

Query: 3044 -KGSEDLNDTSTGLNFEEADMLDGSSSLIPEVYXXXXXXXXXXXXEGTEDGPNSLEGVKK 2868
             K  E   D +     EE    +       E              E  ED  +  E   K
Sbjct: 1070 TKEEEPFEDENKEETKEETKEDEPFEDETKEENKEEEPFEDENKEETKEDNKDDYEEETK 1129

Query: 2867 ASLHDAESE------CRELTELSEEVNRATSINDSENNTSKKEQ--GSIKNLEECI--KE 2718
               +  E E         +  + EE        D E     +E+    +K   E I  K+
Sbjct: 1130 HENNVQEQEDEPTNKANPIASVDEEFEEVFKDEDREFEKHSQEELNREVKEEREFIPQKD 1189

Query: 2717 ETIDTKLRNHLGDREIQNQEVVASVGLTSEE------------QNFKPVSLSEKIECLDA 2574
            ET D +  +   + EI+ ++ +    +  EE            +  K   + EK E +  
Sbjct: 1190 ETKDQESNHEDFEEEIKEEQKIDEDTIKEEEEQKTEKVQNDFDEEIKEEDIKEKHEEVTK 1249

Query: 2573 ENLNKHVDDSTTTHQLQENHAKAGSDFIPENKVHEKDTYSSKKEEQNVESFETSKEPEIP 2394
            + +  + + +    Q QE  +    D   +N   +K+  + +  E+ V++++  +E +  
Sbjct: 1250 DKVEMNEEQNDEEKQQQEVESTIEEDITEQNVEPKKEEQTIQDFEEEVQNYDDKREEQSE 1309

Query: 2393 QSWQERTIDGEKTLIEQSERESMKLERSDESDSIEVLEHTGVMDGSHEASTIKEEHSSKI 2214
            +  +ER I      IEQ + E  K E  +E +  E L         HE    KEE   + 
Sbjct: 1310 KVHEEREI---VLNIEQPQEEEKKEELHEEEEKKEEL---------HEEEEKKEELHEEE 1357

Query: 2213 IDTETVEDKKIAEDDAVHDQSTDPCRYETVDRSLVNDEKEQKSIEL-EPELEDDYYHTRA 2037
               E  E++K  E     ++ T    +E  +  +    +E+K  EL E E +++  H   
Sbjct: 1358 KKEELHEEEKKEEQLHEEEEETKEELHEEEEEKIEKLHEEEKKEELHEEEKKEEQLHEEE 1417

Query: 2036 IEQGSNSKNQNXXXXXXXXXXXXEIIQDIIVEEHTANAAEEVIVQENSPKDDKVSKAPEG 1857
             E+     ++                ++   E H     EE+  +E   K +++ +  E 
Sbjct: 1418 EEKKEEQLHEEEEKKEELHE------EEKKEELHEEEKKEELHEEEEEEKKEELHEEEEE 1471

Query: 1856 KVKESDIVFMEASDSVRXXXXXXXXXXXXEGPKKSIDNFGTTEATLEEITKMETNDKPNY 1677
            + KE   +  E                  E  KK   +    E   EE+ + E   +   
Sbjct: 1472 EKKEE--LHEEEEKKEEEEEKIEKLHEEEEEEKKEELHEEEEEEKKEELHEEEEKKEEEE 1529

Query: 1676 SSTESSLSEEQGMVEIPEKTESNNNETIFATPLTERLSLQDAETEDGELVDASSLASAKM 1497
               E    EE       EK +   NE I   P  + +   ++E E+    D       K 
Sbjct: 1530 EKIEKLHEEE-------EKKKEQTNEEINYNPAIKEVEGPESEEENKYRKDEEDFEDEK- 1581

Query: 1496 IATQNQDVDDVKQKKSSNLTDNRTEDKFTAENSEAAAQEKSDIPVETSSIVLQSVDRDTE 1317
                N++ D  KQK+ S       E+  T EN     +E +   +E SS+ +  V  +TE
Sbjct: 1582 ----NEESDYKKQKEESESVAKELEETST-ENRNNNQEETNQPKLENSSLNITEVKEETE 1636

Query: 1316 -----TASVEEITARKPSSVD------ILERNPQ------EPSKLVSTKEELNKIGTQVM 1188
                 T   E     +    D      I + N Q         K +  +EE      +++
Sbjct: 1637 EKVNITDDFETENQNEDRETDAETEKAIHQENEQIREKDFHDEKQIENEEEKQ----EIL 1692

Query: 1187 EAPLVE---QTKREMNTQKEQDIKLEEDPATGIENSEQKISIPESDTEK----HISEQKD 1029
            + P+ E   Q + +    +E++ K EE+    +   E+KI     + EK    H  E+K 
Sbjct: 1693 KEPIEERNFQQENDFKDNEEEEKKEEEEKIEKLHEKEEKIEKLHEEEEKKEELHEEEEKK 1752

Query: 1028 GDVILERGD-NTELNXXXXXXXXXXXXXSLKENQPESEESSLKDHETSDTCVNIKTDILE 852
             + + E  +   EL+               + ++ E +E  L + E  +  ++ +    E
Sbjct: 1753 EEQLHEEEEKKEELHEEEKKEELHEEEKKEELHEEEKKEEQLHEEEKKEEQLHEEEKKEE 1812

Query: 851  QEEDPIKKHDQNLEEIKKEMKVDENVLEVQSTDHSNEINEPCDTTENVTIAKKNLEATDP 672
            Q  +  KK +Q  EE KKE ++ E   + +   H  E  E     E     +K  E    
Sbjct: 1813 QLHEEEKKEEQLHEEEKKEEQLHEEEKKEEQL-HEEEKKEELHEEE-----EKKEEQLHE 1866

Query: 671  CEELKKPTETVDHDQSQEVLPEIEKTEVVNDGEIIKDQDTVFAEDRTVEQSIEEEKENDT 492
             EE KK  +  + ++ +E L E EK E        +  + V   +  +EQ  EEE++N+ 
Sbjct: 1867 EEEEKKEEQLHEEEEKKEELHEEEKKEE-------QPHEEVVVVEEKMEQPQEEEEDNEA 1919

Query: 491  LDKAGHKVDVEDQSNDMHHVNHLMKDTXXXXXXXXXXXXXEGDNIEKQSIEEEAAKCVGV 312
             D      D +++ +    V   +++                + +EK+ IEEE  +    
Sbjct: 1920 -DGIHSLSDFDEEISTEEKVEIKVQEKEENNDFDAEEEKILEEKLEKEIIEEENNE---T 1975

Query: 311  LDYKTRDKEVKDSDFTSN 258
             D + +  E ++ DF ++
Sbjct: 1976 EDDRPKKSEEEEDDFEND 1993



 Score =  119 bits (299), Expect = 6e-24
 Identities = 240/1181 (20%), Positives = 456/1181 (38%), Gaps = 23/1181 (1%)
 Frame = -2

Query: 4892 TEEKSINDGREKDKITAGLAIANADKGIGEPVIE--EDVIQDQYTPTIGEEPTKECHEKE 4719
            T+E++ ++ +E++         N D+   E   E  E+  ++    T  EEP ++  ++E
Sbjct: 964  TKEETKDETKEEEPFDGETKEENKDENKEENKDENKEETKEENKEETKEEEPFEDETKEE 1023

Query: 4718 KVIEESKFDANKNIEEPTIEENDHSTTTILEKTIRDAHENDKAVEDAIIEDVVMDYPKKA 4539
               E  +   ++  EE   E+     T    K        ++  E+   E+   D  K+ 
Sbjct: 1024 TKDETKEETKDETKEEEPFEDESKEETKEENKDENKEETKEETKEETKEEEPFEDENKEE 1083

Query: 4538 ITEETLKDGLEENKVIEGRNIVGADKDIDDPFIVEDDKCDVTATTR-ENSIKDGHEEDKV 4362
              EET +D   E++  E        +D +     ED+K D    T+ EN++++  +ED+ 
Sbjct: 1084 TKEETKEDEPFEDETKEENKEEEPFEDENKEETKEDNKDDYEEETKHENNVQE--QEDEP 1141

Query: 4361 IDEVKIVEADNDTSEHVREEEVADNSTTTIMEEPTNNDHEEDEIGL---NATEGLEVVHA 4191
             ++   + + ++  E V ++E  D       +E  N + +E+   +   + T+  E  H 
Sbjct: 1142 TNKANPIASVDEEFEEVFKDE--DREFEKHSQEELNREVKEEREFIPQKDETKDQESNHE 1199

Query: 4190 DKDSEVPVIEENVVPYHSTTIVGDQTTND-GHEKDKGIEKLEIGGADQTTATIGEEPVED 4014
            D + E+   EE  +   +     +Q T    ++ D+ I++ +I    +       E  E+
Sbjct: 1200 DFEEEIK--EEQKIDEDTIKEEEEQKTEKVQNDFDEEIKEEDIKEKHEEVTKDKVEMNEE 1257

Query: 4013 DHGETKVAETLESASAHKDIGEHIIEEDVPDHSRTTISEEKVIERLE-----IIDANKNS 3849
             + E K  + +ES           IEED+ + +     EE+ I+  E       D  +  
Sbjct: 1258 QNDEEKQQQEVEST----------IEEDITEQNVEPKKEEQTIQDFEEEVQNYDDKREEQ 1307

Query: 3848 GVAITDNNVVLDDSTRTTEQEPTKNGEEENKVIQKLEISSADKVIGDPIIEDVPEHSTTT 3669
               + +   ++ +  +  E+E  +   EE +  ++L      K       E++ E     
Sbjct: 1308 SEKVHEEREIVLNIEQPQEEEKKEELHEEEEKKEELHEEEEKK-------EELHE----- 1355

Query: 3668 TGEEPVKEGHKENKVIEQIQILGLDKEIGGPVVEENVAPNHSTTVIGEEAIHDGLEEDET 3489
              EE  +E H+E K  EQ+                     H      +E +H+  EE+E 
Sbjct: 1356 --EEKKEELHEEEKKEEQL---------------------HEEEEETKEELHE--EEEEK 1390

Query: 3488 IDGL-QVDSTDKVNEEAITKEDLAQEHSTTTTQEKLIEDDHGENKVSTELAIGEASRDAV 3312
            I+ L + +  ++++EE   +E L +E      +EK  E  H E +   EL   E   +  
Sbjct: 1391 IEKLHEEEKKEELHEEEKKEEQLHEEE-----EEKKEEQLHEEEEKKEELHEEEKKEELH 1445

Query: 3311 KQITKDGSITELSTVSDIKEMTKENSQEEQMEAKKYEGEVKELDLS--TKTYEAPASAQK 3138
            ++  K+    E     + KE   E  +EE+ E    E E KE +     K +E     +K
Sbjct: 1446 EEEKKEELHEE--EEEEKKEELHEEEEEEKKEELHEEEEKKEEEEEKIEKLHEEEEEEKK 1503

Query: 3137 EETMTPSDE---KEQHKNQHADSATDATTGKTNEKGSEDLNDTSTGLNFEEA-DMLDGSS 2970
            EE     +E   +E H+ +      +    K +E+  +    T+  +N+  A   ++G  
Sbjct: 1504 EELHEEEEEEKKEELHEEEEKKEEEEEKIEKLHEEEEKKKEQTNEEINYNPAIKEVEGPE 1563

Query: 2969 SLIPEVYXXXXXXXXXXXXEGTEDGPNSLEGVKKASLHDAESECRELTELSEEVNRATSI 2790
            S     Y               ED  N     KK    ++ES  +EL E S E NR  + 
Sbjct: 1564 SEEENKYRKDEEDF--------EDEKNEESDYKKQK-EESESVAKELEETSTE-NR--NN 1611

Query: 2789 NDSENNTSKKEQGSIKNLEECIKEETIDTKLRNHLGDREIQNQEVVASVGLTSEEQNFKP 2610
            N  E N  K E  S+   E  +KEET +    N   D E +NQ                 
Sbjct: 1612 NQEETNQPKLENSSLNITE--VKEETEEKV--NITDDFETENQ----------------- 1650

Query: 2609 VSLSEKIECLDAENLNKHVDDSTTTHQLQENHAKAGSDFIPENKVHEKDTYSSKKEEQNV 2430
                         N ++  D  T     QEN            ++ EKD +  K+ E   
Sbjct: 1651 -------------NEDRETDAETEKAIHQEN-----------EQIREKDFHDEKQIENEE 1686

Query: 2429 ESFETSKEPEIPQSWQERTIDGEKTLIEQSERESMKLERSDESDSIEVL-EHTGVMDGSH 2253
            E  E  KEP   +++Q+          E   +++ + E+ +E + IE L E    ++  H
Sbjct: 1687 EKQEILKEPIEERNFQQ----------ENDFKDNEEEEKKEEEEKIEKLHEKEEKIEKLH 1736

Query: 2252 EASTIKEE-HSSKIIDTETVEDKKIAEDDAVHDQSTDPCRYETVDRSLVNDEKEQKSIEL 2076
            E    KEE H  +    E + +++  +++   ++  +    E     L  +EK+++ +  
Sbjct: 1737 EEEEKKEELHEEEEKKEEQLHEEEEKKEELHEEEKKEELHEEEKKEELHEEEKKEEQLHE 1796

Query: 2075 EPELEDDYYHTRAIEQGSNSKNQNXXXXXXXXXXXXEIIQDIIVEE--HTANAAEEVIVQ 1902
            E + E+  +     E+  + + +             ++ ++   EE  H     EE + +
Sbjct: 1797 EEKKEEQLHEEEKKEEQLHEEEKKEEQLHEEEKKEEQLHEEEKKEEQLHEEEKKEE-LHE 1855

Query: 1901 ENSPKDDKVSKAPEGKVKESDIVFMEASDSVRXXXXXXXXXXXXEGPKKSIDNFGTTEAT 1722
            E   K++++ +  E K +E      E  + +                KK        E  
Sbjct: 1856 EEEKKEEQLHEEEEEKKEEQLHEEEEKKEELHEE------------EKKE-------EQP 1896

Query: 1721 LEEITKMETNDKPNYSSTESSLSEEQGMVEIPEKTESNNNETIFATPLTERLSLQDAETE 1542
             EE+  +E  +K      E   +E  G+  + +  E  + E      + E+    D + E
Sbjct: 1897 HEEVVVVE--EKMEQPQEEEEDNEADGIHSLSDFDEEISTEEKVEIKVQEKEENNDFDAE 1954

Query: 1541 DGELVDASSLASAKMIATQNQDVDDVKQKKSSNLTDNRTED 1419
            + ++++       ++I  +N + +D + KKS    D+   D
Sbjct: 1955 EEKILEEK--LEKEIIEEENNETEDDRPKKSEEEEDDFEND 1993



 Score =  110 bits (276), Expect = 3e-21
 Identities = 232/1202 (19%), Positives = 456/1202 (37%), Gaps = 89/1202 (7%)
 Frame = -2

Query: 3458 KVNEEAITKEDLAQEHSTTTTQEKLIEDDHGENKVSTELAIGEASRDAVKQITKDGSITE 3279
            K +E  + K D+A+   T+            + K+   LA    S     + +   S   
Sbjct: 370  KKDEAFMRKPDVAKRPKTSAEVSPPFSSKPPQ-KIQQNLAPTRLSLRRSSESSNQSSQVS 428

Query: 3278 LSTVSDIKEMTKENSQEEQMEAKKYEGEVKELDLSTKTYEAPASA--QKEETMTPSDEKE 3105
             S    +  ++    ++E++ + + E E  E+  S K  E  +S+  +KEE  +   EKE
Sbjct: 429  SSRSEKLPHISSSRKEKEEISSSRKEKE--EISSSRKEKEEISSSRKEKEEISSSRKEKE 486

Query: 3104 QHKNQHADSATDATTGKTNEKGSEDLND-TSTGLNFEEADMLDGSSSLIPEVYXXXXXXX 2928
            +  +   +    +++ K  E+ S    +      + +E + +  S     E+        
Sbjct: 487  EISSSRKEKEEISSSRKEKEEISSSRKEKEEISSSRKEKEEISSSRKEKEEI------SS 540

Query: 2927 XXXXXEGTEDG-PNSLEGVKKASLHDAESECR----ELTELSEEVNRATSI--------- 2790
                 E T+ G  N ++G  K S  D E + +    E+ + SEE N+   I         
Sbjct: 541  SRKEKENTQLGLSNIIKG--KLSTFDVEEKPKEREFEVKKSSEEENKNNEIPSEIITESY 598

Query: 2789 ---NDSENNTSKKEQGSIKNLEECIKEETIDTKLRNHLGDREIQNQEVVASVGLTSEEQN 2619
               ND   +   KE+ S K+  +   E+ ID+  +    ++  Q++E  +++    E + 
Sbjct: 599  NETNDDFESEKPKEEVS-KSENDFESEKHIDSAQKESEKEQAKQSEE-TSNLESEFESEK 656

Query: 2618 FKPVSLSEKIECLDAENLNKHVDDSTTTHQLQENHAKAGSDFIPENKVHE---------- 2469
             K  S  E     D  +  K   D  T    +E   K       E K++E          
Sbjct: 657  HKESSKEETESDNDKLSDKKQEKDKETDDDFEEEGKKDQITQSEEEKLNEIISSEGDKEK 716

Query: 2468 --------------KDTYSSKKEEQNVESFETSK--EPEIPQSWQERTIDGEKTLIEQSE 2337
                          +D +    EE+  E  E  K  EP+  Q  +++    E+  I++ E
Sbjct: 717  DFHFIEEKKPNNEIQDDFEEATEEKYSEREELMKPTEPDFQQEEKQKEEVNEEKQIDRKE 776

Query: 2336 RESMKLERSDESDSIEVLEHTGVMDG--------SHEASTIKEE-HSSKIIDTETVEDKK 2184
             +   LE + E    EV     + D          HE++  +E  + SK + +ET E+ K
Sbjct: 777  NDF--LEETKEEQIHEVKVSDDIKDDFKEEQKEIEHESNNAEESTNKSKEVVSETEEESK 834

Query: 2183 I--------AEDDAVHDQSTDPCRYETVDRSL--------------------VNDEKEQK 2088
            +        +E++   +   D  + ET D +                       + KE++
Sbjct: 835  VQTKERENPSEEETKEEPFEDEYKEETKDENTEEIKEEPFEDETKEENKDKNKEETKEEE 894

Query: 2087 SIELEPELEDDYYHTRAIEQGSNSKNQNXXXXXXXXXXXXEIIQDIIVEEHTANAAEEVI 1908
              E E + E+ +      E    +K +N               +D   EE+     EE  
Sbjct: 895  PFEDETKEEEPFEDENKEETKEETKEENKDENKEETKEEEP-FEDETKEENKDENKEETK 953

Query: 1907 VQENSPKDDKVSKAPEGKVKESDIVFMEASDSVRXXXXXXXXXXXXEGPKKSIDNFGTTE 1728
             +      ++  +  + + KE +    E  +  +            E  K+        E
Sbjct: 954  EETKDKSKEETKEETKDETKEEEPFDGETKEENKDENKEENKDENKEETKEENKEETKEE 1013

Query: 1727 ATLEEITKMETNDKPNYSSTESSLSEEQGMVEIPEKTESNNNETIFATPLTERLSLQDAE 1548
               E+ TK ET D+    + + +  EE    E  E+T+  N +        E       E
Sbjct: 1014 EPFEDETKEETKDETKEETKDETKEEEPFEDESKEETKEENKD----ENKEETKEETKEE 1069

Query: 1547 TEDGELVDASSLASAKMIATQNQDVDDVKQKKSSNLTDNRTEDKFTAENSEAAAQE-KSD 1371
            T++ E  +  +    K    +++  +D  ++      +N+ E+ F  EN E   ++ K D
Sbjct: 1070 TKEEEPFEDENKEETKEETKEDEPFEDETKE------ENKEEEPFEDENKEETKEDNKDD 1123

Query: 1370 IPVETSSIVLQSVDRDTETASVEEITARKPSSVDILERNPQEPSKLVSTKEELNKIGTQV 1191
               ET          D  T     I +      ++ +   +E  K   ++EELN+   + 
Sbjct: 1124 YEEETKHENNVQEQEDEPTNKANPIASVDEEFEEVFKDEDREFEK--HSQEELNREVKEE 1181

Query: 1190 ME-APLVEQTKREMNTQK--EQDIKLEE--DPATGIENSEQKISIPESDTEKHISEQKDG 1026
             E  P  ++TK + +  +  E++IK E+  D  T  E  EQK    ++D ++ I E+   
Sbjct: 1182 REFIPQKDETKDQESNHEDFEEEIKEEQKIDEDTIKEEEEQKTEKVQNDFDEEIKEED-- 1239

Query: 1025 DVILERGDNTELNXXXXXXXXXXXXXSLKENQPESEESSLKDHETSDTCVNIKTDILEQE 846
              I E+ +                    K+    +EE + ++ +  +    I+ DI EQ 
Sbjct: 1240 --IKEKHEEV-----------------TKDKVEMNEEQNDEEKQQQEVESTIEEDITEQN 1280

Query: 845  EDPIKKHDQNLEEIKKEMKVDENVLEVQSTDHSNEINEPCDTTENVTIAKKNLEATDPCE 666
             +P KK +Q +++ ++E++  ++  E Q    S +++E  +   N+   ++  +  +  E
Sbjct: 1281 VEP-KKEEQTIQDFEEEVQNYDDKREEQ----SEKVHEEREIVLNIEQPQEEEKKEELHE 1335

Query: 665  ELKKPTETVDHDQSQEVLPEIEKTEVVNDGEIIKDQDTVFAEDRTVEQSIEEEKENDTLD 486
            E +K  E  + ++ +E L E EK E +++ E  K ++ +  E+   ++ + EE+E     
Sbjct: 1336 EEEKKEELHEEEEKKEELHEEEKKEELHEEE--KKEEQLHEEEEETKEELHEEEEEKI-- 1391

Query: 485  KAGHKVDVEDQSNDMHHVNHLMKDTXXXXXXXXXXXXXEGDNIEKQSIEEEAAKCVGVLD 306
                K+  E++  ++H      ++                +  +K+ + EE  K      
Sbjct: 1392 ---EKLHEEEKKEELHE-EEKKEEQLHEEEEEKKEEQLHEEEEKKEELHEEEKK------ 1441

Query: 305  YKTRDKEVKDSDFTSNEGIANATYCKEKTEPDALTCVKELNQSVNASCDTEASIEEVLEQ 126
             +   +E K  +    E         E+ E +     +EL++      + E  IE++ E+
Sbjct: 1442 -EELHEEEKKEELHEEEEEEKKEELHEEEEEEK---KEELHEEEEKKEEEEEKIEKLHEE 1497

Query: 125  EE 120
            EE
Sbjct: 1498 EE 1499



 Score = 99.8 bits (247), Expect = 7e-18
 Identities = 188/909 (20%), Positives = 342/909 (37%), Gaps = 69/909 (7%)
 Frame = -2

Query: 2606 SLSEKIECLDAENLNKHVDDSTTTHQLQENHAKAGSDFIPENKVHEKDTYSSKKEEQNVE 2427
            S SEK+  + +    K    S+   + + + ++   + I  ++  +++  SS+KE++ + 
Sbjct: 430  SRSEKLPHISSSRKEKEEISSSRKEKEEISSSRKEKEEISSSRKEKEEISSSRKEKEEIS 489

Query: 2426 SFETSKEPEIPQSWQERTIDGEKTLIEQSERESMKLERSDESDSIEVLEHTGVMDGSHEA 2247
            S    KE EI  S +E+    E+    + E+E +   R ++ +     +    +  S + 
Sbjct: 490  SSRKEKE-EISSSRKEK----EEISSSRKEKEEISSSRKEKEEISSSRKEKEEISSSRKE 544

Query: 2246 STIKEEHSSKII----DTETVEDKKIAEDDAVHDQSTDPCRYETVDRSLVNDEKEQKSIE 2079
                +   S II     T  VE+K    +  V   S +  +   +   ++ +        
Sbjct: 545  KENTQLGLSNIIKGKLSTFDVEEKPKEREFEVKKSSEEENKNNEIPSEIITESYN----- 599

Query: 2078 LEPELEDDYYHTRAIEQGSNSKNQNXXXXXXXXXXXXEIIQDIIVEEHTANAAEEV---- 1911
               E  DD+   +  E+ S S+N                 +     E T+N   E     
Sbjct: 600  ---ETNDDFESEKPKEEVSKSENDFESEKHIDSAQKESEKEQAKQSEETSNLESEFESEK 656

Query: 1910 ----IVQENSPKDDKVSKAPEGKVKESDIVFMEASDS---VRXXXXXXXXXXXXEGPKKS 1752
                  +E    +DK+S   + K KE+D  F E        +            EG K+ 
Sbjct: 657  HKESSKEETESDNDKLSDKKQEKDKETDDDFEEEGKKDQITQSEEEKLNEIISSEGDKEK 716

Query: 1751 IDNF------------GTTEATLEEITKMETNDKP---NYSSTESSLSEEQGMVEIPEKT 1617
              +F               EAT E+ ++ E   KP   ++   E    E     +I  K 
Sbjct: 717  DFHFIEEKKPNNEIQDDFEEATEEKYSEREELMKPTEPDFQQEEKQKEEVNEEKQIDRKE 776

Query: 1616 ----ESNNNETIFATPLTERLSLQDAETEDGELVDASSLAS-----AKMIATQNQDVDDV 1464
                E    E I    +++ +   D + E  E+   S+ A      +K + ++ ++   V
Sbjct: 777  NDFLEETKEEQIHEVKVSDDIK-DDFKEEQKEIEHESNNAEESTNKSKEVVSETEEESKV 835

Query: 1463 KQKKSSNLTDNRT-----EDKFTAENSEAAAQEKSDIPVETSSIVLQSVDRDTETASVEE 1299
            + K+  N ++  T     ED++  E  +   +E  + P E  +        + +  + EE
Sbjct: 836  QTKERENPSEEETKEEPFEDEYKEETKDENTEEIKEEPFEDET------KEENKDKNKEE 889

Query: 1298 ITARKPSSVDILERNPQEPSKLVSTKEEL-------NKIGTQVMEAPLVEQTKREMNTQK 1140
                +P   +  E  P E      TKEE        NK  T+  E P  ++TK E   + 
Sbjct: 890  TKEEEPFEDETKEEEPFEDENKEETKEETKEENKDENKEETKE-EEPFEDETKEENKDEN 948

Query: 1139 EQDIKLEEDPATGIENSEQKISIPESDTEKHISEQKDGDVILERGD-NTELNXXXXXXXX 963
            +++ K E    +  E  E      E+  E    E  DG+   E  D N E N        
Sbjct: 949  KEETKEETKDKSKEETKE------ETKDETKEEEPFDGETKEENKDENKEENKDENKEET 1002

Query: 962  XXXXXSLKENQPESEESSLKDHETSDTCVNIKTDILEQEEDPIKKH----DQNLEEIKKE 795
                   +EN+ E++E    + ET +     K +  E+ +D  K+     D++ EE K+E
Sbjct: 1003 K------EENKEETKEEEPFEDETKE---ETKDETKEETKDETKEEEPFEDESKEETKEE 1053

Query: 794  MKVDENVLEV-QSTDHSNEINEPCDTTENVTIAKKNLEATDPCEELKKPTETVDHDQSQE 618
             K DEN  E  + T    +  EP +  EN    K+  +  +P E+     ET + ++ +E
Sbjct: 1054 NK-DENKEETKEETKEETKEEEPFED-ENKEETKEETKEDEPFED-----ETKEENKEEE 1106

Query: 617  VLPEIEKTEVVNDGEIIKDQDTVFAEDRTVEQSIEEEKENDTLDKAGHKVDV-------- 462
               +  K E   D    KD      E+ T  ++  +E+E++  +KA     V        
Sbjct: 1107 PFEDENKEETKEDN---KDD----YEEETKHENNVQEQEDEPTNKANPIASVDEEFEEVF 1159

Query: 461  --EDQSNDMHHVNHLMKDTXXXXXXXXXXXXXEGDNIEKQSIEEEAAKCVGVLDYKTRDK 288
              ED+  + H    L ++              +      +  EEE  +     + K  + 
Sbjct: 1160 KDEDREFEKHSQEELNREVKEEREFIPQKDETKDQESNHEDFEEEIKE-----EQKIDED 1214

Query: 287  EVKDSDFTSNEGIANATYCKEKTEPDALTCVKELNQSVNASCD--TEASIEEVLEQEEVS 114
             +K+ +    E + N  + +E  E D    +KE ++ V        E   +E  +Q+EV 
Sbjct: 1215 TIKEEEEQKTEKVQN-DFDEEIKEED----IKEKHEEVTKDKVEMNEEQNDEEKQQQEVE 1269

Query: 113  NTASEDLGE 87
            +T  ED+ E
Sbjct: 1270 STIEEDITE 1278


>ref|XP_001645325.1| hypothetical protein Kpol_1058p4 [Vanderwaltozyma polyspora DSM
            70294] gi|156115986|gb|EDO17467.1| hypothetical protein
            Kpol_1058p4 [Vanderwaltozyma polyspora DSM 70294]
          Length = 4380

 Score =  182 bits (462), Expect = 8e-43
 Identities = 338/1646 (20%), Positives = 574/1646 (34%), Gaps = 79/1646 (4%)
 Frame = -2

Query: 4769 YTPTIGEEPTKECHEKEKVIEESKF--DANKNIEEPTIEENDHSTTTILEKTIRDAHEND 4596
            Y  T  EE T+    ++   E+       N+N E  T EE   ST T  E T  +    +
Sbjct: 358  YPKTSTEESTEVLSTEQTTTEDETTGQSTNENSEPTTTEEQ--STETPSEPTTTEEESTE 415

Query: 4595 KAVEDAIIEDVVMDYPKKAITEETLKDGLEENKVIEGRNIVGADKDIDDPFIVEDDKCDV 4416
            +  E +  E+          TEET +    E +         + ++  +P   E++  + 
Sbjct: 416  ETSEPSTTEE--------ESTEETSEPSTTEEE---------STQETSEPSTTEEESTEE 458

Query: 4415 TA---TTRENSIKDGHEEDKVIDEVKIVEADNDTSEHVREEEVADNSTTTI-----MEEP 4260
            T+   TT E S ++  E     +E     ++  T+E    EE ++ STT         EP
Sbjct: 459  TSEPSTTEEESTQETSEPTTTEEESTQETSEPSTTEEESTEETSEPSTTEEESTQETSEP 518

Query: 4259 TNNDHEE----DEIGLNATEGLEVVHADKDSEVPVIEENVVPYHSTTIVGDQTTNDGHEK 4092
            T  + E      E      E  E       +E    EE   P  +     ++T+     +
Sbjct: 519  TTTEEESTEETSEPSTTEEESTEETSEPSTTEEESTEETSEPSTTEEESTEETSEPSTTE 578

Query: 4091 DKGIEKL-EIGGADQTTATIGEEPV---EDDHGETKVAETLESASAHKDIGEHIIEEDVP 3924
            ++  E+  E    ++ +     EP    E+   ET    T E  S  +       EE+  
Sbjct: 579  EESTEETSEPSTTEEESTEETSEPTTTEEESTEETSEPSTTEQESTQETSEPSTTEEEST 638

Query: 3923 DHSR--TTISEEKVIERLEIIDANKNSGVAITDNNVVLDDSTR------TTEQEPTKNGE 3768
            + +   TT  EE   E  E     + S    ++ +   ++ST       TTEQE T+   
Sbjct: 639  EETSEPTTTEEESTEETSEPSTTEEESTEETSEPSTTEEESTEETSEPSTTEQESTQETS 698

Query: 3767 EENKVIQK-LEISSADKVIGDPIIEDVPEHSTTTTGEEPVKEGHKENKVIEQIQILGLDK 3591
            E +   ++  E +S      +   E+  E STT   EE   E   E    E         
Sbjct: 699  EPSTTEEESTEETSEPSTTEEESTEETSEPSTT---EEESTEETSEPSTTE--------- 746

Query: 3590 EIGGPVVEENVAPNHSTTVIGEEAIHDGLEEDETIDGLQVDSTDKVNEEAITKEDLAQEH 3411
                   EE+       T   EE+  +  E   T    + +ST++ +E + T+E+  QE 
Sbjct: 747  -------EESTEETSEPTTTEEESTQETSEPSTT----EEESTEETSEPSTTEEESTQET 795

Query: 3410 STTTTQEKLIEDDHGENKVSTELAIGEASRDAV-----KQITKDGSITELSTVSDIKE-- 3252
            S  TT E+   +   E   + E +  E S  +       + T + S TE  +  +  E  
Sbjct: 796  SEPTTTEEQSTETPSEPTTTEEESTEETSEPSTTEEESTEETSEPSTTEEESTEETSEPS 855

Query: 3251 MTKENSQEEQMEAKKYEGEVKELDLSTKTYEAPASAQKEETMTPSDEKEQHKNQHADSAT 3072
             T+E S +E  E    E E  E      T E  ++ +  E  T  +E  Q  ++   +  
Sbjct: 856  TTEEESTQETSEPSTTEEESTEETSEPSTTEEESTQETSEPTTTEEESTQETSEPTTTEE 915

Query: 3071 DAT-----TGKTNEKGSEDLNDTSTGLNFEEADMLDGSSSLIPEVYXXXXXXXXXXXXEG 2907
            ++T        T E+ +E+ ++ ST    EE+       S   E              E 
Sbjct: 916  ESTEETSEPSTTEEESTEETSEPST--TEEESTQETSEPSTTEEESTEETSEPSTTEEES 973

Query: 2906 TEDGPNSLEGVKKASLHDAESECRELTELSEEVNRATSINDSENNTSKKEQGSIKNLEEC 2727
            TE+        ++++   +E    E     E    +T+  +S   TS+      ++ +E 
Sbjct: 974  TEETSEPSTTEQESTQETSEPSTTEEESTEETSEPSTTEEESTEETSEPTTTEEESTQET 1033

Query: 2726 IKEETIDTKLRNHLGDREIQNQEVVASVGLTSEEQNFKPVSLSEKIE--CLDAENLNKHV 2553
             +  T + +      +     +E   S   TSE    +  S  E  E    + E+  +  
Sbjct: 1034 SEPSTTEEESTEETSEPTTTEEE---STQETSEPSTTEEESTEETSEPSTTEEESTQETS 1090

Query: 2552 DDSTTTHQLQENHAKAGSDFIPENKVHEKDTYSSKKEEQNVESFE-TSKEPEIPQSWQER 2376
            + STT  +  E  ++  +    E    E    S+ +EE   E+ E T+ E E  Q   E 
Sbjct: 1091 EPSTTEEESTEETSEPST--TEEESTEETSEPSTTEEESTEETSEPTTTEEESTQETSEP 1148

Query: 2375 TIDGEKTLIEQSERESMKLERSDESDSIEVLEHTGVMDGSHEASTIKEEHSSKIIDTETV 2196
            +   E++  E SE  + + E ++E+      E     + S E ST +EE + +  +  T 
Sbjct: 1149 STTEEESTEETSEPSTTEEESTEETSEPSTTEEESTEETS-EPSTTEEESTEETSEPSTT 1207

Query: 2195 ED---KKIAEDDAVHDQSTDPCRYETVDRSLVNDEKEQKSIELEPELEDDYYHTRAIEQG 2025
            E+   ++ +E     ++ST+     +       +E  + S   E   E+    T   E+ 
Sbjct: 1208 EEESTEETSEPSTTEEESTEETSEPSTTEEESTEETSEPSTTEEESTEETSEPTTTEEES 1267

Query: 2024 SNSKNQNXXXXXXXXXXXXEIIQDIIVEEHTANAAEEVIVQENSPKDDKVSKAPE----G 1857
            +   ++             E       EE T   +E    +E S ++       E     
Sbjct: 1268 TEETSEPSTTEQESTQETSE--PSTTEEESTEETSEPSTTEEESTEETSEPTTTEEESTQ 1325

Query: 1856 KVKESDIVFMEASDSVRXXXXXXXXXXXXEGPKKSIDNFGTTE----ATLEEITKMETND 1689
            +  E      E+++                    + +   T E    +T EE +   T  
Sbjct: 1326 ETSEPSTTDEESTEETSEPTTTEEESTQETSEPSTTEEESTEETSEPSTTEEESTEATET 1385

Query: 1688 KPNYSSTESSLSEEQGMVEIPEKTESNNNETIFATPLTERLSLQDAETEDGELVDA--SS 1515
                 +TES+L+ E G  E  E TES        + L          TE  E  +A  SS
Sbjct: 1386 TETTEATESTLASESG--ESTETTESTETAEATESSLATESGESTEATETTETTEATESS 1443

Query: 1514 LASAKMIATQNQDVDDVKQKKSSNLTDNRTEDKFTAENSEAAAQEKSDIPVETSSIVLQS 1335
            LA+    +T+  +  +  +   S+L     E     E +E     +S +  E+       
Sbjct: 1444 LATESGESTEATETTETTEATESSLATESGESTEATETTETTEATESSLATESGEST--E 1501

Query: 1334 VDRDTETASVEEITARKPSSVDILERNPQEPSKLV-STKEELNKIGTQVMEAPLVEQTKR 1158
                TETA   E T    S          E ++   ST    +   T+  E+ LV  T+ 
Sbjct: 1502 ATETTETAEATESTLATESGESTEATETTETAEATESTLASESGESTEATESSLV--TES 1559

Query: 1157 EMNTQKEQDIKLEEDPATGIENSEQKISIPESDTEKHISEQKDGDVILERGDNTELNXXX 978
             +++++E          +G + +E   S  E+      +E  +  +  E G++TE     
Sbjct: 1560 GISSEEETTTLCPTCTPSGSDMTESGES-TEATESTETAEATESTLASESGESTEATE-- 1616

Query: 977  XXXXXXXXXXSLKENQPESEESSLKDHETSDTCVNIKTDILEQEEDPIKKHDQNLEEIKK 798
                             E+ ESSL       T     T+ +E  E  +        E  +
Sbjct: 1617 ------------TTETAEATESSLATESGESTEATETTETVEATESTLASESGESTEATE 1664

Query: 797  EMKVDENVLEVQSTDHSNEINEPCDTTENVTIAKKNLEATDPCE--ELKKPTETVDHDQS 624
              +  E   E      S E  E  +TTE     + +L AT+  E  E  + TETV+  +S
Sbjct: 1665 TTETAE-ATESSLATESGESTEATETTETAEATESSL-ATESGESTEATETTETVEATES 1722

Query: 623  QEVLPEIEKTEVVNDGEIIKDQDTVFAE------DRTVEQSIEEEKENDTLDKAGHKVDV 462
                   E TE     E  +  ++  A       + T      E  E+    ++G   + 
Sbjct: 1723 TLASESGESTEATETTETTEATESTLASESGESTEATETTETTEATESSLATESGESTEA 1782

Query: 461  EDQSNDMHHVNHLMKDTXXXXXXXXXXXXXEGDNIEKQSIEEEAAKC------------V 318
             + +  +      +                    I  +  EE    C             
Sbjct: 1783 TETTETVEATESTLASESGESTEATESSLVTESGISSE--EETTTLCPTCTPSGSDMTES 1840

Query: 317  GVLDYKTRDKEVKDSDFTSNEG-IANATYCKEKTEPDALTCVKELNQSVNASCDTEA--S 147
            G     T   E  +S   S  G    AT   E  E    T   E  +S  A+  TE   +
Sbjct: 1841 GESTEATESTEATESTLASESGESTEATETTETAEATESTLASESGESTEATETTETAEA 1900

Query: 146  IEEVLEQEEVSNTASEDLGEVVTGTE 69
             E  L  E   +T + +  E V  TE
Sbjct: 1901 TESSLATESGESTEATETTETVEATE 1926



 Score =  147 bits (370), Expect = 4e-32
 Identities = 350/1750 (20%), Positives = 611/1750 (34%), Gaps = 140/1750 (8%)
 Frame = -2

Query: 4898 TTTEEKSINDGREKDKITAGLAIANADKGIGEP-VIEEDVIQDQYTPTIGEEP-TKECHE 4725
            +TTEE+S  +  E            + +   EP   EE+  Q+   PT  EE  T+E  E
Sbjct: 855  STTEEESTQETSEPSTTEE-----ESTEETSEPSTTEEESTQETSEPTTTEEESTQETSE 909

Query: 4724 KEKVIEESKFDANK--NIEEPTIEENDHSTTTILEKTIRDAHENDKAVEDAIIEDVVMDY 4551
                 EES  + ++    EE + EE    +TT  E T ++  E     E++  E      
Sbjct: 910  PTTTEEESTEETSEPSTTEEESTEETSEPSTTEEEST-QETSEPSTTEEESTEETSEPST 968

Query: 4550 PKKAITEETLKDGLEENKVIEGRNIVGADKDIDDPFIVEDDKCDVTA---TTRENSIKDG 4380
             ++  TEET +    E +         + ++  +P   E++  + T+   TT E S ++ 
Sbjct: 969  TEEESTEETSEPSTTEQE---------STQETSEPSTTEEESTEETSEPSTTEEESTEET 1019

Query: 4379 HEEDKVIDEVKIVEADNDTSEHVREEEVADNSTTTIMEEPTNNDHEEDEIGLNATEGL-E 4203
             E     +E     ++  T+E    EE ++ +TT   EE T    E       +TE   E
Sbjct: 1020 SEPTTTEEESTQETSEPSTTEEESTEETSEPTTTE--EESTQETSEPSTTEEESTEETSE 1077

Query: 4202 VVHADKDSEVPVIEENVVPYHSTTIVGDQTTNDGHEKDKGIEKLEIGGADQTTATIGEEP 4023
                +++S     E +     ST    + +T    E++   E  E    ++ +     EP
Sbjct: 1078 PSTTEEESTQETSEPSTTEEESTEETSEPSTT---EEESTEETSEPSTTEEESTEETSEP 1134

Query: 4022 V---EDDHGETKVAETLESASAHKDIGEHIIEEDVPDHSR--TTISEEKVIERLEIIDAN 3858
                E+   ET    T E  S  +       EE+  + +   +T  EE   E  E     
Sbjct: 1135 TTTEEESTQETSEPSTTEEESTEETSEPSTTEEESTEETSEPSTTEEESTEETSEPSTTE 1194

Query: 3857 KNSGVAITDNNVVLDDSTR------TTEQEPTKNGEEENKVIQKLEISSADKVIGDPIIE 3696
            + S    ++ +   ++ST       TTE+E T+   E +   ++    +++    +   E
Sbjct: 1195 EESTEETSEPSTTEEESTEETSEPSTTEEESTEETSEPSTTEEESTEETSEPSTTEE--E 1252

Query: 3695 DVPEHSTTTTGEEPVKEGHKENKVIEQIQILGLDKEIGGPVV--EENVAPNHSTTVIGEE 3522
               E S  TT EE   E   E    EQ       +E   P    EE+       +   EE
Sbjct: 1253 STEETSEPTTTEEESTEETSEPSTTEQEST----QETSEPSTTEEESTEETSEPSTTEEE 1308

Query: 3521 AIHDG-----LEEDETIDGLQVDSTDKVNEEAITKEDLAQEHSTTTTQEKLIEDDHGENK 3357
            +  +       EE+ T +  +  +TD+ + E  ++    +E ST  T E    ++    +
Sbjct: 1309 STEETSEPTTTEEESTQETSEPSTTDEESTEETSEPTTTEEESTQETSEPSTTEEESTEE 1368

Query: 3356 VSTELAIGEASRDAVKQITKDGSITELSTVSDIKEMTKENSQEEQMEAKK-----YEGEV 3192
             S      E S +A  + T+    TE +  S+  E T+     E  EA +       GE 
Sbjct: 1369 TSEPSTTEEESTEAT-ETTETTEATESTLASESGESTETTESTETAEATESSLATESGES 1427

Query: 3191 KELDLSTKTYEAPASA---------QKEETMTPSDEKEQHKNQHADSATDATTGKTNEKG 3039
             E   +T+T EA  S+         +  ET   ++  E      +  +T+AT      + 
Sbjct: 1428 TEATETTETTEATESSLATESGESTEATETTETTEATESSLATESGESTEATETTETTEA 1487

Query: 3038 SEDLNDTSTGLNFEEADMLDGS----SSLIPEVYXXXXXXXXXXXXEGTE-----DGPNS 2886
            +E    T +G + E  +  + +    S+L  E              E TE     +   S
Sbjct: 1488 TESSLATESGESTEATETTETAEATESTLATESGESTEATETTETAEATESTLASESGES 1547

Query: 2885 LEGVKKASLHDAESECRE---------------LTELSE--EVNRATSINDSENNTSKKE 2757
             E  + + + ++     E               +TE  E  E   +T   ++  +T   E
Sbjct: 1548 TEATESSLVTESGISSEEETTTLCPTCTPSGSDMTESGESTEATESTETAEATESTLASE 1607

Query: 2756 QG-SIKNLEECIKEETIDTKLRNHLGD--REIQNQEVVASVGLTSEEQNFKPVSLSEKIE 2586
             G S +  E     E  ++ L    G+     +  E V +   T   ++ +    +E  E
Sbjct: 1608 SGESTEATETTETAEATESSLATESGESTEATETTETVEATESTLASESGESTEATETTE 1667

Query: 2585 CLDA--ENLNKHVDDSTTTHQLQENHAKAGSDFIPENKVHEKDTYSSKKEE--------- 2439
              +A   +L     +ST   +  E      S    E+    + T +++  E         
Sbjct: 1668 TAEATESSLATESGESTEATETTETAEATESSLATESGESTEATETTETVEATESTLASE 1727

Query: 2438 --QNVESFETSKEPEIPQSWQERTIDGEKTLIEQSERESMKLERS---DESDSIEVLEHT 2274
              ++ E+ ET++  E  +S    +  GE T   ++   +   E S   +  +S E  E T
Sbjct: 1728 SGESTEATETTETTEATES-TLASESGESTEATETTETTEATESSLATESGESTEATETT 1786

Query: 2273 GVMDGSHEASTIKEEHSSKIIDTETVEDKKIAEDDAVHDQSTDPCRYETVDRSLVNDEKE 2094
              ++ +      +   S++  ++  V +  I+ +    +++T  C   T   S + +  E
Sbjct: 1787 ETVEATESTLASESGESTEATESSLVTESGISSE----EETTTLCPTCTPSGSDMTESGE 1842

Query: 2093 QKSIELEPELEDDYYHTRAIEQGSNSK----NQNXXXXXXXXXXXXEIIQDIIVEEHTAN 1926
                    E  +    T A E G +++     +                 +      TA 
Sbjct: 1843 STEATESTEATES---TLASESGESTEATETTETAEATESTLASESGESTEATETTETAE 1899

Query: 1925 AAEEVIVQENSPKDDKVSKAPEGKVKESDIV-----FMEASDSVRXXXXXXXXXXXXEGP 1761
            A E  +  E+    +        +  ES +        EA+++               G 
Sbjct: 1900 ATESSLATESGESTEATETTETVEATESTLASESGESTEATETTETAEATESSLATESG- 1958

Query: 1760 KKSIDNFGTTEATLEEITKMETNDKPNYSSTESSLSEEQGMVEIPEKTESNNNETIFATP 1581
             +S +   TTE      + + +    +  +TESSL  E G+    E T      T   + 
Sbjct: 1959 -ESTEATETTETVEATESTLASESGESTEATESSLVTESGISSEEETTTLCPTCTPSGSD 2017

Query: 1580 LTERLSLQDAETEDGELVDA--SSLASAKMIATQNQDVDDVKQKKSSNLTDNRTEDKFTA 1407
            +TE     +A TE  E V+A  S+LAS    +T+  +  +  +   S L     E     
Sbjct: 2018 MTESGESTEA-TESTETVEATESTLASESGESTEATETTETAEATESTLASESGESTEAT 2076

Query: 1406 ENSEAAAQEKSDIPVETSSIVLQSVDRDTETASVEEITARKPS-----SVDILERNPQEP 1242
            E +E     +S +  E+           TETA   E T    S     + +  E      
Sbjct: 2077 ETTETTEASESSLATESGEST--EATETTETAEATESTLATESGESTEATETTETVEATE 2134

Query: 1241 SKLVSTKEELNKIGTQVMEAPLVEQTKREMNTQKEQDIKLEEDPATGIENSEQKISIPES 1062
            S L S   E  +  T+  E    E T+  + T+  +  +  E        +E  IS  E 
Sbjct: 2135 STLASESGESTE-ATETTET--AEATESSLATESGESTEATESSLV----TESGISSEEE 2187

Query: 1061 DTEKHISEQKDGDVILERGDNTELNXXXXXXXXXXXXXSLKENQPESEESSLKDHETSDT 882
             T    +    G  + E G++TE                      E+ ES+L       T
Sbjct: 2188 TTTLCPTCTPSGSDMTESGESTEATE--------------STETAEATESTLASESGEST 2233

Query: 881  CVNIKTDILEQEEDPIKKHDQNLEEIKKEMKVDENVLEVQSTDHSNEINEPCDTTENV-- 708
                 T+  E  E  +        E  +  +  E V E      S E  E  +TTE    
Sbjct: 2234 EATETTETTEATESSLASESGKSTEATESTEATE-VTESSLASESGESTEATETTETAEA 2292

Query: 707  ---TIAKKNLEATDPCE---------------------------ELKKPTETVDHDQSQE 618
               T+A ++ E+T+  E                           ++ + TE+++   + E
Sbjct: 2293 TESTLASESGESTEATESSLVTESGISSEGETTTLCPTCTPSGSDMTEATESIESTPATE 2352

Query: 617  VLPEIEKTEVVNDGEIIKDQDTVFAEDRTVEQSIEEEKENDTLDKAGHKVDVEDQS--ND 444
                 E T     GE  +  +T    + T      E  E+    +     +  + S   +
Sbjct: 2353 ATEATESTLASESGESTEATETTETAEATESTLASESGESTEATETTETAEATESSLATE 2412

Query: 443  MHHVNHLMKDTXXXXXXXXXXXXXEGDNIEKQSIEE--EAAKCVGVLDYKTRDKEVKDSD 270
                    + T              G++ E     E  EA +        T   EV +S 
Sbjct: 2413 SGESTEATETTETTEATESSLASESGESTEATESTETTEATE-------STEATEVTESS 2465

Query: 269  FTSNEG-IANATYCKEKTEPDALTCVKELNQSVNASCDTEAS-IEEVLEQEEVSNTA-SE 99
              S  G    AT   E TE    +   E  +S  A+  TE +   E  E  EV+ ++ + 
Sbjct: 2466 LASESGESTEATETTEATEVTESSLASESGESTEATETTETTEATESTEATEVTESSLAS 2525

Query: 98   DLGEVVTGTE 69
            + GE    TE
Sbjct: 2526 ESGESTEATE 2535



 Score =  124 bits (311), Expect = 3e-25
 Identities = 274/1410 (19%), Positives = 486/1410 (34%), Gaps = 108/1410 (7%)
 Frame = -2

Query: 4898 TTTEEKSINDGREKDKITAGLAIANADKGIGEPVI-EEDVIQDQYTPTIGEEPTKECHEK 4722
            TTTEE+S  +  E            + +   EP   EE+  Q+   P+  EE + E   +
Sbjct: 1317 TTTEEESTQETSEPSTTDE-----ESTEETSEPTTTEEESTQETSEPSTTEEESTEETSE 1371

Query: 4721 EKVIEESKFDANKNIE-----EPTI-EENDHSTTTILEKTIRDAHENDKAVEDAIIEDVV 4560
                EE   +A +  E     E T+  E+  ST T       +A E+  A E     +  
Sbjct: 1372 PSTTEEESTEATETTETTEATESTLASESGESTETTESTETAEATESSLATESGESTEAT 1431

Query: 4559 MDYPKKAITEETLKDGLEENKVIEGRNIVGADKDIDDPFIVED-------DKCDVTATTR 4401
                    TE +L    E  +  E        +  +     E        +  + T  T 
Sbjct: 1432 ETTETTEATESSL--ATESGESTEATETTETTEATESSLATESGESTEATETTETTEATE 1489

Query: 4400 ENSIKDGHEEDKVIDEVKIVEADNDT--------SEHVREEEVADNSTTTIMEEPTNNDH 4245
             +   +  E  +  +  +  EA   T        +E     E A+ + +T+  E   +  
Sbjct: 1490 SSLATESGESTEATETTETAEATESTLATESGESTEATETTETAEATESTLASESGESTE 1549

Query: 4244 -------------EEDEI----------GLNATEGLEVVHADKDSEVPVIEENVVPYHS- 4137
                          E+E           G + TE  E   A + +E     E+ +   S 
Sbjct: 1550 ATESSLVTESGISSEEETTTLCPTCTPSGSDMTESGESTEATESTETAEATESTLASESG 1609

Query: 4136 --TTIVGDQTTNDGHEKDKGIEKLEIGGADQTTATIG--EEPVEDDHGE-TKVAETLESA 3972
              T       T +  E     E  E   A +TT T+   E  +  + GE T+  ET E+A
Sbjct: 1610 ESTEATETTETAEATESSLATESGESTEATETTETVEATESTLASESGESTEATETTETA 1669

Query: 3971 SAHK-----DIGEHIIEEDVPDHSRTTISE--------EKVIERLEIIDANKNSGVAITD 3831
             A +     + GE     +  + +  T S          +  E  E ++A +++  + + 
Sbjct: 1670 EATESSLATESGESTEATETTETAEATESSLATESGESTEATETTETVEATESTLASESG 1729

Query: 3830 NNVVLDDSTRTTEQEPTKNGEEENKVIQKLEISSADKVIGDPIIEDVPEHSTTTTGEEPV 3651
             +    ++T TTE   +    E  +  +  E +   +     +  +  E +  T   E V
Sbjct: 1730 ESTEATETTETTEATESTLASESGESTEATETTETTEATESSLATESGESTEATETTETV 1789

Query: 3650 KEGHKENKVIEQIQILGLDKEIGGPVVEENVAPNHSTTVIGEEAIHDGLEEDETIDGLQV 3471
             E  +     E  +    +      V E  ++    TT +       G +  E+ +  + 
Sbjct: 1790 -EATESTLASESGE--STEATESSLVTESGISSEEETTTLCPTCTPSGSDMTESGESTEA 1846

Query: 3470 DSTDKVNEEAITKEDLAQEHSTTTTQ-----EKLIEDDHGENKVSTELA-IGEASRDAVK 3309
              + +  E  +  E      +T TT+     E  +  + GE+  +TE     EA+  ++ 
Sbjct: 1847 TESTEATESTLASESGESTEATETTETAEATESTLASESGESTEATETTETAEATESSLA 1906

Query: 3308 QITKDGSITELSTVSDIKEMTKENSQEEQMEAKKYEGEVKELDLSTKTYEAPASAQKEET 3129
              T+ G  TE +  ++  E T+     E        GE  E   +T+T EA  S+   E+
Sbjct: 1907 --TESGESTEATETTETVEATESTLASES-------GESTEATETTETAEATESSLATES 1957

Query: 3128 MTPSDEKEQHKNQHADSATDATTGKTNEKGSEDLNDTSTGLNFEEADMLDGSSSLIPEVY 2949
               ++  E  +   A  +T A+    + + +E    T +G++ EE      +++L P   
Sbjct: 1958 GESTEATETTETVEATESTLASESGESTEATESSLVTESGISSEEE-----TTTLCPTCT 2012

Query: 2948 XXXXXXXXXXXXEGTEDGPNSLEGVKKASLHDAESECRELTELSEEVNRATSINDSENNT 2769
                            +   ++E  + ++L     E  E TE +E      S   SE+  
Sbjct: 2013 PSGSDMTESGESTEATESTETVEATE-STLASESGESTEATETTETAEATESTLASESGE 2071

Query: 2768 SKKEQGSIKNLEECIKEETIDTKLRNHLGDREI-QNQEVVASVGLTSEEQNFKPVSLSEK 2592
            S +   + +  E    E ++ T+        E  +  E   S   T   ++ +    +E 
Sbjct: 2072 STEATETTETTEA--SESSLATESGESTEATETTETAEATESTLATESGESTEATETTET 2129

Query: 2591 IECLDAENLNKHVDDSTTTHQLQENHAKAGSDFIPENKVHEKDTYSSKKEEQNVESFE-- 2418
            +E  ++  L     +ST   +  E      S    E+    + T SS   E  + S E  
Sbjct: 2130 VEATES-TLASESGESTEATETTETAEATESSLATESGESTEATESSLVTESGISSEEET 2188

Query: 2417 TSKEPEIPQSWQERTIDGEKTLIEQSERESMKLER---SDESDSIEVLEHTGVMDGSHEA 2247
            T+  P    S  + T  GE T   +S   +   E    S+  +S E  E T   + +  +
Sbjct: 2189 TTLCPTCTPSGSDMTESGESTEATESTETAEATESTLASESGESTEATETTETTEATESS 2248

Query: 2246 ----------------------STIKEEHSSKIIDTETVEDKKIAEDDAVHD--QSTDPC 2139
                                  S++  E       TET E  +  E     +  +ST+  
Sbjct: 2249 LASESGKSTEATESTEATEVTESSLASESGESTEATETTETAEATESTLASESGESTEAT 2308

Query: 2138 RYETVDRSLVNDEKEQKSI--ELEPELEDDYYHTRAIEQGSNSKNQNXXXXXXXXXXXXE 1965
                V  S ++ E E  ++     P   D    T +IE  S    +              
Sbjct: 2309 ESSLVTESGISSEGETTTLCPTCTPSGSDMTEATESIE--STPATEATEATESTLASESG 2366

Query: 1964 IIQDIIVEEHTANAAEEVIVQENSPKDDKVSKAPEGKVKESDIVFMEASDSVRXXXXXXX 1785
               +      TA A E  +  E+    +        +  ES +   E+ +S         
Sbjct: 2367 ESTEATETTETAEATESTLASESGESTEATETTETAEATESSLA-TESGESTEATETTET 2425

Query: 1784 XXXXXEGPKKSIDNFGTTEATLEEITKMETNDKPNYSSTESSLSEEQGMVEIPEKTESNN 1605
                      + ++  +TEAT    T   T        TESSL+ E G     E TE+  
Sbjct: 2426 TEATESS--LASESGESTEATESTETTEATESTEATEVTESSLASESG-----ESTEA-- 2476

Query: 1604 NETIFATPLTERLSLQDAETEDGELVDASSLASAKMIATQNQDVDDVKQKKSSNLTDNRT 1425
             ET  AT +TE        +E GE  +A+        AT++ +  +V +   ++ +   T
Sbjct: 2477 TETTEATEVTE----SSLASESGESTEATETTETTE-ATESTEATEVTESSLASESGEST 2531

Query: 1424 EDKFTAENSEAAAQEKSDIPVETSSIVLQSVDRDTETASVEEITAR----KPSSVDILER 1257
            E   T E +EA     +    E++     S+  ++  +S EE T       PS  D+ E 
Sbjct: 2532 EATETTETAEATESSLATESGESTEATESSLVTESGISSEEETTTLCPTCTPSGSDMTES 2591

Query: 1256 NPQ-EPSKLVSTKEEL-NKIGTQVMEAPLVEQTKREMNTQKEQDIKLEEDPATGIENSEQ 1083
                E ++   T E   + + ++  E+    +T  E     E  +  E   +T    S +
Sbjct: 2592 GESTEATESTETAEATESTLASESGESTEATET-TETTEATESSLASESGKSTEATESTE 2650

Query: 1082 KISIPESDTEKHISEQKDGDVILERGDNTE 993
               + ES       E  +     E  + TE
Sbjct: 2651 ATEVTESSLASESGESTEATETTETAEATE 2680